Debashis Ghosh
#185,513
Most Influential Person Now
Debashis Ghosh's AcademicInfluence.com Rankings
Debashis Ghoshbiology Degrees
Biology
#15595
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#19613
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Molecular Biology
#2703
World Rank
#2744
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Biochemistry
#2741
World Rank
#2929
Historical Rank
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Chemistry Biology
Debashis Ghosh's Degrees
- PhD Biochemistry Stanford University
- Masters Chemistry Stanford University
- Bachelors Chemistry Stanford University
Why Is Debashis Ghosh Influential?
(Suggest an Edit or Addition)Debashis Ghosh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Short-chain dehydrogenases/reductases (SDR). (1995) (1211)
- Structural basis for androgen specificity and oestrogen synthesis in human aromatase (2009) (466)
- Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution. (1995) (240)
- Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family. (1991) (197)
- Structure of the insecticidal bacterial δ-endotoxin Cry3Bb1 of Bacillus thuringiensis (2001) (183)
- The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases (1994) (179)
- Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association* (2003) (157)
- Human Peroxiredoxin 1 and 2 Are Not Duplicate Proteins (2007) (144)
- Novel aromatase inhibitors by structure-guided design. (2012) (143)
- Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+. (1999) (105)
- Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. (1995) (100)
- Human sulfatases: A structural perspective to catalysis (2007) (95)
- X-ray structure of human aromatase reveals an androgen-specific active site (2010) (84)
- Porcine Carbonyl Reductase (2001) (82)
- Steroid dehydrogenase structures, mechanism of action, and disease. (2000) (78)
- Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis. (1997) (74)
- Origin of Substrate Specificity of Human and Rat 17β-Hydroxysteroid Dehydrogenase Type 1, Using Chimeric Enzymes and Site-Directed Substitutions. (1997) (67)
- Structural basis for the functional roles of critical residues in human cytochrome p450 aromatase. (2013) (67)
- Iron-sulfur clusters in Azotobacter ferredoxin at 2.5 A resolution. (1980) (64)
- Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective. (2016) (62)
- FUNCTIONAL SIGNIFICANCE OF A NATURAL ALLELIC VARIANT OF HUMAN CARBONYL REDUCTASE 3 (CBR3) (2005) (61)
- Multiple Conformations of Catalytic Serine and Histidine in Acetylxylan Esterase at 0.90 Å* (2001) (60)
- Structure of a 7Fe ferredoxin from Azotobacter vinelandii. (1981) (60)
- Purification, characterization and crystallization of human placental estrone/dehydroepiandrosterone sulfatase, a membrane-bound enzyme of the endoplasmic reticulum (2001) (59)
- A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity (2007) (58)
- Structure and function of 17β-hydroxysteroid dehydrogenase type 1 and type 2 (2001) (56)
- Crystallization and preliminary X-ray diffraction analysis of the complex of human placental 17 beta-hydroxysteroid dehydrogenase with NADP+. (1993) (55)
- Mechanism of inhibition of estrogen biosynthesis by azole fungicides. (2014) (54)
- Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase. (1993) (54)
- Structural perturbation of α-crystallin and its chaperone-like activity (1998) (53)
- Mechanism of inhibition of 3α,20β-hydroxysteroid dehydrogenaseby a licorice-derived steroidal inhibitor (1994) (49)
- Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17β-Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum. (1999) (49)
- Determination of a protein structure by iodination: the structure of iodinated acetylxylan esterase. (1999) (48)
- Motion and Flexibility in Human Cytochrome P450 Aromatase (2012) (47)
- Three‐dimensional model of NAD+‐dependent 15‐hydroxyprostaglandin dehydrogenase and relationships to the NADP+‐dependent enzyme (carbonyl reductase) (1993) (42)
- Evidence for an Elevated Aspartate pKa in the Active Site of Human Aromatase* (2014) (41)
- Monomeric and dimeric forms of cholesterol esterase from Candida cylindracea (1994) (40)
- The fascinating complexities of steroid-binding enzymes. (1996) (38)
- Molecular mechanisms of estrogen recognition and 17-keto reduction by human 17beta-hydroxysteroid dehydrogenase 1. (2001) (37)
- Subcellular localization, substrate specificity and crystallization of duodenase, a potential activator of enteropeptidase. (1997) (36)
- Structure and function of steroid dehydrogenases involved in hypertension, fertility, and cancer (1997) (34)
- Three-dimensional structures of sulfatases. (2005) (32)
- Testosterone complex and non-steroidal ligands of human aromatase (2018) (32)
- Acetyl xylan esterase II from Penicillium purpurogenum is similar to an esterase from Trichoderma reesei but lacks a cellulose binding domain (1998) (30)
- Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. (2005) (30)
- Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore. (1999) (28)
- The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases. (1994) (27)
- Inhibition of Streptomyces hydrogenans 3α,20β-hydroxysteroid dehydrogenase by licorice-derived compounds and crystallization of an enzyme-cofactor-inhibitor complex (1992) (24)
- Module structure of interphotoreceptor retinoid-binding protein (IRBP) may provide bases for its complex role in the visual cycle – structure/function study of Xenopus IRBP (2007) (23)
- Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype* (2016) (22)
- Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase. (2004) (20)
- Convenient method for the functionalization of the 4- and 6-positions of the androgen skeleton. (2012) (18)
- Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase. (1996) (17)
- Structural Basis of Antigen Mimicry in a Clinically Relevant Melanoma Antigen System* (2005) (17)
- Higher order organization of human placental aromatase (2011) (17)
- Suppression of human cytochrome P450 aromatase activity by monoclonal and recombinant antibody fragments and identification of a stable antigenic complex (2004) (15)
- Origin of substrate specificity of human and rat 17beta-hydroxysteroid dehydrogenase type 1, using chimeric enzymes and site-directed substitutions. (1997) (15)
- Crystallization and preliminary diffraction analysis of cholesterol esterase from Candida cylindracea (1991) (14)
- Estrogen Metabolism as a Regulator of Estrogen Action in the Mammary Gland (2000) (13)
- Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum. (1999) (11)
- Phosphorylation of human placental aromatase CYP19A1. (2019) (11)
- Structural perturbation of alpha-crystallin and its chaperone-like activity. (1998) (11)
- Molecular Mechanism of Inhibition of Steroid Dehydrogenases by Licorice‐Derived Steroid Analogs in Modulation of Steroid Receptor Function a (1995) (10)
- The Structure of Pea Lectin-D-Glucopyranose Complex at a 1.9 A Resolution (1997) (10)
- Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor. (1994) (8)
- Three-dimensional structures of steroids and their protein targets (1996) (8)
- Structure and mechanism of action and inhibition of steroid dehydrogenase enzymes involved in hypertension. (1998) (7)
- Crystallization and preliminary x-ray diffraction studies of a mammalian steroid dehydrogenase (1993) (6)
- Structure of an activity suppressing Fab fragment to cytochrome P450 aromatase: insights into the antibody-antigen interactions. (1999) (6)
- Presence of Specific Receptor Binding Sites for Inhibin in Rat Spermatids (2009) (6)
- Fructose‐1,6‐bisphosphatase. Primary structure of the rabbit liver enzyme. ‘Intermediate’ variability of an oligomeric protein (1996) (6)
- Characterization of crystals of Penicillium purpurogenum acetyl xylan esterase from high‐resolution X‐ray diffraction (1996) (6)
- Crystals of active tetramers of 3 alpha, 20 beta-hydroxysteroid dehydrogenase. (1986) (5)
- Purification of the full-length Xenopus interphotoreceptor retinoid binding protein and growth of diffraction-quality crystals (2007) (5)
- 3alpha/beta,20beta-hydroxysteroid dehydrogenase (porcine testicular carbonyl reductase) also has a cysteine residue that is involved in binding of cofactor NADPH. (2004) (4)
- 3α/β,20β-Hydroxysteroid dehydrogenase (porcine testicular carbonyl reductase) also has a cysteine residue that is involved in binding of cofactor NADPH (2004) (4)
- Steroid Molecular Structure, Protein Interaction and Biological Function (1994) (3)
- SIGNIFICANCE OF A NATURAL ALLELIC VARIANT OF HUMAN CARBONYL REDUCTASE 3 ( CBR 3 ) (2005) (2)
- Structure, Function and Inhibition of Aromatase (2015) (2)
- Crystallization of prostatic binding protein. (1988) (2)
- A pH-Dependent Structural Rearrangement of the HumanAromatase Active Site: Implications in Catalysis (2010) (2)
- Structure of Ustilago maydis Killer Toxin KP6 α-Subunit (1999) (1)
- Ligand-binding interactions and quaternary association in human aromatase (2011) (1)
- USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT (1999) (1)
- Structure, Mechanism of Action and Inhibition of Dehydrogenase Enzymes (1998) (1)
- Inhibition of Streptomyces hydrogenans 3 alpha,20 beta-hydroxysteroid dehydrogenase by licorice-derived compounds and crystallization of an enzyme-cofactor-inhibitor complex. (1992) (1)
- Crystal structure of human placental aromatase complexed with breast cancer drug exemestane (2012) (1)
- Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione (2008) (1)
- Structure of Human Placental Estrone/DHEA Sulfatase (2003) (1)
- An Innovative Gene Identification and Classification Method by Bidirectional String Matching Algorithm and SVM Classifier (2014) (0)
- Cytochrome P450lin(P450111): crystal unit cell, tertiary structure-function model (1992) (0)
- X-ray crystal structure analysis of 3α,20β-hydroxysteroid dehydrogenase fromStreptomyces hydrogenans: a progress report (1987) (0)
- CRYSTAL STRUCTURE OF RABBIT LIVER FRUCTOSE-1,6-BISPHOSPHATASE AT 2.3 ANGSTROM RESOLUTION (1998) (0)
- Equilin. (2020) (0)
- Structure of a 7 Fe Ferredoxin from Azotobacter uineZandii * (2001) (0)
- Structure of Recombinant Human Cytochrome P450 Aromatase (2013) (0)
- Structural basis of tumor antigen mimicry by a mimotope isolated from a phage display peptide library (2006) (0)
- STRUCTURE OF AN ACTIVITY SUPPRESSING FAB FRAGMENT TO CYTOCHROME P450 AROMATASE (2000) (0)
- HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #3 (2017) (0)
- Effect of pH on the conformation and activity of human aromatase (2010) (0)
- ACETYLXYLAN ESTERASE AT 0.90 ANGSTROM RESOLUTION (2001) (0)
- Structure of human placental steroid sulfatase at 2.0 angstrom resolution: Catalysis, quaternary association, and a secondary ligand site (2022) (0)
- HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #4 (2017) (0)
- TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+ (1999) (0)
- Human placental aromatase cytochrome P450 (CYP19A1) refined at 2.75 angstrom (2012) (0)
- An An An Innovative Innovative Innovative Innovative Gene Identification Gene Identification Gene Identification Gene Identification and Classification Method by and Classification Method by and Classification Method by and Classification Method by Bidirectional String Matching Algorithm Bidirection (2014) (0)
- Tyr-Lys based catalysis: the foundation for structural homology among short-chain dehydrogenase/reductases (1996) (0)
- Structure of human placental aromatase complexed with designed inhibitor HDDG046 (compound 5) (2012) (0)
- Sequence, conformation, and function of peptides, retro peptides and sense and antisense gene products (1999) (0)
- HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) AT 2.75 ANGSTROM WITH BOUND POLYETHYLENE GLYCOL (2017) (0)
- Structure of human placental aromatase complexed with designed inhibitor HDDG029 (compound 4) (2012) (0)
- Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression (2018) (0)
- Crystal structures of steroid dehydrogenase enzymes (1993) (0)
- IODINATED COMPLEX OF ACETYL XYLAN ESTERASE AT 1.80 ANGSTROMS (1999) (0)
- HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #2 (2017) (0)
- HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) COMPLEXED WITH TESTOSTERONE (2017) (0)
- Three-dimensional structure of holo 3 a , 20 j 3-hydroxysteroid dehydrogenase : A member of a short-chain dehydrogenase family ( x-ray crystaflography / steroid-metabolizing enzyme / dinucleotide-linked oxldoreductase / sterold-protein interaction / sequence and folding homologies ) (0)
- ACETYLXYLAN ESTERASE FROM P. PURPUROGENUM REFINED AT 1.10 ANGSTROMS (1999) (0)
- EFFECT OF pH ON AROMATASE STRUCTURE AND ACTIVITY: CRUCIAL ROLE OF ASPARTIC ACID 309. (2011) (0)
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