Denise Kirschner | Academic Influence

Denise Kirschner's AcademicInfluence.com Rankings

Denise Kirschner

Biology

#2385

World Rank

#3790

Historical Rank

Mathematical Biology

#12

World Rank

#14

Historical Rank

Immunology

#359

World Rank

#373

Historical Rank

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Biology

Denise Kirschner's Degrees

PhD Applied Mathematics University of Maryland, College Park
Bachelors Mathematics University of Maryland, College Park

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Why Is Denise Kirschner Influential?

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According to Wikipedia, Denise Ellen Kirschner is an American mathematical biologist and immunologist whose research topics include granulomas, HIV, tuberculosis, and the mechanisms by which disease pathogens interact with and persist in their hosts. She is a professor of microbiology and immunology at the University of Michigan, co-editor-in-chief of the Journal of Theoretical Biology, and former president of the Society for Mathematical Biology.

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Denise Kirschner's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A methodology for performing global uncertainty and sensitivity analysis in systems biology. (2008) (1944)
Dynamics of HIV infection of CD4+ T cells. (1993) (867)
Modeling immunotherapy of the tumor – immune interaction (1998) (795)
Optimal control of the chemotherapy of HIV (1997) (504)
Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. (2004) (306)
Mathematical Approaches for Emerging and Reemerging Infectious Diseases: An Introduction (2002) (287)
Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms (2013) (278)
A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis1 (2001) (254)
Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization (2015) (243)
The equilibria that allow bacterial persistence in human hosts (2007) (212)
Using Mathematics to Understand HIV Immune Dynamics (1997) (210)
A mathematical model of tumor-immune evasion and siRNA treatment (2003) (189)
Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation (2011) (168)
The human immune response to Mycobacterium tuberculosis in lung and lymph node. (2004) (164)
Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs (2008) (157)
Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection1 (2009) (152)
Systems biology of persistent infection: tuberculosis as a case study (2008) (150)
Dendritic Cell Trafficking and Antigen Presentation in the Human Immune Response to Mycobacterium tuberculosis 1 (2004) (139)
Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection (2014) (136)
Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology (2018) (132)
A model for treatment strategy in the chemotherapy of AIDS. (1996) (131)
Reevaluation of T Cell Receptor Excision Circles as a Measure of Human Recent Thymic Emigrants1 (2002) (130)
Dynamics of co-infection with M. Tuberculosis and HIV-1. (1999) (129)
Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis. (2007) (129)
Dynamics of Helicobacter pylori colonization in relation to the host response. (1999) (122)
The dynamics of Helicobacter pylori infection of the human stomach. (1995) (119)
Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection (2013) (104)
Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo (2013) (104)
Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue (2007) (96)
A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis. (2011) (93)
NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis (2012) (90)
TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model. (2010) (90)
Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability (2012) (89)
A Mathematical Model of Combined Drug Therapy of HIV Infection (1997) (86)
Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection. (2006) (85)
Contribution of CD8+ T Cells to Control of Mycobacterium tuberculosis Infection1 (2006) (85)
Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages. (2005) (83)
The thymus during HIV disease: role in pathogenesis and in immune recovery. (2004) (83)
Strategies for Efficient Numerical Implementation of Hybrid Multi-scale Agent-Based Models to Describe Biological Systems (2015) (82)
Comparing epidemic tuberculosis in demographically distinct heterogeneous populations. (2002) (80)
Toward a multiscale model of antigen presentation in immunity (2007) (80)
Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes. (2000) (76)
Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression. (2002) (75)
Mathematical analysis of the global dynamics of a model for HTLV-I infection and ATL progression. (2002) (71)
A Model for the Immune System Response to HIV: AZT Treatment Studies (1993) (71)
Understanding drug resistance for monotherapy treatment of HIV infection (1997) (70)
On the global dynamics of a model for tumor immunotherapy. (2009) (68)
Live attenuated HIV vaccines: Predicting the tradeoff between efficacy and safety (2001) (67)
Immunotherapy of HIV-1 Infection (1998) (66)
Characterizing the Dynamics of CD4+ T Cell Priming within a Lymph Node (2010) (63)
Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection (2015) (61)
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment. (2015) (60)
Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma (2010) (59)
A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning. (2008) (59)
Peptide length-based prediction of peptide-MHC class II binding (2006) (59)
A multifaceted approach to modeling the immune response in tuberculosis (2011) (59)
Predicting differential responses to structured treatment interruptions during HAART (2004) (59)
Understanding the Immune Response in Tuberculosis Using Different Mathematical Models and Biological Scales (2005) (58)
On treatment of tuberculosis in heterogeneous populations. (2003) (57)
Role of the thymus in pediatric HIV-1 infection. (1998) (56)
Mathematical and computational approaches can complement experimental studies of host–pathogen interactions (2008) (56)
Predicting lymph node output efficiency using systems biology. (2013) (54)
Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models (2014) (54)
Influence of backward bifurcation on interpretation of r(0) in a model of epidemic tuberculosis with reinfection. (2004) (52)
Modeling socio-demography to capture tuberculosis transmission dynamics in a low burden setting. (2011) (52)
Data-parallel algorithms for agent-based model simulation of tuberculosis on graphics processing units (2009) (50)
Chemokine and Cytokine Mediated Loss of Regulatory T Cells in Lymph Nodes during Pathogenic Simian Immunodeficiency Virus Infection1 (2008) (50)
Theoretical and experimental approaches for studying factors defining the Helicobacter pylori-host relationship. (2000) (48)
A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment. (2017) (46)
A Mathematical Model of Gene Therapy for the Treatment of Cancer (2013) (46)
Predicting the second wave of COVID-19 in Washtenaw County, MI (2020) (46)
The coreceptor mutation CCR5Δ32 influences the dynamics of HIV epidemics and is selected for by HIV (2001) (45)
A model for treatment strategy in the chemotherapy of AIDS (1996) (45)
Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection. (2011) (44)
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach (2017) (44)
Tuberculosis: global approaches to a global disease. (2010) (42)
Harnessing the Heterogeneity of T Cell Differentiation Fate to Fine-Tune Generation of Effector and Memory T Cells (2014) (42)
Measuring emigration of human thymocytes by T-cell receptor excision circles. (2002) (42)
The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection. (2008) (42)
A model for integrative study of human gastric acid secretion. (2003) (40)
Resistance, remission, and qualitative differences in HIV chemotherapy. (1997) (39)
Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions (2016) (39)
Predicting the second wave of COVID-19 in Washtenaw County, MI (2020) (38)
In silico evaluation and exploration of antibiotic tuberculosis treatment regimens (2015) (38)
Macrophage response to Mycobacteriumtuberculosis infection (2004) (38)
The timing of TNF and IFN-gamma signaling affects macrophage activation strategies during Mycobacterium tuberculosis infection. (2008) (37)
A Multi-Compartment Hybrid Computational Model Predicts Key Roles for Dendritic Cells in Tuberculosis Infection (2016) (35)
Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome (2016) (34)
Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations (2019) (34)
Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis (2016) (33)
Mycobacterium tuberculosis as viewed through a computer. (2005) (32)
Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection. (2017) (32)
Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model (2017) (31)
IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection (2019) (30)
The role of delays in innate and adaptive immunity to intracellular bacterial infection. (2007) (29)
The Effects of HIV-1 Infection on Latent Tuberculosis (2008) (29)
Low Levels of T Cell Exhaustion in Tuberculous Lung Granulomas (2018) (29)
A multi-scale approach to designing therapeutics for tuberculosis. (2015) (27)
A metapopulation model of granuloma formation in the lung during infection with mycobacterium tuberculosis. (2005) (27)
The Roles of Immune Memory and Aging in Protective Immunity and Endogenous Reactivation of Tuberculosis (2013) (27)
Increased expression of interferon-inducible genes in macaque lung tissues during simian immunodeficiency virus infection. (2006) (27)
Timebomb: The Global Epidemic of Multi-Drug Resistant Tuberculosis (2001) (25)
New insights into mathematical modeling of the immune system (2006) (25)
Effect of Multiple Genetic Polymorphisms on Antigen Presentation and Susceptibility to Mycobacterium tuberculosis Infection (2008) (24)
Dose finding for new vaccines: The role for immunostimulation/immunodynamic modelling (2018) (23)
A model for the study of Helicobacter pylori interaction with human gastric acid secretion. (2004) (22)
Reconstitution of thymic function in HIV-1 patients treated with highly active antiretroviral therapy. (2003) (22)
Inoculation Dose of Mycobacterium tuberculosis Does Not Influence Priming of T Cell Responses in Lymph Nodes (2013) (21)
Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas (2020) (21)
Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation (2015) (21)
Systems Pharmacology Approach Toward the Design of Inhaled Formulations of Rifampicin and Isoniazid for Treatment of Tuberculosis (2015) (20)
A model for Vibrio cholerae colonization of the human intestine. (2011) (20)
Remarks on Modeling Host-Viral Dynamics and Treatment (2001) (18)
Global sensitivity analysis of biological multi-scale models. (2019) (18)
Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas (2018) (18)
Revisiting Early Models of the host-pathogen interactions in HIV infection (2000) (16)
In silico models of M. tuberculosis infection provide a route to new therapies. (2015) (16)
Applying Optimization Algorithms to Tuberculosis Antibiotic Treatment Regimens (2017) (15)
A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes. (2015) (15)
Evaluating vaccination strategies for tuberculosis in endemic and non-endemic settings. (2019) (15)
A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis (2013) (15)
Lack of good correlation of serum CC-chemokine levels with human immunodeficiency virus-1 disease stage and response to treatment. (2004) (15)
Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study (2016) (14)
Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation (2020) (14)
Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas (2021) (14)
Simian immunodeficiency virus infection alters chemokine networks in lung tissues of cynomolgus macaques: association with Pneumocystis carinii infection. (2010) (14)
A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination (2019) (14)
Stability Analysis of a Mathematical Model of the Immune Response with Delays (2007) (13)
The effects of different HIV type 1 strains on human thymic function. (2002) (12)
Identifying DNA splice sites using hypernetworks with artificial molecular evolution (2007) (12)
Multi-scale Models of Lung Fibrosis. (2020) (12)
CTL ACTION DURING HIV-1 IS DETERMINED VIA INTERACTIONS WITH MULTIPLE CELL TYPES (2005) (12)
Computational modeling of tuberculous meningitis reveals an important role for tumor necrosis factor-α. (2013) (11)
The Role of Dimensionality in Understanding Granuloma Formation (2018) (11)
Requirement for multiple activation signals by anti-inflammatory feedback in macrophages. (2006) (11)
A Framework for Network-Based Epidemiological Modeling of Tuberculosis Dynamics Using Synthetic Datasets (2020) (11)
Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination (2021) (10)
Modeling pathogen and host: in vitro, in vivo and in silico models of latent Mycobacterium tuberculosis infection (2005) (10)
Phase variation and host immunity against high molecular weight (HMW) adhesins shape population dynamics of nontypeable Haemophilus influenzae within human hosts. (2014) (10)
Virologic and Immunologic Events in Hilar Lymph Nodes During Simian Immunodeficiency Virus Infection: Development of Polarized Inflammation (2008) (10)
A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs (2020) (9)
Effectiveness of contact investigations for tuberculosis control in Arkansas. (2015) (9)
CaliPro: A Calibration Protocol That Utilizes Parameter Density Estimation to Explore Parameter Space and Calibrate Complex Biological Models (2020) (9)
The Multi-scale Immune Response to Pathogens: M. tuberculosis as an Example (2007) (9)
Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes (2018) (8)
PREDICTING EFFICACY OF PROTON PUMP INHIBITORS IN REGULATING GASTRIC ACID SECRETION (2004) (8)
Overcoming math anxiety: Malthus meets Koch (2005) (6)
To Sobol or not to Sobol? The effects of sampling schemes in systems biology applications. (2021) (6)
Data-Driven Model Validation Across Dimensions (2019) (6)
T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques (2022) (6)
Mathematical Models of Colonization and Persistence in Bacterial Infections (2000) (5)
JTB Editorial Malpractice: A Case Report. (2020) (5)
Advances in mathematical population dynamics - molecules, cells and man : proceedings of the 4th International Conference on Mathematical Population Dynamics (1998) (5)
MATHEMATICAL MODELS OF ANTI-TNF THERAPIES AND THEIR CORRELATION WITH TUBERCULOSIS (2012) (5)
A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes. (2022) (5)
A Diffusion Model for AIDS in a Closed, Heterosexual Population: Examining Rates of Infection (1996) (5)
Using Mathematics to Understand HIV (1996) (4)
A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes (2021) (4)
The importance of an inter-compartmental delay in a model for human gastric acid secretion (2003) (4)
Solution of the Asymmetric Mixing Problem (1998) (3)
Simian Immunodeficiency Virus Infection Potently Modulates Chemokine Networks and Immune Environments in Hilar Lymph Nodes of Cynomolgus Macaques (2013) (3)
Computational Modeling of Granuloma Formation in Tuberculosis Yields Insights into both Infection and Treatment (2014) (3)
Structural identifiability analysis of age-structured PDE epidemic models (2022) (3)
Mycobacterium tuberculosis Infection with Regulatory Mechanisms During Human A Model to Predict Cell-Mediated Immune (2001) (2)
Erratum: Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection (Journal of Immunology (2006) 176 (4296-4314)) (2006) (2)
Dynamics of multiple strains of infectious agents coupled by cross-immunity: A comparison of models (2002) (2)
Editorial overviewCurrent opinion in systems biology (2018) (2)
Structural identifiability analysis of PDEs: A case study in continuous age-structured epidemic models (2021) (1)
Temporal and Spatial Analyses of TB Granulomas to Predict Long-Term Outcomes (2020) (1)
Applying Optimization Algorithms to Tuberculosis Antibiotic Treatment Regimens (2017) (1)
Corrigendum: Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas (2021) (1)
T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques (2022) (1)
A Framework for Network-Based Epidemiological Modeling of Tuberculosis Dynamics Using Synthetic Datasets (2020) (1)
Erratum: Tuneable resolution as a systems biology approach for multi‐scale, multi‐compartment computational models (2014) (0)
Identifying host immune factors that drive epidemic dynamics in a multi-scale model of tuberculosis (2014) (0)
Concomitant immunity to M. tuberculosis infection (2022) (0)
Key dynamics from a simple model of HIV infection (1998) (0)
Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens (2022) (0)
Mathematical Modeling in Surgical Research (2001) (0)
91 – Mathematical Modeling (2001) (0)
Predicting T cell responses to multiple antigens in lymph nodes (VAC7P.990) (2014) (0)
Infection Mycobacterium tuberculosis during Antimicrobial Responses with Caseation Mediated - Early Host Immunity Control of Lesion Sterilization by Balancing Computational Modeling Predicts IL-10 (2014) (0)
Formation Dynamics in Tuberculosis Granuloma Receptor 1 α a Critical Role for TNF-Multiscale Computational Modeling Reveals (2011) (0)
Title: The effect of multiple genetic polymorphisms on antigen presentation 1 (2008) (0)
Erratum: (Journal of theoretical biology (1995) 176 (281-290)) (1995) (0)
Unraveling the role of fibrosis in the TB Granuloma (2019) (0)
Disease phenotypic and geospatial features vary across genetic lineages for Tuberculosis within Arkansas, 2010–2020 (2023) (0)
Strategies for Efficient Numerical Implementation of Hybrid Multi-scale Agent-Based Models to Describe Biological Systems (2014) (0)
PermeabilityDue to Drug Binding Kinetics and Reactivation among Anti-TNF Therapies Is Differential Risk of Tuberculosis (2012) (0)
Disclaimer (2006) (0)
Mathematics& AIDS: How MathematicsCoupledwith Experiment Revealedthe Natureof HIV Infection (1998) (0)
The dynamics of TNF signaling control tuberculosis granuloma formation (0)
Identifying key mechanisms in fibroblast disregulation using a systems biology approach. (IRM9P.727) (2014) (0)
Evaluation of tuberculosis control programs in low-burden settings (2014) (0)
CaliPro: A Calibration Protocol That Utilizes Parameter Density Estimation to Explore Parameter Space and Calibrate Complex Biological Models (2020) (0)
Mycobacterium tuberculosis to Response Presentation in the Human Immune Dendritic Cell Trafficking and Antigen (2004) (0)
Fifty years of JTB: past, present and future: a letter from the Editors-in-Chief. (2011) (0)
ack of good correlation of serum CC-chemokine evels with human immunodeficiency virus-1 disease tage and response to treatment (2004) (0)
Arginase Isoforms Expression of Nitric Oxide Synthase and Populations of Macrophage Subsets and Granulomas Are Delineated by Distinct Microenvironments in Tuberculous (2013) (0)
Cell Responses in Lymph Nodes Does Not Influence Priming of T tuberculosis Mycobacterium Inoculation Dose of (2013) (0)
Structural identifiability analysis of age-structured PDE epidemic models (2022) (0)
Priming within a Lymph Node Characterizing the Dynamics of CD4+ T Cell (2010) (0)
Binding Kinetics and Permeability among Anti-TNF Therapies Is Due to Drug Differential Risk of Tuberculosis Reactivation (2012) (0)
This information is current as Thymic Emigrants Circles as a Measure of Human Recent Reevaluation of T Cell Receptor Excision (2002) (0)
AIDS in the heterosexual population (1995) (0)
Using an agent-based model of mycobacterium tuberculosis infection to understand the roles of interleukin-10 during disease progression (2013) (0)
Infection Pathogenic Simian Immunodeficiency Virus Regulatory T Cells in Lymph Nodes during Chemokine and Cytokine Mediated Loss of (2008) (0)
Predicting the pattern of economics research: The case of the real business cycle theory (1996) (0)
Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation (2015) (0)

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