David Gadsby | Academic Influence

David Gadsby's AcademicInfluence.com Rankings

David Gadsby

Biology

#14537

World Rank

#18310

Historical Rank

Physiology

#490

World Rank

#733

Historical Rank

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Biology

David Gadsby's Degrees

Bachelors Biology University of Oxford

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Why Is David Gadsby Influential?

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According to Wikipedia, David Christopher Gadsby FRS was a British physiologist, and Patrick A. Gerschel Family Professor Emeritus at The Rockefeller University. He was best known for his studies on the mechanisms by which ions move across cell membranes.

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David Gadsby's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The ABC protein turned chloride channel whose failure causes cystic fibrosis (2006) (687)
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. (1999) (434)
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains (2005) (428)
Ion channels versus ion pumps: the principal difference, in principle (2009) (389)
Molecular Structure of the Human CFTR Ion Channel (2017) (353)
Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes (1989) (271)
Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. (1994) (270)
[Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes (1989) (263)
Voltage dependence of Na/K pump current in isolated heart cells (1985) (246)
Voltage dependence of Na translocation by the Na/K pump (1986) (241)
Steady-state current-voltage relationship of the Na/K pump in guinea pig ventricular myocytes (1989) (219)
On the Mechanism of MgATP-dependent Gating of CFTR Cl− Channels (2003) (209)
Coupling of CFTR Cl− channel gating to an ATP hydrolysis cycle (1994) (207)
Extracellular access to the Na,K pump: pathway similar to ion channel. (1993) (192)
In vivo phosphorylation of CFTR promotes formation of a nucleotide‐binding domain heterodimer (2006) (190)
Stoichiometry and voltage dependence of the sodium pump in voltage- clamped, internally dialyzed squid giant axon (1989) (177)
Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase (2000) (163)
Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH2-terminal Nucleotide Binding Domain and its Role in Channel Gating (2003) (148)
The CFTR chloride channel of mammalian heart. (1995) (145)
Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels (2002) (136)
Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains (2000) (129)
ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR. (1997) (128)
STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL. (2019) (123)
Voltage dependence of the Na/K pump. (1997) (120)
Strict coupling between CFTR’s catalytic cycle and gating of its Cl− ion pore revealed by distributions of open channel burst durations (2009) (112)
Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart (1993) (112)
Large Diameter of Palytoxin-induced Na/K Pump Channels and Modulation of Palytoxin Interaction by Na/K Pump Ligands (2004) (105)
The Na/K pump of cardiac cells. (1984) (102)
Voltage Dependence of the Na/K Pump (1997) (102)
Ion Transport in Heart (1982) (95)
Ion transport: Spot the difference (2004) (89)
Potassium translocation by the Na+/K+ pump is voltage insensitive. (1988) (88)
Severed Molecules Functionally Define the Boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator's Nh2-Terminal Nucleotide Binding Domain (2000) (81)
Regulation of CFTR channel gating. (1994) (77)
The ion pathway through the opened Na+,K+-ATPase pump (2008) (72)
Preferential Phosphorylation of R-domain Serine 768 Dampens Activation of CFTR Channels by PKA (2005) (71)
Ion permeation through the Na+,K+-ATPase (2006) (71)
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance (1992) (68)
Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps (2014) (68)
Functional Roles of Nonconserved Structural Segments in CFTR's NH2-terminal Nucleotide Binding Domain (2005) (60)
β-Adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres (1983) (57)
Regulation of CFTR Cl- ion channels by phosphorylation and dephosphorylation. (1999) (57)
The dynamic relationships between the three events that release individual Na+ ions from the Na+/K+-ATPase (2012) (56)
Thermodynamics of CFTR Channel Gating: A Spreading Conformational Change Initiates an Irreversible Gating Cycle (2006) (54)
Peering into an ATPase ion pump with single-channel recordings (2009) (44)
Ouabain affinity determining residues lie close to the Na/K pump ion pathway (2006) (41)
Control of the CFTR channel's gates. (2005) (37)
Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump (2017) (37)
Introduction. The blurred boundary between channels and transporters (2009) (36)
The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions (2010) (33)
Voltage Dependence of the Apparent Affinity for External Na+ of the Backward-Running Sodium Pump (2001) (31)
Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels (2015) (31)
Do Intracellular Concentrations of Potassium or Sodium Regulate the Strength of the Heart Beat? (1971) (28)
Charge movements via the cardiac Na,K-ATPase. (1992) (26)
Structural biology: Ion pumps made crystal clear (2007) (26)
Single Ion Occupancy and Steady-state Gating of Na Channels in Squid Giant Axon (2002) (25)
Na/K-ATPase and related transport ATPases : structure, mechanism, and regulation (1997) (23)
Distinct Mg2+-dependent Steps Rate Limit Opening and Closing of a Single CFTR Cl− Channel (2002) (22)
Regulation of CFTR channel gating. (1994) (22)
Sodium Flux Ratio in Na/K Pump-Channels Opened by Palytoxin (2007) (21)
ATP hydrolysis cycles and the gating of CFTR Cl- channels. (1998) (21)
Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid (2011) (16)
Visualizing the mapped ion pathway through the Na,K-ATPase pump (2009) (12)
Chapter 11 Chloride Ion Channels in Mammalian Heart Cells (1994) (11)
Beta-adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres. (1983) (11)
Chapter 2 Hyperpolarization of Frog Skeletal Muscle Fibers and of Canine Cardiac Purkinje Fibers during Enhanced Na+-K+ Exchange: Extracellular K+ Depletion or Increased Pump Current? (1982) (8)
10 – Electrophysiologic Characteristics of Cardiac Cells and the Genesis of Cardiac Arrhythmias (1981) (8)
Paul F. Cranefield, M.D., Ph.D. April 28, 1925 to May 31, 2003 (2003) (8)
Voltage-induced Na/K pump charge movements in dialyzed heart cells. (1991) (7)
Chapter 14 Voltage Dependence of Na/K Pump Current (1989) (7)
Cftr Channel Gating (1999) (7)
Voltage dependence of transient and steady-state Na/K pump currents in myocytes (1989) (7)
Voltage Sensitivity of the Na+/K+ Pump: Structural Implications (1994) (6)
Two-bit anion channel really shapes up (1996) (6)
Dependence of the Na / K Pump Current-Voltage Relationship in Guinea Pig Ventricular Myocytes (2003) (5)
Voltage dependence of transient and steady-state Na/K pump currents in myocytes☆ (1988) (5)
Influence of Na/K pump current on action potentials in Purkinje fibers. (1985) (5)
Overview: stoichiometry and voltage dependence of the Na/K pump. (1988) (5)
Extent of Nucleotide-Binding Domain (NBD) Separation When a CFTR Channel Closes (2011) (4)
The ion pathway through the opened Na 1 , K 1-ATPase pump (2008) (4)
Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation. (2011) (3)
Ordered Interaction of Ions with Na/K‐Pump May Confound Interpretation of Unidirectional Fluxes a (1997) (2)
Introduction (1997) (2)
[On the mechanism of beta-adrenergic activation of cardiac outward currents--chloride and delayed rectifier potassium conductance]. (1992) (2)
NBD1 might remain nucleotide-bound throughout CFTR channel gating (2002) (2)
Effects on CFTR Cl- channel gating of Walker A lysine mutation K464A imply allosteric interaction between NBDS (2002) (2)
Generation, expression, and function of cysteine-less CFTR (2002) (1)
Influence of the sodium pump current on electrical activity of cardiac cells. (1984) (1)
Proton Current through Stalled Na/K-ATPase Pumps: Three Residues Point to a Possible Route and Mechanism (2013) (1)
Distinct Mg 2 -dependent Steps Rate Limit Opening and Closing of a Single CFTR Cl (cid:3) Channel (2002) (1)
Strict Coupling Between CFTR's Catalytic Cycle and Gating of its Channel Pore Revealed by Distributions of Open Burst Durations (2010) (1)
CFTR, an Ion Channel Evolved from an ABC Transporter (2012) (1)
Voltage-Clamp Measurement of Steady State Currents and Isotope Flux (1991) (0)
Separation and Accessibility of the Nucleotide-Binding Domain (NBD) Heterodimerization Interface When a CFTR Channel Closes (2012) (0)
Cell and molecular physiology. Modulation of membrane transport systems (1988) (0)
The Route and Mechanism of Uncoupled Current Flow through Na/K-ATPase Pumps Lacking the Two COOH-Terminal Tyrosines (2010) (0)
Roles of ATP binding and hydrolysis in CFTR Cl- channel gating (2001) (0)
β-Exodomain Role in Na/K-ATPase α-β Subunit Interactions (2013) (0)
CFTR: an ABC transporter turned channel (2006) (0)
100 and 50 years ago (2004) (0)
PKA Activation in Cardiac Myocytes Affects the Voltage Dependence of Na-K ATPase Pump and Na-Ca Exchange Currents Differently (2012) (0)
beta-Exodomain Role in Na/K-ATPase alpha-beta Subunit Interactions (2013) (0)
Truncation Of The Na/K Pump's C-terminus Attenuates Voltage-dependent Binding Of External Na+ By Destabilizing Na+ Occlusion (2009) (0)
Looking at Britain (1970) (0)
1 CFTR , AN ION CHANNEL EVOLVED FROM AN ABC TRANSPORTER Affiliation (2014) (0)
Characteristics of palytoxin-bound Na/K pump-channels mutated at their phosphorylation site (2007) (0)
Gating Ion Translocation through the Na,K-ATPase Pump (2012) (0)
On the Mechanism of β-adrenergic Activation of Cardiac Outward Currents : Chloride and Delayed Rectifier Potassium Conductance : Mechanism of intracellular regulation of cardiac ion channels and its abnormality (1993) (0)
Influence of Phosphate Analogs on Palytoxin-opened Na,K-ATPase Pump-channel (2009) (0)
Hybrid Function of the Na/K-ATPase: Proton Import Accompanying Na/K Exchange (2016) (0)
A tribute to Hiroshi Irisawa (1990) (0)
Functional Side Chain Interactions in ABCC Transporters Inferred by Improved Coevolution Analysis (2011) (0)
Na+ Access Kinetics in the Na+/K+-Atpase Pump (2012) (0)
The Na/K Pump of Cardiac Cells (1984) (0)
The 53rd Annual Meeting and Symposium of the Society of General Physiologists New Optical Methods in Cell Physiology (2000) (0)
Energetics of the Reactions Controlling the Deeply Occluded State of the Na+/K+ Pump (2012) (0)
Related Cation Pumps: Structures, Mechanisms, and (2006) (0)
CONTROL OF CFTR'S GATES BY ATP BINDING AND HYDROLYSIS (2010) (0)
Correction (2002) (0)
On the Mechanism of MgATP-dependent Gating of CFTR Cl (cid:2) Channels (2002) (0)
Voltage dependence of transient and steady currents generated by the Na/K pump in cardiac cells (1990) (0)
Side-Chain Carboxylate Needed for Nonstoichiometric Proton Leak through Na/K-ATPase Pumps (2011) (0)
Autonomic regulation of cardiac membrane currents (1993) (0)
Evolutionary and Mechanistic Insights into ABC Exporters (2012) (0)
Coevolving Amino Acid Positions in Exporter-Type ABC Proteins (2010) (0)

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