Diarmaid Hughes
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Diarmaid Hugheschemistry Degrees
Chemistry
#4891
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#5985
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Organic Chemistry
#811
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#911
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Chemistry
Diarmaid Hughes's Degrees
- Bachelors Chemistry University of Oxford
- PhD Chemistry Stanford University
Why Is Diarmaid Hughes Influential?
(Suggest an Edit or Addition)Diarmaid Hughes's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Antibiotic resistance and its cost: is it possible to reverse resistance? (2010) (1843)
- Selection of Resistant Bacteria at Very Low Antibiotic Concentrations (2011) (1267)
- Microbiological effects of sublethal levels of antibiotics (2014) (1134)
- Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. (2000) (442)
- Mechanisms and consequences of bacterial resistance to antimicrobial peptides. (2016) (427)
- Persistence of antibiotic resistance in bacterial populations. (2011) (365)
- Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary Tract Infections (2003) (351)
- Virulence of antibiotic-resistant Salmonella typhimurium. (1998) (343)
- Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness (2009) (298)
- Evolution of antibiotic resistance at non-lethal drug concentrations. (2012) (287)
- Biological cost and compensatory evolution in fusidic acid‐resistant Staphylococcus aureus (2001) (265)
- Gene amplification and adaptive evolution in bacteria. (2009) (249)
- Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms (2015) (190)
- Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes (2005) (163)
- Muller's ratchet decreases fitness of a DNA-based microbe. (1996) (155)
- Biological Cost of Single and Multiple Norfloxacin Resistance Mutations in Escherichia coli Implicated in Urinary Tract Infections (2005) (154)
- Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium (1999) (151)
- Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. (2000) (145)
- Evolutionary Trajectories to Antibiotic Resistance. (2017) (145)
- Selection of resistance at lethal and non-lethal antibiotic concentrations. (2012) (142)
- Fitness‐compensatory mutations in rifampicin‐resistant RNA polymerase (2012) (136)
- Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration. (2006) (125)
- Limitations of translational accuracy (1996) (124)
- Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes (2000) (120)
- Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance (2003) (112)
- Homologous recombination between the tuf genes of Salmonella typhimurium. (1996) (102)
- Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus (2008) (97)
- Environmental and genetic modulation of the phenotypic expression of antibiotic resistance (2017) (97)
- Editorial: Bacterial pathogens, antibiotics and antibiotic resistance. (2017) (95)
- Genetic and Phenotypic Identification of Fusidic Acid-Resistant Mutants with the Small-Colony-Variant Phenotype in Staphylococcus aureus (2007) (94)
- Accumulation of mutants in “aging” bacterial colonies is due to growth under selection, not stress-induced mutagenesis (2008) (92)
- Discovery and preclinical development of new antibiotics (2014) (91)
- Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates. (2013) (90)
- Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli. (2005) (87)
- Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. (2018) (74)
- Mutants of elongation factor Tu promote ribosomal frameshifting and nonsense readthrough. (1987) (71)
- Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli (2017) (69)
- Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus (2009) (58)
- Dose-related selection of fluoroquinolone-resistant Escherichia coli. (2007) (56)
- Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis. (2015) (55)
- Mutations to kirromycin resistance occur in the interface of domains I and III of EF‐Tu·GTP (1994) (53)
- The Selective Advantage of Synonymous Codon Usage Bias in Salmonella (2016) (52)
- Mutant ribosomes can generate dominant kirromycin resistance (1991) (51)
- In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii (2019) (51)
- Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic. (2012) (49)
- Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium with Low Fitness In Vivo Are Defective in RpoS Induction (2003) (46)
- Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions. (2000) (43)
- Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects (2017) (43)
- Selection and Transmission of Antibiotic-Resistant Bacteria. (2017) (42)
- Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate (1993) (41)
- Growth and translation elongation rate are sensitive to the concentration of EF‐Tu (1993) (41)
- Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus (2017) (40)
- Both genes for EF-Tu in Salmonella typhimurium are individually dispensable for growth. (1990) (40)
- Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria (2012) (40)
- Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs (2016) (39)
- Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli (2017) (37)
- A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome (1993) (34)
- A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants. (2015) (34)
- Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics. (2005) (33)
- Selection and evolution of resistance to antimicrobial drugs (2014) (32)
- Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli (2006) (31)
- Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates (1997) (31)
- Antibiotic development and resistance. (2001) (30)
- Can phylogenetic type predict resistance development? (2011) (30)
- Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections (2021) (28)
- The role of EF-Tu and other translation components in determining translocation step size. (1990) (28)
- Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain. (2016) (27)
- Mutant forms of tufA and tufB independently suppress nonsense mutations. (1987) (27)
- Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus (2011) (26)
- Biological roles of translesion synthesis DNA polymerases in eubacteria (2010) (25)
- Impact of Homologous Recombination on Genome Organization and Stability (1999) (24)
- Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli. (2014) (23)
- Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli (2020) (23)
- Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution (2013) (22)
- The Origin of Mutants under Selection: Interactions of Mutation, Growth, and Selection. (2011) (22)
- Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium Have Low Levels of Heme and a Reduced Rate of Respiration and Are Sensitive to Oxidative Stress (2004) (22)
- Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli (2017) (22)
- Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model (2011) (22)
- Turnover of mRNAs is one of the essential functions of RNase E (2015) (21)
- Mutants of the RNA‐processing enzyme RNase E reverse the extreme slow‐growth phenotype caused by a mutant translation factor EF‐Tu (2008) (21)
- Mutants of EF‐Tu defective in binding aminoacyl‐tRNA (1996) (19)
- Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data (2017) (19)
- Missense substitutions lethal to essential functions of EF-Tu. (1991) (19)
- Effect of Translesion DNA Polymerases, Endonucleases and RpoS on Mutation Rates in Salmonella typhimurium (2010) (18)
- Suppression of a -1 frameshift mutation by a recessive tRNA suppressor which causes doublet decoding (1989) (18)
- Error‐prone EF‐Tu reduces in vivo enzyme activity and cellular growth rate (1991) (17)
- Autoregulation of the tufB operon in Salmonella (2016) (15)
- Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene (2020) (15)
- Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli (2018) (15)
- The processive kinetics of gene conversion in bacteria (2017) (14)
- Genetic characterization of frameshift suppressors with new decoding properties (1989) (14)
- Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice (2017) (14)
- Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. (2018) (13)
- Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium. (2004) (13)
- Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin (2020) (13)
- Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB (2018) (12)
- Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity. (2010) (12)
- The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation (2020) (12)
- Co‐evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella (2018) (12)
- tRNA-ribosome interactions. (1995) (11)
- Acetate Availability and Utilization Supports the Growth of Mutant Sub-Populations on Aging Bacterial Colonies (2014) (11)
- Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase. (2018) (10)
- Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli (2020) (10)
- The isolation and mapping of EF-Tu mutations in Salmonella typhimurium (2004) (10)
- Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes (2019) (9)
- Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB). (2017) (9)
- Effects of Antibiotic Resistance on Bacterial Fitness, Virulence, and Transmission (2008) (9)
- Temperature-Sensitive Mutants of RNase E in Salmonella enterica (2011) (9)
- Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu (2014) (9)
- Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice. (2020) (9)
- Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors. (2016) (8)
- Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance (2017) (8)
- Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility. (2014) (7)
- [Antibiotic resistance here to stay? Compensatory mutations restore virulence of resistant bacteria]. (1998) (7)
- Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate. (1993) (7)
- Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu (1990) (7)
- Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation. (2021) (6)
- Isopedopeptins A–H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria (2020) (6)
- Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis (2021) (6)
- Using the power of genetic suppressors to probe the essential functions of RNase E (2016) (6)
- Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium (2018) (5)
- Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella (2018) (5)
- Genetic Architecture and Fitness of Bacterial Interspecies Hybrids (2020) (4)
- Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues. (2020) (4)
- The States, Conformational Dynamics, and Fusidic Acid-Resistant Mutants of Elongation Factor G (2000) (4)
- ENABLE: an engine for European antibacterial drug discovery and development (2021) (4)
- Genetics: Location affects sporulation (2015) (4)
- Target alterations mediating antibiotic resistance (2001) (4)
- Fitness and virulence of antibiotic resistant bacteria. (2001) (3)
- The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium. (1991) (3)
- Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating Staphylococcus aureus infections (2020) (3)
- Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa (2023) (3)
- Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia. (2022) (3)
- Novel Mutants of EF-Tu (1989) (3)
- Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli. (2017) (3)
- Expression of the qepA1 gene is induced under antibiotic exposure (2021) (2)
- Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections (2022) (2)
- Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella. (2019) (2)
- Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella (2021) (2)
- Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria (2022) (2)
- Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents (2022) (2)
- Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response (2020) (2)
- Dose-related selection of fluoroquinolones (2007) (2)
- Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium. (2010) (1)
- Elongation Factors: Translation (2013) (1)
- A PKPD model characterizing the combined effects of colistin and ciprofloxacin on MG1655 wild type and a clinical isolate of E. coli (2015) (1)
- Increased bacterial fitness selected with antimicrobial drug resistance (2007) (1)
- The states, conformational dynamics and fusidic acid resistant mutants of EF-G (2000) (1)
- Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins (2021) (1)
- Towards the cloning of the calf prochymosin gene (1984) (1)
- Selection of strong mutators and of rifampicin-resistant mutants, during evolution of fluoroquinolone resistance in urinary tract Escherichia coli. (2007) (1)
- Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2) (2022) (1)
- Predicting mutant selection in competition experiments (2016) (1)
- Are PKPD models predictive across bacterial densities and strains - external evaluation of a PKPD model describing longitudinal in vitro data. (2016) (1)
- The Dynamic Bacterial Genome: Biological consequences for bacteria of homologous recombination (2005) (1)
- Resistance to fusidic acid can be linked to the Small Colony Variant (SCV) phenotype in Staphylococcus aureus (2007) (1)
- Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes (2022) (1)
- Erratum: The role of EF-Tu and other translation components in determining translocation step size (BBAEXP 92116) (Biochimica et Biophysica Acta, Vol 1050 (1990) 274-278)) (1990) (0)
- Extragenic suppressors of RNase E ts mutants (2011) (0)
- Impact of homologous recombination and gene conversion on genomic organisation and stability (1999) (0)
- Importance of acetate utilization for the growth of mutant sub-populations in aging bacterial colonies (2012) (0)
- Functional significance of leuS mutations in Escherichia coli resistance to ciprofloxacin. (2017) (0)
- MutantRibosomes CanGenerate DominantKirromycin Resistance (1991) (0)
- Antibacter ial Agents that Cause Miscoding by Binding at a New Ribosomal Site Graphical Abstract Highlights (0)
- Phenotypic and Genotypic Responses to Relocating a Highly-Expressed Bacterial Operon. (2017) (0)
- Experimental evolution identifies a new class of genes selected during the development of ciprofloxacin resistance in Escherichia coli (2015) (0)
- Kinetic properties of unusual ribosomal mutations affecting accuracy of translation (2006) (0)
- The Selective Advantage of Replichore Balance in Salmonella Typhimurium. (2017) (0)
- Environmental Conditions Promote Genetic Changes and Increase Resistance to β-lactam Antibiotics in Klebsiella oxytoca (2020) (0)
- New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus (2023) (0)
- Fitness cost: a possible explanation for the disappearance of multiresistant MRSA in Denmark during 1970–1975 (2009) (0)
- High frequencies of genome rearrangements in bacterial chromosomes (2012) (0)
- Using the power of genetic suppressors to probe the essential functions of RNase E (2015) (0)
- A secondary site rpoB mutation restricted to a multidrug-resistant outbreak strain restored the fitness defect of BCG harboring the rifampicin-conferring mutation, S531L (2014) (0)
- Turnover of mRNAs is an essential function of RNase E (2014) (0)
- A large chromosomal inversion causes the formation of an unstable tufA/B hybrid operon (2016) (0)
- Genetic and Phenotypic Identification of Fusidic Acid-Resistant Mutants with the Small-Colony-Variant Phenotype in Staphylococcus aureus (cid:1) (2007) (0)
- RNA polymerase mutations contribute to the evolution of ciprofloxacin resistance in Escherichia coli (2015) (0)
- Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution (2018) (0)
- Reduced levels of heme and respiration rate in elongation factor G mutants of Salmonella enterica serovar Typhimurium (2003) (0)
- A biased spectrum of mutations in acrR among ciprofloxacin-resistant isolates of Escherichia coli. (2017) (0)
- Adventures with Mutation and Selection in Beehive and Cow Country (2011) (0)
- Mutants ofelongation factor Tupromoteribosomal frameshifting (1987) (0)
- Fitness of novel classes of fusidic acid-resistant Staphylococcus aureus in vitro and in vivo (2007) (0)
- Urinary pH Warrants Therapeutic Window of EBL-1003 (Apramycin) in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis (2021) (0)
- Genetics of fitness-compensation in experimentally evolved marR mutants of Escherichia coli. (2017) (0)
- Corrigendum (2006) (0)
- Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB (2018) (0)
- Methods to Determine Mutational Trajectories After Experimental Evolution of Antibiotic Resistance. (2018) (0)
- Hypersensitivity of fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium to several classes of antibiotics (2003) (0)
- Co-evolution protects the tuf genes from inactivation by mobile genetic elements (2016) (0)
- Corrigendum: Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium (2019) (0)
- Comparative genomics and the development of novel antimicrobials (2008) (0)
- Suppression ofa -1 Frameshift Mutation bya Recessive tRNA Suppressor WhichCausesDoublet Decodingt (1989) (0)
- Muller's Ratchet Impairs Fitness of Bacteria (1995) (0)
- Fitness compensation in Fluoroquinolone resistant Escherichia coli by mutant RNA polymerase (2007) (0)
- STRUCTURE OF THERMUS THERMOPHILUS EF-G H573A (2000) (0)
- Some Chemical Treatments toReduce the Resistance ofGround Connections (1960) (0)
- Selection of Resistance By Very Low Levels of Antibiotics (2015) (0)
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