Ding-Shinn Chen
Taiwanese hepatologist
Ding-Shinn Chen's AcademicInfluence.com Rankings

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Philosophy
Ding-Shinn Chen's Degrees
- Doctorate Medicine National Taiwan University
- PhD Medicine National Taiwan University
Why Is Ding-Shinn Chen Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ding-Shinn Chen was a Taiwanese hepatologist. He was born on 6 July 1943, in what became Yingge District, New Taipei City. Chen's mother became sick when he was a child, and needed surgical intervention. As such, Chen was around medical professionals at a young age, which sparked his interest in the field. Upon high school graduation, Chen was accepted into the National Taiwan University College of Medicine. During his fourth year of medical school, Chen's father died of liver cancer, inspiring him to study hepatology. He completed medical studies in 1968. Chen became a resident at National Taiwan University Hospital and later joined the NTU medical faculty, working closely with . Chen and Sung advocated for widespread preventative measures against hepatitis B, resulting in the establishment of a mass vaccination program in 1984. Chen specialized in liver disease research, namely hepatitis. His research earned Chen the nickname Liver King , which, pronounced in Mandarin, is homophonous to Gandhi.
Ding-Shinn Chen's Published Works
Published Works
- Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. (1997) (1731)
- Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update (2015) (1728)
- Hepatitis B e antigen and the risk of hepatocellular carcinoma. (2002) (1243)
- A proposed system for the nomenclature of hepatitis C viral genotypes (1994) (1100)
- Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. (2018) (1034)
- Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. (2000) (951)
- Global control of hepatitis B virus infection. (2002) (796)
- Statements from the Taormina expert meeting on occult hepatitis B virus infection. (2008) (784)
- Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma (2008) (566)
- Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. (2005) (563)
- Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study. (2009) (537)
- Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. (2003) (529)
- Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. (2008) (514)
- Hepatitis B genotypes and the response to interferon therapy. (2000) (492)
- High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. (2012) (464)
- Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications. (1985) (421)
- Seroepidemiology of hepatitis B virus infection in children: Ten years of mass vaccination in Taiwan. (1996) (357)
- Hepatitis B Virus Infection in Children and Adolescents in a Hyperendemic Area: 15 Years after Mass Hepatitis B Vaccination (2001) (355)
- The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo (2014) (345)
- From hepatitis to hepatoma: lessons from type B viral hepatitis. (1993) (334)
- Hepatitis C virus infection in an area hyperendemic for hepatitis B and chronic liver disease: the Taiwan experience. (1990) (333)
- Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies. (2007) (322)
- A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. (1987) (320)
- Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. (1992) (311)
- Hepatitis B virus infection (2018) (302)
- The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus. (1991) (294)
- Update of the statements on biology and clinical impact of occult hepatitis b virus infection. (2019) (285)
- High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. (2006) (271)
- MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells. (2009) (257)
- An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection (2006) (252)
- Long-term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C. (1996) (250)
- Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B. (2009) (232)
- Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads (2013) (230)
- Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission (2019) (227)
- Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother‐to‐infant transmission of hepatitis B virus (2015) (212)
- Genotypes and Clinical Phenotypes of Hepatitis B Virus in Patients with Chronic Hepatitis B Virus Infection (2002) (212)
- Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. (2004) (211)
- Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. (2009) (211)
- Early detection of hepatocellular carcinoma by real‐time ultrasonography. A prospective study (1985) (206)
- Percutaneous Ethanol Injection Versus Surgical Resection for the Treatment of Small Hepatocellular Carcinoma: A Prospective Study (2005) (203)
- Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma. (2004) (203)
- Strategies to control hepatitis B: Public policy, epidemiology, vaccine and drugs. (2015) (200)
- Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters. (2011) (197)
- Epidemiologic Features of Kawasaki Disease in Taiwan, 1996–2002 (2004) (196)
- Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: A study just before mass hepatitis B vaccination program in Taiwan (1986) (195)
- Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial. (2008) (194)
- Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells. (1992) (194)
- Serum alpha-fetoprotein in the early stage of human hepatocellular carcinoma. (1984) (194)
- Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. (2000) (191)
- The Taiwanese hepatitis C virus genome: sequence determination and mapping the 5' termini of viral genomic and antigenomic RNA. (1992) (186)
- Minimization of hepatitis B infection by a 25-year universal vaccination program. (2012) (180)
- Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. (2006) (178)
- Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention. (2013) (174)
- Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers. (1995) (173)
- Occult Hepatitis B Virus Infection and Clinical Outcomes of Patients with Chronic Hepatitis C (2002) (171)
- A prospective study of transfusion-transmitted GB virus C infection: similar frequency but different clinical presentation compared with hepatitis C virus. (1996) (167)
- Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers (2004) (165)
- Interferon-ribavirin for chronic hepatitis C with and without cirrhosis: analysis of individual patient data of six controlled trials. Eurohep Study Group for Viral Hepatitis. (1999) (163)
- Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer. (2016) (161)
- Possible role of high-titer maternal viremia in perinatal transmission of hepatitis C virus. (1994) (159)
- Prevention of Hepatocellular Carcinoma by Universal Vaccination against Hepatitis B Virus: The Effect and Problems (2005) (158)
- Surgical treatment of 109 patients with symptomatic and asymptomatic hepatocellular carcinoma. (1986) (158)
- Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota (2015) (156)
- Serum alphafetoprotein in hepatocellular carcinoma (1977) (156)
- Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization. (2008) (154)
- Identification of androgen response elements in the enhancer I of hepatitis B virus: A mechanism for sex disparity in chronic hepatitis B (2009) (153)
- Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication* (2009) (150)
- Ultrasound-guided cutting biopsy for the diagnosis of hepatocellular carcinoma--a study based on 420 patients. (1996) (149)
- Intrafamilial transmission of hepatitis C virus: the important role of infections between spouses. (1992) (149)
- Detection of hepatitis B virus DNA by polymerase chain reaction in plasma of volunteer blood donors negative for hepatitis B surface antigen. (1991) (148)
- Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma. (2004) (147)
- Long-term immunogenicity and efficacy of universal hepatitis B virus vaccination in Taiwan. (2003) (146)
- The significance of spontaneous hepatitis B e antigen seroconversion in childhood: With special emphasis on the clearance of hepatitis B e antigen before 3 years of age (1995) (146)
- Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data (2011) (137)
- Prognostic histologic features of resected small hepatocellular carcinoma (HCC) in Taiwan. A comparison with resected large HCC (1985) (137)
- Small hepatocellular carcinoma--a clinicopathological study in thirteen patients. (1982) (137)
- Production of hepatitis delta virus and suppression of helper hepatitis B virus in a human hepatoma cell line (1991) (136)
- Determinants of spontaneous surface antigen loss in hepatitis B e antigen–negative patients with a low viral load (2012) (135)
- Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level (2007) (135)
- Therapeutic implications of hepatitis B virus genotypes (2005) (134)
- Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. (2006) (133)
- Interaction of hepatitis B virus, chemical carcinogen, and genetic susceptibility: Multistage hepatocarcinogenesis with multifactorial etiology (2002) (133)
- Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas. (1994) (132)
- Ribavirin and interferon is effective for hepatitis C virus clearance in hepatitis B and C dually infected patients (2003) (131)
- Cellular Immune Response to HBcAg in Mother‐to‐Infant Transmission of Hepatitis B Virus (1992) (131)
- Secular trends and geographic variations of hepatitis B virus and hepatitis C virus‐associated hepatocellular carcinoma in Taiwan (2006) (130)
- Effects of anticoagulants and storage of blood samples on efficacy of the polymerase chain reaction assay for hepatitis C virus (1992) (130)
- Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: molecular epidemiology and genome evolution. (2004) (129)
- Biologic and prognostic significance of hepatocyte hepatitis B core antigen expressions in the natural course of chronic hepatitis B virus infection. (1987) (128)
- Clonal origin of recurrent hepatocellular carcinomas. (1989) (123)
- Epidemiology of HBV infection in Asian blood donors: emphasis on occult HBV infection and the role of NAT. (2006) (122)
- Changing disease burden of hepatocellular carcinoma in the Far East and Southeast Asia (2005) (121)
- Activation of protooncogene c-jun by the X protein of hepatitis B virus. (1993) (118)
- Seroepidemiologic survey for hepatitis B virus infection in Taiwan: the effect of hepatitis B mass immunization. (1999) (116)
- Hepatitis B viral factors in HBeAg‐Negative carriers with persistently normal serum alanine aminotransferase levels (2007) (116)
- Ultrasonography of small hepatic tumors using high-resolution linear-array real-time instruments. (1984) (115)
- Transplacental leakage ofHBeAg-positive maternal blood as the most likely route in causing intrauterine infection with hepatitis B virus (1987) (115)
- High hepatitis C viral load is associated with insulin resistance in patients with chronic hepatitis C (2007) (115)
- Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan. (2006) (113)
- Liver Resection Improves the Survival of Patients with Multiple Hepatocellular Carcinomas (2009) (112)
- RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant (2005) (110)
- Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination (2004) (109)
- Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma (1989) (108)
- Hepatitis B viral genotypes and lamivudine resistance. (2002) (107)
- Small-form hepatitis B surface antigen is sufficient to help in the assembly of hepatitis delta virus-like particles (1991) (107)
- Hepatitis B Virus Infection, Its Sequelae, and Prevention in Taiwan (1987) (106)
- Tumor invasiveness and prognosis in resected hepatocellular carcinoma. Clinical and pathogenetic implications (1988) (106)
- Increased risk of cirrhosis and its decompensation in chronic hepatitis C patients with new‐onset diabetes: A nationwide cohort study (2014) (105)
- Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan. (2001) (104)
- Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV‐related hepatocellular carcinoma using a proteomics approach (2006) (102)
- Factors affecting clearance of hepatitis B e antigen in hepatitis B surface antigen carrier children. (1989) (102)
- Determination of immune memory to hepatitis B vaccination through early booster response in college students (2010) (100)
- Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma. (2001) (100)
- Hepatitis B virus infection and chronic liver disease in Taiwan. (1978) (99)
- Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α. (2012) (99)
- Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers (2014) (98)
- Small hepatocellular carcinoma: intratumor ethanol treatment using new needle and guidance systems. (1987) (98)
- Pegylated Interferon-α2a With or Without Low-Dose Ribavirin for Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Receiving Hemodialysis (2013) (97)
- Seroprevalence of hepatitis B virus infection in children in Taipei, 1989: Five years after a mass hepatitis B vaccination program (1991) (95)
- Superinfection of heterologous hepatitis C virus in a patient with chronic type C hepatitis. (1993) (95)
- Hepatocellular carcinoma in Taiwan (2007) (95)
- Association of chronic hepatitis B virus infection with insulin resistance and hepatic steatosis (2008) (95)
- Clinical and Virological Aspects of Blood Donors Infected with Hepatitis B Virus Genotypes B and C (2002) (95)
- Efficacy of a Mass Hepatitis B Vaccination Program in Taiwan: Studies on 3464 Infants of Hepatitis B Surface Antigen—Carrier Mothers (1988) (95)
- Plasma des‐γ‐carboxyprothrombin in the early stage of hepatocellular carcinoma (1990) (94)
- Transmission of hepatitis C virus between spouses: the important role of exposure duration. (1996) (94)
- Clinical and microbiological features of liver abscess after transarterial embolization for hepatocellular carcinoma. (1997) (93)
- Surgical resection for recurrent hepatocellular carcinoma: prognosis and analysis of risk factors. (1996) (93)
- Androgen pathway stimulates MicroRNA‐216a transcription to suppress the tumor suppressor in lung cancer‐1 gene in early hepatocarcinogenesis (2012) (93)
- Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: association with elevated alpha-fetoprotein production. (1996) (92)
- Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c‐Src and glycogen synthase kinase‐3β kinase pathways (2009) (92)
- Epidemiological Study on Hepatitis B Virus infection in Taiwan (1984) (91)
- δ Agent Infection in Patients with Chronic Liver Diseases and Hepatocellular Carcinoma‐An Infrequent Finding in Taiwan (1984) (91)
- Statins Reduce the Risk of Cirrhosis and Its Decompensation in Chronic Hepatitis B Patients: A Nationwide Cohort Study (2016) (91)
- Acute exacerbations of chronic hepatitis B are rarely associated with superinfection of hepatitis B virus (2001) (90)
- Fibrosing cholestatic hepatitis in a hepatitis B surface antigen carrier after renal transplantation. (1994) (89)
- OncoDB.HCC: an integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci (2006) (88)
- Serum hepatitis B surface antigen concentration correlates with HBV DNA level in patients with chronic hepatitis B (2010) (88)
- Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus (1989) (87)
- Childhood hepatocellular carcinoma develops exclusively in hepatitis B surface antigen carriers in three decades in Taiwan. Report of 51 cases strongly associated with rapid development of liver cirrhosis. (1987) (86)
- Transfusion‐transmitted HBV infection in an endemic area: the necessity of more sensitive screening for HBV carriers (2002) (86)
- Association of pre‐S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma (2007) (86)
- Effect of Host and Viral Factors on Hepatitis B E Antigen-Positive Chronic Hepatitis B Patients Receiving Pegylated Interferon-α-2A Therapy (2011) (85)
- Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects. (2010) (85)
- Transmission of hepatitis C virus in Asia: past and present perspectives (2000) (84)
- GBV-C in the aetiology of fulminant hepatitis (1996) (84)
- Toward elimination and eradication of hepatitis B (2010) (83)
- Distinct Hepatitis B Virus Dynamics in the Immunotolerant and Early Immunoclearance Phases (2010) (82)
- Spontaneous loss of HBsAg in children with chronic hepatitis B virus infection (1992) (81)
- Increased risk of cirrhosis and its decompensation in chronic hepatitis B patients with newly diagnosed diabetes: a nationwide cohort study. (2013) (81)
- Basal core‐promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen‐negative chronic hepatitis B (2005) (78)
- Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected HepG2 cells (1991) (77)
- Hepatitis C virus RNA in saliva of patients with posttransfusion hepatitis and low efficiency of transmission among spouses (1992) (77)
- Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. (2005) (77)
- Natural history of chronic hepatitis B virus infection: New light on an old story (1993) (76)
- Hepatitis B virus integration in hepatitis B virus‐related hepatocellular carcinoma in childhood (1991) (76)
- High Level of Hepatitis B Core-related Antigen Associated With Increased Risk of Hepatocellular Carcinoma in Patients With Chronic HBV Infection of Intermediate Viral Load. (2019) (76)
- Safety and immunogenicity of hepatitis A vaccine in healthy children. (1993) (74)
- Transient elastography to assess hepatic fibrosis in hemodialysis chronic hepatitis C patients. (2011) (74)
- Applicability of staging systems for patients with hepatocellular carcinoma is dependent on treatment method--analysis of 2010 Taiwanese patients. (2009) (74)
- Hepatitis B virus infection and hepatocellular carcinoma: molecular genetics and clinical perspectives. (1999) (74)
- Isoprenylation of large hepatitis delta antigen is necessary but not sufficient for hepatitis delta virus assembly. (1994) (74)
- Fulminant hepatitis in children in Taiwan: the important role of hepatitis B virus. (1987) (73)
- Serum hepatitis B virus DNA in healthy HBsAg‐negative Chinese adults evaluated by polymerase chain reaction (1990) (73)
- Mixed infections of hepatitis C virus as a factor in acute exacerbations of chronic type C hepatitis. (1994) (73)
- A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation. (2003) (73)
- GB virus-C/hepatitis G virus infection in an area endemic for viral hepatitis, chronic liver disease, and liver cancer. (1997) (73)
- Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children (1990) (73)
- Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. (2007) (70)
- Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase (2001) (70)
- Transplacental leakage of HBeAg-positive maternal blood as the most likely route in causing intrauterine infection with hepatitis B virus. (1987) (70)
- Slow decline of hepatitis B burden in general population: Results from a population-based survey and longitudinal follow-up study in Taiwan. (2015) (70)
- Hepatitis B- and C-related hepatocellular carcinomas yield different clinical features and prognosis. (2006) (69)
- Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy (2011) (68)
- Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model (2010) (68)
- Postpartum subsidence of hepatitis B viral replication in hbeag‐positive carrier mothers (1989) (67)
- Low incidence of hepatitis C virus transmission between spouses: A prospective study (2000) (67)
- Noninvasive tests for the prediction of significant hepatic fibrosis in hepatitis C virus carriers with persistently normal alanine aminotransferases (2006) (67)
- Least Microtransfusion From Mother to Fetus in Elective Cesarean Delivery (1996) (67)
- Sustained hepatitis C virus clearance and increased hepatitis B surface antigen seroclearance in patients with dual chronic hepatitis C and B during posttreatment follow‐up (2013) (66)
- Secular trend of age‐specific prevalence of hepatitis B surface and e antigenemia in pregnant women in Taiwan (2003) (66)
- Functional study of hepatitis delta virus large antigen in packaging and replication inhibition: role of the amino-terminal leucine zipper (1992) (66)
- Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study (2002) (66)
- Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients (2012) (66)
- The small delta antigen of hepatitis delta virus is an acetylated protein and acetylation of lysine 72 may influence its cellular localization and viral RNA synthesis. (2004) (65)
- Hepatitis B post‐partum e antigen clearance in hepatitis B carrier mothers: Correlation with viral characteristics (2006) (65)
- Relationship of hepatitis b surface antigen to serum alpha‐fetoprotein in nonmalignant diseases of the liver (1979) (64)
- Continuing Decrease in Hepatitis B Virus Infection 30 Years After Initiation of Infant Vaccination Program in Taiwan. (2016) (64)
- Intraoperative hepatic ultrasonography--an indispensable procedure in resection of small hepatocellular carcinomas. (1985) (64)
- Serum microRNA-122 level correlates with virologic responses to pegylated interferon therapy in chronic hepatitis C (2013) (64)
- Comparative Immunoproteomics of Identification and Characterization of Virulence Factors from Helicobacter pylori Related to Gastric Cancer * S (2006) (64)
- Expression and Hypomethylation of α‐Fetoprotein Gene in Unicentric and Multicentric Human Hepatocellular Carcinomas (1993) (63)
- Long‐term trends and geographic variations in the survival of patients with hepatocellular carcinoma: Analysis of 11 312 patients in Taiwan (2006) (63)
- Prevalence of anti‐HCV and HCV viremia in hemodialysis patients in Taiwan (1992) (62)
- Diverse virological, histopathological and prognostic implications of seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. (1986) (62)
- Do young hepatocellular carcinoma patients have worse prognosis? The paradox of age as a prognostic factor in the survival of hepatocellular carcinoma patients (2006) (61)
- Identification and characterization of intrahepatic hepatitis b virus dna in hbsag‐seronegative patients with chronic liver disease and hepatocellular carcinoma in Taiwan (1990) (61)
- On-Treatment Low Serum HBV RNA Level Predicts Initial Virological Response in Chronic Hepatitis B Patients Receiving Nucleoside Analogue Therapy (2015) (61)
- Genotypes of hepatitis C virus in Taiwan and the progression of liver disease. (1995) (61)
- Comparison of Abbott RealTime HCV Genotype II with Versant Line Probe Assay 2.0 for Hepatitis C Virus Genotyping (2015) (60)
- A Defective Interference-Like Phenomenon of Human Hepatitis B Virus in Chronic Carriers (1998) (60)
- Intratumor injection of absolute ethanol under ultrasound guidance for the treatment of small hepatocellular carcinoma. (1987) (60)
- Expressions of cancer-testis antigens in human hepatocellular carcinomas. (2001) (59)
- Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma. (2006) (59)
- Hepatocellular carcinoma: US evolution in the early stage. (1985) (58)
- Hepatitis C virus RNA in saliva of patients with post-transfusion hepatitis C infection (1991) (58)
- Natural course and treatment of dual hepatitis B virus and hepatitis C virus infections. (2005) (57)
- Transient immunoglobulin M antibody response to hepatitis C virus capsid antigen in posttransfusion hepatitis C: putative serological marker for acute viral infection. (1992) (56)
- Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters. (2012) (56)
- Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen. (1998) (56)
- Phylogenetic analysis of GB virus C: comparison of isolates from Africa, North America, and Taiwan. (1996) (56)
- Low-power laserthermia for the treatment of small hepatocellular carcinoma. (1991) (56)
- Fighting against viral hepatitis: Lessons from Taiwan (2011) (55)
- Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients (1994) (55)
- Overview of Hepatitis B and C Viruses (2000) (55)
- Multiple hepatocellular carcinomas at the early stage have different clonality. (1993) (55)
- Prevalence and implication of a newly identified infectious agent (SEN virus) in Taiwan. (2002) (55)
- Changing seroepidemiology of hepatitis A virus infection in Taiwan (1985) (54)
- Correlation of hepatocyte HBsAg expression with virus replication and liver pathology (1988) (54)
- A seroepidemiologic study of hepatitis B virus infection in Taiwan. (1978) (54)
- Natural course and treatment of hepatitis D virus infection. (2006) (53)
- Systematic Review: Impact of Interferon-based Therapy on HCV-related Hepatocellular Carcinoma (2015) (53)
- High prevalence of mixed genotype infections in hepatitis B virus infected intravenous drug users (2004) (53)
- Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma. (2004) (53)
- Genotypic dominance and novel recombinations in HBV genotype B and C co‐infected intravenous drug users (2004) (53)
- Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. (2009) (53)
- Distinct Relapse Rates and Risk Predictors After Discontinuing Tenofovir and Entecavir Therapy (2018) (52)
- Amplification of GB virus‐C/hepatitis G virus RNA with primers from different regions of the viral genome (1997) (51)
- Hepatitis B virus variants in patients receiving lamivudine treatment with breakthrough hepatitis evaluated by serial viral loads and full‐length viral sequences (2001) (51)
- Temporal profile of hepatitis C virus antibody and genome in infants born to mothers infected with hepatitis C virus but without human immunodeficiency virus coinfection. (1994) (50)
- Maternal transmission of hepatitis B surface antigen in patients with hepatocellular carcinoma in Taiwan. (1980) (50)
- Hepatitis B virus infection, its sequelae, and prevention by vaccination. (2011) (49)
- Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon‐induced hepatitis B e antigen seroconversion (2013) (49)
- Young chronic hepatitis B patients with nucleos(t)ide analogue-induced hepatitis B e antigen seroconversion have a higher risk of HBV reactivation. (2012) (49)
- Dual chronic hepatitis B virus and hepatitis C virus infection (2009) (49)
- Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: Correlation with viral serotypes and clinical stages of liver disease (2002) (49)
- Somatosensory evoked potentials in subclinical portosystemic encephalopathy: A comparison with psychometric tests (1998) (49)
- Hepatitis B virus reactivation in patients receiving cancer chemotherapy: natural history, pathogenesis, and management (2013) (49)
- Application of hepatitis B virus genotyping and phylogenetic analysis in intrafamilial transmission of hepatitis B virus. (2005) (49)
- Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A. (2004) (48)
- Reduced Toll-Like Receptor 3 Expression in Chronic Hepatitis B Patients and Its Restoration by Interferon Therapy (2013) (48)
- Mother-to-infant transmission of GB virus C/hepatitis G virus: the role of high-titered maternal viremia and mode of delivery. (1998) (48)
- Risk stratification of hepatocellular carcinoma in hepatitis B virus e antigen-negative carriers by combining viral biomarkers. (2013) (48)
- Clinical manifestations and survival of hepatocellular carcinoma patients with peritoneal metastasis (2009) (48)
- Posttransfusion hepatitis C virus infection in children. (1994) (48)
- Permanent Inactivation of HBV Genomes by CRISPR/Cas9-Mediated Non-cleavage Base Editing (2020) (47)
- Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis (2004) (47)
- Pathology of chronic hepatitis b virus infection in children: With special reference to the intrahepatic expression of hepatitis B virus antigens (1988) (46)
- Clinical Manifestations and Outcomes of Patients with Sarcomatoid Hepatocellular Carcinoma (2019) (46)
- Sequence analysis of pre‐S/surface and pre‐core/core promoter genes of hepatitis B virus in chronic hepatitis C patients with occult HBV infection (2002) (46)
- Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association. (1995) (46)
- Packaging of hepatitis delta virus RNA via the RNA-binding domain of hepatitis delta antigens: different roles for the small and large delta antigens (1994) (46)
- Clustering of minimal deleted regions reveals distinct genetic pathways of human hepatocellular carcinoma. (2004) (46)
- Decreasing serum alpha-fetoprotein levels in predicting poor prognosis of acute hepatic failure in patients with chronic hepatitis B (2002) (45)
- Large hepatitis delta antigen in packaging and replication inhibition: role of the carboxyl-terminal 19 amino acids and amino-terminal sequences (1995) (45)
- Prevalence and implication of TT virus infection: Minimal role in patients with non‐A–E hepatitis in Taiwan (1999) (45)
- Factors affecting early viral load decline of Asian chronic hepatitis C patients receiving pegylated interferon plus ribavirin therapy (2009) (44)
- Characterization of the Phosphorylated Forms and the Phosphorylated Residues of Hepatitis Delta Virus Delta Antigens (1999) (44)
- Interleukin 28B Genetic Polymorphisms and Viral Factors Help Identify HCV Genotype-1 Patients who Benefit from 24-Week Pegylated Interferon plus Ribavirin Therapy (2012) (44)
- Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B (2010) (44)
- Co‐delivery of GM‐CSF gene enhances the immune responses of hepatitis C viral core protein‐expressing DNA vaccine: Role of dendritic cells (2002) (44)
- Interferon α‐2b with and without ribavirin in the treatment of hepatitis B e antigen–positive chronic hepatitis B: A randomized study (2006) (44)
- Hepatitis B virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinoma. (2004) (43)
- Viral factors correlate with hepatitis B e antigen seroconverson in patients with chronic hepatitis B (2006) (43)
- Cancer prevention in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013. (2013) (43)
- HBsAg profiles in patients receiving peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. (2010) (43)
- Hepatitis B genotypes and precore/basal core promoter mutants in HBeAg-negative chronic hepatitis B (2002) (43)
- Icteric type hepatocellular carcinoma: Revisited 20 years later (1998) (43)
- δ Infection in asymptomatic carriers of hepatitis B surface antigen: Low prevalence of δ activity and effective suppression of hepatitis B virus replication (1988) (43)
- Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection (2017) (43)
- Long term immune response of universal hepatitis B vaccination in infancy: a community-based study in Taiwan. (1999) (43)
- Prevalence of hepatitis C viral infection in a community in Taiwan. Detection by synthetic peptide-based assay and polymerase chain reaction. (1993) (43)
- The Double-stranded RNA-activated Kinase, PKR, Can Phosphorylate Hepatitis D Virus Small Delta Antigen at Functional Serine and Threonine Residues* (2002) (42)
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- The large form of hepatitis 6 antigen is crucial for assembly of hepatitis 6 virus (41)
- Peginterferon alfa-2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 2 receiving haemodialysis: a randomised trial (2014) (41)
- TT virus infection in patients with chronic hepatitis B or C: Influence on clinical, histological and virological features (2000) (40)
- Clearance of hepatitis B surface antigen (HBsAg) after surgical resection of hepatocellular carcinoma. (1987) (40)
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- Plasma des-gamma-carboxyprothrombin in the early stage of hepatocellular carcinoma. (1990) (39)
- A hospital-based study on the use of alternative medicine in patients with chronic liver and gastrointestinal diseases. (2002) (39)
- The Conserved Serine 177 in the Delta Antigen of Hepatitis Delta Virus Is One Putative Phosphorylation Site and Is Required for Efficient Viral RNA Replication (2001) (39)
- Amniocentesis in mothers who are hepatitis B virus carriers does not expose the infant to an increased risk of hepatitis B virus infection (1994) (39)
- Ribavirin up-regulates the activity of double-stranded RNA-activated protein kinase and enhances the action of interferon-alpha against hepatitis C virus. (2007) (39)
- Metabolic profiles in patients with chronic hepatitis C: a case–control study (2008) (39)
- Early predictor of the efficacy of immunoprophylaxis against perinatal hepatitis B transmission: analysis of prophylaxis failure. (1991) (39)
- Pegylated interferon alfa-2a monotherapy for hemodialysis patients with acute hepatitis C. (2010) (38)
- Elevated p53 promotes the processing of miR‐18a to decrease estrogen receptor‐α in female hepatocellular carcinoma (2015) (38)
- Hepatitis C viral infection increases the risk of lymphoid‐neoplasms: A population‐based cohort study (2016) (38)
- Fine mapping of hepatitis B virus pre‐S deletion and its association with hepatocellular carcinoma (2012) (38)
- Public health measures to control hepatitis B virus infection in the developing countries of the Asia–Pacific region (2000) (38)
- HBV genotypes: Epidemiology and implications regarding natural history (2006) (38)
- Intrafamilial transmission of hepatitis C virus in hemodialysis patients (1995) (38)
- Hepatitis D Virus Genotypes in Intravenous Drug Users in Taiwan: Decreasing Prevalence and Lack of Correlation with Hepatitis B Virus Genotypes (2002) (38)
- Hepatitis B Virus in the Colostra of HBeAg‐Positive Carrier Mothers (1993) (38)
- Association of metabolic profiles with hepatic fibrosis in chronic hepatitis C patients with genotype 1 or 2 infection (2010) (38)
- Influence of Metabolic Syndrome, Viral Genotype and Antiviral Therapy on Superimposed Fatty Liver Disease in Chronic Hepatitis C (2005) (38)
- Fibrosis-4 Index Helps Identify HBV Carriers With the Lowest Risk of Hepatocellular Carcinoma (2017) (38)
- Hepatitis C virus in chronic liver disease and hepatocellular carcinoma in Taiwan. (1995) (38)
- Temporal aspects of major viral transcript expression in Hep G2 cells transfected with cloned hepatitis B virus DNA: with emphasis on the X transcript. (1991) (38)
- Hepatitis B vaccination: to boost or not to boost? (2005) (37)
- Metastasis of hepatocellular carcinoma to the heart: unusual patterns in three cases with antemortem diagnosis. (1992) (37)
- Detection of Helicobacter pylori in gastric biopsy tissue by polymerase chain reaction. (1993) (37)
- Serum HBsAg, HBeAg, anti‐HBe, and hepatitis B viral DNA in asymptomatic carriers in Taiwan (1986) (37)
- Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region (2019) (37)
- High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection (2009) (36)
- Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (2006) (36)
- Posttransfusion hepatitis revisited by hepatitis C antibody assays and polymerase chain reaction. (1992) (36)
- Superinfection by homotypic virus in hepatitis C virus carriers: Studies on patients with post‐transfusion hepatitis (1996) (36)
- Evolution of eGFR in chronic HCV patients receiving sofosbuvir-based or sofosbuvir-free direct acting antivirals. (2019) (36)
- Minimal role of hepatitis C virus infection in childhood liver diseases in an area hyperendemic for hepatitis B infection (1993) (36)
- Evolution of Hepatitis B virus in an acute hepatitis B patient co-infected with genotypes B and C. (2006) (36)
- Effective reduction of Helicobacter pylori infection after upper gastrointestinal endoscopy by mechanical washing of the endoscope. (1996) (35)
- Long term clinical and virologic outcome of primary hepatitis C virus infection in children: a prospective study. (1994) (35)
- The ratio of aminotransferase to platelets is a useful index for predicting hepatic fibrosis in hemodialysis patients with chronic hepatitis C. (2010) (35)
- Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11 (2005) (35)
- Esophageal varices: noninvasive diagnosis with duplex Doppler US in patients with compensated cirrhosis. (2008) (35)
- Immunohistochemical studies on intrahepatic lymphocyte infiltrates in chronic type B hepatitis, with special emphasis on the activation status of the lymphocytes. (1988) (34)
- Noninvasive diagnosis of hepatic fibrosis in patients with chronic hepatitis C by splenic Doppler impedance index. (2007) (34)
- Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan. (1993) (34)
- A clinicopathologic study of chronic non-A, non-B (type C) hepatitis in Taiwan: comparison between posttransfusion and sporadic patients. (1994) (34)
- Fraternal hepatocellular carcinoma in young children in two families (1984) (34)
- Clinical significance of serum hepatitis C virus titers in patients with chronic type C hepatitis. (1996) (34)
- High frequency of expression of MAGE genes in human hepatocellular carcinoma. (1999) (34)
- Chronic oral etoposide and tamoxifen in the treatment of far‐advanced hepatocellular carcinoma (1996) (34)
- Hepatitis C virus in a prospective study of posttransfusion non‐A, non‐B hepatitis in Taiwan (1990) (33)
- Identification of the functional regions required for hepatitis D virus replication and transcription by linker-scanning mutagenesis of viral genome. (1997) (33)
- Detection of hepatitis B virus dna in hepatocellular carcinoma: Analysis by hybridization with subgenomic dna fragments (1988) (33)
- Correlation of E-cadherin expression and recurrence of hepatocellular carcinoma. (1999) (33)
- Sexual transmission of HCV (1993) (33)
- GB virus‐C/hepatitis G virus infection in prostitutes: Possible role of sexual transmission (1997) (33)
- Detection of hepatitis B virus DNA in hepatocellular carcinoma. (1986) (32)
- Cytophotometric measurements of nuclear DNA content in hepatocellular carcinomas (1987) (32)
- Metastasis of hepatocellular carcinoma to the proximal jejunum manifested by occult gastrointestinal bleeding. (1987) (32)
- A prospective study of posttransfusion hepatitis in Taiwan. (1991) (32)
- Splicing mutations of the p53 gene in human hepatocellular carcinoma. (1993) (32)
- Depletion of β-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development (2011) (32)
- Long-Term Culture of Hepatocytes from Human Adults (1998) (32)
- Hepatitis B virus genotype B has an earlier emergence of lamivudine resistance than genotype C (2009) (31)
- High prevalence of occult hepatitis B virus infection in Taiwanese intravenous drug users (2007) (31)
- Quasispecies of Hepatitis C Virus and Genetic Drift of the Hypervariable Region in Chronic Type C Hepatitis (1995) (31)
- Report from a Viral Hepatitis Policy Forum on implementing the WHO Framework for Global Action on viral hepatitis in North Asia. (2013) (31)
- Hepatitis B virus infection on Taiwan. (1977) (31)
- Historical epidemiology of hepatitis C virus in select countries—volume 4 (2017) (31)
- Serum cytokine/chemokine profiles in acute exacerbation of chronic hepatitis B: Clinical and mechanistic implications (2014) (31)
- Interspousal transmission of GB virus‐C/hepatitis G virus: A comparison with hepatitis C virus (1997) (31)
- Infrequent mutations and no methylation of CDKN2A (P16/MTS1) and CDKN2B (p15/MTS2) in hepatocellular carcinoma in Taiwan. (1998) (31)
- Ultrasonography in the diagnosis of benign diffuse parenchymal liver diseases: a prospective study. (1988) (30)
- Inverse polymerase chain reaction for cloning cellular sequences adjacent to integrated hepatitis B virus DNA in hepatocellular carcinomas. (1994) (30)
- N-linked glycosylation of hepatitis B surface antigens is involved but not essential in the assembly of hepatitis delta virus. (1996) (30)
- Isolation of a complementary DNA fragment of hepatitis C virus in Taiwan revealed significant sequence variations compared with other isolates (1991) (30)
- Serum α-Fetoprotein Levels in Normal Infants: A Reappraisal of Regression Analysis and Sex Difference (1989) (30)
- Hepatocyte growth factor stimulates the growth and activates mitogen-activated protein kinase in human hepatoma cells. (1998) (30)
- Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B. (2009) (30)
- Positive and negative strand of hepatitis C virus RNA sequences in peripheral blood mononuclear cells in patients with chronic hepatitis C: No correlation with viral genotypes 1b, 2a, and 2b (1997) (30)
- New Insights into the Evolutionary Rate of Hepatitis B Virus at Different Biological Scales (2015) (30)
- Mechanism of vertical transmission of hepatitis G (1996) (29)
- Amebic liver abscess and human immunodeficiency virus infection: a report of three cases. (2001) (29)
- Adipocytokines and liver fibrosis stages in patients with chronic hepatitis B virus infection (2015) (29)
- Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice (2016) (29)
- Concurrent delivery of GM‐CSF and endostatin genes by a single adenoviral vector provides a synergistic effect on the treatment of orthotopic liver tumors (2003) (29)
- Low prevalence of hepatitis C virus infection among dentists in Taiwan (1993) (29)
- Analysis of rearranged T cell receptor (TCR) Vβ transcripts in livers of primary biliary cirrhosis: preferential Vβ usage suggests antigen‐driven selection (1996) (29)
- SEN virus infection in patients with chronic hepatitis C: preferential coinfection with hepatitis C genotype 2a and no effect on response to therapy with interferon plus ribavirin. (2003) (28)
- Efficacy of a mass hepatitis B immunization program after switching to recombinant hepatitis B vaccine: a population-based study in Taiwan. (2001) (28)
- Chronic hepatitis B is associated with an increased risk of B‐cell non‐Hodgkin's lymphoma and multiple myeloma (2019) (28)
- Continuous expression and replication of the hepatitis delta virus genome in Hep G2 hepatoblastoma cells transfected with cloned viral DNA. (1990) (28)
- Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection. (1994) (28)
- Improved Serodiagnosis of Posttransfusion Hepatitis C Virus Infection by a Second‐Generation Immunoassay Based on Multiple Recombinant Antigens (1992) (28)
- Biologic significance of the detection of HBsAg and HBcAg in liver and tumor from 204 HBsAg‐positive patients with primary hepatocellular carcinoma (1989) (28)
- DNA clonal heterogeneity of hepatocellular carcinoma demonstrated by Feulgen-DNA analysis. (2008) (27)
- Sofosbuvir-based Interferon-Free Direct Acting Antiviral Regimens for Heart Transplant Recipients With Chronic Hepatitis C Virus Infection (2018) (27)
- Real‐world effectiveness and safety of paritaprevir/ritonavir, ombitasvir, and dasabuvir with or without ribavirin for patients with chronic hepatitis C virus genotype 1b infection in Taiwan (2018) (27)
- HEV superinfection accelerates disease progression in patients with chronic HBV infection and increases mortality in those with cirrhosis. (2020) (27)
- Status of hepatitis B virus DNA in hepatocellular carcinoma: A study based on paired tumor and nontumor liver tissues (1988) (27)
- Non‐A, non‐B hepatitis in children: A clinical, histologic, and serologic study (1991) (27)
- Bacterial infections associated with hepatic arteriography and transarterial embolization for hepatocellular carcinoma: a prospective study. (1999) (27)
- Viral hepatitis in East Asia. (1996) (27)
- Quasispecies of hepatitis C virus and genetic drift of the hypervariable region in chronic type C hepatitis. (1995) (26)
- Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis‐C virus infection in Taiwan: a prospective study (2003) (25)
- Prevalence and clinical implications of HFE gene mutations (C282Y and H63D) in patients with chronic hepatitis B and C in Taiwan (2005) (25)
- The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4 (2017) (25)
- Low prevalence of hepatitis C virus and infrequent perinatal or spouse infections in pregnant women in Taiwan (1991) (25)
- Albumin messenger RNA is not specific for circulating hepatoma cells. (1994) (25)
- Generic sofosbuvir-based interferon-free direct acting antiviral agents for patients with chronic hepatitis C virus infection: a real-world multicenter observational study (2018) (25)
- Detection of hepatitis B virus DNA in hepatocellular carcinoma: methylation of integrated viral DNA. (1988) (25)
- Clinicopathologic studies of asymptomatic HBsAg carriers: with special emphasis on carriers older than 40 years. (1987) (25)
- Interleukin 28B Genetic Polymorphisms Play a Minor Role in Identifying Optimal Treatment Duration in HCV Genotype 1 Slow Responders to Pegylated Interferon plus Ribavirin (2012) (25)
- Original ArticlesGenetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study☆ (2002) (25)
- Hepatitis C Viral Infection in Thalassemic Children: Clinical and Molecular Studies (1996) (24)
- Hepatitis B e antigen and its antibody in chronic type B hepatitis (1987) (24)
- Telomerase activity and telomere length in human hepatocellular carcinoma. (1998) (24)
- Clustering of different subtypes of hepatitis B surface antigen in families of patients with chronic liver diseases. (1978) (24)
- Prevention of hepatitis B. (2015) (24)
- Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection (2002) (24)
- Plasma Adipokines and Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Virus–Infected Carriers: A Prospective Study in Taiwan (2014) (24)
- Lymphocyte Antigen 6 Complex, Locus C+ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice (2019) (24)
- Complete agenesis of the dorsal pancreas--a case report and review of the literature. (1990) (24)
- Dominance of functional androgen receptor allele with longer CAG repeat in hepatitis B virus-related female hepatocarcinogenesis. (2002) (24)
- Early acquisition of TT virus in infants: Possible minor role of maternal transmission (2002) (24)
- HLA-A, B, C and DR antigens in chronic hepatitis B viral infection. (1989) (23)
- Clinical relevance of hepatitis B virus genotypes Ba and Bj in Taiwan. (2003) (23)
- Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasis (2010) (23)
- Clinical impact of screening first-degree relatives of patients with hepatocellular carcinoma. (1998) (23)
- Detection of hepatitis B viral DNA by polymerase chain reaction in patients with hepatitis B surface antigen (1990) (23)
- ADAR2-Mediated Editing of miR-214 and miR-122 Precursor and Antisense RNA Transcripts in Liver Cancers (2013) (23)
- Evolution of precore/core promoter mutations in hepatitis B carriers with hepatitis B e antigen seroreversion (2004) (23)
- Cell‐Free Virus‐Host Chimera DNA From Hepatitis B Virus Integration Sites as a Circulating Biomarker of Hepatocellular Cancer (2020) (23)
- Cytogenetic studies on human liver cancer cell lines. (1993) (22)
- Reduced Toll-Like Receptor 9 Expression on Peripheral C D14+ Monocytes of Chronic Hepatitis B Patients and its Restoration by Effective Therapy (2014) (22)
- Delta‐agent infection in Taiwan (1987) (22)
- Ribavirin Enhances Interferon-γ Levels in Patients with Chronic Hepatitis C Treated with Interferon-α (2001) (22)
- Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma (2007) (22)
- Reactivation of Hepatitis B Virus in Rheumatologic Patients Receiving Immunosuppressive Agents (2006) (22)
- Characteristics of hepatocellular carcinoma presenting with variceal bleeding (1998) (22)
- Serum interleukin 6 level correlates with outcomes of acute exacerbation of chronic hepatitis B (2012) (22)
- Taiwan commits to eliminating hepatitis C in 2025. (2019) (21)
- Milder clinical manifestation of scrub typhus in Kinmen, Taiwan. (2013) (21)
- Mutations in the NS5A and E2‐PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin (2003) (21)
- Correlation of HBV DNA levels in serum and liver of chronic hepatitis B patients with cirrhosis. (2002) (21)
- Strategies to manage hepatitis C virus infection disease burden—Volume 4 (2017) (21)
- [Hepatocellular carcinoma: 30 years' experience in Taiwan]. (1992) (21)
- Longitudinal Change of HBsAg in HBeAg-negative Patients with Genotype B or C Infection (2013) (21)
- Epigenetic activation of α4, β2 and β6 integrins involved in cell migration in trichostatin A-treated Hep3B cells (2005) (21)
- Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication. (1988) (21)
- Long-Term Protection of Hepatitis B Vaccine: Lessons from Alaskan Experience after 15 Years (2005) (21)
- Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients (2016) (21)
- Hepatitis C virus infection in volunteer blood donors in Taiwan. Evaluation by hepatitis C antibody assays and the polymerase chain reaction. (1993) (20)
- Consolidation therapy for HBeAg-positive Asian chronic hepatitis B patients receiving lamivudine treatment: a multicentre study. (2013) (20)
- Early Viral Kinetics during Treatment of Chronic Hepatitis C Virus Infection with Pegylated Interferon Alpha plus Ribavirin in Taiwan (2007) (20)
- Hepatitis C virus infection in Taiwan (1991) (20)
- Allelic loss of chromosome 4q21 ≈︁ 23 associates with hepatitis B Virus—related hepatocarcinogenesis and elevated alpha‐fetoprotein (2004) (20)
- Recent research progress in hepatocellular carcinoma. (2002) (20)
- Portal blood flow in acute hepatitis with and without ascites: A non‐invasive measurement using an ultrasonic Doppler (1995) (20)
- Allelic loss of chromosome 4q21 approximately 23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein. (2004) (20)
- Hepatitis delta virus cDNA monomer can be used in transfection experiments to initiate viral RNA replication. (1993) (20)
- Hepatitis D virus infection in children with acute or chronic hepatitis B virus infection in Taiwan. (1988) (20)
- Absence or delayed appearance of hepatitis B core antibody in chronic hepatitis B surface antigen carrier children. (1993) (20)
- Origin of serum hepatitis B virus in acute exacerbation: Comparison with HBV in the liver and from other exacerbation (2004) (19)
- Hepatitis B Surface Antigen Loss and Hepatocellular Carcinoma Development in Patients With Dual Hepatitis B and C Infection (2016) (19)
- Effect of hepatitis C antibody screening in blood donors on post‐transfusion hepatitis in Taiwan (1995) (19)
- Dynamics of plasma hepatitis B virus levels after highly active antiretroviral therapy in patients with HIV infection. (2003) (19)
- Studies on the subtypes of hepatitis B surface antigen-demonstration of vertical and intrafamilial transmission of hepatitis B virus. (1978) (19)
- Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver through SHP-1. (2015) (19)
- Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection and severe renal impairment (2020) (19)
- Long-term follow-up of hepatic hemangiomas by ultrasonography: with emphasis on the growth rate of the tumor. (2007) (19)
- Clinical features, etiology, and survival of hepatocellular carcinoma among different countries (2002) (19)
- Quantitative detection of hepatitis B virus DNA in human sera by branched-DNA signal amplification. (1995) (19)
- Real-world effectiveness and safety of glecaprevir/pibrentasvir in Asian patients with chronic hepatitis C. (2019) (19)
- Long-Term Follow-Up of Hepatitis B Surface Antibody Levels in Subjects Receiving Universal Hepatitis B Vaccination in Infancy in an Area of Hyperendemicity: Correlation between Radioimmunoassay and Enzyme Immunoassay (2005) (19)
- Long-Term Effect of Interferon Plus Ribavirin on Hepatitis B Surface Antigen Seroclearance in Patients Dually Infected with Hepatitis B and C Viruses (2011) (19)
- Long-term culture of hepatocytes from human adults. (1998) (19)
- Genome‐wide association analysis identifies a GLUL haplotype for familial hepatitis B virus‐related hepatocellular carcinoma (2017) (18)
- Hepatitis E virus and posttransfusion hepatitis. (1994) (18)
- Prospects for hepatitis B virus eradication and control of hepatocellular carcinoma. (1999) (18)
- A higher alanine aminotransferase level correlates with earlier hepatitis B e antigen seroconversion in lamivudine‐treated chronic hepatitis B patients (2008) (18)
- Comparison of two methods for quantification of hepatitis B viral DNA (1999) (18)
- Alcoholism, hepatitis B and C viral infections, and impaired liver function among Taiwanese aboriginal groups. (1996) (18)
- Hepatitis B and hepatitis C virus infection among chronic alcoholic patients with liver disease in Taiwan. (1994) (18)
- Noninvasive Diagnosis of Advanced Pancreatic Cancer by Real‐Time Ultrasonography, Carcinoembryonic Antigen, and Carbohydrate Antigen 19‐9 (1986) (17)
- Peginterferon α in the treatment of chronic hepatitis B (2014) (17)
- Clinical significance and evolution of hepatic HBsAg expression in HBeAg-positive patients receiving interferon therapy (2014) (17)
- Less reversal of liver fibrosis after prolonged carbon tetrachloride injection. (2001) (17)
- GB virus C infection in hemodialysis patients: molecular evidence for nosocomial transmission. (1999) (17)
- Antibodies to E2 protein of hepatitis G virus in children: different responses according to age at infection. (1998) (17)
- A noninvasive diagnosis of hepatic fibrosis by BioFibroScore® in chronic hepatitis C patients (2018) (17)
- A placebo-controlled, double-blind study of sucralfate in the short-term treatment of duodenal ulcer. (1983) (17)
- Hepatitis B surface antigen level complements viral load in predicting viral reactivation in spontaneous HBeAg seroconverters (2014) (17)
- Sofosbuvir‐based direct acting antiviral therapies for patients with hepatitis C virus genotype 2 infection (2019) (17)
- Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection: Real‐world effectiveness and safety in Taiwan (2019) (17)
- Higher cut‐off index value of immunoglobulin M antibody to hepatitis B core antigen in Taiwanese patients with hepatitis B (2006) (17)
- Chronic hepatitis C without anti-hepatitis C antibodies by second-generation assay (2005) (17)
- Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. (2005) (17)
- Hepatitis B Virus Nucleocapsid but Not Free Core Antigen Controls Viral Clearance in Mice (2012) (17)
- Subgenotypes of hepatitis B virus genotype C do not correlate with disease progression of chronic hepatitis B in Taiwan (2007) (16)
- Serotyping of hepatitis C virus in chronic type C hepatitis in Taiwan: Correlation with genotypes (1996) (16)
- Positive and negative strand of hepatitis C virus RNA sequences in peripheral blood mononuclear cells in patients with chronic hepatitis C: no correlation with viral genotypes 1b, 2a, and 2b. (1997) (16)
- A forgotten population with chronic hepatitis C infection: Subjects coinfected with hepatitis B virus (2004) (16)
- Recent updates in hepatitis vaccination and the prevention of hepatocellular carcinoma (2002) (16)
- Role of zinc in subclinical hepatic encephalopathy: Comparison with somatosensory‐evoked potentials (2004) (16)
- Molecular epidemiology of hepatitis B viral serotypes and genotypes in taiwan. (2002) (16)
- Hepatitis A virus infection in Taipei City in 1989. (1991) (16)
- Evolution of hepatitis B virus precore/basal core promoter gene in HBeAg‐positive chronic hepatitis B patients receiving lamivudine therapy (2004) (16)
- Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein. (1996) (16)
- Serum p53 gene polymorphisms and severity of hepatitis B or C-related chronic liver diseases in Taiwan (2011) (16)
- Inadequacy of lmmunoglobulin M hepatitis B core antibody in detecting acute hepatitis B virus infection in infants of HBsAg carrier mothers (1985) (15)
- Impact of occult hepatitis B on the clinical outcomes of patients with chronic hepatitis C virus infection: A 10-year follow-up. (2017) (15)
- Baseline Mac-2 Binding Protein Glycosylation Isomer Level Stratifies Risks of Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Oral Antiviral Therapy (2020) (15)
- Ribavirin Enhances the Action of Interferon-α against Hepatitis C Virus by Promoting the p53 Activity through the ERK1/2 Pathway (2012) (15)
- De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline (2017) (15)
- Curative potential of GM-CSF-secreting tumor cell vaccines on established orthotopic liver tumors: mechanisms for the superior antitumor activity of live tumor cell vaccines. (2004) (15)
- Serum hepatitis B surface antigen levels help predict disease progression in patients with low HBV loads. (2012) (15)
- Decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers (2019) (14)
- Natural history of hepatitis B surface antigen‐positive cirrhosis in Taiwan: A clinicopathological study (1988) (14)
- Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels (2009) (14)
- Kinetics of hepatitis B virus reactivation after chemotherapy: more questions than answers. (2006) (14)
- Hepatitis D virus infection among intravenous drug abusers in Taiwan: Analysis of risk factors and liver function tests (1990) (14)
- Perspectives on dual hepatitis B and C infection in Taiwan. (2016) (14)
- Association of SCARB1 Gene Polymorphisms with Virological Response in Chronic Hepatitis C Patients Receiving Pegylated Interferon plus Ribavirin Therapy (2016) (14)
- Molecular biology of hepatitis D virus: Research and potential for application (1997) (14)
- Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection (2014) (14)
- Selective transmission of hepatitis C virus quasi species through a needlestick accident in acute resolving hepatitis. (2006) (14)
- GB Virus-C/Hepatitis G Virus Infection in Taiwan: A Virus That Fails to Cause a Disease? (1999) (14)
- HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice (2020) (13)
- Post‐partum acute exacerbation of chronic hepatitis in a hepatitis C‐carrier mother (2001) (13)
- Minimal role of GB virus‐C/hepatitis G virus in fulminant and subfulminant hepatitis in Taiwan (1999) (13)
- Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection (2010) (13)
- Clinical and virological features of occult hepatitis B in patients with HBsAg seroclearance post‐treatment or spontaneously (2014) (13)
- Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury (2007) (13)
- Molecular methods of measurement of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infection: implications for occupational health practice. (1999) (13)
- Hepatitis A vaccine in healthy adults: a comparison of immunogenicity and reactogenicity between two- and three-dose regimens. (1999) (13)
- Mixed hepatitis B virus genotype infections: The more, the worse? (2006) (12)
- Evolution of expression of hepatitis B surface and core antigens (HBsAg, HBcAg) in resected primary and recurrent hepatocellular carcinoma in HBsAg carriers in Taiwan. Correlation with local host immune response (1988) (12)
- No more excuses: viral hepatitis can be eliminated (2016) (12)
- Acoustic Radiation Force Impulse US Imaging: Liver Stiffness in Patients with Chronic Hepatitis B with and without Antiviral Therapy. (2018) (12)
- Real-world effectiveness and safety of sofosbuvir and ledipasvir with or without ribavirin for patients with hepatitis C virus genotype 1 infection in Taiwan (2018) (12)
- GBV-C/HGV infection and aplastic anaemia (1996) (12)
- Lack of Interferon Sensitivity-Determining Region in the Genome of Hepatitis B Virus Genotype Ba (2004) (12)
- Blood-bank screening for hepatitis G (1997) (12)
- Feedback regulation of IFN‐α/β signaling by Axl receptor tyrosine kinase modulates HBV immunity (2015) (12)
- End-of-treatment virologic response does not predict relapse after lamivudine treatment for chronic hepatitis B. (2004) (12)
- Efficacy of consensus interferon in the treatment of chronic hepatitis C (2000) (12)
- Pancreatic carcinoma associated with chronic calcifying pancreatitis in Taiwan: a case report and review of the literature. (1988) (12)
- Viral hepatitis: from A to E, and beyond? (2003) (12)
- Ribavirin enhances interferon-gamma levels in patients with chronic hepatitis C treated with interferon-alpha. (2001) (12)
- Peginterferon plus Ribavirin for HIV-infected Patients with Treatment-Naïve Acute or Chronic HCV Infection in Taiwan: A Prospective Cohort Study (2015) (12)
- HBeAg and anti-HBe in chronic hepatitis B virus infection. (1981) (12)
- HBV genotypes and outcome of HBV infection (2005) (11)
- Universal hepatitis B vaccination: killing 2 birds with 1 stone. (2008) (11)
- Taiwan is on track of accelerating hepatitis C elimination by 2025 (2020) (11)
- Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis (2017) (11)
- Hepatitis Be antigen and antibody in chronic liver diseases and hepatocellular carcinoma. (1981) (11)
- Comparison of Three Different Immunoassays and PCR for the Detection of Hepatitis C Virus Infection in Pregnant Women in Taiwan (1993) (11)
- Safety and immunogenicity of hepatitis A vaccine in healthy adult volunteers (1993) (11)
- Serum hepatitis C virus titers in the progression of type C chronic liver disease. With special emphasis on patients with type 1b infection. (1996) (11)
- Perinatal transmission of hepatitis B virus in the Taoyuan area. (1986) (11)
- Hepatitis B virus Quantification and Detection of YMDD Mutants in a Single Reaction by Real-Time PCR and Annealing Curve Analysis (2008) (11)
- Lack of Critical Domains in the β-Chain of Hepatocyte Growth Factor (1995) (10)
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- Mapping the conformational epitope of a therapeutic monoclonal antibody against HBsAg by in vivo selection of HBV escape variants (2021) (0)
- Statins Reduce Esophageal Variceal Bleeding in Chronic Hepatitis B Patients with Cirrhosis: A Nationwide Cohort Study (2016) (0)
- Isolation of A cDNA Fragment of Hepatitis C Virus in Taiwan Revealed a Hypervariable Region of NS1/E2 Gene: Its Implications for the Significance of Viral Genomic Heterogeneity (1991) (0)
- Metastatic tumor antigen 1 contributes to hepatocarcinogenesis posttranscriptionally through RNA‐binding function (2022) (0)
- Hepatocyte Growth Factor Stimulates the Growth and Activates Mitogen-Activated Protein Kinase in Human Hepatoma Cells (1998) (0)
- Generic sofosbuvir-based interferon-free direct acting antiviral agents for patients with chronic hepatitis C virus infection: a real-world multicenter observational study (2018) (0)
- Levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in sera and pancreatic juice in the diagnosis of pancreatic cancer. (1987) (0)
- Studies on duck hepatitis B virus: Identification and epidemiological survey in Taiwan (1987) (0)
- De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline (2017) (0)
- Gene Expression and Interaction of HDV with HBV in an Hep G2 Cell Line Containing Integrated Cloned HDV DNA (1990) (0)
- O.076 Development of RNA interference-based strategies to control hepatitis B virus clinical isolate of various genotypes and mutants and prevent emergence of resistant mutants (2006) (0)
- Interferon-Based Therapy for the Treatment of Chronic Hepatitis B and C in Taiwan (2005) (0)
- Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis (2017) (0)
- Lower Alanine Aminotransferase Level and Higher Hepatitis B Viral Load at Baseline Correlate with Earlier Emergence of Lamivudine Resistance in Taiwanese Patients: 314 (2009) (0)
- A Survey on the Prevalence of Hepatocellular Carcinoma and Hepatitis B Virus Infection in Peng-Hu, Taiwan (1988) (0)
- HBsAg, HBsAb, immunoglobulins and C3 in primary nephrotic syndrome. (1978) (0)
- Organization of The Third International Symposium on Viral Hepatitis and Hepatocellular Carcinoma (1993) (0)
- Flow Index of 3D Breast Ultrasound was Strongly Correlated with Axillary Lymph Nodes Metastases in the Absence of Lymphovascular Invasion (2011) (0)
- Comparisons of Ultrasonography and Liver Function Tests in the Detection of Liver Cirrhosis Due to Viral Hepatitis B or C (1995) (0)
- Thelarge formofhepatitis 6antigen iscrucial forassembly of hepatitis 6virus (1991) (0)
- Changes of Gastric Mucosal Blood Flow in Gastric Ulcer Patients (1988) (0)
- Viral hepatitis and hepatocellular carcinoma : proceedings of the Second International Symposium on Viral Hepatitis and Hepatocellular Carcinoma, Taipei, December 7-9, 1988 (1990) (0)
- Sorafenib and SC-1 Exhibit Anti-fibrotic Effects Through Signal Transducer and Activator of Transcription 3 Inhibition (2015) (0)
- Sensorineural Hearing Loss and Brain Stem Auditory Evoked Potential Changes During Interferon Therapy: A Prospective Study in Nine Patients (1998) (0)
- P639 SPONTANEOUS SEROCLEARANCE OF HBsAg IN HEPATITIS B VIRUS/HEPATITIS C VIRUS DUALLY INFECTED PATIENTS: A 10-YEAR FOLLOW-UP (2014) (0)
- A study on orcein staining of hepatitis B surface antigen in primary glomerulonephritis. (1979) (0)
- 616 HEPATITIS B GENOMIC VARIABILITY CORRELATES WITH INTRAHEPATIC VIRAL ANTIGEN EXPRESSION (2010) (0)
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