David H. Phillips
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Engineering Computer Science
David H. Phillips's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
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(Suggest an Edit or Addition)David H. Phillips's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Polycyclic aromatic hydrocarbons in the diet. (1999) (850)
- Mutational signatures associated with tobacco smoking in human cancer (2016) (722)
- Fifty years of benzo(a)pyrene (1983) (503)
- Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. (1997) (475)
- Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (2006) (431)
- Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. (1983) (405)
- A Compendium of Mutational Signatures of Environmental Agents (2019) (329)
- Correlation of DNA adduct levels in human lung with cigarette smoking (1988) (324)
- Heterogeneous DNA damage and repair in the mammalian genome. (1987) (294)
- Smoking-related DNA and protein adducts in human tissues. (2002) (292)
- Oxidative DNA damage mediated by copper(II), iron(II) and nickel(II) fenton reactions: evidence for site-specific mechanisms in the formation of double-strand breaks, 8-hydroxydeoxyguanosine and putative intrastrand cross-links. (1999) (284)
- Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients. (1999) (280)
- Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. (1992) (277)
- DNA adducts from chemotherapeutic agents. (1996) (274)
- Diversity of TMPRSS2-ERG fusion transcripts in the human prostate (2007) (270)
- CMS Physics : Technical Design Report Volume 1: Detector Performance and Software (2006) (265)
- Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients. (1994) (256)
- Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. (2000) (254)
- Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. (1999) (234)
- The 32P-postlabeling assay for DNA adducts (2007) (224)
- STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME): An Extension of the STROBE Statement (2011) (214)
- The exposome in practice: Design of the EXPOsOMICS project (2017) (206)
- Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. (2001) (197)
- Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme. (2009) (185)
- p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels. (1996) (185)
- Carcinogen-DNA adducts in human breast tissue. (1995) (183)
- 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice. (1984) (183)
- Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer. (2000) (177)
- Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack. (1997) (175)
- The genome as a record of environmental exposure (2015) (161)
- Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells (1990) (160)
- Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial. (2010) (159)
- Comparison of the formation of 8-hydroxy-2'-deoxyguanosine and single- and double-strand breaks in DNA mediated by fenton reactions. (1998) (148)
- DNA adducts in human environmentally exposed to aromatic compounds in an industrial area of Poland. (1990) (147)
- Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. (2001) (147)
- Lack of genotoxicity of tamoxifen in human endometrium. (1996) (145)
- Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide (1984) (144)
- Monitoring occupational exposure to carcinogens: detection by 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers. (1988) (141)
- Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice. (2007) (140)
- STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement. (2011) (140)
- From the exposome to mechanistic understanding of chemical-induced adverse effects. (2017) (137)
- Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts (2006) (136)
- Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. (2012) (130)
- Polycyclic Aromatic Hydrocarbons–Aromatic DNA Adducts in Cord Blood and Behavior Scores in New York City Children (2011) (130)
- Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue. (2000) (129)
- Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination. (1986) (125)
- Understanding the genotoxicity of tamoxifen? (2001) (125)
- Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. (2002) (122)
- DNA adducts as markers of exposure and risk. (2005) (122)
- Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells. (2010) (121)
- Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies. (2005) (121)
- Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. (2005) (121)
- Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer (2007) (120)
- Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway (2002) (120)
- Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles. (1994) (118)
- Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1'-hydroxyestragole. (1981) (117)
- DNA and protein adducts in human tissues resulting from exposure to tobacco smoke (2012) (117)
- Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen. (1996) (116)
- DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver. (2006) (115)
- Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. (2002) (114)
- Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2 (2006) (114)
- Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis. (1998) (113)
- An ECVAG† trial on assessment of oxidative damage to DNA measured by the comet assay (2009) (109)
- The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy (2013) (109)
- Damage to DNA in cervical epithelium related to smoking tobacco. (1993) (108)
- alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. (1994) (107)
- The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. (2009) (107)
- The covalent binding of polycyclic hydrocarbons to DNA in the skin of mice of different strains (1978) (104)
- Polymorphisms in the DNA Repair Enzyme XPD are Associated with Increased Levels of PAH–DNA Adducts in a Case-Control Study of Breast Cancer (2002) (104)
- DNA adducts: mass spectrometry methods and future prospects. (2005) (102)
- Heterocyclic aromatic amines induce DNA strand breaks and cell transformation. (1999) (101)
- Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes. (1986) (100)
- Polycyclic hydrocarbon activation: bay regions and beyond. (1994) (99)
- Genotoxicity: damage to DNA and its consequences. (2009) (97)
- AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. (2007) (96)
- Detection of DNA modifications by the 32P-postlabelling assay. (1997) (95)
- Polycyclic Aromatic Hydrocarbon (PAH) Exposure and DNA Adduct Semi-Quantitation in Archived Human Tissues (2011) (93)
- 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice. (1984) (93)
- Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes. (1996) (90)
- Exceptionally long‐term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy (2014) (89)
- Effects of mixing metal ions on oxidative DNA damage mediated by a Fenton-type reduction. (2008) (85)
- Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture. (1998) (85)
- TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy‐associated tumours (2009) (84)
- Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen. (1994) (82)
- Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism (2014) (82)
- Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase. (2003) (81)
- Inter-laboratory variation in DNA damage using a standard comet assay protocol. (2012) (80)
- The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis ('comet') assay in metabolically-competent MCL-5 cells. (1999) (79)
- Polymorphisms of the GSTP1 and GSTM1 genes and PAH‐DNA adducts in human mononuclear white blood cells (2000) (79)
- Activation of 3‐nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells (2003) (78)
- An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells. (2013) (77)
- DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. (2008) (76)
- Identification of three major DNA adducts formed by the carcinogenic air pollutant 3‐nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine (2006) (76)
- Boronic acids-a novel class of bacterial mutagen. (2011) (76)
- DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke. (1996) (75)
- Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer. (2009) (74)
- Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock‐in (Hupki) mouse model (2010) (74)
- Evidence for DNA and protein binding by styrene and styrene oxide. (1994) (70)
- STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement (2011) (69)
- Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway. (2002) (68)
- Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems. (1998) (68)
- Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene (2011) (68)
- STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement. (2011) (68)
- Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene (2015) (68)
- DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3‐nitrobenzanthrone in Muta Mouse (2004) (68)
- Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. (2009) (67)
- Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: a possible interaction with polymorphisms in the interleukin 1 beta gene. (2005) (67)
- Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosis. (1995) (67)
- Covalent binding of components of coal-tar, creosote and bitumen to the DNA of the skin and lungs of mice following topical application. (1988) (66)
- N2 atom of guanine and N6 atom of adenine residues as sites for covalent binding of metabolically activated 1'-hydroxysafrole to mouse liver DNA in vivo. (1981) (66)
- Covalent binding of dibenzpyrenes and benzo[a]pyrene to DNA: evidence for synergistic and inhibitory interactions when applied in combination to mouse skin. (1990) (66)
- GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels. (1999) (65)
- Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. (2012) (65)
- Detection and characterization by 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system. (1992) (65)
- Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients. (1998) (64)
- 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2. (2004) (64)
- Lack of evidence from HPLC 32P-post-labelling for tamoxifen-DNA adducts in the human endometrium. (1999) (62)
- Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon–DNA adduct levels in human prostate (2009) (62)
- Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases. (2006) (62)
- DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats. (2003) (61)
- Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model. (2011) (60)
- Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania (2012) (60)
- Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from coke oven workers: correlation with job categories. (1992) (58)
- Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse (2011) (58)
- The metabolic activation of tamoxifen and alpha-hydroxytamoxifen to DNA-binding species in rat hepatocytes proceeds via sulphation. (1998) (57)
- Genotoxicity of human mammary lipid. (1996) (57)
- Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture, and in mouse skin and lung following topical application of coal-tar and juniper tar. (1990) (57)
- Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells. (2011) (56)
- Validation of biomarkers for the study of environmental carcinogens: a review (2008) (56)
- Evidence for N-(deoxyguanosin-8-yl)-1-aminopyrene as a major DNA adduct in female rats treated with 1-nitropyrene. (1985) (56)
- N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. (2001) (54)
- THE ENVIRONMENTAL POLLUTANT AND CARCINOGEN 3-NITROBENZANTHRONE AND ITS HUMAN METABOLITE 3-AMINOBENZANTHRONE ARE POTENT INDUCERS OF RAT HEPATIC CYTOCHROMES P450 1A1 AND -1A2 AND NAD(P)H:QUINONE OXIDOREDUCTASE (2006) (53)
- Demonstration of smoking-related DNA damage in cervical epithelium and correlation with human papillomavirus type 16, using exfoliated cervical cells. (1995) (53)
- DNA damage in breast epithelial cells: detection by the single-cell gel (comet) assay and induction by human mammary lipid extracts. (1997) (53)
- Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse. (2008) (52)
- Mutational spectra and mutational signatures: Insights into cancer aetiology and mechanisms of DNA damage and repair (2018) (52)
- A biomarker model of sublethal genotoxicity (DNA single-strand breaks and adducts) using the sentinel organism Aporrectodea longa in spiked soil. (2005) (51)
- Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos (2016) (50)
- Subchronic Oral Exposure to Benzo(a)pyrene Leads to Distinct Transcriptomic Changes in the Lungs That Are Related to Carcinogenesis (2012) (50)
- Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. (2008) (50)
- Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells. (1990) (49)
- Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. (2014) (48)
- 32P-postlabeling analysis of DNA adducts. (2005) (48)
- 32P-postlabelling detection of aromatic DNA adducts in peripheral blood lymphocytes from aluminium production plant workers. (1991) (48)
- Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice (2011) (47)
- Formation and persistence of benzo[a]pyrene-DNA adducts in mouse epidermis in vivo: importance of adduct conformation. (1995) (47)
- Determination of the enzymes responsible for activation of the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline in the human breast. (1998) (46)
- DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes. (1998) (46)
- Interlaboratory comparison of the 32P-postlabelling assay for aromatic DNA adducts in white blood cells of iron foundry workers. (1989) (46)
- Inhibition by an extract of Ocimum sanctum of DNA-binding activity of 7,12-dimethylbenz[a]anthracene in rat hepatocytes in vitro. (1998) (46)
- Interindividual variation in the metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells. (1998) (46)
- Postlabeling and immunoassay analysis of polycyclic aromatic hydrocarbons--adducts of deoxyribonucleic acid in white blood cells of foundry workers. (1990) (45)
- Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung. (2004) (45)
- Gender-related differences in response to mutagens and carcinogens. (2010) (45)
- Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone. (2007) (44)
- Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L. (1991) (44)
- The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo. (2008) (44)
- STrengthening the Reporting of OBservational studies in Epidemiology — Molecular Epidemiology STROBE-ME: an extension of the STROBE statement [J Clin Epidemiol 2011;64(12):1350–1363] (2012) (44)
- TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts (2015) (43)
- Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells. (1996) (43)
- Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin. (1993) (43)
- Resveratrol inhibits benzo[a]pyrene–DNA adduct formation in human bronchial epithelial cells (2004) (43)
- Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B lymphoblastoid MCL-5 cells. (2004) (43)
- Analysis of the polycyclic aromatic hydrocarbon content of petrol and diesel engine lubricating oils and determination of DNA adducts in topically treated mice by 32P-postlabelling. (1990) (42)
- The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice (2015) (42)
- Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons. (1991) (42)
- Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats. (1994) (42)
- Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. (2011) (42)
- Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling. (2012) (42)
- Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone. (2010) (41)
- Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats. (2007) (41)
- Improved reversed-phase high-performance liquid chromatographic separation of 32P-labelled nucleoside 3',5'-bisphosphate adducts of polycyclic aromatic hydrocarbons. (1991) (41)
- Modern Methods of DNA Adduct Determination (1990) (41)
- Preparation of a methylated DNA standard, and its stability on storage. (2000) (39)
- Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice (2014) (39)
- Primary cultures of prostate cells and their ability to activate carcinogens (2002) (39)
- Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans. (2004) (37)
- DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. (2011) (37)
- Tamoxifen-DNA adduct formation in rat liver determined by immunoassay and 32P-postlabeling. (1999) (37)
- Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro‐carcinogens to DNA‐damaging metabolites (2010) (37)
- Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy. (2005) (37)
- Formation of DNA adducts in human skin maintained in short‐term organ culture and treated with coal‐tar, creosote or bitumen (1988) (36)
- The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox (2018) (36)
- Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse. (2008) (36)
- Carcinogenicity of acrolein, crotonaldehyde, and arecoline. (2020) (35)
- Aromatic DNA adducts in white blood cells of coke workers (1990) (35)
- Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy (2003) (34)
- Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53. (2008) (34)
- Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients. (1996) (34)
- DNA adduct formation by the environmental contaminant 3‐nitrobenzanthrone after intratracheal instillation in rats (2005) (34)
- DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay. (1993) (34)
- The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity. (2008) (34)
- Aromatic DNA adducts in white blood cells of foundry workers. (1988) (33)
- Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells. (2000) (32)
- Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice (2018) (32)
- Minor products of reaction of DNA with alpha-acetoxytamoxifen. (1997) (32)
- Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). (1990) (32)
- DNA adducts in cervical tissue of smokers and non-smokers. (1994) (32)
- Biomarkers of marine pollution observed in species of mullet living in two eastern Mediterranean harbours (1997) (32)
- DNA adduct formation in human and mouse skin by mixtures of polycyclic aromatic hydrocarbons. (1990) (31)
- On the origins and development of the (32)P-postlabelling assay for carcinogen-DNA adducts. (2013) (31)
- Structure, conformations, and repair of DNA adducts from dibenzo[a, l]pyrene: 32P-postlabeling and fluorescence studies. (1998) (31)
- N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells. (1999) (30)
- Pathways of heterocyclic amine activation in the breast: DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) formed by peroxidases and in human mammary epithelial cells and fibroblasts. (2000) (30)
- Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development. (2015) (29)
- Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation. (2007) (29)
- Further evidence that eugenol does not bind to DNA in vivo. (1990) (28)
- 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells. (2010) (28)
- Aberrant activation of benzo(a)pyrene in cultured rat mammary cells in vitro and following direct application to rat mammary glands in vivo. (1985) (28)
- Postlabelling methods for the detection of DNA adducts (1993) (28)
- Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories. (2014) (27)
- Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure. (2009) (27)
- EXPOsOMICS: final policy workshop and stakeholder consultation (2018) (27)
- The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans (2016) (27)
- In vitro reaction with DNA of the fjord-region diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene as studied by 32P-postlabeling. (1995) (27)
- Genotoxicity characteristics of reverse diol-epoxides of chrysene. (1993) (27)
- DNA adducts in humans related to occupational and environmental exposure to aromatic compounds. (1990) (27)
- 32P-postlabelling analysis of DNA adducts in the skin of mice treated with petrol and diesel engine lubricating oils and exhaust condensates. (1989) (27)
- ³²P-postlabeling analysis of DNA adducts. (2014) (27)
- Bulky DNA Adducts in White Blood Cells: A Pooled Analysis of 3,600 Subjects (2010) (26)
- Results of an interlaboratory trial of 32P-postlabelling. (1993) (26)
- Carcinogenicity of quinoline, styrene, and styrene-7,8-oxide. (2018) (26)
- Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene. (2002) (26)
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- Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone (2016) (0)
- Imaging and semiquantitation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human reproductive tissues. (2006) (0)
- Abstract 4701: DNA-adducts levels and chromosomal aberrations in relation to smoking history and topography in smokers (2010) (0)
- You are what you eat : diet and prostate cancer. (2001) (0)
- Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53 (vol 232, pg 86, 2008) (2018) (0)
- Abstract 2646: Genetic determinants of PAH-DNA adduct level and nucleotide excision repair among non-smokers in a high risk area for esophageal squamous cell carcinoma: (2012) (0)
- DNA adducts as markers of occupational, medical and environmental exposure to carcinogens (1991) (0)
- Impact of p53 on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone in human cells (2014) (0)
- Damage to DNA in Cervical Epithelium Related to Smoking Tobacco (1994) (0)
- Imaging and semiquantitation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human cervix, vuvla, placenta and prostate using Immunohistochemistry (ICH) and the Automated Cellular Imaging System (ACIS). (2006) (0)
- Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts Toxicology in Vitro (2014) (0)
- Action at the DNA level of a highly potent mutagen: 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000) (1989) (0)
- Model Studies on the in Vitro Activation of c-Ha-ras Protooncogene by Dietary Components (1988) (0)
- 202Do phase II metabolic enzymes activate dietary carcinogens in the human prostate? A study of N-acetyltransferase1 and sulfotransferaseia (2005) (0)
- Covalent binding of the dibenzpyrenes and benzo[a]pyrene to DNA: evidence for synergistic and inhibitory interactions when applied in combination to mouse skin (1991) (0)
- The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism (2010) (0)
- of DNA damage by the Comet assay in MCL-5 cells exposed to urban air particulate matter (2000) (0)
- Perspectivesin CancerResearch Heterogeneous DNA Damage and Repair in the Mammalian Genome1 (2006) (0)
- The and are associated with bulky DNA adduct levels in human leukocytes (2013) (0)
- Structure-Activity Studies of the Carcinogenicities in the Mouse and Rat of Some Naturally Occurring and Synthetic Alkenylbenzene Derivatives Related to Safrole and Estragà 3 le 1 (2006) (0)
- 890Altered expression of 5α reductase (SRD5A) isoforms in prostate cancer (2005) (0)
- The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice (2015) (0)
- Mechanisms of mitomycin c (MMC) toxicity in normal and Fanconi anemia cells: Quantitation of DNA adducts and oxidative damage. (1999) (0)
- NADH:cytochrome b5 reductase and cytochrome b5 act as sole electron donors to human cytochrome P450 1A1-catalyzed oxidation and DNA adduct formation by benzo[a]pyrene (2016) (0)
- Mutations activating human c-Ha-rasl protooncogene (HRASI) induced by chemical carcinogens and depurination (carcinogen-DNA adducts/DNA transfectlon/oligonucleotlde probes) (0)
- DNA-bound polycyclic aromatic hydrocarbons in white blood cell DNA of foundry workers (1987) (0)
- Structure-Activity Studies of the Carcinogenicities in the Mouse and Rat of Some Naturally Occurring and Synthetic Alkenylbenzene Derivatives Related to Safrole and Estragóle1 (2006) (0)
- State of validation of biomarkers of carcinogen exposure and effect. Generic biomarkers. (2007) (0)
- Impact of P53 on DNA damage and metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) in TRP53(+/+), TRP53(+/−) and TRP53(−/−) mice (2014) (0)
- 7 – Detection by 32P-postlabelling of Carcinogen–DNA Adducts in Animals and Man (1989) (0)
- Mechanisms of Liver Carcinogenesis by Antiestrogens (2009) (0)
- Organ specificity of DNA adduct formation by tamoxifen and a -hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment (2005) (0)
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