Debbie Hay
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New Zealand molecular pharmacologist
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Debbie Hay's Degrees
- Bachelors Pharmacology University of Auckland
- Masters Molecular Pharmacology University of New Zealand
Why Is Debbie Hay Influential?
(Suggest an Edit or Addition)According to Wikipedia, Deborah Lucy Hay is a New Zealand academic. In 2022, she was elected a Fellow of the Royal Society Te Apārangi. Academic career After an undergraduate in pharmacology at the University of Sheffield, Hay did a PhD in molecular pharmacology entitled 'Investigation of the calcitonin receptor-like receptor and receptor activity modifying proteins' at Imperial College London. Hay moved to the University of Auckland, where she rose to full professor. She is now a full professor at the University of Otago and is a Fellow of the British Pharmacological Society.
Debbie Hay's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Oxyntomodulin inhibits food intake in the rat. (2001) (280)
- GPCR modulation by RAMPs. (2006) (248)
- Amylin: Pharmacology, Physiology, and Clinical Potential (2015) (244)
- Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25 (2018) (225)
- THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors (2021) (212)
- Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes (2005) (185)
- Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor (2018) (169)
- Regulation of signal transduction by calcitonin gene-related peptide receptors. (2010) (140)
- A second trigeminal CGRP receptor: function and expression of the AMY1 receptor (2015) (138)
- The pharmacology of Adrenomedullin 2/Intermedin (2012) (132)
- Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles. (2016) (132)
- CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22–52, CGRP8–37 and BIBN4096BS (2003) (131)
- Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor (2015) (100)
- Pharmacology of the human CGRP1 receptor in Cos 7 cells (2006) (89)
- International Union of Pharmacology. LXIX. Status of the Calcitonin Gene-Related Peptide Subtype 2 Receptor (2008) (89)
- CGRP and its receptors (2017) (88)
- Measurement of Phosphorylated Extracellular Signal–Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology (2009) (83)
- Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development. (2011) (82)
- The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors (2004) (82)
- Determinants of 1-Piperidinecarboxamide, N-[2-[[5-Amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors—The Role of Rec (2006) (81)
- Amylin receptors: molecular composition and pharmacology. (2004) (79)
- Differential activation of G‐proteins by μ‐opioid receptor agonists (2006) (76)
- CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors? (2013) (76)
- Calcitonin and calcitonin receptor‐like receptors: common themes with family B GPCRs? (2012) (71)
- Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity. (2010) (70)
- The receptor activity modifying protein family of G protein coupled receptor accessory proteins. (2004) (70)
- Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines (2002) (69)
- Identification of N-Terminal Receptor Activity-Modifying Protein Residues Important for Calcitonin Gene-Related Peptide, Adrenomedullin, and Amylin Receptor Function (2008) (68)
- Migraine: disease characterisation, biomarkers, and precision medicine (2021) (64)
- Amylin structure–function relationships and receptor pharmacology: implications for amylin mimetic drug development (2016) (60)
- Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs. (2006) (60)
- Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. (2020) (59)
- A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. (2005) (59)
- Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges. (2010) (58)
- CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured (2018) (58)
- Modulating receptor function through RAMPs: can they represent drug targets in themselves? (2009) (56)
- The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development. (2012) (53)
- Adrenomedullin receptors: molecular identity and function (2001) (52)
- Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors. (2014) (52)
- Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies (2013) (52)
- Interaction of calcitonin-gene-related peptide with its receptors. (2001) (52)
- Structure–activity relationships for α‐calcitonin gene‐related peptide (2013) (52)
- A comparison of the actions of BIBN4096BS and CGRP8–37 on CGRP and adrenomedullin receptors expressed on SK‐N‐MC, L6, Col 29 and Rat 2 cells (2002) (51)
- Molecular studies of CGRP and the CGRP family of peptides in the central nervous system (2019) (49)
- Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14. (2015) (46)
- Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin. (2004) (45)
- An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology (2016) (42)
- Receptor activity‐modifying protein‐dependent impairment of calcitonin receptor splice variant Δ(1–47)hCT(a) function (2013) (42)
- Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin. (2018) (40)
- A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor (2010) (40)
- Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3 (2009) (40)
- Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. (2010) (39)
- Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties* (2016) (38)
- Knockouts and transgenics confirm the importance of adrenomedullin in the vasculature. (2001) (37)
- PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells (2014) (37)
- Structure–function relationships of the N‐terminus of receptor activity‐modifying proteins (2010) (36)
- Identification of key residues involved in adrenomedullin binding to the AM1 receptor (2013) (35)
- Structure and dynamics of the CGRP receptor in apo and peptide-bound forms (2021) (35)
- Calcitonin and amylin receptor peptide interaction mechanisms. INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS. (2016) (34)
- Complexing Receptor Pharmacology (2006) (34)
- Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism. (2014) (32)
- Probing the Mechanism of Receptor Activity–Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists (2018) (32)
- Structure–activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation (2013) (32)
- Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology (2014) (32)
- Calcitonin and Amylin Receptor Peptide Interaction Mechanisms (2016) (32)
- The Molecular Control of Calcitonin Receptor Signaling. (2019) (31)
- New Insights into the Regulation of CGRP-Family Receptors. (2019) (31)
- Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. (2016) (31)
- Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors. (2020) (30)
- The pharmacology of CGRP-responsive receptors in cultured and transfected cells (2004) (30)
- Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization. (2008) (30)
- Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist. (2018) (29)
- Agonist‐dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor (2007) (29)
- Amylin Analog Pramlintide Induces Migraine‐like Attacks in Patients (2021) (28)
- The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach (2013) (28)
- Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs (2017) (27)
- Desensitisation of adrenomedullin and CGRP receptors (2003) (27)
- Structure-function analysis of RAMP1 by alanine mutagenesis. (2009) (26)
- Effects of Melanocortin Receptor Ligands on Thyrotropin‐Releasing Hormone Release: Evidence for the Differential Roles of Melanocortin 3 and 4 Receptors (2002) (26)
- Amylin (2017) (24)
- Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors (2011) (23)
- Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy (2018) (23)
- Mapping the calcitonin receptor in human brain stem. (2016) (23)
- A Single Pseudoproline and Microwave Solid Phase Peptide Synthesis Facilitates an Efficient Synthesis of Human Amylin 1–37 (2013) (23)
- Adrenomedullin: receptor and signal transduction. (2002) (23)
- Antagonism of CGRP Signaling by Rimegepant at Two Receptors (2020) (22)
- Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors. (2020) (22)
- Characterization of the structure of RAMP1 by mutagenesis and molecular modeling. (2006) (20)
- Calcitonin gene-related peptide, adrenomedullin and flushing. (2009) (20)
- Secretin family (Class B) G protein‐coupled receptors – from molecular to clinical perspectives (2012) (19)
- Effect of Adrenomedullin on Migraine-Like Attacks in Patients With Migraine (2021) (18)
- N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity. (2017) (18)
- RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors. (2020) (18)
- Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex. (2018) (17)
- The third extracellular loop of the human calcitonin receptor‐like receptor is crucial for the activation of adrenomedullin signalling (2012) (17)
- RAMPs and CGRP receptors. (2012) (16)
- CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists? (2021) (16)
- Immunohistochemical detection of the calcitonin receptor-like receptor protein in the microvasculature of rat endothelium. (2003) (15)
- A structural basis for amylin receptor phenotype (2022) (15)
- Amyloidogenicity, Cytotoxicity, and Receptor Activity of Bovine Amylin: Implications for Xenobiotic Transplantation and the Design of Nontoxic Amylin Variants. (2018) (14)
- Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors. (2020) (13)
- Beyond CGRP: The calcitonin peptide family as targets for migraine and pain (2021) (12)
- Functional characterization of two human receptor activity-modifying protein 3 variants (2010) (12)
- Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared with human receptors (2021) (11)
- RAMPs as drug targets. (2012) (11)
- α-Calcitonin gene related peptide (α-CGRP) mediated lipid mobilization in 3T3-L1 adipocytes (2014) (11)
- Receptor activity modifying proteins and their potential as drug targets. (2010) (11)
- Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice (2020) (11)
- An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology (2016) (11)
- Receptor Activity Modifying Proteins Have Limited Effects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-Like Receptor Stalk. (2018) (10)
- CGRP Receptor Biology: Is There More Than One Receptor? (2018) (10)
- Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats (2015) (10)
- Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor. (2019) (9)
- Functions of third extracellular loop and helix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking. (2013) (9)
- The preclinical pharmacology of BIBN4096BS, a CGRP antagonist. (2006) (9)
- Reply to comment on: A second trigeminal CGRP receptor: function and expression of the AMY1 receptor (2016) (9)
- Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies. (2021) (8)
- Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry. (2016) (8)
- CGRP receptor heterogeneity: a role for receptor component protein? (2003) (8)
- Structure-function analysis of RAMP1-RAMP3 chimeras. (2010) (8)
- A potent fluorescent calcitonin gene‐related peptide analogue enables visualization of receptor internalization (2019) (7)
- A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene‐related peptide and beyond (2022) (7)
- Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist (2018) (7)
- Calcitonin Gene-Related Peptide Receptor* (2007) (7)
- Pharmacological characterization and investigation of N-terminal loop amino acids of adrenomedullin 2 that are important for receptor activation. (2019) (6)
- CGRP receptor antagonists: design and screening (2009) (6)
- Analysis of Amylin Consensus Sequences Suggests that Human Amylin is Not Optimized to Minimize Amyloid Formation and Provides Clues to Factors that Modulate Amyloidogenicity. (2020) (6)
- Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors (2020) (6)
- Characterisation of agonist signalling profiles and agonist‐dependent antagonism at PACAP‐responsive receptors: Implications for drug discovery (2021) (6)
- dibromo-4-hydroxyphenyl ) methyl ]-2-oxoethyl ]-4-( 1 , 4-dihydro-2-oxo-3 ( 2 H )-quinazolinyl ) ( BIBN 4096 BS ) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors — The Role of Receptor Activity Modifying Protein 1 (2006) (6)
- An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology (2016) (6)
- Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor (2021) (6)
- The Calcitonin Gene-related Peptide Family Form , Function and Future Perspectives (2010) (6)
- The calcitonin gene-related peptide family (2010) (6)
- Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems (2001) (5)
- Calcitonin receptor antibody validation and expression in the rodent brain (2022) (4)
- Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo (2022) (4)
- The role of ECL 2 in CGRP receptor activation : a combined modelling and experimental approach (2013) (4)
- The role of glutamic acid 73 in adrenomedullin interactions with rodent AM2 receptors (2012) (4)
- Calcitonin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (4)
- CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons (2022) (4)
- Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins (2022) (3)
- Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. (2018) (3)
- Synthesis of isotopically labelled αCGRP8-37 and its lipidated analogue. (2020) (2)
- Differential internalisation of the CGRP and AMY1 receptor (2020) (1)
- Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments (2022) (1)
- Novel Fluorescently Labeled PACAP and VIP Highlight Differences between Peptide Internalization and Receptor Pharmacology. (2022) (1)
- Vasopressin-oxytocin–type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians (2022) (1)
- Obesity pharmacotherapy: incretin action in the central nervous system. (2022) (1)
- PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies (2022) (1)
- Corrigendum to “The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development” [Drug Discov. Today 17 (17–18) (2012) 1006–1014] (2013) (1)
- A comparison of plasma BIO-LH levels with RIA-LH and IRMA-LH in spontaneous menstrual cycles and in women receiving LHRH agonist treatment for IVF (1988) (1)
- Atogepant (Qulipta) for migraine prevention. (2021) (1)
- Measurement of cAMP in an Undergraduate Teaching Laboratory, Using ALPHAscreen Technology (2012) (1)
- Is calcitonin gene-related peptide a reliable biochemical marker of migraine? (2022) (1)
- CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond. (2022) (1)
- Conclusions and Future Perspectives (2010) (0)
- CT, CGRP, Amylin, and Adrenomedullins (2009) (0)
- Equilibrated structures for the MD simulations (2017) (0)
- Class B GPCR: Receptors and RAMPs (2017) (0)
- Calcitonin Family Receptors (2020) (0)
- Calcitonin receptors in GtoPdb v.2021.2 (2021) (0)
- Endocrine-Related Cancer ( 2011 ) 18 C 1 – C 14 Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers : opportunities and challenges (2010) (0)
- Adrenomedullin receptors in Rat-2 fibroblasts show adrenomedullin mediated desensitisation (2000) (0)
- From barnyard to bedside: using interspecies variants to inform the rational design of novel analogs of islet amyloid polypeptide (2022) (0)
- CGRP family of peptides : IUPHAR Review : ” X ” Running title : Pharmacology of the calcitonin / CGRP family (2017) (0)
- Pharmacology and desensitisation of the human ramp3 and rat crlr combination (2002) (0)
- NOVEL LIPIDATED CGRP PEPTIDE ANTAGONISTS FOR THE TREATMENT OF MIGRAINE AND PAIN (2018) (0)
- Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin (2023) (0)
- Signalling and agonist-selective antagonism at corticotropin-releasing factor receptors (2018) (0)
- Calcitonin Gene-Related Peptide and Adrenomedullin Receptors (2013) (0)
- Pharmacology and Desensitisation of the Human RAMP3 and Rat Calcitonin Receptor-Like Receptor Combination (2001) (0)
- Adsorption von Aminosäuren an Hydroxyapatit (1979) (0)
- Extracellular loops 2 and 3 of the calcitonin G protein-coupled receptor selectively modify agonist binding and efficacy (2017) (0)
- Novel Genetic Variant of a Class B G Protein-Coupled Receptor Reveals a Role for Adrenomedullin in Human Fertility. (2018) (0)
- The Effect of Glycosylation on the Potency of Pramlintide, An Anti-Diabetic Drug (2013) (0)
- A Tale of Two Peptides: Identifying Targets for Migraine (2021) (0)
- Atogepant (Qulipta®) for migraine prevention. (2022) (0)
- Structure-based design of small molecule modulators of the adrenomedullin 1 receptor (2015) (0)
- Characterization of CGRP Receptor Binding (2004) (0)
- A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex (2019) (0)
- Photoa ffi nity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor / Receptor Activity-Modifying Protein 1 ( CLR / RAMP 1 ) Complex (2018) (0)
- Pharmacological Characterisation of PACAP‐responsive Receptors Reveals Signalling Bias and Probe‐dependent Antagonism (2020) (0)
- Advisory Board and Contents (2020) (0)
- Calcitonin-Type Receptors (2008) (0)
- Lessons from the Type II Family of G-Protein-Coupled Receptors (2002) (0)
- Chapter 14:Modulating Receptor Function through RAMPs (2011) (0)
- Data underpinning article "Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex" (2018) (0)
- Recent progress in unraveling the complexities of receptor biology: towards new therapeutics (2012) (0)
- Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale (2022) (0)
- A Single Pseudoproline and Microwave Solid Phase Peptide Synthesis Facilitates an Efficient Synthesis of Human Amylin 1–37 (2012) (0)
- The interaction of CGRP with its receptors (2002) (0)
- Comment on Yoo et al. Amylin Protein Expression in the Rat Brain and Neuro-2a Cells. Int. J. Mol. Sci. 2022, 23, 4348 (2023) (0)
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