Diarmaid Hughes

Q: What Schools Are Affiliated With Diarmaid Hughes

Diarmaid Hughes is affiliated with the following schools: Uppsala University, California Institute of Technology, University of Oxford, Stanford University

Diarmaid Hughes's AcademicInfluence.com Rankings

Diarmaid Hughes

Chemistry

#4891

World Rank

#5985

Historical Rank

Organic Chemistry

#811

World Rank

#911

Historical Rank

chemistry Degrees

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Chemistry

Diarmaid Hughes's Degrees

Bachelors Chemistry University of Oxford
PhD Chemistry Stanford University

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Diarmaid Hughes's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Antibiotic resistance and its cost: is it possible to reverse resistance? (2010) (1843)
Selection of Resistant Bacteria at Very Low Antibiotic Concentrations (2011) (1267)
Microbiological effects of sublethal levels of antibiotics (2014) (1134)
Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. (2000) (442)
Mechanisms and consequences of bacterial resistance to antimicrobial peptides. (2016) (427)
Persistence of antibiotic resistance in bacterial populations. (2011) (365)
Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary Tract Infections (2003) (351)
Virulence of antibiotic-resistant Salmonella typhimurium. (1998) (343)
Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness (2009) (298)
Evolution of antibiotic resistance at non-lethal drug concentrations. (2012) (287)
Biological cost and compensatory evolution in fusidic acid‐resistant Staphylococcus aureus (2001) (265)
Gene amplification and adaptive evolution in bacteria. (2009) (249)
Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms (2015) (190)
Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes (2005) (163)
Muller's ratchet decreases fitness of a DNA-based microbe. (1996) (155)
Biological Cost of Single and Multiple Norfloxacin Resistance Mutations in Escherichia coli Implicated in Urinary Tract Infections (2005) (154)
Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium (1999) (151)
Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. (2000) (145)
Evolutionary Trajectories to Antibiotic Resistance. (2017) (145)
Selection of resistance at lethal and non-lethal antibiotic concentrations. (2012) (142)
Fitness‐compensatory mutations in rifampicin‐resistant RNA polymerase (2012) (136)
Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration. (2006) (125)
Limitations of translational accuracy (1996) (124)
Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes (2000) (120)
Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance (2003) (112)
Homologous recombination between the tuf genes of Salmonella typhimurium. (1996) (102)
Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus (2008) (97)
Environmental and genetic modulation of the phenotypic expression of antibiotic resistance (2017) (97)
Editorial: Bacterial pathogens, antibiotics and antibiotic resistance. (2017) (95)
Genetic and Phenotypic Identification of Fusidic Acid-Resistant Mutants with the Small-Colony-Variant Phenotype in Staphylococcus aureus (2007) (94)
Accumulation of mutants in “aging” bacterial colonies is due to growth under selection, not stress-induced mutagenesis (2008) (92)
Discovery and preclinical development of new antibiotics (2014) (91)
Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates. (2013) (90)
Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli. (2005) (87)
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. (2018) (74)
Mutants of elongation factor Tu promote ribosomal frameshifting and nonsense readthrough. (1987) (71)
Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli (2017) (69)
Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus (2009) (58)
Dose-related selection of fluoroquinolone-resistant Escherichia coli. (2007) (56)
Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis. (2015) (55)
Mutations to kirromycin resistance occur in the interface of domains I and III of EF‐Tu·GTP (1994) (53)
The Selective Advantage of Synonymous Codon Usage Bias in Salmonella (2016) (52)
Mutant ribosomes can generate dominant kirromycin resistance (1991) (51)
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii (2019) (51)
Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic. (2012) (49)
Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium with Low Fitness In Vivo Are Defective in RpoS Induction (2003) (46)
Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions. (2000) (43)
Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects (2017) (43)
Selection and Transmission of Antibiotic-Resistant Bacteria. (2017) (42)
Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate (1993) (41)
Growth and translation elongation rate are sensitive to the concentration of EF‐Tu (1993) (41)
Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus (2017) (40)
Both genes for EF-Tu in Salmonella typhimurium are individually dispensable for growth. (1990) (40)
Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria (2012) (40)
Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs (2016) (39)
Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli (2017) (37)
A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome (1993) (34)
A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants. (2015) (34)
Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics. (2005) (33)
Selection and evolution of resistance to antimicrobial drugs (2014) (32)
Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli (2006) (31)
Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates (1997) (31)
Antibiotic development and resistance. (2001) (30)
Can phylogenetic type predict resistance development? (2011) (30)
Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections (2021) (28)
The role of EF-Tu and other translation components in determining translocation step size. (1990) (28)
Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain. (2016) (27)
Mutant forms of tufA and tufB independently suppress nonsense mutations. (1987) (27)
Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus (2011) (26)
Biological roles of translesion synthesis DNA polymerases in eubacteria (2010) (25)
Impact of Homologous Recombination on Genome Organization and Stability (1999) (24)
Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli. (2014) (23)
Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli (2020) (23)
Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution (2013) (22)
The Origin of Mutants under Selection: Interactions of Mutation, Growth, and Selection. (2011) (22)
Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium Have Low Levels of Heme and a Reduced Rate of Respiration and Are Sensitive to Oxidative Stress (2004) (22)
Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli (2017) (22)
Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model (2011) (22)
Turnover of mRNAs is one of the essential functions of RNase E (2015) (21)
Mutants of the RNA‐processing enzyme RNase E reverse the extreme slow‐growth phenotype caused by a mutant translation factor EF‐Tu (2008) (21)
Mutants of EF‐Tu defective in binding aminoacyl‐tRNA (1996) (19)
Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data (2017) (19)
Missense substitutions lethal to essential functions of EF-Tu. (1991) (19)
Effect of Translesion DNA Polymerases, Endonucleases and RpoS on Mutation Rates in Salmonella typhimurium (2010) (18)
Suppression of a -1 frameshift mutation by a recessive tRNA suppressor which causes doublet decoding (1989) (18)
Error‐prone EF‐Tu reduces in vivo enzyme activity and cellular growth rate (1991) (17)
Autoregulation of the tufB operon in Salmonella (2016) (15)
Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene (2020) (15)
Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli (2018) (15)
The processive kinetics of gene conversion in bacteria (2017) (14)
Genetic characterization of frameshift suppressors with new decoding properties (1989) (14)
Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice (2017) (14)
Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. (2018) (13)
Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium. (2004) (13)
Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin (2020) (13)
Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB (2018) (12)
Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity. (2010) (12)
The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation (2020) (12)
Co‐evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella (2018) (12)
tRNA-ribosome interactions. (1995) (11)
Acetate Availability and Utilization Supports the Growth of Mutant Sub-Populations on Aging Bacterial Colonies (2014) (11)
Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase. (2018) (10)
Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli (2020) (10)
The isolation and mapping of EF-Tu mutations in Salmonella typhimurium (2004) (10)
Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes (2019) (9)
Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB). (2017) (9)
Effects of Antibiotic Resistance on Bacterial Fitness, Virulence, and Transmission (2008) (9)
Temperature-Sensitive Mutants of RNase E in Salmonella enterica (2011) (9)
Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu (2014) (9)
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice. (2020) (9)
Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors. (2016) (8)
Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance (2017) (8)
Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility. (2014) (7)
[Antibiotic resistance here to stay? Compensatory mutations restore virulence of resistant bacteria]. (1998) (7)
Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate. (1993) (7)
Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu (1990) (7)
Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation. (2021) (6)
Isopedopeptins A–H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria (2020) (6)
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis (2021) (6)
Using the power of genetic suppressors to probe the essential functions of RNase E (2016) (6)
Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium (2018) (5)
Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella (2018) (5)
Genetic Architecture and Fitness of Bacterial Interspecies Hybrids (2020) (4)
Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues. (2020) (4)
The States, Conformational Dynamics, and Fusidic Acid-Resistant Mutants of Elongation Factor G (2000) (4)
ENABLE: an engine for European antibacterial drug discovery and development (2021) (4)
Genetics: Location affects sporulation (2015) (4)
Target alterations mediating antibiotic resistance (2001) (4)
Fitness and virulence of antibiotic resistant bacteria. (2001) (3)
The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium. (1991) (3)
Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating Staphylococcus aureus infections (2020) (3)
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa (2023) (3)
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia. (2022) (3)
Novel Mutants of EF-Tu (1989) (3)
Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli. (2017) (3)
Expression of the qepA1 gene is induced under antibiotic exposure (2021) (2)
Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections (2022) (2)
Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella. (2019) (2)
Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella (2021) (2)
Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria (2022) (2)
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents (2022) (2)
Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response (2020) (2)
Dose-related selection of fluoroquinolones (2007) (2)
Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium. (2010) (1)
Elongation Factors: Translation (2013) (1)
A PKPD model characterizing the combined effects of colistin and ciprofloxacin on MG1655 wild type and a clinical isolate of E. coli (2015) (1)
Increased bacterial fitness selected with antimicrobial drug resistance (2007) (1)
The states, conformational dynamics and fusidic acid resistant mutants of EF-G (2000) (1)
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins (2021) (1)
Towards the cloning of the calf prochymosin gene (1984) (1)
Selection of strong mutators and of rifampicin-resistant mutants, during evolution of fluoroquinolone resistance in urinary tract Escherichia coli. (2007) (1)
Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2) (2022) (1)
Predicting mutant selection in competition experiments (2016) (1)
Are PKPD models predictive across bacterial densities and strains - external evaluation of a PKPD model describing longitudinal in vitro data. (2016) (1)
The Dynamic Bacterial Genome: Biological consequences for bacteria of homologous recombination (2005) (1)
Resistance to fusidic acid can be linked to the Small Colony Variant (SCV) phenotype in Staphylococcus aureus (2007) (1)
Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes (2022) (1)
Erratum: The role of EF-Tu and other translation components in determining translocation step size (BBAEXP 92116) (Biochimica et Biophysica Acta, Vol 1050 (1990) 274-278)) (1990) (0)
Extragenic suppressors of RNase E ts mutants (2011) (0)
Impact of homologous recombination and gene conversion on genomic organisation and stability (1999) (0)
Importance of acetate utilization for the growth of mutant sub-populations in aging bacterial colonies (2012) (0)
Functional significance of leuS mutations in Escherichia coli resistance to ciprofloxacin. (2017) (0)
MutantRibosomes CanGenerate DominantKirromycin Resistance (1991) (0)
Antibacter ial Agents that Cause Miscoding by Binding at a New Ribosomal Site Graphical Abstract Highlights (0)
Phenotypic and Genotypic Responses to Relocating a Highly-Expressed Bacterial Operon. (2017) (0)
Experimental evolution identifies a new class of genes selected during the development of ciprofloxacin resistance in Escherichia coli (2015) (0)
Kinetic properties of unusual ribosomal mutations affecting accuracy of translation (2006) (0)
The Selective Advantage of Replichore Balance in Salmonella Typhimurium. (2017) (0)
Environmental Conditions Promote Genetic Changes and Increase Resistance to β-lactam Antibiotics in Klebsiella oxytoca (2020) (0)
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus (2023) (0)
Fitness cost: a possible explanation for the disappearance of multiresistant MRSA in Denmark during 1970–1975 (2009) (0)
High frequencies of genome rearrangements in bacterial chromosomes (2012) (0)
Using the power of genetic suppressors to probe the essential functions of RNase E (2015) (0)
A secondary site rpoB mutation restricted to a multidrug-resistant outbreak strain restored the fitness defect of BCG harboring the rifampicin-conferring mutation, S531L (2014) (0)
Turnover of mRNAs is an essential function of RNase E (2014) (0)
A large chromosomal inversion causes the formation of an unstable tufA/B hybrid operon (2016) (0)
Genetic and Phenotypic Identiﬁcation of Fusidic Acid-Resistant Mutants with the Small-Colony-Variant Phenotype in Staphylococcus aureus (cid:1) (2007) (0)
RNA polymerase mutations contribute to the evolution of ciprofloxacin resistance in Escherichia coli (2015) (0)
Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution (2018) (0)
Reduced levels of heme and respiration rate in elongation factor G mutants of Salmonella enterica serovar Typhimurium (2003) (0)
A biased spectrum of mutations in acrR among ciprofloxacin-resistant isolates of Escherichia coli. (2017) (0)
Adventures with Mutation and Selection in Beehive and Cow Country (2011) (0)
Mutants ofelongation factor Tupromoteribosomal frameshifting (1987) (0)
Fitness of novel classes of fusidic acid-resistant Staphylococcus aureus in vitro and in vivo (2007) (0)
Urinary pH Warrants Therapeutic Window of EBL-1003 (Apramycin) in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis (2021) (0)
Genetics of fitness-compensation in experimentally evolved marR mutants of Escherichia coli. (2017) (0)
Corrigendum (2006) (0)
Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB (2018) (0)
Methods to Determine Mutational Trajectories After Experimental Evolution of Antibiotic Resistance. (2018) (0)
Hypersensitivity of fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium to several classes of antibiotics (2003) (0)
Co-evolution protects the tuf genes from inactivation by mobile genetic elements (2016) (0)
Corrigendum: Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium (2019) (0)
Comparative genomics and the development of novel antimicrobials (2008) (0)
Suppression ofa -1 Frameshift Mutation bya Recessive tRNA Suppressor WhichCausesDoublet Decodingt (1989) (0)
Muller's Ratchet Impairs Fitness of Bacteria (1995) (0)
Fitness compensation in Fluoroquinolone resistant Escherichia coli by mutant RNA polymerase (2007) (0)
STRUCTURE OF THERMUS THERMOPHILUS EF-G H573A (2000) (0)
Some Chemical Treatments toReduce the Resistance ofGround Connections (1960) (0)
Selection of Resistance By Very Low Levels of Antibiotics (2015) (0)

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