Dinah Singer
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American immunologist
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Why Is Dinah Singer Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dinah Schiffer Singer is an American immunologist specialized in the regulation of transcription in cancer, gene expression, and molecular immunology. She is the deputy director for scientific strategy and development at the National Cancer Institute . Singer was previously director of the NCI division of cancer biology from 1999 to 2019.
Dinah Singer's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A community effort to assess and improve drug sensitivity prediction algorithms (2014) (468)
- BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain (2012) (319)
- A community computational challenge to predict the activity of pairs of compounds (2014) (244)
- BRD4 is a Histone Acetyltransferase that Evicts Nucleosomes from Chromatin (2016) (242)
- Repression of MHC class I gene promoter activity by two-exon Tat of HIV. (1993) (239)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. (1999) (205)
- Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. (2013) (198)
- RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription (2016) (187)
- HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes. (1998) (148)
- Autoregulation of thyroid-specific gene transcription by thyroglobulin. (1998) (146)
- Core promoters in transcription: old problem, new insights. (2015) (110)
- Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus. (1993) (107)
- A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. (1997) (91)
- CIITA and Its Dual Roles in MHC Gene Transcription (2013) (86)
- Thymosin‐α1 regulates MHC class I expression in FRTL‐5 cells at transcriptional level (2000) (84)
- Characterization of a porcine genomic clone encoding a major histocompatibility antigen: expression in mouse L cells. (1982) (84)
- Bromodomain 4: a cellular Swiss army knife (2016) (70)
- BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses (2019) (66)
- Identification and DNA sequence of an interspersed repetitive DNA element in the genome of the miniature swine. (1987) (65)
- Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4 (1990) (64)
- Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. (1985) (63)
- Role of MHC class I molecules in autoimmune disease. (1997) (63)
- A complex regulatory DNA element associated with a major histocompatibility complex class I gene consists of both a silencer and an enhancer (1991) (61)
- Structure and expression of two porcine genomic clones encoding class I MHC antigens. (1985) (61)
- Regulation of Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells (1997) (59)
- Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene (1988) (58)
- HIV Tat represses transcription through Sp1-like elements in the basal promoter. (1995) (55)
- MYC protein stability is negatively regulated by BRD4 (2020) (55)
- Cross-talk Among RNA Polymerase II Kinases Modulates C-terminal Domain Phosphorylation* (2012) (50)
- TAFII55 binding to TAFII250 inhibits its acetyltransferase activity (2001) (49)
- A U.S. “Cancer Moonshot” to accelerate cancer research (2016) (49)
- Hiv Tat represses transcription of the β2-microglobulin promoter (1998) (48)
- Methimazole prevents induction of experimental systemic lupus erythematosus in mice. (1994) (48)
- Two faces of BRD4 (2013) (47)
- Studies on the interaction of H1 histone with superhelical DNA: characterization of the recognition and binding regions of H1 histones. (1976) (46)
- Elf-1 regulates basal expression from the T cell antigen receptor zeta-chain gene promoter. (1998) (46)
- Ethanol: an enhancer of major histocompatibility complex antigen expression (1987) (45)
- Tissue-specific expression and structure of a divergent member of a class I MHC gene family. (1987) (43)
- Report on EU–USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008) (2009) (43)
- TAF7: a possible transcription initiation check-point regulator. (2006) (43)
- Distinct Transcriptional Pathways Regulate Basal and Activated Major Histocompatibility Complex Class I Expression (2003) (41)
- TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb (2008) (41)
- The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells (2012) (41)
- The GTP-Binding Domain of Class II Transactivator Regulates Its Nuclear Export (2003) (40)
- Structure and expression of class I MHC genes in the miniature swine. (1987) (39)
- Arrangement of a highly repeated DNA sequence in the genome and chromatin of the African green monkey. (1979) (38)
- Upstream Stimulatory Factor Regulates Major Histocompatibility Complex Class I Gene Expression: the U2ΔE4 Splice Variant Abrogates E-Box Activity (1999) (38)
- Graves’ Disease: A Host Defense Mechanism Gone Awry (2000) (37)
- Periocular inflammation in mice with experimental systemic lupus erythematosus. A new experimental blepharitis and its modulation. (1995) (37)
- Active Repression of Major Histocompatibility Complex Class I Genes in a Human Neuroblastoma Cell Line* (1996) (37)
- Expression of nonclassical MHC class Ib genes (2003) (36)
- A Blueprint for Characterizing Senescence (2020) (35)
- ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis1 (2009) (30)
- HIV Tat represses transcription of the beta 2-microglobulin promoter. (1998) (28)
- H5 Histone and DNA-relaxing enzyme of chicken erythrocytes. Interaction with superhelical DNA. (1976) (28)
- MHC class I expression regulates susceptibility to spontaneous autoimmune disease in (NZBxNZW)F1 mice (2005) (27)
- The Tumor Microenvironment at a Turning Point Knowledge Gained Over the Last Decade, and Challenges and Opportunities Ahead: A White Paper from the NCI TME Network. (2017) (26)
- ATG deserts define a novel core promoter subclass. (2005) (26)
- Beta-chain gene rearrangements and V beta gene usage in DPw2-specific T cells. (1987) (25)
- A T Lymphocyte-Specific Transcription Complex Containing RUNX1 Activates MHC Class I Expression (2005) (25)
- Expression of a class I MHC transgene: regulation by a tissue-specific negative regulatory DNA sequence element. (1990) (25)
- Inverse correlation between steady‐state RNA and cell surface T cell receptor levels (1990) (25)
- Major Histocompatibility Class II HLA-DRα Gene Expression in Thyrocytes: Counter Regulation by the Class II Transactivator and the Thyroid Y Box Protein. (1998) (24)
- The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing. (2019) (24)
- TAFII250-independent Transcription Can Be Conferred on a TAFII250-dependent Basal Promoter by Upstream Activators* (2000) (24)
- The 90K protein increases major histocompatibility complex class I expression and is regulated by hormones, gamma-interferon, and double-strand polynucleotides. (2004) (24)
- Differential context-specific impact of individual core promoter elements on transcriptional dynamics (2017) (22)
- Cancer Molecular Analysis Project: weaving a rich cancer research tapestry. (2002) (21)
- Novel Functions for TAF7, a Regulator of TAF1-independent Transcription (2010) (21)
- Measure of Transient Transfection Efficiency Using β-Galactosidase Protein (1997) (21)
- Effect of mouse interferon on the expression of a porcine major histocompatibility gene introduced into mouse L cells. (1984) (21)
- HIV Tat protein requirements for transactivation and repression of transcription are separable. (1998) (21)
- Characterization of complexes of superhelical and relaxed closed circular DNA with H1 and phosphorylated H1 histones. (1978) (20)
- Ethanol: an enhancer of transplantation antigen expression. (1989) (20)
- Characterization of a new subfamily of class I genes in the H-2 complex of the mouse (1988) (20)
- In vivo function of regulatory DNA sequence elements of a major histocompatibility complex class I gene (1992) (19)
- Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus (1999) (19)
- Histone Modifications, but Not Nucleosomal Positioning, Correlate with Major Histocompatibility Complex Class I Promoter Activity in Different Tissues In Vivo (2008) (18)
- TAF7: traffic controller in transcription initiation. (2013) (17)
- Evidence of increased class I MHC expression on human peripheral blood lymphocytes during acute ethanol intoxication. (1988) (17)
- Cytotoxic T lymphocyte recognition of a xenogeneic major histocompatibility complex antigen expressed in transgenic mice (1987) (17)
- Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation (2018) (17)
- Regulation of MHC Class I Expression by Foxp3 and Its Effect on Regulatory T Cell Function (2014) (16)
- Spontaneous Autoimmune Disease in (NZB × NZW)F1 Mice is Ameliorated by Treatment with Methimazole (1998) (16)
- Three Novel Downstream Promoter Elements Regulate MHC Class I Promoter Activity in Mammalian Cells (2010) (16)
- Striking similarities between the regulatory mechanisms governing yeast mating-type genes and mammalian major histocompatibility complex genes (1991) (15)
- Meeting report: NCI think tanks in cancer biology. (2005) (15)
- Class I major histocompatibility complex genes in vertebrate species: What is the common denominator? (1987) (14)
- Regulation of Major Histocompatibility (MHC) Class II Human Leukocyte Antigen-DRα Gene Expression in Thyrocytes by Single Strand Binding Protein-1, a Transcription Factor That Also Regulates Thyrotropin Receptor and MHC Class I Gene Expression. (1998) (14)
- High Glucose Levels Increase Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells and Amplify Interferon-γ Action. (2002) (14)
- Specific association of repetitive DNA sequences with major histocompatibility genes (1983) (14)
- Characterization of two class I genes from the H2-M region: evidence for a new subfamily (1998) (14)
- Highly repeated DNA of the baboon: organization of sequences homologous to highly repeated DNA of the African green monkey. (1979) (13)
- Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity. (2013) (12)
- Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole. (2010) (11)
- Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells (1983) (11)
- Measure of transient transfection efficiency using beta-galactosidase protein. (1997) (10)
- Extensive interactions between HIV TAT and TAF(II)250. (2001) (10)
- Major Histocompatibility Complex Class I Core Promoter Elements Are Not Essential for Transcription in vivo (2013) (9)
- Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (Mac-2BP) protein. (2007) (9)
- Progress and potential: the Cancer Moonshot. (2021) (9)
- Major histocompatibility class II HLA-DR alpha gene expression in thyrocytes: counter regulation by the class II transactivator and the thyroid Y box protein. (1998) (8)
- Implementing the Cancer Moonshot and beyond. (2017) (8)
- Novel Functions for TAF 7 , a Regulator of TAF 1-independent Transcription (2010) (7)
- Expression of a class I MHC transgene: effects of in vivo α/β-interferon treatment (2006) (7)
- The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains (2021) (7)
- Identification of regulatory elements associated with a class I MHC gene. (1988) (7)
- Assay of an intrinsic acetyltransferase activity of the transcriptional coactivator CIITA. (2003) (7)
- NCI’s Work to Advance Cancer Research while Responding to the COVID-19 Pandemic (2020) (6)
- TAF 7 : A possible transcription initiation checkpoint regulator (2006) (5)
- TAF7 (2013) (5)
- In Vivo Expression of MHC Class I Genes Depends on the Presence of a Downstream Barrier Element (2009) (5)
- Mouse Models of Human Cancer Web-Based Resources (2003) (5)
- The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis (2021) (4)
- Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction* (2015) (4)
- High glucose levels increase major histocompatibility complex class I gene expression in thyroid cells and amplify interferon-gamma action. (2002) (4)
- Cancer moonshot countdown (2016) (4)
- A new phase of the Cancer Moonshot to end cancer as we know it (2022) (4)
- Regulation of major histocompatibility (MHC) class II human leukocyte antigen-DR alpha gene expression in thyrocytes by single strand binding protein-1, a transcription factor that also regulates thyrotropin receptor and MHC class I gene expression. (1998) (3)
- Erratum: BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin (2017) (3)
- BET Bromodomain Inhibitors Target the NEUROD1-subtype SCLC by Blocking NEUROD1 Transactivation (2021) (2)
- Modulation of experimental systemic lupus erythematosus. (1996) (2)
- BET Inhibitors Target the SCLC-N subtype Small Cell Lung Cancer by Blocking NEUROD1 Transactivation (2022) (1)
- Immature CD 8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation , Selectively Dependent on BRD 4 for Their Differentiation (2018) (1)
- Regulation of expression of a class I MHC transgene. (1991) (1)
- Repression of the nonclassicalMHC class I geneH2-M1 bycis-acting silencer DNA elements (1996) (1)
- Regulation of expression of a class I major histocompatibility complex transgene. (1990) (1)
- Bromodomain Protein, BRD4, Contributes to the Regulation of Alternative Splicing (2018) (1)
- Neuroblastoma differentiation is regulated by cooperation of the RET and TRKA signaling pathways (2004) (1)
- Expression of a Non-Classical Class I Gene in Transgenic Mice (1990) (0)
- Faculty Opinions recommendation of MicroRNAs modulate hematopoietic lineage differentiation. (2004) (0)
- Transactivator Regulates Its Nuclear Export The GTP-Binding Domain of Class II (2002) (0)
- Core promoter elements are not essential for transcription in mammals (2013) (0)
- Faculty Opinions recommendation of Control of transcription by cell size. (2010) (0)
- Class I Expression Complex Containing RUNX 1 Activates MHC A T Lymphocyte-Specific Transcription (2005) (0)
- Harnessing the Power of Discovery. (2023) (0)
- Faculty Opinions recommendation of DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. (2008) (0)
- Editorial: BET proteins in chromatin architecture, transcription and disease (2022) (0)
- Director's update: The Tumor Microenvironment: Providing Important Clues to Metastasis (2004) (0)
- BRD4 Deficiency Selectively Affects a Unique Developmental Subpopulation in Thymocytes (2018) (0)
- TAF7 is essential for early embryonic mouse development (2011) (0)
- Faculty Opinions recommendation of Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. (2009) (0)
- Differential Expression ofPorcine MajorHistocompatibili ty DNA Sequences Introduced into MouseL Cells (2006) (0)
- Faculty Opinions recommendation of Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. (2003) (0)
- Regulation of Class I MHC Expression: In Vivo Function of Regulatory DNA Sequence Elements in Transgenic Mice (1990) (0)
- Elucidating the structure and function of the nucleus-The NIH Common Fund 4D Nucleome program. (2023) (0)
- Faculty Opinions recommendation of Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter. (2001) (0)
- Faculty Opinions recommendation of RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. (2011) (0)
- Faculty Opinions recommendation of The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. (2005) (0)
- Core promoter elements are not essential for transcription in mammals (2013) (0)
- Faculty Opinions recommendation of Induction and suppression of RNA silencing by an animal virus. (2002) (0)
- Characterization of a porcine geno histocompatibility antigen: Express (cloning/transplantation/transfection/cytotoxicity/immunoprecipit (2016) (0)
- A ComplexRegulatory DNA ElementAssociated witha Major Histocompatibility ComplexClassIGeneConsists of (1991) (0)
- Cohesin regulates alternative splicing (2023) (0)
- Transgenerational Epigenetic Inheritance of MHC Class I Gene Expression is Regulated by the CCAAT Promoter Element (2023) (0)
- Faculty Opinions recommendation of Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. (2012) (0)
- Faculty of 1000 evaluation for MicroRNAs modulate hematopoietic lineage differentiation. (2004) (0)
- Foxp3 is pro-apoptotic and responsible for the cytokine dependence of regulatory T cells (2012) (0)
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