Didier Trono

Q: What Schools Are Affiliated With Didier Trono

Didier Trono is affiliated with the following schools: Central South University, École Polytechnique Fédérale de Lausanne, University of California, San Diego, Lund University, National Taiwan University, University of California, San Francisco, University of Geneva, Thomas Jefferson University

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Didier Trono

Biology

#3831

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#5807

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Genetics

#449

World Rank

#518

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Molecular Biology

#550

World Rank

#563

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biology Degrees

Didier Trono

Philosophy

#3948

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#6289

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#1878

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#2739

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Biology
Philosophy

Didier Trono's Degrees

PhD Molecular Biology University of Geneva
Doctorate Medicine University of Geneva

Why Is Didier Trono Influential?

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According to Wikipedia, Didier Trono is a Swiss virologist and a professor at the École Polytechnique Fédérale de Lausanne . He is known for his research on virus-host interactions and the development of lentiviral vectors for gene therapy.

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Didier Trono's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector (1996) (4939)
A Third-Generation Lentivirus Vector with a Conditional Packaging System (1998) (2975)
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo (1997) (2034)
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery (1998) (1853)
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. (1996) (1600)
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts (2003) (1538)
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. (2000) (1251)
Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors (1999) (1060)
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study (2020) (810)
Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference (2003) (763)
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector (1997) (744)
Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain (1994) (743)
KAP1 controls endogenous retroviruses in embryonic stem cells (2010) (633)
Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa (2010) (586)
ES cell potency fluctuates with endogenous retrovirus activity (2012) (535)
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. (1997) (525)
In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions (2011) (520)
Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells (1993) (495)
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis (1995) (407)
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase (1995) (390)
A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs (2013) (387)
A versatile tool for conditional gene expression and knockdown (2006) (387)
Molecular Criteria for Defining the Naive Human Pluripotent State (2016) (377)
Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: A molecular model for latency (1990) (358)
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner (1999) (356)
Inhibition of Hepatitis B Virus Replication by APOBEC3G (2004) (351)
KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks (2017) (346)
HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator (1995) (336)
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes (2000) (316)
HIV accessory proteins: Leading roles for the supporting cast (1995) (314)
The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. (1994) (314)
Nef-Induced CD4 Degradation A Diacidic-Based Motif in Nef Functions as a Lysosomal Targeting Signal through the Binding of β-COP in Endosomes (1999) (309)
KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading (2010) (309)
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. (2000) (304)
The Nef protein of HIV-1 associates with rafts and primes T cells for activation. (2000) (302)
Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates. (2002) (298)
Lentiviral vectors: turning a deadly foe into a therapeutic agent (2000) (295)
The plasma membrane as a combat zone in the HIV battlefield. (2000) (286)
HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals (2010) (282)
Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import (1996) (281)
HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus (1989) (279)
Production and Titration of Lentiviral Vectors (2006) (275)
A Single Amino Acid Determinant Governs the Species-specific Sensitivity of APOBEC3G to Vif Action* (2004) (269)
A family of double-homeodomain transcription factors regulates zygotic genome activation in placental mammals (2017) (267)
Statins Reduce Interleukin-6–Induced C-Reactive Protein in Human Hepatocytes: New Evidence for Direct Antiinflammatory Effects of Statins (2005) (261)
High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. (2000) (255)
Dynamic control of endogenous retroviruses during development. (2011) (251)
Nef-Induced CD4 and Major Histocompatibility Complex Class I (MHC-I) Down-Regulation Are Governed by Distinct Determinants: N-Terminal Alpha Helix and Proline Repeat of Nef Selectively Regulate MHC-I Trafficking (1999) (241)
Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. (2001) (240)
Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes (1998) (237)
A stable system for the high-titer production of multiply attenuated lentiviral vectors. (2000) (235)
Partial reverse transcripts in virions from human immunodeficiency and murine leukemia viruses (1992) (233)
KRAB zinc finger proteins (2017) (225)
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. (2003) (222)
Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression (1990) (221)
Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor β/δ (2006) (221)
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. (2005) (219)
The downregulation of CD4 and MHC‐I by primate lentiviruses: a paradigm for the modulation of cell surface receptors (1999) (211)
Production and titration of lentiviral vectors. (2006) (211)
APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS (2004) (208)
The developmental control of transposable elements and the evolution of higher species. (2015) (202)
Hide, shield and strike back: how HIV-infected cells avoid immune eradication (2003) (201)
MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant (2012) (186)
Evolutionally dynamic L1 regulation in embryonic stem cells (2014) (182)
Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues. (2016) (174)
Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization (2002) (172)
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. (1997) (170)
Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. (2000) (166)
Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies (2020) (162)
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs (2019) (162)
An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis (1988) (159)
In Vivo Protection of Nigral Dopamine Neurons by Lentiviral Gene Transfer of the Novel GDNF-Family Member Neublastin/Artemin (2000) (157)
Genomic instability in induced stem cells (2011) (153)
Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements (2014) (148)
Lentivirus-Mediated RNA Interference of DC-SIGN Expression Inhibits Human Immunodeficiency Virus Transmission from Dendritic Cells to T Cells (2004) (143)
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes (2019) (142)
Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency (1992) (138)
De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET (2013) (137)
Tuning silence: conditional systems for RNA interference (2006) (135)
Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes. (2002) (132)
Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer. (2000) (132)
Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G" (2004) (131)
The KRAB-ZFP/KAP1 system contributes to the early embryonic establishment of site-specific DNA methylation patterns maintained during development. (2012) (130)
IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes. (2003) (130)
KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress (2008) (129)
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells (2013) (129)
Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia. (2005) (128)
Characterization of human immunodeficiency virus type 1 Vif particle incorporation (1996) (122)
Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. (2000) (119)
DNA Damage Sensors ATM, ATR, DNA-PKcs, and PARP-1 Are Dispensable for Human Immunodeficiency Virus Type 1 Integration (2005) (119)
Contribution of Proteoglycans to Human Immunodeficiency Virus Type 1 Brain Invasion (2004) (118)
Report of the NIH Panel To Define Principles of Therapy of HIV Infection* (1998) (117)
Nef-mediated Clathrin-coated Pit Formation (1997) (117)
A human cell factor is essential for HIV‐1 Rev action. (1990) (116)
Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. (1999) (115)
The Krüppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis* (2007) (115)
Lentivirus Vector Gene Expression during ES Cell-Derived Hematopoietic Development In Vitro (2000) (114)
Modalities of Interleukin-7-Induced Human Immunodeficiency Virus Permissiveness in Quiescent T Lymphocytes (2002) (112)
The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation (2011) (112)
Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. (2006) (110)
Harnessing HIV for therapy, basic research and biotechnology. (2005) (109)
Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. (1988) (109)
Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation. (2009) (107)
ZNF445 is a primary regulator of genomic imprinting (2019) (105)
The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation* (2002) (100)
Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion (1999) (99)
Transepithelial transport of HIV-1 by M cells is receptor-mediated (2002) (99)
A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy (2013) (98)
Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. (1992) (97)
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch (2015) (97)
Applications of gene therapy to the CNS. (1996) (96)
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells (2014) (96)
Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide. (2002) (96)
The Nef protein of primate lentiviruses (1999) (95)
Lentiviral vectors, two decades later (2016) (94)
Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency (2014) (94)
Editing at the Crossroad of Innate and Adaptive Immunity (2005) (91)
Substitutions in the protease (3Cpro) gene of poliovirus can suppress a mutation in the 5' noncoding region (1990) (90)
DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells (2019) (88)
Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a duchenne myoblast cell line with long-term genotypic and phenotypic stability. (2003) (85)
Characterization of APOBEC3G binding to 7SL RNA (2008) (84)
Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. (1996) (83)
SMiLE-seq identifies binding motifs of single and dimeric transcription factors (2017) (82)
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix (1997) (80)
Efficient transduction of primary human B lymphocytes and nondividing myeloma B cells with HIV-1-derived lentiviral vectors. (2003) (79)
Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors (2001) (78)
Expression of FGF-2 in neural progenitor cells enhances their potential for cellular brain repair in the rodent cortex. (2007) (77)
Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities (2010) (76)
The Innate Antiretroviral Factor APOBEC3G Does Not Affect Human LINE-1 Retrotransposition in a Cell Culture Assay* (2004) (74)
Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina (2003) (74)
Measuring in vivo protein half-life. (2011) (72)
Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network (2014) (72)
A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy (2000) (70)
Repeated seroprevalence of anti-SARS-CoV-2 IgG antibodies in a population-based sample from Geneva, Switzerland (2020) (68)
Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. (2005) (68)
HIV-1 latency due to the site of proviral integration. (1993) (66)
Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes (2005) (65)
The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS (2000) (64)
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus. (2008) (63)
Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis. (2015) (61)
Production and Titration of Lentiviral Vectors (2007) (59)
A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (2015) (59)
Functional Analysis and Structural Modeling of Human APOBEC3G Reveal the Role of Evolutionarily Conserved Elements in the Inhibition of Human Immunodeficiency Virus Type 1 Infection and Alu Transposition (2009) (59)
Model Structure of Human APOBEC3G (2007) (58)
The Proteolytic Cleavage of Human Immunodeficiency Virus Type 1 Nef Does Not Correlate with Its Ability To Stimulate Virion Infectivity (1998) (58)
Entry and Transcription as Key Determinants of Differences in CD4 T-Cell Permissiveness to Human Immunodeficiency Virus Type 1 Infection (2004) (57)
Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19. (2005) (57)
Induction of Antiviral Cytidine Deaminases Does Not Explain the Inhibition of Hepatitis B Virus Replication by Interferons (2007) (56)
DUX is a non-essential synchronizer of zygotic genome activation (2019) (55)
The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification (2019) (55)
The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription (2006) (52)
Liver‐specific ablation of Krüppel‐associated box–associated protein 1 in mice leads to male‐predominant hepatosteatosis and development of liver adenoma (2012) (52)
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage (2020) (52)
ARF1 Regulates Nef-Induced CD4 Degradation (2004) (51)
Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription (2003) (51)
A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma (2021) (51)
Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats. (2005) (51)
Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach (2006) (51)
Global and Stage Specific Patterns of Krüppel-Associated-Box Zinc Finger Protein Gene Expression in Murine Early Embryonic Cells (2013) (50)
A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice. (2012) (50)
The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent (1993) (49)
KAP1 regulates gene networks controlling T‐cell development and responsiveness (2012) (49)
Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreaticβ -cells (2003) (48)
S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity (2021) (48)
Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease (2011) (48)
Genetic therapies for HIV infections: promise for the future. (1995) (47)
Seroprevalence of anti-SARS-CoV-2 antibodies after the second pandemic peak (2021) (47)
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function. (2012) (47)
Novel lentiviral vectors displaying "early-acting cytokines" selectively promote survival and transduction of NOD/SCID repopulating human hematopoietic stem cells. (2004) (46)
Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice (1997) (46)
Lentivirus Gene Transfer in Murine Hematopoietic Progenitor Cells Is Compromised by a Delay in Proviral Integration and Results in Transduction Mosaicism and Heterogeneous Gene Expression in Progeny Cells (2000) (45)
Differentiation of the RN33B Cell Line into Forebrain Projection Neurons after Transplantation into the Neonatal Rat Brain (2002) (44)
Lentivirus as a tool for lineage‐specific gene manipulations (2007) (44)
The Specificity of TRIM5α-Mediated Restriction Is Influenced by Its Coiled-Coil Domain (2010) (43)
The HIV Nef Protein Alters Ca2+ Signaling in Myelomonocytic Cells through SH3-mediated Protein-Protein Interactions* (1999) (42)
Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G (2013) (41)
The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units (2017) (41)
Ex Vivo Lentivirus Transduction and Immediate Transplantation of Uncultured Hepatocytes for Treating Hyperbilirubinemic Gunn Rat (2006) (40)
Lentiviral Vectors Interfering with Virus-Induced CD4 Down-Modulation Potently Block Human Immunodeficiency Virus Type 1 Replication in Primary Lymphocytes (2004) (39)
Picking the Right Spot (2003) (37)
The multifaceted role of HIV Nef. (1997) (37)
Insights into household transmission of SARS-CoV-2 from a population-based serological survey (2021) (36)
APOBEC3G-Depleted Resting CD4+ T Cells Remain Refractory to HIV1 Infection (2009) (35)
Lentiviral vectors and antiretroviral intrinsic immunity. (2005) (35)
Living in oblivion: HIV immune evasion. (2001) (35)
Human Immunodeficiency Virus Type 1 Matrix Protein Interacts with Cellular Protein HO3 (1998) (34)
Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α (2007) (34)
Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates. (2009) (34)
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients (2022) (33)
Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells (2018) (33)
Transduction of CD34+ cells with lentiviral vectors enables the production of large quantities of transgene‐expressing immature and mature dendritic cells (2001) (32)
Lentiviral‐mediated gene transfer into haematopoietic stem cells (2001) (32)
Genotypic Features of Lentivirus Transgenic Mice (2008) (31)
Inhibition of HIV‐1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping (2007) (31)
Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks. (2015) (30)
Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo (2010) (30)
Persistence of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance (2021) (30)
Risk of Reinfection After Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Population-based Propensity-score Matched Cohort Study (2021) (29)
A Systematic Enhancer Screen Using Lentivector Transgenesis Identifies Conserved and Non-Conserved Functional Elements at the Olig1 and Olig2 Locus (2010) (28)
Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages (2015) (28)
Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications (2009) (28)
Inhibition of HIV-1 in Cell Culture by Oligonucleotide-Loaded Nanoparticles (2001) (28)
A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing (2011) (28)
Lentivirus‐mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X‐CGD cells (2000) (28)
Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons (2019) (28)
Transduction of CpG DNA-stimulated primary human B cells with bicistronic lentivectors. (2005) (27)
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis (2018) (27)
Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements (1997) (26)
A highly potent antibody effective against SARS-CoV-2 variants of concern (2021) (26)
APOBEC3-Independent Interferon-Induced Viral Clearance in Hepatitis B Virus Transgenic Mice (2008) (26)
A Simple and Highly Effective Method for the Stable Transduction of Uncultured Porcine Hepatocytes Using Lentiviral Vector (2005) (26)
KAP1 facilitates reinstatement of heterochromatin after DNA replication (2018) (26)
Structural analysis of the Spike of the Omicron SARS-COV-2 variant by Cryo-EM and implications for immune evasion (2021) (26)
A Structure-function Analysis of the Nef Protein of Primate Lentiviruses (2000) (25)
When accessories turn out to be essential (1998) (25)
Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland (2021) (25)
ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer (2019) (24)
Ataxia-Telangiectasia-Mutated (ATM) Protein Can Enhance Human Immunodeficiency Virus Type 1 Replication by Stimulating Rev Function (2006) (24)
Drawing a fine line on endogenous retroelement activity (2015) (24)
VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. (2013) (23)
Virology. Picking the right spot. (2003) (23)
KRAB Can Repress Lentivirus Proviral Transcription Independently of Integration Site* (2006) (22)
Development and characterization of a triple combination gene therapy vector inhibiting HIV‐1 multiplication (2008) (22)
Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences (2011) (22)
Intracellular immunization: trans-dominant mutants of HIV gene products as tools for the study and interruption of viral replication. (1992) (21)
A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family. (2019) (20)
The Krüppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo * (2012) (20)
Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis. (1997) (19)
Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression (2020) (19)
Lentiviral vectors for the gene therapy of lympho-hematological disorders. (2002) (19)
Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis. (2004) (18)
Homology-based Identification of Capsid Determinants That Protect HIV1 from Human TRIM5α Restriction* (2010) (18)
Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain (2020) (17)
Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes (2019) (17)
TRIM 28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells (2013) (17)
Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences (1995) (17)
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development. (2021) (17)
HIV-1 Vpr and p21 restrict LINE-1 mobility (2018) (16)
Qualitative Changes in the SARS-CoV-2 Antibody Response in the Post-Infection Phase Impact the estimates of infections in Population-Based Seroprevalence Studies (2020) (15)
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys (2022) (15)
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma (2021) (15)
As time goes by: KRABs evolve to KAP endogenous retroelements. (2014) (14)
Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections (2020) (13)
Antiprion prophylaxis by gene transfer of a soluble prion antagonist. (2008) (13)
KAP1 is an antiparallel dimer with a functional asymmetry (2019) (13)
The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity (2020) (12)
Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. (2005) (11)
Ahead of the Curve: David Baltimore's Life in Science (2001) (11)
The evolution of gene expression and binding specificity of the largest transcription factor family in primates (2016) (11)
Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice (2017) (10)
HIV‐based vectors: getting the best out of the worst (2000) (10)
KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences (2022) (10)
Lentiviral Vector Mediated Transgenesis. (2011) (9)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors (2020) (9)
In Response to Freed et al (1997) (9)
Gene therapy: too much splice can spoil the dish. (2012) (8)
Persistence and detection of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance (2021) (8)
A human TRIM5α B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus (2008) (8)
DPPA 2 and DPPA 4 are necessary to establish a 2 C-like state in mouse embryonic stem cells (2019) (7)
Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study (2021) (7)
A multiplexed high-throughput neutralization assay reveals a lack of activity against multiple variants after SARS-CoV-2 infection (2021) (7)
Lentiviral vectors for the genetic modification of hematopoietic stem cells. (2001) (7)
SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties (2022) (6)
Molecular biology of HIV. (1994) (6)
KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity (2020) (6)
Design and Production of Human Immunodeficiency Virus-Derived Vectors (2006) (6)
[The application of lentiviral vectors for tissue-specific gene manipulations]. (2008) (6)
Primate-specific transposable elements shape transcriptional networks during human development (2022) (6)
P2G3 human monoclonal antibody neutralizes SARS-CoV-2 Omicron subvariants including BA.4 and BA.5 and Bebtelovimab escape mutants (2022) (6)
Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study (2022) (6)
Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression (2020) (6)
Profaning the ultimate sanctuary: HIV latency in hematopoietic stem cells. (2011) (5)
activating - surface-engineered lentiviral vectors that display a T cell Efficient gene transfer into human primary blood lymphocytes by (2013) (5)
Molecular biology and the development of AIDS therapeutics. (1996) (5)
A human-specific structural variation at the ZNF558 locus controls a gene regulatory network during forebrain development (2020) (5)
Nef and PAK: virulence factor and cellular accomplice. (1997) (5)
APOBEC 3 G-Depleted Resting CD 4 + T Cells Remain Refractory to HIV 1 Infection (2009) (4)
Production and Titration of Lentiviral (2007) (4)
A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression. (2016) (4)
A novel lentivector targets gene transfer into hHSC in marrow from patients with BM-failure-syndrome and in vivo in humanized mice (2011) (4)
Omicron infection induces low-level, narrow-range SARS-CoV-2 neutralizing activity (2022) (4)
Primate-specific cis- and trans-regulators shape transcriptional networks during human development (2021) (4)
KAP1 is an antiparallel dimer with a natively functional asymmetry (2019) (4)
Author response: Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch (2015) (4)
Drug-Free Remissions for HIV-Infected Individuals HIV Persistence and the Prospect of Long-Term (2010) (4)
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis (2022) (3)
Retroviruses under editing crossfire (2004) (3)
Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development (2022) (3)
De novo design of site-specific protein interactions with learned surface fingerprints (2023) (3)
Lentiviral Vectors (2002) (3)
ZFP 30 promotes adipogenesis through the KAP 1-mediated activation of a retrotransposon-derived Pparg 2 enhancer (2019) (3)
Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice". (2006) (3)
Innate immunity against retroviral pathogens: from an ambiguous genetic self to novel therapeutic approaches. (2009) (2)
Lentiviral Vectors for Gene Delivery in the Nervous System (1998) (2)
Perceptions of immunity and vaccination certificates among the general population of Geneva, Switzerland. (2021) (2)
In Vivo Protection of Nigral Dopamine Neurons by Lentiviral Gene Transfer of the Novel GDNF-Family Member Neublastin/Artemin Volume 15, Number 2 (2000), pages 199–214 (2001) (2)
Non-essential function of KRAB zinc finger gene clusters in retrotransposon suppression (2020) (2)
The KZFP/KAP1 system controls transposable elements-embedded regulatory sequences in adult T cells (2019) (2)
Statistical learning quantifies transposable element-mediated cis-regulation (2022) (1)
Author response: Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network (2014) (1)
Data from: Identification of ZEB1 as a central component of the adipogenic gene regulatory network (2014) (1)
DPPA2 and DPPA4 are necessary to establish a totipotent state in mouse embryonic stem cells (2018) (1)
Lymphocytes Virus Type 1 Replication in Primary Potently Block Human Immunodeficiency Virus-Induced CD 4 Down-Modulation Lentiviral Vectors Interfering with (2004) (1)
Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections (2022) (1)
Lentivirus as a tool for lineage‐specific gene manipulations (2007) (1)
De novo design of protein interactions with learned surface fingerprints (2023) (1)
Genetic Reactivation of Cone Photoreceptors Restores Complex Visual Responses in Retinitis pigmentosa - Part 1 (2010) (1)
[A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy]. (2014) (1)
Transactivating functions of human retroviruses: edited by I.S.Y. Chen, H. Koprowski, A. Srinivasan and P.K. Vogt Springer, 1995 DM178.00 hbk (viii + 239 pages) ISBN 3 540 57901 X (1996) (1)
Switzerland and the Digital Health Revolution. (2016) (1)
Ongoing evolution of KRAB zinc finger protein-coding genes in modern humans (2020) (1)
Apoptotic Change Is a Major Reason for Defect in Early Erythroid Development in Cell Line Models for Ribosomal Protein (RP) S19 Deficient Diamond-Blackfan Anemia. (2004) (1)
170. Ex vivo gene therapy of metabolic liver disorders using uncultured and lentivirally transduced hepatocytes (2004) (0)
InVivoGeneDelivery andStable Transduction of Nondividing Cells bya Lentiviral Vector (2016) (0)
Degree of hepatocytes differentiation and expression levels of liver specific transcription factors: influence of Hepatitis B Virus replication (2006) (0)
Genetic features and genomic targets of human KRAB-Zinc Finger Proteins (2023) (0)
Optirank: classification for RNA-Seq data with optimal ranking reference genes (2023) (0)
Lentiviral vectors mediated transgenesis (2011) (0)
Efficient and sensitive profiling of RNA-protein interactions using TLC-CLIP (2022) (0)
Getting in shape (1997) (0)
Lentiviral gene transfer into nod/scid repopulating cells results in monoclonal hematopoiesis with transduced myeloid and lymphoid progeny (2000) (0)
Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer (2021) (0)
ISOLATION AND CHARACTERIZATION OF MESENCHYMAL STEM CELLS FROM CULTURED HUMAN PANCREATIC ISLETS OF LANGERHANS (2006) (0)
Exploring the spatio-temporal transposcriptome of the developing human brain (2019) (0)
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range (2023) (0)
A KRABsody for Embryo-Placental Development. (2017) (0)
P1231 : Potential of induced pluripotent stem cells for the treatment of Crigler-Najjar liver disease (2015) (0)
Review Lentiviral Vectors and Antiretroviral Intrinsic Immunity (2005) (0)
900. Development of models for RPS19 deficient diamond-blackfan anemia using regulatable expression of siRNA against RPS19 (2004) (0)
Supplementary file 1. (2014) (0)
Transposable elements and their epigenetic control mechanisms are key regulators of transcriptional networks in pluripotent stem cells (2014) (0)
Compositions and systems for gene regulation (2003) (0)
Supplementary material from "KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity" (2020) (0)
TRIM 28 Represses Transc ription of Endogenous Retroviruses in Neural Progenitor Cells Graphical (2014) (0)
TREATMENT OF ACETAMINOPHEN-INDUCED FULMINANT LIVER FAILURE BY TRANSPLANTATION OF ENCAPSULATED IMMORTALIZED XENOGENEIC HEPATOCYTES (2004) (0)
Hematopoietic Mechanism in Diamond-Blackfan Anemia: Late Erythroid Development Is Not Affected by Ribosomal Protein S19 Deficiency. (2004) (0)
with Human Immunodeficiency Virus Type 1 Blocked Early-Stage Latency in the Peripheral Blood Cells of Certain Individuals Infected (2006) (0)
896. Complete and Permanent Correction of Hyperbilirubinemia in Newborn Gunn Rats by Lentiviral-Mediated Gene Transfer (2005) (0)
SARS-CoV-2 shifts transcription of host gene to increase Spike acylation and boost infectivity (2023) (0)
Expression in Progeny Cells Mosaicism and Heterogeneous Gene Integration and Results in Transduction Compromised by a Delay in Proviral Hematopoietic Progenitor Cells Is Lentivirus Gene Transfer in Murine (2000) (0)
HIV Gene Products as Manipulators of the Immune System (2001) (0)
KRAB zinc finger proteins ZNF587/ZNF417 protect lymphoma cells from replicative stress-induced inflammation (2023) (0)
Modulation of ATM gene expression in a murine mammary epithelial cell line (2000) (0)
The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer. (2023) (0)
Diamond-Blackfan anemia blocks erythroid development and mimics defects seen in Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA (2013) (0)
"Personalized health" : report to discuss options and frame for a new Swiss initiative (2014) (0)
Hominoid-Specific Transp osable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs Graphical (2019) (0)
Regulated lentiviral vector gene transfer for X-CGD (2012) (0)
A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig 1 and Olig 2 locus FRIEDLI (2017) (0)
O.110 Role of cellular differentiation for the efficiency of HBV replication (2006) (0)
derived lentiviral vectors - myeloma B cells with HIV-1 Efficient transduction of primary human B lymphocytes and nondividing (2013) (0)
Busskamp Responses in Retinitis Pigmentosa Genetic Reactivation of Cone Photoreceptors Restores Visual (2011) (0)
A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819 (2022) (0)
KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks (2018) (0)
PAX5 as a model to study the evolution of transcription factors' regulatory networks (2019) (0)
Compositions et systemes destines a la regulation genique (2003) (0)
Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants (2023) (0)
Improved chemeric glicoproteins and pseudotipated lentiviral vectors. (2003) (0)
Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells (2018) (0)
Additional file 3: of Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis (2018) (0)
ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer (2019) (0)
409. In Vivo Comparison of Liver-Specific Enhancer-Promoter Constructs in the Context of Lentiviral Vectors (2004) (0)
Author response: KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage (2020) (0)
Human APOBEC3G Dimerization and Cytosolic Solubility of Prototype Foamy Virus Bet Impairs the (2013) (0)
hematopoietic stem cells promote survival and transduction of NOD/SCID repopulating human Novel lentiviral vectors displaying ''early-acting cytokines'' selectively (2013) (0)
Procedes d'identification d'agents bloquant l'infection a vih (1995) (0)
[Didier Trono, dean of life sciences at the EPFL: "we want to give a twist to biomedical research"]. (2007) (0)
MHC-I Trafficking Proline Repeat of Nef Selectively Regulate Determinants : N-Terminal Alpha Helix and Down-Regulation Are Governed by Distinct Histocompatibility Complex Class I ( MHC-I ) Nef-Induced CD 4 and Major (1999) (0)
Collinearity in Mouse Limbs Genes HoxD A Switch Between Topological Domains Underlies (2014) (0)
895. Ex Vivo Gene Therapy of Metabolic Liver Disorders Using Uncultured and Lentivirally Transduced Hepatocytes (2005) (0)
Cell uptake and cell release assay Cells were treated with a panel of active transport inhibitors at the following concentrations: Dynasore (62.5μM), a dynamin inhibitor (2017) (0)
and Efficient In Vivo Gene Delivery Self-Inactivating Lentivirus Vector for Safe (2013) (0)
Table S1 - TF_screen (2014) (0)
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes (2020) (0)
A KRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy (2016) (0)
Control of mitophagie by microRNAs - A key step of erythropoiesis (2014) (0)
11-P005 Fluorescence-based promoter gene trap screen during mouse pre-implantation development (2009) (0)
Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modiﬁcations (cid:1) (2009) (0)
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis (2018) (0)
KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences (2022) (0)
Abstract 2853: Transposon-activatedPOU5F1Bpromotes colorectal cancer growth and metastasis (2021) (0)
Document S1. Six Figures, Supplemental Experimental Procedures, and Supplemental References (2012) (0)

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