David R Kaplan

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David R Kaplan is affiliated with the following schools: McGill University, University of Chicago, Stanford University, Case Western Reserve University, Johns Hopkins University, University of Toronto, Harvard University

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David R Kaplan

Computer Science

#4330

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#4556

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Machine Learning

#813

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#824

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Artificial Intelligence

#1021

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#1039

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#1536

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#1612

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Computer Science

David R Kaplan's Degrees

PhD Computer Science Stanford University
Masters Computer Science Stanford University

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David R Kaplan's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt (1997) (2549)
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase (1995) (2107)
Neurotrophin signal transduction in the nervous system (2000) (1960)
PI3K: Downstream AKTion Blocks Apoptosis (1997) (1778)
Isolation of multipotent adult stem cells from the dermis of mammalian skin (2001) (1657)
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate (1997) (1573)
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. (1991) (1329)
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor (1991) (1218)
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF (1991) (1021)
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB (1991) (849)
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor (1991) (794)
A dermal niche for multipotent adult skin-derived precursor cells (2004) (739)
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation (1985) (699)
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses (1994) (569)
Signal transduction by the neutrophin receptors (1997) (539)
Neurotrophin signal transduction by the Trk receptor. (1994) (535)
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity (1987) (518)
An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. (2000) (497)
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. (2008) (446)
The TrkB-Shc Site Signals Neuronal Survival and Local Axon Growth via MEK and PI3-Kinase (2000) (436)
Interleukin 3-dependent survival by the Akt protein kinase. (1997) (399)
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. (2012) (392)
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex (1990) (390)
Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor (1989) (376)
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. (1988) (370)
p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells (1994) (356)
Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells (1993) (351)
Evidence that Embryonic Neurons Regulate the Onset of Cortical Gliogenesis via Cardiotrophin-1 (2005) (350)
Platelet alpha granules contain a growth factor for fibroblasts. (1979) (346)
Signal transduction by the neurotrophin receptors. (1997) (343)
BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain (2000) (343)
Early events in neurotrophin signalling via Trk and p75 receptors (1995) (328)
Neurotrophin signalling pathways regulating neuronal apoptosis (2001) (328)
P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors (1998) (302)
Developmental and mature expression of full‐length and truncated TrkB, receptors in the rat forebrain (1996) (292)
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. (1995) (291)
Depolarization and Neurotrophins Converge on the Phosphatidylinositol 3-Kinase–Akt Pathway to Synergistically Regulate Neuronal Survival (1999) (259)
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene. (1991) (247)
Interaction of Survival and Death Signaling in Basal Forebrain Neurons: Roles of Neurotrophins and Proneurotrophins (2006) (246)
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine (1991) (240)
NGF-stimulated retrograde transport of trkA in the mammalian nervous system (1995) (237)
The Cytoplasmic and Transmembrane Domains of the p75 and Trk A Receptors Regulate High Affinity Binding to Nerve Growth Factor* (2001) (237)
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. (1992) (230)
Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration (2008) (225)
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons (1995) (217)
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. (2010) (216)
Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells. (1995) (214)
Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation (1994) (208)
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. (1987) (206)
Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. (1995) (197)
Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. (2002) (195)
Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development (2007) (189)
Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. (2007) (188)
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. (2010) (184)
SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells (1993) (175)
Cell Cycle Regulators in the Neuronal Death Pathway of Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase 1 (2003) (174)
Signaling mechanisms underlying dendrite formation (2003) (174)
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation (1995) (173)
Phosphatidylinositol metabolism and polyoma-mediated transformation. (1986) (168)
On Trk for Retrograde Signaling (2001) (167)
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex (1990) (156)
Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis (1995) (154)
ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3 (2004) (154)
Truncated trkB Receptors on Nonneuronal Cells Inhibit BDNF-Induced Neurite Outgrowthin Vitro (1997) (152)
Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. (2017) (148)
Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: an immunocytochemical study (1998) (142)
Control of CNS Cell-Fate Decisions by SHP-2 and Its Dysregulation in Noonan Syndrome (2007) (140)
Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor* (1997) (138)
FoxP2 Regulates Neurogenesis during Embryonic Cortical Development (2013) (136)
APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction (2006) (135)
Analysis of the neurogenic potential of multipotent skin-derived precursors (2006) (132)
Endogenous microglia regulate development of embryonic cortical precursor cells (2011) (130)
Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. (2016) (129)
A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth. (1994) (129)
Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. (2019) (127)
Ligand-induced down-regulation of trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons (1997) (126)
HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells (2009) (125)
The p53 family in nervous system development and disease (2006) (121)
Nerve Growth Factor Induces Apoptosis in Human Medulloblastoma Cell Lines that Express TrkA Receptors (1997) (118)
Human Natural Killer Cells Mediate Killing of Intracellular Mycobacterium tuberculosis H37Rv via Granule-Independent Mechanisms (2001) (116)
Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma (2016) (114)
Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product. (1991) (114)
P63 Is an Essential Proapoptotic Protein during Neural Development (2005) (114)
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain (2010) (112)
Semaphorin 3F Antagonizes Neurotrophin-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse (2003) (109)
Expression of a Trk high affinity nerve growth factor receptor in the human prostate. (1995) (109)
A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification (2018) (108)
Activity-dependent activation of TrkB neurotrophin receptors in the adult CNS. (1999) (106)
Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. (2002) (104)
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. (2013) (104)
An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells. (2012) (102)
Interleukin‐6 Induces Expression of Peripherin and Cooperates with Trk Receptor Signaling to Promote Neuronal Differentiation in PC12 Cells (1996) (100)
Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products. (1984) (99)
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase (2003) (98)
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. (2005) (95)
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth (1999) (95)
p73 Regulates Neurodegeneration and Phospho-Tau Accumulation during Aging and Alzheimer's Disease (2008) (94)
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. (2011) (94)
Association of neurotrophin receptor expression and differentiation in human neuroblastoma. (1995) (94)
Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. (2009) (92)
Interaction with TrkA Immobilizes gp75 in the High Affinity Nerve Growth Factor Receptor Complex (*) (1995) (90)
Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis (1997) (88)
Gab1 Mediates Neurite Outgrowth, DNA Synthesis, and Survival in PC12 Cells* (1999) (87)
Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation (2015) (86)
Rapid Phosphorylation of Phospholipase Cγ 1 by Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 in Cultures of Embryonic Rat Cortical Neurons (1993) (85)
95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site (1992) (84)
An eIF4E1/4E-T Complex Determines the Genesis of Neurons from Precursors by Translationally Repressing a Proneurogenic Transcription Program (2014) (82)
N-myc Promotes Survival and Induces S-Phase Entry of Postmitotic Sympathetic Neurons (2002) (80)
SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions. (2004) (79)
Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. (2015) (79)
An Essential Role for the Integrin-Linked Kinase–Glycogen Synthase Kinase-3β Pathway during Dendrite Initiation and Growth (2006) (78)
Sox2-Mediated Regulation of Adult Neural Crest Precursors and Skin Repair (2013) (78)
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression (2020) (78)
Mobilizing endogenous stem cells for repair and regeneration: are we there yet? (2012) (77)
TrkC Isoforms with Inserts in the Kinase Domain Show Impaired Signaling Responses (*) (1996) (77)
K‐252b Selectively Potentiates Cellular Actions and trk Tyrosine Phosphorylation Mediated by Neurotrophin‐3 (1992) (76)
In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. (2009) (76)
The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons (2006) (76)
AKT-1 Regulates DNA-Damage-Induced Germline Apoptosis in C. elegans (2007) (73)
Evidence That ΔNp73 Promotes Neuronal Survival by p53-Dependent and p53-Independent Mechanisms (2004) (72)
A novel mechanism of immunosuppression mediated by ethanol. (1986) (71)
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens (2010) (70)
The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA (1996) (70)
TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors (2010) (68)
Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria. (2000) (65)
The Invulnerability of Adult Neurons: A Critical Role for p73 (2004) (64)
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor1 (2001) (62)
Selective Regulation of TrkA and TrkB Receptors by Retinoic Acid and Interferon-γ in Human Neuroblastoma Cell Lines (*) (1995) (61)
CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase (2009) (61)
Ankrd11 is a chromatin regulator involved in autism that is essential for neural development (2015) (61)
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma (2013) (59)
Cellular proteins that associate with the middle and small T antigens of polyomavirus (1988) (59)
Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system. (1996) (58)
Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells (*) (1995) (58)
Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase (1998) (58)
Neuronal MEK is important for normal fear conditioning in mice (2004) (57)
Signal transduction in c-met mediated motogenesis. (1993) (57)
Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance and Can be Safely Targeted for Telomerase Inhibition (2010) (56)
Direct Genesis of Functional Rodent and Human Schwann Cells from Skin Mesenchymal Precursors (2014) (55)
Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration. (2019) (54)
Axon diameter and axonal transport: In vivo and in vitro effects of androgens (2015) (52)
TrkA Induces Apoptosis of Neuroblastoma Cells and Does So via a p53-dependent Mechanism*[boxs] (2005) (52)
Mechanisms of transformation by polyoma virus middle T antigen. (1989) (52)
CD8 functions as an inhibitory ligand in mediating the immunoregulatory activity of CD8+ cells. (1990) (50)
System-Level Analysis of Neuroblastoma Tumor–Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma (2010) (50)
Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development (2018) (49)
TrkB Receptor Signaling Regulates Developmental Death Dynamics, But Not Final Number, of Retinal Ganglion Cells (2003) (49)
p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior (2013) (48)
Use of an Epstein-Barr virus episomal replicon for anti-sense RNA-mediated gene inhibition in a human cytotoxic T-cell clone. (1988) (48)
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma (2010) (47)
Axon growth inhibition: signals from the p75 neurotrophin receptor (2003) (44)
p63 Antagonizes p53 to Promote the Survival of Embryonic Neural Precursor Cells (2009) (43)
Clonal Depletion in Neonatal Tolerance (1974) (42)
Antigen-presenting cell engineering. The molecular toolbox. (1996) (42)
Studying signal transduction in neuronal cells: the Trk/NGF system. (1998) (42)
Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks (2016) (41)
Neurog1 and Neurog2 Control Two Waves of Neuronal Differentiation in the Piriform Cortex (2014) (41)
An immunoregulatory function for the CD8 molecule. (1989) (40)
Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors. (1994) (40)
Costello syndrome H-Ras alleles regulate cortical development. (2009) (39)
Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity. (1996) (39)
Neurotrophin-induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons. (1992) (39)
Nerve growth factor triggers microfilament assembly and paxillin phosphorylation in human B lymphocytes (1995) (38)
Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma (2007) (38)
Neurotrophins and neuronal versus glial differentiation in medulloblastomas and other pediatric brain tumors (1998) (37)
A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. (2016) (37)
A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis (2015) (36)
Insulin as a surface marker on isolated cells from rat pancreatic islets (1983) (36)
Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma. (2018) (34)
Neurobiology: A move to sort life from death (2004) (34)
The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis. (2020) (34)
p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor cells (2015) (33)
Mycoplasma infection of cell cultures: thymidine incorporation of culture supernatants as a screening test. (1984) (33)
Characterization of middle T antigen expressed by using an adenovirus expression system (1987) (33)
Intraparenchymal NGF Injections in Adult and Aged Rats Induce Long-Lasting Trk Tyrosine Phosphorylation (1996) (33)
Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells (2016) (33)
Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis. (2020) (33)
p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse (2010) (33)
Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA (1989) (32)
CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. (2014) (31)
Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging. (2018) (31)
Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo (1986) (30)
p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells (2014) (30)
Translating neural stem cells to neurons in the mammalian brain (2019) (30)
Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments (2019) (29)
TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival (2014) (29)
Antigen-dependent regulation of interleukin 2 receptor expression on cloned human cytotoxic T lymphocytes. (1984) (29)
Life and death decisions: a biological role for the p75 neurotrophin receptor (1998) (29)
Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. (1990) (28)
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. (2017) (27)
Peripheral Nerve Single-Cell Analysis Identifies Mesenchymal Ligands that Promote Axonal Growth (2020) (26)
To Die or Not to Die: Neurons and p63 (2007) (26)
Prevention of Apoptotic Neuronal Death by G Ganglioside (1995) (26)
Snail Coordinately Regulates Downstream Pathways to Control Multiple Aspects of Mammalian Neural Precursor Development (2014) (26)
Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis. (2010) (24)
Clonal dominance: loss and restoration in adoptive transfer. (1978) (24)
ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts (2018) (24)
RNAi screen identifies essential regulators of human brain metastasis-initiating cells (2017) (23)
Expression of polyoma early gene products in E. coli. (1985) (22)
Neurobiology. TRK makes the retrograde. (2002) (22)
Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro (1988) (22)
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease (2013) (21)
Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells (2020) (20)
BMI1 is a therapeutic target in recurrent medulloblastoma (2018) (20)
Membrane-associated interleukin 2 epitopes on the surface of human T lymphocytes. (1988) (20)
APPL 1 Associates with TrkA and GIPC 1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction (2006) (19)
PI-3 kinase and IP3: partners in NT3-induced synaptic transmission (2001) (19)
A novel neurofibromin (NF1) interaction with the leucine‐rich pentatricopeptide repeat motif‐containing protein links neurofibromatosis type 1 and the french canadian variant of leigh's syndrome in a common molecular complex (2013) (19)
Developing with BDNF: A Moving Experience (2007) (18)
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype (2008) (18)
Prokineticin signaling is required for the maintenance of a de novo population of c-KIT+ cells to sustain neuroblastoma progression (2014) (17)
Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair (2015) (17)
Regulation of allogeneic responses by expression of CD8 alpha chain on stimulator cells. (1990) (17)
TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors (2011) (17)
B cell heterogeneity. I. A study of B cell subpopulations involved in the reconstitution of an X-linked immune defect of B cell differentiation. (1979) (16)
Mobility of TrkA is regulated by phosphorylation and interactions with the low-affinity NGF receptor. (1998) (16)
A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human. (2017) (16)
First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases. (2019) (15)
In vivo activity of solid phase interleukin 2. (1991) (14)
A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria (2017) (14)
Delivery of interleukin 2 for immunotherapy. (1994) (14)
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism (2002) (13)
Special AT-rich Binding Protein-2 (SATB2) Differentially Affects Disease-causing p63 Mutant Proteins* (2011) (13)
Possible target antigens in autoimmune endocrine disease. (1984) (12)
Phase separation analysis of recombinant interleukin 2. (1991) (12)
Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes (2013) (12)
Tyrosine phosphorylation in signal transduction. (1988) (11)
Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system (2015) (11)
Solid phase interleukin 2. (1991) (10)
LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex. (2020) (10)
Alteration of clonal profile. I. Effect of sublethal irradiation on the responses to phosphorylcholine in BALB/c mice (1978) (10)
Signal transduction by receptor tyrosine kinases. (1992) (10)
Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche (2021) (10)
A Shared Transcriptional Identity for Forebrain and Dentate Gyrus Neural Stem Cells from Embryogenesis to Adulthood (2022) (10)
SATB 2 augments D Np 63 a in head and neck squamous cell carcinoma (2010) (9)
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. (2021) (9)
Prospects for anti-rejection therapies based upon CD8-dependent immunoregulation. (1993) (8)
Functional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone (1988) (8)
Oncogenes and Phosphatidylinositol Turnover a (1986) (7)
The Cytoplasmic and Transmembrane Domains of the p 75 and Trk A Receptors Regulate High Affinity Binding to NGF (2001) (7)
Oncogenes and phosphatidylinositol turnover. (1986) (7)
Rap1 is involved in the signal transduction of myelin-associated glycoprotein (2007) (7)
Cytometrically detected specific binding of interleukin 2 to cells. (1992) (6)
Signal Transduction by Trk Receptors (1995) (6)
Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging (2019) (6)
Center Stage for NGF in Peripheral (but Not Central) Sensory Neuron Outgrowth (2000) (6)
Large-scale production of polyoma middle T antigen by using genetically engineered tumors (1985) (5)
The Snail Transcription Factor Regulates the Numbers of Neural Precursor Cells and Newborn Neurons throughout Mammalian Life (2014) (4)
The Trkb-Shc site signals neuronal survival and axon growth via MEK and PI3-kinase (2000) (3)
When a Motor Goes Bad: A Kinesin Regulates Neuronal Survival (2006) (3)
Phosphoinositide kinase activity and transformation. (1986) (3)
Differential effects of sublethal irradiation on the humoral immune responses of adult and neonatal mice. (1978) (3)
Regulation of Neurotrophin Mammalian Visual System Receptors Maturation (1994) (2)
Nail-associated mesenchymal cells contribute to and are essential for dorsal digit tip regeneration. (2022) (2)
Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons (2021) (2)
Initiation of cell replication by cationic polypeptide hormones. (1980) (2)
Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development. (2015) (2)
FUNCTIONAL CONSEQUENCES OF ANTISENSE RNA-MEDIATED INHIBITION OF CD 8 SURFACE EXPRESSION IN A HUMAN T CELL CLONE (2003) (2)
A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. (2013) (2)
(H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling. (2020) (1)
Phosphatidylinositol kinases and cell transformation. (1986) (1)
Nervous System Aging, Degeneration, and the p53 Family (2011) (1)
An immunoregulatory function for the CD 8 molecule ( immunoregulation / CD 8 ' T lymphocytes / antisense RNA / mixed lymphocyte cultures / transplantation ) (1)
( Original Paper ) Potent and selective cytotoxic and cytostatic activity of JNJ-10198409 against neuroblastoma cells (2012) (0)
Therapeutics, Targets, Chemical Biology Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells (2011) (0)
Nerve Growth Factor Triggers Microfilament Assembly and Paxillirt Phosphorylation in Human B Lymphocytes (2003) (0)
Vitamin D Receptor activation attenuates Hippo pathway effectors and cell survival in metastatic neuroblastoma. (2022) (0)
Cell Acute Exposure to Maternally Administered IL-6 In Utero Causes Long-Lasting Perturbations in Adult Olfactory Neurogenesis (2013) (0)
The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool. (2023) (0)
Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells (2020) (0)
Ethanol immunosuppression in vitro (1986) (0)
The translational repressor Smaug2 regulates maintenance of mammalian neural stem cells (2015) (0)
Correction (2004) (0)
The translational regulators eIF4E and 4E-T form a repressive protein:mRNA complex that determines neural stem cell self-renewal versus differentiation (2015) (0)
- Kinase Pathway ′ via Phosphatidylinositol 3 Neuroblastoma Cells from Chemotherapy-induced Apoptosis Brain-derived Neurotrophic Factor Activation of TrkB Protects (2002) (0)
The Rho-specific GEF IFC regulates neural precursor fate determination during cortical development (2008) (0)
In Vivo Activity of Solid Phase Interleukin (2006) (0)
Embryonal cancer initiation: MYCN-mediated mechanisms of resistance to cell death causing embryonal cell persistence (2007) (0)
Lowry syndrome : A role for RSK 2 in mammalian neurogenesis (2010) (0)
A role for activated H-RAS in cortical development and costello syndrome (2008) (0)
Endocrine-gland vascular endothelial growth factor (EG-VEGF) in neuroblastoma tumor initiating cells (2010) (0)
Therapeutics , Targets , and Chemical Biology Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells (2011) (0)
Staufen 2 regulates neural fate determination and neuronal migration during mammalian cortical development (2010) (0)
REMOVED: Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development (2015) (0)
Expression of SV40 and polyoma T antigens in E. coli. (1983) (0)
OAP要旨:JNJ-10198409は神経芽腫がん細胞に対し選択的に細胞障害性と細胞増殖抑制性をもつ (2012) (0)
An activated SHP-2 mutant that causes noonan syndrome and is associated with cognitive impairments pertubs cell fates of cerebral cortex precursors (2006) (0)
Human cytotoxic T cell clones specific for type A influenza virus and restricted by class II MHC products (1984) (0)
Co-targeting ephrin receptor tyrosine kinases A 2 and A 3 in cancer stem cells reduces growth of recurrent glioblastoma . Running Title : Targeting EphA 2 and EphA 3 in recurrent GBM (2018) (0)
Supplemental Data S 1 AKT1 Regulates DNA-Damage-Induced Germline Apoptosis in C . elegans (0)
p73 regulates neurodegeneration, stem cell self-renewal, and phospho-Tau accumulation during aging and Alzheimer's disease (2009) (0)
Can be Safely Targeted for Telomerase Inhibition Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance (2010) (0)
Pancreatic islet cell surface insulin (1985) (0)
The p53 family member, p63, regulates neural precursor cell survival during cortical development (2008) (0)
Identification and Co-Targeting of EphA2/EphA3 Cancer Stem Cells in Recurrent Human Glioblastoma (2018) (0)
p75NTR-mediated axon degeneration is involved in myelin inhibition (2008) (0)
Clinical Cancer esearch an Cancer Biology tem-Level Analysis of Neuroblastoma Tumor – Initiating ls Implicates AURKB as a Novel Drug Target R Neuroblastoma (2010) (0)
Neuron , Volume 63 Supplemental Data CCM 2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase (2009) (0)
The Isolation and Sequence of the Gene Encoding T 8 (2017) (0)

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