Deborah K. Morrison
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American cell biologist
Deborah K. Morrison's AcademicInfluence.com Rankings
Deborah K. Morrisonbiology Degrees
Biology
#10730
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#14083
Historical Rank
#2518
USA Rank
Cell Biology
#622
World Rank
#635
Historical Rank
#75
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Molecular Biology
#1907
World Rank
#1938
Historical Rank
#228
USA Rank
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Biology
Deborah K. Morrison's Degrees
- PhD Cell Biology Stanford University
- Masters Biology University of California, Berkeley
- Bachelors Biology University of California, Berkeley
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Why Is Deborah K. Morrison Influential?
(Suggest an Edit or Addition)According to Wikipedia, Deborah Kay Morrison is an American cell biologist who is the chief of the Laboratory of Cell and Developmental Signaling at the National Cancer Institute. She conducts research characterizing the RAS pathway and the RAF family kinases and leads efforts to design new therapeutic strategies for cancer treatment.
Deborah K. Morrison's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase (1995) (2107)
- Comparative genomics of the eukaryotes. (2000) (1031)
- MAP kinase pathways. (2012) (825)
- Regulation of MAP kinase signaling modules by scaffold proteins in mammals. (2003) (824)
- The complexity of Raf-1 regulation. (1997) (652)
- Integrating signals from RTKs to ERK/MAPK (2007) (620)
- Regulation of Raf-1 by direct feedback phosphorylation. (2005) (589)
- The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. (2009) (581)
- Unlocking the code of 14-3-3 (2004) (498)
- PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex (1990) (390)
- Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor (1989) (376)
- Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. (1988) (370)
- Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase (1993) (366)
- Identification of the major phosphorylation sites of the Raf-1 kinase. (1993) (326)
- Raf functions downstream of Rasl in the Sevenless signal transduction pathway (1992) (313)
- Protein Phosphatase 2A Positively Regulates Ras Signaling by Dephosphorylating KSR1 and Raf-1 on Critical 14-3-3 Binding Sites (2003) (312)
- C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (2001) (289)
- Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo (2002) (285)
- KSR modulates signal propagation within the MAPK cascade. (1996) (267)
- The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase (1989) (247)
- Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 (2000) (244)
- Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy. (2012) (243)
- Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate (1988) (242)
- KSR: a MAPK scaffold of the Ras pathway? (2001) (239)
- 14-3-3 Proteins: diverse functions in cell proliferation and cancer progression. (2011) (216)
- Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression (1999) (212)
- 14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner (1995) (210)
- Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. (1995) (199)
- Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling (2009) (195)
- Nm23-H1 Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway* (2002) (190)
- AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation (1995) (173)
- KSR stimulates Raf-1 activity in a kinase-independent manner. (1997) (172)
- Autoregulation of the Raf-1 serine/threonine kinase. (1998) (168)
- A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. (1994) (167)
- Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling. (2013) (167)
- Protein Kinases and Phosphatases in the Drosophila Genome (2000) (162)
- Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex (1990) (156)
- Signaling dynamics of the KSR1 scaffold complex (2009) (152)
- Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes (1993) (148)
- Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro (1995) (138)
- KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. (2009) (137)
- The role of Raf-1 phosphorylation in signal transduction. (1992) (125)
- AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade (2010) (113)
- KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. (2009) (112)
- Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling (2000) (103)
- CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase Activation (2007) (100)
- Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. (1998) (99)
- Kinase Suppressor of Ras1 Compartmentalizes Hippocampal Signal Transduction and Subserves Synaptic Plasticity and Memory Formation (2006) (98)
- Ras-Mediated Activation of the Raf Family Kinases. (2019) (98)
- A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. (2000) (92)
- Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner. (1994) (91)
- Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR). (2002) (89)
- 95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site (1992) (84)
- Functional analysis of C‐TAK1 substrate binding and identification of PKP2 as a new C‐TAK1 substrate (2003) (81)
- Targeting the Raf kinases in human cancer: the Raf dimer dilemma (2017) (75)
- RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling (2011) (74)
- The importance of Raf dimerization in cell signaling (2013) (74)
- Mechanisms regulating Raf‐1 activity in signal transduction pathways (1995) (73)
- FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4 (2013) (72)
- The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling. (2010) (72)
- Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit. (2016) (68)
- Identification of a Src Tyrosine Kinase/SIAH2 E3 Ubiquitin Ligase Pathway That Regulates C/EBPδ Expression and Contributes to Transformation of Breast Tumor Cells (2011) (67)
- Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation (2004) (66)
- A Whole-Genome Assembly of Drosophila (2000) (63)
- Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. (2003) (61)
- HDM2 phosphorylation by MAPKAP kinase 2 (2005) (61)
- Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling. (2019) (59)
- Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction (1993) (59)
- Signal Transduction: IMPlications for Ras-Dependent ERK Signaling (2004) (58)
- BCL-2 and BCL-XL Restrict Lineage Choice during Hematopoietic Differentiation* (2003) (54)
- Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. (2015) (50)
- Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK. (1996) (49)
- The CNK2 Scaffold Interacts with Vilse and Modulates Rac Cycling during Spine Morphogenesis in Hippocampal Neurons (2014) (48)
- Characterization of Raf-1 Activation in Mitosis* (1999) (48)
- dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. (2003) (47)
- Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity* (1998) (45)
- CCAAT/enhancer binding protein delta (C/EBPδ, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage (2010) (42)
- Tyrosine phosphorylations in vivo associated with v-fms transformation (1988) (42)
- Faculty Opinions recommendation of A structural basis for 14-3-3sigma functional specificity. (2005) (38)
- Detection of a subunit of cellular Pol II within highly purified preparations of RNA polymerase isolated from rabbit poxvirus virions (1986) (36)
- Advancing RAS/RASopathy therapies: An NCI‐sponsored intramural and extramural collaboration for the study of RASopathies (2019) (36)
- The immunophilin FKBP65 forms an association with the serine/threonine kinase c-Raf-1. (1998) (35)
- MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity (2017) (35)
- Signal transduction downstream from Ras in Drosophila. (1997) (35)
- Faculty Opinions recommendation of PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (2005) (35)
- Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. (2019) (31)
- LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation. (2012) (30)
- Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases. (1994) (29)
- Isolation and characterization of monoclonal antibodies directed against two subunits of rabbit poxvirus-associated, DNA-directed RNA polymerase (1985) (28)
- A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane (2012) (27)
- Raf-1 Without MEK? (2001) (25)
- Sequential Modification of Serines 621 and 624 in the Raf-1 Carboxyl Terminus Produces Alterations in Its Electrophoretic Mobility* (1997) (25)
- Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation (2018) (25)
- Overexpression of Kinase Suppressor of Ras Upregulates the High-Molecular-Weight Tropomyosin Isoforms in ras-Transformed NIH 3T3 Fibroblasts (2003) (25)
- The Raf-1 kinase as a transducer of mitogenic signals. (1990) (25)
- The activity of D-raf in torso signal transduction is altered by serine substitution, N-terminal deletion, and membrane targeting. (1996) (25)
- EphrinB1 Interacts with CNK1 and Promotes Cell Migration through c-Jun N-terminal Kinase (JNK) Activation* (2014) (24)
- Complexity in KSR function revealed by Raf inhibitor and KSR structure studies (2011) (24)
- Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma* (2016) (24)
- M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell–cell adhesion during collective cell migration (2019) (21)
- KSR 2 Is An Essential Regulator of AMP Kinase , Energy Expenditure , and Insulin Sensitivity (2003) (21)
- Caspase-dependent Cleavage Disrupts the ERK Cascade Scaffolding Function of KSR1*♦ (2007) (20)
- KSR regulation of the Raf-MEK-ERK cascade. (2006) (20)
- Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding (2021) (19)
- Mammalian Raf‐1 is activated by mutations that restore Raf signaling in Drosophila (1997) (17)
- Activation of Raf-1 by Ras in intact cells. (1995) (17)
- Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets. (2018) (15)
- TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin. (2021) (14)
- KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. (2017) (14)
- Path Forward for RAF Therapies: Inhibition of Monomers and Dimers. (2015) (11)
- Signal transduction by receptor tyrosine kinases. (1992) (10)
- Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling. (2018) (10)
- A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation (2022) (9)
- Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction. (2020) (8)
- Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. (1999) (8)
- Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway * (2002) (8)
- Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation (2022) (8)
- Cancer: Enzymes play molecular tag (2004) (8)
- Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma (2020) (7)
- Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2 (2017) (6)
- Recruitment to the cytoplasm of a cellular lamin-like protein from the nucleus during a poxvirus infection. (1989) (5)
- Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling (2018) (5)
- Proteomic analysis of scaffold proteins in the ERK cascade. (2010) (5)
- Assay of Raf-1 activity. (2002) (5)
- Abstract LB-108: Targeting the Ras-Binding domain of RAS effector proteins by a small molecule inhibitor, Rigosertib (2014) (4)
- Mechanisms and Potential Therapies for Acquired Resistance to Inhibitors Targeting the Raf or MEK Kinases in Cancer (2013) (3)
- mechanisms in vitro . Ras-dependent and Ras-independent Regulation of Raf-1 and Raf-1 mutants (1995) (3)
- Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction (2021) (3)
- Solution structure of the cysteine-rich C1 domain of Kinase Suppressor of Ras (2002) (2)
- Regulation of GTPase function by autophosphorylation (2021) (2)
- RAS signaling: Divide and conquer. (2016) (2)
- RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation. (2022) (2)
- that Regulates C/EBPδ Expression and Contributes to Transformation of (2011) (1)
- Regulation of GTPase function by autophosphorylation. (2022) (1)
- Faculty Opinions recommendation of Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (2008) (1)
- RASopathy Mutations Demonstrate the Critical Function of the Cysteine-rich Domain in Maintaining BRAF in an Autoinhibited State (2021) (1)
- RAS and the RAF/MEK/ERK Cascade (2006) (1)
- Faculty Opinions recommendation of JunD mediates survival signaling by the JNK signal transduction pathway. (2003) (0)
- Abstract IA17: Molecular mechanisms that regulate Raf kinase signaling (2020) (0)
- Abstract A11: Oncogenic Ras signaling involves sustained perinuclear localization of the effector kinases p-ERK1/2 and CK2 via KSR-1 and endosomal trafficking (2014) (0)
- Faculty Opinions recommendation of Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. (2008) (0)
- RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation (2022) (0)
- TNIK, a novel activator of FAK and YAP signaling, is a therapeutic target in Lung Squamous Cell Carcinoma (2021) (0)
- Faculty Opinions recommendation of A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. (2007) (0)
- The protein kinase TNIK: a novel druggable target in Lung Squamous Cell Carcinoma with 3q amplification. (2020) (0)
- Abstract PR06: Germline RASopathy mutations provide insights into the differential regulation of RAF family kinases (2023) (0)
- Abstract 2152: TNIK, a novel activator of FAK and YAP signaling, is a therapeutic target in lung squamous cell carcinoma (2022) (0)
- In Vivo Mitogen-Activated Protein Kinase Activation Scaffold Which Facilitates Kinase Suppressor of Ras (KSR) Is a (2014) (0)
- Abstract 1239: Differential effects of dimerization on B-Raf and C-Raf function revealed by mutational analysis and peptide inhibitors that target the Raf dimer interface (2012) (0)
- Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding (2022) (0)
- Faculty Opinions recommendation of Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. (2003) (0)
- Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum. (2022) (0)
- Regulation of RAS function by active site autophosphorylation (2021) (0)
- Ras-independent manner. biologically activated in a 14-3-3- and identification of Raf-1 proteins that are 14-3-3 is not essential for Raf-1 function: (2013) (0)
- Abstract A35: Oncogenic Ras signaling involves formation of perinuclear CK2α nd p-ERK1/2 signaling complexes that require the KSR-1 scaffold protein and endosomal trafficking (2016) (0)
- Faculty Opinions recommendation of Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. (2005) (0)
- Growth factor signaling regulation of a Rab-effector switch required for ciliogenesis initiation. (2016) (0)
- Abstract A31: Germline RASopathy mutations provide functional insights into the Raf cysteine-rich domain (CRD) (2020) (0)
- Faculty Opinions recommendation of The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. (2006) (0)
- Autoregulation of the Raf-1 serine y threonine kinase ( signal transduction (1998) (0)
- Abstract 84: Characterization of oncogenic KRAS A59 alleles and their cooperation with the MAPK signaling pathway (2021) (0)
- Faculty Opinions recommendation of Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. (2007) (0)
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