David Lloyd
#140,277
Most Influential Person Now
Irish chemist
David Lloyd 's AcademicInfluence.com Rankings
Download Badge
Chemistry
Why Is David Lloyd Influential?
(Suggest an Edit or Addition)According to Wikipedia, Professor David Lloyd is a Dublin-born and educated university executive and academic. His academic background was that of a chemist, specialising in computer aided drug design. He currently serves as Vice Chancellor and President of the University of South Australia;
David Lloyd 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries (2009) (144)
- Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents. (2010) (97)
- On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. (2004) (92)
- Advances in the science of estrogen receptor modulation. (2003) (88)
- Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects. (2010) (61)
- Beyond the Ligand‐Binding Pocket: Targeting Alternate Sites in Nuclear Receptors (2013) (60)
- Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones. (2011) (59)
- Scaffold hopping in de novo design. Ligand generation in the absence of receptor information. (2004) (58)
- Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping. (2007) (55)
- Considerations in Compound Database Preparation-"Hidden" Impact on Virtual Screening Results (2005) (54)
- Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene. (2002) (47)
- “True” Antiandrogens—Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer (2012) (44)
- Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. (2008) (42)
- Oncology exploration: charting cancer medicinal chemistry space. (2006) (40)
- Unbiasing Scoring Functions: A New Normalization and Rescoring Strategy (2007) (39)
- Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe. (2011) (37)
- Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells. (2001) (37)
- Target specific virtual screening: optimization of an estrogen receptor screening platform. (2007) (36)
- Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor. (2004) (36)
- The effect of tightly bound water molecules on the structural interpretation of ligand-derived pharmacophore models (2004) (36)
- Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin. (2009) (31)
- Estrogen receptors: molecular interactions, virtual screening and future prospects. (2006) (31)
- Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells (2010) (27)
- De novo drug design: integration of structure-based and ligand-based methods. (2004) (25)
- Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds. (2012) (25)
- The Vascular Targeting Agent Combretastatin-A4 and a Novel cis-Restricted β-Lactam Analogue, CA-432, Induce Apoptosis in Human Chronic Myeloid Leukemia Cells and Ex Vivo Patient Samples Including Those Displaying Multidrug Resistance (2010) (24)
- Rational targeting of peroxisome proliferating activated receptor subtypes. (2011) (22)
- Simple 1,2-aminoalcohols as strain-specific antimalarial agents. (2000) (21)
- Guanidinium-based derivatives: searching for new kinase inhibitors. (2014) (20)
- Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. (2010) (19)
- Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. (2009) (17)
- Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90. (2011) (17)
- Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design. (2011) (17)
- Retinazone Inhibits Certain Blood-Borne Human Viruses Including Ebola Virus Zaire (2014) (15)
- β-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells (2008) (15)
- Study of E/Z Isomerization in a Series of Novel Non-ligand Binding Pocket Androgen Receptor Antagonists (2012) (13)
- Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators. (2005) (13)
- Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold (2016) (12)
- Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects (2010) (12)
- On the Effects of Permuted Input on Conformational Sampling of Drug‐like Molecules: an Evaluation of Stochastic Proximity Embedding (2007) (10)
- Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II. (2005) (10)
- A topological study of prodrugs of 5-fluorouracil. (2002) (10)
- Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells (2007) (9)
- Theoretical studies of parent 1-, 2-, 3-pyrazolines and their methylated derivatives (2013) (9)
- Permuting input for more effective sampling of 3D conformer space (2006) (8)
- Molecular Topology Applied to the Discovery of 1-Benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole-5-one as a Non-Ligand-Binding-Pocket Antiandrogen (2014) (8)
- Rational ligand-based virtual screening and structure-activity relationship studies in the ligand-binding domain of the glucocorticoid receptor-α. (2009) (7)
- Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening. (2019) (7)
- Unbiasing Scoring Functions: A New Normalization and Rescoring Strategy. (2007) (7)
- Neutral alkaline-metal and alkaline-earth-metal derivatives of imidazole and benzimidazole. (2014) (6)
- Structure-Activity Relationships in Non-Ligand Binding Pocket (Non-LBP) Diarylhydrazide Antiandrogens (2013) (6)
- Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives. (2007) (6)
- Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor antagonists. (2006) (6)
- Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells (2016) (5)
- Redox systems as conduits for antimalarial compounds. (2001) (4)
- Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells. (2008) (4)
- Rational structure-based drug design and optimization in the ligand-binding domain of the glucocorticoid receptor-α. (2009) (4)
- Virtual screening of the estrogen receptor (2008) (3)
- A CONVENIENT ONE-POT SYNTHESIS OF 1,2-AMINOALCOHOLS (1998) (3)
- Synthesis, Biochemical and Molecular Modeling Studies of Antiproliferative Azetidinones Causing Microtubule Disruption and Mitotic Catastrophe. (2012) (3)
- Approaches to Scaffold Hopping. (2013) (2)
- Ethyl side-chain modifications in novel flexible antiestrogens--design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line. (2001) (1)
- A Convenient One-Pot Synthesis of 1,2-Amino Alcohols. (1998) (0)
- Recent advances in estrogen receptor antagonists. (2000) (0)
- Androgen Receptor Ligands - Europe WO2013076275 A1 (2013) (0)
This paper list is powered by the following services:
Other Resources About David Lloyd
What Schools Are Affiliated With David Lloyd ?
David Lloyd is affiliated with the following schools:
