David Nachmansohn

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David Nachmansohn

Biology

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Biochemistry

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Biology

Why Is David Nachmansohn Influential?

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According to Wikipedia, David Nachmansohn was a German-Jewish biochemist responsible for elucidating the role of phosphocreatine in energy production in the muscles, and the role of the neurotransmitter acetylcholine in nerve stimulation. He is also recognised for his basic research into the biochemistry and mechanism underlying bioelectric phenomena.

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David Nachmansohn's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Chemical and molecular basis of nerve activity (1959) (408)
THE FORMATION OF ACETYLCHOLINE. A NEW ENZYME: "CHOLINE ACETYLASE" (1943) (261)
Metabolism and function (1950) (188)
A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal properties. (1956) (137)
An isolated single electroplax preparation. I. New data on the effect of acetylcholine and related compounds. (1957) (132)
STUDIES ON CHOLINESTERASE I. ON THE SPECIFICITY OF THE ENZYME IN NERVE TISSUE (1945) (132)
Distinction between Acetylcholine-Esterase and Other Choline Ester-splitting Enzymes. (1949) (125)
Acetylcholinesterase. X. Mechanism of the catalysis of acylation reactions. (1950) (117)
Studies on cholinesterase; purification of the enzyme from electric tissue by fractional ammonium sulfate precipitation. (1947) (106)
Studies on cholinesterase; kinetics of the inhibition of acetylcholine esterase. (1949) (91)
Metabolism and function of the nerve cell. (1952) (85)
Effects of inhibitors of choline esterase on the nerve action potential. (1946) (82)
Site of action of acetylcholine. (1948) (76)
Changes of Choline Esterase at End Plates of Voluntary Muscle Following Section of Sciatic Nerve (1940) (76)
The inhibitory effect of stilbamidine, curare and related compounds and its relationship to the active groups of acetylcholine esterase; action of stilbamidine upon nerve impulse conduction. (1950) (73)
Proteins in excitable membranes: their properties and function in bioelectricity are discussed. (1970) (73)
Principles of Receptor Physiology (1971) (73)
Choline acetylase specificity in relation to biological function. (1953) (70)
Choline esterase in voluntary muscle (1938) (67)
Studies on cholinesterase; on the mechanism of diisopropyl fluorophosphate action in vivo. (1947) (67)
Studies on choline acetylase; on the preparation of the coenzyme and its effect on the enzyme. (1946) (65)
Chemical factors controlling nerve activity. (1961) (64)
Acetylcholinesterase. IX. Structural features determining the inhibition by amino acids and related compounds. (1950) (61)
Photoregulation of biological activity by photochromic reagents. 3. Photoregulation of bioelectricity by acetylcholine receptor inhibitors. (1969) (61)
CHEMICAL MECHANISM OF NERVE ACTIVITY (1946) (56)
Proteins in excitable membranes. (1969) (55)
Action of Ions on Choline Esterase (1940) (55)
LOCALIZATION OF CHOLINE ESTERASE IN NERVE FIBERS. (1940) (53)
Choline acetylase. V. Esterifications and transacetylations. (1951) (51)
Electrical activity in electric tissue. I. The difference between tertiary and quaternary nitrogen compounds in relation to their chemical and electrical activities. (1955) (48)
EFFECT OF GLUTAMIC ACID ON THE FORMATION OF ACETYLCHOLINE (1943) (47)
CHEMICAL CONTROL OF THE PERMEABILITY CYCLE IN EXCITABLE MEMBRANES DURING ELECTRICAL ACTIVITY * (1966) (47)
Proteins in Excitable Membranes (1970) (45)
An attempt at an integral interpretation of nerve excitability. (1973) (44)
Choline esterase in primitive nervous systems (1942) (43)
RELATION BETWEEN ELECTRICAL CHANGES DURING NERVE ACTIVITY AND CONCENTRATION OF CHOLINE ESTERASE (1941) (43)
CHOLINE ESTERASE IN BRAIN AND SPINAL CORD OF SHEEP EMBRYOS (1940) (40)
Mechanisms of bioelectric activity in electric tissue. I. The response to indirect and direct stimulation of electroplaques of Electrophorus electricus. (1953) (40)
ACTION POTENTIAL AND ENZYME ACTIVITY IN THE ELECTRIC ORGAN OF ELECTROPHORUS ELECTRICUS. II. PHOSPHOCREATINE AS ENERGY SOURCE OF THE ACTION POTENTIAL (1943) (40)
CHOLINESTERASE ACTIVITY PER UNIT SURFACE AREA OF CONDUCTING MEMBRANES (1965) (38)
Organophosphate inhibitors of acetylcholine-receptor and -esterase tested on the electroplax. (1969) (38)
Rapid and Reversible Block of Electrical Activity by Powerful Marine Biotoxins (1960) (37)
A specific antidote against lethal alkyl phosphate intoxication. IV. Effects in brain. (1957) (36)
On The Physiological Significance of Choline Esterase * (1940) (36)
STUDIES ON CHOLINE ACETYLASE I. EFFECT OF AMINO ACIDS ON THE DIALYZED ENZYME. INHIBITION BY α-KETO ACIDS (1945) (35)
Cholinesterase at the End-Plates of Voluntary Muscle after Nerve Degeneration (1938) (34)
Biochemistry as part of my life. (1972) (34)
The Role of Acetylcholine in the Mechanism of Nerve Activity (1945) (33)
ON THE SPECIFICITY OF CHOLINE ESTERASE IN NERVOUS TISSUE. (1944) (33)
Studies on permeability in relation to nerve function, axonal conduction and synaptic transmission. (1950) (31)
Proteins of Excitable Membranes (1969) (30)
ON THE EFFECT OF DRUGS ON CHOLINESTERASE (1945) (28)
Overshoot and block of conduction by lipid-soluble acetylcholine analogues. (1958) (28)
Coupling of acetyl donor systems with choline acetylase. (1952) (27)
ACTION POTENTIAL AND ENZYME ACTIVITY IN THE ELECTRIC ORGAN OF ELECTROPHORUS ELECTRICUS (LINNAEUS): I. CHOLINE ESTERASE AND RESPIRATION (1942) (27)
ELECTRIC POTENTIAL AND ACTIVITY OF CHOLINE ESTERASE IN THE ELECTRIC ORGAN OF ELECTROPHORUS ELECTRICUS (LINNAEUS) (1941) (26)
Studies on choline acetylase; effect of citric acid. (1948) (26)
ACETYLCHOLINE AND THE PHYSIOLOGY OF THE NERVOUS SYSTEM. (1943) (26)
Studies on choline acetylase; the formation of acetylcholine in the nerve axon. (1946) (24)
On the energy source of the action potential in the electric organ of Electrophorus electricus. (1946) (24)
Actions on Axons, and Evidence for the Role of Acetylcholine in Axonal Conduction (1963) (24)
An improved isolated single electroplax preparation. I. Effect of compounds acting primarily at the synapses. (1960) (24)
Electrical activity in electric tissue. III. Modifications of electrical activity by acetylcholine and related compounds. (1955) (23)
Proteins in bioelectricity: the control of ion movements across excitable membranes. (1968) (23)
Cholinesterase in voluntary frog's muscle (1937) (22)
German-Jewish pioneers in science, 1900-1933 (1979) (21)
Chemical events in conducting and synaptic membranes during electrical activity. (1971) (21)
Cholinesterase in invertebrate muscles (1937) (20)
Proteins in Bioelectricity. Acetylcholine-Esterase and -Receptor (1971) (20)
Studies on cholinesterase; enzyme activity and voltage of the action potential in electric tissue. (1946) (19)
Inhibition of Choline Acetylase by α-Keto Acids.∗ (1944) (19)
Enzymatic synthesis of a compound with acetylcholine-like biological activity. (1949) (19)
Action of lipid-soluble quaternary ammonium ions on conducting membranes. (1958) (18)
STUDIES OF ACID PHOSPHOMONOESTERASES AND THEIR INHIBITION BY DIISOPROPYLPHOSPHOROFLUORIDATE. (1965) (18)
The role of acetylcholine in conduction. (1948) (17)
LOCALIZATION OF ENZYMES IN NERVES I. SUCCINIC DEHYDROGENASE AND VITAMIN B (1942) (16)
Mode of Blocking of Axonal Activity by Curare and Inhibitors of Acetyl-cholinesterase (1952) (16)
Similarities between active sites of acetylcholine receptor and acetylcholinesterase tested with quinolinium ions. (1966) (16)
Choline esterase in voluntary muscle (1939) (15)
Choline Esterase in the Central Nervous System (1937) (14)
"ELECTRICITY ELICITED BY AN ORGANIC CHEMICAL PROCESS". (1940) (14)
Basic aspects of nerve activity explained by biochemical analysis. (1962) (14)
RESTORATION BY A SPECIFIC CHEMICAL REACTION OF "IRREVERSIBLY" BLOCKED AXONAL ELECTRICAL ACTIVITY. (1964) (14)
Electrical activity evoked by a specific chemical reaction. (1960) (13)
Editorial: The Generation of Bioelectric Potentials (1955) (13)
Nerve excitability--toward an integrating concept. (1975) (12)
Similarity of effects of oxygen, sulfur, and selenium isologs on the acetylcholine receptor in excitable membranes of junctions and axons. (1966) (12)
ROLE OF ACETYLCHOLINE IN NEUROMUSCULAR TRANSMISSION * (1966) (12)
LOCALIZATION OF ENZYMES IN NERVES. II. RESPIRATORY ENZYMES (1943) (12)
Choline acetylase. VI. Substitution of adenosinetriphosphate acetate by thiolacetate. (1952) (10)
ACETYLCHOLINE FORMATION IN LOBSTER SENSORY AXONS. (1964) (10)
Presence of choline acetylase in striated and cardiac muscle. (1947) (10)
Effect of Di-Isopropyl Fluorophosphate (DFP) on the Action Potential of Muscle. (1946) (10)
Transduction of chemical into electrical energy. (1976) (10)
Otto Meyerhof A tribute on his 65th birtday (April 12, 1949) (1950) (9)
Proteins in Bioelectricity (1970) (9)
CHAPTER IX – Chemical Control of Nervous Activity: A. Acetylcholine (1950) (9)
On the Toxicity of Atabrine.∗ (1943) (8)
Isolation of serine phosphate from the active site of human prostatic acid phosphatase; inhibition of the enzyme by DFP. (1962) (8)
[104] Choline acetylase (1955) (8)
Molecular structure determining the action of local anesthetics on the acetylcholine receptor. (1965) (8)
Phosphocreatine as Energy Source of the Action Potential (1943) (8)
CHAPTER XI – Isolated Single Electroplax Preparation (1975) (8)
EFFECTS OF DORSAL ROOT SECTION ON CHOLINE ESTERASE CONCENTRATION IN SPINAL CORD OF CATS (1944) (7)
PROPERTIES AND FUNCTION OF PROTEINS IN EXCITABLE MEMBRANES: AN INTEGRAL MODEL OF NERVE EXCITABILITY * (1974) (7)
The in vitro reversibility of cholinesterase inhibition by diisopropyl fluorophosphate (DFP). (1947) (6)
CHEMICAL CONTROL OF BIOELECTRIC CURRENTS IN MEMBRANES OF CONDUCTING CELLS. (1964) (6)
[Metabolism and function of the nerve cell]. (1952) (5)
ON THE FORMATION OF ACETYLCHOLINE IN THE NERVE AXON. (1945) (5)
Effect of di-isopropyl fluorphosphate (DFP) on action potential and cholinesterase of nerve. (1947) (5)
ROLE OF ACETYLCHOLINE IN AXONAL CONDUCTION AND NEUROMUSCULAR TRANSMISSION (1959) (5)
BASIC PROBLEMS OF DRUG ACTION ON THE MYONEURAL JUNCTION (1959) (5)
THE CHEMICAL BASIS OF CLAUDE BERNARD'S OBSERVATIONS ON CURARE. (1963) (5)
[Electroencephalographic aspects of the antagonism between 2-pyridine aldoxime iodomethylate (PAM) and isopropyl methylfluorophosphate (sarin)]. (1960) (5)
ON THE LOCALIZATION OF ENZYMES IN NERVE FIBERS. (1942) (4)
On the role of acetylcholine in the mechanism of nerve activity. (1947) (4)
ON THE FORMATION OF ACETYLCHOLINE IN THE NERVE AXON. (1945) (4)
Proteins in bioelectrogenesis: the control of ion movements in excitable membranes. (1968) (4)
MECHANISMS OF BIOELECTRIC ACTIVITY IN ELECTRIC TISSUE (1953) (4)
Biochemical Foundation of an Integral Model of Nerve Excitability (1974) (4)
Molecular biology : elementary processes of nerve conduction and muscle contraction : a symposium sponsored by Columbia University and The Rockefeller Institute, held at The Rockefeller Institute from September 25th to 30th 1958 (1960) (3)
Effect of di-isopropyl fluorphosphate on action potential and choline esterase of nerve. (1946) (3)
Mechanisms of impulse transmission across neuromuscular junctions. (1955) (2)
CHAPTER I – Physical Events during Nerve Activity (1975) (2)
The generation of bioelectric potentials. (1955) (2)
The physico-chemical mechanism of nerve activity, by David Nachmansohn [and others. (1946) (2)
THE NEUROMUSCULAR JUNCTION—THE ROLE OF ACETYLCHOLINE IN EXCITABLE MEMBRANES (1973) (2)
CHAPTER VIII – Nerve Gases, Insecticides, and Antidotes (1975) (1)
[Conduction of nerve impulses at the molecular level]. (1957) (1)
Nerve Excitability: From Descriptive Phenomenology to Molecular Interpretation (1978) (1)
On the formation of acetylcholine by choline acetylase in the nerve axon. (1946) (1)
Importance of Structure and Organization for the Chemical Reactions in Excitable Membranes (1974) (1)
Lateralization of Bird (1)
Nerve excitability: Transition from descriptive phenomenology to chemical analysis of mechanisms (1977) (1)
Nerve function and irradiation effects. (1952) (1)
CHAPTER VII – Mechanism of Reactions Catalyzed by Acetylcholinesterase (1975) (1)
Chemical and molecular forces underlying nerve activity. (1960) (1)
Second Conference on Physicochemical Mechanism of Nerve Activity and Second Conference on Muscular Contraction (1960) (1)
Molecular basis of nerve activity : proceedings of the International Symposium in Memory of David Nachmansohn (1899-1983), Berlin (West) Germany, October 11-13, 1984 (1985) (1)
Acetylcholine — its role in nerve excitability (1976) (1)
CHAPTER V – Sequence of Energy Transformations (1975) (1)
Ultrastructure and Cellular Chemistry of Neural Tissue. Progress in Neurobiology. II (1959) (1)
[Excitable membrane. Macromolecules bound together in bioelectrogenesis]. (1967) (0)
Chemistry and Biochemistry in the Early 20th Century. The Kaiser Wilhelm Institutes in Berlin—Dahlem (1979) (0)
Response : Treatment of Organophosphate Poisoning (1970) (0)
CHAPTER XIII – The Complex Nature of the Permeability Change (1975) (0)
Meyerhof and biochemistry (1980) (0)
CHAPTER X – Action of Acetylcholine on the Receptor in Intact Cells (1975) (0)
Effect of anticholinesterases on conduction. (1948) (0)
Letter to the Editor (1962) (0)
CHAPTER II – Problems of Mechanisms Underlying Nerve Activity (1975) (0)
Worldwide Effects on Biochemistry Due to Nazi Persecution (1979) (0)
The Aims of the Symposium (1960) (0)
[Conduction of the nerve impulse and the synaptic transmission]. (1952) (0)
Concluding Remarks: Science and Society (1979) (0)
CHAPTER VI – Tentative Picture of the Role of the Acetylcholine System in the Permeability Change (1975) (0)
Transactions of the 5th conference, September 20, 21 and 22, 1954, Princeton, N.J. (1956) (0)
Relation between electrical changes during nerve activity and concentration of choline esterase by D. Nachmansohn and B. Meyerhof. (1968) (0)
Response : Proteins in Excitable Membranes (1970) (0)
CHAPTER IV – Inseparability of Conduction and Activity of Acetylcholinesterase (1975) (0)
CHAPTER XII – Effects of Lipid-soluble Quaternary Ammonium Ions on Conduction (1975) (0)
Biochemical basis of nerve activity (1961) (0)
Adenosinetriphosphatase and conduction of the nerve impulse. (1948) (0)
Chemical aspects of the transmission of nerve impulses. (1946) (0)
Letter to the Editor. (1962) (0)
The difference between pharmacological action and the physiological role of acetylcholine. (1948) (0)
Transactions of the first conference, March 2-3, 1950, New York, N.J. (1951) (0)
INTRODUCTORY REMARKS (1959) (0)
Fifty years ago: Acetylcholine — its role in nerve excitability (1976) (0)
CHAPTER III – Physiologically Significant Features of Acetylcholinesterase (1975) (0)
On the rôle of acetylcholine during nerve activity. (1946) (0)
CHAPTER XV – Synaptic Transmission: II. Localization of Cholinesterase at Junctions (1975) (0)
[Chemical factors controlling ion movements during nervous activity]. (1963) (0)
[Role of acetylcholine in the elementary processes of nerve conduction]. (1955) (0)
Nerve impulse : transactions of the second Conference, March 1-2, 1951, New York (1951) (0)
Ion transport across membranes ; incorporating papers presented at a symposium held at the College of Physicians & Surgeons, Columbia University, October, 1953 (1954) (0)
An Attempt at an Integral Interpretation of Nerve Excitability: basic excitation unit/proteins and bioclectricity/acetylcholinc receptor/threshold/synaptic transmission (1976) (0)
Nerve impulse : transactions of the Fourth Conference, March 4,5 and 6, 1953, Princeton, N.J. (1954) (0)
Developments in Chemistry and Physiology in the Nineteenth Century (1979) (0)
CHAPTER XVI – Synaptic Transmission: III. Differences between Axon and Synapse (1975) (0)
On the permeability of the nerve axon to diisopropyl fluorophosphate. (1946) (0)
THE LOCALIZATION OF ACETYLCHOLINESTERASE IN AXONAL MEMBRANES OF FROG NERVE FIBERS* (0)
Biochemistry of the Developing Nervous System . Proceedings of the first International Neurochemical Symposium, held at Magdalen College, Oxford, 13-17 July 1954. Heinrich Waelsch, Ed. Academic Press, New York, 1955. xvii + 537 pp. Illus. $11.50. (1956) (0)
CHAPTER XIV – Synaptic Transmission: I. Reevaluation of the Original Neurohumoral Transmitter Theory (1975) (0)
Nerve impulse : transactions of the Fifth Conference, September 20, 21 and 22, 1954, Princeton, N.J. (1956) (0)
Bioenergetics and Properties and Function of Proteins in Excitable Membranes Associated with Bioelectrogenesis (1972) (0)
[Published works of O. Meyerhof and his associates]. (1952) (0)
Atomic Physics in the Early Twentieth Century (1979) (0)
Inhibitors of choline acetylase. (1948) (0)
GENERATION AND INTENSIFICATION OF EFFECTS ON NERVOUS FUNCTION BY CHANGING MOLECULAR STRUCTURE (1962) (0)
CHAPTER IX – Properties of Choline Acetylase (1975) (0)
INTRAMITOCHONDRIAL PH CHANGES IN CATION ACCUMULATION BY BRITTON CHANCE AND LEENA MELA (0)
Effect of anticholinesterases on conduction of nerve and muscle. (1947) (0)
HIGHLIGHTS OF A FRIENDSHIP (1976) (0)
On the mechanism of the action of diisopropyl fluorophosphate. (1948) (0)
Nerve impulse : transactions of the first Conference, March 2-3, 1950, New York (1951) (0)

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