Dennis A. Dougherty
#43,709
Most Influential Person Now
American chemist
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Dennis A. Doughertychemistry Degrees
Chemistry
#616
World Rank
#1065
Historical Rank
#279
USA Rank
Organic Chemistry
#86
World Rank
#119
Historical Rank
#35
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Chemistry
Dennis A. Dougherty's Degrees
- Bachelors Chemistry University of Notre Dame
- PhD Chemistry University of California, Berkeley
Why Is Dennis A. Dougherty Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dennis A. Dougherty is the George Grant Hoag Professor of Chemistry at California Institute of Technology. His research applies physical organic chemistry to systems of biological importance. Dougherty utilizes a variety of approaches to further our understanding of the human brain, including the in vivo nonsense suppression methodology for incorporating unnatural amino acids into a variety of ion channels for structure-function studies.
Dennis A. Dougherty's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Cationminus signpi Interaction. (1997) (2690)
- Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp (1996) (2077)
- Cation-π interactions in structural biology (1999) (1507)
- Modern Physical Organic Chemistry (2005) (1248)
- The cation-π interaction. (2013) (792)
- From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. (1998) (478)
- Cation-pi interactions in structural biology. (1999) (475)
- A mechanism for ion selectivity in potassium channels: computational studies of cation-pi interactions. (1993) (465)
- Cys-loop receptors: new twists and turns (2004) (444)
- Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide. (1996) (433)
- A Gating Charge Transfer Center in Voltage Sensors (2010) (425)
- Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel (2005) (416)
- Cation-pi interactions in ligand recognition and catalysis. (2002) (362)
- Cation−π Interactions in Simple Aromatics: Electrostatics Provide a Predictive Tool (1996) (340)
- A Computational Study of Cation−π Interactions vs Salt Bridges in Aqueous Media: Implications for Protein Engineering (2000) (336)
- Nicotine Binding to Brain Receptors Requires a Strong Cation-π Interaction (2009) (335)
- Spin Control in Organic Molecules (1991) (314)
- Phenyl–Perfluorophenyl Stacking Interactions: A New Strategy for Supermolecule Construction (1997) (289)
- Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. (2002) (278)
- Unnatural amino acids as probes of protein structure and function. (2000) (215)
- Molecular recognition in aqueous media. New binding studies provide further insights into the cation-π interaction and related phenomena (1993) (189)
- Cation-pi interactions involving aromatic amino acids. (2007) (177)
- In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system. (1998) (165)
- Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery (2009) (161)
- "Hydrophobic" binding of water-soluble guests by high-symmetry, chiral hosts. An electron-rich receptor site with a general affinity for quaternary ammonium compounds and electron-deficient .pi. systems (1988) (153)
- A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors* (2005) (134)
- A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor. (2005) (133)
- Can lone pairs bind to a pi system? The water...hexafluorobenzene interaction. (1999) (127)
- Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines (2012) (126)
- Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels (2008) (125)
- Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel Implications for the Mechanism of Gating (1999) (119)
- Biomimetic catalysis of S_N2 reactions through cation-π interactions. The role of polarizability in catalysis (1992) (113)
- Unnatural amino acid mutagenesis in mapping ion channel function (2003) (106)
- Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor. (2005) (105)
- Cys-loop neuroreceptors: structure to the rescue? (2008) (97)
- Concerning the thermodynamics of molecular recognition in aqueous and organic media. Evidence for significant heat capacity effects (1990) (97)
- Molecular recognition in aqueous media: donor-acceptor and ion-dipole interactions produce tight binding for highly soluble guests (1988) (95)
- Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel. (2001) (95)
- THEORETICAL STUDIES OF THE SUPRAMOLECULAR SYNTHON BENZENE · · · HEXAFLUOROBENZENE (1997) (93)
- Strained rings as a source of unsaturation: polybenzvalene, a new soluble polyacetylene precursor (1988) (92)
- Unnatural Amino Acid Mutagenesis of the GABAA Receptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β2Tyr97 (2007) (92)
- An Engineered Tetrahymena tRNAGln for in Vivo Incorporation of Unnatural Amino Acids into Proteins by Nonsense Suppression* (1996) (91)
- Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine3 Receptor Revealed by Unnatural Amino Acid Mutagenesis (2004) (90)
- Investigating lipid composition effects on the mechanosensitive channel of large conductance (MscL) using molecular dynamics simulations. (2003) (89)
- Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor. (2012) (89)
- In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression. (2006) (87)
- Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K+ Channel* (1996) (86)
- A fluorophore attached to nicotinic acetylcholine receptor βM2 detects productive binding of agonist to the αδ site (2004) (86)
- A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block* (2007) (84)
- PROTOTYPES FOR THE POLARONIC FERROMAGNET. SYNTHESIS AND CHARACTERIZATION OF HIGH-SPIN ORGANIC POLYMERS (1994) (83)
- The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors (2015) (82)
- Tyrosine Decaging Leads to Substantial Membrane Trafficking during Modulation of an Inward Rectifier Potassium Channel (2001) (81)
- A Selective Receptor for Arginine Derivatives in Aqueous Media. Energetic Consequences of Salt Bridges That Are Highly Exposed to Water (1999) (80)
- Flash Decaging of Tyrosine Sidechains in an Ion Channel (1998) (77)
- Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis. (2004) (77)
- Site-specific, photochemical proteolysis applied to ion channels in vivo. (1997) (75)
- A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue (2008) (73)
- Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH (2010) (71)
- Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors. (2009) (70)
- Structure of hexaphenylethane and congeners as determined by empirical force field calculations (1977) (70)
- Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL). New gain of function mutations in the loop region. (2000) (70)
- Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge? (2003) (70)
- Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids (2009) (67)
- Cyclobutanediyls: a new class of localized biradicals. Synthesis and EPR spectroscopy (1988) (67)
- Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response (2012) (64)
- Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position (1996) (63)
- Effects of through-bond and through-space interactions on singlet-triplet energy gaps in localized biradicals (1983) (63)
- A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. (1996) (62)
- Synthesis and properties of diethyl 5,10-dihetera-5,10-dihydroindeno[2,1-a]indene-2,7-dicarboxylates (1993) (62)
- A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels (2006) (60)
- Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures. (2012) (60)
- Tight, oriented binding of an aliphatic guest by a new class of water-soluble molecules with hydrophobic binding sites. (1986) (60)
- Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists. (1996) (58)
- Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance. (2006) (58)
- Site-specific incorporation of unnatural amino acids into receptors expressed in Mammalian cells. (2003) (57)
- Probing the role of a conserved M1 proline residue in 5-hydroxytryptamine(3) receptor gating. (2000) (56)
- A computational study of nicotine conformations in the gas phase and in water. (2000) (55)
- Biomimetic Catalysis of an SN2 Reaction Resulting from a Novel Form of Transition-State Stabilization† (1990) (54)
- Evaluation of potential ferromagnetic coupling units: the bis(TMM) [bis(trimethylenemethane)] approach to high-spin organic molecules (1993) (52)
- Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes* (2011) (51)
- A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT3 Receptor (2008) (50)
- Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor. (2001) (50)
- Do High-Spin Topology Rules Apply to Charged Polyradicals? Theoretical and Experimental Evaluation of Pyridiniums as Magnetic Coupling Units (1996) (49)
- Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. (2007) (49)
- Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry (2003) (48)
- Cation-π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation. (2015) (47)
- Generation and Evaluation of a Large Mutational Library from the Escherichia coli Mechanosensitive Channel of Large Conductance, MscL (2003) (44)
- Novel magnetic properties of a doped organic polymer. A possible prototype for a polaronic ferromagnet (1991) (44)
- A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists (2011) (43)
- Expression and Circular Dichroism Studies of the Extracellular Domain of the α Subunit of the Nicotinic Acetylcholine Receptor* (1997) (43)
- GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study. (2012) (43)
- Neurobiology: Snails, synapses and smokers (2001) (41)
- Key binding interactions for memantine in the NMDA receptor. (2013) (41)
- Conformational analysis of tetraarylethanes (1978) (40)
- Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor. (2007) (40)
- A high-throughput screen for MscL channel activity and mutational phenotyping. (2001) (40)
- Ion-dipole effect as a force for molecular recognition in organic media (1988) (40)
- Concerning the Effects of Aromatic Ring Fluorination on the Cation−π Interaction and Other Molecular Recognition Phenomena in Aqueous Media (1998) (40)
- Physical organic chemistry on the brain. (2008) (40)
- Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor. (2012) (40)
- CIRCULAR DICHROISM STUDIES OF MOLECULAR RECOGNITION WITH CYCLOPHANE HOSTS IN AQUEOUS MEDIA (1995) (39)
- Functional Probes of Drug–Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provide a Fertile Testing Ground (2014) (39)
- An Intersubunit Hydrogen Bond in the Nicotinic Acetylcholine Receptor That Contributes to Channel Gating* (2008) (39)
- Calcium block of single sodium channels: role of a pore-lining aromatic residue. (2007) (38)
- Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor (2011) (37)
- In Vivo Incorporation of Non‐canonical Amino Acids by Using the Chemical Aminoacylation Strategy: A Broadly Applicable Mechanistic Tool (2014) (37)
- Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors (2019) (35)
- Non-kekulé molecules derived conceptually by heteroatom-for-carbon substitution in alternant hydrocarbons: M-Quinomethane and M-Naphthoquinomethane (1982) (35)
- Evidence for the Importance of Polarizability in Biomimetic Catalysis Involving Cyclophane Receptors. (1996) (34)
- Ondansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesis. (2012) (34)
- A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. (2004) (34)
- A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock. (2017) (33)
- On the role of Newman projections in conformational analysis. Evidence for nonalternating ground states in highly strained molecules (1978) (33)
- Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins. (1997) (32)
- A combination of empirical force field and extended Hueckel molecular orbital calculations as a computational approach to conformational analysis (1979) (32)
- Reconstitution of ion channels in agarose-supported silicon orifices. (2007) (32)
- Establishing an Ion Pair Interaction in the Homomeric ρ1 γ-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway* (2007) (31)
- Mapping disulfide connectivity using backbone ester hydrolysis. (1999) (30)
- Concerning the viability of 1,4,6,9-spiro[4.4]nonatetrayl as a reactive intermediate. New biradical-to-biradical rearrangements (1984) (30)
- Long-range coupling in an allosteric receptor revealed by mutant cycle analysis. (2009) (30)
- The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor. (2001) (30)
- Matrix-isolation decay kinetics of triplet cyclobutanediyls: observation of both arrhenius behavior and heavy-atom tunneling in C-C bond-forming reactions (1989) (30)
- 2,4-Dimethylene-1,3-cyclobutanediyl, the non-Kekule isomer of benzene. Synthesis, EPR, and electronic spectroscopy (1989) (29)
- Comparing and Contrasting Escherichia coliand Mycobacterium tuberculosis Mechanosensitive Channels (MscL) (2000) (28)
- Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor. (2011) (28)
- Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation. (2007) (27)
- Bond lengthening and through-bond interactions in p,p'-dibenzene and related molecules (1978) (27)
- Design and synthesis of a new class of hydrophobic binding sites (1986) (27)
- TETRAALKYLDISILANES AS MODELS FOR THE CONFORMATIONAL ANALYSIS OF TETRAALKYLDIPHOSPHINES (1978) (26)
- Structural requirements in the transmembrane domain of GLIC revealed by incorporation of noncanonical histidine analogs. (2014) (26)
- Ketamine inside neurons? (2015) (25)
- AN IMPROVED MODEL FOR ONE-DIMENSIONAL POLARONIC FERROMAGNETISM : ELECTROCHEMICALLY DOPED POLY(M-PHENYLENEFUCHSONE) (1998) (25)
- A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding. (2002) (25)
- M-QUINOMETHANE: SYNTHESIS OF A COVALENT-BIRADICALOID PAIR OF VALENCE TAUTOMERS (1979) (24)
- Caging proteins through unnatural amino acid mutagenesis. (2003) (24)
- Caged phosphoproteins. (2005) (24)
- Effects of substituents on the length of central C(sp3)–C(sp3) bond in anthracene photodimers and related molecules (1986) (24)
- Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis. (2006) (23)
- Band structures of polyfulvene and related polymers. A model for the effects of benzannelation on the band structures of polythiophene, polypyrrole, and polyfulvene (1988) (23)
- Conformational effects on high-spin organic molecules (1993) (23)
- Cyclobutane as a general ferromagnetic coupling unit. Design and synthesis of a new, hydrocarbon quintet (1989) (23)
- Student solutions manual to accompany Anslyn & Dougherty's Modern physical organic chemistry (2005) (23)
- THE CONFORMATION OF 1,1,2,2-TETRAPHENYLETHANE AND THE APPLICABILITY OF 3JHD TO CONFORMATIONAL ANALYSIS (1977) (23)
- Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2 (2012) (22)
- The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane. (2013) (22)
- Binding Interactions with the Complementary Subunit of Nicotinic Receptors* (2013) (22)
- 1,3-Diphenyl-1,3-cyclopentanediyl: A remarkably stable localized biradical (1988) (21)
- Multiple Tyrosine Residues Contribute to GABA Binding in the GABAC Receptor Binding Pocket (2011) (21)
- Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates. (2010) (21)
- Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel. (1998) (21)
- 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function (2008) (21)
- 2,4-Dimethylene-1,3-cyclobutadiyl (1985) (20)
- An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline (2013) (20)
- Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: evaluating suppression efficiency. (2007) (19)
- Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors (2014) (19)
- New insights into the therapeutic inhibition of voltage-gated sodium channels (2008) (19)
- Chemical Scale Studies of the Phe-Pro Conserved Motif in the Cys Loop of Cys Loop Receptors* (2010) (18)
- The Crystal Structure of a Potassium Channel- A New Era in the Chemistry of Biological Signaling. (1998) (18)
- Non-Kekule acenes. The dimethylenepolycyclobutadienes, a new class of (4n + 2) alternant hydrocarbons (1987) (17)
- Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor (2011) (17)
- Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process. (2017) (17)
- Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing (2018) (17)
- Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors (2014) (17)
- Preparation of translationally competent tRNA by direct chemical acylation. (2010) (16)
- Direct, ESR observation of the localized biradical 1,3-dimethyl-1,3-cyclobutadiyl (1984) (16)
- Photoactivation of an Acid‐Sensitive Ion Channel Associated with Vision and Pain (2016) (16)
- Long bonds and through-bond coupling (1976) (16)
- INCORPORATION OF ESTERS INTO PROTEINS : IMPROVED SYNTHESIS OF HYDROXYACYL TRNAS (1999) (16)
- Probing the Role of Backbone Hydrogen Bonding in a Critical β Sheet of the Extracellular Domain of a Cys‐Loop Receptor (2009) (15)
- A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way. (2012) (15)
- 2,3-Diazabicyclo[2.1.1]hex-2-ene. Synthesis and thermal decomposition (1981) (14)
- An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels (2009) (14)
- MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production. (2002) (14)
- New Designs for Very High Spin Hydrocarbons (1989) (14)
- Theoretical studies on 1,4,6,9-spiro[4.4]nonatetrayl, an organic tetraradical (1984) (13)
- 1-Oxo-5-hydroxytryptamine: a surprisingly potent agonist of the 5-HT3 (serotonin) receptor. (2007) (13)
- Cation-p Interactions Involving Aromatic Amino Acids 1 – 4 (2007) (13)
- Effects of CNN bond angle restriction in 2,3-diazabicyclo[2.1.1]hexane derivatives on nitrogen inversion barrier, ease of oxidation, and acidity (1991) (13)
- DNMR and molecular mechanics studies of the enantiomerization of long-chain (1,5)-naphthalenophanes (1985) (13)
- Allosteric activation of the 5-HT3AB receptor by mCPBG (2015) (13)
- Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl (2014) (13)
- Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression (2016) (13)
- Ferromagnetic and high spin molecular based materials in Dallas (1989) (12)
- Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor. (2019) (12)
- Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor (2014) (12)
- 2,4-dimethylenebicyclobutane: preparation, characterization, and relationship to the non-Kekulé isomer of benzene (1989) (12)
- A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor. (2008) (12)
- Photochemistry of 2,3-diazabicyclo[2.1.1]hex-2-ene. .beta. Carbon-carbon cleavage to a stereorandom triplet biradical (1982) (12)
- New designs for organic molecules and materials with novel magnetic properties (1990) (11)
- Rapid, multistep rearrangements of hydrocarbon triplet biradicals at 4 K. A possible example of hot molecule effects in frozen organic solvents (1988) (11)
- Diphenylbicyclo[2.1.0]pentane. A persistent hydrocarbon with a very weak carbon-carbon bond (1989) (10)
- A theoretical study of bis(cyclobutadienyl) and higher homologues: polycyclobutadiene as a novel organic metal? (1989) (10)
- Theoretical studies of the singlet and triplet potential energy surfaces of cyclobutanediyl (1989) (10)
- Confirming the revised C-terminal domain of the MscL crystal structure. (2008) (10)
- A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters. (2009) (10)
- Matrix Isolation EPR Spectroscopy of Biradicals (1990) (10)
- Structure of 9,9'-bitriptycyl (1978) (9)
- Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain Prevents GABA but Not Pentobarbital Activation (2010) (9)
- An improved method for determining bimolecular association constants from NMR titration experiments (1994) (9)
- New Views of Multi-Ion Channels (1998) (8)
- Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway. (2007) (8)
- Combination of Superexchange and Spin-Polarization Mechanisms Leads to a Novel Hydrocarbon Tetraradical with a High-Spin Ground State† (1994) (8)
- Symmetrical intermediates in C9H12 biradical rearrangements. Possible intervention of an organic tetraradical (1982) (8)
- Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor. (2012) (8)
- Concerning the relevance of ethane conformational analysis to acyclic aldol transition states (1982) (8)
- Cation-1 interactions in aromatics of biological and medicinal interest : Electrostatic potential surfaces as a useful qualitative guide ( aromatic amino acid / molecular recognition (2005) (8)
- JUMP ROPE ENANTIOMERIZATION OF 1,5-NAPHTHALENOPHANES AS A PROBE OF POLYMETHYLENE CHAIN CONFORMATIONAL DYNAMICS (1983) (7)
- Chemical activation as a probe of reaction mechanism. Synthesis and thermal decomposition of 2,3-diazabicyclo[2.1.1]hex-2-enes (1984) (7)
- Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors* (2015) (7)
- Phase-dependent stereochemistry and chemical activation in the thermal decomposition of 2,3-diazabicyclo[2.1.1]hexene (1982) (7)
- Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide. (2003) (7)
- Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands (2021) (7)
- Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, Mandelic acids, and their esters. (1978) (7)
- Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT3 and nACh Receptors. (2019) (7)
- Bicyclo[1.1.1]pentanone. Synthesis, thermal chemistry, and photochemistry (1984) (7)
- 3,4-Diazabenzvalene, the azoalkane precursor to tetrahedrane. Synthesis and reactivity. (1988) (7)
- Electronic spectroscopy of a non-Kekulé isomer of benzene, 2,4-dimethylene-1,3-cyclobutanediyl (1986) (7)
- Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors (2017) (7)
- Determining the conformations of organic macrocycles through a combination of Dale's rules, molecular mechanics, solid-state 13C NMR, and X-ray diffraction (1987) (7)
- Cation-p Interactions Involving Aromatic Amino Acids (2007) (6)
- An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors. (2015) (6)
- Physical Organic Chemistry on the Brain (2008) (6)
- A general strategy for visible-light decaging based on the quinone cis-alkenyl lock. (2019) (6)
- New Organic Polymers And Molecules With Very High Spin States (1993) (6)
- Internal rotation and pyramidal inversion in triacylphosphines (1979) (6)
- Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors (2015) (6)
- IS THE BRAIN READY FOR PHYSICAL ORGANIC CHEMISTRY (1998) (6)
- Attempted Synthesis of a Stable, Quintet, Tetraphenoxyl Tetraradical: Facile Rearrangement of a Substituted Bicyclobutane (1997) (6)
- Study of the A-ring conformation in 4,4-dimethyl-3-keto steroids (1979) (5)
- New high-spin π systems (1990) (5)
- CHEMICAL ACTIVATION AS A PROBE OF REACTION MECHANISM. SYNTHESIS AND THERMAL DECOMPOSITION OF 2,3‐DIAZABICYCLO(2.1.1)HEX‐2‐ENES (1984) (5)
- Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC. (2018) (5)
- “Hydrophobic” Binding of Water-Soluble Guests by High-Symmetry, Chiral Hosts. An Electron-Rich Receptor Site with a General Affinity for Quaternary Ammonium Compounds and Electron-Deficient π Systems. (1989) (5)
- Charge-transfer heptamethine dyes for NIR singlet oxygen generation. (2019) (5)
- From ab initio quantum mechanics to molecular neurobiology: A cation-p binding site in the nicotinic receptor (nicotinic acetylcholine receptorycation-p interactionyunnatural amino acids) (1998) (4)
- BICYCLO(1.1.1)PENTANONE. SYNTHESIS, THERMAL CHEMISTRY, AND PHOTOCHEMISTRY (1985) (4)
- Investigating the Binding Interactions of NS6740, a Silent Agonist of the Nicotinic Receptor. (2019) (4)
- Experimental and Computational Studies of Cation-π Interactions in Natural and Synthetic Receptors. Benzene as a Pseudoanion (1994) (4)
- A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors (2018) (4)
- Tight, Oriented Binding of an Aliphatic Guest by a New Class of Water‐Soluble Molecules with Hydrophobic Binding Sites. (1987) (4)
- THEORETICAL STUDIES ON 1,4,6,9-SPIRO(4.4)NONATETRAYL, AN ORGANIC TETRARADICAL (1984) (4)
- The 5-HT 3 AB Receptor Shows an A 3 B 2 Stoichiometry at the Plasma Membrane (2013) (4)
- Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids (2022) (3)
- Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients (2020) (3)
- Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. (2017) (3)
- Approaches to Magnetic Organic Materials (1991) (3)
- Structure of a Cyclophane Host Molecule (1993) (3)
- Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors. (2012) (3)
- Subtype-Specific Mechanisms for Functional Interaction between a 6 b 4 * Nicotinic Acetylcholine Receptors and P 2 X Receptors s (2014) (3)
- In Vivo Studies of Receptors and Ion Channels with Unnatural Amino Acids (2009) (3)
- Evaluation of Potential Ferromagnetic Coupling Units: The Bis(TMM) Approach to High-Spin Organic Molecules. (2010) (3)
- PROGRESS TOWARD AN ALL-ORGANIC MAGNET.: HIGH SPIN MOLECULES AND POLYMERS (1993) (2)
- Electronic Spectroscopy of a Non‐Kekulé Isomer of Benzene, 2,4‐Dimethylene‐1,3‐cyclobutanediyl (1986) (2)
- Binding Interactions of NS6740, a Silent Agonist of the α7 Nicotinic Acetylcholine Receptor (2019) (2)
- Mechanism of thermal rearrangement of the spiro bicyclo[2.1.0]-pentane-5,2'-methylenecyclopropanes to 6- and 7- methylenebicyclo[3.2.0]hept-1-enes. (1980) (2)
- Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor. (2022) (2)
- Proline Residues Contribute to Efficient GABAp Receptor Function. (2020) (2)
- Imaging Novel Ruthenium bipyridine-based Nanophotoswitches in Retina (2015) (1)
- Investigation of Dopamine Receptor Structure and Function by Structure Prediction and Unnatural Amino Acid Mutagenesis (2012) (1)
- Nicotinic Drugs in the Endoplasmic Reticulum: Beginning the Inside-out Pathway of Addiction and Therapy (2019) (1)
- Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem (2019) (1)
- Thinking Outside the Box: Residues that Shape the Agonist Binding Site of Nicotinic Acetylcholine Receptors (2010) (1)
- STRUCTURE OF 9,9′‐BITRIPTYCYL (2002) (1)
- Conformation and electronic structure of poly(3,4-diisopropylidenecyclobutene), a cross-conjugated conductive polymer (1987) (1)
- Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues (2022) (1)
- Reconstitution and in-vitro activation of the prokaryotic pentameric ligand-gated ion channel ELIC (2015) (1)
- Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABAA Receptor. (2020) (1)
- Anthracene Photodimers and Related Molecules (1986) (1)
- Synthesis and Properties of Diethyl 5,10-Dihetera-5,10-dihydroindeno(2, 1-a)indene-2,7-dicarboxylates. (2010) (1)
- Physical organic chemistry in the brain (1997) (1)
- Matrix‐Isolation Decay Kinetics of Triplet Cyclobutanediyls. Observation of Both Arrhenius Behavior and Heavy‐Atom Tunneling in C‐C Bond‐Forming Reactions. (1989) (1)
- Stereochemical issues in studies of ion channel proteins. (1998) (1)
- Cation-π Interactions: Computational Analyses of the Aromatic Box Motif and the Fluorination Strategy for Experimental Evaluation of Cys-Loop Receptors and Related Structures (2016) (0)
- Pos Cell-based Single-molecule Detection of a Fluorescent Unnatural Amino Acid Incorporated into the Nicotinic Receptor (2008) (0)
- Cyclobutane as a General Ferromagnetic Coupling Unit. Design and Synthesis of a New, Hydrocarbon Quintet. (1990) (0)
- Do High-Spin Topology Rules Apply to Charged Polyradicals? Theoretical and Experimental Evaluation of Pyridiniums as Magnetic Coupling Units. (2010) (0)
- Cation-m Interactions inChemistry andBiology: ANewViewofBenzene, Phe,Tyr, andTrp (2016) (0)
- Biochemical and Functional Characterization of a Novel Prokaryote Ligand-Gated Ion Channel CLIC (2014) (0)
- Ion Channels in Xenopus Oocyte Expression System (0)
- Two neuronal nicotinic acetylcholine receptors, α4β4 and α7, show differential agonist binding modes. (2011) (0)
- Differential Functional Requirements at the Binding Site Between Serotonin and the Partial Agonist M-Chlorophenylbiguanide in Serotonin 3A Receptors (2012) (0)
- Non-canonical proline analogs reveal mechanistic trends among GLIC and other ligand-gated ion channels (2016) (0)
- Chapter 4: Longrange Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis Reproduced with Permission From (0)
- Some applications of the empirical force field method to stereochemistry (2010) (0)
- Division of Organic Chemistry (1991) (0)
- CONCERNING THE VIABILITY OF 1,4,6,9-SPIRO(4.4)NONATETRAYL AS A REACTIVE INTERMEDIATE. NEW BIRADICAL-TO-BIRADICAL REARRANGEMENTS (1984) (0)
- Design and Synthesis of a New Class of Hydrophobic Binding Sites. (1986) (0)
- A Theoretical Study of Bi(cyclobutadienyl) (I) and Higher Homologues (II). Polycyclobutadiene as a Novel Organic Metal (1989) (0)
- Conformational Entropic Maps of Functional Coupling Domains in GPCR Activation: A Case Study of β2 Adrenergic Receptor (2013) (0)
- The Crystal Structure of a Potassium Channel — A New Era in the Chemistry of Biological Signaling (1998) (0)
- J. D. Roberts Special Issue (2018) (0)
- Twenty questions: Highlighting the pitfalls and possibilities of drug research (2004) (0)
- Contents page + Editorial Board (2004) (0)
- A Functional Probe of Ligand Binding and Agonist Efficacy in Ionotropic Glutamate Receptors (2010) (0)
- Progress in Development of Improved Ion-Channel Biosensors (2008) (0)
- Ion Channel Dynamics: Physical monitoring of the gating event using electrophysiology and time-resolved spectroscopy (2014) (0)
- 2,4-Dimethylenebicyclobutane: Preparation, Characterization, and Relationship to the Non-Kekule Isomer of Benzene. (1989) (0)
- Determining the Conformations of Organic Macrocycles (I) Through a Combination of Dale′s Rules, Molecular Mechanics, Solid-State 13C NMR, and X-Ray Diffraction (1987) (0)
- Effects of Substituents on the Length of Central C(sp3) ‐ C(sp3) Bond in Anthracene Photodimers and Related Molecules. (1986) (0)
- Function of nAChRs Containing Alpha5 Subunits (2012) (0)
- THERMOLABILE HYDROCARBONS. XII. CONFORMATIONAL ANALYSIS OF 1,2-DIALKYL-1,2-DIARYLETHANES (1980) (0)
- Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane (2022) (0)
- Conducting and Magnetic Polymers. (1981) (0)
- Visible-Light Absorbing, Photolabile, Quinone-Based Protecting Groups for Alcohols and Amines (2016) (0)
- Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor (2016) (0)
- BIOL 76-Investigations of agonist-receptor cation-pi interactions in cys-loop ligand gated ion channels (2008) (0)
- 5-HT3 Receptor MX Helix Contributes to Receptor Function (2022) (0)
- Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors (2014) (0)
- Characterizing the Architecture of Nicotinic Receptors with Quantum Dot-Based Fluorescence Microscopy (2009) (0)
- Prokaryotic Cys-Loop Receptor Homologs as Mechanistic Models for Channel Function (2014) (0)
- Conducting and magnetic polymers. Final technical report, 1 January 1991-31 October 1995 (1995) (0)
- 1,3-Diphenyl-1,3-cyclopentanediyl (IV), a Remarkably Stable Localized Biradical. (1989) (0)
- Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids (2023) (0)
- Photorelease of biologically relevant molecules using near-IR light (2016) (0)
- New Synthetic Receptor Derived from Bridged Anthracenes (1991) (0)
- Improved Ion-Channel Biosensors (2004) (0)
- Spotlights on our sister journals: Angew. Chem. Int. Ed. 28/2016. (2016) (0)
- Probing Molecular Interactions in Erwinia Ligand-Gated Ion Channel (ELIC) (2016) (0)
- The Nicotinic Pharmacophore - Binding Interactions in the Neuronal α4β2 Receptor (2010) (0)
- PHOTOCHEMISTRY OF 2,3-DIAZABICYCLO(2.1.1)HEX-2-ENE. β CARBON-CARBON CLEAVAGE TO A STEREORANDOM TRIPLET BIRADICAL (1982) (0)
- Combination of Superexchange and Spin-Polarization Mechanisms Leads to a Novel Hydrocarbon Tetraradical (VIII) with a High-Spin Ground State. (1994) (0)
- Polymer stereochemistry: an opportunity and a challenge on Titan. (2001) (0)
- Computational studies of cation-π interactions and applications to neuroscience (2015) (0)
- Human α6β4 nicotinic acetylcholine receptor: heterologous expression and agonist behavior provide insights into the immediate binding site. (2023) (0)
- Cys‐Loop Neuroreceptors: Structure to the Rescue? (2008) (0)
- Disulfide crosslinking in the alpha and gamma subunits of the nicotinic acetylcholine receptor (2000) (0)
- PHASE-DEPENDENT STEREOCHEMISTRY AND CHEMICAL ACTIVATION IN THE THERMAL DECOMPOSITION OF 2,3-DIAZABICYCLO(2.1.1)HEXENE (1982) (0)
- Cyclophane Hosts: Binding of Lipophilic and Cationic Guests (1997) (0)
- Rapid, Multistep Rearrangements of Hydrocarbon Triplet Biradicals at 4 K. A Possible Example of Hot Molecule Effects in Frozen Organic Solvents. (1988) (0)
- Single-Channel Recording of Muscle and Neuronal Nicotinic Acetylcholine Receptors: Implications for Allosteric Transitions (2010) (0)
- Probing binding interactions of agonists at a nicotinic acetylcholine receptor subtype important to addiction and Parkinson's disease (2016) (0)
- Probing the Binding Sites and Transmembrane Prolines of GPCRs Using Unnatural Amino Acids (2010) (0)
- Organic Cations in Molecular Recognition and Molecular Magnetism (1996) (0)
- Fluorescence Screens for Identifying Central Nervous System-Acting Drug-Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics. (2022) (0)
- The Pros of nACh and 5-HT 3 Receptors (2018) (0)
- Nicotinic Acetylcholine Receptor Subtypes Dorsal Root Ganglion Neurons Express Multiple (2015) (0)
- Alpha6∗ Nicotinic Receptors and P2X Receptors: Physical and Functional Interactions (2012) (0)
- 2,4-Dimethylene-1,3-cyclobutanediyl (VII), the Non-Kekule Isomer of Benzene. Synthesis, EPR, and Electronic Spectroscopy. (1989) (0)
- Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes (2014) (0)
- Natural and non-canonical mutagenesis studies of receptor gating in 5-HT3A receptors (2016) (0)
- Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands (2022) (0)
- Cyclobutanediyls: A New Class of Localized Biradicals. Synthesis and EPR Spectroscopy. (1988) (0)
- Conformational Effects on High‐Spin Organic Molecules (1994) (0)
- Evaluation of potential ferromagnetic coupling units: the bis(TMM) [bis(trimethylenemethane)] approach to high-spin organic molecules. [Erratum to document cited in CA118(23):233363r] (1993) (0)
- The cation-π interaction: From structural biology to neuroreceptor binding sites (2002) (0)
- F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel (2010) (0)
- Flash Decaging of Tyrosine Neurotechnique Sidechains in an Ion Channel (1998) (0)
- Insights into Gating Motions of GLIC via Perturbation of Critical Prolines with Non-Canonical Amino Acid Probes (2016) (0)
- Diphenylbicyclo(2.1.0)pentane. A Persistent Hydrocarbon with a Very Weak C-C Bond. (1989) (0)
- Microwave spectrum and structure of bicyclo /1.1.1/ pentanone and comparison with several theoretical structures (1986) (0)
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