David R. Spring

David R. Spring's AcademicInfluence.com Rankings

David R. Spring

Chemistry

#3901

World Rank

#4948

Historical Rank

Organic Chemistry

#613

World Rank

#704

Historical Rank

chemistry Degrees

Download Badge

Chemistry

David R. Spring's Degrees

PhD Chemistry Stanford University
Bachelors Chemistry University of California, Berkeley

Why Is David R. Spring Influential?

(Suggest an Edit or Addition)

(See a Problem?)

David R. Spring's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Fluorescent chemosensors for Zn(2+). (2010) (852)
Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor. (2010) (624)
Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia (2002) (615)
Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules. (2010) (561)
Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. (2011) (522)
Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy. (2014) (376)
Diversity-oriented synthesis: producing chemical tools for dissecting biology. (2012) (310)
The molecular basis of the host response to lipopolysaccharide (2010) (309)
Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials. (2013) (295)
Peptide stapling techniques based on different macrocyclisation chemistries. (2015) (287)
Diversity-oriented synthesis; a challenge for synthetic chemists. (2003) (280)
A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells. (2013) (265)
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. (2004) (237)
Diversity-oriented synthesis; a spectrum of approaches and results. (2008) (215)
Palladium-catalysed cross-coupling of organosilicon reagents. (2012) (215)
Chemical genetics to chemical genomics: small molecules offer big insights. (2005) (202)
A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching. (2010) (192)
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria. (2012) (183)
Cleavable linkers in antibody-drug conjugates. (2019) (170)
Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach (2010) (168)
Induction-driven stabilization of the anion-π interaction in electron-rich aromatics as the key to fluoride inclusion in imidazolium-cage receptors. (2011) (149)
Coumarin-derived transformable fluorescent sensor for Zn2+. (2012) (138)
Development of off-on fluorescent probes for heavy and transition metal ions. (2010) (127)
Functionalised staple linkages for modulating the cellular activity of stapled peptides (2014) (123)
Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. (2002) (123)
Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions (2015) (121)
Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing? (2004) (106)
Anti-MRSA agent discovery using diversity-oriented synthesis. (2008) (106)
The discovery of antibacterial agents using diversity-oriented synthesis. (2009) (104)
Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe (2014) (101)
A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling. (2013) (101)
Drug discovery: A question of library design (2011) (95)
Diversity-oriented synthesis of macrocyclic peptidomimetics (2011) (95)
Rational methods for the selection of diverse screening compounds. (2011) (90)
Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities. (2006) (86)
Diversity-oriented synthesis. (2009) (84)
Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation. (2004) (82)
Skeletal diversity construction via a branching synthetic strategy. (2006) (81)
Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site (2011) (80)
A one-bead, one-stock solution approach to chemical genetics: part 2. (2001) (79)
Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. (2015) (76)
Variations on a Theme: Diverse N-Acyl Homoserine Lactone-Mediated Quorum Sensing Mechanisms in Gram-Negative Bacteria (2006) (73)
Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs). (2020) (73)
The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions (2021) (71)
Diversity-oriented synthesis as a tool for identifying new modulators of mitosis (2014) (69)
Strategies for the Diversity-Oriented Synthesis of Macrocycles. (2019) (69)
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics. (2012) (68)
Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1** (2012) (66)
How Diverse Are Diversity Assessment Methods? A Comparative Analysis and Benchmarking of Molecular Descriptor Space (2014) (64)
Site-selective modification strategies in antibody-drug conjugates. (2020) (61)
Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings (2000) (61)
Studies on the Biomimetic Synthesis of the Manzamine Alkaloids (1999) (61)
Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa. (2012) (60)
Proceedings of the Chemical Society. January 1963 (1963) (60)
Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions (2018) (59)
Discovery of a highly selective turn-on fluorescent probe for Ag+. (2010) (57)
A two-component 'double-click' approach to peptide stapling (2015) (57)
Assessment of structural diversity in combinatorial synthesis. (2005) (55)
Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene. (2011) (54)
A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium (2011) (54)
Diversity-Oriented Synthesis: Producing Chemical Tools for Dissecting Biology (2012) (54)
Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy. (2014) (52)
Fluorous tagged small molecule microarrays. (2007) (52)
Exploiting domino enyne metathesis mechanisms for skeletal diversity generation. (2008) (52)
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 (2016) (52)
Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials (2013) (50)
The oxidation of organocuprates--an offbeat strategy for synthesis. (2006) (50)
Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae (2014) (49)
Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule (2010) (49)
Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis. (1998) (49)
Total synthesis of sanguiin H-5. (2008) (48)
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase (2017) (48)
Synthesis of medium-ring and iodinated biaryl compounds by organocuprate oxidation. (2005) (47)
Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation (2014) (47)
Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection (2016) (47)
compounds with the menthol cooling effect (1978) (46)
Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis. (2008) (45)
Fluorescent Chemosensors for Zn2 (2010) (45)
Cell-cell communication in Gram-negative bacteria. (2005) (44)
Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology (2016) (43)
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues. (2011) (43)
Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp (2013) (42)
Chemical Genetics to Chemical Genomics: Small Molecules Offer Big Insights (2005) (42)
Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections (2018) (41)
Importance of relative humidity in the oxidative ageing of organic aerosols: case study of the ozonolysis of maleic acid aerosol (2011) (40)
Structure-activity relationships of Erwinia carotovora quorum sensing signaling molecules. (2005) (40)
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates† †Dedicated to Professor Jack Baldwin on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c (2018) (40)
Small-molecule screening: advances in microarraying and cell-imaging technologies. (2007) (40)
Which microbial factors really are important in Pseudomonas aeruginosa infections? (2015) (39)
Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages. (2006) (39)
A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles (2016) (38)
Is synthesis the main hurdle for the generation of diversity in compound libraries for screening? (2009) (38)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066 (2017) (38)
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer (2016) (37)
Synthesis of unprecedented scaffold diversity. (2009) (37)
2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa (2011) (37)
Learning the language of bacteria. (2007) (37)
Investigating peptide sequence variations for 'double-click' stapled p53 peptides. (2014) (36)
Diversity-oriented synthesis of bicyclic and tricyclic alkaloids. (2010) (35)
Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction. (2015) (34)
Controlling the contents of microdroplets by exploiting the permeability of PDMS. (2011) (34)
Synthesis and utilization of functionalized polystyrene resins (2005) (33)
Linear Aliphatic Dialkynes as Alternative Linkers for Double‐Click Stapling of p53‐Derived Peptides (2014) (33)
Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity. (2012) (33)
Loving the poison: the methylcitrate cycle and bacterial pathogenesis. (2018) (33)
The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles. (2012) (33)
Gemmacin B: bringing diversity back into focus. (2008) (32)
Chemical genetics. (2011) (32)
Diversity-oriented synthesis of disubstituted alkenes using masked silanols. (2010) (31)
The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations (2014) (30)
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell (2016) (30)
An approach to the manzamine alkaloids modelled on a biogenetic theory (1997) (30)
The Pseudomonas Quinolone Signal (PQS) (2016) (29)
A new Pseudomonas quinolone signal (PQS) binding partner: MexG† †Electronic supplementary information (ESI) available: Full experimental protocols and characterisation data. See DOI: 10.1039/c5sc04197j (2016) (29)
Enriching chemical space with diversity-oriented synthesis. (2006) (29)
Aryl-aryl coupling via directed lithiation and oxidation. (2005) (28)
Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules. (2010) (27)
Robust routes for the synthesis of N-acylated-L-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity (2011) (27)
Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons (2018) (26)
A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds. (2012) (26)
The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. (2015) (26)
Novel non-ATP competitive small molecules targeting the CK2 α/β interface (2018) (26)
Efficient synthesis of the sponge alkaloids cyclostellettamines A-F (1998) (25)
3D small-molecule microarrays. (2009) (25)
Towards quorum-quenching catalytic antibodies. (2009) (24)
Photocatalytic methods for amino acid modification. (2020) (24)
Fluoride-free cross coupling using vinyldisiloxanes. (2009) (23)
Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing. (2013) (23)
Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis. (2004) (23)
A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data and details of the computational analyses. See DOI: 10.1039/c5ob00371g Clic (2015) (23)
Small molecules in biology. (2011) (22)
Copper catalyzed oxidation of organozinc halides. (2006) (22)
The Synthesis of Quinolone Natural Products from Pseudonocardia sp. (2015) (22)
Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems. (2013) (22)
Sulfatase-cleavable linkers for antibody-drug conjugates† (2020) (22)
Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening. (2010) (21)
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery (2019) (21)
Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates. (2012) (20)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics (2016) (20)
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling (2016) (20)
Polyfluoroaryl organometallic compounds—XII : Nucleophilic substitution in octafluorodibenzothiophen, and related compounds (1971) (19)
Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space. (2011) (19)
The Basics of Diversity‐Oriented Synthesis (2013) (19)
Using chemical probes to investigate the sub-inhibitory effects of azithromycin. (2008) (19)
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells (2016) (19)
The reductive cleavage of picolinic amides (2016) (19)
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01270e Click here for additional data file. (2017) (19)
Stapled peptides as a new technology to investigate protein–protein interactions in human platelets† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00284c (2018) (19)
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection. (2019) (19)
Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha (2015) (18)
Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future (2018) (18)
Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters (2018) (18)
Concise Synthesis of Substituted Quinolizin‐4‐ones by Ring‐Closing Metathesis (2014) (17)
THE EVALUATION OF NON-PYROTECHNIC ALLY GENERATED AEROSOLS AS FIRE SUPPRESSANTS (2003) (17)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes (2017) (17)
Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2 (2014) (17)
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design. (2017) (17)
Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs (2012) (17)
Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls. (2011) (17)
Vinyldisiloxanes: their synthesis, cross coupling and applications. (2011) (17)
Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds (2012) (15)
A novel Diels-Alder approach to hydroisoquinolines (1998) (15)
Second-generation CK2α inhibitors targeting the αD pocket† †Electronic supplementary information (ESI) available: All experimental details, crystallographic data collection and refinement statistics, details of chemical synthesis, additional figures and tables. See DOI: 10.1039/c7sc05122k (2018) (15)
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a (2019) (14)
2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator. (2008) (14)
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides. (2019) (14)
Aryl-aryl bond formation by the fluoride-free cross-coupling of aryldisiloxanes with aryl bromides. (2011) (14)
Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers (2016) (14)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction (2017) (14)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation (2019) (14)
Ligand binding kinetics of the quorum sensing regulator PqsR. (2013) (13)
The Serratia LuxR family regulator CarR39006 activates transcription independently of cognate quorum sensing signals (2011) (13)
Mild and Efficient Synthesis of Benzo-Fused Seven- and Eight-membered Ring Lactams: A Convenient Approach to Biologically Interesting Chemotypes (2013) (13)
A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine. (2017) (13)
Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery. (2020) (13)
Efficient Synthesis of Fmoc-ProtectedAzido Amino Acids (2011) (12)
Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin (2013) (12)
A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives. (2012) (12)
High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics. (2014) (12)
Polyfluoroaryl organometallic compounds—VII : Synthesis and nucleophilic substitution in octafluorodibenzothiophen and in octafluorothianthren (1968) (12)
Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface. (2018) (11)
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design (2020) (11)
Polyfluoroaryl organometallic compounds—X : Nucleophilic substitution in octafluorofluoren-9-one (1969) (11)
Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. (2016) (11)
Diversity-Oriented Synthesis: A Spectrum of Approaches and Results (2008) (11)
Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489 (2016) (11)
Efficient and selective antibody modification with functionalised divinyltriazines. (2020) (10)
Design of Explosion Isolation Barriers (2005) (10)
Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional (2017) (10)
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells. (2020) (9)
High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays (2010) (9)
Polyfluoroaryl organometallic compounds. Part VIII. Synthesis of and nucleophilic substitution in octafluorodibenzofuran (1968) (9)
Diversity‐Oriented Synthesis of Biaryl‐Containing Medium Rings Using a One Bead/One Stock Solution Platform. (2002) (9)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa. (2017) (9)
Polyfluoroaryl organometallic compounds. Part XV. Synthesis and rearrangement of polyhalogenoaryl α-diketones (1972) (9)
Chemical probes targeting the kinase CK2: a journey outside the catalytic box. (2021) (9)
Synthesis of structurally diverse biflavonoids (2018) (9)
Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling. (2019) (8)
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42). (2017) (8)
Design and chance in the self-assembly of macromolecules. (2007) (8)
The role of chemical synthesis in developing RiPP antibiotics. (2021) (8)
An Unusual Benzyne Reaction (1969) (8)
General dual functionalisation of biomacromolecules via a cysteine bridging strategy. (2020) (8)
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides. (2019) (8)
Towards Quorum‐Quenching Catalytic Antibodies. (2009) (8)
Polyfluoroarylorganometallic compounds XIII. Pentachlorophenylpentafluorophenylmercury (1971) (7)
Bioinspired Total Synthesis of Bussealin E. (2018) (7)
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study (2021) (7)
Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis. (2015) (7)
Polyfluoroaryl organometallic compounds. Part IX. Reactions of polyfluoroaryl-lithiums with dimethyl carbonate. Octafluorofluoren-9-one (1968) (7)
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone. (2017) (7)
A dual-enzyme cleavable linker for antibody-drug conjugates. (2021) (6)
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion† (2020) (6)
The Development of a Small Scale Class A Fire Test (1997) (6)
Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file. (2017) (6)
Polyfluoroaryl organometallic compounds XIV. 5-phenyl-octafluorodibenzophosphole (1972) (6)
Second-generation CK2 alpha inhibitors targeting the alpha D pocket. (2018) (6)
Towards drugging the 'undruggable': enhancing the scaffold diversity of synthetic small molecule screening collections using diversity-oriented synthesis (2013) (6)
Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products (2018) (5)
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry. (2019) (5)
Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu (2016) (5)
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. (2020) (5)
Studies Towards the Synthesis of the Core of Endiandric Acid H (2018) (5)
Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1 (2019) (5)
Synthesis of Unprecedented Scaffold Diversity (2009) (5)
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction (2020) (5)
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics (2020) (5)
Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking. (2018) (5)
Dynamic Combinatorial Chemistry with Novel Dithiol Building Blocks: Towards New Structurally Diverse and Adaptive Screening Collections (2013) (4)
Peptide Stapling Techniques Based on Different Macrocyclization Chemistries (2015) (4)
Diversity‐Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems (2014) (4)
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent (2021) (4)
Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut—Currier Reaction. (2015) (4)
Identification of an anti‐MRSA Dihydrofolate Reductase Inhibitor from a Diversity‐Oriented Synthesis. (2009) (4)
Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation (2012) (4)
Synthesis of a Biotin-LabeledQuorum-Sensing Molecule: Towards a General Method for Target Identification (2008) (4)
Mastering the chemical language of bacteria. (2009) (4)
Non-internalising antibody-drug conjugates. (2022) (4)
CHAPTER 8:Double-click Stapled Peptides for Inhibiting Protein–Protein Interactions (2017) (3)
Rapid and robust cysteine bioconjugation with vinylheteroarenes† (2021) (3)
The Discovery of Antibacterial Agents Using Diversity‐Oriented Synthesis (2009) (3)
(Z)-Selective Takai olefination of salicylaldehydes (2017) (3)
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides. (2021) (3)
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence (2016) (3)
Fsp 3 -Rich and Diverse Fragments Inspired by Natural Products as a Collection to Enhance Fragment-Based Drug Discovery (2020) (3)
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents. (2020) (3)
An Introduction to Diversity‐Oriented Synthesis (2009) (3)
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions (2021) (3)
Synthesis of Biaryl-ContainingMedium-Ring Systems by Organocuprate Oxidation: Applications inthe Total Synthesis of Ellagitannin Natural Products (2009) (3)
Regioselectivity in ThermalRhodium(II)-Catalysed Büchner-Type Reactions of SubstitutedAryl Halides: Studies towards the Synthesis of Halide-SubstitutedCycloheptatrienes (2011) (3)
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa (2020) (2)
Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Tandem Carbocupration and Organocuprate Oxidation (2010) (2)
Aryl—Aryl Coupling via Directed Lithiation and Oxidation. (2005) (2)
Multiple‐parameter Optimization in Drug Discovery: Example of the 5‐HT1B GPCR (2016) (2)
New Advances in Diversity‐Oriented Synthesis (2015) (2)
C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection. (2020) (2)
NEW APPLICATIONS OF AQUEOUS AGENTS FOR FIRE SUPPRESSION (2)
Arene C—H Functionalization Using a Removable/Modifiable or a Traceless Directing Group Strategy (2014) (2)
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds. (2020) (2)
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol (2019) (2)
Synthesis of Sanguiin H-5 (2008) (2)
4. Diversity-Oriented Synthesis (2011) (2)
Novel Phosphate Derivativesas Scaffolds for the Preparation of Synthetic Phosphoserine-BasedPeptides Using the Fmoc/t-BuSolid-Phase Strategy (2012) (1)
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance (2023) (1)
Oxidation of Organocopper Compounds (2011) (1)
Detection of fires and explosions (1978) (1)
Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae (2014) (1)
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors (2022) (1)
Diversity oriented synthesis: a challenge for synthetic chemists. (2006) (1)
Novel Phosphate Derivatives as Scaffolds for the Preparation of Synthetic Phosphoserine-Based Peptides Using the Fmoc / t-Bu Solid-Phase Strategy (2012) (1)
The crystal structure of CK2alpha in complex with an analogue of compound 22 (2018) (1)
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (2022) (1)
synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with a-iminocarbenes † (2017) (1)
Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes (2021) (1)
Chemical library screening approaches to aid the design of protein- protein inhibitors (2013) (1)
C-H activation: Complex peptides made simple. (2016) (1)
Diversity‐Oriented Synthesis of Disubstituted Alkenes Using Masked Silanols. (2010) (1)
PNA to DNA to microarray decoding facilitates ligand discovery. (2011) (1)
An Infrared Flame Detector With Fire-Ranging Ability (1987) (1)
EVALUATION OF ALTERNATIVE AGENTS FOR SUPPRESSION OF FUEL SPRAY EXPLOSIONS IN MILITARY VEHICLE CREW COMPARTMENTS (1999) (1)
GLP-1R is downregulated in beta cells of NOD mice and T1D patients (2019) (1)
Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol. (2018) (1)
Chapter 2:The Application of Diversity-oriented Synthesis in Chemical Biology (2018) (1)
The crystal structure of CK2alpha in complex with compound 3 (2018) (0)
The crystal structure of CK2alpha in complex with compound 11 (2018) (0)
Importin-alpha in complex with HNF1-beta peptide (2016) (0)
Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122 (2016) (0)
The crystal structure of CK2alpha in complex with compound 22 (2018) (0)
The crystal structure of CK2alpha in complex with compound 30 (2018) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide (2012) (0)
Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability (2022) (0)
Hotspots API: a toolkit for the application of fragment hotspot mapping to structure-based drug discovery (2019) (0)
Effects of aerosol phase and water uptake for understanding organic aerosol oxidation (2012) (0)
new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoa ffi nity probes † (2017) (0)
The crystal structure of CK2alpha in complex with compound 14 (2018) (0)
Induction of quorum sensing in microdroplets by transporting small molecule through PDMS (2010) (0)
Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound (2017) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LHSpTA peptide. (2018) (0)
Fluoride-Free Cross-Coupling Using Vinyldisiloxanes. (2009) (0)
The crystal structure of CK2alpha in complex with compound 31 (2018) (0)
Structure of the Stapled Peptide Bound to Mdm2 (2016) (0)
The crystal structure of CK2alpha in complex with compound 24 (2018) (0)
Crystal structure of Ck2alpha with ZT0633 bound (2017) (0)
Crystal Structure of CK2alpha (2016) (0)
Progress towards the development of a new strategy for the highly stereoselective synthesis of alkene-containing macrocyclic ring sys- tems by organocuprate oxidation Avenços en el desenvolupament d'una nova estratègia per a la síntesi altament estereoselectiva de sistemes macrocíclics que contenen (2013) (0)
The Reductive Cleavage of Picolinic Amides. (2016) (0)
Structure of mature activin A with small molecule 2 (2021) (0)
1 THE BASICS OF DIVERSITY-ORIENTED SYNTHESIS (2013) (0)
Novel and Efficient Copper‐Catalyzed Synthesis of Nitrogen‐Linked Medium‐Ring Biaryls. (2011) (0)
The Oxidation of Organocuprates — An Offbeat Strategy for Synthesis (2006) (0)
Crystal Structure of CK2alpha with compound 10 bound (2016) (0)
Mild and Efficient Synthesis of Benzo‐Fused Seven‐ and Eight‐Membered Ring Lactams: A Convenient Approach to Biologically Interesting Chemotypes. (2013) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with JES107 (2018) (0)
tion via alkyne hydrosilylation using a substoichiometric amount of ruthenium ( II ) catalyst † ‡ (2017) (0)
Supplemental Information Overcoming Chemical , Biological , and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions (0)
Efficient Synthesis of the Sponge Alkaloids Cyclostellettamines A‐F. (1999) (0)
Zn2+-triggered amide tautomerization produces a highly Zn2+-selective fluorescent sensor (2019) (0)
Crystal Structure of CK2alpha with N-((2-chloro-[1,1'-biphenyl]-4-yl)methyl)butane-1,4-diamine bound (2017) (0)
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA) (2020) (0)
Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents (2023) (0)
The crystal structure of CK2alpha in complex with CAM4712 and compound 37 (2018) (0)
Progress towards the development of a new strategy for the highly stereoselective synthesis of alkene-containing macrocyclic ring systems by organocuprate oxidation (2013) (0)
The crystal structure of CK2alpha in complex with compound 27 (2018) (0)
Aryl—Aryl Bond Formation by the Fluoride-Free Cross-Coupling of Aryldisiloxanes with Aryl Bromides. (2012) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with Alpha-Bromo-3-Iodotoluene. (2018) (0)
Small molecules in biology themed issue (2011) (0)
Crystal structure of CK2alpha with 3-(3-chloro-4-(phenyl)benzylamino)propan-1-ol bound (2016) (0)
1‐(3,5‐Dinitrobenzoyl)‐4‐methylpiperazine (2011) (0)
An agent for inducing a physiological cooling effect on the skin or mucous membranes of the human body. (1973) (0)
Some aspects of fluorocarbanion chemistry (1968) (0)
The crystal structure of CK2alpha in complex with compound 25 (2018) (0)
Consumable product with physiological kuehlwirkung (1974) (0)
Nucleophilic substitution in octafluoro-9-fluorenone (1968) (0)
Means with physiological kuehlwirkung (1974) (0)
Adventures in Drugging Undruggable Targets (2018) (0)
Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates (2018) (0)
Diversity-oriented synthesis of macrocyclic (2011) (0)
United States Patent ( 19 ) Watson et al . ( 54 ) N-SUBSTITUTED PARAMENTHANE (2017) (0)
Towards Diversity-Oriented Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings. (2000) (0)
Vinyldisiloxanes: Their Synthesis, Cross-Coupling and Applications. (2011) (0)
Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122 (2016) (0)
A Novel Diels—Alder Approach to Hydroisoquinolines. (1998) (0)
The Crystal structure of CK2a bound to P1-C4 (2019) (0)
Diversity‐Oriented Synthesis of Drug‐Like Macrocyclic Scaffolds Using an Orthogonal Organo‐ and Metal Catalysis Strategy. (2015) (0)
Editorial: the chemistry-biology interface. (2008) (0)
Structure of mature activin A with small molecule 42 (2021) (0)
Peroxide-cleavable linkers for antibody–drug conjugates (2023) (0)
The crystal structure of CK2alpha in complex with analogues of compound 1 (2018) (0)
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy (2022) (0)
Crystal structure of P8C9 bound to CK2alpha (2021) (0)
The Crystal structure of CK2a bound to P2-C4 (2019) (0)
Crystal structure of Mdm2 bound to a stapled peptide (2019) (0)
A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase (2023) (0)
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action (2022) (0)
Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase (2023) (0)
PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with NM466-1 (2020) (0)
PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-45 (2020) (0)
Aurora A Kinase in complex with ATP in space group P41212 (2016) (0)
Studies Towards the Synthesis of the Core of Endiandric Acid H (2018) (0)
The crystal structure of CK2alpha in complex with compound 32 (2018) (0)
Palladium-Catalyzed Cross-Coupling of Organosilicon Reagents (2012) (0)
Which microbial factors really are important in Pseudomonas 1 aeruginosa infections ? 2 3 (2015) (0)
The crystal structure of CK2alpha in complex with compound 29 (2018) (0)
Assessment of Structural Diversity in Combinatorial Synthesis (2005) (0)
The crystal structure of CK2alpha in complex with compound 33 (2018) (0)
Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122 (2016) (0)
Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling (2019) (0)
Crystal Structure of CK2alpha with CAM187 bound (2018) (0)
Aurora A Kinase in Complex with ATP in Space Group P6122 (2016) (0)
PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with SK-430 (2020) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) (2018) (0)
Stereoselective Synthesis ofDisubstituted Butadienes via Copper-Mediated Coupling of AlkenylSilanes (2011) (0)
Concise Copper‐Catalyzed Synthesis of Tricyclic Biaryl Ether‐Linked Aza‐Heterocyclic Ring Systems. (2014) (0)
PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-42 (2020) (0)
Palladium‐Catalyzed Cross‐Coupling of Vinyldisiloxanes with Benzylic and Allylic Halides and Sulfonates. (2012) (0)
PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with NM450-1 (2020) (0)
1-(2-chloro-[1,1'-biphenyl]-4-yl)-N-methylethanamine (2017) (0)
The structure of the polo-box domain (PBD) of Plk1 in complex with Z228588490 (2018) (0)
The crystal structure of CK2alpha in complex with CAM4712 (2018) (0)
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023) (2023) (0)
PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-43 (2020) (0)
Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoat bound (2016) (0)
Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound (2016) (0)
Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site (2011) (0)
Development of small cyclic peptides targeting the CK2α/β interface (2022) (0)
Crystal Structure of CK2alpha with ZT0432 bound (2017) (0)
Abstracts of the 27th International Isotope Society (UK group) symposium: Synthesis and applications of labelled compounds 2018 (2019) (0)
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading (2022) (0)
Aurora A in complex with ATP and AA35. (2016) (0)
Title Efficient development of stable and highly functionalised peptides targeting the CK 2 / CK 2 protein – protein interaction (2019) (0)
Crystal structure of CK2alpha with ZT0583 bound. (2017) (0)
Crystal Structure of CK2alpha with 3,4-dichlorophenethylamine bound (2016) (0)
A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic sca ff olds † (2015) (0)
CK 2 a inhibitors targeting the a D pocket † (2018) (0)
Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation. (2012) (0)
Synthesis of Highly Substituted Symmetrical 1,3‐Dienes via Tandem Carbocupration and Organocuprate Oxidation. (2011) (0)
Crystal Structure of CK2alpha with a novel closed conformation of the aD loop (2016) (0)
Copper‐Catalyzed Oxidation of Organozinc Halides. (2007) (0)
Concise Synthesis of Substituted Quinolizin-4-ones by Ring-Closing Metathesis. (2015) (0)
Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122 (2016) (0)
Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound (2016) (0)
Stereoselective Synthesis of Disubstituted Butadienes via Copper-Mediated Coupling of Alkenyl Silanes (2011) (0)
Highlights from the 39th ESF/EUCHEM Conference on Stereochemistry, Brgenstock, Switzerland, April 2004 (2004) (0)
Formation of flavone-based wooly fibres by glandular trichomes of Dionysia tapetodes (2020) (0)
The crystal structure of CK2alpha in complex with compound 18 (2018) (0)
The crystal structure of CK2alpha in complex with compound 20 (2018) (0)
The structure of the polo-box domain (PBD) of Plk1 in complex with Alpha-Bromo-3-Iodotoluene. (2018) (0)
Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122 (2016) (0)
Crystal structure of CK2alpha with ZT0627 bound (2017) (0)
Crystal Structure of CK2alpha with Compound 7 bound (2017) (0)
Regioselectivity in Thermal Rhodium ( II )-Catalysed Büchner-Type Reactions of Substituted Aryl Halides : Studies towards the Synthesis of Halide-Substituted Cycloheptatrienes (2011) (0)
Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound (2016) (0)
Induction-Driven Stabilization of the Anion–p Interaction in Electron-Rich Aromatics as the Key to Fluoride Inclusion in Imidazolium-Cage ACHTUNGTRENNUNG eceptors (2011) (0)
Erratum: Structure of a blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding site (Structure (2011) 19 (1691-1700)) (2011) (0)
LGR5 targeting molecules as therapeutic agents for multiple cancer types (2022) (0)
Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122 (2016) (0)

This paper list is powered by the following services:

Other Resources About David R. Spring

www-spring.ch.cam.ac.uk

What Schools Are Affiliated With David R. Spring?

David R. Spring is affiliated with the following schools:

University of California, Berkeley
University of Oxford
Stanford University
University of Cambridge
Harvard University

David R. Spring's Academic­Influence.com Rankings