David Klenerman

David Klenerman's AcademicInfluence.com Rankings

David Klenerman

Chemistry

#1969

World Rank

#2799

Historical Rank

Organic Chemistry

#853

World Rank

#954

Historical Rank

chemistry Degrees

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Chemistry

Why Is David Klenerman Influential?

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According to Wikipedia, Sir David Klenerman is a British biophysical chemist and a professor of biophysical chemistry at the Department of Chemistry at the University of Cambridge and a Fellow of Christ's College, Cambridge.

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David Klenerman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Accurate Whole Human Genome Sequencing using Reversible Terminator Chemistry (2008) (3580)
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein (2012) (725)
3D structure of individual mammalian genomes studied by single cell Hi-C (2017) (588)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions (2018) (521)
Nanoscale live-cell imaging using hopping probe ion conductance microscopy (2009) (411)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation (2015) (382)
The 2015 super-resolution microscopy roadmap (2015) (300)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018) (283)
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer (2003) (257)
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016) (254)
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide (2011) (241)
Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces. (2011) (227)
Initiation of T cell signaling by CD45 segregation at ‘close-contacts’ (2016) (203)
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence (2008) (190)
A reversible pH-driven DNA nanoswitch array. (2006) (185)
Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. (2006) (181)
Electrochemical nanoprobes for single-cell analysis. (2014) (179)
Ubiquitin chain conformation regulates recognition and activity of interacting proteins (2012) (178)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading (2016) (173)
Direct and sensitive detection of a human virus by rupture event scanning (2001) (169)
Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. (2013) (166)
Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy (2012) (163)
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers (2015) (158)
Quantitative single-molecule microscopy reveals that CENP-ACnp1 deposition occurs during G2 in fission yeast (2012) (155)
Single-molecule visualisation of DNA G-quadruplex formation in live cells (2020) (150)
Dynamic assembly of surface structures in living cells (2003) (149)
Ultrasensitive coincidence fluorescence detection of single DNA molecules. (2003) (144)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms (2019) (144)
α-Synuclein Strains Target Distinct Brain Regions and Cell Types (2019) (144)
Non-Arrhenius kinetics for the loop closure of a DNA hairpin (2001) (144)
Writing with DNA and protein using a nanopipet for controlled delivery. (2002) (140)
Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes. (2001) (139)
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons (2015) (133)
Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. (2004) (132)
Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. (2005) (131)
A compact functional quantum Dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection. (2008) (130)
3 D structure of individual mammalian genomes studied by single cell HiC (2017) (129)
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping (2016) (116)
Trapping of proteins under physiological conditions in a nanopipette. (2005) (116)
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits (2016) (112)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity (2016) (110)
Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette. (2008) (109)
Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. (2002) (109)
Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy (1998) (106)
Mechanistic studies of the corrosion inhibitor oleic imidazoline (1994) (105)
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (100)
Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates (2019) (98)
Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking. (2007) (97)
Lipid peroxidation is essential for α‐synuclein‐induced cell death (2015) (96)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids (2016) (95)
Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. (2003) (91)
Nanoscale-Targeted Patch-Clamp Recordings of Functional Presynaptic Ion Channels (2013) (90)
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants (2015) (89)
The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules. (2005) (89)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis (2018) (89)
Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage (2014) (89)
Nanopore extended field-effect transistor for selective single-molecule biosensing (2017) (88)
Two-component graded deposition of biomolecules with a double-barreled nanopipette. (2005) (88)
Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: Application to single virus-like particle entry into a cell (2002) (85)
An addressable antibody nanoarray produced on a nanostructured surface. (2004) (85)
Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells (2013) (83)
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells (2007) (82)
Kinetics of unfolding the human telomeric DNA quadruplex using a PNA trap. (2003) (82)
Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis. (2016) (81)
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers. (2015) (80)
High‐resolution scanning patch‐clamp: new insights into cell function (2002) (78)
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity (2018) (78)
FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop (2000) (77)
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones. (2012) (77)
Supramolecular organization of the sperm plasma membrane during maturation and capacitation. (2007) (76)
Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet. (2006) (75)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity (2018) (75)
Surface conductivity of biological macromolecules measured by nanopipette dielectrophoresis. (2007) (74)
The use of scanning ion conductance microscopy to image A6 cells (2004) (73)
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange (2009) (72)
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus (2015) (72)
Determination of the fraction and stoichiometry of femtomolar levels of biomolecular complexes in an excess of monomer using single-molecule, two-color coincidence detection. (2006) (70)
Kinetic diversity of amyloid oligomers (2020) (70)
Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells. (2000) (69)
Programmable delivery of DNA through a nanopipet. (2002) (69)
Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy. (2014) (68)
A Quantitative Comparison of Single-Dye Tracking Analysis Tools Using Monte Carlo Simulations (2013) (68)
Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells (2011) (68)
DySCo: Quantitating Associations of Membrane Proteins Using Two-Color Single-Molecule Tracking (2009) (67)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates (2017) (66)
Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub (2018) (66)
An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy (2012) (66)
“Hearing” Bond Breakage. Measurement of Bond Rupture Forces Using a Quartz Crystal Microbalance (2000) (64)
On-demand delivery of single DNA molecules using nanopipets. (2015) (62)
Single-molecule analysis of human telomerase monomer. (2008) (59)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading. (2018) (59)
Local delivery of molecules from a nanopipette for quantitative receptor mapping on live cells. (2013) (58)
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale (2018) (55)
Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. (2005) (55)
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species (2017) (55)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression (2019) (54)
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers (2018) (54)
Direct and quantitative detection of bacteriophage by "hearing" surface detachment using a quartz crystal microbalance. (2001) (53)
Bayesian inference for improved single molecule fluorescence tracking. (2008) (53)
Ratiometric Analysis of Single-Molecule Fluorescence Resonance Energy Transfer Using Logical Combinations of Threshold Criteria: A Study of 12-mer DNA (2000) (53)
Capturing resting T cells: the perils of PLL (2018) (52)
Overtone spectra of C–H oscillators in cold molecules (1988) (52)
Evidence for resonance optical trapping of individual fluorophore-labeled antibodies using single molecule fluorescence spectroscopy. (2006) (52)
The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules (2016) (51)
A cell topography-based mechanism for ligand discrimination by the T cell receptor (2018) (51)
The T Cell Receptor Triggering Apparatus Is Composed of Monovalent or Monomeric Proteins* (2011) (49)
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy (2007) (47)
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions (2016) (47)
Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence. (2008) (47)
Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. (2007) (47)
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein (2016) (46)
Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. (2003) (46)
A microfluidic platform for trapping, releasing and super-resolution imaging of single cells (2016) (46)
A renewable nanosensor based on a glass nanopipette. (2006) (45)
Pipette-surface interaction: current enhancement and intrinsic force. (2013) (45)
Building Three-Dimensional Surface Biological Assemblies on the Nanometer Scale (2003) (45)
Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution. (2004) (44)
Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. (2004) (44)
Probing DNA Surface Attachment and Local Environment Using Single Molecule Spectroscopy (2001) (43)
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death (2020) (43)
Use of fluorescence resonance energy transfer to investigate the conformation of DNA substrates bound to the Klenow fragment. (1998) (43)
Single-molecule analysis of DNA immobilized on microspheres. (2000) (42)
Tracking diffusion of GM1 gangliosides and zona pellucida binding molecules in sperm plasma membranes following cholesterol efflux. (2010) (41)
Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells (2016) (41)
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms (2016) (41)
Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly. (2006) (40)
Contact-Free Scanning and Imaging with the Scanning Ion Conductance Microscope (2014) (40)
Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy. (2006) (40)
Oligomer Diversity during the Aggregation of the Repeat Region of Tau (2018) (40)
High-resolution label-free 3D mapping of extracellular pH of single living cells (2019) (39)
Single-Molecule Imaging Reveals that Small Amyloid-β1–42 Oligomers Interact with the Cellular Prion Protein (PrPC) (2014) (39)
Endocytic pathways: combined scanning ion conductance and surface confocal microscopy study (2008) (39)
In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease (2021) (39)
Characterization of a single molecule DNA switch in free solution. (2006) (38)
Fabrication of Three‐Dimensional Surface Structures with Highly Fluorescent Quantum Dots by Surface‐Templated Layer‐by‐Layer Assembly (2005) (38)
Imaging single virus particles on the surface of cell membranes by high-resolution scanning surface confocal microscopy. (2008) (38)
Characterization and application of controllable local chemical changes produced by reagent delivery from a nanopipet. (2008) (37)
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase (2020) (37)
Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence. (2009) (37)
Spectrally Resolved Photodynamics of Individual Emitters in Large-Area Monolayers of Hexagonal Boron Nitride. (2019) (37)
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure (2017) (37)
Optimized threshold selection for single-molecule two-color fluorescence coincidence spectroscopy. (2007) (36)
Two-state model of conformational fluctuation in a DNA hairpin-loop (2001) (35)
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (2018) (35)
Imaging and characterisation of the surface of live cells. (2011) (35)
Quantifying Co-Oligomer Formation by α-Synuclein (2018) (34)
Single molecule fluorescence under conditions of fast flow. (2012) (34)
A microfluidic device for the hydrodynamic immobilisation of living fission yeast cells for super-resolution imaging (2014) (34)
Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme (2018) (33)
Hydrodynamic trapping of molecules in lipid bilayers (2012) (33)
Investigating a quadruplex-ligand interaction by unfolding kinetics. (2006) (32)
A hybrid scanning mode for fast scanning ion conductance microscopy (SICM) imaging (2012) (32)
Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region (2013) (32)
Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy (2014) (32)
Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function (2017) (32)
MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling (2020) (31)
A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection. (2011) (31)
Optical Structural Analysis of Individual α‐Synuclein Oligomers (2018) (30)
Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity. (2005) (29)
Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution (2013) (29)
Infrared chemiluminescence using a SISAM spectrometer. Reactions producing vibrationally excited HF (1987) (28)
Potential biomedical applications of the scanned nanopipette. (2006) (28)
Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling. (2006) (28)
Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit. (2020) (27)
Detecting RNA base methylations in single cells by in situ hybridization (2017) (27)
Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States (2015) (26)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation (2020) (26)
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells (2018) (25)
Single-molecule two-colour coincidence detection to probe biomolecular associations. (2010) (25)
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme (2019) (25)
Single-Molecule Light-Sheet Imaging of Suspended T Cells. (2018) (25)
Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective. (2008) (25)
A novel light source for SICM–SNOM of living cells (2003) (25)
High resolution imaging using scanning ion conductance microscopy with improved distance feedback control (2008) (24)
Ultraviolet resonance Raman study of drug binding in dihydrofolate reductase, gyrase, and catechol O-methyltransferase. (1998) (24)
Direct Observation of Murine Prion Protein Replication in Vitro (2018) (22)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation (2021) (22)
Two-color fluorescence analysis of individual virions determines the distribution of the copy number of proteins in herpes simplex virus particles. (2007) (22)
The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation (2020) (22)
Inhibiting the Ca2+ Influx Induced by Human CSF (2017) (22)
Vibrational spectroscopy of mechanically compressed monolayers. (2003) (21)
Fluorescence coincidence spectroscopy for single-molecule fluorescence resonance energy-transfer measurements. (2008) (21)
Second harmonic generation at surfaces applied to corrosion inhibition (1994) (21)
Persistency of corrosion inhibitor films on c-steel under multiphase flow conditions. Part i: the jet-cylinder arrangement (1998) (21)
Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses. (2020) (21)
Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations† (2009) (20)
Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay (2013) (20)
Imaging the cell surface and its organization down to the level of single molecules (2013) (20)
Comparison of overtone-induced and electronic photochemistry of liquid tert-butyl hydroperoxide: supporting evidence for vibrational mode selectivity (1988) (20)
Measurements of the Adsorption Kinetics of a Cationic Surfactant in a Liquid Jet by Ellipsometry (1999) (19)
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies (2020) (19)
Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis (2018) (19)
A simple nanomixer for single-molecule kinetics measurements. (2006) (19)
The changing point-spread function: single-molecule-based super-resolution imaging (2014) (19)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species† †Electronic supplementary information (ESI) available: Additional methods and materials, supplementary figures. Representative TIRF images of PrP aggregates at dif (2019) (18)
Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe. (2011) (17)
Angular Approach Scanning Ion Conductance Microscopy (2016) (17)
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity (2022) (17)
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells (2021) (17)
Surface vibrational spectroscopy of lubricants adsorbed at the iron-water interface (1998) (16)
Virtual-'Light-Sheet' Single-Molecule Localisation Microscopy Enables Quantitative Optical Sectioning for Super-Resolution Imaging (2015) (16)
Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations. (2017) (16)
RNA conformation in catalytically active human telomerase. (2010) (16)
Absolute Quantification of Amyloid Propagons by Digital Microfluidics (2017) (16)
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease (2021) (15)
In-situ studies of polycrystalline copper during methanol synthesis at high pressure using sum frequency generation at surfaces. (2000) (14)
Citrullination of HP1γ chromodomain affects association with chromatin (2019) (14)
Scanning near-field optical microscopy in reflection mode imaging in liquid (1997) (14)
Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features. (2004) (14)
Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution (2018) (14)
Optical chemical imaging of tobacco mosaic virus in solution at 60-nm resolution. (1998) (14)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42. (2019) (13)
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive (2019) (13)
ThX – A next-generation probe for the early detection of amyloid aggregates (2019) (12)
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease (2019) (12)
Fluorescence studies of single biomolecules. (2004) (12)
Selective diffusion barriers separate membrane compartments. (2010) (12)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease (2022) (12)
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell (2018) (12)
ThX – a next-generation probe for the early detection of amyloid aggregates† (2020) (12)
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics (2020) (11)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity (2016) (11)
Evaluation of the Effect of Carbon Dioxide Corrosion Inhibitors on Cavitation Damage Caused during the Ultrasound Test (2004) (11)
Characterization of a novel light source for simultaneous optical and scanning ion conductance microscopy. (2002) (11)
How effective is internal excitation in promoting the HCl + 1,3-butadiene addition reaction? (1986) (11)
UV resonance Raman spectroscopy using a quasi–continuous—wave laser developed as an industrial analytical technique (1992) (11)
Label-free measurements of the diffusivity of molecules in lipid membranes. (2014) (11)
Sum Frequency Spectra in the C-H Stretch Region of Adsorbates on Iron (1993) (11)
Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates (2018) (10)
Bayesian inference of accurate population sizes and FRET efficiencies from single diffusing biomolecules. (2014) (10)
A microfluidic platform for trapping, releasing and super-resolution imaging of single cells. (2016) (10)
Single-molecule fluorescence coincidence spectroscopy and its application to resonance energy transfer. (2011) (10)
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease (2021) (9)
Taking T cells beyond the diffraction limit (2010) (9)
Effect of Cavitation on Carbon Dioxide Corrosion and the Development of a Test for Evaluating Inhibitors (2002) (9)
A second-harmonic generation study of a corrosion inhibitor on a mild steel electrode (1992) (9)
Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons (2020) (9)
Effects of mechanical compression on the vibrational spectrum of a self-assembled monolayer (2001) (9)
Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever (2018) (9)
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice (2020) (8)
α-Synuclein strains target distinct brain regions and cell types (2019) (8)
Studies of the adsorption of a corrosion inhibitor onto mild steel using surface second-harmonic generation (1992) (8)
A Single gD Glycoprotein Can Mediate Infection by Herpes simplex Virus (2013) (8)
Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling (2021) (7)
Persistency of corrosion inhibitor films on c-steel under multiphase flow conditions. Part ii: optical shg and electrochemical studies (1998) (7)
Calcium is a key factor in α-synuclein induced neurotoxicity (2016) (7)
A Simple Voltage Controlled Enzymatic Nanoreactor Produced in the Tip of a Nanopipet (2004) (7)
Monitoring Ca2+ elevations in individual astrocytes upon local release of amyloid beta in acute brain slices (2018) (7)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (2021) (7)
Ultraviolet Resonance Raman Spectroscopic Study of the Average Environment of Tyrosine in Native and Denatured Barnase (1997) (7)
Corrigendum: Nanoscale live-cell imaging using hopping probe ion conductance microscopy (2009) (7)
Separation and detection of bacteria using rupture event scanning. (2011) (7)
Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. (2006) (6)
Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase‐Separated Microdroplets (2020) (6)
A Model Corrosion Inhibitor for in Situ Spectroscopic Studies (2000) (6)
Optically heterodyned Raman-induced Kerr-effect spectroscopy using a white-light continuum (1990) (6)
Direct detection of whole bacteria using a nonlinear acoustic resonator (2020) (6)
Individual molecules of dye-labeled DNA act as a reversible two-color switch upon application of an electric field. (2004) (6)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses (2022) (5)
Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions (2020) (5)
Single-Molecule FRET Reveals Hidden Complexity in a Protein Energy Landscape (2015) (5)
Multiplexed optically heterodyned Raman-induced Kerr-effect spectroscopy in the blue. (1991) (5)
Titelbild: Two-Component Graded Deposition of Biomolecules with a Double-Barreled Nanopipette (Angew. Chem. 42/2005) (2005) (5)
Direct Digital Sensing of Proteins in Solution through Single-Molecule Optofluidics (2020) (5)
Single-Molecule Light-Sheet Microscopy with Local Nanopipette Delivery. (2021) (4)
pyFRET: A Python Library for Single Molecule Fluorescence Data Analysis (2014) (4)
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein† (2020) (4)
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides (2021) (4)
Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease (2022) (4)
Supporting information for: Quantifying Co-Oligomer Formation by Alpha-Synuclein (2018) (4)
Uncovering the universality of self-replication in protein aggregation and its link to disease (2022) (4)
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers (2021) (4)
A general in vitro assay to study enzymatic activities of the ubiquitin system. (2020) (3)
resPAINT: Accelerating Volumetric Super‐Resolution Localisation Microscopy by Active Control of Probe Emission (2022) (3)
Investigating the Interaction Between Characterized Amyloid-Beta Oligomers and the Prion Protein Receptor in Live Cells (2012) (3)
Constraining CD45 exclusion at close-contacts provides a mechanism for discriminatory T-cell receptor signalling (2017) (3)
DeepSinse: deep learning-based detection of single molecules (2021) (3)
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (3)
Structure-specific amyloid precipitation in biofluids (2022) (3)
Noncontact Nanoscale Imaging of Cells. (2021) (2)
Simpler and faster quartz crystal microbalance for macromolecule detection using Fixed Frequency Drive (2022) (2)
Single-Molecule Characterisation of Alpha-Synuclein Oligomers (2014) (2)
Sensitive and direct detection using rupture event scanning (REVS/spl trade/) (2002) (2)
Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging (2022) (2)
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (2)
Characterisation of particle-surface interactions via anharmonic acoustic transduction (2018) (2)
An economic, square-shaped flat-field illumination module for TIRF-based super-resolution microscopy (2021) (2)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (Adv. Mater. 33/2021) (2021) (2)
Membrane potential regulates the dynamic localisation of mammalian proteasomes (2018) (2)
A general in vitro assay to study enzymatic activities of the ubiquitin system (2019) (1)
Surface-Sensitive Molecular Information on Polymers from UV-Resonance Raman Spectroscopy (2003) (1)
Revealing the Stoichiometry of G Protein-Coupled Receptors (GPCRs) at the Cell Surface using Single Molecule Imaging (2013) (1)
Rational Design of Conformation-Specific Antibodies for Tau Oligomers (2020) (1)
Single molecule imaging of protein aggregation in Dementia: Methods, insights and prospects (2021) (1)
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species (2017) (1)
Single Molecule Fluorescence Studies of Amyloid Beta 1-42 Aggregation (2012) (1)
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients (2022) (1)
Material PROBING NEUROSERPIN POLYMERIZATION AND INTERACTION WITH AMYLOID-β PEPTIDES USING SINGLE MOLECULE FLUORESCENCE (2009) (1)
Detecting RNA base methylations in single cells by in situ hybridization (2018) (1)
Quantitative Characterization of Local Chemical Delivery through Nanopipette (2012) (1)
Inhibiting the Ca 2 + Influx In duced by Human CSF Graphical (2017) (1)
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation (2018) (1)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent inflammatory responses (2021) (1)
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale (2019) (1)
Second-harmonic generation as an in situ diagnostic for corrosion (1991) (1)
Direct digital sensing of protein biomarkers in solution (2023) (1)
Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer’s disease (2020) (1)
Single Molecule FRET Characterization of Oligomers from Alpha-Synuclein Early Onset Parkinson's Disease Mutants (2014) (1)
Construction of a liquid-liquid phase separation system from the gel-sol transition of elongated protein microgels in a crowding agent (2020) (1)
Combining Single-Molecule Techniques with Microfluidics for Protein Analysis (2016) (1)
Tau-Hsp70 interaction on the single molecule level (2013) (1)
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands† (2021) (1)
Allergens As Immuno-Modulatory Proteins: The Cat Dander Protein FelD1 Enhances Toll-Like Receptor Activation By Lipid Ligands (2012) (1)
IN VITRO MEASUREMENTS OF TAU AGGREGATE ELONGATION AND FRAGMENTATION RATES ALLOW THE MODELLING OF PRION-LIKE SPREADING IN HUMANS (2018) (0)
Scanning Ion Conductance Microscopy Allows In-Depth Investigation of Mechanosensitive Ion Channels (2013) (0)
Amyloid precipitation in biofluids using a structure-specific chemical antibody (2020) (0)
Single-Molecule Characte rization of the Interactions between Extracellular Chaperones and Toxic a-Synuclein Oligomers Graphical (2018) (0)
Utilising Super-Resolution Palm Imaging in Fission Yeast (2014) (0)
POLCAM: Instant molecular orientation microscopy for the life sciences (2023) (0)
Imaging T-cell activation: topography and features of early T-cell contacts (2022) (0)
Surface Charge Mapping Based on Scanning Ion Conductance Microscopy (2010) (0)
Alpha-Synuclein Modulates [Ca2+]c of Neurons and Astrocytes that Trigger Cell Death (2014) (0)
Cover Picture: Two-Component Graded Deposition of Biomolecules with a Double-Barreled Nanopipette (Angew. Chem. Int. Ed. 42/2005) (2005) (0)
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands. (2021) (0)
Screening of antibodies for the development of a fast and sensitive influenza A nucleoprotein detection using anharmonic detection technique (2014) (0)
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding (2020) (0)
The stoichiometric ‘signature’ of Rhodopsin-family G protein-coupled receptors (2017) (0)
Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity (2022) (0)
MECHANISM OF TOXICITY INDUCED BY AMYLOID-BETA AGGREGATES CHANGES DURING THE PROGRESSION OF ALZHEIMER’S DISEASE (2019) (0)
Site-Specific Hydration Dynamics Illuminates the Key Structural Features of Membrane-Bound -Synuclein (2014) (0)
Antigen discrimination by T cells relies on size-constrained microvillar contact (2023) (0)
Tau-Hsp70 interaction on the single molecule level (2013) (0)
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction (2016) (0)
Rapid, Label-Free, Direct Detection and Quantification of Escherichia coli Bacteria Using Nonlinear Acoustic Aptasensor (2017) (0)
High-density volumetric super-resolution microscopy (2023) (0)
Imaging rRNA Methylation in Bacteria by MR-FISH. (2019) (0)
deposition occurs during G 2 in fission yeastCnp 1 Quantitative single-molecule microscopy reveals that CENP-A (2012) (0)
Single-molecule light-sheet microscopy with local nanopipette delivery (2020) (0)
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease (2021) (0)
Applying Single Molecule Fluorescence Microscopy to Precisely Count Absolute Numbers of Proteins in Living Cells (2013) (0)
Single Molecule Studies Of Ubiquitin Unfolding (2009) (0)
Ismail living cardiovascular cells high-resolution technology for multi-parametric analysis of Scanning ion conductance microscopy : a convergent (2011) (0)
Measurement of protein binding with vastly improved time resolution using a quartz crystal microbalance driven at a fixed frequency (2017) (0)
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD (2017) (0)
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (0)
Differential effects of mutant alpha-synuclein monomers, oligomers and fibrils on mitochondria function and ROS production (2015) (0)
CHARACTERIZING PROTEIN AGGREGATES FROM THE HUMAN BRAIN (2018) (0)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms (2019) (0)
Rapid ultra-sensitive detection of influenza A nucleoproteins using a microfluidic nonlinear acoustic sensor (2014) (0)
Single-MoleculeFRET Reveals HiddenComplexity inaProteinEnergy Landscape (2015) (0)
Single-molecule imaging of suspended T cells (2018) (0)
A kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading Short title : Templated seeding of alpha-synuclein aggregation (2016) (0)
A sensitive and economical method to directly detect particles (2002) (0)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression (2019) (0)
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells (2018) (0)
Improved Photo Physical Properties of mEos3 for Single Molecule Tracking (2016) (0)
Detecting and Characterizing Amyloid-β1-40 Oligomers using Single Molecule Fluorescence (2010) (0)
Supplementary Figures and Methods (2013) (0)
Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1 (2018) (0)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation (2020) (0)
Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells (2018) (0)
Amyloid precipitation in bio uids using a structure- speci c chemical antibody (2021) (0)
TNF induces increased production of extracellular amyloid-  - and  -synuclein-containing aggregates by human Alzheimer(cid:146)s (2020) (0)
Capturing resting T cells: the perils of PLL (2018) (0)
Anharmonic acoustic effects during DNA hybridization on an electrochemical quartz crystal resonator (2018) (0)
Preparation of molecular arrays (2002) (0)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions Graphical Abstract Highlights (2018) (0)
Development of Voltage Switching Mode Scanning Electrochemical Microscopy for Topographical and Electrochemical Nanoscale Imaging of Living Cells (2012) (0)
MEGAHERTZ-GENERATED FEMTOLITER MICROFLUIDIC DROPLETS FOR SINGLE-MOLECULE-COUNTING IMMUNOASSAY (2013) (0)
Single Molecule Studies of Key Processes during the Initiation of the Adaptive Immune Response (2013) (0)
Development of a Combined Scanning Ion-Conductance and Nearfield Optical Microscope to Image Living Cells (1999) (0)
Characterization of full-length p53 aggregates and their kinetics of formation. (2022) (0)
Measurement of Resonance Frequency of a Quartz Crystal Oscillator with Immensely Improved Time Resolution Using a Fixed Frequency Drive (2017) (0)
3D Super-Resolution Imaging of Unperturbed Cells (2016) (0)
CHAPTER 2:Fluorophore Conjugates for Single Molecule Work (2012) (0)
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death (2020) (0)
The changing point-spread function: single-molecule-based super-resolution imaging (2014) (0)
Crystal structure of human CD45 extracellular region, domains d1-d4 (2016) (0)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018) (0)
News Release (1987) (0)
Size-Dependent Characterization of Alpha-Synuclein Aggregates Unveils their Toxicity (2020) (0)
Nanopipet Based Nanoprobes for Single-Cell Analysis (2014) (0)
Theoretical model for Human Telomerase RNA Monomer from FRET measurements. (2006) (0)
Erratum: Single-molecule analysis of human telomerase monomer (2008) (0)
PROTEIN AGGREGATION AND NEUROINFLAMMATION ARE INTERRELATED IN ALZHEIMER’S DISEASE (2018) (0)
Surfaces for Study of Receptor Dynamics on T Cells. (2023) (0)
Crystal structure of rat CD45 extracellular region, domains d3-d4 (2016) (0)
Tailoring Nanoprobes for Single-Cell Surgery (2014) (0)
Using Hydrodynamic Forces to Trap and Study Membrane-Associated Molecules in Lipid Bilayers (2013) (0)
A single-molecule approach to deciphering the mechanism of T-cell receptor triggering (2015) (0)
Probing the Interaction between a Nanopipette and a Soft Surface Using Scanning Ion Conductance Microscopy (SICM) (2010) (0)
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease (2021) (0)
Cover Feature: Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (ChemBioChem 19/2018) (2018) (0)
using the latest technology now provides evidence that the T cell antigen receptor and the adaptor Lat are confined to small islands, which cluster together after triggering of the T cell antigen receptor. (2010) (0)
SICM-Based Nanodelivery System for Local TRPV1 Stimulation (2015) (0)
The remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions Short title: The remarkably low affinity of CD4 for pMHC II (2016) (0)
Robust T-cell signaling triggered on soft polydimethylsiloxane-supported lipid-bilayers (2020) (0)
PI3K-Mediated Epithelial Sodium Channel Activity by Regulating the Apical Membrane Morphology of Renal Epithelial Cells (2008) (0)
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells (2021) (0)
Effect of Ultrasound on CO2 Corrosion and the Development of a Slug Flow Simulator (2001) (0)
Citrullination of HP1γ chromodomain affects association with chromatin (2019) (0)
Shedding light on aberrant interactions (2018) (0)
Optical microscopy and its application in the study of cells (2000) (0)
The Role of alpha-Synuclein Oligomerisation in Parkinson’s Disease (P1.043) (2014) (0)
Single Molecule Fluorescence Studies of Protein Aggregates and their role in Neurodegenerative Disease (2014) (0)
Single-Molecule Analysis of the Human Telomerase RNA center dot Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations (2018) (0)
Probing Membrane Domains and Diffusion Barriers in Live Sperm Cells Using Fluorescent Particle Tracking (2009) (0)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite (2020) (0)
Theoretical Analysis of Nano-scale Imaging by Ion Conductance Microscopy (2009) (0)
Dynamic Single-molecule Colocalization Imaging - A New Method For Examining Membrane Protein Association In Living Cells (2009) (0)
Platform AG: Imaging & Optical Microscopy: Instrument and Probes Developments (2009) (0)
Optical microscopy and their use in the investigation of cells (2000) (0)
Weighing one protein with light (2018) (0)
Accurate Intramolecular Distances by Single Molecule Confocal Spectroscopy: A Monte Carlo Markov Chain Analysis of Fluorescence Data from Freely Diffusing Biomolecules (2013) (0)
Accelerating paint superresolution imaging by active probe control (2022) (0)
Single-molecule analysis of G protein-coupled receptor 1 stoichiometry: approaches and limitations 2 (2017) (0)
Wales Andrew Wheatley Paul Wood Peter Wothers Dominic Wright An introduction to Cambridge Chemistry Academic staff (2012) (0)
ThX: a next generation probe for the early detection of amyloid aggregates (2022) (0)
Author response: Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub (2018) (0)
Crystal structure of human CD45 extracellular region, domains d1-d2 (2016) (0)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains (2022) (0)
Nanopore extended field-effect transistor for selective single-molecule biosensing (2017) (0)
ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression (2019) (0)
Crystal structure of human CD45 extracellular region, domains d1-d3 (2016) (0)
Addressable Macroscopic 2D networks self-assembled from nanometre size protein/DNA complexes (2006) (0)
Super-Resolution Imaging of T Cell Triggering Supports the Kinetic Segregation Model in the Adaptive Immune Response (2013) (0)
Next Generation SICM Allows Nanoscale Imaging Of Biological Processes In Real-time (2009) (0)
Molecular nanomechanics and local stimulus of individual biomolecules on the surface of cells (2013) (0)
Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics (2012) (0)
Screening of antibodies for the development of a fast and sensitivie influenza : A nucleoprotein detection on a nonlinear acoustic sensor (2014) (0)
A Single-Molecule Study of Toll-Like Receptor 4 Structure and Signalling (2014) (0)

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Other Resources About David Klenerman

en.wikipedia.org

What Schools Are Affiliated With David Klenerman?

David Klenerman is affiliated with the following schools:

Imperial College London
Stanford University
University of Cambridge