Didier Picard
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Philosophy
Didier Picard's Degrees
- PhD Molecular Biology University of Geneva
- Masters Biochemistry University of Zurich
- Bachelors Biology University of Zurich
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(Suggest an Edit or Addition)Didier Picard's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. (1996) (1042)
- Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor. (1987) (920)
- Reduced levels of hsp90 compromise steroid receptor action in vivo (1990) (780)
- Heat-shock protein 90, a chaperone for folding and regulation (2002) (763)
- Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells (1989) (456)
- The glucocorticoid responses are shaped by molecular chaperones (2007) (389)
- The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells* (2004) (381)
- A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor (1988) (371)
- The unfolding stories of GPR30, a new membrane-bound estrogen receptor. (2010) (359)
- The Hsp90‐binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo (2003) (337)
- The G Protein-Coupled Receptor GPR30 Mediates the Proliferative Effects Induced by 17β-Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells (2006) (319)
- Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF (2009) (308)
- RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. (2002) (290)
- A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene (1984) (281)
- 17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30 (2006) (267)
- Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors. (1990) (241)
- Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins. (1988) (214)
- Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. (2001) (213)
- Vectors for constitutive and inducible gene expression in yeast. (1991) (212)
- Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis (2013) (210)
- An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine (2011) (209)
- Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin. (1993) (198)
- Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. (2010) (194)
- Fusion of GAL4-VP16 to a steroid-binding domain provides a tool for gratuitous induction of galactose-responsive genes in yeast. (1993) (187)
- Chaperoning steroid hormone action (2006) (183)
- A simulation model of the three-dimensional architecture of the maize root system (1989) (165)
- Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha. (1999) (155)
- miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA (2009) (150)
- The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse (2010) (142)
- The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter (2013) (139)
- Ligand-independent Activation of Steroid Receptors: New Roles for Old Players (1999) (135)
- Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices. (2005) (135)
- Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells. (2008) (129)
- Cdc37 goes beyond Hsp90 and kinases (2003) (126)
- The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. (2006) (124)
- Hsp90 is required for pheromone signaling in yeast. (1998) (122)
- Heat shock protein hsp90 regulates dioxin receptor function in vivo. (1995) (121)
- LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. (2005) (120)
- Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90. (1993) (120)
- Regulation of protein function through expression of chimaeric proteins. (1994) (119)
- The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA‐dependent kinase PKR (2001) (119)
- Regulation of protein activities by fusion to steroid binding domains. (1994) (118)
- Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast. (1996) (117)
- The protein kinase PKR: a molecular clock that sequentially activates survival and death programs (2004) (108)
- miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA (2009) (107)
- Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells. (2014) (105)
- The Hsp90 Cochaperone p23 Is Essential for Perinatal Survival (2006) (99)
- Hsp104 Interacts with Hsp90 Cochaperones in Respiring Yeast (2001) (97)
- During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation (1986) (88)
- The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes (2011) (87)
- Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation (2002) (85)
- Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. (1991) (80)
- Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development (2018) (80)
- CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP. (2010) (79)
- p23/Sba1p Protects against Hsp90 Inhibitors Independently of Its Intrinsic Chaperone Activity (2008) (79)
- Steroid-binding domains for regulating the functions of heterologous proteins in cis. (1993) (79)
- Fungi and animals may share a common ancestor to nuclear receptors. (2006) (74)
- Metformin reverses TRAP1 mutation‐associated alterations in mitochondrial function in Parkinson's disease (2017) (72)
- Dendrogenin A drives LXR to trigger lethal autophagy in cancers (2017) (72)
- The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. (2008) (71)
- A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. (1984) (67)
- Hsp90 Binds and Regulates the Ligand-Inducible α Subunit of Eukaryotic Translation Initiation Factor Kinase Gcn2 (1999) (64)
- The molecular chaperone Cdc37 is required for Ste11 function and pheromone‐induced cell cycle arrest (2000) (63)
- Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation (1994) (62)
- Molecular and Clinical Characteristics in 46 Families Affected with Peutz–Jeghers Syndrome (2007) (62)
- Posttranslational regulation of proteins by fusions to steroid-binding domains. (2000) (61)
- GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response (2016) (60)
- Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy (2020) (60)
- Cell‐type preference of immunoglobulin kappa and lambda gene promoters. (1985) (60)
- Estradiol Decreases IGF-1 and IGF-1 Receptor Expression in Rat Aortic Smooth Muscle Cells (2000) (59)
- Estrogen Receptor Mediates the Proliferative but Not the Cytotoxic Dose-Dependent Effects of Two Major Phytoestrogens on Human Breast Cancer Cells (2001) (58)
- The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation (2019) (57)
- Implementation of liquid chromatography-high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial. (2020) (57)
- Hormone‐conditional transformation by fusion proteins of c‐Abl and its transforming variants. (1993) (54)
- Minireview: Tipping the balance: ligand-independent activation of steroid receptors. (2015) (53)
- The Hsp90 Co-Chaperones Cdc37 and Sti1 Interact Physically and Genetically (2002) (51)
- Functional Analysis of the Yeast 40 kDa Cyclophilin Cyp40 and Its Role for Viability and Steroid Receptor Regulation (1997) (49)
- Correct transcription of a cloned mouse immunoglobulin gene in vivo. (1983) (48)
- An inducible expression vector for both fission and budding yeast. (1990) (48)
- The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. (2002) (47)
- LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP (2016) (47)
- The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis (2020) (46)
- Hsp90 Binds and Regulates Gcn2, the Ligand-Inducible Kinase of the α Subunit of Eukaryotic Translation Initiation Factor 2 (2000) (44)
- A Non-Radioactive Method for Inexpensive Quantitative RT-PCR (1999) (44)
- Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells. (2004) (44)
- Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers. (2016) (43)
- SPBP Is a Phosphoserine-Specific Repressor of Estrogen Receptor α (2005) (43)
- Steroid receptors. How to be both a receptor and a transcription factor. (1989) (42)
- Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis. (2016) (41)
- The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities. (2009) (41)
- Hsp90 invades the outside (2004) (40)
- Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors. (2014) (39)
- Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy (2013) (38)
- Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90. (2006) (37)
- A scoring approach for multi-platform acquisition in metabolomics. (2019) (35)
- Genomics of Signaling Crosstalk of Estrogen Receptor α in Breast Cancer Cells (2008) (34)
- Evidence for transient requirement of the IgH enhancer. (1985) (34)
- Molecular endocrinology: Steroids tickle cells inside and out (1998) (32)
- Does undersowing winter wheat with a cover crop increase competition for resources and is it compatible with high yield (2010) (31)
- Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles. (2016) (31)
- Steroid-independent activation of steroid receptors in mammalian and yeast cells and in breast cancer. (1997) (31)
- Ligand-regulated nonspecific inactivation of receptor function: a versatile mechanism for signal transduction. (1988) (30)
- A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation (2016) (30)
- Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma‐fibroblast hybrid cells. (1988) (30)
- 2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex. (2006) (29)
- Bioactive steroids as contaminants of the common carbon source galactose. (1998) (29)
- Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response. (1995) (28)
- Nuclear receptors : a practical approach (1999) (28)
- Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast. (1995) (26)
- Preface to Hsp90. (2012) (26)
- Multidirectional interplay between nuclear receptors and microRNAs. (2010) (26)
- The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase (2001) (26)
- A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells (2017) (25)
- Unrearranged immunoglobulin lambda variable region is transcribed in kappa‐producing myelomas. (1984) (24)
- A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha. (2005) (23)
- TROD: T7 RNAi Oligo Designer (2004) (21)
- The G Protein-Coupled Receptor GPR 30 Mediates the Proliferative Effects Induced by 17-Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells (2006) (21)
- Two compounds commonly used for phospholipase C inhibition activate the nuclear estrogen receptors. (1999) (20)
- Alpha-complemented beta-galactosidase. An in vivo model substrate for the molecular chaperone heat-shock protein 90 in yeast. (1999) (20)
- Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells (2002) (19)
- Viral and cellular transcription enhancers. (1985) (18)
- The hormone binding domain of the mineralocorticoid receptor can regulate heterologous activities in cis. (1994) (17)
- The Anti-Estrogen Hydroxytamoxifen Is a Potent Antagonist in a Novel Yeast System (1999) (17)
- Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling (2019) (17)
- The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity (2018) (17)
- Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling (2003) (17)
- Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model (2017) (16)
- A yeast-based bioassay for the determination of functional and non-functional estrogen receptors. (1999) (15)
- The cell-specific activity of the estrogen receptor α may be fine-tuned by phosphorylation-induced structural gymnastics (2006) (14)
- A recombinant yeast strain as a short term bioassay to assess estrogen-like activity of xenobiotics. (2004) (14)
- Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation (2011) (13)
- Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes (2018) (13)
- The Role of Heat-Shock Proteins in the Regulation of Steroid Receptor Function (1998) (13)
- Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development (2020) (12)
- Influenza Virus Infection Induces the Nuclear Relocalization of the Hsp90 Co-Chaperone p23 and Inhibits the Glucocorticoid Receptor Response (2011) (11)
- Prospect for conservation agriculture in Northern and Eastern European countries, lessons of Kassa (2006) (10)
- Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23 (2017) (10)
- In Situ Study of Corn Seedling Root and Shoot Growth by Neutron Radiography1 (1980) (10)
- Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis (2021) (9)
- The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration (2021) (9)
- Myeloma χ gene transcription is blocked upon fusion with fibroblasts (1989) (9)
- A Global View of the Proteome Perturbations by Hsp90 Inhibitors (2014) (9)
- Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry (2017) (9)
- A stress protein interface of innate immunity (2008) (8)
- Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol. (2017) (7)
- ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1 (2018) (7)
- Overview of molecular chaperones in health and disease (2014) (7)
- Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance (2022) (5)
- Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life (2022) (4)
- Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERα-Positive Breast Cancer (2022) (4)
- Evidence fortransient requirement oftheIgHenhancer (1985) (4)
- The Dalia Development Challenges and Achievements (2007) (3)
- Evaluation of the organic matter supplied to the soil by the decay of the roots of an intensively managedPanicum Maximum sward (1979) (3)
- The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors (2022) (3)
- Growth inhibition by Abl requires an interplay of its SH2 and tyrosine kinase domains (1996) (3)
- CHAPTER 1:Overview of Molecular Chaperones in Health and Disease (2013) (3)
- siRNA production by in vitro transcription (2005) (3)
- The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis (2019) (3)
- The Atomically Precise Gold/Captopril Nanocluster Au25(Capt)18 Gains Anticancer Activity by Inhibiting Mitochondrial Oxidative Phosphorylation. (2022) (2)
- Ligand-Independent Activation of the Estrogen Receptor: Activation by Epidermal Growth Factor and Dopamine (1998) (2)
- Oestrogen receptor is required for androgen-stimulated proliferation of LNCaP prostate cancer cells (2004) (2)
- H2B monoubiquitination: t'ub or not t'ub for inducible enhancers (2017) (2)
- Automatic Endoscope For The In Situ Study Of Plant Roots (1988) (2)
- CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells (2022) (2)
- Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer (2022) (1)
- Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes (2018) (1)
- Myeloma kappa gene transcription is blocked upon fusion with fibroblasts. (1989) (1)
- Molecular endocrinology: Two orphans find a home (1998) (1)
- AF291 and AE391 single-chain antibodies recognize the HA tag by Western blotting (2019) (1)
- Phosphorylation of the Hsp90 co-chaperone Hop changes its conformational dynamics and biological function. (2022) (1)
- Erratum to “Does undersowing winter wheat with a cover crop increase competition for resources and is it compatible with high yield?” [Field Crops Res. 115 (2010) 9–18] (2010) (1)
- Yield development in the main annual crops. (1994) (0)
- P0956 : MIR-22 deficiency exacerbates systemic and hepatic metabolic disorders associated with diet-induced obesity in mice (2015) (0)
- The role of miRNAs in hormone signaling (2010) (0)
- Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress (2023) (0)
- Dendrogenin A drives LXR to trigger lethal autophagy in cancers (2017) (0)
- Didier Picard p 23 / Sba 1 p protects against Hsp 90 inhibitors (2008) (0)
- Cell Line with ElA-Dependent Conditional Proliferation (0)
- Molecular analysis of the glucocorticoid receptor (1989) (0)
- Oral infections and CVD. (2000) (0)
- H90-10 single-chain antibody recognizes Hsp90beta by immunoprecipitation and Western blotting (2021) (0)
- AI179 single-chain antibody recognizes the Myc tag by Western blotting (2019) (0)
- Experimental biology and medicine. Vol. I. Morphological and Biochemical aspects of cytodifferentiation: E. Hagen, W. Wechsler and F. Zilliken (Editors). (Karger, Basel, 1967, 271 p., $8.40) (1969) (0)
- Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling (2019) (0)
- The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis (2020) (0)
- Reference TROD : T 7 RNAi oligo designer (2017) (0)
- G.P.105 Preclinical evaluation of tamoxifen and other selective estrogen receptor modulators in mdx5Cv dystrophic mice (2014) (0)
- Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development (2018) (0)
- Signal transduction bysteroid hormones: nuclear localization isdifferentially regulated inestrogen andglucocorticoid receptors (1990) (0)
- HSP90 chaperone cycle for steroid hormone receptors (SHR) (2017) (0)
- A web application to manage a database for liquid nitrogen tanks (2004) (0)
- A Single Post-Translational Modification with Far-Reaching Effects on the Assembly of a Multiprotein Chaperone Complex: A Mechanistic View from the Integration of Computation and Experiments (2022) (0)
- S153: DECRYPTING THE ROLE OF HSP90Α AND Β ISOFORMS TO OVERCOME RESISTANCE IN BCR-ABL1 LEUKEMIA (2022) (0)
- The G Protein-Coupled Receptor GPR30 Mediates the Proliferative Effects Induced by 17 (cid:1) -Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells (2006) (0)
- Possibility of determining a rooting characteristic from a limited number of samples in root dynamics investigations on crops. (1977) (0)
- Root dynamics of Panicum maximum Jacq. 2. Annual rhythm of primary adventitious root formation and the development of the root mass for an intensively exploited prairie. (1977) (0)
- Rapport de mission en Chine (4-24 avril 1997) (1997) (0)
- Maize physiology and production. (1990) (0)
- Report on a visit to China (4-24 April 1997) (1997) (0)
- Dunbar: A study in second phase North Sea development (1994) (0)
- 17 beta -Estradiol, Genistein and 4-Hydroxytamoxifen induce proliferative effects in thyroid cancer cells via G protein couplet-receptor GPR30. (2006) (0)
- Method and apparatus for recovering a plane wrecks (1983) (0)
- The regional and territorial development, a multidisciplinary challenge (2014) (0)
- 100 and 50 years ago (1998) (0)
- Method and device for removal of crashed aircraft (1983) (0)
- An underground exploration of the endoscope type, in particular for the study of the plants rooting in situ (1984) (0)
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Didier Picard is affiliated with the following schools: