David Julius
#11,162
Most Influential Person Now
American physiologist and Nobel laureate 2021
David Julius's AcademicInfluence.com Rankings
David Juliusbiology Degrees
Biology
#695
World Rank
#1216
Historical Rank
#386
USA Rank
Physiology
#22
World Rank
#81
Historical Rank
#8
USA Rank
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Biology
David Julius's Degrees
- PhD Biochemistry University of California, Berkeley
Why Is David Julius Influential?
(Suggest an Edit or Addition)According to Wikipedia, David Jay Julius is an American physiologist and Nobel Prize laureate known for his work on molecular mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor at the University of California, San Francisco.
David Julius's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The capsaicin receptor: a heat-activated ion channel in the pain pathway (1997) (8121)
- Impaired nociception and pain sensation in mice lacking the capsaicin receptor. (2000) (3329)
- Cellular and Molecular Mechanisms of Pain (2009) (3217)
- The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli (1998) (2936)
- Molecular mechanisms of nociception (2001) (2406)
- Identification of a cold receptor reveals a general role for TRP channels in thermosensation (2002) (2284)
- Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide (1999) (2126)
- Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 (2004) (1784)
- TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents (2006) (1759)
- A capsaicin-receptor homologue with a high threshold for noxious heat (1999) (1491)
- The vanilloid receptor: a molecular gateway to the pain pathway. (2001) (1490)
- Identification of the platelet ADP receptor targeted by antithrombotic drugs (2001) (1454)
- Structure of the TRPV1 ion channel determined by electron cryo-microscopy (2013) (1368)
- Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors (1995) (1278)
- Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition (2001) (1270)
- The P2Y12 receptor regulates microglial activation by extracellular nucleotides (2006) (1180)
- TRPA1 mediates formalin-induced pain (2007) (1122)
- The menthol receptor TRPM8 is the principal detector of environmental cold (2007) (1122)
- Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. (1991) (948)
- New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor (1994) (943)
- Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers (2002) (847)
- TRP channel activation by reversible covalent modification (2006) (811)
- Pungent products from garlic activate the sensory ion channel TRPA1. (2005) (784)
- 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 (2007) (703)
- Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. (1988) (644)
- Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor (1984) (628)
- Substitution of three amino acids switches receptor specificity of Gqα to that of Giα (1993) (617)
- TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action (2016) (613)
- Acid potentiation of the capsaicin receptor determined by a key extracellular site. (2000) (604)
- A unified nomenclature for the superfamily of TRP cation channels. (2002) (603)
- TRP channels and pain. (2013) (573)
- Expression cloning of an ATP receptor from mouse neuroblastoma cells. (1993) (572)
- TRPV1 structures in distinct conformations reveal mechanisms of activation (2013) (561)
- A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity (2003) (551)
- Structure of the TRPA1 ion channel suggests regulatory mechanisms (2015) (515)
- Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways (2017) (463)
- Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells (2011) (439)
- International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels (2005) (382)
- The 5-HT3 Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors (2002) (380)
- Nervous system distribution of the serotonin 5-HT3 receptor mRNA. (1993) (372)
- Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase (1983) (370)
- Molecular Basis of Infrared Detection by Snakes (2010) (354)
- Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. (1989) (348)
- Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain (2005) (336)
- Glycosylation and processing of prepro-α-factor through the yeast secretory pathway (1984) (335)
- Lessons from peppers and peppermint: the molecular logic of thermosensation (2003) (326)
- The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel (2004) (304)
- Spider toxins activate the capsaicin receptor to produce inflammatory pain (2006) (300)
- A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain (2011) (295)
- The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. (1990) (275)
- A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain (2010) (263)
- TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids (2013) (261)
- The anandamide transport inhibitor AM404 activates vanilloid receptors. (2000) (257)
- 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. (1989) (254)
- X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel (2014) (241)
- International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels (2003) (241)
- Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons (2011) (218)
- Selective spider toxins reveal a role for Nav1.1 channel in mechanical pain (2016) (215)
- Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels (2008) (203)
- Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli (2011) (200)
- Structure of the human TRPM4 ion channel in a lipid nanodisc (2018) (193)
- Sense and specificity: a molecular identity for nociceptors (1999) (193)
- Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats (2011) (191)
- Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. (1993) (191)
- Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. (1999) (181)
- Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function (2008) (173)
- Posttraumatic stress disorder: clinical features, pathophysiology, and treatment. (2006) (169)
- ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor (2001) (153)
- Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A−/−, 5-HT1B−/−, 5-HT2A−/−, 5-HT3A−/− and 5-HTT−/− knock-out male mice (2007) (145)
- Molecular biology of serotonin receptors. (1991) (143)
- Coiled Coils Direct Assembly of a Cold-Activated TRP Channel (2006) (131)
- A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating (2008) (122)
- Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails. (1998) (113)
- Immunoreactive TRPV‐2 (VRL‐1), a capsaicin receptor homolog, in the spinal cord of the rat (2004) (99)
- Structural insights into TRPM8 inhibition and desensitization (2019) (95)
- Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons (2008) (91)
- Capsaicin receptor in the pain pathway. (2000) (88)
- Trpv 1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells (2015) (78)
- Structure of the TRPA1 ion channel suggests regulatory mechanisms (2015) (78)
- Posttraumatic stress disorder as a risk factor for obesity among male military veterans (2007) (77)
- Single particle electron cryo-microscopy of a mammalian ion channel. (2014) (73)
- Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4). (1992) (71)
- Evolution of Thermal Response Properties in a Cold-Activated TRP Channel (2009) (69)
- Molecular basis of ancestral vertebrate electroreception (2017) (68)
- Co‐localization of endomorphin‐2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat (2004) (67)
- The serotonin receptor subtype 2 locusHTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14 (1990) (66)
- Signaling by sensory receptors. (2012) (65)
- Irritant-evoked activation and calcium modulation of the TRPA1 receptor (2020) (63)
- Expression of a Serotonin-Gated Ion Channel in Embryonic Neural and Nonneural Tissues (1995) (62)
- Structural insight into TRPV5 channel function and modulation (2018) (61)
- Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. (1984) (59)
- A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence (1983) (56)
- Posttraumatic stress disorder in male military veterans with comorbid overweight and obesity: psychotropic, antihypertensive, and metabolic medications. (2006) (55)
- Receptor-targeting mechanisms of pain-causing toxins: How ow? (2012) (55)
- A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain (2019) (54)
- Structural snapshots of TRPV1 reveal mechanism of polymodal functionality (2021) (52)
- Serotonin receptor knockouts: a moody subject. (1998) (42)
- Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment. (2019) (41)
- Effect of clonidine and yohimbine on sleep in healthy men: a double-blind, randomized, controlled trial (1996) (40)
- Neuronal Expression of the 5HT3 Serotonin Receptor Gene Requires Nuclear Factor 1 Complexes (1998) (38)
- Fire in the hole: pore dilation of the capsaicin receptor TRPV1 (2008) (37)
- Cellular and molecular properties of primary afferent neurons (2006) (37)
- A new wave of serotonin receptors (1993) (36)
- Toward better pain control. (2006) (36)
- Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse (2006) (35)
- Psychodynamics of Drug Dependence (1977) (34)
- Posttraumatic stress disorder and body mass index in military veterans Preliminary findings (2006) (33)
- Molecular tuning of electroreception in sharks and skates (2018) (32)
- Uropathic Observations in Mice Expressing a Constitutively Active Point Mutation in the 5-HT3A Receptor Subunit (2004) (31)
- Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release (2017) (31)
- Treatment of depression in patients with coronary heart disease. (2006) (25)
- From peppers to peppermints: natural products as probes of the pain pathway. (2005) (23)
- Home for an orphan endorphin (1995) (22)
- Multiple Unbiased Prospective Screens Identify TRP Channels and Their Conserved Gating Elements (2008) (21)
- Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes (2017) (21)
- Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch (2018) (21)
- Body mass index relates to males with posttraumatic stress disorder. (2006) (20)
- NIDA's naltrexone research program. (1976) (19)
- Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole. (2006) (18)
- ATP receptors in sickness, pain and death. (1996) (17)
- Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype. (1992) (16)
- Functional expression of the 5-HT1c receptor in neuronal and nonneuronal cells. (1988) (16)
- Another opiate for the masses? (1997) (13)
- Maprotiline Hydrochloride Associated with a Clinical State of Catatonic Stupor and Epileptic Encephalogram (1984) (12)
- Research and development of naltrexone: a new narcotic antagonist. (1979) (11)
- TRP Channel Structural Biology: New Roles for an Old Fold (2007) (10)
- A Nobel for Smell (2004) (10)
- A Neuropeptide Courier for δ-Opioid Receptors? (2005) (9)
- Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (8)
- Sensory TRP Channels in Three Dimensions. (2022) (7)
- Structure of acid-sensing ion channel in complex with snake toxin (2014) (7)
- Psychodynamics of Drug Dependence. NIDA Research Monograph 12. (1977) (7)
- Neurobiology 5-HT 1 c receptor is a prominent serotonin receptor subtype in the central nervous system ( 5-HTlc receptor / serotonin / in situ hybridizadon / central nervous system / neurotransmission ) (7)
- Pharmacology. Home for an orphan endorphin. (1995) (7)
- Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1 (2019) (7)
- Electrosensory Transduction: Comparisons Across Structure, Afferent Response Properties, and Cellular Physiology (2019) (6)
- A neuropeptide courier for delta-opioid receptors? (2005) (5)
- Unofficial diplomacy at work (1991) (5)
- Parasomnias: Sleepwalking, Night Terrors, and Nightmares (1987) (4)
- Narcotic Antagonists: Naltrexone Progress Report: NIDA Research Monograph 9: (497452006-001) (1976) (4)
- Molecular biology of pituitary development and disease. (1996) (3)
- Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Subject Collection Signal Transduction The Hippo Pathway (2012) (3)
- Posttraumatic Stress Disorder and Body Mass Index in Military Veterans: The Richmond Experience (2006) (3)
- Biculturalism and International Interdependence (1985) (2)
- Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy (2013) (2)
- Ion Channel in Lipid Nanodisc By Single Particle Cryo-EM - Pushing The Technology Limit (2017) (2)
- Concepts and theories (1990) (2)
- TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons (2022) (2)
- Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state (2019) (2)
- Editorial overview: Molecular biology of sensation (2015) (2)
- Molecular determinants of ligand interaction with the capsaicin receptor (2003) (1)
- TRP'S Sensational Pathways: Unlocking Mysteries of Pain & Temperature (2011) (1)
- Structure of TRPV1 determined in lipid nanodisc (2016) (1)
- Lacking the Capsaicin Receptor Impaired Nociception and Pain Sensation in Mice (2007) (1)
- Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3 (2021) (1)
- Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy (2013) (1)
- Irritant-evoked activation and calcium modulation of the TRPA1 receptor (2020) (1)
- カプサイシン受容体：熱・プロトンで活性化されるイオンチャネル (1999) (1)
- Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state (2019) (0)
- A Novel Toxin that Targets Acid-Sensing Ion Channels to Produce Pain (2012) (0)
- Cold- and menthol-sensitive receptor (CMR1) (2016) (0)
- Cryo-EM structure of minimal TRPV1 with 4 partially bound RTX (2021) (0)
- Wasabi Receptor Toxin (2019) (0)
- MAMMALLAN CELLS EXPRESSING SAME AND USES THEREOF (2017) (0)
- ContributionofthePutativeInner-PoreRegiontotheGating oftheTransientReceptorPotentialVanilloidSubtype1 Channel(TRPV1) (2007) (0)
- Cryo-EM structure of minimal TRPV1 with 3 bound RTX and 1 perturbed PI (2021) (0)
- Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state (2017) (0)
- CHARACTERIZATION OF COLD SENSITIVE CELLS IN THE HYPOTHALAMUS.: 433 (2004) (0)
- Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state (2021) (0)
- Stephen F. Heinemann: A true original (2014) (0)
- Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1 (2022) (0)
- High-Resolution Cryo-EM Structures of TRPV1 Reveal Structural Basis of Ligand Binding and Channel Gating (2016) (0)
- Cryo-EM structure of TRPV5 W583A in nanodisc (2019) (0)
- REINING IN PAIN (2006) (0)
- 433 CHARACTERIZATION OF COLD SENSITIVE CELLS IN THE HYPOTHALAMUS. (2004) (0)
- cryo-EM structure of DkTx-bound minimal TRPV1 in open state (2021) (0)
- Cryo-EM structure of minimal TRPV1 with 1 perturbed PI (2021) (0)
- Molecular tuning of electroreception in sharks and skates (2018) (0)
- Gut enterochromaffin cells drive visceral pain and anxiety (2023) (0)
- A comprehensive psychiatric approach to drug dependence. (1981) (0)
- Historical trends in naltrexone research. (1978) (0)
- Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG (2020) (0)
- Psychodynamics of drug deependence: introduction. (1977) (0)
- Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state (2019) (0)
- Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc (2016) (0)
- Cryo-EM structure of unliganded full-length TRPV1 at neutral pH (2021) (0)
- Identification of a Domain in Trpv4 C-Terminus Critical for Channel Function and Trafficking (2013) (0)
- A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM (2022) (0)
- Withdrawal from endogenous opiates. (1979) (0)
- SPARC ‐ Mapping Gut‐Spinal Cord Connections in Visceral Pain (2020) (0)
- Disruption of the vanilloid receptor 1 gene impairs the responses of sensory neurons to protons (2000) (0)
- Cryo-EM structure of RTX-bound full-length TRPV1 at pH 5.5 (2021) (0)
- Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state (2019) (0)
- Cryo-EM structure of DkTx/RTX-bound full-length TRPV1 (2021) (0)
- Cryo-EM structure of TRPV5 with calmodulin bound (2019) (0)
- Mechanisms of Neuronal Cell Fate Specification and Neuronal Morphogenesis (2017) (0)
- Cryo-EM structure of minimal TRPV1 with 2 bound RTX in opposite pockets (2021) (0)
- Structure of a membrane protein (2014) (0)
- Cryo-EM structure of full-length TRPV1 at pH6a state (2021) (0)
- Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety (2022) (0)
- Cryo-EM structure of minimal TRPV1 with 1 partially bound RTX (2021) (0)
- Acculturation Stress of Americans Overseas (1985) (0)
- Structure of TRPA1 (ligand-free) with bound calcium, LMNG (2020) (0)
- Cryo-EM structure of full length TRPV5 in nanodisc (2019) (0)
- Cryo-EM structure of TRPV5 (1-660) in nanodisc (2019) (0)
- cryo-EM structure of unliganded minimal TRPV1 (2021) (0)
- Structure of acid-sensing ion channel in complex with snake toxin and amiloride (2014) (0)
- AFM imaging reveals the assembly of a P 2 X receptor complex containing P 2 X 2 , P 2 X 4 and P 2 X 6 subunits (2013) (0)
- Neuron Reports (2003) (0)
- Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy (2013) (0)
- Structure of TRPA1 modified by iodoacetamide, PMAL-C8 (2020) (0)
- cryo-EM structure of DkTx-bound minimal TRPV1 in partial open state (2021) (0)
- Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin (2014) (0)
- Cryo-EM structure of RTX-bound full-length TRPV1 in C1 state (2021) (0)
- cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state a (2021) (0)
- Using Spider Venom Peptides as Molecular Tools for Understanding Voltage-Gated Sodium Channel Function (2016) (0)
- Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc (2016) (0)
- A Novel Tarantula Toxin Irreversibly Activates TRPV1 (2010) (0)
- Cryo-EM structure of minimal TRPV1 with RTX bound in C1 state (2021) (0)
- cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state (2021) (0)
- Procedes de modulation de la perception du froid (2003) (0)
- Structure of TRPA1 bound with A-967079, PMAL-C8 (2020) (0)
- Cryo-EM structure of minimal TRPV1 with RTX bound in C2 state (2021) (0)
- Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets (2021) (0)
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