David Kimelman
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Molecular Biology
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Biology
David Kimelman's Degrees
- PhD Neuroscience University of California, Berkeley
- Masters Biology Stanford University
- Bachelors Biochemistry University of California, Berkeley
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(Suggest an Edit or Addition)David Kimelman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. (1996) (1234)
- Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo (1987) (873)
- β-Catenin destruction complex: insights and questions from a structural perspective (2006) (621)
- A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. (1997) (563)
- A homeobox gene essential for zebrafish notochord development (1995) (480)
- Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal (2000) (455)
- Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1 (1999) (432)
- Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway (1997) (421)
- Crystal Structure of a β-Catenin/Tcf Complex (2000) (375)
- The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer. (1988) (360)
- From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus (1998) (349)
- Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. (1998) (347)
- GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis (1998) (344)
- The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle (1987) (329)
- An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes (1989) (289)
- XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. (1999) (263)
- Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. (1995) (246)
- Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. (2003) (243)
- Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. (1995) (237)
- Mechanistic insights from structural studies of β-catenin and its binding partners (2007) (235)
- Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. (1993) (233)
- Activin-mediated mesoderm induction requires FGF. (1994) (231)
- A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. (2002) (222)
- Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction. (1992) (215)
- Mesoderm induction: from caps to chips (2006) (210)
- Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation. (2012) (206)
- Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation. (2008) (202)
- E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related (1985) (189)
- Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification (2000) (173)
- Wnt Signaling and the Evolution of Embryonic Posterior Development (2009) (168)
- Vertebrate mesendoderm induction and patterning. (2000) (167)
- Crystal structure of a beta-catenin/Tcf complex. (2000) (167)
- Crystal Structure of a β-Catenin/BCL9/Tcf4 Complex (2006) (167)
- Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. (2004) (163)
- Local Tissue Interactions across the Dorsal Midline of the Forebrain Establish CNS Laterality (2003) (163)
- Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox. (1996) (161)
- Move it or lose it: axis specification in Xenopus (2004) (159)
- Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta. (2009) (151)
- Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development (2005) (149)
- Activation of Siamois by the Wnt pathway. (1996) (147)
- Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP (2005) (140)
- FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction. (1995) (128)
- The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. (2002) (126)
- Brachyury establishes the embryonic mesodermal progenitor niche. (2010) (123)
- Calculation of protein tertiary structure. (1976) (122)
- Tcf4 can specifically recognize β-catenin using alternative conformations (2001) (121)
- The role of the yolk syncytial layer in germ layer patterning in zebrafish. (2000) (120)
- The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. (2001) (119)
- Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. (2000) (110)
- A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos (1997) (107)
- Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. (2000) (104)
- The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development. (1994) (104)
- HrT is required for cardiovascular development in zebrafish. (2002) (96)
- Sustained Bmp signaling is essential for cloaca development in zebrafish (2006) (92)
- Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations (2004) (90)
- Expression of the human fibroblast interferon gene in Escherichia coli. (1980) (89)
- Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation (2004) (88)
- TheXenopus laevis homeo☐ geneXgbx-2 is an early marker of anteroposterior patterning in the ectoderm (1996) (88)
- Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish. (2005) (88)
- v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis. (1993) (87)
- A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. (2000) (86)
- Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning. (1995) (84)
- Dorsal-ventral differences in Xcad-3 expression in response to FGF-mediated induction in Xenopus. (1994) (82)
- Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis (2008) (82)
- One-Eyed Pinhead and Spadetail are essential for heart and somite formation (2002) (78)
- Faculty Opinions recommendation of Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. (2006) (75)
- Tcf4 can specifically recognize beta-catenin using alternative conformations. (2001) (74)
- Rho-regulated Myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation (2009) (73)
- The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. . (2001) (71)
- GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs (2003) (71)
- Crystal structure of a beta-catenin/BCL9/Tcf4 complex. (2006) (68)
- Overlapping expression of zebrafish T-brain-1 and eomesodermin during forebrain development (2001) (68)
- Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation (2012) (68)
- Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation. (2007) (63)
- BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus. (1995) (61)
- Glycogen Synthase Kinase-3β Mutagenesis Identifies a Common Binding Domain for GBP and Axin* (2002) (61)
- Anterior–posterior patterning in early development: three strategies (2012) (60)
- Mesoderm Induction A Postmodern View (1998) (60)
- Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development. (2003) (60)
- Tales of Tails (and Trunks): Forming the Posterior Body in Vertebrate Embryos. (2016) (59)
- Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression (1985) (59)
- Spatial regulation of floating head expression in the developing notochord (1997) (56)
- Restricted expression of cdc25a in the tailbud is essential for formation of the zebrafish posterior body (2014) (56)
- Transdifferentiation of Fast Skeletal Muscle Into Functional Endothelium in Vivo by Transcription Factor Etv2 (2013) (54)
- Specification of the Primitive Myeloid Precursor Pool Requires Signaling through Alk8 in Zebrafish (2006) (53)
- The regulation of mesodermal progenitor cell commitment to somitogenesis subdivides the zebrafish body musculature into distinct domains. (2006) (53)
- Induction of dorsal and ventral mesoderm by ectopically expressed Xenopus basic fibroblast growth factor. (1992) (52)
- Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox. (1999) (51)
- Laminin α5 is essential for the formation of the zebrafish fins (2007) (49)
- Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development. (1994) (49)
- Overexpression of Xgsk-3 disrupts anterior ectodermal patterning in Xenopus. (1996) (48)
- Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo (2016) (47)
- Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm (2015) (47)
- Cdc25 and the importance of G2 control (2014) (46)
- Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud. (2009) (45)
- Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish (1999) (42)
- Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic β-cells in zebrafish (2009) (42)
- Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail. (2011) (42)
- psoriasis regulates epidermal development in zebrafish (2008) (41)
- Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors. (2015) (37)
- Fibroblast growth factor, but not activin, is a potent activator of mitogen-activated protein kinase in Xenopus explants. (1994) (36)
- Faculty Opinions recommendation of Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm. (2006) (35)
- Crystal structure of a -catenin/Axin complex suggests a mechanism for the -catenin destruction complex (2003) (35)
- COUP-TFI is a potential regulator of retinoic acid-modulated development in Xenopus embryos (1995) (33)
- A targeted gene expression system using the tryptophan repressor in zebrafish shows no silencing in subsequent generations (2014) (30)
- Laminin alpha5 is essential for the formation of the zebrafish fins. (2007) (29)
- Dual fucci: a new transgenic line for studying the cell cycle from embryos to adults. (2014) (29)
- Cysteine Repeat Domains and Adjacent Sequences Determine Distinct Bone Morphogenetic Protein Modulatory Activities of the Drosophila Sog Protein (2004) (28)
- Interactions between Casein Kinase Iε (CKIε) and Two Substrates from Disparate Signaling Pathways Reveal Mechanisms for Substrate-Kinase Specificity (2009) (27)
- Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1 (2017) (26)
- Faculty Opinions recommendation of Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. (2003) (24)
- Combinatorial signaling in development. (1994) (24)
- Xenopus laevis: a model system for the study of embryonic retinoid metabolism. I. Embryonic metabolism of 9-cis- and all-trans-retinals and retinols to their corresponding acid forms. (1995) (24)
- Production of a monospecific antiserum against the early region 1A proteins of adenovirus 12 and adenovirus 5 by an adenovirus 12 early region 1A-beta-galactosidase fusion protein antigen expressed in bacteria (1984) (20)
- Xenopus laevis: a model system for the study of embryonic retinoid metabolism. II. Embryonic metabolism of all-trans-3,4-didehydroretinol to all-trans-3,4-didehydroretinoic acid. (1995) (20)
- Identification of adenovirus 12-encoded E1A tumor antigens synthesized in infected and transformed mammalian cells and in Escherichia coli (1984) (19)
- Analysis of early epidermal development in zebrafish. (2005) (19)
- LZIC regulates neuronal survival during zebrafish development. (2005) (18)
- Wnt/β-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate (2012) (15)
- Bmp Signaling: Turning a Half into a Whole (2005) (15)
- Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development (2020) (13)
- Alternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development (2010) (12)
- Mesoderm induction and patterning. (2002) (11)
- A novel general approach to eucaryotic mutagenesis functionally identifies conserved regions within the adenovirus 13S E1A polypeptide (1986) (11)
- Analysis of cell shape and polarity during zebrafish gastrulation. (2012) (11)
- Synthesis in Escherichia coli of human adenovirus type 12 transforming proteins encoded by early region 1A 13S mRNA and 12S mRNA. (1984) (10)
- Transcriptional regulation in Xenopus: a bright and froggy future. (1999) (10)
- Peptide growth factors and the regulation of early amphibian development. (1993) (10)
- Identification of in vivo Hox13 binding sites reveals an essential locus controlling zebrafish brachyury expression. (2021) (8)
- A novel cold‐sensitive mutant of ntla reveals temporal roles of brachyury in zebrafish (2016) (8)
- Taking a bite out of Wnts (2012) (7)
- hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. (2020) (6)
- Cell shape regulation by Gravin requires N-terminal membrane effector domains. (2008) (6)
- Wnt signalling gets XEEKy (2003) (5)
- Regulation of eukaryotic gene expression by natural antisense transcripts. The case of the modifying reaction. (1992) (5)
- Chordin cleavage is sizzling (2006) (5)
- Regulation of canonical Wnt signaling by Brachury is essential for posterior mesoderm formation (2008) (4)
- Faculty Opinions recommendation of Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. (2005) (4)
- Squinting at the zebrafish axis. (2006) (4)
- Faculty Opinions recommendation of The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate. (2002) (4)
- Faculty Opinions recommendation of Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (2002) (4)
- Ground, Path, and Fruition: Teaching Zebrafish Development to Tibetan Buddhist Monks in India. (2018) (3)
- Faculty Opinions recommendation of Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (2002) (3)
- Developmental Biology: Micro(RNA)-Managing Nodal (2007) (3)
- Deep molecular, cellular and temporal phenotyping of developmental perturbations at whole organism scale (2022) (3)
- Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression. (2021) (3)
- Welcoming the Stranger: African Refugees and Israel's Asylum Regime (2016) (3)
- SUMMARY verbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol , respectively , in Xenopus embryogenesis (1996) (2)
- Regulation of dorsal-ventral axis formation in Xenopus by intercellular and intracellular signalling. (1996) (2)
- NIEHS/EPA Workshops. Pattern formation. (1997) (2)
- Establishing The Body Plan (2020) (2)
- RAPID COMMUNICATION Activation of Siamois by the Wnt Pathway (1996) (1)
- Rethinking Embryonic Germ Layers (2011) (1)
- On the fast track to organizer gene expression. (2010) (1)
- Spemann organizer formation by the intracellu (1995) (1)
- Proteostasis governs differential temperature sensitivity across embryonic cell types (2022) (1)
- Crystal Structure of the Beta-catenin/ICAT Complex (2002) (1)
- The Role of Fibroblast Growth Factor in Early Xenopus Development (1991) (1)
- Identification ofAdenovirus 12-Encoded ElATumorAntigens Synthesized inInfected andTransformed MammalianCells andin Escherichia coli (1984) (0)
- Beta-catenin binding domain of Axin in complex with beta-catenin (2003) (0)
- CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX (2000) (0)
- Faculty Opinions recommendation of Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. (2003) (0)
- Faculty Opinions recommendation of CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. (2006) (0)
- Slippery slopes: understanding gradients and asymmetries in development (1997) (0)
- Faculty Opinions recommendation of The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. (2007) (0)
- Faculty Opinions recommendation of Complementary roles for dynein and kinesins in the Xenopus egg cortical rotation. (2004) (0)
- Faculty Opinions recommendation of CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. (2006) (0)
- Faculty Opinions recommendation of Live analysis of endodermal layer formation identifies random walk as a novel gastrulation movement. (2008) (0)
- Faculty Opinions recommendation of Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side. (2005) (0)
- Abstracts of the 14th Red Lara Taller General, Mérida, Mexico, 06-9 March 2019 (2019) (0)
- DEVELOPMENT OF THE ZEBRAFISH NOTOCHORD (1995) (0)
- Faculty Opinions recommendation of Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. (2005) (0)
- Faculty Opinions recommendation of Vg 1 is an essential signaling molecule in Xenopus development. (2005) (0)
- Faculty Opinions recommendation of Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt? (2003) (0)
- Myosin Phosphatase controls the level of protrusive activity required for convergent extension during zebrafish gastrulation (2009) (0)
- Faculty Opinions recommendation of Shroom induces apical constriction and is required for hingepoint formation during neural tube closure. (2003) (0)
- Faculty Opinions recommendation of The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm. (2003) (0)
- CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4 (2001) (0)
- Faculty Opinions recommendation of Beta-catenin, MAPK and Smad signaling during early Xenopus development. (2002) (0)
- Wnt signaling controls mesodermal/neural and muscle/vascular stem cell fates during somitogenesis (2011) (0)
- Faculty Opinions recommendation of Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. (2002) (0)
- Crystal structure of a (cid:1) -catenin/Axin complex suggests a mechanism for the (cid:1) -catenin destruction complex (2003) (0)
- Faculty Opinions recommendation of Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. (2005) (0)
- ulation of Spemann organizer formation by the intracellu (0)
- Faculty Opinions recommendation of An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. (2003) (0)
- Faculty Opinions recommendation of Neural and head induction by insulin-like growth factor signals. (2001) (0)
- Faculty Opinions recommendation of Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. (2004) (0)
- Faculty Opinions recommendation of Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. (2007) (0)
- A single-cell transcriptional timelapse of mouse embryonic development, from gastrula to pup (2023) (0)
- Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment (2004) (0)
- Contributors (2021) (0)
- Completion of the epithelial to mesenchymal transition in zebra fi sh mesoderm requires (2011) (0)
- Faculty Opinions recommendation of Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC. (2007) (0)
- Regulation of Wnt expression coordinates vertebrate D/V and A/P axis patterning (2009) (0)
- Faculty Opinions recommendation of Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. (2003) (0)
- Faculty Opinions recommendation of The C. elegans SYS-1 protein is a bona fide beta-catenin. (2008) (0)
- Faculty Opinions recommendation of Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. (2003) (0)
- Faculty Opinions recommendation of Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. (2005) (0)
- Faculty Opinions recommendation of Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. (2003) (0)
- Faculty Opinions recommendation of Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. (2005) (0)
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