David A. Fidock
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Australian microbiologist
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David A. Fidock's Degrees
- PhD Microbiology University of Melbourne
- Bachelors Microbiology University of Melbourne
Why Is David A. Fidock Influential?
(Suggest an Edit or Addition)According to Wikipedia, David A. Fidock , is the CS Hamish Young Professor of Microbiology and Immunology and Professor of Medical Sciences at Columbia University Irving Medical Center in Manhattan. Education and Training David Fidock was born in Paris, on 8 December 1965 and moved to Australia when he was seven years old. He attended the University of Adelaide and earned a bachelor of mathematical sciences and an honors degree in genetics in 1985. He earned a PhD in Microbiology with a focus on malaria in 1994, with his thesis Molecular and Immuno-Epidemiological Studies of the Plasmodium falciparum STARP and LSA-1 Antigens Expressed During the Pre-Erythrocytic Stages in Humans, advised by Dr. Pierre Druilhe. He then received a post-graduate diploma in Medical Entomology from the Institut Pasteur in Paris in 1994. Following his graduation, he pursued his post-doctoral training in malaria research at the University of California Irvine from 1995-96. He then continued his post-doctoral training at the National Institutes of Allergy an Infectious Diseases with Dr. Thomas Wellems.
David A. Fidock's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. (2000) (1353)
- Spiroindolones, a Potent Compound Class for the Treatment of Malaria (2010) (983)
- Antimalarial drug discovery: efficacy models for compound screening (2004) (868)
- Malaria: progress, perils, and prospects for eradication. (2008) (730)
- Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations (2002) (728)
- K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates (2015) (533)
- Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. (1997) (507)
- A molecular marker for chloroquine-resistant falciparum malaria. (2001) (492)
- Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria (2009) (458)
- A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms. (2016) (433)
- Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. (2006) (397)
- pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum (2005) (379)
- Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016) (324)
- Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic (2017) (323)
- Targeting Plasmodium PI(4)K to eliminate malaria (2013) (322)
- A novel multiple-stage antimalarial agent that inhibits protein synthesis (2015) (315)
- Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda (2020) (314)
- Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery (2011) (307)
- The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. (2008) (288)
- Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue (2011) (288)
- A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (2015) (273)
- Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. (2002) (265)
- A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study (2017) (259)
- Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance (2015) (248)
- Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase (2003) (247)
- Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase (2006) (241)
- Artemisinin Action and Resistance in Plasmodium falciparum. (2016) (238)
- PfCRT and its role in antimalarial drug resistance. (2012) (233)
- In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa. (2009) (211)
- Transporters involved in resistance to antimalarial drugs. (2006) (205)
- A critical role for PfCRT K76T in Plasmodium falciparum verapamil‐reversible chloroquine resistance (2005) (203)
- Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase* (2002) (201)
- (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (2014) (200)
- Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies (2016) (193)
- Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. (2004) (189)
- Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance (2005) (187)
- Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria. (2001) (184)
- Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America (2001) (184)
- Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families (2013) (178)
- Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase (2017) (174)
- Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase. (1998) (171)
- Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites§ (2007) (165)
- Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases (2012) (162)
- Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics (2017) (161)
- Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum (2006) (154)
- In Vitro Efficacy, Resistance Selection, and Structural Modeling Studies Implicate the Malarial Parasite Apicoplast as the Target of Azithromycin* (2007) (154)
- Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine (2018) (152)
- Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria (1995) (147)
- Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. (1994) (138)
- Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets (2011) (137)
- Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum (2009) (135)
- Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum (2011) (134)
- Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH. (2004) (132)
- Genetic Disruption of the Plasmodium falciparum Digestive Vacuole Plasmepsins Demonstrates Their Functional Redundancy* (2004) (124)
- Chloroquine Resistance Modulated in Vitro by Expression Levels of the Plasmodium falciparum Chloroquine Resistance Transporter* (2003) (123)
- Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. (2009) (122)
- Type II Fatty Acid Biosynthesis Is Essential for Plasmodium falciparum Sporozoite Development in the Midgut of Anopheles Mosquitoes (2013) (120)
- Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum. (2015) (120)
- KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission (2014) (119)
- Disruption of Plasmodium falciparumChitinase Markedly Impairs Parasite Invasion of Mosquito Midgut (2001) (115)
- Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites (2011) (114)
- Drug discovery: Priming the antimalarial pipeline (2010) (112)
- Advances in understanding the genetic basis of antimalarial drug resistance. (2007) (111)
- Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption (2000) (108)
- Recent highlights in antimalarial drug resistance and chemotherapy research. (2008) (107)
- Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. (2005) (107)
- Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay (2013) (106)
- Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum (2010) (105)
- The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences. (1999) (105)
- Supergenomic Network Compression and the Discovery of EXP1 as a Glutathione Transferase Inhibited by Artesunate (2014) (103)
- PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX (2006) (97)
- The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome. (2000) (96)
- Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum. (2000) (95)
- UDP-galactose and Acetyl-CoA transporters as Plasmodium multidrug resistance genes (2016) (95)
- In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes. (2008) (94)
- A broad analysis of resistance development in the malaria parasite (2016) (94)
- Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt (2015) (93)
- Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity (2017) (90)
- Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro (2017) (89)
- A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine (2017) (88)
- Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT (2019) (88)
- DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparum (2014) (87)
- A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue (2017) (86)
- Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. (2009) (84)
- Identifying apicoplast‐targeting antimalarials using high‐throughput compatible approaches (2011) (84)
- Open-source discovery of chemical leads for next-generation chemoprotective antimalarials (2018) (83)
- UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria (2018) (80)
- Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance (2020) (78)
- Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors (2009) (78)
- Cloning and characterization of a novel Plasmodium falciparum sporozoite surface antigen, STARP. (1994) (77)
- Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study (2017) (77)
- Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages (2018) (77)
- Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis. (2005) (75)
- Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study (2018) (75)
- Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum (2013) (74)
- Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria. (2020) (73)
- Investigations into the Role of the Plasmodium falciparum SERCA (PfATP6) L263E Mutation in Artemisinin Action and Resistance (2010) (69)
- Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. (2006) (66)
- Plasmodium falciparum sporozoite invasion is inhibited by naturally acquired or experimentally induced polyclonal antibodies to the STARP antigen (1997) (65)
- Differences in trans‐stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum (2007) (65)
- Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum. (2019) (65)
- Using genetic methods to define the targets of compounds with antimalarial activity. (2013) (64)
- Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission (2013) (63)
- Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum (2009) (63)
- Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria (2013) (62)
- X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy* (2007) (62)
- Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities (2015) (62)
- Malaria's Missing Number: Calculating the Human Component of R0 by a Within-Host Mechanistic Model of Plasmodium falciparum Infection and Transmission (2013) (60)
- Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum. (2007) (60)
- Multicolor Bioluminescence Boosts Malaria Research: Quantitative Dual-Color Assay and Single-Cell Imaging in Plasmodium falciparum Parasites (2014) (59)
- How can we identify parasite genes that underlie antimalarial drug resistance? (2011) (59)
- A method for rapid genetic integration into Plasmodium falciparum utilizing mycobacteriophage Bxb1 integrase. (2010) (55)
- CRISPR‐Cas9‐modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based combination therapy partner drugs (2016) (54)
- Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes (2016) (52)
- Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum (2016) (51)
- Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc1 Complex of Plasmodium falciparum (2015) (50)
- Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness (2021) (50)
- Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. (2006) (50)
- Disruption of the C-terminal region of EBA-175 in the Dd2/Nm clone of Plasmodium falciparum does not affect erythrocyte invasion. (2000) (50)
- Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling (2016) (49)
- Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival (2021) (48)
- Transfusion of stored blood impairs host defenses against Gram‐negative pathogens in mice (2014) (48)
- Modeling Within-Host Effects of Drugs on Plasmodium falciparum Transmission and Prospects for Malaria Elimination (2014) (47)
- Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif (2008) (47)
- Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter (2015) (46)
- Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria (2011) (46)
- A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (2017) (46)
- Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery (2019) (46)
- Comparative 3D genome organization in apicomplexan parasites (2019) (45)
- Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity (2020) (45)
- Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum. (2001) (44)
- Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13 (2020) (44)
- Parasite‐induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection (2015) (44)
- In Vivo and In Vitro Antimalarial Properties of Azithromycin-Chloroquine Combinations That Include the Resistance Reversal Agent Amlodipine (2011) (43)
- Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate (2015) (43)
- Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening. (2007) (43)
- The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 Modulates In Vitro Parasite Response to Artemisinin and Quinine (2015) (42)
- Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology (2016) (42)
- Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents (2019) (41)
- Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model (2018) (41)
- Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum. (2008) (41)
- Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria (2020) (41)
- Degrees of chloroquine resistance in Plasmodium - is the redox system involved? (2012) (39)
- Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants (2021) (38)
- Origin of robustness in generating drug-resistant malaria parasites. (2014) (38)
- Eliminating Malaria (2013) (38)
- Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors. (2018) (38)
- MalDA, Accelerating Malaria Drug Discovery (2021) (36)
- Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target (2009) (36)
- Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes. (2011) (35)
- Protein Degradation Systems as Antimalarial Therapeutic Targets. (2017) (35)
- Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage (2014) (35)
- Vesicular ATPase-overexpressing Cells Determine the Distribution of Malaria Parasite Oocysts on the Midguts of Mosquitoes* (1999) (35)
- The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites (2019) (34)
- Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials. (2021) (34)
- N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds. (2014) (34)
- Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites (2016) (34)
- A key role for lipoic acid synthesis during Plasmodium liver stage development (2013) (33)
- Plasmodium falciparum resistance to piperaquine driven by PfCRT. (2019) (33)
- CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites (2014) (33)
- Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. (2014) (32)
- Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. (2006) (30)
- Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness (2019) (30)
- Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity (2017) (30)
- P. falciparum CG2, Linked to Chloroquine Resistance, Does Not Resemble Na+/H+ Exchangers (1998) (29)
- A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase‐based mature gametocyte assay (2017) (29)
- Identification of a role for the PfEMP1 semi‐conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells (2010) (28)
- Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. (2018) (27)
- Editing the Plasmodium vivax genome, using zinc-finger nucleases. (2015) (26)
- Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility (2020) (26)
- Stage-dependent Localization of a Novel Gene Product of the Malaria Parasite, Plasmodium falciparum * (2001) (24)
- The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites (2017) (24)
- Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter (2018) (24)
- Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites. (2015) (23)
- Molecular markers of Plasmodium resistance to antimalarials (2011) (23)
- Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia (2019) (22)
- Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes (2017) (22)
- Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase Year (2003) (22)
- First evidence of pfcrt mutant Plasmodium falciparum in Madagascar. (2006) (22)
- Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1 (2015) (22)
- In Vitro and In Vivo Activity of Solithromycin (CEM-101) against Plasmodium Species (2011) (21)
- Novel diaryl ureas with efficacy in a mouse model of malaria. (2013) (21)
- Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants (2021) (20)
- Triclosan is minimally effective in rodent malaria models (2011) (20)
- Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors (2019) (20)
- A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 (2020) (20)
- Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention (2021) (19)
- Loss of malarial susceptibility to artemisinin in Thailand (2012) (19)
- Differential Drug Efflux or Accumulation Does Not Explain Variation in the Chloroquine Response of Plasmodium falciparum Strains Expressing the Same Isoform of Mutant PfCRT (2011) (19)
- Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport (2020) (18)
- Nucleotide sequence of the F41 fimbriae subunit gene in Escherichia coli B41. (1989) (17)
- UV-triggered Affinity Capture Identifies Interactions between the Plasmodium falciparum Multidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells* (2013) (17)
- Mechanisms of Antimalarial Drug Action and Resistance (2005) (17)
- Conservation of the Plasmodium falciparum sporozoite surface protein gene, STARP, in field isolates and distinct species of Plasmodium. (1994) (17)
- An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum (2013) (17)
- Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor (2020) (16)
- Genome projects, genetic analysis, and the changing landscape of malaria research. (1999) (16)
- A ubiquitous Plasmodium protein displays a unique surface labeling pattern in sporozoites. (2006) (16)
- Plasmodium falciparum In Vitro Drug Resistance Selections and Gene Editing. (2019) (15)
- A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3' untranslated region and intronic cis-elements. (2009) (15)
- Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway (2019) (15)
- Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials (2020) (14)
- Erratum: (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E5455-E5462) 1 DOI: 10.1073/pnas.1414221111) (2015) (14)
- Artemisia annua L. hot-water extracts show potent activity in vitro against Covid-19 variants including delta (2021) (14)
- Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene. (2012) (13)
- Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model (2013) (13)
- Prioritization of Molecular Targets for Antimalarial Drug Discovery (2021) (13)
- Stable Integration and Comparison of hGrx1-roGFP2 and sfroGFP2 Redox Probes in the Malaria Parasite Plasmodium falciparum. (2018) (13)
- Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. (2021) (12)
- In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei (2011) (12)
- Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome (2021) (11)
- Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition (2020) (11)
- Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites (2021) (11)
- Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study (2021) (11)
- Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. (2013) (10)
- The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance (2021) (10)
- Mutations Conferring Drug Resistance in Malaria Parasite Drug Transporters Pgh1 and PfCRT Do Not Affect Steady-State Vacuolar Ca2+ (2005) (10)
- Perspectives: The missing pieces (2012) (10)
- Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters (2019) (10)
- Arresting malaria parasite egress from infected red blood cells. (2008) (10)
- Plasmodium falciparum: ribosomal P2 protein gene expression is independent of the developmentally regulated rRNAs. (1998) (10)
- Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. (2021) (9)
- Mechanisms of Quinoline Resistance (2001) (9)
- Erratum to "Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives" [Bioorg. Med. Chem. Lett. 15 (2005) 5247-5252] (DOI:10.1016/j.bmcl.2005.08.044) (2006) (9)
- The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance (2021) (9)
- Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis (2016) (8)
- Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1 (2016) (8)
- Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors (2021) (8)
- The Longin Domain Regulates the Steady-State Dynamics of Sec22 in Plasmodium falciparum (2009) (8)
- Plasmodium falciparum resistance to artemisinin-based combination therapies (2022) (8)
- Genetic screens reveal a central role for heme biosynthesis in artemisinin susceptibility (2019) (8)
- Artemisinin resistance in Africa: How urgent is the threat? (2021) (8)
- Taking Charge: Feeding Malaria via Anion Channels (2011) (8)
- Recent insights into fatty acid acquisition and metabolism in malarial parasites (2010) (7)
- Genetic Approaches to the Determinants of Drug Response, Pathogenesis and Infectivity in Plasmodium falciparum Malaria (1999) (7)
- Artemisia annua L. extracts prevent in vitro replication of SARS-CoV-2. (2021) (7)
- Signatures , and Molecular Targets Chemical Genomic Profiling for Antimalarial Therapies , Response (2011) (7)
- Antimalarial efficacy of MMV390048, an inhibitor of phosphatidylinositol 4-kinase. (2017) (7)
- Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone (2019) (7)
- Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology. (2021) (7)
- Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance (2021) (6)
- Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum? (2020) (6)
- Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone (2019) (6)
- Plasmodium falciparum: generation of a cDNA library enriched in sporozoite-specific transcripts by directional tag subtractive hybridization. (2000) (6)
- Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes (2021) (6)
- A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin (2022) (6)
- The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957 (2021) (5)
- The RTS,S vaccine—a chance to regain the upper hand against malaria? (2022) (5)
- Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance (2022) (5)
- The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages (2022) (4)
- Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study. (2022) (4)
- Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum (2022) (4)
- Blocking Plasmodium Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts (2019) (4)
- ML238: An Antimalarial Small Molecule of a Unique Structural Class (2011) (4)
- Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2 (2022) (4)
- Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (2021) (4)
- Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda (2021) (4)
- Production of stage-specific Plasmodium falciparum cDNA libraries using subtractive hybridization. (2002) (4)
- Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound (2020) (3)
- Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages (2018) (3)
- Drug discovery: Chemical diversity targets malaria (2016) (3)
- Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. (2021) (3)
- Expression of recombinant human plasminogen activator inhibitor type-2 (1989) (3)
- Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 (2022) (2)
- Construction of Plasmodium falciparum lambda cDNA libraries. (2002) (2)
- Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (2022) (2)
- Piperaquine Resistance is Associated with a Copy Number Variation on 1 (2011) (2)
- No Evidence of Decreased Artemisinin Efficacy in a High-Transmission Malaria Setting in Mali (2012) (2)
- Pyronaridine-Artesunate Shows Promise as an Effective and Well-Tolerated Treatment for Artemisinin-Resistant Plasmodium falciparum Malaria. (2019) (2)
- Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites (2021) (2)
- A Breathprint for Malaria: New Opportunities for Noninterventional Diagnostics and Mosquito Traps? (2018) (2)
- Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials (2022) (2)
- Construction of Plasmodium falciparum γ cDNA Libraries (2002) (2)
- Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing (2021) (2)
- Malaria parasite beats the heat (2021) (2)
- 3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum. (2021) (2)
- CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites (2014) (2)
- Erratum for Brunschwig et al., “UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria” (2018) (2)
- Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target (2023) (1)
- IDENTIFICATION OF THE PLASMODIUM FALCIPARUM ACETYL-COA SYNTHETASE AS AN EMERGING ANTIPLASMODIAL DRUG TARGET (2019) (1)
- Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages (2022) (1)
- Hemozoin Promotes Lung Inflammation via Host Epithelial Activation (2021) (1)
- IDENTIFYING HEXAHYDROQUINOLINES AS NEW ANTIMALARIALS WITH POTENT BLOOD STAGE AND TRANSMISSION-BLOCKING ACTIVITY (2017) (1)
- Author response: Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance (2020) (1)
- Evidence of Artemisinin-Resistant Malaria in Africa. (2022) (1)
- Keystone Malaria Symposium 2022: a vibrant discussion of progress made and challenges ahead from drug discovery to treatment. (2022) (0)
- Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine (2018) (0)
- Modelstant Malaria in a Rodent Effective Partner Drug for Treatment of Evidence for Pyronaridine as a Highly (2014) (0)
- Hemozoin directly induces inflammation and upregulation of CD36 in lung epithelium and endothelium (2017) (0)
- Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation (2023) (0)
- Preclinical Antimalarial Combination Studies: The Case of M5717, a P. falciparum 1 Elongation Factor 2 Inhibitor and Pyronaridine, a Hemozoin Formation Inhibitor (2020) (0)
- Integrative genetic manipulation of Plasmodium cynomolgi reveals MultiDrug Resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine. (2022) (0)
- Hemozoin Promotes Lung Injury Via Direct Host Epithelial Activation (2020) (0)
- Meister Antimalarial Drug Discovery Liver Stages to Drive Next-Generation Plasmodium Imaging of (2012) (0)
- Text S 1 – Supporting Information Modeling Within-Host Effects of Drugs on Transmission and Prospects for Malaria Elimination (2013) (0)
- Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. (2023) (0)
- P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites (2021) (0)
- Plasmodium falciparum artemisinin-resistant K13 mutations confer a sexual-stage transmission advantage that can be overcome with atovaquone-proguanil (2020) (0)
- INTRODUCTION 8 Mechanisms of Quinoline Resistance (0)
- Targeting Mitochondrial Metabolism as a Key Vulnerability in Artemisinin-Resistant Plasmodium falciparum Malaria (2020) (0)
- Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog (2003) (0)
- A candidate molecule for chloroquine resistance in Plasmodium falciparum malaria (1998) (0)
- An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum (2013) (0)
- Pan-active imidazolopiperazine antimalarials target the falciparum intracellular secretory pathway. (2020) (0)
- Malarial enoyl acyl ACP reductase bound with INH-NAD adduct (2007) (0)
- Identifying New Chemical Entities that Treat and Prevent Relapsing Vivax and Drug Resistant Falciparum Malaria in U.S. Military Personnel (2016) (0)
- Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages (2018) (0)
- Effects of Iron Status and Iron Supplementation on Salmonella Typhimurium and Plasmodium Yoelii Infection In Mice (2010) (0)
- Structural insights on three series of anti-malarial N-myristoyltransferase inhibitors (2018) (0)
- Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity (2017) (0)
- Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform (2019) (0)
- Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation (2016) (0)
- Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1 (2015) (0)
- Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. (2007) (0)
- Pearson correlation coefficient values for MitoTracker Deep Red imaging studies. (2020) (0)
- Eliminating Malaria MICROBIOLOGY (2014) (0)
- CRYSTAL STRUCTURE ANALYSIS OF PLASMODIUM FALCIPARUM ENOYL-ACYL-CARRIER-PROTEIN REDUCTASE WITH NADH (2003) (0)
- IDENTIFICATION OF A DUAL LIVER-ASEXUAL STAGE ANTIMALARIAL TARGETING PFDHODH (2018) (0)
- Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages (2020) (0)
- sporozoite development in the midgut of Anopheles mosquitoes 2 (2013) (0)
- Erratum: Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase (2006) (0)
- A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Chemoprophylactic Activity of M5717 Against Plasmodium Falciparum in a Controlled Human Malaria Infection (2022) (0)
- Oligonucleotides used in this study. (2020) (0)
- The Plasmodium falciparum protein PfMRP1 functions as an influx ABC transporter (2022) (0)
- Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4 (2023) (0)
- Triaminopyrimidines antimalarial agent NatComm 2015 (2015) (0)
- Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes (2017) (0)
- Correction for Jiménez-Díaz et al., (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (2015) (0)
- Structure and drug resistance of the Plasmodium falciparum transporter PfCRT (2019) (0)
- Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria (2020) (0)
- The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites (2017) (0)
- Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter (2018) (0)
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