David G. Clayton
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David G. Claytonbiology Degrees
Biology
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#18244
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Bioinformatics
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#190
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Genetics
#1653
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#1761
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Biology
David G. Clayton's Degrees
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)David G. Clayton's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (2007) (9208)
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease (2003) (2257)
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes (2007) (1471)
- Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants (2007) (1421)
- Haplotype tagging for the identification of common disease genes (2001) (1248)
- Genome-wide association studies: theoretical and practical concerns (2005) (1210)
- The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. (1996) (1094)
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes (2010) (952)
- Genetically distinct subsets within ANCA-associated vasculitis. (2012) (820)
- Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes (2009) (818)
- Complement C3 variant and the risk of age-related macular degeneration. (2007) (778)
- Seven New Loci Associated with Age-Related Macular Degeneration (2013) (741)
- A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. (1999) (668)
- A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region (2006) (660)
- Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC (1994) (632)
- Shared and distinct genetic variants in type 1 diabetes and celiac disease. (2008) (571)
- Population structure, differential bias and genomic control in a large-scale, case-control association study (2005) (570)
- Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A (2007) (548)
- Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. (2004) (537)
- Control of confounding of genetic associations in stratified populations. (2003) (505)
- Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation (1995) (490)
- Detecting Disease Associations due to Linkage Disequilibrium Using Haplotype Tags: A Class of Tests and the Determinants of Statistical Power (2003) (451)
- Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes (2007) (449)
- A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. (2002) (441)
- Genetic association studies (2005) (389)
- Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. (2005) (359)
- Linkage of the angiotensinogen gene to essential hypertension. (1994) (354)
- Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation (2005) (344)
- Design and analysis of admixture mapping studies. (2004) (306)
- A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk (2010) (290)
- Transmission/disequilibrium tests for extended marker haplotypes. (1999) (288)
- The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes (2009) (275)
- Quantification of homozygosity in consanguineous individuals with autosomal recessive disease. (2006) (272)
- Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes (2009) (249)
- Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene‐gene and gene‐environment interactions, and parent‐of‐origin effects (2004) (232)
- Remapping the insulin gene/IDDM2 locus in type 1 diabetes. (2004) (229)
- Age-adjusted recurrence risks for relatives of patients with multiple sclerosis. (1996) (223)
- A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes (2014) (222)
- Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey. (2000) (214)
- Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing (2009) (199)
- Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. (2004) (192)
- Use of unphased multilocus genotype data in indirect association studies (2004) (190)
- A robust statistical method for case-control association testing with copy number variation (2008) (189)
- Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. (2006) (182)
- Betting odds and genetic associations. (2004) (172)
- Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. (2002) (143)
- Testing for association on the X chromosome (2008) (137)
- Complement C 3 Variant and the Risk of Age-Related Macular Degeneration (2007) (136)
- Copy number, linkage disequilibrium and disease association in the FCGR locus (2010) (136)
- Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population. (1997) (136)
- Analysis of longitudinal studies with death and drop‐out: a case study (2004) (136)
- Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA‐B and HLA‐A (2009) (131)
- Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. (2000) (126)
- Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers. (1995) (116)
- An R Package for Analysis of Whole-Genome Association Studies (2007) (113)
- Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight (2005) (108)
- Empirical genomewide significance levels established by whole genome simulations (1997) (102)
- Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes (2012) (101)
- Fine genetic mapping using haplotype analysis and the missing data problem (1998) (100)
- A meta-analysis of genomic screens in multiple sclerosis. The Transatlantic Multiple Sclerosis Genetics Cooperative. (2001) (96)
- Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. (1996) (91)
- A genome-wide search for susceptibility loci to human essential hypertension. (2000) (90)
- PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes (2008) (87)
- Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes. (2001) (87)
- Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13 (2008) (85)
- Experimental aspects of copy number variant assays at CCL3L1 (2009) (85)
- Clinical concordance in sibling pairs with multiple sclerosis (1996) (85)
- A Method to Address Differential Bias in Genotyping in Large-Scale Association Studies (2007) (79)
- Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. (2012) (79)
- Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension. (1998) (76)
- Be skeptical about unexpected large apparent treatment effects: the case of an MRC AML12 randomization. (2003) (76)
- Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis. (2000) (75)
- Multiple sclerosis and the HLA-D region: linkage and association studies (1995) (74)
- Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene. (2003) (70)
- Age-related macular degeneration: the importance of family history as a risk factor (2011) (68)
- Extreme Clonality in Lymphoblastoid Cell Lines with Implications for Allele Specific Expression Analyses (2008) (65)
- Sex chromosomes and genetic association studies (2009) (58)
- Cost-effective analysis of candidate genes using htSNPs: a staged approach (2004) (54)
- Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness: a study of 8- to 18-yr-old twins. (2000) (54)
- No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. (2005) (49)
- Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping. (2006) (47)
- Detecting association using epistatic information (2007) (47)
- Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia (2001) (45)
- The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. (2007) (43)
- No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs. (1994) (40)
- The T-cell receptor beta locus and susceptibility to multiple sclerosis (1995) (39)
- On inferring presence of an individual in a mixture: a Bayesian approach (2010) (39)
- Choosing a set of haplotype tagging SNPs from a larger set of diallelic loci (2001) (36)
- SNP allele frequency estimation in DNA pools and variance components analysis. (2004) (36)
- Patterns of disease in concordant parent–child pairs with multiple sclerosis (2001) (33)
- Exploring the dense mapping of a region of potential linkage in complex disease: An example in multiple sclerosis (1999) (30)
- Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. (2006) (28)
- Genetic variation in complement regulators and susceptibility to age-related macular degeneration (2012) (28)
- Complement Factor H Variant Y 402 H Is a Major Risk Determinant for Geographic Atrophy and Choroidal Neovascularization in Smokers and Nonsmokers (2006) (24)
- Link Functions in Multi-Locus Genetic Models: Implications for Testing, Prediction, and Interpretation (2012) (24)
- Bayes Estimates of Haplotype Effects (2001) (24)
- No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration (2011) (24)
- Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis. (1997) (22)
- Genotypic relative risks under ordered restriction (1998) (21)
- No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases (2006) (16)
- Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB – FKBPL – NOTCH 4 region of chromosome 6 p 21 . 3 (2012) (16)
- Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene (2003) (10)
- Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region (1995) (9)
- Transplants from living donors in the United Kingdom and Ireland: a centre survey. (1989) (8)
- One degree of freedom for dominance in indirect association studies (2007) (7)
- Estimating the relative recurrence risk ratio using a global cross‐ratio model (2003) (7)
- Extra-binomial variation approach for analysis of pooled DNA sequencing data (2012) (7)
- No linkage between multiple sclerosis and the T cell receptor alpha chain locus. (1994) (6)
- No Evidence of Association or Interaction between the IL 4 RA , IL 4 , and IL 13 Genes in Type 1 Diabetes (2005) (6)
- Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design (2002) (4)
- Appropriate Use of Information on Family History of Disease in Recruitment for Linkage Analysis Studies (2006) (4)
- Genome scan for association and linkage (1995) (3)
- Validity of the Family-Based Association Test for Copy Number Variant Data in the Case of Non-Linear Intensity-Genotype Relationship (2012) (3)
- Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods (2003) (3)
- Complement C3 variant increases risk of age-related macular degeneration (2007) (2)
- Response to Kruglyak (1998) (2)
- Copy number variant association studies (2011) (2)
- 1.1 Genome wide search for susceptibility loci in essential hypertension: early results (1997) (1)
- Statistical Interactions and Gene-Environment Joint Effects (2012) (1)
- Living Donor Kidney Transplantation in the United Kingdom and Ireland: Does Donor-Recipient Age Difference Matter? (1991) (0)
- General score tests for regression models incorporating 'robust' variance estimates (2002) (0)
- An extended tTDT test for uncertain haplotype transmission (1999) (0)
- Imputed SNP analyses and meta-analysis with snpStats (2016) (0)
- Size of Affected Sibling Pairs Used in First Pass of Genome-Wide Screen (2000) (0)
- Imputed SNP analyses and meta-analysis with snpMatrix (2008) (0)
- Association between the ancestral haplotype A30-B18-DR3 and multiple sclerosis in central Sardinia (1999) (0)
- Searching for Genetic Association Using (Haplotype) Tagging SNPs (2004) (0)
- PCA vignette Principal components analysis with snpStats (2016) (0)
- EDITORIALS Betting Odds and Genetic Associations (2004) (0)
- Modelling admixture and extracting information about linkage that is generated by admixture from marker genotypes (2001) (0)
- No Association of the Angiotensin–converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism With Age–related Macular Degeneration (2005) (0)
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