Deborah Zamble
Canadian chemist
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Chemistry
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(Suggest an Edit or Addition)According to Wikipedia, Deborah Beth Zamble was a Canadian chemist and Canada Research Chair in Biological Chemistry at the University of Toronto. Her research considered how bacteria processed metal nutrients. Early life and education Zamble was born in Kingston, Ontario. She attended the University of Toronto for her undergraduate studies, where she worked in the lab of the Bibudhendra Sarkar. Zamble was a graduate student at the Massachusetts Institute of Technology, where she worked with Stephen J. Lippard on cisplatin, an anti-cancer drug. Her research considered the role of p53 in the cellular response to the drug. Zamble was a postdoctoral fellow at the Harvard Medical School, where she worked alongside Christopher T. Walsh. At the Harvard Medical School Zamble worked on the microcin B17 synthetase.
Deborah Zamble's Published Works
Published Works
- Cisplatin and DNA repair in cancer chemotherapy. (1995) (488)
- Repair of cisplatin--DNA adducts by the mammalian excision nuclease. (1996) (335)
- HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. (1994) (334)
- Nickel homeostasis and nickel regulation: an overview. (2009) (172)
- p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells. (1998) (145)
- The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. (2001) (127)
- A Role for SlyD in the Escherichia coli Hydrogenase Biosynthetic Pathway* (2005) (124)
- NikR–operator complex structure and the mechanism of repressor activation by metal ions (2006) (109)
- Metallocenter assembly of the hydrogenase enzymes. (2007) (97)
- Selectivity of metal binding and metal-induced stability of Escherichia coli NikR. (2004) (90)
- Microbial nickel proteins. (2010) (87)
- The polymerization behavior of [1]- and [2]ferrocenophanes containing silicon atoms in the bridge: comparison of the molecular structure of the strained, polymerizable cyclic ferrocenylsilane Fe(.eta.-C5H4)2(SiMe2) with that of the cyclic ferrocenyldisilane Fe(.eta.-C5H4)2(SiMe2)2 (1993) (84)
- Metal-selective DNA-binding response of Escherichia coli NikR. (2004) (81)
- [NiFe]-Hydrogenase Maturation. (2016) (79)
- The Role of Complex Formation between the Escherichia coli Hydrogenase Accessory Factors HypB and SlyD* (2007) (78)
- Metal binding activity of the Escherichia coli hydrogenase maturation factor HypB. (2005) (76)
- Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities. (1998) (75)
- Testis-specific HMG-domain protein alters the responses of cells to cisplatin. (2002) (70)
- Escherichia coli HypA Is a Zinc Metalloprotein with a Weak Affinity for Nickel (2005) (69)
- Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain. (1994) (69)
- The metal- and DNA-binding activities of Helicobacter pylori NikR. (2006) (62)
- The responses of cellular proteins to cisplatin-damaged DNA (1999) (55)
- Relationship between Ni(II) and Zn(II) Coordination and Nucleotide Binding by the Helicobacter pylori [NiFe]-Hydrogenase and Urease Maturation Factor HypB* (2013) (47)
- Structural basis of the metal specificity for nickel regulatory protein NikR. (2008) (47)
- Structural and biological analysis of the metal sites of Escherichia coli hydrogenase accessory protein HypB. (2008) (43)
- In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites (2001) (43)
- YeiR: a metal-binding GTPase from Escherichia coli involved in metal homeostasis. (2012) (42)
- Metal Binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases (2013) (42)
- Nickel metallomics: general themes guiding nickel homeostasis. (2013) (42)
- Escherichia coli SlyD, more than a Ni(II) reservoir. (2011) (40)
- The Ni(II)-binding properties of the metallochaperone SlyD. (2009) (40)
- A high-affinity metal-binding peptide from Escherichia coli HypB. (2008) (38)
- Protein Interactions and Localization of the Escherichia coli Accessory Protein HypA during Nickel Insertion to [NiFe] Hydrogenase* (2011) (37)
- Effects of Metal on the Biochemical Properties of Helicobacter pylori HypB, a Maturation Factor of [NiFe]-Hydrogenase and Urease (2011) (37)
- A High Throughput Method for the Detection of Metalloproteins on a Microgram Scale* (2005) (36)
- Mechanism of Selective Nickel Transfer from HypB to HypA, Escherichia coli [NiFe]-Hydrogenase Accessory Proteins. (2016) (36)
- Metal transfer within the Escherichia coli HypB-HypA complex of hydrogenase accessory proteins. (2013) (35)
- pH-responsive DNA-binding activity of Helicobacter pylori NikR. (2009) (35)
- Microbial nickel: cellular uptake and delivery to enzyme centers. (2017) (35)
- Relationship between the GTPase, metal-binding, and dimerization activities of E. coli HypB (2011) (35)
- Interactions of the Escherichia coli hydrogenase biosynthetic proteins: HybG complex formation (2006) (35)
- A high-performance liquid chromatography method for determining transition metal content in proteins. (2004) (34)
- The Escherichia coli metal‐binding chaperone SlyD interacts with the large subunit of [NiFe]‐hydrogenase 3 (2011) (32)
- Acid-responsive activity of the Helicobacter pylori metalloregulator NikR (2018) (29)
- The Peptidyl-Prolyl Isomerase Activity of SlyD Is Not Required for Maturation of Escherichia coli Hydrogenase (2007) (25)
- The "metallo-specific" response of proteins: a perspective based on the Escherichia coli transcriptional regulator NikR. (2009) (24)
- Protease digestion analysis of Escherichia coli NikR: evidence for conformational stabilization with Ni(II) (2005) (24)
- The McbB component of microcin B17 synthetase is a zinc metalloprotein. (2000) (23)
- Nickel binding and [NiFe]-hydrogenase maturation by the metallochaperone SlyD with a single metal-binding site in Escherichia coli. (2012) (21)
- The Biological Chemistry of Nickel (2017) (20)
- The metal selectivity of a short peptide maquette imitating the high-affinity metal-binding site of E. coli HypB. (2012) (20)
- Metal selectivity of the Escherichia coli nickel metallochaperone, SlyD. (2011) (18)
- Synthesis, structures, and the redistribution and skeletal cleavage reactions of siloxane-bridged ferrocenophanes (1994) (18)
- Nickel-responsive regulation of two novel Helicobacter pylori NikR-targeted genes. (2015) (18)
- Microbial Physiology of Nickel and Cobalt (2007) (17)
- Analyzing the 3D Structure of Human Carbonic Anhydrase II and Its Mutants Using Deep View and the Protein Data Bank (2005) (13)
- Allosteric control of metal-responsive transcriptional regulators in bacteria (2019) (13)
- Potassium is critical for the Ni(II)-responsive DNA-binding activity of Escherichia coli NikR. (2010) (13)
- CHAPTER 1:Introduction to the Biological Chemistry of Nickel (2017) (11)
- Nonspecific interactions between Escherichia coli NikR and DNA are critical for nickel-activated DNA binding. (2012) (11)
- High-affinity metal binding by the Escherichia coli [NiFe]-hydrogenase accessory protein HypB is selectively modulated by SlyD. (2017) (11)
- The response of Escherichia coli NikR to nickel: a second nickel-binding site. (2010) (11)
- Bimodal Nickel-Binding Site on Escherichia coli [NiFe]-Hydrogenase Metallochaperone HypA. (2019) (9)
- The impact of a His-tag on DNA binding by RNA polymerase alpha-C-terminal domain from Helicobacter pylori. (2019) (9)
- Complex formation between the Escherichia coli [NiFe]-hydrogenase nickel maturation factors (2019) (8)
- Allosteric control of metal-responsive transcriptional regulators in bacteria. (2020) (8)
- Fluorescence analysis of sulfonamide binding to carbonic anhydrase (2006) (8)
- A novel mode of control of nickel uptake by a multifunctional metallochaperone (2021) (7)
- Nickel in biology. (2015) (7)
- A whole-cell, high-throughput hydrogenase assay to identify factors that modulate [NiFe]-hydrogenase activity (2019) (6)
- High throughput methods for analyzing transition metals in proteins on a microgram scale. (2008) (5)
- Microbial Nickel Proteins (2010) (4)
- Demonstration of the anti-bacterial properties of the latex obtained by tapping the trunks of Alafia multiflora trees. Identification of vanillic acid. (1980) (3)
- It costs more than a nickel (2015) (3)
- Faculty Opinions recommendation of Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. (2019) (2)
- Allosteric regulation of the nickel-responsive NikR transcription factor from Helicobacter pylori. (2020) (2)
- Nickel Homeostasis: Mechanism and function of NikR (2013) (2)
- Allosteric regulation of the nickel-responsive NikR transcription factor from Helicobacter pylori (2020) (2)
- Protein‐Protein Interactions in Nickel Acquisition of Escherichia coli (2017) (1)
- Mechanistic insights into the nickel-dependent allosteric response of the Helicobacter pylori NikR transcription factor (2022) (0)
- Using a high - throughput, whole - cell hydrogenase assay to identify potential small molecule inhibitors of [NiFe] - hydrogenase. (2022) (0)
- Biological mechanisms of cisplatin cytotoxicity (1997) (0)
- Identification of Nvp-Bkm120 As a Potent, Selective, Orally Bioavailable Class I P13 Kinase Inhibitor for Treating Cancer (2013) (0)
- The Science of the Modern Kitchen (2023) (0)
- Correction to Metal Binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases (2013) (0)
- Faculty Opinions recommendation of Formyltetrahydrofolate Decarbonylase Synthesizes the Active Site CO Ligand of O2-Tolerant [NiFe] Hydrogenase. (2020) (0)
- Faculty Opinions recommendation of Uropathogenic enterobacteria use the yersiniabactin metallophore system to acquire nickel. (2018) (0)
- The Effects of Metal on the Biochemical Properties of (2011) (0)
- Faculty Opinions recommendation of Biphasic unbinding of a metalloregulator from DNA for transcription (de)repression in Live Bacteria. (2020) (0)
- Non-zinc finger residues specify retinoic acid and retinoid X receptor heterodimer interfaces (1993) (0)
- Nickel Homeostasis and Nickel Regulation: An Overview (2010) (0)
- Faculty Opinions recommendation of Antimicrobial action of calprotectin that does not involve metal withholding. (2019) (0)
- Complex formation between the Escherichia coli [NiFe]-hydrogenase nickel maturation factors (2019) (0)
- Genome‐Wide Screen for Escherichia coli [NiFe]‐Hydrogenase Maturation Factors (2017) (0)
- Structural Changes in the Nickel‐Responsive Regulator NikR from Helicobacter pylori (2017) (0)
- Disrupting the Non-specific Interactions between DNA and the Escherichia coli Transcriptional Repressor NikR (2012) (0)
- Biochemical studies highlight determinants for metal selectivity in the Escherichia coli periplasmic solute binding protein NikA. (2022) (0)
- Crystal structure of HypB from Helicobacter pylori in complex with nickel (2013) (0)
- The Science of the Modern Kitchen. (2023) (0)
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