David Horn
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Computer Science
David Horn 's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
- Bachelors Computer Science University of California, Berkeley
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Why Is David Horn Influential?
(Suggest an Edit or Addition)According to Wikipedia, David Horn FRSE, is a Wellcome Trust Senior Investigator, professor of parasite molecular biology, deputy head of the Division of Biological Chemistry and Drug Discovery and deputy director of the Wellcome Trust Centre for Anti-Infectives Research in the School of Life Sciences, University of Dundee. His research is focused on antigenic variation, drug action and resistance and the application of genetic screens to African trypanosomes: parasitic protists that cause sleeping sickness or Human African Trypanosomiasis and the livestock disease, nagana.
David Horn 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Genome of the Kinetoplastid Parasite, Leishmania major (2005) (1355)
- The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease (2005) (1341)
- High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. (2011) (434)
- A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes (2008) (378)
- High-throughput decoding of anti-trypanosomal drug efficacy and resistance (2011) (311)
- Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2017) (297)
- Histone deacetylases. (2008) (294)
- Antigenic variation in African trypanosomes (2014) (261)
- Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. (2013) (210)
- Genome wide dissection of the quorum sensing signaling pathway in Trypanosoma brucei (2013) (191)
- A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei. (2005) (165)
- Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. (2005) (151)
- Molecular mechanisms underlying the control of antigenic variation in African trypanosomes (2010) (143)
- A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei (1995) (143)
- Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes (2012) (143)
- Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. (2008) (139)
- A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation (2007) (128)
- Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6 (2011) (123)
- NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions (2012) (116)
- Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs (2013) (114)
- Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes (2008) (113)
- RNA Interference Identifies Two Hydroperoxide Metabolizing Enzymes That Are Essential to the Bloodstream Form of the African Trypanosome* (2003) (109)
- Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome (2006) (92)
- DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes (2013) (91)
- Position‐dependent and promoter‐specific regulation of gene expression in Trypanosoma brucei (1997) (87)
- Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition (2019) (87)
- Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. (2006) (86)
- Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids (2008) (84)
- Trypanosomal histone γH2A and the DNA damage response (2012) (83)
- Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol (2013) (83)
- VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes (2016) (82)
- Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes (2010) (79)
- Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes (2008) (77)
- Melarsoprol Resistance in African Trypanosomiasis. (2018) (71)
- Analysis of Trypanosoma brucei vsg expression site switching in vitro. (1997) (71)
- The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes (2005) (68)
- Microhomology-mediated deletion and gene conversion in African trypanosomes (2010) (68)
- Clinical and veterinary trypanocidal benzoxaboroles target CPSF3 (2018) (67)
- Codon usage bias controls mRNA and protein abundance in trypanosomatids (2018) (66)
- Genetic manipulation indicates that ARD1 is an essential N(alpha)-acetyltransferase in Trypanosoma brucei. (2000) (63)
- Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control (2013) (62)
- Vitamin C biosynthesis in trypanosomes: a role for the glycosome. (2005) (62)
- Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression (2002) (62)
- Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei (2007) (60)
- Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei (2012) (59)
- Genetic dissection of drug resistance in trypanosomes (2013) (56)
- PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome (2013) (56)
- Antiparasitic chemotherapy: from genomes to mechanisms. (2014) (56)
- Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA (2013) (54)
- Repression of polymerase I‐mediated gene expression at Trypanosoma brucei telomeres (2006) (52)
- Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest (2007) (51)
- Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes (2014) (51)
- Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex (2019) (50)
- Down-regulating gene expression by RNA interference in Trypanosoma brucei. (2005) (48)
- Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa (2016) (47)
- Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2 (2016) (45)
- Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei (2017) (43)
- Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes (2018) (43)
- Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole (2006) (42)
- Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani (2018) (41)
- Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei (2009) (40)
- Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates (2015) (40)
- Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes (2015) (38)
- Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes (2015) (37)
- The molecular control of antigenic variation in Trypanosoma brucei. (2004) (36)
- Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy. (2013) (36)
- Insights into antitrypanosomal drug mode-of-action from cytology-based profiling (2018) (34)
- Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei (2014) (33)
- Telomere maintenance and length regulation in Trypanosoma brucei (2000) (32)
- Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei (2018) (32)
- Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity (2017) (32)
- Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes (2011) (31)
- Exploiting the Achilles’ heel of membrane trafficking in trypanosomes (2016) (31)
- Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes (2021) (30)
- Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes (2012) (29)
- What has DNA sequencing revealed about the VSG expression sites of African trypanosomes? (2009) (29)
- Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei (2018) (26)
- Telomeres, tethers and trypanosomes (2012) (26)
- Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles (2018) (25)
- Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome (2019) (24)
- Nuclear gene transcription and chromatin in Trypanosoma brucei. (2001) (23)
- Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome (2014) (23)
- Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense (2016) (23)
- Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression (2016) (22)
- Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei (2012) (21)
- High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes (2016) (20)
- Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei (2017) (20)
- Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes (2020) (20)
- Introducing histone modification in trypanosomes. (2007) (20)
- The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei* (2016) (18)
- Setting Our Sights on Infectious Diseases (2019) (17)
- Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals (2018) (16)
- Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei (2019) (16)
- Anti-trypanosomatid drug discovery: progress and challenges (2022) (13)
- A post-transcriptional respiratome regulon in trypanosomes (2019) (13)
- High‐Throughput Decoding of Drug‐Targets and Drug‐Resistance Mechansims in African Trypanosomes (2013) (13)
- Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei (2017) (12)
- Corrigendum: Anti-trypanosomatid drug discovery: An ongoing challenge and a continuing need (Nature Reviews Microbiology (2017) 15 (217-231) DOI: 10.1038/nrmicro.2016.193) (2017) (12)
- Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2018) (12)
- Multiplex analysis of RNA interference defects in Trypanosoma brucei. (2005) (12)
- Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (2020) (11)
- Antigenic Variation: Extending the Reach of Telomeric Silencing (2009) (10)
- RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei. (2007) (9)
- Trypanosoma brucei J protein 2 is a stress inducible and essential Hsp40. (2015) (9)
- RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease (2010) (9)
- A profile of research on the parasitic trypanosomatids and the diseases they cause (2022) (8)
- Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei (2020) (8)
- Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites (2018) (8)
- DNA breaks as triggers for antigenic variation in African trypanosomes (2009) (7)
- Ecological Control of Insects (1999) (7)
- Genome-scale RNAi screens in African trypanosomes. (2021) (6)
- Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF 1 A and CAF-1 b in Trypanosoma brucei (2012) (6)
- Analysis of small GTPase function in trypanosomes. (2008) (6)
- Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs (2017) (4)
- Directional enrichment of directly cloned PCR products. (2005) (4)
- Antigenic variation by switching inter-chromosomal interactions with an RNA splicing locus in trypanosomes (2020) (3)
- Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis (2022) (3)
- Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis (2022) (2)
- Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease (2021) (2)
- Genome Rearrangement of the Rhizobiaceae (1983) (2)
- RNA polymerase I transcription stimulates homologous recombination in T. brucei (2013) (2)
- Chromosome structure and dynamics. (2007) (2)
- Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2018) (2)
- Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes (2015) (1)
- Trypanosoma brucei Subtelomeres: Monoallelic Expression and Antigenic Variation (2014) (1)
- Inter-chromosomal k-mer distances (2021) (1)
- CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes. (2022) (1)
- Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects (2022) (1)
- Genome-scale functional profiling of cell cycle controls in African trypanosomes (2020) (1)
- Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids (2022) (1)
- University of Dundee Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging (2017) (0)
- Inhibitor CpdA Resistance to the Phosphodiesterase RNA Interference Library Screening for Trypanosomes Revealed by Genome-Scale Cyclic AMP Effectors in African (2013) (0)
- Molecular & Biochemical Parasitology Trypanosomal histone H2A and the DNA damage response (2018) (0)
- Author Correction: Anti-trypanosomatid drug discovery: progress and challenges (2022) (0)
- How Antiparasitic Drugs Work—And Sometimes Stop Working! (2016) (0)
- Structure of TbALDH3 complexed with NAD and AN3057 aldehyde (2017) (0)
- Perspectives for the control of tuberculosis. (1995) (0)
- Para-Site-Seeing (2020) (0)
- Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense (2016) (0)
- Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex (2019) (0)
- Erratum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (2017) (0)
- University of Dundee Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa Duraisingh (0)
- University of Dundee Instability of aquaglyceroporin (Aqp) 2 contributes to drug resistance in trypanosoma (2020) (0)
- Mäser, P. (2015) Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei (2015) (0)
- The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis (2023) (0)
- Characterisation of genomic and cDNA clones of the small ribonucleoprotein SmN (1991) (0)
- University of Dundee Antigenic variation in African trypanosomes (2017) (0)
- University of Dundee Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol Graf, (2013) (0)
- Compositional order of proteins, a novel perspective on evolution (2013) (0)
- University of Dundee Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals (2018) (0)
- High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes (2016) (0)
- Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites (2017) (0)
- Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei (2023) (0)
- Structure of apo-TbALDH3 (2017) (0)
- Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes (2018) (0)
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