David R. Liu
#17,954
Most Influential Person Now
American chemist
David R. Liu's AcademicInfluence.com Rankings
David R. Liuchemistry Degrees
Chemistry
#410
World Rank
#772
Historical Rank
#194
USA Rank
Organic Chemistry
#117
World Rank
#153
Historical Rank
#45
USA Rank
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Chemistry
Why Is David R. Liu Influential?
(Suggest an Edit or Addition)According to Wikipedia, David Ruchien Liu is an American molecular biologist and chemist. He is the Richard Merkin Professor, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; Thomas Dudley Cabot Professor of the Natural Sciences and Professor of Chemistry and Chemical Biology at Harvard University; and Howard Hughes Medical Institute Investigator.
David R. Liu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 (2009) (4965)
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage (2016) (2927)
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage (2017) (2166)
- Search-and-replace genome editing without double-strand breaks or donor DNA (2019) (1897)
- High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity (2013) (1315)
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity (2018) (1023)
- Sequence-Controlled Polymers (2013) (909)
- Base editing: precision chemistry on the genome and transcriptome of living cells (2018) (868)
- Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors (2020) (823)
- CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes (2017) (779)
- A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. (2009) (763)
- Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification (2014) (761)
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo (2014) (754)
- The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing (2010) (686)
- Methods for the directed evolution of proteins (2015) (610)
- CRISPResso2 provides accurate and rapid genome editing sequence analysis (2019) (559)
- Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions (2017) (538)
- A System for the Continuous Directed Evolution of Biomolecules (2011) (492)
- Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity (2017) (486)
- Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein. (2016) (485)
- Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction (2018) (482)
- Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection (2011) (452)
- DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules. (2004) (435)
- Supercharging proteins can impart unusual resilience. (2007) (428)
- A general strategy for the evolution of bond-forming enzymes using yeast display (2011) (419)
- Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles (2016) (401)
- Prime genome editing in rice and wheat (2020) (393)
- Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo (2014) (370)
- DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles (2004) (369)
- Predictable and precise template-free CRISPR editing of pathogenic variants (2018) (355)
- Small Molecule-Triggered Cas9 Protein with Improved Genome-Editing Specificity (2015) (348)
- Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents (2017) (348)
- Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (318)
- Photoswitching Mechanism of Cyanine Dyes (2009) (315)
- Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal (2011) (302)
- Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery (2017) (301)
- How pathogenic bacteria evade mammalian sabotage in the battle for iron (2006) (297)
- A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing (2020) (290)
- The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2 (2006) (279)
- Autonomous Multistep Organic Synthesis in a Single Isothermal Solution Mediated by a DNA Walker (2010) (244)
- Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins (2009) (232)
- Reaction discovery enabled by DNA-templated synthesis and in vitro selection (2004) (210)
- Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors (2020) (209)
- Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses (2019) (204)
- A Biomolecule-Compatible Visible Light-Induced Azide Reduction from a DNA-Encoded Reaction Discovery System (2010) (203)
- Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity (2014) (200)
- Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones (2014) (192)
- Small-molecule discovery from DNA-encoded chemical libraries. (2011) (188)
- Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein (2010) (179)
- In Vivo Base Editing Rescues Hutchinson-Gilford Progeria Syndrome in Mice (2020) (178)
- CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes (2017) (170)
- Continuous evolution of SpCas9 variants compatible with non-G PAMs (2020) (167)
- Continuous evolution of base editors with expanded target compatibility and improved activity (2019) (166)
- In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. (2005) (165)
- Analysis and minimization of cellular RNA editing by DNA adenine base editors (2019) (165)
- A de novo protein binding pair by computational design and directed evolution. (2011) (164)
- Enzyme-Free Translation of DNA into Sequence-Defined Synthetic Polymers Structurally Unrelated to Nucleic Acids (2013) (162)
- Enhanced prime editing systems by manipulating cellular determinants of editing outcomes (2021) (162)
- Continuous directed evolution of aminoacyl-tRNA synthetases (2017) (157)
- Directed evolution of ligand dependence: small-molecule-activated protein splicing. (2004) (156)
- Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors (2019) (155)
- Rewritable multi-event analog recording in bacterial and mammalian cells (2018) (153)
- A DNA-based molecular probe for optically reporting cellular traction forces (2014) (153)
- In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. (2005) (148)
- LC/MS analysis of cellular RNA reveals NAD-linked RNA (2009) (148)
- Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation (2017) (146)
- In vivo base editing of post-mitotic sensory cells (2018) (144)
- Engineered pegRNAs improve prime editing efficiency (2021) (142)
- Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes. (2003) (127)
- Reprogramming the specificity of sortase enzymes (2014) (127)
- DNA-enabled self-assembly of plasmonic nanoclusters. (2011) (126)
- Development of potent in vivo mutagenesis plasmids with broad mutational spectra (2015) (126)
- In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors (2010) (125)
- A New Functional Suppressor tRNA/ Aminoacyl-tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins (2000) (125)
- Expanding the reaction scope of DNA-templated synthesis. (2002) (124)
- Directed evolution and substrate specificity profile of homing endonuclease I-SceI. (2006) (123)
- Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection. (2008) (121)
- Negative selection and stringency modulation in phage-assisted constinuous evolution (2014) (120)
- Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes (2007) (120)
- DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes. (2008) (118)
- Continuous evolution of B. thuringiensis toxins overcomes insect resistance (2016) (115)
- Multistep small-molecule synthesis programmed by DNA templates. (2002) (112)
- Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning (2020) (112)
- A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9 (2019) (111)
- Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins (2022) (109)
- Massively parallel assessment of human variants with base editor screens (2020) (108)
- Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase (2020) (108)
- Second-Generation DNA-Templated Macrocycle Libraries for the Discovery of Bioactive Small Molecules (2018) (106)
- Programmable deletion, replacement, integration, and inversion of large DNA sequences with twin prime editing (2021) (102)
- Base editing of haematopoietic stem cells rescues sickle cell disease in mice (2021) (99)
- Discovery and biological characterization of geranylated RNA in bacteria (2012) (98)
- Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. (2015) (97)
- A chemical screen for biological small molecule–RNA conjugates reveals CoA-linked RNA (2009) (97)
- A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. (2011) (96)
- Engineering a ligand-dependent RNA transcriptional activator. (2004) (92)
- Continuous directed evolution of DNA-binding proteins to improve TALEN specificity (2015) (90)
- Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution (2013) (90)
- Editing the Genome Without Double-Stranded DNA Breaks. (2017) (84)
- Nucleic acid evolution and minimization by nonhomologous random recombination (2002) (83)
- Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers. (2009) (82)
- Cellular uptake mechanisms and endosomal trafficking of supercharged proteins. (2012) (82)
- A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations (2014) (81)
- In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness (2020) (80)
- Two enabling architectures for DNA-templated organic synthesis. (2003) (79)
- Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells. (2012) (79)
- Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment (2010) (76)
- High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells (2020) (75)
- Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model (2011) (74)
- In vivo evolution of an RNA-based transcriptional activator. (2003) (74)
- Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme (2018) (74)
- Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents. (2007) (72)
- An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids (2009) (71)
- PrimeDesign software for rapid and simplified design of prime editing guide RNAs (2020) (70)
- DNA capture by a CRISPR-Cas9–guided adenine base editor (2020) (70)
- Creating small-molecule-dependent switches to modulate biological functions. (2005) (68)
- Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning (2021) (68)
- Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks (2019) (66)
- Phage-assisted continuous evolution of proteases with altered substrate specificity (2017) (66)
- A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. (2006) (65)
- Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure (2010) (65)
- Targeting fidelity of adenine and cytosine base editors in mouse embryos (2018) (64)
- A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis (2011) (63)
- Continuous directed evolution of proteins with improved soluble expression (2018) (62)
- In vivo continuous directed evolution. (2015) (62)
- Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase (2017) (61)
- Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers (2017) (59)
- Determining the specificities of TALENs, Cas9, and other genome-editing enzymes. (2014) (59)
- Directed evolution of protein enzymes using nonhomologous random recombination. (2004) (59)
- Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing (2020) (58)
- Analysis of Active Site Residues in Escherichia coli Chorismate Mutase by Site-Directed Mutagenesis (1996) (58)
- In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites (2013) (57)
- Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis (1996) (57)
- Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells. (2011) (56)
- The NIH Somatic Cell Genome Editing program (2021) (53)
- DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers (2012) (53)
- Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs. (2020) (52)
- Precision genome editing using cytosine and adenine base editors in mammalian cells (2021) (52)
- Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles (2011) (52)
- Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance (2016) (51)
- Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope (2020) (51)
- Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates (2014) (51)
- One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. (2018) (51)
- Site-specific incorporation of photoisomerizable azobenzene groups into ribonuclease S (1997) (50)
- Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2 (2019) (50)
- Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. (2006) (48)
- Translation of DNA into synthetic N-acyloxazolidines. (2004) (48)
- Ordered multistep synthesis in a single solution directed by DNA templates. (2005) (48)
- In vivo somatic cell base editing and prime editing. (2021) (48)
- Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection. (2017) (48)
- Novel selection methods for DNA-encoded chemical libraries. (2015) (48)
- Dissecting protein structure and function using directed evolution (2007) (47)
- Generating New Molecular Function: A Lesson from Nature (1999) (46)
- Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity. (2003) (46)
- A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells (2016) (45)
- Recent advances in the in vitro evolution of nucleic acids. (2002) (45)
- Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein. (2006) (45)
- Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis (2020) (44)
- DNA-templated functional group transformations enable sequence-programmed synthesis using small-molecule reagents. (2005) (44)
- The developing toolkit of continuous directed evolution (2020) (44)
- Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. (2006) (43)
- Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases. (2016) (43)
- A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. (2013) (42)
- Development of a formaldehyde biosensor with application to synthetic methylotrophy (2018) (42)
- Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions (2009) (38)
- Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis. (2002) (38)
- Therapeutic in vivo delivery of gene editing agents (2022) (37)
- Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues. (2018) (36)
- Analytical Devices Based on Direct Synthesis of DNA on Paper. (2016) (36)
- CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA (2022) (36)
- An in vivo selection system for homing endonuclease activity. (2002) (35)
- Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression (2020) (34)
- Solving chemical problems through the application of evolutionary principles. (2007) (34)
- Discovery of widespread GTP-binding motifs in genomic DNA and RNA. (2013) (34)
- Targeted antithrombotic protein micelles. (2015) (32)
- The Methyl Group at C(10) of 2,3-Oxidosqualene is Crucial to the Correct Folding of This Substrate in the Cyclization-Rearrangement Step of Sterol Biosynthesis (1992) (32)
- In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A (2016) (30)
- Stereoselectivity in DNA-templated organic synthesis and its origins. (2003) (30)
- Effects of template sequence and secondary structure on DNA-templated reactivity. (2008) (29)
- Synthesis of Acyclic α,β-Unsaturated Ketones via Pd(II)-Catalyzed Intermolecular Reaction of Alkynamides and Alkenes (2007) (29)
- Immobilization of Actively Thromboresistant Assemblies on Sterile Blood‐Contacting Surfaces (2014) (29)
- Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme (2019) (29)
- Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling (2014) (28)
- First demonstration of a carbocation-olefin cyclization route to the lanosterol series (1994) (28)
- Nucleic-acid-templated synthesis as a model system for ancient translation. (2004) (27)
- Reactivity-Dependent PCR: Direct, Solution-Phase in Vitro Selection for Bond Formation (2009) (27)
- Enzyme Mechanisms for Polycyclic Triterpene Formation (2000) (26)
- Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells (2018) (25)
- Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity (2021) (23)
- The Generality of DNA‐Templated Synthesis as a Basis for Evolving Non‐Natural Small Molecules. (2001) (22)
- Phage-assisted continuous and non-continuous evolution (2020) (21)
- High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases (2019) (21)
- In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration (2022) (19)
- Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage (2018) (18)
- Improved base excision repair inhibition and bacteriophage (2017) (18)
- Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis. (2005) (16)
- Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid β-protein (2020) (15)
- Simultaneous targeting of linked loci in mouse embryos using base editing (2019) (15)
- Side-chain determinants of biopolymer function during selection and replication (2019) (15)
- Discovery of a mRNA mitochondrial localization element in Saccharomyces cerevisiae by nonhomologous random recombination and in vivo selection (2007) (14)
- An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells (2019) (14)
- Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. (2016) (13)
- Disruption of HIV-1 Co-Receptors CCR5 and CXCR4 in Primary Human T Cells and Hematopoietic Stem and Progenitor Cells Using Base Editing. (2021) (11)
- Programmable large DNA deletion, replacement, integration, and inversion with twin prime editing and site-specific recombinases (2021) (10)
- In vivo evolution of an RNA-based transcriptional silencing domain in S. cerevisiae. (2007) (10)
- Translating DNA into Synthetic Molecules (2004) (10)
- Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection. (2005) (10)
- Voices of chemical biology. (2015) (9)
- Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. (2006) (9)
- Binding and stability determinants of the PPARgamma nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection. (2006) (8)
- Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects (2021) (8)
- Identification of eukaryotic promoter regulatory elements using nonhomologous random recombination (2007) (8)
- Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors (2021) (8)
- Multimodal small-molecule screening for human prion protein binders (2020) (8)
- Mechanisms of angiogenic incompetence in Hutchinson–Gilford progeria via downregulation of endothelial NOS (2021) (7)
- Disulfide-compatible phage-assisted continuous evolution in the periplasmic space (2021) (7)
- A naturally occurring, noncanonical GTP aptamer made of simple tandem repeats (2014) (7)
- Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells (2021) (7)
- Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants (2019) (6)
- Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity (2019) (6)
- Analysis and comparison of genome editing using CRISPResso2 (2018) (6)
- A rechargeable anti-thrombotic coating for blood-contacting devices. (2021) (5)
- Nucleic acids: new life, new materials. (2013) (5)
- Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (5)
- Synthesis of acyclic alpha,beta-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes. (2007) (4)
- Proteolysis Targeting Chimeras With Reduced Off-targets (2021) (4)
- Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells (2020) (4)
- Engineering a Ligand-Dependent RNA (2004) (4)
- Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors (2019) (4)
- Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing (2020) (3)
- Author Correction: Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules (2019) (3)
- Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling (2020) (3)
- Comprehensive Analysis of CRISPR Base Editing Outcomes for Multimeric Protein (2022) (2)
- Base editor treats progeria in mice. (2021) (2)
- Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding (2014) (2)
- DNA-Templated Organic Synthesis (DTS): A Novel Approach to the Discovery of Functional Small Molecules Based on Nature's Evolutionary Principles (2008) (2)
- Reconstruction of evolving gene variants and fitness from short sequencing reads (2021) (2)
- Publisher Correction: Precision genome editing using cytosine and adenine base editors in mammalian cells (2021) (1)
- Phage-assisted continuous evolution of botulinum neurotoxin light chains generates novel light chains with modified snare cleavage specificity (2018) (1)
- Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases (2019) (1)
- Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 individuals (2021) (1)
- Creating Rechargeable Antithrombotic Surfaces for Implantation via Enzyme-Mediated Ligation: A Novel System for Keeping Medical Devices Functional (2017) (1)
- Errata: Continuous directed evolution of aminoacyl-tRNA synthetases. (2018) (1)
- Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning (2022) (1)
- Synthesis of Acyclic α,β‐Unsaturated Ketones via Pd(II)‐Catalyzed Intermolecular Reaction of Alkynamides and Alkenes. (2007) (1)
- Nucleobase editors comprising nucleic acid programmable dna binding proteins (2018) (1)
- Abstract CT050: Expansion cohort of Phase I study of oral sapacitabine and oral seliciclib in patients with metastatic breast cancer andBRCA1/2mutations (2019) (1)
- Massively parallel base editing to map variant effects in human hematopoiesis (2023) (0)
- Publisher Correction: Side chain determinants of biopolymer function during selection and replication (2019) (0)
- In silico and in vitro co-evolution of a high affinity complementary protein-protein interface (2011) (0)
- 374 CRISPR/Cas9-base editing mediated correction for recessive dystrophic epidermolysis bullosa (2019) (0)
- Evolution of novel Molecular Function (2002) (0)
- Large protein folds observed by NMR (2005) (0)
- Reprogramming the Specificity of Sortase Enzymes by Directed Evolution (2014) (0)
- Abstract 3996: A novel 13-basepair deletion in CSPG4/NG2 abrogates protein expression, glioblastoma proliferation and invasion in vitro and in vivo in mice (2022) (0)
- Author Correction: Disulfide-compatible phage-assisted continuous evolution in the periplasmic space (2021) (0)
- Abstract SY05-04: Biological discovery and therapeutic insight from DNA-templated macrocycle libraries (2014) (0)
- This article is part of the Nucleic acids: new life, new materials (2015) (0)
- 248 Immunotherapy persister cells uncovered by dynamic single-cell RNA-sequencing (2020) (0)
- Reshaping surface proteins (2007) (0)
- Nanoparticle mediated in vitro and in vivo CRISPR base correction of LCA16 causing nonsense mutation rescues Kir7.1 channel function (2022) (0)
- Purified cytosolic crystals from Bacillus thuringiensis as a novel active pharmaceutical ingredient (API) (2022) (0)
- Src in complex with DNA-templated macrocyclic inhibitor MC25b (2012) (0)
- mutagenesis and selection A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial (2006) (0)
- Author response: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme (2018) (0)
- Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic (2016) (0)
- Development of new molecular functions (2002) (0)
- Abstract 198: DNA Base Editing in Hutchinson-Gilford Progeria Syndrome (2019) (0)
- Abstract 4350: Integrative and multiregional molecular analysis of localized, high grade prostate cancer treated with neoadjuvant androgen deprivation treatment (2018) (0)
- Towards DNA-Based Programmable Matter (2012) (0)
- Abstract 1304: Whole-exome analysis of 1,135 melanomas reveals new significantly mutated cancer genes and copy number alterations (2018) (0)
- DNA‐Templated Organic Synthesis: Nature′s Strategy for Controling Chemical Reactivity Applied to Synthetic Molecules (2004) (0)
- Evolution of a new molecular function (2002) (0)
- DNA-Templated Organic Synthesis (DTS): A Novel Approach to the Discovery of Functional Small Molecules Based on Nature′s Evolutionary Principles (2008) (0)
- Whole Exome Sequencing and Targeted Sequencing Reveal the Heterogeneity of Genomic Evolution and Mutational Profile in Smoldering Multiple Myeloma (2016) (0)
- Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocyclic Inhibitor 37 (2019) (0)
- In vivo continuous directed evolution The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2015) (0)
- Nucleic Acid‐Templated Synthesis of Sequence‐Defined Synthetic Polymers (2017) (0)
- Author Correction: Engineered pegRNAs improve prime editing efficiency (2021) (0)
- Evolution of unprecedented molekylfunktion (2002) (0)
- Chabner Colloquium: Answering the Big Questions in Cancer Research & 2016 STO Annual Meeting (Boston, MA: November 11-12, 2016) (2016) (0)
- Chabner Colloquium: Answering the Big Questions in Cancer Research & 2018 STO Annual Meeting (2018) (0)
- -glycosyltransferase C characterization of IroB, a pathogen-associated In vitro From The Cover: (2006) (0)
- Phage-assisted continuous evolution of proteases with altered substrate specificity (2017) (0)
- Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor (2014) (0)
- Effective delivery of recombinant protein into retinal cells by cationic lipid (2016) (0)
- Mammalian Cell Penetration,siRNA Transfection, and DNA Transfection by Supercharged Green Fluorescent Proteins (2009) (0)
- First Demonstration of a Carbocation-Olefin Cyclization Route to the Lanosterol Series. (1995) (0)
- In Vivo Evolution of an RNA-Based (2003) (0)
- Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis (2022) (0)
- Expanding the Genetic Code in Vitro and in Vivo (2004) (0)
- Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63 (2019) (0)
- The Development of Amplifiable and Evolvable Unnatural Molecules (2003) (0)
- Methods and compositions for the production of orthogonal tRNA pairs of aminoacyl-tRNA synthetase (2002) (0)
- ( ) charge density promote phase separation d Disordered regions with NICD-like sequence features are common in human proteome (2016) (0)
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