Deborah Dunn-Walters
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Deborah Dunn-Waltersbiology Degrees
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Immunology
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Biology
Deborah Dunn-Walters's Degrees
- PhD Immunology University of Oxford
- Bachelors Biomedical Science University of Oxford
Why Is Deborah Dunn-Walters Influential?
(Suggest an Edit or Addition)According to Wikipedia, Deborah Kay Dunn-Walters is a British immunologist who is Professor of Immunology at the University of Surrey. Her research considers B-cell development in healthy ageing and in disease, particularly from the viewpoint of antibody repertoires. During the COVID-19 pandemic, Dunn-Walters focussed on mapping responses to SARS-CoV-2 infection and the development of single cell analyses of the immunological responses to a COVID-19 vaccine. She was a member of the Scientific Advisory Group for Emergencies, and provided the government with scientific advice during the pandemic.
Deborah Dunn-Walters's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- B-cell diversity decreases in old age and is correlated with poor health status (2009) (377)
- Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells (1995) (304)
- High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. (2010) (283)
- Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity (2014) (193)
- B cells and aging: molecules and mechanisms. (2009) (178)
- The Relationship between CD27 Negative and Positive B Cell Populations in Human Peripheral Blood (2011) (139)
- Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages (2011) (132)
- Mechanisms of immunosenescence (2009) (130)
- The ageing B cell population: Composition and function (2010) (125)
- Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination (2012) (103)
- Age‐ and tissue‐specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees (2002) (94)
- B cell repertoire and ageing. (2010) (93)
- Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells (1997) (92)
- Human marginal-zone B cells. (1998) (91)
- Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches (1997) (89)
- A Reassessment of IgM Memory Subsets in Humans (2015) (86)
- B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans (2011) (83)
- Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response (2018) (82)
- B cell immunosenescence: different features of naive and memory B cells in elderly (2011) (80)
- Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions. (2000) (70)
- Ageing of the B-cell repertoire (2015) (66)
- Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells. (1996) (63)
- Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators. (1999) (62)
- IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans. (2011) (61)
- Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases. (2010) (61)
- Yersinia enterocolitica Provides the Link between Thyroid-Stimulating Antibodies and Their Germline Counterparts in Graves’ Disease (2013) (56)
- Characteristics of Human IgA and IgM Genes Used by Plasma Cells in the Salivary Gland Resemble Those Used in Duodenum But Not Those Used in the Spleen1 (2000) (55)
- The ageing human B cell repertoire: a failure of selection? (2016) (55)
- Human lymphocyte repertoires in ageing. (2013) (54)
- Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues (2016) (54)
- Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation. (1998) (52)
- The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees (2002) (51)
- Antibody quality in old age. (2006) (51)
- Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC (2010) (48)
- Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses. (2010) (47)
- Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes. (1998) (46)
- Effects of age on antibody affinity maturation. (2003) (45)
- Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions (2016) (45)
- A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient (2013) (43)
- Transitional B Cells in Early Human B Cell Development – Time to Revisit the Paradigm? (2016) (43)
- Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation (2006) (42)
- Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways (2020) (41)
- CD1d‐mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis (2018) (40)
- IGHV1, IGHV5 and IGHV7 subgroup genes in the Rhesus macaque (2003) (38)
- Somatic hypermutation and B-cell lymphoma. (2001) (34)
- Hypermutation at A-T Base Pairs: The A Nucleotide Replacement Spectrum Is Affected by Adjacent Nucleotides and There Is No Reverse Complementarity of Sequences Flanking Mutated A and T Nucleotides12 (2005) (34)
- Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth (2020) (33)
- Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis (2002) (33)
- Immune Responses: Primary and Secondary (2010) (32)
- Immunoglobulin gene analysis as a tool for investigating human immune responses (2018) (32)
- Correction: Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis (2012) (32)
- Age‐related aspects of human IgM+ B cell heterogeneity (2015) (31)
- Immunohistochemical analysis of ageing human B and T cell populations reveals an age-related decline of CD8 T cells in spleen but not gut-associated lymphoid tissue (GALT) (2000) (29)
- Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees. (2004) (26)
- Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection. (2006) (26)
- B‐cell clonal diversification and gut‐lymph node trafficking in ulcerative colitis revealed using lineage tree analysis (2008) (26)
- Immunoglobulin Gene Repertoire Diversification and Selection in the Stomach – From Gastritis to Gastric Lymphomas (2014) (26)
- BRepertoire: a user-friendly web server for analysing antibody repertoire data (2018) (23)
- Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections (1996) (23)
- Somatic hypermutation and B‐cell malignancies (1999) (23)
- Lambda Light Chain Revision in the Human Intestinal IgA Response1 (2008) (23)
- B cell development and proliferation of mature B cells in human fetal intestine (2002) (22)
- Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer (2021) (22)
- Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4‐34 usage in mucosa‐associated lymphoid tissue lymphoma (2017) (21)
- Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases. (2006) (20)
- Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue. (2009) (20)
- Assessment of B Cell Repertoire in Humans. (2015) (19)
- Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV and IGKV3 (2005) (18)
- Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue (1996) (18)
- Immunoglobulin light-chain genes in the rhesus macaque II: lambda light-chain germline sequences for subgroups IGLV1, IGLV2, IGLV3, IGLV4 and IGLV5 (2005) (17)
- Promiscuous antibodies characterised by their physico-chemical properties: From sequence to structure and back (2017) (16)
- A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation (2008) (16)
- BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome (2013) (15)
- Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus. (2015) (15)
- Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus (2015) (15)
- Significant association between TNFAIP3 inactivation and biased IGHV4-34 usage in MALT lymphoma (2017) (12)
- Human tonsillar germinal center T cells are a diverse and widely disseminated population (1999) (11)
- Biased JH usage in plasma cell immunoglobulin gene sequences from colonic mucosa in ulcerative colitis but not in Crohn’s disease (1999) (11)
- Age-Related Changes in B Cells Relevant to Vaccine Responses. (2020) (10)
- Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response. (2015) (10)
- Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming? (2009) (9)
- Immunoglobulin genes from human duodenal and colonic plasma cells are mutated. (1997) (9)
- Untargeted saliva metabolomics reveals COVID-19 severity: Saliva Metabolomics for SARS-COV-2 Prognosis (2021) (8)
- PCR amplification and high throughput sequencing of immunoglobulin heavy chain genes from formalin-fixed paraffin-embedded human biopsies. (2013) (8)
- Metabolomics Markers of COVID-19 Are Dependent on Collection Wave (2022) (6)
- Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in‐frame and highly mutated and most kappa genes are highly mutatedwhen in‐frame and minimally mutated when out‐of‐frame (2000) (6)
- CSF1R defines the mononuclear phagocyte system lineage in human blood in health and COVID-19 (2021) (6)
- Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid Treatment (2022) (5)
- The ageing gut (2004) (4)
- Clonal relationships between thyroid‐stimulating hormone receptor‐stimulating antibodies illustrate the effect of hypermutation on antibody function (2010) (4)
- Human B Cell Senescence in Pulmonary Infections (2012) (4)
- Dual role for Bcl-2 in antibody affinity maturation (2005) (3)
- Untargeted saliva metabolomics by liquid chromatography—Mass spectrometry reveals markers of COVID-19 severity (2022) (3)
- Addendum: Immunoglobulin Gene Repertoire Diversification and Selection in the Stomach – From Gastritis to Gastric Lymphomas (2014) (3)
- Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV2 and IGKV3 (2005) (3)
- Selected Antibodies Protect the Human Intestinal Mucosa (1998) (2)
- Understanding the Mechanisms of Immune System Aging: Immune System Cell Development and Antibody Repertoires (2014) (2)
- immunoglobulin class switch recombination and somatic hypermutation (2006) (2)
- Natural IgE promotes epithelial hyperplasia and inflammation-driven tumour growth (2019) (1)
- Immunoglobulin A-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans. (2010) (1)
- B-Cells and Antibodies in Old Humans (2008) (1)
- Lineage tree analysis of high throughput immunoglobulin sequencing clarifies B cell maturation pathways (2015) (1)
- Igtree (c) and mtree (c): creating and quantifying immunoglobulin variable region gene lineage trees (2007) (1)
- Older Human B Cells and Antibodies (2019) (1)
- Genes HOut-of-Frame Human IgV Hypermutation Deduced by Analysis of Base-Specific Sequences That Bias Somatic (1998) (1)
- Older Human B Cells and Antibodies (2017) (1)
- Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus (2021) (1)
- sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data (2023) (0)
- Correction: Table II. (2006) (0)
- High-Throughput Ig Sequencing of Paired Blood and Spleen Samples Allows a Redefinition of Memory IgM Subsets in Humans (2014) (0)
- A new humanIghV4.21-related pseudogene capable ofVDJ rearrangement (1996) (0)
- Chickens, more than humans, focus the diversity of their immunoglobulin genes on the complementarity-determining region but utilise amino acids, indicative of a more cross-reactive antibody repertoire (2022) (0)
- But Not Those Used in the Spleen Gland Resemble Those Used in Duodenum Genes Used by Plasma Cells in the Salivary Characteristics of Human IgA and IgM (2000) (0)
- Differences in hypermutation of human antibody genes with age (2001) (0)
- Humansof IgM Memory Subsets in (2015) (0)
- TCR or BCR CDR3 spectratypes differ between blood and spleen and between old and young patients, and can be used to detect myelodysplastic syndrome (2012) (0)
- Author response: Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth (2019) (0)
- Immunogenetics and transplantation. (2013) (0)
- Roles of repertoire diversity in robustness of humoral immune response (2019) (0)
- Mutations in VH 3-23C γ transcripts from PBL from ATRD patients (0)
- Making ill health in old age a thing of the past (2019) (0)
- Immune system changes and immunosenescence (2017) (0)
- A new human IghV4.21-related pseudogene capable of V D J rearrangement (1996) (0)
- Diversification of Immunoglobulin genes by Gene Conversion in the Domestic Chicken (Gallus gallus domesticus) (2023) (0)
- Sequence analysis ofimmunoglobulin variable region genes thatencode autoantibodies expressed bylymphomas ofmucosa associated lymphoid tissue (1996) (0)
- Germinal center reaction (PP-031) (2010) (0)
- Five researchers working on lifelong health in very different ways (2020) (0)
- Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response (2018) (0)
- Promiscuity and Polyreactivity of Antibodies and their Binding Modes during B-Cell Differentiation (2016) (0)
- Correction. Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus. (2015) (0)
- Clonal relationships between TSH receptor stimulating antibodies illustrate the effect of hypermutation on antibody function (2009) (0)
- Addendum: Immunoglobulin Gene Repertoire Diversification and Selection in the Stomach – From Gastritis to Gastric Lymphomas (2015) (0)
- Differences in hypermutation of human immunoglobulin VH genes with age (2000) (0)
- Editorial: New Insights Into B Cell Subsets in Health and Disease (2022) (0)
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