Denise Faustman

Q: What Schools Are Affiliated With Denise Faustman

Denise Faustman is affiliated with the following schools: University of Washington, Massachusetts General Hospital, Harvard University, George Washington University, Washington University in St. Louis, McGill University

Denise Faustman's AcademicInfluence.com Rankings

Denise Faustman

Biology

#5981

World Rank

#8593

Historical Rank

#1978

USA Rank

Immunology

#538

World Rank

#555

Historical Rank

#89

USA Rank

biology Degrees

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Biology

Denise Faustman's Degrees

Doctorate Medicine University of Washington
PhD Microbiology University of Washington

Why Is Denise Faustman Influential?

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According to Wikipedia, Denise Louise Faustman is an American physician and medical researcher. An associate professor of medicine at Harvard University and director of the Immunobiology Laboratory at Massachusetts General Hospital, her work specializes in diabetes mellitus type 1 and other autoimmune diseases. She has worked at Massachusetts General Hospital in Boston since 1985.

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Denise Faustman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

TNF receptor 2 pathway: drug target for autoimmune diseases (2010) (382)
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice (2003) (370)
Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. (1984) (219)
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. (1991) (216)
Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants. (1981) (203)
Reversal of established autoimmune diabetes by restoration of endogenous beta cell function. (2001) (182)
Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay (2012) (174)
Structural principles of tumor necrosis factor superfamily signaling (2018) (156)
Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. (1991) (147)
Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2 (2013) (144)
Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs (2017) (136)
Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes (2012) (130)
NOD Mice Are Defective in Proteasome Production and Activation of NF-κB (1999) (127)
Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism (2008) (122)
Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. (2002) (110)
Prevention of xenograft rejection by masking donor HLA class I antigens (1991) (105)
The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis (2005) (101)
Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations (2018) (100)
Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat. (1984) (100)
TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine (2013) (100)
Low levels of C‐peptide have clinical significance for established Type 1 diabetes (2015) (97)
TNFR2: A Novel Target for Cancer Immunotherapy. (2017) (89)
Treg activation defect in type 1 diabetes: correction with TNFR2 agonism (2016) (81)
Abnormal T-Lymphocyte Subsets in Type I Diabetes (1989) (75)
Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens (1980) (74)
Essential Role of Human Leukocyte Antigen-encoded Proteasome Subunits in NF-κB Activation and Prevention of Tumor Necrosis Factor-α-induced Apoptosis* (2000) (69)
NOD mice are defective in proteasome production and activation of NF-kappaB. (1999) (65)
Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity (2018) (62)
Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. (1993) (62)
Central role of defective apoptosis in autoimmunity. (2003) (60)
A role for transcription factor NF-κB in autoimmunity: possible interactions of genes, sex, and the immune response (2006) (55)
Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. (1997) (54)
Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. (2004) (53)
The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's-like disease (2013) (49)
Identification of premature ovarian failure patients with underlying autoimmunity. (2000) (47)
Novel splicing of the human MHC-encoded peptide transporter confers unique properties. (1999) (43)
Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells. (1982) (42)
Characterization of Mouse Spleen Cells by Subtractive Proteomics*S (2005) (42)
Role of defective apoptosis in type 1 diabetes and other autoimmune diseases. (2003) (42)
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome (2018) (41)
The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies (2009) (40)
Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis. (2018) (38)
BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism (2019) (38)
Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts. (1993) (37)
Diabetes and stem cell researchers turn to the lowly spleen. (2005) (36)
Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. (2000) (36)
Reversal of Sjögren’s-like syndrome in non-obese diabetic mice (2006) (35)
Reply to 'LMP2 expression and proteasome activity in NOD mice' (2000) (33)
Reduced expression of peptide‐loaded HLA class I molecules on multiple sclerosis lymphocytes (1995) (33)
Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders. (2010) (32)
Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse. (1994) (28)
Successful xenotransplantation of a diffusion-based biohybrid artificial pancreas: a study using canine, bovine, and porcine islets. (1992) (28)
A role for transcription factor NF-kappaB in autoimmunity: possible interactions of genes, sex, and the immune response. (2006) (27)
Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades (2013) (26)
TNF, TNF inducers, and TNFR2 agonists: A new path to type 1 diabetes treatment (2018) (26)
Implications of altered apoptosis in diabetes mellitus and autoimmune disease (2001) (24)
Reversal of type 1 diabetes in mice. (2007) (23)
Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group. (1997) (23)
A novel TNFR2 agonist antibody expands highly potent regulatory T cells (2020) (22)
Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. (2001) (22)
The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases. (2008) (21)
Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity (2008) (21)
Regenerative medicine: a radical reappraisal of the spleen. (2005) (21)
Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen. (2010) (20)
Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells. (1995) (19)
TNFR2 blockade alone or in combination with PD‐1 blockade shows therapeutic efficacy in murine cancer models (2020) (19)
Comment on Papers by Chong et al., Nishio et al., and Suri et al. on Diabetes Reversal in NOD Mice (2006) (19)
Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation. (2000) (17)
Treatment for salivary gland hypofunction at both initial and advanced stages of Sjögren-like disease: a comparative study of bone marrow therapy versus spleen cell therapy with a 1-year monitoring period. (2014) (17)
Demonstration of active tolerance in maintenance of established islet of Langerhans allografts. (1982) (17)
Impaired Processing and Presentation by MHC Class II Proteins in Human Diabetic Cells1 (2003) (17)
Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. (2002) (16)
Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans (2007) (16)
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer. (2021) (15)
Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression. (1994) (15)
On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function (2020) (15)
Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity (2020) (15)
Benefits of BCG‐induced metabolic switch from oxidative phosphorylation to aerobic glycolysis in autoimmune and nervous system diseases (2020) (15)
Treatment of Primary Sjgren Syndrome With Rituximab (2014) (15)
Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis. (1997) (14)
Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling (2015) (13)
Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls. (1997) (13)
Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes (2004) (13)
Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1 diabetes (2022) (12)
Expression of Proteasomal Immunosubunit ß1i Is Dysregulated in Inflammatory Infiltrates of Minor Salivary Glands in Sjögren’s Syndrome (2009) (12)
Occult CD45 T cell developmental defect in type 1 diabetes. (1993) (11)
Expression of major histocompatibility complex antigens in cultures of clonally derived human myoblasts (1993) (11)
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two (2016) (11)
BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes (2020) (11)
Gene Expression of Catalytic Proteasome Subunits and Resistance Toward Proteasome Inhibition of B Lymphocytes from Patients with Primary Sjögren Syndrome (2013) (10)
Strategies for circumventing transplant rejection: modification of cells, tissues and organs. (1995) (8)
The role of the proteasome in autoimmunity (2000) (8)
MHC class I and autoimmune diabetes. (1993) (8)
Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2. (1989) (8)
Novel Automated Blood Separations Validate Whole Cell Biomarkers (2011) (7)
The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy (2022) (7)
BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation (2021) (7)
Sex differences in autoimmunity (2004) (6)
Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants. (1985) (6)
Mechanisms of autoimmunity in type I diabetes (2004) (6)
A Role for NF-κB and the Proteasome in Autoimmunity (2000) (6)
Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. (2005) (6)
Immunotherapy on trial for new-onset type 1 diabetes. (2008) (6)
The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants (2014) (6)
TNFR1 and TNFR2 Expression and Induction on Human Treg Cells from Type 1 Diabetic Subjects (2015) (6)
Analysis of T lymphocyte subsets in all stages of diabetes. (1990) (6)
Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: A vital role for KDM2B. (2021) (6)
Faulty major histocompatibility complex class I function linked to autoimmune diabetes. (1992) (4)
BCG vaccine's off-target effects on allergic, inflammatory and autoimmune diseases: Worth another shot? (2021) (4)
Off‐target effects of bacillus Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2: implications for protection against severe COVID‐19 (2022) (4)
Family cell lines available for research--an endangered resource? (1997) (4)
Survival of heart allografts in nonimmunosuppressed murine recipients by pretreatment of the donor tissue with anti-Ia antibodies. (1982) (4)
Disposable No Longer: The Spleen Holds a Reservoir of Stem Cells (2014) (4)
Regenerative medicine: Stem cell research turns to the spleen. (2005) (4)
Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications (2021) (4)
Reduced expression of Tap 1 and Lmp2 antigen-processing genes in the NOD mouse due to a polymorphism in their shared bidirectional promoter (2009) (4)
Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. (2003) (4)
Reversal of Established Autoimmune Diabetes by in Situβ‐Cell Regeneration (2002) (3)
Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity (1994) (3)
The Potential of TNF Induction From BCG for the Treatment of Type 1 Diabetes (2018) (3)
People to watch (2006) (3)
TNF, BCG, and the Proteasome in Autoimmunity: An Overview of the Pathways & Results of a Phase I Study in Type 1 Diabetes (2014) (3)
Altered MHC class I expression: a role for transplantation and IDDM autoimmunity. (1995) (3)
Cells for repair: breakout session summary. (2002) (3)
Staying Current A role for transcription factor NF-B in autoimmunity : possible interactions of genes , sex , and the immune response (2006) (3)
EBV infection and anti-CD3 treatment for Type 1 diabetes: bad cop, good cop? (2013) (3)
Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization (2020) (3)
A role for NF-kappaB and the proteasome in autoimmunity. (2000) (3)
Signal Amplification in Highly Ordered Networks Is Driven by Geometry (2022) (2)
Bayesian analysis of case control polygenic etiology studies with missing data. (2001) (2)
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells (2022) (2)
Impact of Blood Sugar Control on Metabolites and Carbohydrate Metabolism in Type 1 Diabetes (2018) (2)
TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines (2020) (2)
Reversal of established autoimmune diabetes by in situ beta-cell regeneration. (2002) (2)
Historic and Emerging Applications of BCG in Prevention and Treatment of Disease (2015) (1)
Removal of Donor Human Leukocyte Antigen Class I Proteins With Papain: Translation for Possible Whole Organ Practices (2015) (1)
Abstract B77: TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models (2020) (1)
Early- Versus Late-Onset Type 1 Diabetes: Two Different Pathophysiological Subtypes with Implications for Therapy (2017) (1)
The Pancreas Secreting Insulin for Decades after Onset of Type I Diabetes — Implications for Care and Management (2015) (1)
Abstract B18: Novel treatment of cutaneous T cell lymphoma: Targeting TNFR2, an oncogene and marker of potent Tregs, with anti-TNFR2 antibodies (2018) (1)
Possible Transient Benefits of Epstein Barr Virus Infection in Three Subjects with Established Type 1 Diabetes (2014) (1)
Xenograft acceptance by masking donor antigens. (1992) (1)
The Politically Correct Xenograft (1995) (1)
Targeting TNFR2 to overcome acquired adaptive resistance to immune checkpoint blockade (2020) (1)
Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens. (1997) (1)
Opinion TNFR 2 : A Novel Target for Cancer Immunotherapy (2017) (1)
MON-179 Repeat BCG Vaccination Creates Lasting HbA1c Reductions in Adult Subjects with Longstanding Type 1 Diabetes by Correcting Immune-Metabolic Defects (2019) (1)
BCG Vaccine Health Impact Profile Diabetes Care Industry May 2020 (2020) (0)
First Genetic Associations Established for Sjögren's (2014) (0)
The reproductive impairment of the Hertwig's anemic mouse. (1973) (0)
Inactivation of highly potent regulatory T cells (Tregs) with TNFR2 antagonist antibodies as a novel cancer immunotherapy approach. (2015) (0)
Advances in Brief Development of Spontaneous Uterine Tumors in Low Molecular Mass Polypeptide-2 Knockout Mice 1 (2001) (0)
Abstract 514: Correlation of sTNFR2 elevation and disease progression in cutaneous T cell lymphomas (2022) (0)
SSF Clinical Practice Guidelines for Caries Prevention are Here ! (2016) (0)
Research: Complications Low levels of C-peptide have clinical significance for established Type 1 diabetes (2015) (0)
Targeting the TNFR2 oncogene on tumor cells and tregs of the tumor microenvironment via dominant TNFR2 antagonism. (2017) (0)
Chapter Twenty-Seven – Immunomodulation (2007) (0)
Abstract A50: Direct oncogene cancer killing and selective tumor Treg killing through the TNFR2 receptor via dominant antibody antagonists (2017) (0)
827-P: 2022 Update on the BCG Clinical Trial Programs in Advanced Type 1 Diabetes (2022) (0)
In summary: Islets and more: Pancreatic islet transplantation, medical intelligence unit, Editors: Robert Lanza and William Chick, R. G. Landes Company, Austin 1994 (1996) (0)
The Beginning of a New Era (1999) (0)
Methods and systems for sorting of blood cells (2006) (0)
Genetic Control of Interaction Between Class I and Class II Antigens in Murine Islet Rejection (1987) (0)
Comparison of class I ablated donor islet transplants: Permanent class I ablation may mean shorter survival (1996) (0)
Process for preparation of a transplantation of a cell or tissue (1993) (0)
NeutraSal ® is clinically proven to help restore the oral environment 2 FOR PATIENTS WITH SJÖGREN ’ S SYNDROME 90 % OF PATIENTS REPORTED IMPROVEMENT IN SWALLOWING (2017) (0)
Direct oncogene-targeted cancer killing and selective tumor Treg killing through the TNFR2 receptor via dominant antibody Antagonists (2017) (0)
1142-P: Update on BCG Clinical Trial Programs in Patients with Advanced Type 1 Diabetes (2021) (0)
Permanent Reversal of Diabetes in NOD Mice (2007) (0)
Genome and Hormones : Gender Differences in Physiology Selected Contribution : Association of gender-related LMP 2 inactivation with autoimmune pathogenesis (2001) (0)
Peptide Transporter Confers Unique Novel Splicing of the Human MHC-Encoded (1998) (0)
1268-P: Underlying T Cell Receptor Methylation Defects in Type 1 Diabetes Associated with Quantitative Defects (2022) (0)
CHAPTER 25 – IMMUNOMODULATION (2000) (0)
Abstract 1790: TNFR2-targeted elimination of Tregs and tumor-residing T cells in advanced cutaneous T cell lymphoma (2018) (0)
Antibodies for transplantation. (2000) (0)
Autoimmunity, Self-Tolerance, and MHC Class I Expression (1992) (0)
Cl in ic ian ’ s Corner Systemic Activity at Diagnosis of Sjögren ’ s : A Key Prognostic Marker (2015) (0)
TNFR2's Role in Influencing Tumor Tissue (2018) (0)
Phermone induced puberty in WB/Re females. (1975) (0)
Abstract 2136: Inhibiting cancer growth by targeting the TNFR2 oncogene with TNFR2 antagonistic antibodies (2017) (0)
Title: Historic and Emerging Applications of BCG in Prevention and Treatment of Disease (2015) (0)
Designer Tissues and Organs: Mouse to Man (1997) (0)
Abstract 962: Novel targeting of tumor-infiltrating TNFR2 Tregs: removing suppression with microenvironment-specific antibodies (2017) (0)
Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations (2018) (0)
Hormone deficiencies of the Hertwig's anemic mouse. (1975) (0)
Inflammatory Infiltrates of Minor Salivary Glands in Sjögren ' s Syndrome Expression of Proteasomal Immunosubunit ß 1 i Is Dysregulated in (2009) (0)
Human TNFR2 Exhibits Bi-Directional Control over Regulatory T Cells (2014) (0)
Royal academy of medicine in Ireland section of biomedical sciences (1992) (0)
On the periphery: Nature questions the role of women in science. (1999) (0)
CONCISE REPORT Reversal of Sjogren's-like syndrome in non-obese diabetic (2007) (0)
Book Review: In Summary: Islets and More (1996) (0)
the immune response autoimmunity: possible interactions of genes, sex, and B in κ A role for transcription factor NF- (2015) (0)
Removal of Donor HLA Class I Proteins with Papain: Translation for Possible Whole Organ Practices.: Abstract# C3039 (2014) (0)
NF-k B , Autoimmunity and Mycobacteria (2015) (0)
Type I autoimmune diabetes (1992) (0)
REVIEW Central role of defective apoptosis in autoimmunity (2003) (0)
Diabetes and stem cells according to : (2004) (0)
Chapter 27 – Immunomodulation (2014) (0)
When the Body Attacks Itself Autoimmune diseases afflict women much more frequently than men (0)
The Professionals ’ Resource on Sjögren ’ s Syndrome First Genetic Associations Established for Sjögren ’ s (2014) (0)
Repeat BCG Vaccination Creates Lasting Reductions of HbA1c in Subjects with Long-Term Type 1 Diabetes—Long-Term Clinical Trial Follow-up (2018) (0)
response possible interactions of genes , sex , and the immune B in autoimmunity : κ A role for transcription factor (2006) (0)
BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes (2022) (0)
The Diabetes Reversal Challenge The Unique Clinical Trial at the Faustman Lab (2009) (0)
Gender is important: lessons in autoimmunity. (1997) (0)
Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies (2023) (0)

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What Schools Are Affiliated With Denise Faustman?

Denise Faustman is affiliated with the following schools:

Denise Faustman's Academic­Influence.com Rankings