David J. Waxman
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American professor of biology
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Biology
David J. Waxman's Degrees
- PhD Biology Stanford University
- Masters Biology Stanford University
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)David J. Waxman's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. (1996) (2884)
- The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. (1993) (1640)
- Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. (1997) (995)
- P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. (1999) (763)
- An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids (2001) (747)
- Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. (1986) (743)
- Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes (2009) (613)
- Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. (1985) (574)
- Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. (1993) (559)
- Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics. (1983) (548)
- Phenobarbital induction of cytochrome P-450 gene expression. (1992) (546)
- Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. (1989) (461)
- Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. (1988) (439)
- Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. (1988) (439)
- Activation of PPARα and PPARγ by Environmental Phthalate Monoesters (2003) (417)
- Growth hormone regulation of sex-dependent liver gene expression. (2006) (406)
- Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. (1983) (363)
- SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple Mechanisms* (1999) (359)
- Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. (1991) (334)
- trans-activation of PPARα and PPARγ by structurally diverse environmental chemicals (1999) (333)
- Combination of antiangiogenesis with chemotherapy for more effective cancer treatment (2008) (317)
- MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets (2012) (310)
- Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. (1999) (304)
- Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. (1994) (271)
- Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. (1994) (270)
- Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. (1997) (264)
- Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. (1991) (260)
- Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review. (1990) (257)
- Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. (2000) (253)
- Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein. (1995) (245)
- Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme. (1984) (240)
- Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. (1995) (235)
- Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver (1996) (227)
- Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. (2006) (219)
- Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase* (1997) (209)
- Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. (1997) (206)
- Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. (1992) (202)
- Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy. (2018) (194)
- Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation. (1989) (193)
- Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms. (1982) (184)
- Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance. (2015) (176)
- STAT5b is required for GH-induced liver IGF-I gene expression. (2001) (173)
- trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. (1999) (172)
- Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. (2003) (171)
- Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. (1990) (171)
- Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression (1999) (163)
- Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. (1995) (161)
- Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450. (1986) (157)
- Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. (1994) (156)
- Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease (2011) (149)
- Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. (2004) (147)
- trans-Activation of PPARα and Induction of PPARα Target Genes by Perfluorooctane-Based Chemicals (2004) (145)
- Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. (2004) (145)
- Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR) (2006) (144)
- Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. (1997) (137)
- Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. (1996) (137)
- Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. (1990) (134)
- Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. (1988) (132)
- Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. (2001) (131)
- Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver (2011) (124)
- 17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement. (1986) (123)
- Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone* (2000) (123)
- Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-α (PPARα) Signaling Pathways (1999) (119)
- Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver (2013) (118)
- Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. (1997) (117)
- Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5. (1983) (117)
- Harnessing apoptosis for improved anticancer gene therapy. (2003) (114)
- Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver flavin adenine dinucleotide containing monooxygenase. (1982) (114)
- Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. (1995) (113)
- Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. (1992) (112)
- Use of reverse transcription–polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods (1994) (112)
- Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases. (1979) (109)
- Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene. (1996) (108)
- Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha. (2006) (105)
- Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression. (2000) (103)
- P450 enzyme expression patterns in the NCI human tumor cell line panel. (2001) (94)
- Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression (2010) (92)
- STAT5 signaling in sexually dimorphic gene expression and growth patterns. (1999) (91)
- Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. (1989) (91)
- Growth Hormone Determines Sexual Dimorphism of Hepatic Cytochrome P450 3A4 Expression in Transgenic Mice (2006) (90)
- Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. (2008) (90)
- STAT5b-deficient Mice Are Growth Hormone Pulse-resistant (1999) (89)
- Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. (2007) (89)
- Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene. (1997) (88)
- Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. (2004) (87)
- Regulation of liver-specific steroid metabolizing cytochromes P450: Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases (1992) (87)
- Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. (1992) (86)
- Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy. (1998) (86)
- Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids. (1990) (85)
- Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity. (2001) (84)
- Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. (1994) (83)
- Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory (2015) (82)
- Directed Evolution of Mammalian Cytochrome P450 2B1 (2005) (82)
- VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. (2012) (81)
- Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver. (2000) (81)
- Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liver. (2010) (81)
- In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (1999) (80)
- Sex-specific early growth hormone response genes in rat liver. (2008) (80)
- Chiral sulfoxidations catalyzed by rat liver cytochromes P-450. (1982) (79)
- Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells. (1994) (79)
- Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;. (1990) (79)
- Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. (1996) (78)
- STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain* (1999) (78)
- Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. (1990) (77)
- Changes in cytochromes P-450, 2E1, 2B1, and 4A, and phospholipases A and C in the intragastric feeding rat model for alcoholic liver disease: relationship to dietary fats and pathologic liver injury. (1994) (76)
- Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: pituitary control of hepatic NADPH cytochrome P-450 reductase. (1989) (76)
- CANCER CHEMOTHERAPY AND DRUG METABOLISM (2005) (75)
- Termination of growth hormone pulse-induced STAT5b signaling. (1999) (75)
- Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation. (1999) (75)
- Inhibitory Cross-talk between STAT5b and Liver Nuclear Factor HNF3β (2001) (74)
- Sequence of active site peptides from the penicillin-sensitive D-alanine carboxypeptidase of Bacillus subtilis. Mechanism of penicillin action and sequence homology to beta-lactamases. (1980) (73)
- Cytochrome P450-based cancer gene therapy: recent advances and future prospects. (1999) (73)
- Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450. (1989) (73)
- Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer. (2002) (72)
- Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. (1989) (72)
- Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. (2009) (71)
- Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib (2008) (70)
- Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes. (1993) (69)
- Role of the Cytokine-induced SH2 Domain-containing Protein CIS in Growth Hormone Receptor Internalization* (2005) (69)
- The structural basis of pregnane X receptor binding promiscuity. (2009) (67)
- Mini ReviewRole of Hepatocyte Nuclear Factors in Growth Hormone-regulated, Sexually Dimorphic Expression of Liver Cytochromes P450* (2004) (67)
- Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. (2004) (67)
- Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes. (1991) (66)
- Growth Hormone, but Not Prolactin, Maintains Low-Level Activation of STAT5a and STAT5b in Female Rat Liver. (1999) (66)
- Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. (2001) (65)
- Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. (2007) (64)
- Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer. (1999) (64)
- Mechanisms of cyclophosphamide action on hepatic P-450 expression. (1990) (64)
- Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. (2005) (63)
- Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer. (2006) (63)
- Interaction of anticancer drugs with hepatic monooxygenase enzymes. (1989) (63)
- Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood (2012) (63)
- Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes. (1988) (63)
- Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene (2006) (62)
- Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. (1990) (62)
- Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver. (1987) (62)
- Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. (1996) (60)
- Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. (2000) (60)
- Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. (1998) (60)
- Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. (1988) (60)
- PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis (2010) (60)
- Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: relationship to cytochrome P-450 2E1 induction and conjugated diene formation. (1993) (59)
- Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450. (1996) (58)
- Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. (2004) (58)
- Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations. (1987) (58)
- Down-Regulation of STAT5b Transcriptional Activity by Ligand-Activated Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARγ (2003) (57)
- Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. (1992) (57)
- Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression. (2014) (57)
- Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. (2004) (56)
- [44] P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography (1991) (56)
- Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone. (1991) (55)
- Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats. (1994) (55)
- Impact of CUX2 on the Female Mouse Liver Transcriptome: Activation of Female-Biased Genes and Repression of Male-Biased Genes (2012) (55)
- Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis. (1980) (55)
- Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. (1998) (55)
- Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver. (1993) (54)
- trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals. (2004) (54)
- Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. (2000) (53)
- Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. (1987) (53)
- Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy. (2001) (53)
- Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. (2007) (52)
- Use of Replication-Conditional Adenovirus as a Helper System to Enhance Delivery of P450 Prodrug-Activation Genes for Cancer Therapy (2004) (52)
- Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide. (1989) (52)
- Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes. (1991) (51)
- Conditionally replicating adenoviruses for cancer treatment. (2007) (51)
- Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. (2006) (50)
- Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model. (2016) (50)
- Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States (2017) (50)
- Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH action. (2000) (49)
- Antiangiogenesis enhances intratumoral drug retention. (2011) (48)
- Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model. (2014) (48)
- Liver Cytochrome P450 Metabolism of Endogenous Steroid Hormones, Bile Acids, and Fatty Acids (1993) (46)
- Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression. (2000) (46)
- Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites. (2009) (45)
- ENANTIOSELECTIVE METABOLISM AND CYTOTOXICITY OF R-IFOSFAMIDE AND S-IFOSFAMIDE BY TUMOR CELL-EXPRESSED CYTOCHROMES P450 (2005) (44)
- Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver (2018) (44)
- Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed. (2003) (44)
- Dominant Effect of Antiangiogenesis in Combination Therapy Involving Cyclophosphamide and Axitinib (2009) (43)
- Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats. (1987) (43)
- The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies. (1985) (43)
- Interaction of a Novel Sex-dependent, Growth Hormone-regulated Liver Nuclear Factor with CYP2C12 Promoter* (1996) (42)
- Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism. (1995) (41)
- Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses (2017) (41)
- Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells. (1995) (41)
- Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo. (1989) (41)
- PENICILLIN-BINDI NG PROTEINS AND THE MECHANISM OF ACTION OF P-LACTAM ANTIBIOTICS 1 (1983) (40)
- Preparation and characterization of monoclonal antibodies to pregnenolone 16-α-carbonitrile inducible rat liver cytochrome P-450☆ (1986) (39)
- Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model (2000) (39)
- Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11 (2006) (39)
- Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome (2016) (39)
- Environmental and Endogenous Peroxisome Proliferator-Activated Receptor γ Agonists Induce Bone Marrow B Cell Growth Arrest and Apoptosis: Interactions between Mono(2-ethylhexyl)phthalate, 9-cis-Retinoic Acid, and 15-Deoxy-Δ12,14-prostaglandin J21 (2004) (39)
- Growth hormone-dependent and -independent sexually dimorphic regulation of phenobarbital-induced hepatic cytochromes P450 2B1 and 2B2. (1994) (39)
- Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth hormone regulating expression of sex-dependent forms of cytochrome P450. (1991) (39)
- Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450. (1988) (38)
- Medium Dose Intermittent Cyclophosphamide Induces Immunogenic Cell Death and Cancer Cell Autonomous Type I Interferon Production in Glioma Models. (2019) (38)
- Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. (2008) (38)
- Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event (2016) (38)
- Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms? (1992) (37)
- Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer. (2003) (37)
- Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5 alpha-reductase. (1990) (36)
- Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs. (1992) (36)
- Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting (2020) (36)
- Sexual Dimorphism of Rat Liver Nuclear Proteins (2004) (36)
- Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450. (1990) (36)
- Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo. (1998) (35)
- Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. (1998) (35)
- Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated by stat5b. (1999) (35)
- Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes. (1989) (35)
- Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase. (1990) (33)
- Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone (2015) (33)
- Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism. (1989) (33)
- Phosphorylation of carcinogen metabolizing enzymes: regulation of the phosphorylation status of the major phenobarbital inducible cytochromes P-450 in hepatocytes. (1989) (33)
- Targeting Drug-Metabolizing Enzymes for Effective Chemoprevention and Chemotherapy (2010) (33)
- Role of Hepatocyte Nuclear Factors in Transcriptional Regulation of Male-specific CYP2A2* (2005) (33)
- Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization. (1987) (33)
- Multi‐modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models (2018) (33)
- Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver (2017) (32)
- Changes in Mouse Uterine Transcriptome in Estrus and Proestrus1 (2013) (32)
- Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1. (1986) (31)
- Computational screening of phthalate monoesters for binding to PPARgamma. (2006) (31)
- Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate. (1993) (31)
- N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents. (1991) (31)
- Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. (2006) (31)
- Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver. (2015) (31)
- Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma. (2003) (30)
- Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators (2016) (30)
- Modulation of cyclophosphamide-based cytochrome P 450 gene therapy using liver P450 inhibitors (2001) (30)
- Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (2006) (29)
- Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor (2000) (29)
- Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. (2006) (29)
- Antitumor alkylating agents: in vitro cross-resistance and collateral sensitivity studies (2004) (29)
- Dehydroepiandrosterone 3 beta-sulphate is an endogenous activator of the peroxisome-proliferation pathway: induction of cytochrome P-450 4A and acyl-CoA oxidase mRNAs in primary rat hepatocyte culture and inhibitory effects of Ca(2+)-channel blockers. (1994) (29)
- CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model. (2016) (29)
- The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation. (1993) (28)
- Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard. (1993) (28)
- Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35. (2002) (28)
- Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. (2006) (27)
- Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene. (1997) (27)
- Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. (2002) (27)
- Functional Roles of Sex-Biased, Growth Hormone–Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver (2018) (27)
- Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone (2009) (27)
- A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition (2007) (26)
- Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis. (2013) (26)
- Primary structure of the COOH-terminal membranous segment of a penicillin-sensitive enzyme purified from two Bacilli. (1981) (26)
- Cleavage of a COOH-terminal hydrophobic region from D-alanine carboxypeptidase, a penicillin-sensitive bacterial membrane enzyme. Characterization of active, water-soluble fragments. (1979) (26)
- Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2 (2019) (26)
- Linear, uncross-linked peptidoglycan secreted by penicillin-treated Bacillus subtilis. Isolation and characterization as a substrate for penicillin-sensitive D-alanine carboxypeptidases. (1980) (26)
- Antitumor Activity of Methoxymorpholinyl Doxorubicin: Potentiation by Cytochrome P450 3A Metabolism (2005) (26)
- β-Lactam Antibiotics: Biochemical Modes of Action (1982) (26)
- Interactions of methoxyacetic acid with androgen receptor. (2009) (25)
- Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. (1998) (25)
- Dual E1A Oncolytic Adenovirus: Targeting Tumor Heterogeneity With Two Independent Cancer-specific Promoter Elements, DF3/MUC1 and hTERT (2010) (25)
- Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and immunological identification of a constitutive P450 2B3-like protein in rat liver. (1994) (25)
- Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. (2007) (25)
- Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer (2009) (25)
- Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment (2007) (25)
- Rat hepatic cholesterol 7 alpha-hydroxylase: biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes. (1986) (25)
- Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases. (1993) (25)
- Human telomerase reverse transcriptase promoter-driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions. (2008) (25)
- Participation of two structurally related enzymes in rat hepatic microsomal androstenedione 7 alpha-hydroxylation. (1990) (24)
- Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2 (2014) (22)
- DNase I digestion of isolated nulcei for genome-wide mapping of DNase hypersensitivity sites in chromatin. (2013) (22)
- Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. (1998) (22)
- Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy (2003) (21)
- Impact of Tumor Vascularity on Responsiveness to Antiangiogenesis in a Prostate Cancer Stem Cell-Derived Tumor Model (2013) (21)
- Growth hormone, but not prolactin, maintains, low-level activation of STAT5a and STAT5b in female rat liver. (1999) (21)
- Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver (2019) (21)
- MUTATIONS OUTSIDE OF THE ACTIVE SITE ENHANCE THE METABOLISM OF SEVERAL SUBSTRATES, INCLUDING THE ANTICANCER PRODRUGS CYCLOPHOSPHAMIDE AND IFOSFAMIDE* (2005) (21)
- MAnorm2 for quantitatively comparing groups of ChIP-seq samples (2020) (21)
- Determination of CYP2C9-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography. (2006) (21)
- Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. (2006) (21)
- Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO) (2017) (20)
- Hormonal Regulation of Liver Cytochrome P450 Enzymes (2015) (20)
- Loss of growth hormone–mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity (2019) (20)
- High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations. (1999) (20)
- Microheterogeneity of a male-specific rat hepatic cytochrome P-450: existence of three allozymic forms. (1985) (19)
- Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 2: early spectral changes during apoptosis are linked to apoptotic volume decrease. (2011) (19)
- Hormonal perturbations in patients with testicular cancer treated with cisplatin (1992) (19)
- P450-catalyzed steroid hydroxylation: assay and product identification by thin-layer chromatography. (1991) (19)
- Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures. (2011) (19)
- 3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4. (1986) (19)
- Post-transcriptional regulation of hepatic NADPH-cytochrome P450 reductase by thyroid hormone: independent effects on poly(A) tail length and mRNA stability. (2002) (19)
- Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model (2007) (19)
- Secondary structure relations between beta-lactamases and penicillin-sensitive D-alanine-carboxypeptidases. (2009) (19)
- Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids. (1991) (18)
- Scavenging of hypochlorous acid by lipoic acid (1991) (18)
- Cephalosporin-sensitive penicillin-binding proteins of Staphylococcus aureus and Bacillus subtilis active in the conversion of [14C]penicillin G to [14C]phenylacetylglycine. (1979) (18)
- Penicillin is an active-site inhibitor for four genera of bacteria (1982) (18)
- Early programing of uterine tissue by bisphenol A: Critical evaluation of evidence from animal exposure studies. (2015) (18)
- Purification and characterization of the human neutrophil NADH-cytochrome b5 reductase. (1985) (18)
- Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. (1987) (17)
- Impact of methoxyacetic acid on mouse Leydig cell gene expression (2010) (17)
- Progress and prospects: gene therapy clinical trials (part 1) (2007) (17)
- Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro. (1987) (17)
- Cimetidine prevents alcoholic hepatic injury in the intragastric feeding rat model. (1994) (17)
- Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts (2015) (16)
- Interaction of penicillin with its receptors in bacterial membranes (1980) (16)
- Complex modulation of androgen responsive gene expression by methoxyacetic acid (2011) (16)
- The induction of atherogenic dyslipidaemia in poloxamer 407‐treated mice is not mediated through PPARα (2008) (16)
- CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection. (2006) (16)
- Transcriptional induction of hepatic NADPH: cytochrome P450 oxidoreductase by thyroid hormone. (2001) (15)
- Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6–8 May 2016, Mumbai (2016) (15)
- Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. (1995) (14)
- Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol. (1990) (14)
- Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility (2018) (14)
- Limited proteolysis of the penicillin-sensitive D-alanine carboxypeptidase purified from Bacillus subtilis membranes. Active water-soluble fragments generated by cleavage of a COOH-terminal membrane anchor. (1981) (13)
- Cytochrome P-450 cholesterol 7 alpha-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors. (1987) (13)
- Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+ (2010) (13)
- Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer (2004) (13)
- Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1). (1989) (13)
- Growth Hormone (GH) (2003) (13)
- Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy (2006) (12)
- Mouse lung CYP 1 A 1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo [ 4 , 5b ] pyridine ( PhIP ) (2007) (12)
- Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. (1987) (12)
- Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. (1989) (12)
- High-molecular-weight penicillin-binding proteins from membranes of bacilli (1981) (12)
- Pregnane X receptor-mediated transcription. (2005) (12)
- Interactions of Endocrine-active environmental chemicals with the nuclear receptor PXR (2005) (12)
- Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance (2019) (12)
- Adenoviral vectors for prodrug activation-based gene therapy for cancer. (2014) (12)
- P450 phosphorylation in isolated hepatocytes and in vivo. (1991) (12)
- Impact of Tumor Blood Flow Modulation on Tumor Sensitivity to the Bioreductive Drug Banoxantrone (2013) (11)
- CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection. (1998) (11)
- Growth Hormone Action (2000) (11)
- Evaluation of thyroid hormone effects on liver P450 reductase translation. (2003) (11)
- Cytochrome p450-based gene therapies for cancer. (2004) (11)
- Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice. (2008) (11)
- Catalytic assays for human cytochrome P450: an introduction. (2006) (11)
- Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver (2020) (10)
- High-Performance Liquid Chromatography Analysis of CYP2C8-Catalyzed Paclitaxel 6α-Hydroxylation. (2006) (10)
- STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes (2020) (10)
- Isolation of nuclei for use in genome-wide DNase hypersensitivity assays to probe chromatin structure. (2013) (10)
- Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. (2006) (10)
- Catalytic assays for human cytochrome P450. (1998) (10)
- Amino acid sequence homologies between Escherichia coli penicillin‐binding protein 5 and class a β‐lactamases (1982) (10)
- Determination of CYP2C9-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography. (1998) (10)
- Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells. (2010) (10)
- MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets (2012) (10)
- Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice (2020) (9)
- Influence of lipophilicity and carboxyl group content on the rate of hydroxylation of methotrexate derivatives by aldehyde oxidase. (1990) (9)
- Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. (1989) (8)
- 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levels. (1994) (8)
- Cytochrome P450 2B1 Mediates Complement-dependent Sublytic Injury in a Model of Membranous Nephropathy* (2010) (7)
- Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection. (2006) (7)
- Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450. (1993) (7)
- upon STAT5b: STAT5b-dependent Activation of Male Genes and Repression of Female Genes Revealed by Microarray Analysis * (2006) (7)
- Global analysis of expression, maturation and subcellular localization of mouse liver transcriptome identifies novel sex-biased and TCPOBOP-responsive long non-coding RNAs (2021) (7)
- Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs. (1987) (7)
- Dehydroepiandrosterone Sulfate and-Cell Function Enhanced Glucose-Induced Insulin Secretion and Altered Gene Expression in Rodent Pancreatic-Cells (2000) (7)
- Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver (2019) (6)
- Monoclonal antibodies to rat liver microsomal cytochrome b5. (1992) (6)
- Sex Differences in Drug Metabolism (2012) (6)
- H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity. (2014) (6)
- CTCF and Cohesin link sex-biased distal regulatory elements to sex-biased gene expression in mouse liver (2019) (5)
- Genes for Cancer Therapy System to Enhance Delivery of P 450 Prodrug-Activation Use of Replication-Conditional Adenovirus as a Helper Updated (2004) (5)
- Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR. (2019) (5)
- Steroid Hormones and other Physiologic Regulators of Liver Cytochromes P450: Metabolic Reactions and Regulatory Pathways (1996) (5)
- Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450. (1986) (5)
- Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer (2021) (4)
- High-performance liquid chromatographic analysis of CYP2C8-catalyzed paclitaxel 6 alpha-hydroxylation. (1998) (4)
- Enzymic and chemical reduction of 2-deaminoactinomycins to free radicals. (1985) (4)
- Synergistic Action of Hepatocyte Nuclear Factors 3 and 6 onCYP2C12 Gene Expression and Suppression by Growth Hormone-activated STAT5b (2000) (4)
- Potentiation of Cytochrome P 450 / Cyclophosphamide-based Cancer Gene Therapy by Coexpression of the P 450 Reductase Gene 1 (2006) (4)
- Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model (2021) (4)
- hTERT-promoter driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions (2008) (4)
- CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection. (1998) (3)
- Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. (2006) (3)
- Interplay between GH-regulated, sex-biased liver transcriptome and hepatic zonation revealed by single nucleus RNAseq. (2022) (3)
- Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma (2016) (3)
- Thin-Layer Chromatography Analysis of Human CYP3A-Catalyzed Testosterone 6β-Hydroxylation. (2006) (3)
- Determination of the CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes. (1998) (3)
- Metabolism in Male and Female Rats Differentially Alter Hepatic Drug and Steroid Hormone Platinum Anticancer Drugs Modulate P-450 mRNA Levels and Updated (2006) (3)
- Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood (2012) (3)
- Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress (2019) (3)
- Construction of p450-expressing tumor cell lines using retroviruses. (2000) (3)
- Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes. (2006) (3)
- Regulatory role of growth hormone (2004) (2)
- Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression (2012) (2)
- Constitutively active STAT5b feminizes mouse liver gene expression (2022) (2)
- High-performance liquid chromatography analysis of CYP2C8-catalyzed paclitaxel 6alpha-hydroxylation. (2006) (2)
- Amino acid sequence homologies between Escherichia coli penicillin-binding protein 5 and class A beta-lactamases. (1982) (2)
- Author response: Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver (2018) (2)
- Correction: Chemical and Hormonal Effects on STAT5b- Dependent Sexual Dimorphism of the Liver Transcriptome (2016) (2)
- Impact of neonatal activation of nuclear receptor CAR (Nr1i3) on Cyp2 gene expression in adult mouse liver. (2022) (2)
- Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT (2011) (2)
- HUMAN GENETICS ’ 99 : SEXUAL DEVELOPMENT STAT 5 Signaling in Sexually Dimorphic Gene Expression and Growth Patterns (1999) (2)
- Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model (2022) (1)
- Insulation of gene expression by CTCF and cohesin-based subTAD (ubiquitous intra-TAD) loop structures in mouse liver (2018) (1)
- Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2 (2014) (1)
- Thin-layer chromatography analysis of human CYP3A-catalyzed testosterone 6beta-hydroxylation. (2006) (1)
- Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver (2022) (1)
- STUDIES ON THE CHIRALITY OF SULFOXIDATION CATALYZED BY BACTERIAL FLAVOENZYME ADENINE DINUCLEOTIDE CONTAINING MONOOXYGENASE (1982) (1)
- Abstract 1379: Impact of tumor blood flow modulation on sensitivity of 9L gliosarcoma xenografts to the bioreductive drug, AQ4N (2010) (1)
- Interplay between murine sex-biased gene expression and hepatic zonation revealed by single nucleus RNA sequencing (2022) (1)
- Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine triple-negative breast cancer (2021) (1)
- Constitutively active STAT5b feminizes mouse liver gene expression. (2022) (1)
- Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy. (2000) (1)
- Regulation of Human CYP 2 C 18 and CYP 2 C 19 in Transgenic Mice : Influence of Castration , Testosterone , and Growth Hormone (2009) (1)
- Abstract A80: Metronomic cyclophosphamide induces macrophage recruitment in regressing human and rat gliosarcoma xenografts (2009) (1)
- Type-I Interferon Signaling Is Essential for Robust Metronomic Chemo-Immunogenic Tumor Regression in Murine Breast Cancer (2022) (1)
- Optical scattering serves as a prognostic biomarker for immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model (2022) (0)
- Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts (2015) (0)
- Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection. (1998) (0)
- High-Performance Liquid Chromatographic Analysis of CYP2CSCatalyzed Paclitaxel 6α-Hydroxylation (1998) (0)
- 8 tumor models for evaluation of p450 gene therapy in vivo. (2000) (0)
- Regulation of mouse liver chromatin accessibility and associated early gene responses by CAR (2015) (0)
- Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver (2019) (0)
- Symposium Report CANCER CHEMOTHERAPY AND DRUG METABOLISM (2005) (0)
- Metabolic Activation of Anticancer Oxazaphosphorines by Cytochrome P450s: Development of a Model for Cancer Gene Therapy (1994) (0)
- Influence of Castration, Testosterone and Growth Hormone (2009) (0)
- ROLE OF STATS IN THE BIOLOGICAL FUNCTIONS OF GROWTH HORMONE (2003) (0)
- Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury (2023) (0)
- Catalytic Assays for Human Cytochrome P450 : An Introduction. (2006) (0)
- An isocratic high-performance liquid chromatographic assay for CYP7A1-catalyzed cholesterol 7 alpha-hydroxylation. (1998) (0)
- Towards in vivo preclinical monitoring of multiscale vascular structure-function relationships in resistant breast cancers with an integrated diffuse and nonlinear imaging system (Conference Presentation) (2019) (0)
- Activation of PPAR (cid:1) and PPAR (cid:2) by Environmental Phthalate Monoesters (2003) (0)
- Hepatic P450 Enzymes and Modulation of Drug Metabolism and Clearance in Vivo by P450-inducing Agents1 (2006) (0)
- Global analysis of expression, maturation and subcellular localization of mouse liver transcriptome identifies novel sex-biased and TCPOBOP-responsive long non-coding RNAs (2021) (0)
- An Isocratic High-Performance Liquid Chromatography Assay for CYP7A1-Catalyzed Cholesterol 7α-Hydroxylation. (2006) (0)
- Abstract A87: Metronomic chemotherapy activates innate immunity-induced tumor regression. (2013) (0)
- Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver (2022) (0)
- Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators (2016) (0)
- PL1 Genomic approaches to unraveling the complexity of GH-regulated liver sex differences (2010) (0)
- Glutathione 5-Transferases: Role in Alkylating Agent Resistance and Possible Target for Modulation Chemotherapy— A Review1 (2006) (0)
- Abstract B121: Low dose, metronomic cyclophosphamide therapy sensitizes tumors to CpG-1826 immunotherapy in a preclinical glioma model (2016) (0)
- An Isocratic High-Performance Liquid Chromatographic Assay for CYP7Al-Catalyzed Cholesterol 7α-Hyciroxylation (1998) (0)
- Sexual Dimorphism of Liver Cytochrome P-450 Gene Expression: GH Pulse-Activated STAT Signaling Mechanisms (1999) (0)
- Sex-biased long non-coding RNAs negatively correlated with sex-opposite protein coding gene co-expression networks in Diversity Outbred mouse liver (2018) (0)
- Nuclear Receptor Regulation of Hepatic Cytochrome P450 Enzymes (2020) (0)
- 7 in vitro methods for evaluation of p450-based anticancer gene therapy. (2000) (0)
- Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver (2020) (0)
- TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule (2023) (0)
- Drug-Receptor Interactions: The Example of β-Lactam Antibiotics* (1979) (0)
- Activators of CAR and PXR Rapidly Alter Chromatin Accessibility in Mouse Liver (2013) (0)
- CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection. (2006) (0)
- Diffuse and Nonlinear Imaging for In Vivo Monitoring of Tumor Vascular Structure and Function (2020) (0)
- Biotransformation Oxidative Desulfuration to Yield Ar,A^',Ar"-Triethylenephosphoramide Associated with Suicide Inactivation of a Phenobarbital-inducible Hepatic P-450 Monooxygenase1 (2006) (0)
- Repression of cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl (HCB), 3-methylcholanthrene (3-MC) and phenobarbital (PB) in livers from male rats (1986) (0)
- Thin-layer chromatographic analysis of human CYP3A-catalyzed testosterone 6 beta-hydroxylation. (1998) (0)
- Dysregulation of murine long non-coding single cell transcriptome in non-alcoholic steatohepatitis and liver fibrosis (2022) (0)
- 4 Metabolie Aetivation ot Anticancer Oxazaphosphorines by Cytoehrome P450s: Development ot a Model tor Cancer Gene Therapy (1994) (0)
- The lithocholic acid 6f1-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6fl-hydroxylation (2005) (0)
- Regulation of P450-dependent hepatic steroid hydroxylation by growth hormone and thyroxine (1992) (0)
- trans -Activation of PPAR a and Induction of PPAR a Target Genes by Perfluorooctane-Based Chemicals (2004) (0)
- Sex matters in liver fat regulation (2022) (0)
- A novel drug-sensitivity gene, cytochrome P450 2B1, activates cyclophosphamide (1995) (0)
- Abstract 3813: Recruitment of macrophages, NK cells, and dendritic cells with metronomic cyclophosphamide-induced regression of gliosarcoma xenografts (2010) (0)
- An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7alpha-hydroxylation. (2006) (0)
- Impact of neonatal activation of nuclear receptor CAR (Nr1i3) on Cyp2 gene expression in adult mouse liver (2022) (0)
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