David J. Cosman

David J. Cosman's AcademicInfluence.com Rankings

David J. Cosman

Biology

#11782

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#15205

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Immunology

#770

World Rank

#793

Historical Rank

Molecular Biology

#1854

World Rank

#1883

Historical Rank

Biochemistry

#1966

World Rank

#2107

Historical Rank

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Biology

David J. Cosman's Degrees

PhD Biomedical Sciences University of California, San Francisco
Masters Biochemistry Stanford University
Bachelors Biology University of California, Berkeley

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David J. Cosman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function (1997) (2310)
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs (1985) (1521)
RANK is essential for osteoclast and lymph node development. (1999) (1451)
ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (2001) (1313)
Molecular and biological characterization of a murine ligand for CD40 (1992) (1081)
Utilization of the beta and gamma chains of the IL‐2 receptor by the novel cytokine IL‐15. (1994) (990)
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. (1990) (977)
Identification of a ligand for the c-kit proto-oncogene (1990) (926)
Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms (1990) (844)
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. (1988) (838)
Stimulation of B-cell progenitors by cloned murine interleukin-7 (1988) (837)
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. (1997) (725)
c-Mpl ligand is a humoral regulator of megakaryocytopoiesis (1994) (682)
A novel IL‐1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (1991) (667)
Identification and cloning of a novel IL‐15 binding protein that is structurally related to the alpha chain of the IL‐2 receptor. (1995) (640)
Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles (1990) (607)
The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms (1989) (586)
Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130. (1991) (560)
Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily (1990) (554)
Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. (2002) (547)
A new cytokine receptor superfamily. (1990) (443)
Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. (1988) (369)
A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (1997) (360)
Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes (*) (1995) (348)
The Involvement of Multiple Tumor Necrosis Factor Receptor (TNFR)-associated Factors in the Signaling Mechanisms of Receptor Activator of NF-κB, a Member of the TNFR Superfamily* (1998) (339)
Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer. (2004) (331)
IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression. (1999) (319)
Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity (2003) (317)
HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. (2005) (313)
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains. (1991) (312)
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. (1987) (310)
The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. (1995) (308)
Dual Oncostatin M (OSM) Receptors (1996) (292)
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor (1993) (282)
UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells (2002) (279)
Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. (1989) (279)
The hematopoietin receptor superfamily. (1993) (276)
A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor. (1995) (268)
A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function* (2002) (252)
Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. (1989) (238)
IL‐15, a novel T cell growth factor that shares activities and receptor components with IL‐2 (1995) (233)
Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells (1989) (227)
ULBP4 is a novel ligand for human NKG2D. (2003) (226)
Cloning, sequence and expression of human interleukin-2 receptor (1984) (224)
NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection1 (2007) (219)
Activated, But Not Resting, T Cells Can Be Recognized and Killed by Syngeneic NK Cells 1 (2003) (219)
The MHC class I binding proteins LIR‐1 and LIR‐2 inhibit Fc receptor‐mediated signaling in monocytes (1998) (210)
Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. (2006) (209)
Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains (1990) (208)
Effects of Human Cytomegalovirus Infection on Ligands for the Activating NKG2D Receptor of NK Cells: Up-Regulation of UL16-Binding Protein (ULBP)1 and ULBP2 Is Counteracted by the Viral UL16 Protein1 (2003) (203)
Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells. (1991) (200)
Role of NK Cell-Activating Receptors and Their Ligands in the Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium1 (2005) (196)
Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. (2005) (192)
Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor (1991) (184)
Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. (2007) (183)
ULBP1, 2, 3: novel MHC class I‐related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells (2001) (177)
NK Cells Lyse T Regulatory Cells That Expand in Response to an Intracellular Pathogen1 (2008) (174)
The CD85/LIR-1/ILT2 Inhibitory Receptor Is Expressed by All Human T Lymphocytes and Down-Regulates Their Functions1 (2000) (160)
Murine thymocytes proliferate in direct response to interleukin-7. (1989) (159)
Soluble forms of CD40 inhibit biologic responses of human B cells. (1992) (156)
The UL16‐binding proteins, a novel family of MHC class I‐related ligands for NKG2D, activate natural killer cell functions (2001) (156)
Control of messenger RNA stability. (1987) (156)
Intracellular Retention of the MHC Class I-Related Chain B Ligand of NKG2D by the Human Cytomegalovirus UL16 Glycoprotein1 (2003) (150)
NKG2D ligands are expressed on stressed human airway epithelial cells. (2006) (138)
A family of ligands for the TNF receptor superfamily (1994) (138)
The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1 + NK cell clones. (1999) (136)
LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells. (2000) (133)
Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. (1993) (128)
Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. (1994) (127)
Secretion of a transplantation-related antigen (1983) (121)
Cell Surface Organization of Stress-inducible Proteins ULBP and MICA That Stimulate Human NK Cells and T Cells via NKG2D (2004) (121)
Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene. (1988) (118)
Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex. (1992) (118)
Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression. (2006) (115)
Cloning, sequence, and expression of bovine interleukin 2. (1986) (111)
New nomenclature for MHC receptors (2001) (105)
Cloning, sequence, and expression of bovine interferon-gamma. (1986) (104)
ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15. (2006) (103)
Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells. (1991) (99)
Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7 (2003) (95)
Cloning, sequence and expression of bovine interleukin 1α and interleukin 1β complementary DNAs (1988) (90)
Retention of ligand binding activity by the extracellular domain of the IL-1 receptor. (1989) (89)
Tissue-specific expression of an unusual H-2 (class I)-related gene. (1982) (84)
Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1 alpha and 1 beta. (1987) (82)
Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. (1991) (81)
Expression, purification and characterization of recombinant murine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast. (1987) (79)
Induction of an interleukin-1 receptor (IL-1R) on monocytic cells. Evidence that the receptor is not encoded by a T cell-type IL-1R mRNA. (1990) (76)
LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients (2003) (76)
Human cytomegalovirus, MHC class I and inhibitory signalling receptors: more questions than answers (1999) (72)
Expression and purification of native human granulocyte-macrophage colony-stimulating factor from an Escherichia coli secretion vector. (1987) (70)
Interleukin‐15 up‐regulates interleukin‐2 receptor α chain but down‐regulates its own high‐affinity binding sites on human T and B cells (1996) (64)
Reconstitution of a functional interleukin (IL)‐7 receptor demonstrates that the IL‐2 receptor γ chain is required for IL‐7 signal transduction (1995) (60)
The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7. (1991) (60)
Characterization of the human and murine IL-7 genes. (1990) (59)
Further evidence for a common mechanism for shedding of cell surface proteins (1997) (58)
Characterization of a temperature-sensitive, DNA-positive, nontransforming mutant of simian virus 40. (1981) (56)
Bovine GM-CSF: molecular cloning and biological activity of the recombinant protein. (1988) (56)
Three classes of mouse H–2 messenger RNA distinguished by analysis of cDNA clones (1982) (51)
The Human Cytomegalovirus Protein UL16 Mediates Increased Resistance to Natural Killer Cell Cytotoxicity through Resistance to Cytolytic Proteins (2003) (49)
Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR‐1/ILT2/CD85j (2006) (48)
Purification and Characterization of Human Interleukin–1 Expressed in Escherichia coli (1986) (48)
The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. (2002) (43)
NKG2D splice variants: a reexamination of adaptor molecule associations (2006) (42)
Stably transmitted triple-promoter retroviral vectors and their use in transformation of primary mammalian cells (1988) (40)
Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: interleukin-15 binds to the B cells but is not internalized efficiently. (1995) (39)
Human rhinovirus 3C protease: cloning and expression of an active form in Escherichia coli. (1988) (37)
Self-reported nonmusculoskeletal responses to chiropractic intervention: a multination survey. (2005) (37)
Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiency. (1999) (37)
Nature and specificity of lymphokine independence induced by a selectable retroviral vector expressing v-src (1987) (36)
The interleukin-4 receptor: structure, function, and signal transduction. (1992) (36)
Molecular characterization of the interleukin-1 receptor (IL-1R) on monocytes and polymorphonuclear cells. (1992) (36)
The leukocyte immunoglobulin‐like receptors (LIRs): a new family of immune regulators (1999) (34)
Colony-stimulating factors in vivo and in vitro. (1988) (33)
Production of recombinant human colony stimulating factors in yeast. (1988) (32)
The Action of Interleukin-2 Receptor Subunits Defines a New Type of Signaling Mechanism for Hematopoietin Receptors in Hepatic Cells and Fibroblasts (*) (1995) (32)
Allelic and interlocus comparison of the PERB11 multigene family in the MHC (1997) (32)
Phosphorylation of the human interleukin-2 receptor and a synthetic peptide identical to its C-terminal, cytoplasmic domain. (1986) (31)
Expression of interleukin-15 and its receptor by human fetal retinal pigment epithelial cells. (1996) (31)
Experimental and theoretical studies of the three‐dimensional structure of human interleukin‐4 (1991) (29)
Expression of the NKG2D ligand UL16 binding protein‐1 (ULBP‐1) on dendritic cells (2006) (28)
T-cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro (1990) (27)
NKG2D-Dependent IL-17 Production by Human T Cells in Response to an Intracellular Pathogen1 (2009) (25)
HLA class I , NKG 2 D , and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells (2004) (24)
Interleukin 15. (1997) (24)
T-cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro. (1990) (24)
Improved survival and leukocyte reconstitution without detrimental effects on engraftment in murine recipients of human recombinant granulocyte colony-stimulating factor after transplantation of T-cell-depleted histoincompatible bone marrow. (1989) (23)
Regulation of antibody production in vitro by granulocyte-macrophage colony stimulating factor. (1986) (20)
Human macrophage colony stimulating factor (M-CSF): alternate RNA splicing generates three different proteins that are expressed on the cell surface and secreted. (1988) (19)
The R27080 glycoprotein is abundantly secreted from human cytomegalovirus-infected fibroblasts. (1999) (18)
Interleukin 15 and its receptor. (1995) (18)
Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1. (2007) (17)
Membrane bound forms of human macrophage colony stimulating factor (M-CSF, CSF-1). (1990) (17)
Lymphokines: from conjecture to the clinic. (1986) (17)
The Interleukin- 1 Receptor Binds the Human Interleukin- la! Precursor but Not the Interleukin- 1@ Precursor* (2001) (16)
A role for the MHC class I‐like Mill molecules in nutrient metabolism and wound healing (2008) (16)
Interactions of LIRs, a family of immunoreceptors expressed in myeloid and lymphoid cells, with viral and cellular MHC class I antigens. (1999) (15)
Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family (1996) (15)
Survival versus neglect: redefining thymocyte subsets based on expression of NKG2D ligand(s) and MHC class I (2005) (14)
Major Histocompatibility Complex Class I-related Chain A and UL 16-Binding Protein Expression on Tumor Cell Lines of Different Histotypes : Analysis of Tumor Susceptibility to NKG 2 D-dependent Natural Killer Cell Cytotoxicity 1 (2002) (12)
The oncostatin-M specific receptor: Cloning of a novel subunit related to the LIF receptor (1994) (11)
A novel mutant γc chain from a patient with typical phenotype of X‐linked severe combined immunodeficiency (SCID) has partial signalling function for mediating IL‐2 and IL‐4 receptor action (1999) (10)
Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG 2 D and inhibits natural killer cell-mediated cytotoxicity (2006) (10)
Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAs. (1988) (9)
Ligands for natural killer cell activating receptors are expressed upon maturation of normal myelomonocytic cells but are low in acute myeloid leukemias (2005) (8)
A novel T cell factor IL-15, shares both the beta and gamma subunits of the IL-2 receptor (1994) (8)
NKG 2 D ligands are expressed on stressed human airway epithelial cells (2006) (7)
Identification of regions in interleukin-1 alpha important for activity. (1993) (7)
High level stable expression of human interleukin-2 receptors in mouse cells generates only low affinity interleukin-2 binding sites. (1986) (7)
Molecular Characterization of Colony‐ Stimulating Factors and Their Receptors: Human Interleukin‐3 (1989) (5)
Mapping of additional temperature-sensitive mutations (1600 series) on the genome of simian virus 40 by marker rescue. (1981) (4)
Human Cytomegalovirus UL16 Glycoprotein I-Related Chain B Ligand of NKG2D by the Intracellular Retention of the MHC Class (2003) (3)
Molecular structure of the interleukin 1 receptor (1988) (3)
NK Cells Lyse T Regulatory Cells in Human Infection with An Intracellular Pathogen (B167) (2007) (2)
Molecular Modification of Lymphokines by in Vitro Mutagenesis (1987) (1)
The receptors for oncostatin M (1995) (0)
BacteriumPhagocytes Infected with an Intracellular Their Ligands in the Lysis of Mononuclear Role of NK Cell-Activating Receptors and (2005) (0)
Expression cloning of cytokine and cytokine receptors by sreening pools of cDNA clones (1990) (0)
Purified human interleukin-1, its preparation and use in pharmaceutical compositions (1985) (0)
Is Counteracted by the Viral UL 16 Protein UL 16-Binding Protein ( ULBP ) 1 and ULBP 2 Receptor of NK Cells : Up-Regulation of on Ligands for the Activating NKG 2 D Effects of Human Cytomegalovirus Infection (2003) (0)
Purified interleukin-1 and interleukin-1 encoding DNA and the production thereof, vectors containing such DNA, and their production and use for transforming hosts that allow for the expression of interleukin-1 (1985) (0)
United States Patent 19 Sims et al . 54 ) DNA ENCODING TYPE II INTERLEUKIN-1 RECEPTORS 75 ) Inventors : (2017) (0)
to Cytolytic Proteins Killer Cell Cytotoxicity through Resistance Mediates Increased Resistance to Natural The Human Cytomegalovirus Protein UL16 (2014) (0)
Use of monoclonal and polyclonal antibodies to localize interleukin 1 in monokine-producing cells (1988) (0)
Is Counteracted by the Viral UL16 Protein UL16-Binding Protein (ULBP)1 and ULBP2 Receptor of NK Cells: Up-Regulation of on Ligands for the Activating NKG2D Effects of Human Cytomegalovirus Infection (2003) (0)
The Tumor-Necrosis-Factor-Related Superfamily of Ligands and Receptors (1996) (0)
Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins la and 1 ( 8 ( in vitro expression / in vitro mutagenesis / receptor assay ) (0)
Oncostatin m receptor (1995) (0)
Fusion protein consisting of GM-CSF and IL-3. (1990) (0)
Interaction of human cytomegalovirus glycoproteins with immunoreceptors (2001) (0)
IDENTIFICATION OF A NOVEL, H-2-LIKE GENE BY ANALYSIS OF cDNA CLONES (1982) (0)
Soluble Cytokine Receptors as Immunomodulators (1992) (0)
Purified interleukin-1, and DNA encoding for interleukin-1, as well as their preparation, vectors containing such DNA and to their preparation and use in the transformation of the hosts of the possible optimization of the expression of interleukin-1 (1993) (0)
USOO 5767 O 65 A 11 Patent Number : 5 , 767 , 065 45 Date of Patent : Jun . 16 , 1998 (2017) (0)
Primary NK Cells Activate Multiple Signaling Pathways in I-Related Proteins , Bind to NKG 2 D and UL 16-Binding Proteins , Novel MHC Class (2001) (0)
Intracellular Pathogen Human T Cells in Response to an NKG 2 D-Dependent IL-17 Production (2009) (0)
The type II interleukin-1 receptors (1991) (0)
Faculty Opinions recommendation of Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. (2005) (0)
ExpressionCloningofa Human Granulocyte Colony-stimulating FactorReceptor:A Structural MosaicofHematopoietinReceptor,Immunoglobulin, and FibronectinDomains (1990) (0)
Influenza Infection Activation in the Human Response to Dendritic Cells Is Necessary for NK Cell NKp46 and NKG2D Recognition of Infected (2007) (0)
Cloning of the gene for human granulocyte-macrophage colony stimulation factor (1985) (0)
NKG 2 D-dependent Natural Killer Cell Cytotoxicity Different Histotypes : Analysis of Tumor Susceptibility to UL 16-Binding Protein Expression on Tumor Cell Lines of Major Histocompatibility Complex Class I-related Chain A and Updated (2002) (0)
Interlocus sequence analysis of the PERB11 gene family: implication for rapid diversification to different functions (1997) (0)
Human interleukin-3 and granulocyte-macrophage colony stimulating factor: site-specific mutagenesis and expression in yeast. (1988) (0)
leukemias maturation of normal myelomonocytic cells but are low in acute myeloid Ligands for natural killer cell activating receptors are expressed upon (2013) (0)
Faculty Opinions recommendation of A secreted high-affinity inhibitor of human TNF from Tanapox virus. (2003) (0)
Tissue-specific expression of an unusual H-2 ( class I )-related gene ( transplantation antigen / graft rejection / tolerance ) (0)
DNA sequences encoding the interleukin-4 receptors, RNA complementary to the recombinant expression vector comprising these DNA sequences, host cell transfected with this vector, method of producing. (1991) (0)
Activation of tumorzerstoerenden activity of macrophages by the granulocyte-macrophage colony stimulating factor. (1986) (0)
For human interleukin-1 alpha-encoding DNA and its corresponding aminosaeurenkette, vectors and hosts containing such DNA and to their preparation. (1985) (0)

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David J. Cosman's AcademicInfluence.com Rankings