David A. Eisner

Q: What Schools Are Affiliated With David A. Eisner

David A. Eisner is affiliated with the following schools: University of Liverpool, University College London, University of Manchester

David A. Eisner's AcademicInfluence.com Rankings

David A. Eisner

Biology

#1522

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#2527

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Physiology

#21

World Rank

#79

Historical Rank

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Biology

Why Is David A. Eisner Influential?

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According to Wikipedia, David Alfred Eisner, FRCP , FMedSci, is British Heart Foundation Professor of Cardiac Physiology at the University of Manchester and editor-in-chief of The Journal of General Physiology . Education Eisner was born in 1955 in Manchester, the son of the physicist and writer Herbert Eisner. After attending Manchester Grammar School, he received his B.A. in natural sciences at King's College, Cambridge in 1976. In 1979 he obtained a D.Phil. in physiology at Oxford University in the laboratory of Denis Noble for work on the sodium pump in cardiac muscle.

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David A. Eisner's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Calcium and Excitation-Contraction Coupling in the Heart (2017) (405)
Integrative Analysis of Calcium Cycling in Cardiac Muscle (2000) (319)
Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans (2004) (314)
Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. (2003) (277)
Oscillations of intracellular Ca2+ in mammalian cardiac muscle (1983) (269)
Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. (2007) (258)
Na-Ca exchange: stoichiometry and electrogenicity. (1985) (244)
Ca2+ ions can affect intracellular pH in mammalian cardiac muscle (1983) (219)
Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal Ca2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release (1997) (218)
The sarcoplasmic reticulum and arrhythmogenic calcium release. (2008) (210)
The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. (1989) (208)
The steady state TTX-sensitive (“window”) sodium current in cardiac Purkinje fibres (1979) (207)
The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation. (1998) (206)
Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium Waves: Threshold Sarcoplasmic Reticulum Calcium Content Is Required (2007) (203)
Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes (2000) (193)
The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes. (1993) (189)
Regulation of Intracellular and Mitochondrial Sodium in Health and Disease (2009) (178)
Inotropic and arrhythmogenic effects of potassium‐depleted solutions on mammalian cardiac muscle. (1979) (175)
Depressed Ryanodine Receptor Activity Increases Variability and Duration of the Systolic Ca2+ Transient in Rat Ventricular Myocytes (2002) (169)
Characterization of the electrogenic sodium pump in cardiac Purkinje fibres (1980) (158)
The dependence of sodium pumping and tension on intracellular sodium activity in voltage‐clamped sheep Purkinje fibres. (1981) (157)
A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes (1999) (157)
Fluorescence measurements of cytoplasmic and mitochondrial sodium concentration in rat ventricular myocytes. (1992) (149)
Characterization of an Extensive Transverse Tubular Network in Sheep Atrial Myocytes and its Depletion in Heart Failure (2009) (141)
An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes (1993) (140)
Transverse tubules are a common feature in large mammalian atrial myocytes including human. (2011) (140)
The control of tonic tension by membrane potential and intracellular sodium activity in the sheep cardiac Purkinje fibre. (1983) (138)
Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. (1995) (137)
Characterization of oscillations of intracellular calcium concentration in ferret ventricular muscle. (1984) (137)
Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones. (1990) (135)
Caffeine inhibits the agonist-evoked cytosolic Ca2+ signal in mouse pancreatic acinar cells by blocking inositol trisphosphate production. (1992) (132)
Coordinated Control of Cell Ca2+ Loading and Triggered Release From the Sarcoplasmic Reticulum Underlies the Rapid Inotropic Response to Increased L-Type Ca2+ Current (2001) (131)
The quantitative relationship between twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres. (1984) (130)
The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurement of [Ca2+]i and [caffeine]i. (1990) (130)
Enhanced Ca2+ current and decreased Ca2+ efflux restore sarcoplasmic reticulum Ca2+ content after depletion. (1997) (127)
A mechanism for the effects of caffeine on Ca2+ release during diastole and systole in isolated rat ventricular myocytes. (1990) (118)
The New Volunteer Workforce (2009) (116)
The relationship between intracellular calcium and contraction in calcium‐overloaded ferret papillary muscles. (1985) (113)
The effects of low sodium solutions on intracellular calcium concentration and tension in ferret ventricular muscle. (1983) (109)
Calcium flux balance in the heart. (2013) (109)
The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes. (2000) (105)
Sarcoplasmic Reticulum Ca 2 and Heart Failure Roles of Diastolic Leak and Ca 2 Transport (2003) (103)
Estimate of net calcium fluxes and sarcoplasmic reticulum calcium content during systole in rat ventricular myocytes. (1995) (102)
In the RyR2R4496C Mouse Model of CPVT, &bgr;-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves (2010) (102)
Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1) (2014) (101)
Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic [Ca2+] in rat uterine smooth muscle cells (2001) (98)
Measurements of intracellular Ca2+ in dissociated type I cells of the rabbit carotid body. (1989) (96)
The control of sarcoplasmic reticulum Ca content in cardiac muscle. (2005) (96)
Reducing Ryanodine Receptor Open Probability as a Means to Abolish Spontaneous Ca2+ Release and Increase Ca2+ Transient Amplitude in Adult Ventricular Myocytes (2006) (96)
What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? (2009) (96)
The effects of heart rate on the action potential of guinea‐pig and human ventricular muscle. (1981) (95)
The role of sarcolemmal Ca2+‐ATPase in the regulation of resting calcium concentration in rat ventricular myocytes (1999) (95)
Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. (1992) (94)
Voltage clamp and tracer flux data: effects of a restricted extra-cellular space (1979) (94)
The effect of tetracaine on supontaneous Ca2+ release and sarcoplasmic reticulum calcium content in rat ventricular myocytes (1997) (91)
Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure (2018) (90)
Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart. (2007) (89)
Properties of voltage‐activated [Ca2+]i transients in single smooth muscle cells isolated from pregnant rat uterus (1998) (88)
The effect of tetracaine on stimulated contractions, sarcoplasmic reticulum Ca2+ content and membrane current in isolated rat ventricular myocytes (1998) (87)
The effect of acidosis on systolic Ca2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes (2000) (87)
The dependence on heart rate of the human ventricular action potential duration. (1982) (86)
Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After &bgr;-Adrenergic Stimulation (2013) (82)
Mechanisms underlying enhanced cardiac excitation contraction coupling observed in the senescent sheep myocardium. (2004) (82)
The effects of rubidium ions and membrane potentials on the intracellular sodium activity of sheep Purkinje fibres. (1981) (79)
Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle. (1984) (77)
The effect of tetracaine on spontaneous Ca2+ release and sarcoplasmic reticulum calcium content in rat ventricular myocytes. (1997) (77)
Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation-contraction coupling. (2008) (75)
Effects of changes of intracellular pH on contraction in sheep cardiac Purkinje fibers (1987) (74)
Stability and instability of regulation of intracellular calcium (2005) (74)
From the ryanodine receptor to cardiac arrhythmias. (2009) (73)
The role of the sarcoplasmic reticulum as a Ca2+ sink in rat uterine smooth muscle cells (1999) (73)
The role of intracellular sodium activity in the anti‐arrhythmic action of local anaesthetics in sheep Purkinje fibres. (1983) (72)
Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L‐type Ca2+ current and diastolic [Ca2+]i (2007) (70)
The effects of inhibitors of sarcoplasmic reticulum function on the systolic Ca2+ transient in rat ventricular myocytes. (1993) (64)
The Control of Diastolic Calcium in the Heart (2020) (62)
How calcium signals in myocytes and pericytes are integrated across in situ microvascular networks and control microvascular tone☆ (2013) (61)
Na/Ca Exchange (2007) (61)
Effects of rapid application of caffeine on intracellular calcium concentration in ferret papillary muscles (1988) (60)
A study of intracellular calcium oscillations in sheep cardiac Purkinje fibres measured at the single cell level. (1986) (60)
Metabolic consequences of increasing intracellular calcium and force production in perfused ferret hearts. (1986) (56)
Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. (1995) (55)
Sodium calcium exchange as a target for antiarrhythmic therapy. (2006) (54)
Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca. (1998) (54)
Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes (2004) (53)
Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes (2011) (53)
A DNA antigen that reacts with antisera to cardiolipin. (1974) (52)
The relationship between sodium pump activity and twitch tension in cardiac Purkinje fibres (1980) (52)
Na/Ca exchange: regulator of intracellular calcium and source of arrhythmias in the heart. (2007) (50)
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes. (2010) (50)
Calcium Buffering in the Heart in Health and Disease (2019) (49)
Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias. (2013) (49)
Altered Cardiac Sarcoplasmic Reticulum Function of Intact Myocytes of Rat Ventricle During Metabolic Inhibition (2001) (49)
Local activation of contraction in isolated rat ventricular myocytes. (1990) (48)
A new technique for simultaneous and in situ measurements of Ca2+ signals in arteriolar smooth muscle and endothelial cells. (2003) (48)
The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate (2009) (47)
Impaired β‐adrenergic responsiveness accentuates dysfunctional excitation–contraction coupling in an ovine model of tachypacing‐induced heart failure (2011) (47)
Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes (1998) (47)
Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study. (2008) (47)
Calcium in the heart: from physiology to disease (2014) (47)
Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current (2015) (46)
Carboxyeosin decreases the rate of decay of the [Ca2+]i transient in uterine smooth muscle cells isolated from pregnant rats (1998) (46)
Integrative analysis of calcium signalling in cardiac muscle. (2002) (46)
The effects of ryanodine on calcium-overloaded sheep cardiac Purkinje fibers. (1985) (46)
Cardiac Na‐Ca Exchange and pH (1996) (46)
Alternans of intracellular calcium: mechanism and significance. (2006) (45)
Enhanced calcium current and decreased calcium efflux restore sarcoplasmic reticulum Ca content following depletion (1997) (45)
Effects of metabolic inhibition and changes of intracellular pH on potassium permeability and contraction of rat uterus. (1993) (45)
A novel method for absolute calibration of intracellular pH indicators (1989) (43)
Effects of caffeine, tetracaine, and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibers (1985) (42)
The interaction of potassium ions and ATP on the sodium pump of resealed red cell ghosts. (1981) (42)
The contribution of intracellular acidosis to the decline of developed pressure in ferret hearts exposed to cyanide. (1987) (42)
The mechanism of the increase of tonic tension produced by caffeine in sheep cardiac Purkinje fibres. (1985) (42)
The effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytes (2009) (42)
2,3-Butanedione monoxime (BDM) decreases sarcoplasmic reticulum Ca content by stimulating Ca release in isolated rat ventricular myocytes (1998) (41)
Effects of mefloquine on cardiac contractility and electrical activity in vivo, in isolated cardiac preparations, and in single ventricular myocytes (2000) (41)
The effects of inhibition of the sarcolemmal Ca-ATPase on systolic calcium fluxes and intracellular calcium concentration in rat ventricular myocytes (1999) (40)
Control of intracellular ionized calcium concentration by sarcolemmal and intracellular mechanisms. (1984) (40)
A measurable reduction of s.r. Ca content follows spontaneous Ca release in rat ventricular myocytes (1997) (40)
The effects of sodium pump activity on the slow inward current in sheep cardiac Purkinje fibres (1982) (39)
The effects of exogenous calcium buffers on the systolic calcium transient in rat ventricular myocytes. (2001) (38)
Factors controlling changes in intracellular Ca2+ concentration produced by noradrenaline in rat mesenteric artery smooth muscle cells. (1995) (38)
Sodium pump: Birthday present for digitalis (1985) (37)
Do calcium-activated potassium channels exist in the heart? (1983) (37)
The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes (2001) (37)
Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study. (2012) (37)
Physiological and pathological modulation of ryanodine receptor function in cardiac muscle. (2004) (37)
Variability of spontaneous Ca2+ release between different rat ventricular myocytes is correlated with Na(+)-Ca2+ exchange and [Na+]i. (1996) (36)
A functional role for transverse (t-) tubules in the atria. (2013) (36)
Properties of the Fluorescent Sodium Indicator SBFI in Rat and Rabbit Cardiac Myocytes (1994) (35)
Changes of intracellular [Ca2+] during refilling of sarcoplasmic reticulum in rat ventricular and vascular smooth muscle. (1993) (35)
Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes (2014) (34)
The Contribution of Na‐Ca Exchange to Relaxation in Mammalian Cardiac Muscle a (1991) (33)
No Role for the Ryanodine Receptor in Regulating Cardiac Contraction? (2000) (33)
Calcium Handling Defects and Cardiac Arrhythmia Syndromes (2020) (33)
Something old, something new: changing views on the cellular mechanisms of heart failure. (2005) (32)
Sarcoplasmic Reticulum Ca-ATPase and Heart Failure 20 Years Later (2013) (31)
Sodium calcium exchange in the heart: necessity or luxury? (2004) (31)
The role of the sarcolemmal Ca2+ ‐ATPase in the pH transients associated with contraction in rat smooth muscle (1997) (31)
Caffeine and tetracaine abolish the slow inward calcium current in sheep cardiac Purkinje fibres [proceedings]. (1979) (31)
Measurement of calcium entry and exit in quiescent rat ventricular myocytes (2000) (30)
The influence of chemical agents on the level of ionized [Ca2+] in squid axons (1985) (30)
The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte. (2010) (30)
Properties of the fluorescent sodium indicator SBFI in rat and rabbit cardiac myocytes. (1994) (29)
Heart Failure and the Ryanodine Receptor: Does Occam’s Razor Rule? (2002) (29)
How Structure, Ca Signals, and Cellular Communications Underlie Function in Precapillary Arterioles (2009) (28)
Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart. (1993) (28)
Pseudoreplication in physiology: More means less (2021) (28)
Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions (2014) (27)
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content. (2011) (27)
Calcium-induced calcium release activates contraction in intact cardiac cells (1989) (26)
A mechanism distinct from the L-type Ca current or Na-Ca exchange contributes to Ca entry in rat ventricular myocytes. (2006) (25)
Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak (2016) (25)
Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure (2018) (25)
The effects of membrane potential on active and passive sodium transport in Xenopus oocytes. (1987) (24)
Simultaneous measurement of intracellular pH, calcium, and tension in rat mesenteric vessels: effects of extracellular pH. (1996) (23)
Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes (1993) (22)
Life, sudden death, and intracellular calcium. (2006) (21)
Ups and downs of calcium in the heart (2018) (21)
Screening and prevention in Swiss primary care: a systematic review (2011) (20)
Disruption of Pressure-Induced Ca2+ Spark Vasoregulation of Resistance Arteries, Rather Than Endothelial Dysfunction, Underlies Obesity-Related Hypertension (2019) (19)
The effects of inhibitors of sarcoplasmic reticulum function on the size and time course of the systolic Ca transient in rat ventricular myocytes (1993) (19)
Comparison of the effects of caffeine and other methylxanthines on [Ca2+]i in rat ventricular myocytes (1994) (19)
Membrane potential and ion concentration stability conditions for a cell with a restricted extracellular space (1979) (18)
Systolic [Ca2+]i regulates diastolic levels in rat ventricular myocytes (2017) (18)
Changes of pH affect calcium currents but not outward potassium currents in rat myometrial cells (1995) (18)
Inhibition of the sodium pump by inorganic phosphate in resealed red cell ghosts. (1982) (18)
The effects of changing intracellular pH on calcium and potassium currents in smooth muscle cells from the guinea-pig ureter (1998) (17)
No role for a voltage sensitive release mechanism in cardiac muscle. (2002) (16)
Low sodium inotropy is accompanied by diastolic Ca2+ gain and systolic loss in isolated guinea‐pig ventricular myocytes (2001) (16)
Two hundred years of the foxglove. (1985) (16)
The action of adrenaline on pace‐maker activity in cardiac Purkinje fibres. (1978) (16)
Effects of membrane potential on intracellular calcium concentration in sheep Purkinje fibres in sodium‐free solutions. (1986) (15)
Normal and pathological excitation–contraction coupling in the heart – an overview (2003) (14)
Discrete membrane surface charge distributions. Effect of fluctuations near individual channels. (1978) (14)
The role of intracellular Ca ions in the therapeutic and toxic effects of cardiac glycosides and catecholamines. (1986) (14)
A comparison of measurements of intracellular Ca by Ca electrode and optical indicators. (1984) (14)
The effects of nickel on contraction and membrane current in isolated rat myocytes. (1988) (14)
Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep (2018) (14)
Strophanthidin-induced gain of Ca2+ occurs during diastole and not systole in guinea-pig ventricular myocytes (1999) (14)
Active transport and inotropic state in guinea pig left atrium. (1983) (13)
The effects of intracellular Na on contraction and intracellular pH in mammalian cardiac muscle. (1985) (12)
Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of a Ca fluxes and sr Ca (1998) (12)
Excitation-Contraction Coupling in Cardiac Muscle (2002) (12)
The effects of thapsigargin on [Ca2+]i in isolated rat mesenteric artery vascular smooth muscle cells (2004) (11)
Measurement of Sarcoplasmic Reticulum Ca Content and Sarcolemmal Fluxes during the Transient Stimulation of the Systolic Ca Transient Produced by Caffeine (1998) (11)
Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes (2017) (10)
Stimulation and inhibition by ATP and orthophosphate of the potassium‐potassium exchange in resealed red cell ghosts. (1983) (10)
Birthday present for digitalis. (1985) (10)
Thick slurry bevelling (1979) (9)
The sarcolemmal mechanisms involved in the control of diastolic intracellular calcium in isolated rat cardiac trabeculae (1996) (9)
Illuminating sarcoplasmic reticulum calcium. (2003) (9)
Do calcium waves propagate between cells and synchronize alternating calcium release in rat ventricular myocytes? (2012) (8)
Calsequestrin mutations and sudden death: a case of too little sarcoplasmic reticulum calcium buffering? (2008) (8)
A small leak may sink a great ship but what does it do to the heart? (2010) (7)
THE EFFECTS OF GLUCOSE REMOVAL AND CYANIDE ON INTRACELLULAR CA-2+ IN ISOLATED, SINGLE-MOUSE DORSAL-ROOT GANGLION-CELLS (1988) (7)
The electrogenic Na pump in mammalian cardiac muscle. (1984) (7)
Beating to time: calcium clocks, voltage clocks, and cardiac pacemaker activity. (2009) (7)
Two centuries of excitation-contraction coupling. (2004) (7)
The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca2+ handling in rat ventricular myocytes (2015) (7)
The effects of lactic acid production on contraction and intracellular pH during hypoxia in cardiac muscle (1993) (7)
Sarcoplasmic reticulum and mitochondria in cardiac pathophysiology. (2008) (6)
Measurement of intracellular calcium during the development and relaxation of tonic tension in sheep Purkinje fibres. (1986) (6)
Blockade of sodium‑calcium exchanger via ORM-10962 attenuates cardiac alternans (2020) (6)
Variability of spontaneous Ca release between different rat ventricular myocytes is correlated with NA-Ca exchange and intracellular Na concentration (1996) (6)
8 – The Regulation of Tension in Heart Muscle by Intracellular Sodium (1986) (6)
Can changes of ryanodine receptor expression affect cardiac contractility? (2000) (6)
How does endothelin-1 cause a sustained increase in intracellular sodium and calcium which lead to hypertrophy? (2006) (6)
Activity dependent changes in mammalian ventricular muscle [proceedings]. (1977) (6)
Electrophysiological effects of cardiac glycosides (1986) (6)
Arrhythmogenic effects of hypokalaemia on mammalian ventricular muscle [proceedings]. (1978) (6)
CYANIDE INCREASES [CA-2+]I IN ISOLATED TYPE-I CELLS FROM THE RABBIT CAROTID-BODY (1988) (5)
The effects of Na-Ca exchange on membrane currents in sheep cardiac Purkinje fibers. (1984) (5)
What is the purpose of the large sarcolemmal calcium flux on each heartbeat? (2009) (5)
Roles of Diastolic Leak and Ca Transport (2003) (5)
Writing a peer review: a primer for junior researchers. (2019) (5)
How does CaMKIIδ phosphorylation of the cardiac ryanodine receptor contribute to inotropy? (2010) (5)
The quantitative relationship between intracellular Na activity and tension in sheep cardiac Purkinje fibres (1984) (5)
A tale of two leaks. (2013) (4)
A model model: a commentary on DiFrancesco and Noble (1985) ‘A model of cardiac electrical activity incorporating ionic pumps and concentration changes’ (2015) (4)
A new Technique for Bevelling Extremely Fine Mieroeleetrodes and Mieropipettes (1979) (4)
The Electrogenic Na-K Pump in the Sheep Cardiac Purkinje Fibre (1981) (4)
Misleading with citation statistics? (2019) (4)
Ion pumping in biological membranes (1985) (4)
Another trigger for the heartbeat (1998) (4)
A sideways look at sparks, quarks, puffs and blips. (1996) (4)
A cellular basis for lidocaine's anti-arrhythmic action [proceedings]. (1979) (3)
PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca2+ Content (2021) (3)
Handing Over. (2016) (3)
Effect of metabolic blockade on intracellular sodium in isolated rat ventricular myocytes (1990) (3)
The ryanodine receptor: cause or consequence of diabetic heart failure? (2000) (3)
Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart (2022) (3)
Does the cardioprotective effect of Empagliflozin involve inhibition of the sodium-proton exchanger? (2021) (3)
Chronic vagal nerve stimulation has no effect on tachycardia‐induced heart failure progression or excitation–contraction coupling (2020) (3)
A study of intracellular calcium oscillations in sheep cardiac Purkinje fires (1986) (3)
Effects of Sodium Pump Inhibition on Contraction in Sheep Cardiac Purkinje Fibers (1983) (3)
Building Democracy through Service (2005) (2)
Increased ICaL Underlies Ventricular Action-Potential Prolongation After Spontaneous Ca2+ Release From The Sarcoplasmic Reticulum (2011) (2)
Comments on " Active Transport and Inotropic State in Guinea Pig Left (2)
Intracellular Calcium Regulation. Edited by Felix Bronner. Pp. 480. Wiley‐Liss, New York, 1990. $79.50 hardback. ISBN 0‐471‐56216‐5 (1991) (2)
PH-induced changes in calcium: functional consequences and mechanisms of action in guinea pig portal vein. (2002) (2)
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle (2022) (2)
Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia (1988) (2)
Low-potassium inotropy in cardiac muscle [proceedings]. (1978) (2)
Does sodium pump inhibition produce the positive inotropic effects of strophanthidine in mammalian cardiac muscle? [proceedings]. (1979) (2)
The effects of refilling of the sarcoplasmic reticulum with Ca on [Ca2+]i in isolated rat ventricular myocytes (1990) (2)
Comparison of “Near Membrane” and Bulk Cytoplasmic Calcium Concentration in Single Cardiac Ventricular Myocytes During Spontaneous Calcium Waves (1996) (1)
Inhibition of SR Ca 2+ uptake increases Ca 2+ efflux generated by propagating waves of Ca 2+ release in isolated rat ventricular myocytes (2003) (1)
Kinetic Evidence in Favor of a Consecutive Model of the Sodium Pump (1983) (1)
Calcium Signaling in Cardiac Muscle (2010) (1)
Sydney Ringer viewed in a new light. (1994) (1)
The effects of metabolic inhibition on intracellular pH and Ca (1989) (1)
Is high Ryanodine receptor open probability arrhythmogenic (2006) (1)
2020: An unusual year (2021) (1)
218 Action Potential Alternans in the Ageing Ovine Atria (2014) (1)
Ryanodine receptors and cardiac function (2007) (1)
Na-Ca exchange in cardiac muscle (1990) (1)
Heart Failure and the Ryanodine Receptor (2002) (1)
A Practical Introduction to the Use of Intracellular Fluorescent Indicators (1991) (1)
Effects of phosphodiesterase-5 inhibition with sildenafil on calcium waves in cardiac myocytes (2017) (1)
198 Heart failure increases mitochondrial s-nitrosylation (2017) (1)
Does the adenosine A2A receptor stimulate the ryanodine receptor? (2007) (1)
Sarcoplasmic reticulum calcium fluctuation: the key to systolic calcium transient alternans? (2003) (1)
Measurement of intracellular calcium during the development and spontaneous relaxation of tonic tension in sheep cardiac Purkinje fibres (1986) (1)
Ca2+ Wave Development in Ventricular Cardiomyocytes from Mice with Inducible Knockout of SERCA2 (2009) (1)
Electro‐physics‐iology clarified? No spooky action required (2019) (1)
182 Circulation Research July 7 , 2017 Structural Considerations : The Dyad (2017) (0)
Effect of PKA dependent phosphorylation on Ca homeostasis in the aged heart (2006) (0)
Does the system reward scientific fraudsters? Does the system discourage reproducibility? (2020) (0)
Tetracaine abolishes arrhythmogenic while preserving inotropic effects of catecholamines (2002) (0)
Frequency-dependent changes in sarcoplasmic reticulum Ca 2+ content and Ca 2+ transients in rat ventricular myocytes under physiological conditions (2003) (0)
First steps (2020) (0)
Climbing aboard (2019) (0)
The road to IUPS (2013) (0)
Principles of Electropharmacology (2012) (0)
Edward Carmeliet: his contributions and scientific legacy (2021) (0)
IUPS 2017: The Rhythms of Life (2018) (0)
Positive aspects of negative data (2022) (0)
May 2013 sees the celebration of the 80th Birthday of Lionel Opie, founder of the Journal of Molecular and Cellular Cardiology. (2013) (0)
President’s View: Ensuring physiology flourishes (2018) (0)
Q&A: David Eisner, IUPS (2012) (0)
Physiology 2015: What I am most looking forward to: Ahead of The Society’s annual conference in Cardiff, Physiology 2015, Sarah Bundock asks The Society’s members for their personal highlights. (2015) (0)
The new team at JMCC (2008) (0)
JMCC Early Career Authors Prize (2008) (0)
The Cranefield Awards (2021) (0)
New President and CEO (2017) (0)
The best of times (2018) (0)
Student attitudes toward treating AIDS patients. (1989) (0)
Decision letter: A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice (2018) (0)
Chair's introduction (2008) (0)
Physiology in Europe: The role of FEPS now and in the near future: The benefits of coming together are plain to see. So just what is the problem in having a pan-European meeting? (2013) (0)
JGP in 2023. (2023) (0)
2022 (2022) (0)
Point/counterpoint: a new feature in the JMCC. (2008) (0)
The Cranefield Awards 2022. (2023) (0)
The GL Brown Lecture 2014 (2014) (0)
International Relations (2003) (0)
President’s View: Committing to inclusivity (2018) (0)
A transcriptomic insight into the mechanism underlying the decrease in atrial ICa-L in heart failure (2022) (0)
Grant policy (1993) (0)
The control of calcium release from the cardiac SR (2004) (0)
Alterations in the autonomic control of heart rate and heart rate variability in an ovine model of heart failure (2010) (0)
The effect of salicylate on Purkinje fibre pace-maker activity [proceedings]. (1977) (0)
PO-614-03 ALTERED SUBCELLULAR CALCIUM RELEASE IN THE HEART FAILURE ATRIA (2022) (0)
Changes in calcium homeostasis caused by a cardiotoxic drug (2012) (0)
Susceptibility to atrial alternans; a role for transverse (t)-tubule loss in heart failure (HF)? (2018) (0)
The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes (2014) (0)
Calcium signals mediated by IP 3 -gated channels in endothelial cells in pre-capillary arterioles (2006) (0)
The control of calcium signaling in the heart (2013) (0)
Controversies in PCI : DES vs. CABG for Left Main Disease(Special Lecture 7,The 73rd Annual Scientific Meeting of The Japanese Circulation Society) (2009) (0)
2- and 3-dimentional imaging of ureteric precapillary pericytes: morphology, Ca 2+ signalling and function (2009) (0)
Postnatal development of t-tubules and alterations in triggered calcium release in the sheep atria (2018) (0)
Editorial overview: Cardiac physiology from inside to out (2018) (0)
Intracellular Ca 2+ stores play a major role in Ca 2+ signalling in endothelial and smooth muscle cells of pre-capillary arterioles and are resistant to removal of external Ca 2+ (2007) (0)
A novel method for absolute measurement of intracellular pH applicable to any pH indicator (1988) (0)
Transmural gradients in excitation-contraction coupling in ventricular myocytes isolated from aged failing hearts (2012) (0)
Endothelial-dependent relaxation in the murine thoracic aorta is transiently increased after high fat feeding. (2013) (0)
Simultaneous Measurement of Cytoplasmic and SR Calcium during Modulation of Ryanodine Receptor Open Probability in Dog Ventricular Myocytes (2013) (0)
Phosphodiesterase-5 inhibition with sildenafil suppresses triggered ventricular arrhythmias and calcium waves via reduced sarcoplasmic reticulum content in the large mammal (2018) (0)
Bringing European physiologists together (2018) (0)
Postnatal development of t-tubules in ovine cardiac muscle (2014) (0)
Abstract 17013: Transverse (T)-tubules Are Widespread in the Human Atrium (2011) (0)
Amphiphysin II (Bin 1) driven transverse tubule formation in cardiac muscle. (2018) (0)
ALTERATIONS TO CARDIAC EXCITATION CONTRACTION COUPLING IN RESPONSE TO LONG- TERM CHANGES IN PHOTOPERIOD (2005) (0)
Metabolic inhibition increases alternans susceptibility in cardiac myocytes. (2010) (0)
Modulation of ryanodine receptor open probability has no maintained effect on the amplitude of systolic calcium release in sheep or dog ventricular myocytes (2012) (0)
PDE5 inhibition reduces ICa-L and systolic calcium transient in the failing sheep ventricle (2013) (0)
Proceedings of the Physiological Society, 16‐17 July 1982, Cambridge Meeting: Communications (2005) (0)
Phosphodiesterase 5 inhibition improves contractility and sympathetic sensitivity in the failing sheep myocardium (2016) (0)
Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure (2019) (0)
Proceedings of the Physiological Society, 22‐23 July 1988, Cambridge Meeting: Poster Communications (0)
The influence of ageing on intracellular calcium homeostasis in sheep atrial myocytes (2008) (0)
Propagation of calcium waves between paired ventricular myocytes from rat (2010) (0)
Effect of adrenaline on the potassium current reversal potential in cardiac Purkinje fibres of the sheep [proceedings]. (1977) (0)
Calcium signaling in heart: multiscale, diverse, rapid, local, and remarkable. (2013) (0)
IL-2 Integrative analysis of systolic Ca handling (2002) (0)
Investigating the Effects of a Cardiotoxic Drug on Calcium Homeostasis in the Heart (2013) (0)
Specific changes to intracellular Calcium homeostasis in heart failure result in an Atrial fibrillation-like phenotype in atrial myocytes. (2010) (0)
Effects of hydrogen peroxide on calcium handling in rat ventricular myocytes (2008) (0)
Stability and Instability of Ca 2+ Release from the SR (2005) (0)
2-D and 3-D imaging of microvascular network in situ - evidence for distinct mechanisms controlling Ca signalling in smooth muscle cells and pericytes of precapillary arterioles and postcapillary venules (2011) (0)
Hydrogen peroxide and sarcoplasmic reticulum dysfunction in rat ventricular myocytes (2010) (0)
General (1979) (0)
Beta adrenergic stimulation increases the sarcoplasmic reticulum threshold for arrhythmogenic diastolic calcium release in rat ventricular myocytes (2008) (0)
Alternans of systolic [Ca 2+ ] i and action potential duration in ventricular myocytes from failing sheep hearts (2008) (0)
Protein S-nitrosylation inhibits respiration in the failing heart (2018) (0)
Role of Nitric Oxide in the control of the SR Ca2+ release in myocytes of arteriolar networks in situ (2013) (0)
179 Phosphodiesterase-5 inhibition with sildenafil suppresses calcium waves by reducing sarcoplasmic reticulum content (2017) (0)
Functional significance of atrial t-tubules: effects of heart failure (2013) (0)
Proceedings of the Physiological Society, 30‐31 March 1990,University College London Meeting: Demonstrations (2005) (0)
Direct, simultaneous measurements of free intra-SR and cytosolic Ca2+ during Ca2+ waves (2012) (0)
The cardiac sarcoplasmic reticulum: relation to contraction and arrhythmias (2002) (0)
Calcium signalling and vasomotion in pre-capillary arterioles differs from that in arteries (2006) (0)
Impaired β-adrenergic responsiveness of failing ventricular myocytes from an ovine myocardial infarction-induced heart failure model (2022) (0)
Changes of SERCA Activity have Proportionately Smaller Effects on Sarcoplasmic Reticulum Calcium Content (2011) (0)
How does ageing modulate intracellular Ca homeostasis in the sheep atria (2011) (0)
MATHEMATICAL MODELLING OF ALTERNANS OF CALCIUM IN CARDIAC CELLS (2004) (0)
Selective Inhibition of Arrhythmogenic but Not Inotropic Effects of Ca Loading in Cardiac Muscle (2002) (0)
Altered cardiac EC coupling and ??-adrenergic responsiveness in an ovine model of heart failure. (2010) (0)
Disordered yet functional atrial t-tubules on recovery from heart failure (2021) (0)
Dual antiarrhythmic properties of phosphodiesterase-5 inhibitors suppress Ca2+ waves in systolic heart failure (2019) (0)
SERCA Inhibition Decreases the L Type Ca Current in Cardiac Muscle (2005) (0)
The regulation of contraction in cardiac muscle (1982) (0)
Intracellular pH Is Insensitive to Changes in Intracellular Calcium Concentration in Isolated Rat Ventricular Myocytes a (1996) (0)
Does transverse tubule formation and maintenance depend on the presence of amphiphysinII (2012) (0)
Na-Ca exchange effects on excitation and contraction (1990) (0)
CAMKII modulates cardiac excitation contraction coupling at multiple sites in ovine cardiac myocytes (2006) (0)
Development an ovine myocardial infarction- induced heart failure model and characterisation of altered calcium homeostasis mechanisms (2021) (0)
Increased sarcoplasmic reticulum diastolic calcium leak can produce biphasic decay of the cardiac systolic calcium transient (2013) (0)
Therole ofthesarcolemmal Ca2+-ATPase inthepHtransients associated withcontraction inratsmoothmuscle (2011) (0)
171 Amphiphysin ii (bin1) driven transverse tubule formation in cardiac muscle (2017) (0)
Ageing produces a distinct molecular fingerprint in the failing ovine ventricular myocardium (2011) (0)
Stability of the Intracellular Ca Transient and Alternans(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society) (2009) (0)
AmphiphysinII controls t-tubule formation in cardiac muscle (2013) (0)
Levick’s Introduction to Cardiovascular Physiology: A favourite cardiovascular textbook gets better (2019) (0)
Enhanced calcium release at specialised surface sites compensates for reduced t-tubule density in neonatal sheep atrial myocytes. (2022) (0)
Heart & Cardiac Muscle / Smooth Muscle (2005) (0)
The Interval‐Force Relationship of the Heart. Edited by M. I. M. Noble and W. A. Seed. Pp. 368. Cambridge University Press, 1992. £70.00 hardback. ISBN 0 521 40022 8 (1993) (0)
PO-614-04 STABILIZING CARDIAC RYANODINE RECEPTOR WITH DANTROLENE PREVENTS BINGE ALCOHOL AND CAFFEINE INDUCED VENTRICULAR TACHYARRHYTHMIAS (2022) (0)
Obituary: Stephen O’Neill (1963–2012) (2013) (0)
Changes of action potential duration and intracellular calcium following a change of pacing frequency in sheep ventricular myocytes (2011) (0)
Postnatal Development of T-Tubules in Sheep Atrial Myocytes (2016) (0)
Effects of heart failure on phosphodiesterase expression in the sheep ventricle (2012) (0)
S2-1 Tetracaine abolishes spontaneous but increases stimulated SR Ca release (2002) (0)
Increased alternans susceptibility in heart failure is linked to action potential morphology (2020) (0)
Measurement of intracellular sodium following a change of pacing frequency in sheep ventricular myocytes (2012) (0)
Regulation of Ion Channels and Intracellular Calcium in Cardiac and Smooth Muscle (1999) (0)
Production of local contractions in isolated rat ventricular myocytes (1990) (0)
Policy Focus: Interdisciplinary working and the Research Excellence Framework (REF): How can we recognise and reward research collaboration? (2021) (0)
Distinct structure and pharmacological properties of the precapillary sphincters in ureteric microvasculature. In situ imaging study. (2008) (0)
Reducing Ryanodine Receptor Open Probability as a Means to Abolish Spontaneous Ca 2 (cid:1) Release and Increase Ca 2 (cid:1) Transient Amplitude in Adult Ventricular Myocytes (2006) (0)
Effect of reduction in ryanodine receptor calcium leak on arrhythmogenesis in rat ventricular myocytes (2014) (0)

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