David E. Cane
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American biochemist
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Why Is David E. Cane Influential?
(Suggest an Edit or Addition)According to Wikipedia, David E. Cane is an American biological chemist. He is Vernon K. Krieble Professor of Chemistry Emeritus and professor of molecular biology, cell biology, and biochemistry emeritus at Brown University in Providence, Rhode Island. He is recognized for his work on the biosynthesis of natural products, particularly terpenoids and polyketides. He was elected as a Fellow of the American Association for the Advancement of Science in 2003 and as a Fellow of the American Academy of Arts and Sciences in 2013.
David E. Cane's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli (2001) (642)
- Harnessing the biosynthetic code: combinations, permutations, and mutations. (1998) (558)
- Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism (2010) (433)
- Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology. (1997) (381)
- Enzymic formation of sesquiterpenes (1990) (376)
- Terpene synthases are widely distributed in bacteria (2014) (352)
- Tolerance and specificity of polyketide synthases. (1999) (304)
- Dissecting and exploiting intermodular communication in polyketide synthases. (1999) (298)
- The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. (1999) (278)
- Structure and mechanism of the 6-deoxyerythronolide B synthase. (2007) (246)
- The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase (2006) (236)
- Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. (1997) (226)
- Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. (2007) (208)
- Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. (2013) (184)
- Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel (2001) (179)
- Unified stereochemical model of polyether antibiotic structure and biogenesis (1983) (163)
- Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea. (2008) (159)
- Exploration and mining of the bacterial terpenome. (2012) (156)
- Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti * (2000) (148)
- Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)* (2008) (146)
- Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase (1995) (146)
- Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. (2007) (142)
- Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis. (2002) (141)
- Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis (2003) (134)
- X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. (2007) (133)
- Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319. (1994) (133)
- Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. (2006) (130)
- Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. (1999) (129)
- Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin. (1987) (124)
- Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. (2010) (123)
- Isoprenoid biosynthesis. Stereochemistry of the cyclization of allylic pyrophosphates (1985) (120)
- Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. (2001) (116)
- Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. (2002) (116)
- Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor. (2008) (116)
- Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. (2006) (115)
- 2.06 – Sesquiterpene Biosynthesis: Cyclization Mechanisms (1999) (115)
- Isolation and characterization of the gene associated with geosmin production in cyanobacteria. (2008) (108)
- Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules. (2001) (107)
- Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. (2002) (105)
- Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems (2014) (104)
- Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis (2001) (99)
- Structure and mechanism of assembly line polyketide synthases. (2016) (97)
- A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. (2006) (96)
- Enzymatic Formation of Sesquiterpenes (1991) (95)
- Biosynthesis of pentalenene and pentalenolactone (1990) (94)
- Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis. (2004) (93)
- Biosynthesis of 2-methylisoborneol in cyanobacteria. (2011) (91)
- Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. (2006) (91)
- Trichodiene synthase. Probing the role of the highly conserved aspartate-rich region by site-directed mutagenesis. (1996) (90)
- Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. (2010) (88)
- Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation (2012) (88)
- Synthesis of (dl)-pentalenolactones E and F (1984) (87)
- Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases (1995) (86)
- Revisiting the modularity of modular polyketide synthases. (2009) (83)
- X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity. (2002) (82)
- Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. (1996) (82)
- Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase (2010) (82)
- Introduction: Polyketide and Nonribosomal Polypeptide Biosynthesis. From Collie to Coli. (1997) (81)
- Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. (2007) (79)
- [44] Monoterpene and sesquiterpene cyclases (1985) (77)
- Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry. (2012) (77)
- Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. (1999) (77)
- ENGINEERED BIOSYNTHESIS OF A TRIKETIDE LACTONE FROM AN INCOMPLETE MODULAR POLYKETIDE SYNTHASE (1994) (77)
- Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. (2001) (77)
- Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol. (2009) (76)
- Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site* (2009) (74)
- The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. (2006) (73)
- Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor. Mechanism and stereochemistry of the enzymatic formation of epi-isozizaene. (2009) (72)
- Understanding Substrate Specificity of Polyketide Synthase Modules by Generating Hybrid Multimodular Synthases* (2003) (71)
- Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. (2011) (71)
- The biochemical basis for stereochemical control in polyketide biosynthesis. (2009) (71)
- The stereochemistry of allylic pyrophosphate metabolism (1980) (71)
- Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway (2014) (71)
- Cyclonerodiol biosynthesis and the enzymic conversion of farnesyl to nerolidyl pyrophosphate (1981) (71)
- Structure-based dissociation of a type I polyketide synthase module. (2007) (70)
- GAIN OF FUNCTION MUTAGENESIS OF THE ERYTHROMYCIN POLYKETIDE SYNTHASE. 2. ENGINEERED BIOSYNTHESIS OF AN EIGHT-MEMBERED RING TETRAKETIDE LACTONE (1997) (70)
- Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK. (1995) (70)
- Structure and Mechanism of 2-C-Methyl-d-erythritol 2,4-Cyclodiphosphate Synthase (2002) (69)
- ALCOHOL STEREOCHEMISTRY IN POLYKETIDE BACKBONES IS CONTROLLED BY THE BETA -KETOREDUCTASE DOMAINS OF MODULAR POLYKETIDE SYNTHASES (1998) (68)
- X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis* (2008) (67)
- Synthesis of racemic .alpha.-trans- and .beta.-trans-bergamotene (1971) (67)
- Biosynthetic origin of the carbon skeleton and oxygen atoms of the avermectins (1983) (67)
- Aristolochene biosynthesis. Stereochemistry of the deprotonation steps in the enzymatic cyclization of farnesyl pyrophosphate (1990) (67)
- Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A (1981) (66)
- In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. (2013) (65)
- Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif. (2008) (65)
- Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. (2008) (65)
- Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. (2005) (65)
- Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate. (2006) (65)
- Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. (2010) (64)
- Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases. (2011) (64)
- Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase. (2000) (63)
- Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase (1996) (63)
- Nargenicin biosynthesis. Incorporation of polyketide chain elongation intermediates and support for a proposed intramolecular Diels-Alder cyclization (1993) (63)
- Isoprenoids including carotenoids and steroids (1999) (63)
- Genome mining in Streptomyces avermitilis: A biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree. (2009) (63)
- Biosynthesis of camptothecin. 3. Definition of strictosamide as the penultimate biosynthetic precursor assisted by carbon-13 and deuterium NMR spectroscopy (1979) (62)
- Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi‐isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi‐isozizaene metabolite (2011) (62)
- Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. (2003) (61)
- Programming of Erythromycin Biosynthesis by a Modular Polyketide Synthase* (2010) (61)
- Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone. (2011) (61)
- Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. (2004) (60)
- A functional chimeric modular polyketide synthase generated via domain replacement. (1996) (60)
- Pre-steady-state kinetic analysis of the trichodiene synthase reaction pathway. (1997) (60)
- Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. (2010) (59)
- Trichodiene synthase. Identification of active site residues by site-directed mutagenesis. (1995) (57)
- STEREOCHEMICAL STUDIES OF ISOPRENOID BIOSYNTHESIS. BIOSYNTHESIS OF PENTALENOLACTONE FROM (U-13C6)GLUCOSE AND (6-2H2)GLUCOSE (1981) (57)
- Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. (2005) (57)
- Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host (2015) (57)
- Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis. (2006) (57)
- Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. (2004) (56)
- Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone. (2011) (56)
- Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. (2013) (55)
- Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. (2012) (55)
- Gain-of-Function Mutagenesis of a Modular Polyketide Synthase (1997) (55)
- Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis. (2006) (55)
- Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2). (2004) (54)
- Macrolide biosynthesis. 7. Incorporation of polyketide chain elongation intermediates into methymycin (1993) (54)
- Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-)-alpha-pinene and (-)-beta-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate. (1987) (54)
- Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase (2014) (53)
- Aristolochene biosynthesis and enzymatic cyclization of farnesyl pyrophosphate (1989) (53)
- Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase. (2013) (53)
- Mechanism of the pyrophosphate migration in the enzymatic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates. (1985) (52)
- Exploring biosynthetic diversity with trichodiene synthase. (2007) (52)
- Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1 (1984) (52)
- Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. (2002) (51)
- Trichodiene biosynthesis and the stereochemistry of the enzymatic cyclization of farnesyl pyrophosphate (1985) (51)
- Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. (2002) (51)
- Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase. (2005) (51)
- BIOSYNTHESIS OF VITAMIN B6 : THE OXIDATION OF 4-(PHOSPHOHYDROXY)-L-THREONINE BY PDXA (1998) (51)
- Epicubenol Synthase and the Stereochemistry of the Enzymic Cyclization of Farnesyl and Nerolidyl Diphosphate (1995) (50)
- Macrolide biosynthesis. 3. Stereochemistry of the chain-elongation steps of erythromycin biosynthesis (1986) (50)
- Trichodiene biosynthesis and the role of nerolidyl pyrophosphate in the enzymic cyclization of farnesyl pyrophosphate (1988) (48)
- Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases (2014) (48)
- Substrate specificity of the loading didomain of the erythromycin polyketide synthase. (2000) (48)
- Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. (2003) (47)
- Probing the interactions of an acyl carrier protein domain from the 6‐deoxyerythronolide B synthase (2011) (47)
- Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate: Proof that the cyclization is catalyzed by a single enzyme (1984) (47)
- Application of carbon-13 magnetic resonance to isoprenoid biosynthesis. II. Ovalicin and the use of doubly labeled mevalonate. (1976) (47)
- Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases* (2016) (46)
- Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. (2008) (46)
- Trichodiene Synthase. Enzymatic Formation of Multiple Sesquiterpenes by Alteration of the Cyclase Active Site (1996) (46)
- Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates. (1996) (45)
- Diversity and analysis of bacterial terpene synthases. (2012) (45)
- Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor. (2001) (45)
- Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. (2001) (44)
- Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. (2017) (44)
- Macrolide biosynthesis—II : Origin of the carbon skeleton and oxygen atoms of the erythromycins (1983) (44)
- Pentalenene Synthase. Histidine-309 Is Not Required for Catalytic Activity (1999) (43)
- Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. (2008) (43)
- Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. (2016) (43)
- A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases (2016) (43)
- Synthesis of olefins from .beta.-hydroxy phosphonamides. Stereochemistry and extension to the formation of conjugated dienes (1969) (43)
- Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase. (2013) (42)
- Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. (2003) (42)
- Partial purification and characterization of pentalenene synthase. (1987) (42)
- Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase. (2016) (41)
- Enhancing the Atom Economy of Polyketide Biosynthetic Processes through Metabolic Engineering (2001) (40)
- Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene. (1988) (40)
- Stereochemical studies of isoprenoid biosynthesis. Biosynthesis of fomannosin from [1,2-13C2]acetate (1978) (40)
- Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase. (1998) (40)
- Isolation and characterization of 10-deoxymethynolide produced by Streptomyces venezuelae. (1992) (40)
- Erythromycin Biosynthesis: The β-Ketoreductase Domains Catalyze the Stereospecific Transfer of the 4-pro-S Hydride of NADPH (1998) (39)
- Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-bornyl pyrophosphate. (1986) (39)
- ENZYMIC CYCLIZATION OF GERANYL PYROPHOSPHATE TO BORNYL PYROPHOSPHATE. ROLE OF THE PYROPHOSPHATE MOIETY (1982) (38)
- Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. (2004) (38)
- Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis. (2006) (37)
- Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase. (1997) (37)
- Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone. 2. Identification of the site of alkylation by tetrahydropentalenolactone. (1994) (37)
- Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone: kinetic and mechanistic studies. (1989) (37)
- Extension of carbon chains by .gamma.-alkylation of metalated .alpha.,.beta.-ynamines (1970) (37)
- Trichodiene synthase. Synergistic inhibition by inorganic pyrophosphate and aza analogs of the bisabolyl cation. (1992) (37)
- Crystal Structure of Escherichia coli PdxA, an Enzyme Involved in the Pyridoxal Phosphate Biosynthesis Pathway* (2003) (36)
- Trichodiene synthase. Substrate specificity and inhibition. (1995) (36)
- Overproduction of soluble trichodiene synthase from Fusarium sporotrichioides in Escherichia coli. (1993) (36)
- Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate. (2012) (36)
- Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. (2015) (35)
- Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition. (2003) (35)
- 2.01 – Isoprenoid Biosynthesis: Overview (1999) (35)
- Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system (1995) (35)
- Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain. (2010) (35)
- Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis (2011) (35)
- Epicubenol synthase and the enzymic cyclization of farnesyl diphosphate (1993) (34)
- The biosynthesis of streptonigrin. 5. Biosynthesis of streptonigrin from [U-13C6]-D-glucose. Origin of the quinoline quinone (1982) (34)
- Enzymatic Formation of Isochamigrene, a Novel Sesquiterpene, by Alteration of the Aspartate-Rich Region of Trichodiene Synthase (1996) (34)
- Isolation of (-)-gamma-cadinene and aristolochene from Aspergillus terreus. (1987) (33)
- Macrolide biosynthesis. 6 Mechanism of polyketide chain elongation (1991) (33)
- Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. (2018) (33)
- Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. (1997) (33)
- Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. (2006) (33)
- High Level Expression ofRicinus communisCasbene Synthase inEscherichia coliand Characterization of the Recombinant Enzyme (1996) (33)
- Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase. (2001) (33)
- Overexpression in Escherichia coli of soluble aristolochene synthase from Penicillium roqueforti. (1993) (33)
- Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis* (2007) (32)
- Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate. (2003) (32)
- Stereochemical studies of isoprenoid biosynthesis. Biosynthesis of pentalenolactone from [U-13C6]glucose and [6-2H2]glucose (1981) (31)
- Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. (2005) (30)
- Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis of geosmin in bacteria. (2008) (30)
- Polyketide biosynthesis: molecular recognition or genetic programming? (1994) (30)
- Macrolide biosynthesis. Origin of the oxygen atoms in the erythromycins (1981) (30)
- Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange. (2013) (29)
- Thiotropocin biosynthesis. Shikimate origin of a sulfur-containing tropolone derivative (1992) (29)
- Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate. (2007) (29)
- Synthesis and Incorporation of an N-Acetylcysteamine Analogue of Methylmalonyl-CoA by a Modular Polyketide Synthase (1998) (29)
- Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange (2014) (29)
- Precursor-directed biosynthesis of 12-ethyl erythromycin. (1998) (29)
- Isolation and structure determination of pentalenolactones A, B, D, and F (1992) (28)
- Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification. (2012) (28)
- The isolation and structural elucidation of pentalenolactone E (1979) (28)
- Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. (2001) (28)
- Bergamotene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate (1981) (27)
- Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. (1998) (27)
- The biosynthesis of pentalenolactone (1979) (27)
- Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. (2008) (26)
- The enzymology of polyether biosynthesis. (2009) (26)
- Nargenicin biosynthesis: late stage oxidations and absolute configuration. (1985) (26)
- Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. (1991) (25)
- Cloning and characterization of Pfl_1841, a 2-methylenebornane synthase in Pseudomonas fluorescens PfO-1. (2011) (25)
- The Mode of Incorporation of Farnesyl Pyrophosphate into Verrucarol. Preliminary communication (1973) (24)
- Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases. (2013) (24)
- Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. (2012) (24)
- BIOSYNTHESIS OF POLYKETIDE ANTIBIOTICS. INCORPORATION OF A PENTAKETIDE CHAIN ELONGATION INTERMEDIATE INTO NARGENICIN (1995) (24)
- Trichodiene biosynthesis and the enzymatic cyclization of nerolidyl pyrophosphate (1986) (23)
- Studies of the cryptic allylic pyrophosphate isomerase activity of trichodiene synthase using the anomalous substrate 6,7-dihydrofarnesyl pyrophosphate. (1990) (23)
- Trichodiene Synthase. Stereochemical Studies of the Cryptic Allylic Diphosphate Isomerase Activity Using an Anomalous Substrate (1994) (23)
- Cyclization of farnesyl diphosphate to pentalenene. Orthogonal stereochemistry in an enzyme-catalyzed SE′ reaction (1994) (23)
- Biosynthesis of Vitamin B6: Origin of the Oxygen Atoms of Pyridoxol Phosphate (2000) (23)
- Precursor-Directed polyketide biosynthesis in Escherichia coli. (2003) (22)
- Macrolide biosynthesis. 5. Intact incorporation of a chain-elongation intermediate into nargenicin (1988) (22)
- Application of deuterium magnetic resonance to biosynthetic studies. 1. Biosynthesis of ovalicin. (1977) (22)
- Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. (2016) (22)
- Biosynthesis of (+)-epicubenol (1994) (22)
- Improved Precursor Directed Biosynthesis in E. coli via Directed Evolution (2010) (21)
- Synthesis of (+)-5-epi-aristolochene and (+)-1-deoxycapsidiol from capsidiol. (1990) (21)
- Irreversible inactivation of monoterpene cyclases by a mechanism-based inhibitor. (1993) (21)
- Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase. (1996) (20)
- Product-Mediated Regulation of Pentalenolactone Biosynthesis in Streptomyces Species by the MarR/SlyA Family Activators PenR and PntR (2013) (20)
- Aristolochene Synthase. Mechanism-Based Inhibition of a Terpenoid Cyclase (1994) (20)
- 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2. (1996) (19)
- Two distinct mechanisms for TIM barrel prenyltransferases in bacteria. (2011) (19)
- Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host. (1995) (19)
- Application of deuterium magnetic resonance to biosynthetic studies. 2. Rosenonolactone biosynthesis and stereochemistry of a biological SN2' reaction (1977) (19)
- The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism. (2016) (19)
- Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities (1999) (19)
- Enzymic cyclization of [1-18O]geranyl pyrophosphate to l-endo-fenchol (1984) (19)
- Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae. (1998) (18)
- Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. (2016) (18)
- Letter: Application of carbon-13 magnetic resonance to isoprenoid biosynthesis. I. Ovalicin. (1975) (18)
- Absolute configuration of (-)-.beta.-trans-bergamotene (1990) (17)
- The synthesis of (3R)-nerolidol (1990) (17)
- Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate. Inversion at C-1 during 11-membered-ring formation (1988) (17)
- The biosynthesis of ovalicin from β-trans-bergamotene (1987) (17)
- Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. (2003) (17)
- Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. (2004) (16)
- Selection of a specifically blocked mutant of Streptomyces cinnamonensis: isolation and synthesis of 26-deoxymonensin A. (1989) (16)
- Thiotropocin Biosynthesis. Shikimate Origin of a Sulfur-Containing Tropolone Derivative. (1993) (16)
- Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. (2017) (15)
- Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction (1988) (15)
- Synthesis of proposed chain-elongation intermediates of the monensin biosynthetic pathway (1988) (14)
- Precursor‐Directed Biosynthesis: Stereospecificity for Branched‐Chain Diketides of the β‐Ketoacyl‐ACP Synthase Domain 2 of 6‐Deoxyerythronolide B Synthase (2003) (14)
- Biosynthesis of macrolide antibiotics. 4. Stereochemistry of hydrogen labeling of brefeldin A by [2-2H3]acetate (1981) (14)
- Monoterpene cyclization mechanisms and the use of natural abundance deuterium NMR-short cut or primrose path ? (1993) (14)
- Controlled hydroxymethylation of ketones (1971) (14)
- Biosynthesis Meets Bioinformatics (2000) (14)
- METHYMYCIN BIOSYNTHESIS. ISOLATION OF P450 MONOOXYGENASE ACTIVITY IN A CELL-FREE SYSTEM FROM STREPTOMYCES VENEZUELAE (1998) (14)
- Crystallization and preliminary X‐ray diffraction analysis of recombinant pentalenene synthase (1995) (13)
- Preparation of (−)-aristolochene from (+)-valencene: Absolute configuration of (+)-aristolochene from aspergillus terreus. (1990) (13)
- Recognition of Acyl Carrier Proteins by Ketoreductases in Assembly Line Polyketide Synthases (2016) (13)
- Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase. (2012) (13)
- Biosynthesis of cyclonerodiol (1978) (13)
- Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. (2017) (13)
- PENTALENENE BIOSYNTHESIS AND THE ENZYMIC CYCLIZATION OF FARNESYL PYROPHOSPHATE (1983) (13)
- Stereochemical studies of natural products biosynthesis (1989) (13)
- Dissecting the Evolutionary Relationship between 14-Membered and 16-Membered Macrolides (1998) (12)
- Polyether biosynthesis. III: Origin of the carbon skeleton and oxygen atoms of lenoremycin (1987) (12)
- Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. (2005) (12)
- The biosynthesis of quadrone and terrecyclic acid (1984) (12)
- Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. (2017) (12)
- Pentalenolactone F, a new metabolite isolated from streptomyces. Isolation and structure elucidation. (1983) (12)
- The enzymic conversion of farnesyl to nerolidyl pyrophosphate: role of the pyrophosphate moiety (1979) (12)
- Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate. (2002) (11)
- The biosynthesis of ovalicin: Isolation of β--bergamotene (1976) (11)
- Biosynthesis of fomannosin from 1,2-13C-acetate (1976) (11)
- The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene. (2016) (11)
- Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases. (2018) (10)
- Specificity and versatility in erythromycin biosynthesis (1997) (10)
- High level expression of Ricinus communis casbene synthase in Escherichia coli and characterization of the recombinant enzyme. (1996) (10)
- Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase. (2017) (10)
- Epicubenol synthase. Origin of the oxygen atom of a bacterial sesquiterpene alcohol. (2000) (10)
- Substitution of a Single Amino Acid Reverses the Regiospecificity of the Baeyer-Villiger Monooxygenase PntE in the Biosynthesis of the Antibiotic Pentalenolactone. (2016) (10)
- Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase. (2013) (10)
- Trichodiene synthase: mechanism-based inhibition of a sesquiterpene cyclase. (1999) (9)
- Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. (2017) (9)
- pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism. (2018) (9)
- Epicubenol Synthase and the Stereochemistry of the Enzymatic Cyclization of Farnesyl and Nerolidyl Diphosphate. (1995) (9)
- Aristolochene Synthase. Elucidation of the Cryptic Germacrene A Synthase Activity Using the Anomalous Substrate Dihydrofarnesyl Diphosphate. (1997) (8)
- The absolute configuration of fomannosin (1977) (8)
- Cyclonerodiol biosynthesis and the stereochemistry of the conversion of farnesyl to nerolidyl pyrophosphate (1978) (8)
- Precursor‐Directed Biosynthesis of Erythromycin Analogues by an Engineered Polyketide Synthase (1997) (8)
- Conversion of farnesyl and nerolidyl pyrophosphate to cyclonerodiol by a cell-free extract from Gibberella fujikuroi (1978) (6)
- The X-ray crystal structure of pentalenolactone F methyl ester (epi-pentalenolactone F). (1988) (6)
- Incubation of 2-Methylisoborneol Synthase with the Intermediate Analogue 2-Methylneryl Diphosphate (2017) (6)
- Additions and Corrections - Stereochemical Studies of Isoprenoid Biosynthesis of Fomannosin from [1,2-13C2]Acetate (1979) (6)
- Biosynthesis of fomannosin. 2H NMR evidence against postulated hydride shifts (1980) (5)
- Cell-free studies of monoterpene and sesquiterpene biosynthesis. (1983) (5)
- Trichodiene Biosynthesis and the Enzymatic Cyclization of Nerolidyl Pyrophosphate. (1986) (5)
- Faculty Opinions recommendation of The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. (2006) (5)
- Sesquiterpene biosynthesis: The biosynthesis of quadrone and terrecyclic acid (1986) (5)
- STEREOCHEMICAL STUDIES OF ISOPRENOID BIOSYNTHESIS. BIOSYNTHESIS OF FOMANNOSIN FROM (1,2-13C2)ACETATE (1978) (4)
- 2 H n.m.r. determination of the stereochemistry of an allylic displacement in the biosynthesis of virescenol B (1981) (4)
- Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2. (2006) (4)
- Total synthesis of (±)-epicubenol (1994) (4)
- Prelog Lecture: Mechanism and Structure of Biosynthetic Enzymes. The Biosynthesis of Vitamin B6 (2003) (3)
- CRYSTAL STRUCTURE OF THE APO FORM OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHETASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS (2001) (3)
- Nature as organic chemist (2016) (3)
- APPLICATION OF CARBON-13 MAGNETIC RESONANCE TO ISOPRENOID BIOSYNTHESIS PART 1, OVALICIN (1975) (3)
- Enzyme-level studies of the biosynthesis of natural products (1984) (3)
- Carboncarbon bond cleavage during lithium aluminum hydride reduction of a terminal propargyl alcohol (1979) (3)
- Terpenoid cyclases: design and function of electrophilic catalysts. (1992) (3)
- Brushes with sage. (2006) (2)
- , Permutations , and Mutations Harnessing the Biosynthetic Code : Combinations (2008) (2)
- Stereochemical Studies of Natural Products Biosynthesis a (1986) (2)
- Isoprenoid antibiotics. (1995) (2)
- Nargenicin Biosynthesis. Incorporation of Polyketide Chain Elongation Intermediates and Support for a Proposed Intramolecular Diels‐Alder Cyclization. (2010) (2)
- CRYSTAL STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS (2001) (2)
- Absolute Configuration of (-)-β-trans-Bergamotene. (1990) (1)
- BIOSYNTHESIS ORIGIN OF THE CARBON SKELETON AND OXYGEN ATOMS OF NARGENICIN A1 (1984) (1)
- Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) (2002) (1)
- Back to basics; assigning biochemical function in the post-genomic era. (2004) (1)
- CRYSTAL STRUCTURE OF ARISTOLOCHENE SYNTHASE FROM PENICILLIUM ROQUEFORTI (2000) (1)
- Perspectives: biosynthetic pathways. Biosynthesis meets bioinformatics. (2000) (1)
- Erratum to “Molecular cloning, expression and characterization of the first three genes in the mevalonate-Independent isoprenoid pathway in Streptomyces Coelicolor” [Bioorg. Med. Chem. 9 (2001) 1467] (2001) (1)
- Trichodiene Synthase from Fusarium Sporotrichioides (2001) (1)
- Crystal structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2) (2013) (0)
- X-ray Structure of F232L mutant of Cytochrome P450 PntM with pentalenolactone F (2016) (0)
- Total Synthesis of (.+-.)-Epicubenol. (1994) (0)
- THEORETICAL MODEL OF THE COMPLEX OF ARISTOLOCHENE SYNTHASE AND EUDESMANE CATION (2000) (0)
- Exploring the Bacterial Terpenome (2012) (0)
- Crystal structure of Aspergillus terreus aristolochene synthase N299A complexed with farnesyl thiolodiphosphate (2013) (0)
- N225D trichodiene synthase (2007) (0)
- ENZYMIC CYCLIZATION OF (1-18O)GERANYL PYROPHOSPHATE TO L-ENDO-FENCHOL (1984) (0)
- Enzymatic Formation of Isochamigrene, a Novel Sesquiterpene, by Alteration of the Aspartate-Rich Region of Trichodiene Synthase J. Am. Chem. Soc. 1996, 118, 8499−8500 (1997) (0)
- X-ray Structure of 2-Mercaptoethanol modified M81C mutant of Cytochrome P450 PntM with pentalenolactone F (2016) (0)
- D100E trichodiene synthase (2002) (0)
- APPLICATION OF DEUTERIUM MAGNETIC RESONANCE TO BIOSYNTHETIC STUDIES. 1. BIOSYNTHESIS OF OVALICIN (1977) (0)
- Crystal structure of the dehydratase domain from the terminal module of the rifamycin polyketide synthase (2013) (0)
- Crystal Structure of PtlH with Fe/oxalylglycine and ent-1-deoxypentalenic acid bound (2007) (0)
- Geosmin synthase from Streptomyces coelicolor N-terminal domain complexed with three Mg2+ ions and alendronic acid (2015) (0)
- R304K trichodiene synthase (2005) (0)
- Faculty Opinions recommendation of The crystal structure of a mammalian fatty acid synthase. (2008) (0)
- Probabilistic precipitation forecast obtained with Multimodel Dressing and its hydrological applications (2010) (0)
- The absolute configuration of cyclonerodiol (1977) (0)
- Theoretical Model of Germacrene in the Active Site of Aristolochene Synthase (2000) (0)
- Biosynthesis of (+)-Epicubenol. (1994) (0)
- Crystal structure of N299A Aspergillus terreus aristolochene synthase complexed with (1S,8S,9aR)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium (2013) (0)
- Theoretical Model of Aristolochene Synthase Complexed With Its Substrate, Farnesyl Diphosphate (2000) (0)
- Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6 (2003) (0)
- CARBON‐CARBON BOND CLEAVAGE DURING LITHIUM ALUMINUM HYDRIDE REDUCTION OF A TERMINAL PROPARGYL ALCOHOL (1979) (0)
- Enzymes, coenzymes and metabolic pathways July 14–18, 1996 Kimball Union Academy Meriden, NH, USA (1996) (0)
- Family Activators PenR and PntR Streptomyces Species by the MarR/SlyA Pentalenolactone Biosynthesis in Product-Mediated Regulation of (2013) (0)
- Genome Mining in Streptomyces clavuligerus. Expression and Biochemical Characterization of Two Cryptic Sesquiterpene Cyclases, (−)-δ-Cadinene Synthase and (+)-T-Muurolol Synthase (2011) (0)
- Crystal Structure of PtlH with AKG and ent-1PL bound (2007) (0)
- Faculty Opinions recommendation of Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. (2004) (0)
- D100E trichodiene synthase complexed with pyrophosphate (2002) (0)
- Epi-isozizaene synthase complexed with Hg (2010) (0)
- X-ray Structure of Cytochrome P450 PntM with Dihydropentalenolactone F (2016) (0)
- Crystal structure of aristolochene synthase in complex with 12,13-difluorofarnesyl diphosphate (2008) (0)
- Crystal structure of Aspergillus terreus aristolochene synthase complexed with (4aS,7S)-4a-methyl-7-(prop-1-en-2-yl)-2,3,4,4a,5,6,7,8-octahydroquinolin-1-ium (2013) (0)
- CRYSTAL STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHETASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS, COMPLEXED WITH CDP-ME AND MG2+ (2001) (0)
- 1.96 A Crystal Structure of Pyridoxine 5'-Phosphate Synthase in Complex with 1-deoxy-D-xylulose phosphate (2003) (0)
- New technique for ensemble dressing combining Multimodel SuperEnsemble and precipitation PDF (2009) (0)
- Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli involved in Mevalonate-Independent Isoprenoid Biosynthesis (2002) (0)
- The enzymology of the biosynthesis of natural products (1990) (0)
- THE JOURNAL OF ANTIBIOTICS NARGENICIN BIOSYNTHESIS: LATE STAGE OXIDATIONS AND ABSOLUTE CONFIGURATION (2006) (0)
- Y295F trichodiene synthase (2007) (0)
- Co-Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli Involved in Mevalonate-Independent Isoprenoid Biosynthesis, Complexed with CMP/MECDP/Mn2+ (2002) (0)
- Macrolide Biosynthesis. Part 7. Incorporation of Polyketide Chain Elongation Intermediates into Methymycin. (1993) (0)
- Aristolochene synthase from Aspergillus terreus complexed with pyrophosphate (2007) (0)
- W325F Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate (2013) (0)
- Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0 (2003) (0)
- THEORETICAL MODEL OF THE ENZYME-PRODUCT COMPLEX OF ARISTOLOCHENE SYNTHASE (2000) (0)
- Faculty Opinions recommendation of Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. (2007) (0)
- How to evolve a silk purse from a sow's ear (2006) (0)
- Crystal Structure of PtlH with Fe/oxalylglycine bound (2007) (0)
- Structural and Mechanistic Analysis of Trichodiene Synthase using Site-Directed Mutagenesis: Probing the Catalytic Function of Tyrosine-295 and the Asparagine-225/Serine-229/ Glutamate-233–Mg 2+B Motif, I,II (2008) (0)
- Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4 (2003) (0)
- BIOSYNTHESIS OF CYCLONERODIOL: STEREOCHEMISTRY OF THE CONVERSION OF FARNESYL TO NEROLIDYL PYROPHOSPHATE (1979) (0)
- ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX (2001) (0)
- X-ray Structure of the Substrate-free Cytochrome P450 PntM (2016) (0)
- D100E Trichodiene Synthase: Complex With Mg, Pyrophosphate, and (4R)-7-azabisabolene (2005) (0)
- Fighting Fascism in Europe (2003) (0)
- Crystal structure of E.coli PdxA (2003) (0)
- N225D Trichodiene Synthase: Complex With Mg and Pyrophosphate (2007) (0)
- Y305F Trichodiene Synthase (2005) (0)
- Crystal Structure of PtlH with Fe/alpha ketoglutarate bound (2007) (0)
- A236G Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation (2013) (0)
- Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS. (2006) (0)
- Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5 (2003) (0)
- Faculty Opinions recommendation of Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway. (2005) (0)
- TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE (2001) (0)
- Crystal structure of the unliganded geosmin synthase N-terminal domain from Streptomyces coelicolor (2015) (0)
- Trichodiene synthase: Complex with inorganic pyrophosphate resulting from the reaction with 2-fluorofarnesyl diphosphate (2007) (0)
- N225D/S229T trichodiene synthase (2007) (0)
- N219L PENTALENENE SYNTHASE (2002) (0)
- Biochemistry: Favouring the unfavoured (2012) (0)
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