David Simha Segal
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David Simha Segalbiology Degrees
Biology
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#13316
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Molecular Biology
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#1447
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Neuroscience
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#1563
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Biology
David Simha Segal's Degrees
- PhD Neuroscience University of California, Berkeley
- Masters Psychology Stanford University
Why Is David Simha Segal Influential?
(Suggest an Edit or Addition)David Simha Segal's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness. (1976) (800)
- Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine (1997) (610)
- Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. (1974) (597)
- Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis (1989) (411)
- Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways (1976) (310)
- Exposure of Adolescent Rats to Oral Methylphenidate: Preferential Effects on Extracellular Norepinephrine and Absence of Sensitization and Cross-Sensitization to Methamphetamine (2002) (308)
- Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine. (2001) (260)
- In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment (1992) (201)
- Repeated cocaine administration induces behavioral sensitization and corresponding decreased extracellular dopamine responses in caudate and accumbens (1992) (198)
- Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. (2000) (195)
- Individual differences in responsiveness to single and repeated amphetamine administration: behavioral characteristics and neurochemical correlates. (1987) (181)
- Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats (1987) (163)
- Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder. (1974) (153)
- Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse (2001) (137)
- Repeated binge exposures to amphetamine and methamphetamine: behavioral and neurochemical characterization. (1997) (131)
- Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine. (1992) (129)
- Behavioral characterization of d- and l-amphetamine: neurochemical implications (1975) (129)
- Regional extracellular norepinephrine responses to amphetamine and cocaine and effects of clonidine pretreatment (1994) (125)
- Amphetamine and its analogs : psychopharmacology, toxicology, and abuse (1994) (124)
- An Escalating Dose “Binge” Model of Amphetamine Psychosis: Behavioral and Neurochemical Characteristics (1997) (122)
- beta-Endorphin: endogenous opiate or neuroleptic? (1977) (122)
- Stimulant Actions in Rodents: Implications for Attention-Deficit/Hyperactivity Disorder Treatment and Potential Substance Abuse (2005) (119)
- Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge (2003) (117)
- Naloxone alters locomotion and interaction with environmental stimuli. (1979) (109)
- Naloxone augments electrophysiological signs of selective attention in man (1983) (101)
- Differential effects of Para-chlorophenylalanine on amphetamine-induced locomotion and stereotypy (1976) (99)
- Lack of effect on naloxone on schizophrenic symptoms. (1977) (97)
- Behavioral activation of rats during intraventricular infusion of norepinephrine. (1970) (96)
- Effect of intraventricular infusion of dopamine and norepinephrine on motor activity. (1972) (94)
- Effects of Frequency and Pattern of Medial Forebrain Bundle Stimulation on Caudate Dialysate Dopamine and Serotonin (1992) (92)
- Thyroid State: Effects on Pre-and Postsynaptic Central Noradrenergic Mechanisms (1972) (91)
- Dissociation between in vivo hippocampal norepinephrine response and behavioral/neuroendocrine responses to noise stress in rats (1992) (90)
- Apparent tolerance to some aspects of amphetamine stereotypy with long-term treatment (1980) (86)
- Metabolic and experiential factors in the behavioral response to repeated amphetamine (1977) (86)
- Shock-induced aggression: opposite effects of intraventricularly infused dopamine and norepinephrine. (1974) (79)
- Tyrosine hydroxylase activity: regional and subcellular distribution in the brain. (1974) (77)
- Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptors (1999) (72)
- Effects of Long-Term Reserpine Treatment on Brain Tyrosine Hydroxylase and Behavioral Activity (1971) (72)
- Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments (1997) (72)
- Acute and chronic behavioral interactions between phencyclidine (PCP) and amphetamine: Evidence for a dopaminergic role in some PCP-induced behaviors (1985) (69)
- Multiple daily amphetamine administration: behavioral and neurochemical alterations. (1980) (68)
- Cycloheximide: Its Effects on Activity Are Dissociable from Its Effects on Memory (1971) (68)
- Correlation of brain levels of drugs with behavioral effects. (1969) (68)
- Blunted prolactin response. A neuroendocrine abnormality manifested by depressed patients. (1982) (67)
- Reserpine enhances amphetamine stereotypies without increasing amphetamine-induced changes in striatal dialysate dopamine (1989) (67)
- Regional quantification of D1, D2, and D3 dopamine receptor mRNA in rat brain using a ribonuclease protection assay. (1995) (67)
- Naloxone-induced behavioral and physiological effects in normal and manic subjects. (1980) (66)
- Stimulant-induced psychosis: an evaluation of animal methods. (1981) (66)
- Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization (2005) (65)
- Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity. (1975) (63)
- Differential effects of D- and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesis. (1975) (63)
- Stress produces opioid-like effects on investigatory behavior (1985) (62)
- Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high‐dose methamphetamine binge (2006) (61)
- The effects of environmental isolation on behavior and regional rat brain tyrosine hydroxylase and tryptophan hydroxylase activities. (1973) (59)
- Regional norepinephrine response to amphetamine using dialysis: Comparison with caudate dopamine (1992) (59)
- Antidromically identified striatonigral projection neurons in the chronically implanted behaving rat: relations of cell firing to amphetamine-induced behaviors. (1989) (56)
- Dose-dependent biphasic alterations in the spontaneous activity of neurons in the rat neostriatum produced by D-amphetamine and methylphenidate (1978) (56)
- Behavioral and neurochemical correlates of repeated d-amphetamine administration. (1975) (56)
- Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response. (1997) (56)
- Multiple Daily Amphetamine Administration: Behavioral and Neurochemical Alterations (1980) (54)
- NALOXONE EFFECTS ON MANIC SYMPTOMS AND GROWTH-HORMONE LEVELS (1978) (54)
- Behavioral and neurochemical characteristics of stimulant-induced augmentation. (1987) (53)
- Alterations in behaviour and catecholamine biosynthesis induced by lithium (1975) (53)
- Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration? (1995) (52)
- Dopamine transporter mRNA is up-regulated in the substantia nigra and the ventral tegmental area of amphetamine-sensitized rats (1997) (49)
- Comparison of opiate- and opioid-peptide-induced immobility. (1979) (49)
- Characteristics of β-endorphin-induced behavioral activation and immobilization (1979) (49)
- Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile. (1999) (48)
- Strain differences in behavior and brain tyrosine hydroxylase activity. (1972) (46)
- Repeated amphetamine pretreatment alters the responsiveness of striatal dopamine-stimulated adenylate cyclase to amphetamine-induced desensitization. (1987) (46)
- Human Methamphetamine Pharmacokinetics Simulated in the Rat: Single Daily Intravenous Administration Reveals Elements of Sensitization and Tolerance (2006) (45)
- INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY 1 (1974) (44)
- Des-tyrosine -γ-endorphin and haloperidol: Behavioral and biochemical differentiation (1979) (44)
- Increased startle responding in rats treated with phencyclidine. (1984) (44)
- The behavioral effects of depletions of brain serotonin induced by 5,7-dihydroxytryptamine vary with time after administration. (1986) (43)
- An Escalating Dose/Multiple High-Dose Binge Pattern of Amphetamine Administration Results in Differential Changes in the Extracellular Dopamine Response Profiles in Caudate-Putamen and Nucleus Accumbens (1997) (43)
- l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine. (1999) (42)
- Apomorphine Does Not Alter Amphetamine‐Induced Dopamine Release Measured in Striatal Dialysates (1990) (40)
- Lithium differentially antagonizes self-stimulation facilitated by morphine and (+)-amphetamine (1976) (40)
- Deprenyl alters behavior and caudate dopamine through an amphetamine-like action (1992) (40)
- Individual behavioral and neuroendocrine differences in responsiveness to audiogenic stress (1989) (39)
- Repeated amphetamine and fencamfamine: sensitization and reciprocal cross-sensitization. (1990) (38)
- Naloxone increases electrophysiological measures of selective information processing in humans (1984) (38)
- Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptors. (1999) (37)
- In vivo measures of monoamines during amphetamine-induced behaviors in rats (1990) (36)
- Low alcohol alternatives: a promising strategy for reducing alcohol related harm. (2009) (36)
- Caudate–putamen dopamine and stereotypy response profiles after intravenous and subcutaneous amphetamine (1999) (36)
- Escalating dose-binge stimulant exposure: relationship between emergent behavioral profile and differential caudate-putamen and nucleus accumbens dopamine responses (1999) (36)
- Maintenance of amphetamine-induced stereotypy and locomotion requires ongoing dopamine receptor activation (1997) (33)
- Propranolol-induced rapid activation of rat striatal tyrosine hydroxylase concomitant with behavioral depression. (1972) (33)
- Evidence for an interaction of opioid and noradrenergic locus coeruleus systems in the regulation of environmental stimulus-directed behavior (1981) (30)
- Ventricular infusion of norepinephrine and amphetamine: direct versus indirect action. (1974) (29)
- HUMAN METHAMPHETAMINE PHARMACOKINETICS SIMULATED IN THE RAT: BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF A 72- HOUR BINGE (2009) (29)
- Methamphetamine-induced alteration in the physical state of rat caudate tyrosine hydroxylase. (1972) (29)
- Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient rats (2003) (29)
- Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidate (1999) (29)
- Amphetamine-induced changes in behavior and caudate extracellular acetylcholine (1992) (28)
- Differential Regulation of Immediate-Early Gene Expression in the Prefrontal Cortex of Rats with a High vs Low Behavioral Response to Methamphetamine (2006) (28)
- Differential effects of morphine andd-amphetamine on self-stimulation from closely adjacent regions in rat midbrain (1977) (26)
- Behavioral alterations induced by an escalating dose-binge pattern of cocaine administration (1997) (24)
- Depletion of brain serotonin by 5,7-dihydroxytryptamine alters the response to amphetamine and the habituation of locomotor activity in rats (2004) (24)
- The effect of methadone on the behavioral and neuroendocrine responses of manic patients (1982) (23)
- Characterization of the endorphins, novel hypothalamic and neurohypophysial peptides with opiate-like activity: evidence that they induce profound behavioral changes (1977) (23)
- Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats (2007) (23)
- Hippocampal glucocorticoid receptor mRNA is up-regulated by acute and down-regulated by chronic amphetamine treatment. (1996) (22)
- beta-endorphin: cellular localization, electrophysiological and behavioral effects. (1978) (22)
- Clorgyline-induced increases in presynaptic DA: Changes in the behavioral and neurochemical effects of amphetamine using in vivo microdialysis (1992) (22)
- Evidence that a behavioral augmentation following repeated amphetamine administration does not involve peripheral mechanisms (1982) (21)
- Behavioral effects of xylamine-induced depletions of brain norepinephrine: Interaction with amphetamine (1986) (20)
- NEGATIVE NALOXONE EFFECTS ON SERUM-PROLACTIN (1978) (20)
- Neurochemical and behavioral effects of clonidine and related imidazolines: interaction with alpha-adrenoceptors. (1978) (20)
- The effects of phencyclidine on spontaneous aggressive behavior in the rat. (1984) (18)
- Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid (2004) (17)
- Audiogenic stress response: Behavioral characteristics and underlying monoamine mechanisms (2005) (17)
- Behavioral effects of methadone in schizophrenic patients. (1981) (16)
- Regional quantification of dopamine transporter mRNA in rat brain using a ribonuclease protection assay (1995) (16)
- Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation. (1976) (16)
- Endorphins in Cerebrospinal Fluid (1980) (16)
- Behavioral activating effects of opiates and opioid peptides. (1980) (15)
- NONSTRIATAL DOPAMINE MECHANISMS IN THE RESPONSE TO REPEATED D-AMPHETAMINE ADMINISTRATION (1979) (15)
- Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine binges (2001) (14)
- Lack of behavioral evidence for dopamine autoreceptor subsensitivity after acute electroconvulsive shock (1982) (13)
- QUANTIFICATION OF DOPAMINE D1 AND D2 RECEPTOR mRNA LEVELS ASSOCIATED WITH THE DEVELOPMENT OF BEHAVIORAL SENSITIZATION IN AMPHETAMINE TREATED RATS (1997) (13)
- Differential regional zif268 messenger RNA expression in an escalating dose/binge model of amphetamine-induced psychosis (2000) (13)
- Differential effects of reserpine and alpha-methyl-p-tyrosine on norepinephrine and dopamine induced behavioral activity (1973) (12)
- Some Macromolecular Mechanisms in CNS Neurotransmitter Pharmacology and Their Psychobiological Organization (1972) (12)
- Alterations in β-endorphin-induced locomotor activity in morphine-tolerant rats (1980) (12)
- Metabolic Adaptation to Antidepressant Drugs: Implications for Pathophysiology and Treatment in Psychiatry (1975) (11)
- Neurobiology of Cerebrospinal Fluid 2 (1983) (11)
- Unresponsiveness of catatonic symptoms to naloxone. (1978) (10)
- Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats (2004) (9)
- Differential Effects of Serotonin Depletion on Amphetamine-Induced Locomotion and Stereotypy (1977) (8)
- Behavioral effects of opioid receptor antagonists in psychopathologic states. (1983) (8)
- Negative naloxone effects in schizophrenic patients (1977) (8)
- Effects of long-term administration of haloperidol on electrophysiologic properties of rat mesencephalic neurons. (1990) (7)
- Alterations in neostriatum tyrosine hydroxylase activity and behavior induced by electrical stimulation of the substantia nigra (1975) (7)
- Amphetamine-induced changes in nigrostriatal terminal excitability are modified following repeated amphetamine pretreatment (1996) (6)
- Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration (1979) (6)
- Stimulus control during chronic reduction of cholinesterase activity. (1971) (5)
- Effect of chronic administration of p-chlorophenylalanine on sexual receptivity of the female rat (2004) (5)
- Behavioral and neuroendocrine effects of opioid receptor agonists in psychopathologic states. (1983) (4)
- Multiple daily amphetamine administration decreases both [3H]agoinst and [3]antagonist dopamine receptor binding (1982) (4)
- Stimulatory effects of pemoline and cyclopropylpemoline on continuous avoidance behavior: similarity to effects of D-amphetamine. (1967) (4)
- Alterations in beta-endorphin-induced locomotor activity in morphine-tolerant rats. (1980) (3)
- The effects of chronic mescaline administration on operant behavior in the pigeon. (1976) (3)
- Pre- and post-junctional supersensitivity: Differentiation by intraventricular infusions of norepinephrine and methoxamine (1976) (3)
- 3 – Affective Disorders (1976) (2)
- Behavioral effects of opioid peptides:implications for future clinical research (1979) (2)
- Escalating Dose-Binge Exposure to Amphetamine and Methamphetamine: Behavioral and Neurochemical Characterization (2001) (2)
- Sequential changes in behavior induced by continuous infusions of amphetamine in rats (2004) (2)
- "Maḥberet Nəʾum ʾAšer Ben Yəhudah" of Solomon Ibn Saqbel: A Study of Scriptural Citation Clusters@@@"Mahberet Neum Aser Ben Yehudah" of Solomon Ibn Saqbel: A Study of Scriptural Citation Clusters (1982) (2)
- The effects of naloxone on methylphenidate-induced mood and behavioral changes: A negative study (1980) (2)
- 5 – The Hyperactive Child Syndrome (1976) (1)
- S-43-3 Behavioral neurotransmitter responses to a “binge” pattern of amphetamine administration (1996) (1)
- Naloxone-lnduced Lethargy-Reply (1981) (1)
- Identifying candidate genes for mania and psychosis using a convergent functional genomics approach (2000) (0)
- 1 – Introduction to Fundamental Concepts (1976) (0)
- Some considerations regarding the characterization and interpretation of neuropeptide-induced behavioral changes. (1978) (0)
- psychosis: a convergent functional genomics approach Identifying a series of candidate genes for mania and (2005) (0)
- On Certain Delights of The Book of Delight by Joseph Ben Meir Ibn Zabara: An Examination of "The Tale of the Eunuch and the Wise Daughter of a Countryman" (1977) (0)
- Proceedings: Metabolic adaptation to antidepressant drugs--a neurochemical paradox. (1974) (0)
- Amphetamine-induced behavior and dopamine release following reserpine (1989) (0)
- Foundations of Biochemical Psychiatry (2013) (0)
- Is the stereotypy response profile to psychoactive stimulant related to the magnitude of caudate dopaminergic activity (1991) (0)
- A convergent functional genomics approach identifies GRK3 as a candidate gene for bipolar disordr on 22q (2000) (0)
- Points from Letters: Agoraphobia (1975) (0)
- Psychobiological foundations of behaviors induced by amphetamines. (1984) (0)
- Methadone effects in affect disorder and schizophrenia (1981) (0)
- Des-tyrosine1-gamma-endorphin and haloperidol: behavioral and biochemical differentiation. (1979) (0)
- 106. Candidate gene transcripts involved in amphetamine-induced behavior (1998) (0)
- Caudate and accumbens dopamine response to stimulants (1992) (0)
- 9 – Hallucinogens: phencyclidine (1985) (0)
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What Schools Are Affiliated With David Simha Segal?
David Simha Segal is affiliated with the following schools:
