Didier Picard

Q: What Schools Are Affiliated With Didier Picard

Didier Picard is affiliated with the following schools: ETH Zurich, University of California, San Francisco, University of Geneva, Karolinska Institute, University of Zurich

Didier Picard's AcademicInfluence.com Rankings

Didier Picard

Philosophy

#7872

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#11147

Historical Rank

Logic

#4905

World Rank

#6243

Historical Rank

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Philosophy

Didier Picard's Degrees

PhD Molecular Biology University of Geneva
Masters Biochemistry University of Zurich
Bachelors Biology University of Zurich

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Didier Picard's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. (1996) (1042)
Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor. (1987) (920)
Reduced levels of hsp90 compromise steroid receptor action in vivo (1990) (780)
Heat-shock protein 90, a chaperone for folding and regulation (2002) (763)
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells (1989) (456)
The glucocorticoid responses are shaped by molecular chaperones (2007) (389)
The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells* (2004) (381)
A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor (1988) (371)
The unfolding stories of GPR30, a new membrane-bound estrogen receptor. (2010) (359)
The Hsp90‐binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo (2003) (337)
The G Protein-Coupled Receptor GPR30 Mediates the Proliferative Effects Induced by 17β-Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells (2006) (319)
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF (2009) (308)
RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. (2002) (290)
A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene (1984) (281)
17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30 (2006) (267)
Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors. (1990) (241)
Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins. (1988) (214)
Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. (2001) (213)
Vectors for constitutive and inducible gene expression in yeast. (1991) (212)
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis (2013) (210)
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine (2011) (209)
Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin. (1993) (198)
Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. (2010) (194)
Fusion of GAL4-VP16 to a steroid-binding domain provides a tool for gratuitous induction of galactose-responsive genes in yeast. (1993) (187)
Chaperoning steroid hormone action (2006) (183)
A simulation model of the three-dimensional architecture of the maize root system (1989) (165)
Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha. (1999) (155)
miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA (2009) (150)
The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse (2010) (142)
The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter (2013) (139)
Ligand-independent Activation of Steroid Receptors: New Roles for Old Players (1999) (135)
Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices. (2005) (135)
Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells. (2008) (129)
Cdc37 goes beyond Hsp90 and kinases (2003) (126)
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. (2006) (124)
Hsp90 is required for pheromone signaling in yeast. (1998) (122)
Heat shock protein hsp90 regulates dioxin receptor function in vivo. (1995) (121)
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. (2005) (120)
Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90. (1993) (120)
Regulation of protein function through expression of chimaeric proteins. (1994) (119)
The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA‐dependent kinase PKR (2001) (119)
Regulation of protein activities by fusion to steroid binding domains. (1994) (118)
Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast. (1996) (117)
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs (2004) (108)
miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA (2009) (107)
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells. (2014) (105)
The Hsp90 Cochaperone p23 Is Essential for Perinatal Survival (2006) (99)
Hsp104 Interacts with Hsp90 Cochaperones in Respiring Yeast (2001) (97)
During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation (1986) (88)
The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes (2011) (87)
Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation (2002) (85)
Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. (1991) (80)
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development (2018) (80)
CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP. (2010) (79)
p23/Sba1p Protects against Hsp90 Inhibitors Independently of Its Intrinsic Chaperone Activity (2008) (79)
Steroid-binding domains for regulating the functions of heterologous proteins in cis. (1993) (79)
Fungi and animals may share a common ancestor to nuclear receptors. (2006) (74)
Metformin reverses TRAP1 mutation‐associated alterations in mitochondrial function in Parkinson's disease (2017) (72)
Dendrogenin A drives LXR to trigger lethal autophagy in cancers (2017) (72)
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. (2008) (71)
A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. (1984) (67)
Hsp90 Binds and Regulates the Ligand-Inducible α Subunit of Eukaryotic Translation Initiation Factor Kinase Gcn2 (1999) (64)
The molecular chaperone Cdc37 is required for Ste11 function and pheromone‐induced cell cycle arrest (2000) (63)
Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation (1994) (62)
Molecular and Clinical Characteristics in 46 Families Affected with Peutz–Jeghers Syndrome (2007) (62)
Posttranslational regulation of proteins by fusions to steroid-binding domains. (2000) (61)
GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response (2016) (60)
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy (2020) (60)
Cell‐type preference of immunoglobulin kappa and lambda gene promoters. (1985) (60)
Estradiol Decreases IGF-1 and IGF-1 Receptor Expression in Rat Aortic Smooth Muscle Cells (2000) (59)
Estrogen Receptor Mediates the Proliferative but Not the Cytotoxic Dose-Dependent Effects of Two Major Phytoestrogens on Human Breast Cancer Cells (2001) (58)
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation (2019) (57)
Implementation of liquid chromatography-high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial. (2020) (57)
Hormone‐conditional transformation by fusion proteins of c‐Abl and its transforming variants. (1993) (54)
Minireview: Tipping the balance: ligand-independent activation of steroid receptors. (2015) (53)
The Hsp90 Co-Chaperones Cdc37 and Sti1 Interact Physically and Genetically (2002) (51)
Functional Analysis of the Yeast 40 kDa Cyclophilin Cyp40 and Its Role for Viability and Steroid Receptor Regulation (1997) (49)
Correct transcription of a cloned mouse immunoglobulin gene in vivo. (1983) (48)
An inducible expression vector for both fission and budding yeast. (1990) (48)
The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. (2002) (47)
LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP (2016) (47)
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis (2020) (46)
Hsp90 Binds and Regulates Gcn2, the Ligand-Inducible Kinase of the α Subunit of Eukaryotic Translation Initiation Factor 2 (2000) (44)
A Non-Radioactive Method for Inexpensive Quantitative RT-PCR (1999) (44)
Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells. (2004) (44)
Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers. (2016) (43)
SPBP Is a Phosphoserine-Specific Repressor of Estrogen Receptor α (2005) (43)
Steroid receptors. How to be both a receptor and a transcription factor. (1989) (42)
Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis. (2016) (41)
The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities. (2009) (41)
Hsp90 invades the outside (2004) (40)
Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors. (2014) (39)
Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy (2013) (38)
Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90. (2006) (37)
A scoring approach for multi-platform acquisition in metabolomics. (2019) (35)
Genomics of Signaling Crosstalk of Estrogen Receptor α in Breast Cancer Cells (2008) (34)
Evidence for transient requirement of the IgH enhancer. (1985) (34)
Molecular endocrinology: Steroids tickle cells inside and out (1998) (32)
Does undersowing winter wheat with a cover crop increase competition for resources and is it compatible with high yield (2010) (31)
Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles. (2016) (31)
Steroid-independent activation of steroid receptors in mammalian and yeast cells and in breast cancer. (1997) (31)
Ligand-regulated nonspecific inactivation of receptor function: a versatile mechanism for signal transduction. (1988) (30)
A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation (2016) (30)
Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma‐fibroblast hybrid cells. (1988) (30)
2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex. (2006) (29)
Bioactive steroids as contaminants of the common carbon source galactose. (1998) (29)
Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response. (1995) (28)
Nuclear receptors : a practical approach (1999) (28)
Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast. (1995) (26)
Preface to Hsp90. (2012) (26)
Multidirectional interplay between nuclear receptors and microRNAs. (2010) (26)
The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase (2001) (26)
A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells (2017) (25)
Unrearranged immunoglobulin lambda variable region is transcribed in kappa‐producing myelomas. (1984) (24)
A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha. (2005) (23)
TROD: T7 RNAi Oligo Designer (2004) (21)
The G Protein-Coupled Receptor GPR 30 Mediates the Proliferative Effects Induced by 17-Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells (2006) (21)
Two compounds commonly used for phospholipase C inhibition activate the nuclear estrogen receptors. (1999) (20)
Alpha-complemented beta-galactosidase. An in vivo model substrate for the molecular chaperone heat-shock protein 90 in yeast. (1999) (20)
Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells (2002) (19)
Viral and cellular transcription enhancers. (1985) (18)
The hormone binding domain of the mineralocorticoid receptor can regulate heterologous activities in cis. (1994) (17)
The Anti-Estrogen Hydroxytamoxifen Is a Potent Antagonist in a Novel Yeast System (1999) (17)
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling (2019) (17)
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity (2018) (17)
Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling (2003) (17)
Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model (2017) (16)
A yeast-based bioassay for the determination of functional and non-functional estrogen receptors. (1999) (15)
The cell-specific activity of the estrogen receptor α may be fine-tuned by phosphorylation-induced structural gymnastics (2006) (14)
A recombinant yeast strain as a short term bioassay to assess estrogen-like activity of xenobiotics. (2004) (14)
Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation (2011) (13)
Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes (2018) (13)
The Role of Heat-Shock Proteins in the Regulation of Steroid Receptor Function (1998) (13)
Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development (2020) (12)
Influenza Virus Infection Induces the Nuclear Relocalization of the Hsp90 Co-Chaperone p23 and Inhibits the Glucocorticoid Receptor Response (2011) (11)
Prospect for conservation agriculture in Northern and Eastern European countries, lessons of Kassa (2006) (10)
Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23 (2017) (10)
In Situ Study of Corn Seedling Root and Shoot Growth by Neutron Radiography1 (1980) (10)
Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis (2021) (9)
The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration (2021) (9)
Myeloma χ gene transcription is blocked upon fusion with fibroblasts (1989) (9)
A Global View of the Proteome Perturbations by Hsp90 Inhibitors (2014) (9)
Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry (2017) (9)
A stress protein interface of innate immunity (2008) (8)
Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol. (2017) (7)
ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1 (2018) (7)
Overview of molecular chaperones in health and disease (2014) (7)
Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance (2022) (5)
Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life (2022) (4)
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERα-Positive Breast Cancer (2022) (4)
Evidence fortransient requirement oftheIgHenhancer (1985) (4)
The Dalia Development Challenges and Achievements (2007) (3)
Evaluation of the organic matter supplied to the soil by the decay of the roots of an intensively managedPanicum Maximum sward (1979) (3)
The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors (2022) (3)
Growth inhibition by Abl requires an interplay of its SH2 and tyrosine kinase domains (1996) (3)
CHAPTER 1:Overview of Molecular Chaperones in Health and Disease (2013) (3)
siRNA production by in vitro transcription (2005) (3)
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis (2019) (3)
The Atomically Precise Gold/Captopril Nanocluster Au25(Capt)18 Gains Anticancer Activity by Inhibiting Mitochondrial Oxidative Phosphorylation. (2022) (2)
Ligand-Independent Activation of the Estrogen Receptor: Activation by Epidermal Growth Factor and Dopamine (1998) (2)
Oestrogen receptor is required for androgen-stimulated proliferation of LNCaP prostate cancer cells (2004) (2)
H2B monoubiquitination: t'ub or not t'ub for inducible enhancers (2017) (2)
Automatic Endoscope For The In Situ Study Of Plant Roots (1988) (2)
CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells (2022) (2)
Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer (2022) (1)
Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes (2018) (1)
Myeloma kappa gene transcription is blocked upon fusion with fibroblasts. (1989) (1)
Molecular endocrinology: Two orphans find a home (1998) (1)
AF291 and AE391 single-chain antibodies recognize the HA tag by Western blotting (2019) (1)
Phosphorylation of the Hsp90 co-chaperone Hop changes its conformational dynamics and biological function. (2022) (1)
Erratum to “Does undersowing winter wheat with a cover crop increase competition for resources and is it compatible with high yield?” [Field Crops Res. 115 (2010) 9–18] (2010) (1)
Yield development in the main annual crops. (1994) (0)
P0956 : MIR-22 deficiency exacerbates systemic and hepatic metabolic disorders associated with diet-induced obesity in mice (2015) (0)
The role of miRNAs in hormone signaling (2010) (0)
Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress (2023) (0)
Dendrogenin A drives LXR to trigger lethal autophagy in cancers (2017) (0)
Didier Picard p 23 / Sba 1 p protects against Hsp 90 inhibitors (2008) (0)
Cell Line with ElA-Dependent Conditional Proliferation (0)
Molecular analysis of the glucocorticoid receptor (1989) (0)
Oral infections and CVD. (2000) (0)
H90-10 single-chain antibody recognizes Hsp90beta by immunoprecipitation and Western blotting (2021) (0)
AI179 single-chain antibody recognizes the Myc tag by Western blotting (2019) (0)
Experimental biology and medicine. Vol. I. Morphological and Biochemical aspects of cytodifferentiation: E. Hagen, W. Wechsler and F. Zilliken (Editors). (Karger, Basel, 1967, 271 p., $8.40) (1969) (0)
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling (2019) (0)
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis (2020) (0)
Reference TROD : T 7 RNAi oligo designer (2017) (0)
G.P.105 Preclinical evaluation of tamoxifen and other selective estrogen receptor modulators in mdx5Cv dystrophic mice (2014) (0)
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development (2018) (0)
Signal transduction bysteroid hormones: nuclear localization isdifferentially regulated inestrogen andglucocorticoid receptors (1990) (0)
HSP90 chaperone cycle for steroid hormone receptors (SHR) (2017) (0)
A web application to manage a database for liquid nitrogen tanks (2004) (0)
A Single Post-Translational Modification with Far-Reaching Effects on the Assembly of a Multiprotein Chaperone Complex: A Mechanistic View from the Integration of Computation and Experiments (2022) (0)
S153: DECRYPTING THE ROLE OF HSP90Α AND Β ISOFORMS TO OVERCOME RESISTANCE IN BCR-ABL1 LEUKEMIA (2022) (0)
The G Protein-Coupled Receptor GPR30 Mediates the Proliferative Effects Induced by 17 (cid:1) -Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells (2006) (0)
Possibility of determining a rooting characteristic from a limited number of samples in root dynamics investigations on crops. (1977) (0)
Root dynamics of Panicum maximum Jacq. 2. Annual rhythm of primary adventitious root formation and the development of the root mass for an intensively exploited prairie. (1977) (0)
Rapport de mission en Chine (4-24 avril 1997) (1997) (0)
Maize physiology and production. (1990) (0)
Report on a visit to China (4-24 April 1997) (1997) (0)
Dunbar: A study in second phase North Sea development (1994) (0)
17 beta -Estradiol, Genistein and 4-Hydroxytamoxifen induce proliferative effects in thyroid cancer cells via G protein couplet-receptor GPR30. (2006) (0)
Method and apparatus for recovering a plane wrecks (1983) (0)
The regional and territorial development, a multidisciplinary challenge (2014) (0)
100 and 50 years ago (1998) (0)
Method and device for removal of crashed aircraft (1983) (0)
An underground exploration of the endoscope type, in particular for the study of the plants rooting in situ (1984) (0)

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What Schools Are Affiliated With Didier Picard?

Didier Picard is affiliated with the following schools:

Didier Picard's Academic­Influence.com Rankings