David M. Sabatini

David M. Sabatini's AcademicInfluence.com Rankings

David M. Sabatini

Biology

#1112

World Rank

#1904

Historical Rank

#579

USA Rank

Cell Biology

#50

World Rank

#54

Historical Rank

#25

USA Rank

biology Degrees

Download Badge

Biology

David M. Sabatini's Degrees

PhD Cell Biology Johns Hopkins University
Doctorate Medicine Johns Hopkins University

Why Is David M. Sabatini Influential?

(Suggest an Edit or Addition)

According to Wikipedia, David M. Sabatini is an American scientist and a former professor of biology at the Massachusetts Institute of Technology. From 2002 to 2021, he was a member of the Whitehead Institute for Biomedical Research. He was also an investigator of the Howard Hughes Medical Institute from 2008 to 2021 and was elected to the National Academy of Sciences in 2016. He is known for his contributions in the areas of cell signaling and cancer metabolism, most notably the co-discovery of mTOR.

(See a Problem?)

David M. Sabatini's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

mTOR Signaling in Growth Control and Disease (2012) (7217)
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex (2005) (5505)
CellProfiler: image analysis software for identifying and quantifying cell phenotypes (2006) (4290)
mTOR: from growth signal integration to cancer, diabetes and ageing (2010) (3731)
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery (2002) (2939)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
Defining the role of mTOR in cancer. (2007) (2827)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. (2006) (2683)
mTOR Signaling in Growth, Metabolism, and Disease (2017) (2678)
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton (2004) (2637)
mTOR Signaling in Growth, Metabolism, and Disease (2017) (2535)
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 (2008) (2448)
Genetic Screens in Human Cells Using the CRISPR-Cas9 System (2013) (2407)
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009) (2300)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids (2010) (2100)
mTOR signaling at a glance (2009) (2057)
Cancer Cell Metabolism: Warburg and Beyond (2008) (2025)
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen (2006) (1749)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1* (2009) (1684)
Growing roles for the mTOR pathway. (2005) (1568)
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB (2012) (1486)
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs (1994) (1443)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. (2006) (1440)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase (2011) (1401)
mTOR and cancer: insights into a complex relationship (2006) (1341)
Lentivirus-delivered stable gene silencing by RNAi in primary cells. (2003) (1266)
A unifying model for mTORC1-mediated regulation of mRNA translation (2012) (1260)
Identification and characterization of essential genes in the human genome (2015) (1248)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. (2007) (1235)
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. (2010) (1174)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival (2009) (1163)
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. (1998) (1116)
mTOR at the nexus of nutrition, growth, ageing and disease (2020) (1045)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling (2011) (1018)
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity (2012) (988)
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway (2011) (986)
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (2003) (956)
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis (2015) (902)
Microarrays of cells expressing defined cDNAs (2001) (891)
CellProfiler: free, versatile software for automated biological image analysis. (2007) (859)
A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 (2013) (829)
Nutrient-sensing mechanisms and pathways (2015) (823)
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1 (2012) (811)
Sestrin2 is a leucine sensor for the mTORC1 pathway (2016) (789)
Cancer cell metabolism: one hallmark, many faces. (2012) (765)
mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s (2006) (707)
Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation (2002) (657)
Regulation of mTORC1 by amino acids. (2014) (645)
mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake (2012) (612)
The Pharmacology of mTOR Inhibition (2009) (579)
An Emerging Role of mTOR in Lipid Biosynthesis (2009) (574)
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides (2014) (569)
Regulation of mTORC1 and its impact on gene expression at a glance (2013) (553)
Highly parallel identification of essential genes in cancer cells (2008) (553)
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing (2010) (551)
An expanding role for mTOR in cancer. (2005) (530)
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 (2015) (522)
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. (2012) (518)
CellProfiler Analyst: data exploration and analysis software for complex image-based screens (2008) (516)
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway (2016) (506)
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer (2011) (491)
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function (2003) (485)
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras (2017) (465)
Minimizing the risk of reporting false positives in large-scale RNAi screens (2006) (454)
High fat diet enhances stemness and tumorigenicity of intestinal progenitors (2016) (442)
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. (2013) (440)
Tumours with PI3K activation are resistant to dietary restriction (2009) (436)
The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation (2002) (427)
mTOR and cancer: many loops in one pathway. (2009) (424)
Rapalogs and mTOR inhibitors as anti-aging therapeutics. (2013) (419)
The TSC-mTOR pathway regulates macrophage polarization (2013) (417)
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness (2015) (416)
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. (2009) (409)
Structure of the human mTOR complex I and its implications for rapamycin inhibition. (2010) (403)
mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin (2013) (399)
Genome-scale loss-of-function screening with a lentiviral RNAi library (2006) (396)
Amino acids and mTORC1: from lysosomes to disease. (2012) (393)
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis (2017) (387)
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival (2012) (382)
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning (2009) (374)
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. (2017) (371)
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. (2014) (359)
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes (2017) (350)
Stress and mTORture signaling (2006) (345)
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. (2007) (345)
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. (2014) (332)
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway (2017) (324)
Twenty-five years of mTOR: Uncovering the link from nutrients to growth (2017) (321)
Systematic genome-wide screens of gene function (2004) (320)
A Central role for mTOR in lipid homeostasis. (2013) (317)
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase (2017) (311)
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway (2016) (306)
A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate (2016) (306)
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. (2010) (295)
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism (2016) (291)
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient (2017) (289)
Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. (1995) (285)
mTOR Signaling. (2012) (279)
Rapamycin inhibits mTORC1, but not completely (2009) (274)
Response and acquired resistance to everolimus in anaplastic thyroid cancer. (2014) (264)
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. (2014) (262)
Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor (1996) (261)
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors (2016) (260)
Nutrient-Sensing Mechanisms across Evolution (2015) (258)
Cell microarrays and RNA interference chip away at gene function (2005) (239)
The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling (2013) (238)
Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex* (2005) (231)
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer (2016) (225)
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. (2018) (223)
NUFIP1 is a ribosome receptor for starvation-induced ribophagy (2018) (216)
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors (2012) (215)
Building mammalian signalling pathways with RNAi screens (2006) (213)
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile (2013) (213)
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. (2010) (209)
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. (2011) (207)
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 (2016) (207)
Separate Signals for Target Selection and Movement Specification in the Superior Colliculus (201)
Neural actions of immunophilin ligands. (1998) (200)
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 (2017) (198)
SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance (2015) (196)
Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer (2011) (195)
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. (1999) (193)
Immunophilins and nervous system (1995) (192)
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. (2011) (191)
Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase (2017) (188)
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death (2019) (186)
Histidine catabolism is a major determinant of methotrexate sensitivity (2018) (185)
Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition (2014) (179)
Nutrient regulation of mTORC1 at a glance (2019) (173)
Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division (2006) (173)
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse (2001) (171)
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. (2013) (168)
Systematic identification of signaling pathways with potential to confer anticancer drug resistance (2014) (165)
mTOR Mediated Anti-Cancer Drug Discovery. (2009) (161)
mTORC 1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H +-ATPase (2011) (160)
The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1 (2015) (159)
Dietary modifications for enhanced cancer therapy (2020) (156)
Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site*♦ (2005) (153)
Raptor and mTOR: subunits of a nutrient-sensitive complex. (2004) (144)
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (2015) (143)
Dietary and metabolic control of stem cell function in physiology and cancer. (2014) (137)
Cell-biological applications of transfected-cell microarrays. (2002) (135)
RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells (2004) (132)
Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens. (2004) (131)
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis (2010) (128)
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. (1998) (127)
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium (2019) (125)
Microarrays of lentiviruses for gene function screens in immortalized and primary cells (2006) (121)
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance (2015) (119)
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism (2018) (119)
A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens (2013) (117)
Functional interaction between RAFT1/FRAP/mTOR and protein kinase Cδ in the regulation of cap‐dependent initiation of translation (2000) (116)
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. (2011) (114)
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. (2018) (112)
Identification of an oncogenic RAB protein (2015) (109)
Colony stimulating factor‐1 (CSF‐1) stimulates temperature dependent phosphorylation and activation of the RAF‐1 proto‐oncogene product. (1990) (108)
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. (2012) (105)
Structural basis for the docking of mTORC1 on the lysosomal surface (2019) (104)
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. (2014) (102)
A CRISPR screen identifies a pathway required for paraquat-induced cell death (2017) (101)
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes (2018) (101)
Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics* (2012) (99)
Leading Edge Review mTOR Signaling in Growth Control and Disease (2013) (99)
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin (2011) (99)
MERAV: a tool for comparing gene expression across human tissues and cell types (2015) (97)
Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide (2014) (96)
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. (2020) (96)
RAFT 1 phosphorylation of the translational regulators p 70 S 6 kinase and 4 EBP 1 (1998) (95)
Rag proteins regulate amino-acid-induced mTORC1 signalling. (2009) (93)
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan (2014) (90)
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway (2018) (90)
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms (2018) (88)
Sestrin 2 is a leucine sensor for the mTORC 1 pathway (2016) (87)
Dihydroxyacetone phosphate signals glucose availability to mTORC1 (2020) (87)
The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity (*) (1995) (87)
Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors (2018) (80)
Genome-wide CRISPR screen for Zika virus resistance in human neural cells (2019) (78)
Applications of transfected cell microarrays in high-throughput drug discovery. (2002) (76)
Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2 (2010) (75)
RagA, but not RagB, is essential for embryonic development and adult mice. (2014) (74)
Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex (2019) (72)
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia (2021) (72)
Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2) (2014) (69)
MCART1/SLC25A51 is required for mitochondrial NAD transport (2020) (69)
Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive (2013) (69)
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2 (2012) (68)
Architecture of human Rag GTPase heterodimers and their complex with mTORC1 (2019) (67)
Regulation of the Rapamycin and FKBP-Target 1/Mammalian Target of Rapamycin and Cap-dependent Initiation of Translation by the c-Abl Protein-tyrosine Kinase* (2000) (67)
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility (2018) (66)
The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-rich Repeat-containing Protein 8D (2014) (63)
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo (2018) (63)
Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites (2017) (63)
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. (2017) (61)
Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson (2012) (60)
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion. (2020) (59)
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. (2014) (56)
Off-target effects associated with long dsRNAs in Drosophila RNAi screens. (2007) (53)
Fumarate is a terminal electron acceptor in the mammalian electron transport chain (2021) (52)
High‐Sensitivity sequencing of large proteins: Partial structure of the rapamycin‐fkbp12 target (1994) (52)
Amino acids and mTORC 1 : from lysosomes to disease (2012) (52)
Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance (2013) (50)
ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. (2016) (49)
Nutrients and growth factors in mTORC1 activation. (2013) (49)
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction (2020) (47)
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB4) as a Novel Autophagy Regulator by High Content shRNA Screening (2015) (47)
AMPK and p53 help cells through lean times. (2005) (44)
The Sestrins Interact with GATOR 2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC 1 Citation (2014) (43)
MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma (2012) (42)
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases (2019) (42)
Development of ATP-competitive mTOR inhibitors. (2012) (42)
Methods for High-Content , High-Throughput Image-Based Cell Screening (2006) (41)
Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. (2011) (39)
SnapShot: mTORC1 Signaling at the Lysosomal Surface (2012) (37)
The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism (2014) (35)
Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. (2013) (34)
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. (2015) (34)
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase (2017) (33)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates (2018) (31)
MFSD12 mediates the import of cysteine into melanosomes and lysosomes (2020) (31)
Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes. (2010) (31)
Loss of hepatic DEPTOR alters the metabolic transition to fasting (2017) (31)
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance (2019) (31)
eIF3: a connecTOR of S6K1 to the translation preinitiation complex. (2005) (30)
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. (2021) (30)
Neural roles of immunophilins and their ligands (1997) (27)
Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity (2015) (27)
Increased mTORC1 signaling UPRegulates stress. (2008) (25)
KICSTOR recruits GATOR 1 to the lysosome and is necessary for nutrients to regulate mTORC 1 (2017) (25)
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells (2020) (24)
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program (2019) (23)
Viral Packaging and Cell Culture for CRISPR-Based Screens. (2016) (23)
Single Guide RNA Library Design and Construction. (2016) (23)
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors (2018) (22)
The apo-structure of the leucine sensor Sestrin2 is still elusive (2016) (22)
mTOR at the nexus of nutrition, growth, ageing and disease (2020) (22)
TOR : target of rapamycin (2004) (22)
Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease (2020) (22)
Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. (2016) (21)
Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition (2020) (20)
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species (2020) (20)
A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells (2020) (20)
Lamming and Uncoupled from Longevity Rapamycin-Induced Insulin Resistance Is Mediated by mTORC 2 Loss (2012) (20)
The 12 kD FK506 Binding Protein FKBP12 Is Released in the Male Reproductive Tract and Stimulates Sperm Motility (1998) (19)
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance (2019) (19)
Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells (2017) (19)
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. (2016) (18)
Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. (2020) (17)
Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae. (2012) (16)
Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens. (2016) (16)
A radical role for TOR in longevity. (2011) (16)
Cell Size Control (2006) (16)
Cell biology: The TORC1 pathway to protein destruction (2016) (16)
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes (2022) (14)
Cooperative nutrient accumulation sustains growth of mammalian cells (2015) (14)
Structure of the nutrient-sensing hub GATOR2 (2022) (13)
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila (2022) (12)
A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC 1 Citation (2013) (12)
Huntingtin aggregates ask to be eaten (2004) (12)
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy (2021) (12)
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines. (2018) (11)
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC 1 Citation (2012) (11)
The CASTOR Proteins Are Arginine Sensors for the mTORC 1 Pathway Graphical (2016) (11)
The TASCC of Secretion (2011) (10)
Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability. (2011) (10)
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling (2021) (10)
Glyceraldehyde 3-phosphate dehydrogenase modulates nonoxidative pentose phosphate pathway to provide anabolic precursors in hypoxic tumor cells (2018) (10)
Targeting cancer metabolism: a bedside lesson (2012) (10)
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone (2020) (9)
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. (2017) (9)
DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation (2018) (8)
Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation (2002) (8)
GCN2 adapts protein synthesis to scavenging-dependent growth. (2021) (7)
Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer (2011) (7)
Growth signaling at the nexus of stem cell life and death. (2009) (7)
7 Growth Control through the mTOR Network (2004) (7)
The next decade of metabolism (2019) (6)
Pharmacologic Means of Extending Lifespan (2012) (6)
Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling (2020) (6)
Regulation of TOR Signaling in Mammals (2010) (5)
Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance (2020) (4)
Regulation of growth and metabolism (2014) (4)
mTORC1 regulates cytokinesis through activation of Rho-ROCK signaling (2015) (4)
Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival (2012) (3)
Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Subject Collection Signal Transduction The Hippo Pathway (2012) (3)
ATRAID, a genetic factor that regulates the clinical action of nitrogen-containing bisphosphonates on bone (2018) (3)
Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis (2021) (3)
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine (2022) (3)
Juxtacap Nucleotide Sequence Modulates eIF4E Binding and Translation (2017) (3)
Kang Starvation and Rapamycin mTORC 1 Phosphorylation Sites Encode Their Sensitivity to (2013) (3)
Philip Siekevitz: Bridging biochemistry and cell biology (2010) (2)
Rapamycin Analogs Reduce mTORC2 Signaling and Inhibit AKT Activation in AML. (2006) (2)
C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly (2019) (2)
Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis (2020) (2)
LRRC 8 D Mediates Transport of Blasticidin S 1 The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-Rich Repeat-Containing Protein 8 D (2014) (2)
Role of the mTOR Signaling Pathway in Disease (2006) (2)
Chapter 12 – Cell Growth (2008) (2)
12 – Cell Growth (2015) (2)
Cancer Cell Metabolism : One Hallmark , Many Faces Updated (2012) (2)
Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR , ATM , and ATR Citation (2013) (2)
Large-Scale Single-Guide RNA Library Construction and Use for Genetic Screens: CRISPR/Cas9-based Genetic Screens (2016) (2)
Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. (2020) (2)
A Different Way of Doing Things (2016) (1)
Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae (2012) (1)
Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (2016) (1)
Selectivity and binding kinetics of mTOR inhibitors 1 Kinome-wide selectivity profiling of ATP-competitive mTOR ( mammalian target of rapamycin ) inhibitors and characterization of their binding kinetics (2011) (1)
Control of Growth by the mTOR Pathway (2012) (1)
A Luman/CREB3–ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens (2014) (1)
Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance (2020) (1)
Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity (2022) (1)
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity (2022) (1)
mTOR-activating mutations in RRAGD cause kidney tubulopathy and cardiomyopathy (KICA) syndrome (2021) (1)
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells (2020) (1)
Author Correction: Tumours with PI3K activation are resistant to dietary restriction (2020) (1)
Nutrients versus growth factors in mTORC1 activation (2013) (1)
Liron Bar-Peled GTPases That Signal Amino Acid Sufficiency to mTORC 1 A Tumor Suppressor Complex with GAP Activity for the Rag (2013) (1)
Young and old genetically heterogeneous HET 3 mice on a rapamycin diet are glucose intolerant but insulin sensitive Citation (2013) (1)
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction (2022) (1)
TumourswithPI3Kactivationareresistant to dietary restriction (2009) (1)
Abstract IA10: Structure and dynamics of Rag heterodimers in a complex with mTORC1 (2020) (0)
Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2-Mediated Regulation of the mTORC Pathway (2008) (0)
Roberto Zoncu-ATPase + Mechanism That Requires the Vacuolar H mTORC 1 Senses Lysosomal Amino Acids Through an Inside-Out (2011) (0)
Abstract IA02: Regulation of growth by the mTOR pathway (2017) (0)
Modulateurs de Complexes de MTOR (2009) (0)
Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila (2020) (0)
TheSestrins InteractwithGA TOR 2 toNegativelyRegulate the Amino-Acid-Sensing Pathway Upstream of mTORC 1 Graphical (2014) (0)
Abstract IA15: Genetic screens to study cancer (2017) (0)
Abstract IA11: Systematic approaches to understanding cellular metabolism (2016) (0)
Disruption of the Rag-Rag ulator Complex by c 17 orf 59 Inhibits mTORC 1 Graphical (2015) (0)
Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis (2022) (0)
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors (2016) (0)
Abstract 1724: Genomic mechanisms of exquisite sensitivity and acquired resistance to everolimus in a patient with anaplastic thyroid carcinoma (2014) (0)
Science Signaling Podcast: 3 April 2012 (2012) (0)
signaling S 6 K pathway − TORC 1 Drosophila melanogaster regulators of Genome-scale RNAi on living-cell microarrays identifies novel Material Supplemental (2011) (0)
Abstract 4317: PTEN-null tumors cohabiting the same lung display differential Akt activation and sensitivity to dietary restriction. (2013) (0)
mTOR complex 2 (mTORC2) regulation of hepatic gene expression (2013) (0)
into a safe harbor locus in the human genome isogenic settings using zinc finger nuclease-driven transgenesis Functional genomics , proteomics , and regulatory DNA analysis in Material Supplemental (2010) (0)
Raptor-Rag-Ragulator complex (2019) (0)
Hepatic signaling by the mechanistic target of rapamycin complex 2 ( mTORC 2 ) Dudley (2013) (0)
Inhibition of specific mRNA translation–possible mechanism of rapamycin's inhibition of T-cell proliferation (1999) (0)
NEK10 Loss of Function Causes a Novel Human Motile Ciliopathy (2019) (0)
Genomics: CRISPR screen identifies genes (2014) (0)
Decision letter: Translation in amino-acid-poor environments is limited by tRNAGln charging (2020) (0)
Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease (2020) (0)
Abstract A22: Identification of a novel protein that blocks the Rag-Ragulator interaction and inhibits mTORC1 (2015) (0)
DDRE-22. TARGETING SERINE SYNTHESIS IN BRAIN METASTASIS (2021) (0)
activation in AML Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT (2010) (0)
Science Signaling Podcast: 8 November 2011 (2011) (0)
Correction for mTORC1 activates SREBP-lc and uncouples lipogenesis from gluconeogenesis, by Mathieu Laplante and (2010) (0)
Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates (2018) (0)
Abstract 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity (2017) (0)
Abstract IA-16: Control of growth by mTOR signaling (2009) (0)
Amino acids regulate mTORC1 (2019) (0)
Histidine catabolism is a major determinant of methotrexate sensitivity (2018) (0)
Dietary modifications for enhanced cancer therapy (2020) (0)
Abstract PR10: Serine biosynthesis from glucose regulates folate availability (2016) (0)
Abstract IA03: Regulation of growth by the mTOR pathway (2020) (0)
Protocol 1 : Single-Guide Library Design and Construction (2016) (0)
A High Throughput Automated Microscopy RNAi Screen for Modifiers of the DNA Damage Response to Ionizing Radiation (2008) (0)
Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2- Mediated Regulation of the mTORC Pathway PRINCIPAL INVESTIGATOR: PI: (2009) (0)
Selectivity and binding kinetics of mTOR inhibitors 2 (2011) (0)
The next decade of metabolism (2019) (0)
mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis (2017) (0)
Abstract SY01-01: Regulation of growth by the mTOR pathway. (2013) (0)
mTOR , ATM and ATR Characterization of Torin 2 , an ATP-competitive inhibitor of (2013) (0)
Identifying Novel Drug Targets for the Treatment of Tuberous Sclerosis Complex Using High Throughput Technologies. Addendum (2007) (0)
Crystal structure of the C7orf59-HBXIP dimer (2018) (0)
Structural biology: Better pictures of protein structures (2014) (0)
Jessie Transformation Region Elements Necessary for Human Cell Enumeration of the Simian Virus 40 Early (2002) (0)
Metabolism The Adaptor Protein p 66 Shc Inhibits mTOR-Dependent Anabolic ` (2014) (0)
ATM , and ATR Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR (2013) (0)
AKT Activation and Sensitivity to Dietary Restriction-Null Tumors Cohabiting the Same Lung Display Differential Pten (2013) (0)
Abstract PR04: mTOR mutations in cancer (2015) (0)
Cancer: How drugs boost resistance (2014) (0)
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium (2019) (0)
mTOR Signaling in Growth Control and Disease Citation (2013) (0)
TOR and Control of Cell Growth (2001) (0)
Architecture of the human GATOR 1 and GATOR 1 – Rag GTPases complexes Citation (2018) (0)
Cryo-EM structure of GATOR1 (2018) (0)
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death (2019) (0)
Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila (2022) (0)
Abstract A163: A diverse array of mutations in MTOR are hyperactivating and correlate with rapamycin sensitivity. (2013) (0)
Regulation of growth and metabolism (2014) (0)
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling (2021) (0)
Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis (2018) (0)
“Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2-Mediated Regulation of the mTORC Pathway” PRINCIPAL INVESTIGATOR: (2010) (0)
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance (2020) (0)
An interview with David Sabatini. (2013) (0)
Therapeutics , Targets , and Chemical Biology Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR , ATM , and ATR (2013) (0)
MCART1 is required for mitochondrial NAD transport (2020) (0)
Current Topics in Microbiology and Immunology (1978) (0)
Structure of the nutrient-sensing hub GATOR2 (2022) (0)
Growth control and metabolism (2012) (0)
Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity (2022) (0)
MFSD12 mediates the import of cysteine into melanosomes and lysosomes (2020) (0)
The mTOR kinase as a target for anti-cancer drugs (2010) (0)
Abstract A63: Whole-genome CRISPR/CAS9 screen using patient samples reveals JunB as a unique genetic liability (2020) (0)
Abstract PR02: Structural and functional analyses of GATOR1, a negative regulator of the mTORC1 pathway (2020) (0)
Biomembranes. Part K: Membrane biogenesis: assembly and targeting (prokaryotes, mitochondria, and chloroplasts). (1983) (0)
Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition (2020) (0)
Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance (2020) (0)
Zoology: Tobacco breath aids defence (2014) (0)
Studies of amino acid sensing by the mTORC 1 pathway (2017) (0)

This paper list is powered by the following services:

Other Resources About David M. Sabatini

en.wikipedia.org

What Schools Are Affiliated With David M. Sabatini?

David M. Sabatini is affiliated with the following schools:

David M. Sabatini's Academic­Influence.com Rankings