David F. Clayton
Researcher
David F. Clayton's AcademicInfluence.com Rankings

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Computer Science
David F. Clayton's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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Why Is David F. Clayton Influential?
(Suggest an Edit or Addition)According to Wikipedia, David Forrest Clayton is an American neuroscientist, biochemist, and academic. He is professor and the chair of the Department of Genetics & Biochemistry at Clemson University. Clayton is most known for his work on the interplay between the brain and the genome in regulating cognitive processes involved in the filtering, encoding, and retrieval of memories. He pioneered the application of molecular genetics to research using songbirds as a model for learning, memory, and brain development leading to whole genome sequencing of the zebra finch in 2010. His research has contributed to topics ranging from neurodegenerative disease to social behavior and he coined the term “Genomic action potential” to describe the complex, structured genomic response to acute experience. His research has been featured in newspapers including BBC News, The Wall Street Journal, and Newsweek.
David F. Clayton's Published Works
Published Works
- Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes* (1998) (1476)
- Habituation revisited: An updated and revised description of the behavioral characteristics of habituation (2009) (1180)
- Characterization of a novel protein regulated during the critical period for song learning in the zebra finch (1995) (837)
- The genome of a songbird (2010) (834)
- The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease (1998) (765)
- Song presentation induces gene expression in the songbird forebrain. (1992) (628)
- Towards complete and error-free genome assemblies of all vertebrate species (2020) (557)
- Genes and Social Behavior (2008) (495)
- Synucleins in synaptic plasticity and neurodegenerative disorders (1999) (439)
- Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinson's Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity (1998) (399)
- The Genomic Action Potential (2000) (383)
- Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. (2000) (376)
- Dosage compensation is less effective in birds than in mammals (2007) (316)
- Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes (1983) (298)
- Repeated exposure to one song leads to a rapid and persistent decline in an immediate early gene's response to that song in zebra finch telencephalon (1995) (297)
- Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins* (2001) (264)
- Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. (1997) (231)
- Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System (1996) (217)
- Estrogen synthesis in the male brain triggers development of the avian song control pathway in vitro (2001) (216)
- Functional identification of sensory mechanisms required for developmental song learning (2008) (211)
- Dependence of liver-specific transcription on tissue organization (1985) (210)
- Response Modulation in the Zebra Finch Neostriatum: Relationship to Nuclear Gene Regulation (1997) (210)
- Localized Changes in Immediate-Early Gene Regulation during Sensory and Motor Learning in Zebra Finches (1997) (163)
- Development of song responses in the zebra finch caudomedial neostriatum: role of genomic and electrophysiological activities. (2001) (142)
- The Songbird Neurogenomics (SoNG) Initiative: Community-based tools and strategies for study of brain gene function and evolution (2008) (138)
- Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences. (1987) (135)
- Posttranscriptional modulation of gene expression in cultured rat hepatocytes (1984) (131)
- Molecular evolution of genes in avian genomes (2010) (123)
- Dynamic Role of Postsynaptic Caspase-3 and BIRC4 in Zebra Finch Song-Response Habituation (2006) (123)
- Correspondence between sites of NGFI-A induction and sites of morphological plasticity following exposure to environmental complexity. (1995) (119)
- Sex bias and dosage compensation in the zebra finch versus chicken genomes: general and specialized patterns among birds. (2010) (102)
- Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells. (2001) (93)
- Role of gene regulation in song circuit development and song learning. (1997) (93)
- Birdsong “Transcriptomics”: Neurochemical Specializations of the Oscine Song System (2008) (92)
- Context-specific habituation of the zenk gene response to song in adult zebra finches (2004) (90)
- Seasonal Differences of Gene Expression Profiles in Song Sparrow (Melospiza melodia) Hypothalamus in Relation to Territorial Aggression (2009) (88)
- Discrete molecular states in the brain accompany changing responses to a vocal signal (2009) (86)
- Liver-specific RNA metabolism in hepatoma cells: variations in transcription rates and mRNA levels (1985) (85)
- Habituation in songbirds (2009) (80)
- Differential induction of the ZENK gene in the avian forebrain and song control circuit after metrazole-induced depolarization. (1995) (74)
- Activation and Habituation of Extracellular Signal-Regulated Kinase Phosphorylation in Zebra Finch Auditory Forebrain during Song Presentation (2004) (73)
- Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids (2000) (72)
- Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression (1986) (70)
- The canary androgen receptor mRNA is localized in the song control nuclei of the brain and is rapidly regulated by testosterone. (1995) (69)
- Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes (2009) (68)
- Seasonal and tissue-specific regulation of canary androgen receptor messenger ribonucleic acid. (1994) (64)
- Integrating Genomes, Brain and Behavior in the Study of Songbirds (2009) (62)
- Impact of experience-dependent and -independent factors on gene expression in songbird brain (2012) (61)
- Song exposure regulates known and novel microRNAs in the zebra finch auditory forebrain (2011) (59)
- Immediate-early gene responses in the avian song control system: cloning and expression analysis of the canary c-jun cDNA. (1994) (58)
- Natural selection in avian protein‐coding genes expressed in brain (2008) (56)
- Rapidly learned song-discrimination without behavioral reinforcement in adult male zebra finches (Taeniopygia guttata) (2003) (54)
- Probes for rare mRNAs reveal distributed cell subsets in canary brain (1988) (51)
- Minimal Experience Required for Immediate-Early Gene Induction in Zebra Finch Neostriatum (2000) (50)
- Developmental shifts in gene expression in the auditory forebrain during the sensitive period for song learning (2009) (50)
- Seasonal Changes in Patterns of Gene Expression in Avian Song Control Brain Regions (2012) (49)
- Variation in reproductive success across captive populations: Methodological differences, potential biases and opportunities (2017) (49)
- The zebra finch neuropeptidome: prediction, detection and expression (2010) (46)
- The genomics of memory and learning in songbirds. (2013) (45)
- A cDNA microarray from the telencephalon of juvenile male and female zebra finches (2004) (44)
- Partial dissociation of molecular and behavioral measures of song habituation in adult zebra finches (2008) (40)
- Influence of restraint and acute isolation on the selectivity of the adult zebra finch zenk gene response to acoustic stimuli (2002) (39)
- Acoustic event detection for multiple overlapping similar sources (2015) (39)
- Brain transcriptome sequencing and assembly of three songbird model systems for the study of social behavior (2014) (38)
- The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential (2019) (38)
- Synelfin Regulation during the Critical Period for Song Learning in Normal and Isolated Juvenile Zebra Finches (1997) (37)
- In situ hybridization using PEG-embedded tissue and riboprobes: increased cellular detail coupled with high sensitivity. (1989) (36)
- Lipid imaging in the zebra finch brain with secondary ion mass spectrometry (2007) (33)
- Songbird Genomics: Methods, Mechanisms, Opportunities, and Pitfalls (2004) (33)
- Reptiles and Mammals Have Differentially Retained Long Conserved Noncoding Sequences from the Amniote Ancestor (2010) (31)
- TECHNICAL ADVANCES: A microarray for large‐scale genomic and transcriptional analyses of the zebra finch (Taeniopygia guttata) and other passerines (2008) (30)
- Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch (2010) (29)
- Differential regulation in the avian song control circuit of an mRNA predicting a highly conserved protein related to protein kinase C and the bcr oncogene. (1992) (28)
- Small molecule analysis and imaging of fatty acids in the zebra finch song system using time‐of‐flight‐secondary ion mass spectrometry (2011) (25)
- New Frontiers for Organismal Biology (2013) (25)
- RNA-seq transcriptome analysis of male and female zebra finch cell lines. (2012) (24)
- High throughput analysis reveals dissociable gene expression profiles in two independent neural systems involved in the regulation of social behavior (2012) (23)
- Testosterone regulates α-synuclein mRNA in the avian song system (2001) (21)
- Detailed temporal structure of communication networks in groups of songbirds (2016) (19)
- Expression of fragile X mental retardation protein within the vocal control system of developing and adult male zebra finches (2008) (19)
- The Zebra Finch genome and avian genomics in the wild (2010) (18)
- Acute social isolation alters neurogenomic state in songbird forebrain (2019) (18)
- Brain transcriptome of the violet-eared waxbill Uraeginthus granatina and recent evolution in the songbird genome (2013) (16)
- Conservation and expression of IQ‐domain‐containing calpacitin gene products (neuromodulin/GAP‐43, neurogranin/RC3) in the adult and developing oscine song control system (2009) (16)
- Functional genomic analysis and neuroanatomical localization of miR-2954, a song-responsive sex-linked microRNA in the zebra finch (2014) (16)
- Proteomic analyses of zebra finch optic tectum and comparative histochemistry. (2007) (14)
- The opportunities and challenges of large-scale molecular approaches to songbird neurobiology (2015) (14)
- Transcript‐ and annotation‐guided genome assembly of the European starling (2021) (13)
- Oxytocin , Vasopressin , and the Neurogenetics of Sociality (2008) (13)
- Acoustic developmental programming: a mechanistic and evolutionary framework. (2021) (12)
- Forebrain-enriched RNAs of the canary: a population analysis using hybridization kinetics. (1990) (12)
- Structure and expression of canary myc family genes (1991) (11)
- The neurobiology of Zebra Finch song: insights from gene expression studies (2010) (11)
- Proteomic analyses of songbird (Zebra finch; Taeniopygia guttata) retina. (2007) (10)
- Advancing avian behavioral neuroendocrinology through genomics (2014) (9)
- The neural basis of avian song learning and perception (2000) (9)
- Testosterone regulates alpha-synuclein mRNA in the avian song system. (2001) (9)
- Concurrent invasions by European starlings (Sturnus vulgaris) suggest selection on shared genomic regions even after genetic bottlenecks (2021) (7)
- The variability of song variability in zebra finch (Taeniopygia guttata) populations (2019) (5)
- Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds (2019) (4)
- Molecular Neurobiology of Bird Song (2007) (4)
- Noninvasive diffusive optical imaging of the auditory response to birdsong in the zebra finch (2013) (3)
- Learning birdsong by imitation (2019) (3)
- Serotonin Expression in the Song Circuitry of Adult Male Zebra Finches (2020) (2)
- The Non-Amyloid-β Component of Alzheimer’s Disease Plaque Amyloid: Comparative Analysis Suggests a Normal Function as a Synaptic Plasticizer (1996) (2)
- The variability of song variability in wild and domesticated zebra finches Taeniopygia guttata (2018) (2)
- Erratum to “A cDNA microarray from the telencephalon of juvenile male and female zebra finches”: [J. Neurosci. Methods 138 (2004) 199–206] (2005) (1)
- High throughput analysis reveals dissociable gene expression profiles in two independent neural systems involved in the regulation of social behavior (2012) (1)
- A Memoir on Memory (2002) (1)
- Acknowledgment of Guest Editors, 2019 (2019) (1)
- Transcriptional Control of β-Globin and Liver-Specific Genes in Mouse Cells (1984) (1)
- Bird song comparison using deep learning trained from avian perceptual judgments (2022) (1)
- Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds (2019) (0)
- Synelfin mRNA Expression is Differentially Regulated in Nucleus IMAN of Zebra Finches Raised Under Acoustic Isolation (1995) (0)
- Erratum to “A cDNA microarray from the telencephalon of juvenile male and female zebra finches” [J. Neurosci. Methods 138 (2004) 199–206] (2005) (0)
- Researchevolution of genes in avian genomes (2010) (0)
- high sensitivity. In situ hybridization using PEG-embedded tissue and riboprobes: increased cellular detail coupled with (2011) (0)
- New Frontiers for Organismal Biology The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2014) (0)
- α-SYNUCLEIN IMMUNOREACTIVITY IN LEWY BODIES AND ABNORMAL NEURITES IN PARKINSONʼS DISEASE AND DEMENTIA WITH LEWY BODY BRAIN (1998) (0)
- Noninvasive diffusive optical imaging of the auditory response to birdsong in the zebra finch (2013) (0)
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