Diane Kelly
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Professor of microbiology
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Biology
Diane Kelly 's Degrees
- PhD Microbiology Stanford University
- Masters Microbiology Stanford University
- Bachelors Biology University of California, Berkeley
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Why Is Diane Kelly Influential?
(Suggest an Edit or Addition)According to Wikipedia, Diane Kelly is a Professor of Microbiology, Institute of Life Science, Swansea University Medical School and Fellow of the Learned Society of Wales. Career After undergraduate study in London, she undertook a PhD at Swansea University followed by postdoctoral work at the University of Sheffield, researching microbial cytochromes P450. After a position at Aberystwyth University she returned to Swansea University Medical School as Reader and then Professor. She continues to research sterol metabolism and microbial cytochromes P450 as targets for antifungal agents in medicine and agriculture, and has authored over fifty papers on these subjects. She is a member of the BBSRC pool of experts and Natural Products board member. In 2017 she was elected a Fellow of the Learned Society of Wales. She has also chaired Swansea University's Athena SWAN committee, the medical school's Athena SWAN and Equality and Diversity committees, and is a regular member/chair of UK Athena SWAN assessment panels.
Diane Kelly 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Functional profiling of the Saccharomyces cerevisiae genome (2002) (4225)
- Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains (1998) (345)
- Resistance to fluconazole and cross‐resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6‐desaturation (1997) (342)
- Mode of Action and Resistance to Azole Antifungals Associated with the Formation of 14α-Methylergosta-8,24(28)-dien-3β,6α-diol (1995) (255)
- The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity* (1997) (208)
- Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. (2015) (178)
- Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? (2013) (174)
- Systematic analysis of yeast strains with possible defects in lipid metabolism (1999) (163)
- Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents* (1997) (147)
- Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients (1996) (144)
- Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans (2010) (137)
- A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14α-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B (2010) (136)
- The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity (2000) (134)
- The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM, and CYP51) (*) (1996) (126)
- The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2)* (2002) (123)
- Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. (1999) (116)
- The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity. (1999) (115)
- Resistance to antifungals that target CYP51 (2014) (115)
- Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens (2012) (113)
- The 2008 update of the Aspergillus nidulans genome annotation: a community effort. (2009) (111)
- Impact of Recently Emerged Sterol 14α-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity (2011) (106)
- The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme (2014) (105)
- Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51) (2010) (100)
- Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B (2012) (94)
- Molecular aspects of azole antifungal action and resistance. (1999) (90)
- Molecular genetic analysis of azole antifungal mode of action. (1993) (89)
- Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B (2010) (86)
- Biodiversity of the P450 catalytic cycle: yeast cytochrome b 5/NADH cytochrome b 5 reductase complex efficiently drives the entire sterol 14‐demethylation (CYP51) reaction (1999) (84)
- Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola (2011) (82)
- The CYPome (Cytochrome P450 complement) of Aspergillus nidulans. (2009) (79)
- Heterologous Expression of Mutated Eburicol 14α-Demethylase (CYP51) Proteins of Mycosphaerella graminicola To Assess Effects on Azole Fungicide Sensitivity and Intrinsic Protein Function (2010) (78)
- Characteristics of the heterologously expressed human lanosterol 14α‐demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents (1999) (73)
- A Novel Sterol 14α-Demethylase/Ferredoxin Fusion Protein (MCCYP51FX) from Methylococcus capsulatusRepresents a New Class of the Cytochrome P450 Superfamily* (2002) (73)
- Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol. (1995) (71)
- Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol Δ 22‐desaturase (1995) (71)
- The biodiversity of microbial cytochromes P450. (2003) (70)
- Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals (2010) (67)
- Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance (2014) (66)
- A sterol biosynthetic pathway in Mycobacterium (1998) (65)
- Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-α-Demethylase (2012) (65)
- Microalgae biochar-derived carbon dots and their application in heavy metal sensing in aqueous systems. (2019) (60)
- Molecular diversity of sterol 14α‐demethylase substrates in plants, fungi and humans (1998) (59)
- Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis. (2000) (58)
- Generation of a complete, soluble, and catalytically active sterol 14 alpha-demethylase-reductase complex. (1999) (58)
- Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2 (2012) (57)
- The N-Terminal Membrane Domain of Yeast NADPH-Cytochrome P450 (CYP) Oxidoreductase Is Not Required for Catalytic Activity in Sterol Biosynthesis or in Reconstitution of CYP Activity* (1998) (56)
- Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. (2007) (54)
- In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection (2017) (50)
- Genome-Wide Generation of Yeast Gene Deletion Strains (2001) (50)
- Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents. (2000) (49)
- The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme (2016) (44)
- Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans. (2004) (44)
- Activities and kinetic mechanisms of native and soluble NADPH-cytochrome P450 reductase. (2001) (44)
- Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14α-Demethylase at the Homologous Locus (2008) (42)
- Glyphosate is an inhibitor of plant cytochrome P450: functional expression of Thlaspi arvensae cytochrome P45071B1/reductase fusion protein in Escherichia coli. (1998) (42)
- Purification, Reconstitution, and Inhibition of Cytochrome P-450 Sterol Δ22-Desaturase from the Pathogenic Fungus Candida glabrata (1999) (41)
- Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B (2010) (39)
- Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14α-Demethylase (CYP51) (2014) (38)
- Sterol 22‐desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism (1997) (38)
- An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance. (2001) (38)
- The Diversity and Importance of Microbial Cytochromes P450 (2005) (37)
- CYP56 (Dit2p) in Candida albicans: Characterization and Investigation of Its Role in Growth and Antifungal Drug Susceptibility (2008) (35)
- Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis (2003) (35)
- Metabolic activation of cytochrome P-450/P-448 in the yeast Saccharomyces cerevisiae. (1983) (35)
- In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus (2015) (34)
- Plant sterol 14 alpha-demethylase affinity for azole fungicides. (2001) (33)
- Metabolism of organochlorine pesticides: the role of human cytochrome P450 3A4. (1996) (32)
- Differential inhibition of Candida albicans CYP51 with azole antifungal stereoisomers. (1997) (32)
- Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) (2015) (31)
- Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma (2019) (31)
- Expression, purification and use of the soluble domain of Lactobacillus paracasei beta-fructosidase to optimise production of bioethanol from grass fructans. (2010) (26)
- Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family. (2002) (26)
- Benzo(a)pyrene hydroxylase activity in yeast is mediated by P450 other than sterol 14 alpha-demethylase. (1993) (25)
- Cytochrome P450 3A4 mediated metabolism of 2,4-dichlorophenol. (1997) (25)
- S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole (2012) (25)
- Molecular studies on azole sensitivity in fungi (1993) (24)
- The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51). (1996) (24)
- Investigation of the role of sterol delta 8-->7-isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph. (1994) (23)
- The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae. (1991) (23)
- The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions (2019) (22)
- Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. (2003) (21)
- Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole. (2003) (21)
- Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14α‐demethylase (CYP51; P45014DM) (1998) (21)
- Rewiring yeast for drug synthesis (2003) (21)
- Interaction between yeast cytochrome P-450 and chemical carcinogens. (1985) (20)
- Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae (2008) (20)
- Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363. (1997) (19)
- The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51 (2017) (19)
- Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock (2014) (19)
- NADPH Cytochrome P-450 Oxidoreductase and Susceptibility to Ketoconazole (1998) (18)
- Engineering of heterologous cytochrome P450 in Acinetobacter sp.: application for pollutant degradation. (2000) (18)
- Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5 (2001) (18)
- Cytochrome P450 biodiversity and biotechnology. (2006) (17)
- In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection (2018) (17)
- Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism. (2002) (17)
- Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy (2013) (16)
- Multivariate analysis of biochar-derived carbonaceous nanomaterials for detection of heavy metal ions in aqueous systems. (2019) (16)
- Use of 70% alcohol for the routine removal of microbial hard surface bioburden in life science cleanrooms. (2014) (16)
- Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. (2011) (15)
- Comparative study of the characteristics and fluorescent properties of three different biochar derived‑carbonaceous nanomaterials for bioimaging and heavy metal ions sensing (2019) (15)
- Expression and Characterization of CYP51, the Ancient Sterol 14-demethylase Activity for Cytochromes P450 (CYP), in the White-Rot Fungus Phanerochaete chrysosporium (2008) (15)
- Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases (2017) (14)
- Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli (1997) (14)
- Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. (2018) (13)
- Human sterol 14alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5). (2001) (13)
- Metabolism of the herbicide chlortoluron by human cytochrome P450 3A4. (1995) (13)
- Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept (2014) (12)
- Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiae WH12 gene. (1988) (12)
- Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase (2015) (12)
- Metabolic Control Analysis and Engineering of the Yeast Sterol Biosynthetic Pathway (2004) (11)
- Studies on azole-induced cell death in Saccharomyces cerevisiae. (1994) (11)
- Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa (2016) (11)
- Lanosterol to Ergosterol — Enzymology, Inhibition and Genetics (1990) (11)
- Widespread distribution of resistance to triazole fungicides in Brazilian populations of the wheat blast pathogen (2020) (11)
- Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14 alpha-demethylase (CYP51; P450(14DM)). (1998) (10)
- The cytochrome P450 complement (CYPome) of Mycosphaerella graminicola (2013) (10)
- Sterol 14α-Demethylase: Target of the Azole Antifungal Agents (1992) (10)
- Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans (2020) (9)
- An algorithm for rapid computational construction of metabolic networks: A cholesterol biosynthesis example (2013) (9)
- Human cytochrome P450 3A4 is involved in the biotransformation of the herbicide 2,4-dichlorophenoxyacetic acid. (1996) (8)
- Studies on the Toxicity of Analogues of Dapsone In‐vitro Using Rat, Human and Heterologously Expressed Metabolizing Systems † (1996) (8)
- Involvement of Human Cytochrome P450 3A4 in the metabolism of Vamidothion (1996) (6)
- Degradation of a leather-dye by the combination of depolymerised wood-chip biochar adsorption and solid-state fermentation with Trametes villosa SCS-10 (2020) (6)
- Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens. (2019) (5)
- Role of cytochrome P450 in tulip bulb probed by substrate-binding studies (1992) (5)
- Differences in the cytochrome P-450 enzymes of sterol C-14 demethylase mutants of Saccharomyces cerevisiae (2004) (4)
- NanoRefinery of carbonaceous nanomaterials: Complementing dairy manure gasification and their applications in cellular imaging and heavy metal sensing. (2019) (4)
- Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase (2017) (4)
- Progesterone biotransformation by human P4503A4 in yeast (2004) (4)
- Prothioconazole binds to Mycosphaerella graminicola CYP51 by a different mechanism compared to other azole antifungals (2010) (4)
- An old activity in the P450 superfamily (CYP51) and a new story of drugs and resistance (2001) (3)
- Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals (1999) (3)
- P450s in Microbial Sterol Biosynthesis and Drug Targets (2008) (2)
- Role of Sterol Δ5(6) Desaturase in Azole Antifungal Mode of Action and Resistance (1996) (2)
- Analysis and exploitation of cytochrome P-450 in yeast. (1988) (2)
- Studies on yeast host strains for heterologous P450 expression (2004) (2)
- P 450 s in Microbial Sterol Biosynthesis and Drug Targets (2008) (1)
- Identification , characterization and azole-binding properties of 1 Mycobacterium smegmatis CYP 164 A 2 , a homolog of ML 2088 , 2 the sole cytochrome P 450 gene of Mycobacterium leprae 3 4 (2009) (0)
- Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis (2009) (0)
- In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole, (2018) (0)
- azole resistance mechanisms in clinical isolates of Candida albicans and Cryptococcus neoformans from intensive care patients (2001) (0)
- A Study of the Genotoxicity of DAB, CDA, BZD and DAT in the Strain JD1 of Saccharomyces cerevisiae (1985) (0)
- Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept (2014) (0)
- Azole sterol biosynthesis inhibitors as anti mycobacterial agents (2001) (0)
- Manipulation of P450 in Acinetobacter and application to pollutant degradation (2001) (0)
- Functional characterisation of Mycosphaerella graminicola sterol 14α-demethylase variants resistant to azole fungicides. (2011) (0)
- Probing the activity of agrochemicals against plant and fungal CYP51 (2001) (0)
- Complementation of Saccharomyces cerevisiae ERG11/CYP51 regulated mutant and screening the azole sensitivity of Aspergillus fumigatus CYP51A and B. (2010) (0)
- Evolution of cytochrome P450 sterol 22-desaturase in yeast and other microbial eukaryotes (2007) (0)
- demethylase) doxycycline regulated mutant and screening the azole- 4 sensitivity of Aspergillus fumigatus isoenzymes CYP51A and B 5 6 (2010) (0)
- Candida glabrata 22-Desaturase from the Pathogenic Fungus Δ of Cytochrome P-450 Sterol Purification, Reconstitution, and Inhibition (2013) (0)
- Title 1 In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole , 2 PC 1244 on Aspergillus fumigatus Infection 3 4 (2018) (0)
- inhaled azole , 2 PC 945 , on Aspergillus fumigatus infection 3 4 5 (2017) (0)
- NANOMATERIALS FOR DETECTION OF HEAVY METAL IONS IN AQUEOUS (2019) (0)
- Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids (2022) (0)
- Azole Affinity of Sterol 14 (cid:1) -Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens (2013) (0)
- Heterologous CYP51 expression to probe altered interactions with azole inhibitors (2001) (0)
- Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase (2017) (0)
- Yeast cytochrome P450 reductase; expression of a soluble and full-length form, kinetic mechanisms and crystallisation (2001) (0)
- Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae (cid:1) (2009) (0)
- Analysis of the benzo[a]pyrene hydroxylase P-450 of Saccharomyces cerevisiae (1991) (0)
- Identification and characterisation of four azole-resistant erg3 mutants of 2 (2010) (0)
- Classification: Biological Sciences, Biochemistry 1 Functional Importance for Developmental Regulation of Sterol Biosynthesis in 2 Acanthamoeba castellanii 3 (2018) (0)
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