David. V. Schaffer
#134,941
Most Influential Person Now
David. V. Schaffer's AcademicInfluence.com Rankings
David. V. Schafferengineering Degrees
Engineering
#4807
World Rank
#6028
Historical Rank
Bioengineering
#48
World Rank
#50
Historical Rank
Biomedical Engineering
#326
World Rank
#335
Historical Rank
David. V. Schafferbiology Degrees
Biology
#9171
World Rank
#12341
Historical Rank
Neuroscience
#1320
World Rank
#1365
Historical Rank
Download Badge
Engineering Biology
David. V. Schaffer's Degrees
- PhD Bioengineering University of California, Berkeley
- Bachelors Bioengineering University of California, Berkeley
Why Is David. V. Schaffer Influential?
(Suggest an Edit or Addition)David. V. Schaffer's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Substrate modulus directs neural stem cell behavior. (2008) (1021)
- A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons (2016) (809)
- Engineering adeno-associated viruses for clinical gene therapy (2014) (629)
- Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity (2005) (617)
- The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells. (2009) (580)
- Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo (2003) (555)
- In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous (2013) (548)
- Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. (2000) (486)
- Directed evolution of adeno-associated virus yields enhanced gene delivery vectors (2006) (482)
- PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation (2007) (402)
- Biophysical regulation of epigenetic state and cell reprogramming. (2013) (385)
- The AAV Vector Toolkit: Poised at the Clinical Crossroads. (2012) (341)
- Viral Vectors for Gene Therapy: Translational and Clinical Outlook. (2015) (339)
- Optogenetic protein clustering and signaling activation in mammalian cells (2013) (338)
- Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo (2003) (313)
- A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation (2013) (278)
- Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. (2009) (267)
- X‐Space MPI: Magnetic Nanoparticles for Safe Medical Imaging (2012) (241)
- Single-cell western blotting (2014) (241)
- Transforming Growth Factor‐β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells (2010) (232)
- Nox2 redox signaling maintains essential cell populations in the brain (2010) (231)
- Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses (2009) (223)
- Designing synthetic materials to control stem cell phenotype. (2007) (223)
- Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo (2016) (214)
- Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast (2015) (214)
- Biogenic Gas Nanostructures as Ultrasonic Molecular Reporters (2014) (205)
- Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling (2012) (200)
- Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. (2007) (195)
- Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells (2011) (191)
- Adeno-associated virus effectively mediates conditional gene modification in the brain (2002) (190)
- CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window (2018) (181)
- A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells (2009) (181)
- Molecular evolution of adeno-associated virus for enhanced glial gene delivery. (2009) (176)
- Intravitreal injection of AAV2 transduces macaque inner retina. (2011) (176)
- Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. (2011) (173)
- DNA shuffling of adeno-associated virus yields functionally diverse viral progeny. (2008) (168)
- Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer (2007) (161)
- Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells (2004) (160)
- Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues. (2010) (158)
- Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging. (2014) (154)
- Directed evolution of adeno-associated virus to an infectious respiratory virus (2009) (151)
- Molecular engineering of viral gene delivery vehicles. (2008) (149)
- Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. (2008) (146)
- Optimization of Cell Surface Binding Enhances Efficiency and Specificity of Molecular Conjugate Gene Delivery* (1998) (142)
- The sonic hedgehog signaling system as a bistable genetic switch. (2004) (141)
- Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. (2012) (139)
- Directed evolution of novel adeno-associated viruses for therapeutic gene delivery (2012) (136)
- Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates (2014) (131)
- PEG conjugation moderately protects adeno-associated viral vectors against antibody neutralization. (2005) (129)
- Signal dynamics in Sonic hedgehog tissue patterning (2006) (126)
- Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells. (2012) (126)
- In vivo genome editing improves motor function and extends survival in a mouse model of ALS (2017) (120)
- Adeno-associated virus (AAV) vectors in cancer gene therapy. (2016) (117)
- Antiviral RNAi therapy: emerging approaches for hitting a moving target (2005) (114)
- At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior. (2017) (114)
- Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants (2010) (113)
- Characterization of integrin engagement during defined human embryonic stem cell culture (2010) (112)
- AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa. (2011) (112)
- Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. (2007) (111)
- The delivery challenge: fulfilling the promise of therapeutic genome editing (2020) (110)
- Control of Stochastic Gene Expression by Host Factors at the HIV Promoter (2009) (107)
- Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells. (2002) (107)
- Targeted retrograde gene delivery for neuronal protection. (2002) (105)
- Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. (2016) (104)
- Adeno-Associated Virus Vectors and Neurological Gene Therapy (2015) (104)
- Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve (2013) (101)
- HIV Promoter Integration Site Primarily Modulates Transcriptional Burst Size Rather Than Frequency (2010) (101)
- Engineering biomaterial systems to enhance viral vector gene delivery. (2011) (100)
- Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal (2015) (97)
- Multivalent ligands to control stem cell behaviour in vitro and in vivo (2013) (95)
- Extensive Determination of Glycan Heterogeneity Reveals an Unusual Abundance of High Mannose Glycans in Enriched Plasma Membranes of Human Embryonic Stem Cells* (2011) (92)
- Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications. (2016) (92)
- Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides. (2010) (91)
- Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. (2015) (90)
- Orthogonal control of expression mean and variance by epigenetic features at different genomic loci (2015) (89)
- An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells. (2011) (86)
- Engineering biomaterials for synthetic neural stem cell microenvironments. (2008) (81)
- Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. (2017) (81)
- CRISPR-mediated Activation of Latent HIV-1 Expression. (2016) (81)
- Engineering strategies to emulate the stem cell niche. (2010) (78)
- Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering (2015) (77)
- Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: A model system to study neurotoxicity in Alzheimer's disease (2014) (77)
- Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene delivery vehicles (2006) (75)
- CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. (2016) (74)
- Surface creasing instability of soft polyacrylamide cell culture substrates. (2010) (74)
- Age‐Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis (2015) (74)
- Retinoschisin gene therapy in photoreceptors, Müller glia, or all retinal cells in the Rs1h−/− mouse (2014) (74)
- Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. (2007) (73)
- Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9 (2011) (73)
- Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity (2011) (73)
- Computational Models of the Notch Network Elucidate Mechanisms of Context-dependent Signaling (2009) (72)
- The AAV vector toolkit: poised at the clinical crossroads. (2012) (72)
- Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities (2014) (71)
- Computational Design of Antiviral RNA Interference Strategies That Resist Human Immunodeficiency Virus Escape (2005) (70)
- Network News: Innovations in 21st Century Systems Biology (2011) (68)
- Advances in AAV vector development for gene therapy in the retina. (2014) (67)
- CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model (2019) (67)
- Biophysics and dynamics of natural and engineered stem cell microenvironments (2010) (66)
- Dynamics of Mechanosensitive Neural Stem Cell Differentiation (2017) (66)
- Thermoreversible Hyaluronic Acid‐PNIPAAm Hydrogel Systems for 3D Stem Cell Culture (2018) (64)
- AAV ANCESTRAL RECONSTRUCTION LIBRARY ENABLES SELECTION OF BROADLY INFECTIOUS VIRAL VARIANTS (2015) (64)
- Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery (2017) (64)
- Theoretical Design of a Gene Therapy To Prevent AIDS but Not Human Immunodeficiency Virus Type 1 Infection (2003) (62)
- Varying virulence: epigenetic control of expression noise and disease processes. (2011) (62)
- In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ. (2018) (62)
- Changes in adeno-associated virus-mediated gene delivery in retinal degeneration. (2010) (60)
- AAV-Mediated, Optogenetic Ablation of Müller Glia Leads to Structural and Functional Changes in the Mouse Retina (2013) (58)
- Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons. (2008) (57)
- Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System (2017) (56)
- Selection of Novel Vesicular Stomatitis Virus Glycoprotein Variants from a Peptide Insertion Library for Enhanced Purification of Retroviral and Lentiviral Vectors (2006) (55)
- Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency. (2008) (54)
- High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform (2016) (52)
- Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography. (2007) (52)
- Spatial organization of cell-adhesive ligands for advanced cell culture (2013) (52)
- Development of a Low Bias Method for Characterizing Viral Populations Using Next Generation Sequencing Technology (2010) (51)
- CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. (2019) (51)
- Engineering the AAV capsid to evade immune responses. (2019) (49)
- HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. (2008) (48)
- Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina (2011) (48)
- Challenging Regeneration to Transform Medicine (2016) (48)
- Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform (2017) (47)
- The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons. (2014) (46)
- Neurogenesis and neuroadaptation (2007) (45)
- Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells. (2007) (44)
- Targeted synthetic gene delivery vectors. (2000) (44)
- AAV‐mediated gene delivery in Dp71‐null mouse model with compromised barriers (2014) (44)
- Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties (2010) (42)
- Engineering microenvironments to control stem cell fate and function (2008) (41)
- Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities (2016) (40)
- Imaging Light Responses of Foveal Ganglion Cells in the Living Macaque Eye (2014) (40)
- A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes. (2017) (40)
- Computational and experimental analysis of DNA shuffling (2003) (37)
- Bidirectional regulation of mRNA translation in mammalian cells by using PUF domains. (2014) (37)
- Biophysical regulation of stem cell behavior within the niche (2012) (37)
- Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive (2013) (35)
- Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture. (2011) (35)
- The biology and engineering of stem‐cell control (2004) (35)
- hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model (2018) (34)
- Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors (2013) (34)
- Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics (2019) (33)
- Progress and prospects for stem cell engineering. (2011) (32)
- The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. (2015) (32)
- In vivo directed evolution of AAV in the primate retina. (2020) (32)
- Systems biology approaches to understanding stem cell fate choice. (2010) (31)
- Enhanced selective gene delivery to neural stem cells in vivo by an adeno-associated viral variant (2015) (30)
- Chromatin accessibility at the HIV LTR promoter sets a threshold for NF-κB mediated viral gene expression. (2012) (30)
- Light-inducible activation of target mRNA translation in mammalian cells. (2013) (30)
- HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites. (2012) (29)
- The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage (2018) (28)
- High‐Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays (2007) (26)
- Genetic Selection for Context-Dependent Stochastic Phenotypes: Sp1 and TATA Mutations Increase Phenotypic Noise in HIV-1 Gene Expression (2013) (26)
- Multivalent hyaluronic acid bioconjugates improve sFlt-1 activity in vitro. (2016) (25)
- Library selection and directed evolution approaches to engineering targeted viral vectors (2007) (25)
- Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scattering. (2012) (25)
- Microelastic mapping of the rat dentate gyrus (2016) (24)
- Influence of hippocampal niche signals on neural stem cell functions during aging (2017) (24)
- In vivo–directed evolution of adeno-associated virus in the primate retina (2020) (23)
- Enhanced Sialic Acid-Dependent Endocytosis Explains the Increased Efficiency of Infection of Airway Epithelia by a Novel Adeno-Associated Virus (2011) (23)
- Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. (2011) (23)
- Computational Models of HIV-1 Resistance to Gene Therapy Elucidate Therapy Design Principles (2010) (23)
- High-Throughput, Library-Based Selection of a Murine Leukemia Virus Variant To Infect Nondividing Cells (2006) (23)
- In situ stem cell therapy: novel targets, familiar challenges. (2005) (22)
- Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits (2018) (22)
- Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells (2019) (22)
- Gene delivery to the retina using lentiviral vectors. (2006) (22)
- Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach (2020) (22)
- The matrix delivers (1999) (21)
- Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery (2010) (21)
- Novel GP64 envelope variants for improved delivery to human airway epithelial cells (2017) (20)
- Biomaterial Microenvironments to Support the Generation of New Neurons in the Adult Brain (2014) (20)
- High‐throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture (2018) (20)
- Antiviral RNAi: Translating Science Towards Therapeutic Success (2011) (20)
- Colloids as Mobile Substrates for the Implantation and Integration of Differentiated Neurons into the Mammalian Brain (2012) (18)
- Directed Evolution of AAV Mutants for Enhanced Gene Delivery (2004) (18)
- Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells (2020) (18)
- scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution (2021) (18)
- Bringing next-generation therapeutics to the clinic through synthetic biology. (2012) (18)
- Engineering Biomaterials for Synthetic Neural Stem Cell Microenvironments (2008) (18)
- Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies. (2017) (18)
- Advanced targeting strategies for murine retroviral and adeno-associated viral vectors. (2005) (17)
- Targeted diversification in the S. cerevisiae genome with CRISPR-guided DNA polymerase I. (2020) (17)
- Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis (2014) (17)
- Viral packaging and transduction of adult hippocampal neural progenitors. (2010) (17)
- Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing. (2015) (17)
- hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding (2013) (16)
- Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing. (2017) (16)
- Adeno-Associated Virus Vector for Central Nervous System Gene Therapy. (2021) (16)
- In vitro culture and analysis of adult hippocampal neural progenitors. (2010) (15)
- β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells (2020) (15)
- Microarraying the cellular microenvironment (2006) (15)
- Development of quantitative PCR methods to analyse neural progenitor cell culture state (2006) (14)
- Expansion of human pluripotent stem cells (2017) (14)
- Quantitative stem cell imaging with magnetic particle imaging (2013) (14)
- In vivo hypermutation and continuous evolution (2022) (14)
- Dopaminergic Neurons Transplanted Using Cell‐Instructive Biomaterials Alleviate Parkinsonism in Rodents (2018) (14)
- Enhanced preparation of adeno‐associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus (2007) (14)
- Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells. (2016) (13)
- cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming. (2015) (13)
- Challenges in nucleic acid‐lipid films for transfection (2013) (13)
- Transposon-based mutagenesis generates diverse adeno-associated viral libraries with novel gene delivery properties. (2008) (13)
- Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics (2018) (13)
- Gene therapy and gene delivery systems (2005) (12)
- Engineering biomaterials to control the neural differentiation of stem cells (2019) (12)
- Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation (2018) (11)
- Gene Editing to Generate Versatile Human Pluripotent Stem Cell Reporter Lines for Analysis of Differentiation and Lineage Tracing (2019) (11)
- Corrigendum to “Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: A model system to study neurotoxicity in Alzheimer's disease” [Neurobiol. Dis. 62 (2014) 62–72] (2014) (11)
- Microenvironmental Regulation of Stem Cells by Biophysical and Material Cues (2010) (11)
- Isolation of adult hippocampal neural progenitors. (2010) (10)
- Translational repression using BIV Tat peptide-TAR RNA interaction in mammalian cells. (2013) (10)
- Mutual Information Analysis Reveals Coevolving Residues in Tat That Compensate for Two Distinct Functions in HIV-1 Gene Expression* (2012) (10)
- Adeno-associated virus-mediated delivery of CRISPR-Cas9 for genome editing in the central nervous system. (2018) (10)
- High‐throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate (2018) (10)
- Engineered AAV vectors for improved central nervous system gene delivery (2015) (9)
- Proliferation versus Differentiation: Redefining Retinoic Acid’s Role (2018) (9)
- Use of the Green Fluorescent Protein as a Quantitative Reporter of Epidermal Growth Factor Receptor-Mediated Gene Delivery (1997) (9)
- AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems (2019) (8)
- Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. (2018) (8)
- A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line. (2017) (8)
- Directed evolution of adeno-associated virus for enhanced gene delivery to pluripotent and adult neural stem cells (2013) (7)
- eScholarship Title Supplemental Data : Stochastic Gene Expression in a Lentiviral Positive Feedback Loop : HIV-1 Tat Fluctuations Drive Phenotypic Diversity Permalink (2005) (7)
- A global assessment of stem cell engineering. (2014) (7)
- Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy (2020) (6)
- Exploring and Engineering Stem Cells and their Niches. (2007) (6)
- The delivery challenge: fulfilling the promise of therapeutic genome editing (2020) (6)
- Optogenetic tools for cell biological applications. (2017) (6)
- A medium‐throughput analysis of signaling pathways involved in early stages of stem cell reprogramming (2015) (6)
- Machine learning-based library design improves packaging and diversity of adeno-associated virus (AAV) libraries (2021) (6)
- In vivo directed evolution of AAV in the primate retina (2019) (6)
- Mastering their own fates through the matrix (2019) (6)
- One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway. (2020) (5)
- scAAVengr: Single-cell transcriptome-based quantification of engineered AAVs in non-human primate retina (2020) (5)
- Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment (2022) (5)
- Stem cell engineering : principles and practices (2012) (5)
- High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture. (2021) (4)
- Engineering the Surface Properties of Synthetic Gene Delivery Vectors (2002) (4)
- High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates (2020) (4)
- Neurogenesis in adult brain: understanding its mechanism and regulation (2004) (4)
- Genome-wide activation screens to increase adeno-associated virus production (2021) (4)
- hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. (2018) (4)
- Corrigendum to “Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits” [Curr. Opin. Neurobiol. 50 (2018) 163–170] (2018) (4)
- Effects of Molecular Size on Resolution in Charge Detection Mass Spectrometry. (2022) (4)
- Protocol to Fabricate Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics (2020) (3)
- A scalable and tunable thermoreversible polymer for 3D human pluripotent stem cell biomanufacturing (2022) (3)
- 119. Engineering a Self-Inactivating CRISPR System for AAV Vectors (2016) (3)
- Gene Therapy and Gene Delivery Systems as Future Human Therapeutics (2005) (3)
- Designing Tunable Artificial Matrices for Stem Cell Culture (2011) (3)
- Protocols for Adult Stem Cells (2010) (3)
- Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy (2022) (3)
- Novel lung tropic AAV capsids for therapeutic gene delivery. (2020) (3)
- Library selection approaches to engineering enhanced retroviral and lentiviral vectors. (2008) (3)
- Simple, Affordable, and Modular Patterning of Cells using DNA. (2021) (3)
- High ‐ throughput identificationof factorspromotingneuronal differentiation of human neural progenitor cells inmicroscale 3 D cell culture (2019) (3)
- Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell-ECM Interactions. (2021) (3)
- Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates (2021) (2)
- In vivo imaging of ganglion cell physiology in macaque fovea using a calcium indicator (2012) (2)
- Signal dynamics in Sonic hedgehog tissue patterning (2006) (2)
- CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics. (2020) (2)
- Response to “HIV Escape From RNAi Antivirals: Yet Another Houdini Action?” (2012) (2)
- 2.202 – Engineering Viruses For Gene Therapy (2011) (2)
- Developing Photoreceptor Targeted AAV Variant by Directed Evolution (2011) (2)
- Identification and Characterization of a Novel AAV Capsid and Product for the Treatment of Cystic Fibrosis (2021) (2)
- AAV shuffles to the liver: commentary on Lisowski et al. (2014) (2)
- Quantitative analysis of signaling mechanisms controlling adult neural progenitor cell proliferation (2004) (2)
- 5.508 – Scaffold Materials for hES Cell Culture and Differentiation (2011) (2)
- Matrix degradation: Making way for neural stemness. (2017) (2)
- Conjugation of proteins to polymer chains to create multivalent molecules. (2014) (2)
- Apodization Specific Fitting for Improved Resolution, Charge Measurement, and Data Analysis Speed in Charge Detection Mass Spectrometry. (2022) (2)
- Gene Therapy Takes a Cue from HAART: Combinatorial Antiviral Therapeutics Reach the Clinic (2010) (2)
- Characterization of an optogenetic translation activation system (2014) (1)
- Genetic Approaches to Tissue Engineering (2002) (1)
- Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus. (2014) (1)
- Functional characterization of coevolving sites in HIV-1 Tat ! ! 1 ! Mutual Information Analysis Reveals Coevolving Residues in Tat that Compensate for Two Distinct Functions in HIV-1 Gene Expression * (2012) (1)
- Directed evolution identifies novel AAV capsid variants for targeting the canine outer retina following intravitreal delivery (2016) (1)
- Optogenetic Application to Investigating Cell Behavior and Neurological Disease (2022) (1)
- Newborn neuroblasts feel the field in the adult brain (2013) (1)
- Functional Genomics, Genetics, and Bioinformatics (2015) (1)
- Synaptic scale dopamine disruption in Huntington’s Disease model mice imaged with near infrared catecholamine nanosensors (2022) (1)
- Dalkara Therapeutic Outer Retinal Gene Delivery from the Vitreous Directed Evolution of a New Adeno-Associated Virus for − In Vivo (2013) (1)
- Towards A DNA-Directed RNA Interference (ddRNAi) Therapy Delivered Intravitreally Using a Novel AAV Capsid to Treat Choroidal Neovascularization (CNV) (2017) (1)
- Microarraying for mechanosensivitity. (2010) (1)
- Emerging Engineering Strategies for Studying the Stem Cell Niche (2015) (1)
- Epidermal growth factor receptor-mediated gene delivery : a model system for engineering selective gene therapy approaches (1998) (1)
- 5.8 Scaffold Materials for Human Embryonic Stem Cell Culture and Differentiation (2017) (1)
- EPAC Signaling Functionally Replace OCT 4 During Induced Pluripotent Stem Cell Reprogramming (1)
- Viral infection: A key host receptor for AAV (2016) (1)
- 725. Engineering Enhanced Retroviral Vectors by Random Insertion of Functional Peptides (2004) (1)
- 20. Directed Evolution of AAV2 Yields Novel Capsid Variants (2004) (1)
- Age‐associated Increase in Bmp Signaling In‐ Hibits Hippocampal Neurogenesis * Key Words. Adult Stem Cells @bullet Aging @bullet Neural Stem Cell @bullet Proliferation @bullet Neu‐ Rogenesis @bullet Stem Cell‐microenvironment Interactions @bullet Bmp Signaling (0)
- Spatiomechanical Modulation of EphB 4-Ephrin-B 2 Signaling in Neural Stem Cell Differentiation (2018) (0)
- 261. Directed Evolution of an Antibody-Evading Cardiac Tropic AAV Vector (2015) (0)
- 4.33 Engineering Viruses For Gene Therapy (2017) (0)
- Genetic Approaches to Tissue Repair (2002) (0)
- Spatial Organization of EphA2 and its Effects on Internalization and Signaling in Living Cells (2012) (0)
- 125. Purging Latent HIV Infection by CRISPR-Mediated Viral Reactivation (2016) (0)
- Characterizing International Stem Cell Research Niches (2014) (0)
- Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities (2014) (0)
- Characterization of CRB1 gene therapy in a retinal degeneration mouse model (2015) (0)
- Directed Evolution of New Adeno-Associated Viral Vectors for Gene Therapy (2015) (0)
- Optogenetic Instruction of Cell Fate by Temporal Patterning of Mechanobiological Signals (2022) (0)
- Novel AAV Variants Show Superior Gene Delivery in Human Retinal Cell Models (2017) (0)
- Lentiviral Vector (HIV-1) Mediated Expression of Sonic Hedgehog in the Retina of P23H Transgenic Rats to Decrease Degeneration and Death of Photoreceptor Cells (2003) (0)
- 3D Microenvironment-Specific Mechanosensing Regulates Neural Stem Cell Lineage Commitment (2021) (0)
- 547. Antiviral RNA Interference Strategies That Resist HIV Escape (2004) (0)
- The role of sonic hedgehog in adult neural progenitor cell proliferation in vitro and in vivo (2002) (0)
- Faculty Opinions recommendation of Environmental Elasticity Regulates Cell-type Specific RHOA Signaling and Neuritogenesis of Human Neurons. (2020) (0)
- Exploring the Spatio-Mechanosensitivity of Eph Receptor in Stem Cells (2014) (0)
- Breaking Down Barriers to AAV Mediated Retinal Transduction Through Intravitreal Injections (2009) (0)
- 617. Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery (2016) (0)
- Retinoschisin Gene Therapy in Photoreceptors, Muller Glia, or All Retinal Cells in the Mouse Model of X-Linked Retinoschisis (2014) (0)
- In vivo optical recording of the light response of primate ganglion cells (2013) (0)
- ShH10, A Novel Müller Glia Cell-specific AAV Vector, Expressing GDNF Promotes Retinal Ganglion Cell Survival Following Neuronal Injury In Thy1-YFP Mice (2012) (0)
- 1085. Directed Evolution of AAV2 Leads to Improved Viral Function (2005) (0)
- Influence of hippocampal niche signals on neural stem cell functions during aging (2017) (0)
- Tissue Distribution and Receptor Affinities of Aav in the Retina (2008) (0)
- The ongoing evolution and translational potential of novel AAV vectors for human gene therapy (2019) (0)
- 1002. Therapeutic Design Principles for Achieving Long-Term Suppression of HIV-1 with RNA Interference (2005) (0)
- Physical and Engineering Principles in Stem Cell Research (2014) (0)
- CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window (2018) (0)
- Optical Recording of the Light Response of Ganglion Cells in the Living Eye (2013) (0)
- Neuroprotective effect of AAV-mediated cell-specific expression of GDNF in Müller glial cells versus retinal ganglion cells in a murine model of glaucoma (2015) (0)
- Imaging light responses of ganglion cells in the living eye. (2014) (0)
- 401. Engineering Retroviral Vectors for Stem Cell Therapies-Overcoming the Effect of Gene Silencing (2004) (0)
- Faculty Opinions recommendation of Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements. (2018) (0)
- Faculty Opinions recommendation of Anillin promotes cell contractility by cyclic resetting of rhoa residence kinetics. (2020) (0)
- Directed evolution of novel adeno-associated viral vectors for gene therapy (2014) (0)
- conditional gene modificatiol (2016) (0)
- Editorial overview: Tissue, cell and pathway engineering. (2018) (0)
- A comprehensive stochastic computational model of HIV infection from DNA integration to viral burst (2017) (0)
- THERMOREVERSIBLE POLYMERS ANDMETHODS OF USE THEREOF (2018) (0)
- Design of a translational repression based RNA switch in mammalian cells (2014) (0)
- Evaluation of CRB1 gene delivery in the rd8 mouse (2016) (0)
- Title: Inhibition of Pathogenic Angiogenesis in Diabetic Retinopathy with a Hyaluronic Acid-based Multivalent VEGF Antagonist Authors: (2013) (0)
- 488. Engineering Enhanced Retroviral Vectors through the Insertion of a His6 Tag into VSV-G (2005) (0)
- Figure 1, Schematic overview view of niche components. (2008) (0)
- Resource Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3 D Culture System (2017) (0)
- Engineering Biomaterials to Direct Stem Cell Fate by Anthony Baer Conway A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Chemical Engineering in the Graduate Division (2013) (0)
- Directed evolution of new viruses for therapeutic gene delivery (2014) (0)
- 120. Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9 (2016) (0)
- Faculty Opinions recommendation of CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease. (2019) (0)
- Genetic approaches to tissue engineering: breakout session summary. (2002) (0)
- Dicer Loss Leads to Müller Cell Gliosis in the Mouse Retina (2013) (0)
- Dalkara 1..11 (2013) (0)
- Biophysical regulation of stem cell behavior within the niche (2012) (0)
- Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and Differentiation (2012) (0)
- In vivo magnetic nanoparticle cytometer for stem cells in small animals (2013) (0)
- Mechanotransductive Engineering of Neural Stem Cell Behavior (2010) (0)
- The Young Innovators of Cellular and Molecular Bioengineering (2014) (0)
- In vivo Targeting of Müller Cells in the Rodent Retina Using Novel Lentiviral Vectors (2005) (0)
- The Coming of Age of Topical Gene Therapy for Dystrophic Epidermolysis Bullosa. (2022) (0)
- Figure 3, Sequential soluble factors specify differentiation programs. (2008) (0)
- 507. Engineering a Novel AAV Variant for Purification Via Immobilized Metal Affinity Chromatography (2006) (0)
- Cheaper and less variable expansion (2018) (0)
- 126. Retinoschisin Gene Therapy in Photoreceptors, Muller Glia, or All Retinal Cells in the Mouse Model of X-Linked Retinoschisis (2016) (0)
- AAV-mediated gene therapy in Dystrophin-Dp71 deficient mouse leads to blood-retinal barrier permeability restoration (2014) (0)
- Figure 2, Tethered growth factor ligands allow sustained signaling without receptor mediated internalization. (2008) (0)
- In vivo analysis of engrafted adult hippocampal neural progenitors. (2010) (0)
- Faculty Opinions recommendation of Generation and post-injury integration of human spinal cord neural stem cells. (2018) (0)
- 519. Selective Inactivation of Helper Adenovirus with High Hydrostatic Pressure for AAV-2 Vector Production (2005) (0)
- 736. Engineering Enhanced Retroviral and Lentiviral Vectors through the Selection of Peptide Insertion Libraries (2006) (0)
- Ross River Virus Pseudotyped HIV–1 Efficiently and Stably Transduces Rodent Müller Cells In Vitro (2004) (0)
- A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation (2022) (0)
- Cheaper and less variable expansion (2018) (0)
- Gene targeting within stem cells using directly evolved adeno-associated viral vectors (2009) (0)
- Scalable production of dopaminergic neuron progenitors for treating parkinson's disease (2013) (0)
- Engineering the Interface Between Inorganic Materials and Cells (2014) (0)
- The Young Innovators of Cellular and Molecular Bioengineering (2014) (0)
- A Single-Molecule View of Genome Editing Proteins : Biophysical Mechanisms for TALEs and CRISPR / Cas 9 (2017) (0)
- A Conversation with John McKetta (2020) (0)
- Editorial Functional Genomics, Genetics, and Bioinformatics (2014) (0)
- Computationally Assisted Design of High Signal-to-Noise Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes (2020) (0)
- Author response: scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution (2021) (0)
- Faculty Opinions recommendation of Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. (2018) (0)
- Cover Image, Volume 116, Number 1, January 2019 (2018) (0)
- Faculty Opinions recommendation of Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. (2018) (0)
- Removing the Requirement for Subretinal Injection: Intravitreal Delivery of Engineered AAV-GDNF Can Provide Sustained Photoreceptor Protection Without Retinal Detachement (2010) (0)
- Shh10, A Novel müLler Glia Cell-specific Aav Vector, Expressing Gdnf Is Neuroprotective In Murine Model Of Microbead-induced Glaucoma (2012) (0)
- Response to "HIV Escape From RNAi Antivirals: Yet Another Houdini Action?" (2012) (0)
- Purification of Aav gene therapy vectors by selectively inactivating helper adenovirus using high hydrostatic pressure (2005) (0)
- Temporal Tropism for Recombinant Lentiviral-GFP Transduction of Photoreceptors in C57BL/6 Mice (2003) (0)
- Molecular Engineering of Adeno-Associated Virus Yields a Novel Variant With Efficient Intravitreal Transduction of Müller Cells (2009) (0)
- Molecular Engineering of Stem Cell and Gene Therapies (2009) (0)
- Chapter 76 – Designing Tunable Artificial Matrices for Stem Cell Culture (2013) (0)
- Computational design of RNA interference gene therapy strategies to treat HIV-1 infections and block viral escape (2005) (0)
- Mechanisms of antigen presentation in recombinant adeno-associated virus (rAAV) vector mediated vaccination and gene therapy (130.36) (2010) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With David. V. Schaffer?
David. V. Schaffer is affiliated with the following schools:
