Dion Morton
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British surgeon
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Gastroenterology
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Medical Philosophy
Dion Morton's Degrees
- Masters Medicine University of Oxford
Why Is Dion Morton Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dion Gregory Morton is a leading colorectal surgeon at the University of Birmingham, where he has been Professor of Surgery since 2006. He was appointed Barling Chair of Surgery at the University of Birmingham in 2015. In addition he has served as Director of Clinical Research at the Royal College of Surgeons of England since 2011. In the latter role he has worked to establish a national infrastructure to support the development and dissemination of clinical trials in surgery. He has championed the role of large-scale multi centre randomised controlled trials in informing best practice in surgery.
Dion Morton's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. (2005) (2544)
- Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study (2020) (980)
- A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. (2006) (441)
- The Wnt Antagonist sFRP1 in Colorectal Tumorigenesis (2004) (275)
- Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial (2012) (224)
- Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial (2008) (220)
- Impact of wound edge protection devices on surgical site infection after laparotomy: multicentre randomised controlled trial (ROSSINI Trial) (2013) (214)
- Global burden of postoperative death (2019) (194)
- Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition (1999) (190)
- Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis. (1994) (158)
- Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers (2004) (146)
- SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. (2003) (138)
- Incidental lesions found on CT colonography: their nature and frequency. (2005) (136)
- FOxTROT: an international randomised controlled trial in 1052 patients (pts) evaluating neoadjuvant chemotherapy (NAC) for colon cancer. (2019) (132)
- Stapled versus sutured closure of loop ileostomy: a randomized controlled trial. (2000) (119)
- Loss of heterozygosity of the retinoblastoma and adenomatous polyposis susceptibility gene loci and in chromosomes 10p, 10q and 16q in human prostate cancer. (1994) (108)
- CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations (2005) (108)
- Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) (2017) (105)
- Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer (2002) (97)
- Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo‐caecal resection: an international snapshot audit (2017) (87)
- Desmocollin switching in colorectal cancer (2006) (81)
- Core Outcomes for Colorectal Cancer Surgery: A Consensus Study (2016) (77)
- Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon (2002) (74)
- Randomized Trial of Oral Sodium Phosphate Compared with Oral Sodium Picosulphate (Picolax) for Elective Colorectal Surgery and Colonoscopy (2000) (73)
- Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial. (2007) (73)
- Analysis of the Birt–Hogg–Dubé (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer (2003) (68)
- Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study (2020) (64)
- Genotype-phenotype correlation between position of constitutional APC gene mutation and CHRPE expression in familial adenomatous polyposis (1994) (64)
- A systematic review of outcome reporting in colorectal cancer surgery (2013) (63)
- Results of restorative proctocolectomy in the elderly (1997) (63)
- Resources and costs associated with incidental extracolonic findings from CT colonogaphy: a study in a symptomatic population. (2006) (62)
- Patient experiences of colonoscopy, barium enema and CT colonography: a qualitative study. (2009) (57)
- Allelic loss on chromosomes 8p, 22q and 18q (DCC) in human prostate cancer (1996) (55)
- The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019) (2015) (53)
- Systematic review of evidence and consensus on perianal fistula: an analysis of national and international guidelines (2016) (51)
- Interventions in randomised controlled trials in surgery: issues to consider during trial design (2015) (50)
- Methylation profiling of rectal cancer identifies novel markers of early‐stage disease (2011) (50)
- Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi‐centre, prospective audit (2018) (50)
- Role of congenital hypertrophy of the retinal pigment epithelium in the predictive diagnosis of familial adenomatous polyposis (1992) (47)
- An unusually severe phenotype for familial adenomatous polyposis (1997) (45)
- Predictive diagnosis of familial adenomatous polyposis with linked DNA markers: population based study. (1992) (44)
- Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. (2013) (44)
- An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME) (2018) (43)
- Surgical site infection and costs in low- and middle-income countries: A systematic review of the economic burden (2020) (42)
- Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery (2015) (42)
- The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas (2006) (42)
- CT colonography: interpretative performance in a non-academic environment. (2007) (40)
- Adenocarcinoma of the Small Bowel Arising From a Previous Strictureplasty for Crohn’s Disease: Report of a Case (2007) (40)
- A Systematic Review of Systematic Reviews and Panoramic Meta-Analysis: Staples versus Sutures for Surgical Procedures (2013) (37)
- Chronic pancreatitis and pancreatic carcinoma. (1997) (36)
- Two novel regions of interstitial deletion on chromosome 8p in colorectal cancer (1999) (36)
- Recognising contributions to work in research collaboratives: Guidelines for standardising reporting of authorship in collaborative research. (2017) (33)
- Prioritizing research for patients requiring surgery in low‐ and middle‐income countries (2019) (31)
- CREST: Randomised phase III study of stenting as a bridge to surgery in obstructing colorectal cancer--Results of the UK ColoRectal Endoscopic Stenting Trial (CREST). (2016) (31)
- Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER (2017) (28)
- Reinforcement of closure of stoma site using a biological mesh (2014) (28)
- Reorganisation of Wnt-response pathways in colorectal tumorigenesis (2008) (27)
- Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial (2020) (27)
- Mechanisms of immunogenicity in colorectal cancer (2019) (26)
- Protocol for a multicentre, prospective, population-based cohort study of variation in practice of cholecystectomy and surgical outcomes (The CholeS study) (2015) (26)
- Quality of life after pouch excision (1998) (26)
- The impact of stapling technique and surgeon specialism on anastomotic failure after right‐sided colorectal resection: an international multicentre, prospective audit (2018) (26)
- Safety of primary anastomosis following emergency left sided colorectal resection: an international, multi‐centre prospective audit (2018) (26)
- The Cost-Effectiveness of Wound-Edge Protection Devices Compared to Standard Care in Reducing Surgical Site Infection after Laparotomy: An Economic Evaluation alongside the ROSSINI Trial (2014) (25)
- GRIST: Growing Recruitment in Interventional and Surgical Trials (2012) (25)
- Effect of hysterectomy status on polyp detection rates at screening flexible sigmoidoscopy. (2003) (24)
- Systematic review of the stage of innovation of biological mesh for complex or contaminated abdominal wall closure (2018) (24)
- Audit of topical glyceryl trinitrate for treatment of fissure-in-ano. (2000) (24)
- Consensus and controversies regarding follow‐up after treatment with curative intent of nonmetastatic colorectal cancer: a synopsis of guidelines used in countries represented in the European Society of Coloproctology (2019) (20)
- Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study. (2020) (20)
- Reduction of surgical site infection using a novel intervention (ROSSINI): study protocol for a randomised controlled trial (2011) (20)
- Surgical resection of lung cancer England: more operations but no trials to test their effectiveness (2012) (20)
- Preliminary results of a feasibility study of the use of information technology for identification of suspected colorectal cancer in primary care: the CREDIBLE study (2015) (18)
- SLIT 2 Axon Guidance Molecule Is Frequently Inactivated in Colorectal Cancer and Suppresses Growth of Colorectal Carcinoma Cells 1 (2003) (18)
- Transient P‐cadherin expression in radiation proctitis; a model of mucosal injury and repair (2002) (18)
- Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery (2018) (17)
- COVID-19-related absence among surgeons: development of an international surgical workforce prediction model (2020) (17)
- Wnt signalling in adenomas of familial adenomatous polyposis patients (2010) (16)
- Dexamethasone reduces emesis after major gastrointestinal surgery (DREAMS) (2013) (16)
- Loss of Expression and Promoter Methylation of SLIT2 Are Associated with Sessile Serrated Adenoma Formation (2013) (16)
- Biomarker-based treatment selection in early-stage rectal cancer to promote organ preservation (2014) (15)
- Mismatch repair status and synchronous metastases in colorectal cancer: A nationwide cohort study (2015) (15)
- The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit (2018) (14)
- Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3) (2019) (14)
- The digestive system : basic science and clinical (2010) (14)
- The outcome of surgery in fulminant Clostridium difficile colitis (2006) (12)
- Erratum to: The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019) (2016) (11)
- ESCP Safe Anastomosis ProGramme in CoLorectal SurgEry (EAGLE): Study protocol for an international cluster randomised trial of a quality improvement intervention to reduce anastomotic leak following right colectomy (2021) (11)
- Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia (2022) (11)
- Influence of day of surgery on mortality following elective colorectal resections (2015) (10)
- Identifying a Basket of Surgical Procedures to Standardize Global Surgical Metrics (2020) (10)
- Defunctioning stomas in the treatment of rectal cancer (2006) (10)
- Development of a core information set for colorectal cancer surgery: a consensus study (2019) (9)
- Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia (2018) (8)
- Impact of tissue processing, archiving and enrichment techniques on DNA methylation yield in rectal carcinoma. (2013) (8)
- Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study (2018) (8)
- Is this laparoscopic technique study the perfect surgical trial? (2016) (8)
- Use of an online e-learning module to standardise the assessment and reporting of a subjective endpoint in a multicentre rct (2013) (7)
- In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer (2020) (7)
- RCS to Expand Surgical Research Infrastructure (2012) (7)
- Upper Gastrointestinal Events Associated With Rofecoxib in a Colorectal Adenoma Chemoprevention Trial (2005) (6)
- The use of DNA from paraffin wax preserved tissue for predictive diagnosis in familial adenomatous polyposis. (1992) (6)
- Should surgical training include involvement in a clinical trial? (2015) (5)
- Selecting patients with young‐onset colorectal cancer for mismatch repair gene analysis (2007) (5)
- Evaluation of serum lysyl oxidase as a blood test for colorectal cancer. (2014) (5)
- [Prospective national study of complicated diverticulitis in Great Britain]. (1995) (5)
- The need for multidisciplinarity in specialist training to optimize future patient care (2017) (5)
- Evaluation of an early‐stage innovation for full‐thickness excision of benign colonic polyps using the IDEAL framework (2019) (4)
- The impact of preoperative oral nutrition supplementation on outcomes in patients undergoing gastrointestinal surgery for cancer in low- and middle-income countries: a systematic review and meta-analysis (2022) (4)
- The molecular landscape of well differentiated retroperitoneal liposarcoma (2021) (3)
- A national platform for molecular diagnostics: Results of the Cancer Research UK Stratified Medicine Programme (2014) (3)
- Abnormal P-cadherin and altered expression of B-catenin in ulcerative colitis associated dysplasia and colorectal cancer (2001) (3)
- Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme (2018) (3)
- Rational centre selection for RCTs with a parallel economic evaluation--the next step towards increased generalisability? (2015) (3)
- The development of a colorectal cancer surgery core outcome set (2015) (3)
- Trial outcomes and information for clinical decision-making: a comparative study of opinions of health professionals (2016) (2)
- Surgical resection of lung cancer in England: more operations but no trials to test their effectiveness (2012) (2)
- Biologics against cancer-specific receptors - challenges to personalised medicine from early trial results. (2012) (2)
- Letter to the Editor: Methodological advances in randomized trials. (2016) (2)
- FOxTROT: Randomized phase II study of neoadjuvant chemotherapy (CT) with or without an anti-EGFR monoclonal antibody for locally advanced, operable colon cancer: Planned interim report. (2011) (2)
- Cinical Outcome of Surgery for Fulminant Clostridium Difficile Colitis (2004) (2)
- Novel approaches to surgical trials and the assessment of new surgical technologies (2015) (2)
- The ACCURE-UK trial: The effect of appendectomy on the clinical course of ulcerative colitis – A feasibility study (2016) (1)
- Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery (2023) (1)
- Preliminary model assessing the cost-effectiveness of preoperative chlorhexidine mouthwash at reducing postoperative pneumonia among abdominal surgery patients in South Africa (2021) (1)
- Hereditary colorectal cancer: screen the parents (!) (2008) (1)
- Pre-operative FOLFOX chemotherapy in advanced colon cancer: Pathology analysis of the FOxTROT trial (2019) (1)
- Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia (2022) (1)
- Trials Symposium (2012) (1)
- KRAS and BRAF Mutational Status can be Accurately Determined on Diagnostic Tissue Biopsies: An Analysis of Matched Biopsy and Resection Material from Patients with Colon Cancer in the NCRI FOxTROT trial (2012) (1)
- FOxTROT:Randomized phased II study of neoadjuvant chemotherapy with or without an anti-EGFR monoclonal antibody for locally advanced, operable colon cancer. (2010) (1)
- Trainee led research networks in the implementation and delivery of multicentre randomised trials: a model from the west midlands research collaborative (2013) (1)
- Systematic review and meta‐analysis of randomized clinical trials of self‐expanding metallic stents as a bridge to surgery versus emergency surgery for malignant left‐sided large bowel obstruction (Br J Surg 2012; 99: 469–476) (2012) (1)
- OP002 Epigenetic biomarkers to detect ulcerative colitis-associated neoplasia: results from phase I of the ENDCAP-C study. (2017) (1)
- Surgical treatment of colorectal cancer (2006) (1)
- Comprar The Digestive System, 2nd Edition Systems of the Body Series | Margaret E. Smith | 9780702033674 | Churchill Livingstone (2010) (1)
- Extracolonic findings at CT colonography an a symptomatic population (oral abstract) (2005) (1)
- Screening and diagnosis of colorectal cancer (2012) (0)
- Comparison of Mutational Status in the EGFR Pathway Across Four Different Platforms in the Fluoropyrimidine Oxaliplatin and Targeted Receptor Pre-Operative Therapy (FOxTROT) Trial (2018) (0)
- Histopathological Downstaging of Colon Cancer Following Six Weeks of Pre-operative Chemotherapy: Early Results of the NCRI FOxTROT Trial (2012) (0)
- Diagnostic dilemmas Chronic pancreatitis andpancreatic (1997) (0)
- Biological mesh reinforcement of complex and contaminated midline laparotomy achieving fascial closure: A cross-sectional review of stage of innovation (2018) (0)
- Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy study (2021) (0)
- Lossoftheretinoblastoma susceptibility gene(RB1) isafrequent and early event inprostatic tumorigenesis (1994) (0)
- Interventional and Surgical Trials (2012) (0)
- The costs of surgical site infection after abdominal surgery in middle income countries: Key resource use In Wound Infection (KIWI) study. (2023) (0)
- Diagnostic dilemmas Chronic pancreatitis and pancreatic carcinoma (2003) (0)
- P062 The effect of steroids on expression of Wnt pathway inhibitors in patients with longstanding ulcerative colitis (2012) (0)
- Surgery for Fulminant Colitis (2012) (0)
- Patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies may inform prospective clinical trials (2018) (0)
- Predicting bowel cancer in chronic Ulcerative Colitis (2011) (0)
- sedimentation rate in an Asian woman Right iliac fossa mass with high erythrocyte (2017) (0)
- Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture (2022) (0)
- The effects on quality of life of a hernia at the site of stoma closure are unknown (2013) (0)
- 1035 POSTER Genome-wide Promoter and CpG Island DNA Methylation Screening Identifies Novel Prognostic Markers and Distinct Pathway in Rectal Cancer (2011) (0)
- Smoking and risk of colorectal polyps (1998) (0)
- Thirty-two year old Caucasian female with mass in the abdomen of two years duration. (1976) (0)
- Right iliac fossa mass with high erythrocyte sedimentation rate in an Asian woman (2008) (0)
- TheuseofDNA fromparaffin wax preserved tissue forpredictive diagnosis infamilial adenomatous polyposis (1992) (0)
- Preventing Recurrence of GI Cancer. Postgraduate Course held during the UEGW ’99, Rome, November 14, 1999 (2000) (0)
- A special look at advanced cancer. (2016) (0)
- and colorectal cancer suppressor gene in sporadic renal cell carcinoma ) tumour BHD Analysis of the Birt-Hogg-Dubé ( (2005) (0)
- Regulation of P-Cadherin Expression in the Colon (2002) (0)
- Allelic Deletion at 8p11.2‐p12 is Frequent in Head and Neck Cancer and Identifiable Using Fluorescence in‐situ Hybridisation on Tumour Imprints (2000) (0)
- Poor pain control in major gastrointestinal surgery (2016) (0)
- Global economic burden of unmet surgical need for appendicitis. (2022) (0)
- Adjuvant screening in familial adenomatous polyposis. (1993) (0)
- Systematic review of published and unpublished data on the incidence of incisional hernia following closure of abdominal wall stomas (2011) (0)
- A new standard for malignant pleural mesothelioma (2016) (0)
- Comparison of Mismatch Repair Protein Expression Between Biopsies and Resections in Advanced Colon Cancer from the Phase II Group of the Fluoropyrimidine Oxaliplatin and Targeted Receptor Pre-Operative Therapy (FOxTROT) Trial (2018) (0)
- Clinical resources and costs associated with the extracolonic findings at CTC: a retrospective study (abs) (2006) (0)
- Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta‐analysis (2018) (0)
- Edinburgh Research Explorer Somatic Cancer Genetics in the UK: Real-World Data from Phase One of the Cancer Research UK Stratified Medicine Programme (2018) (0)
- Deciphering the molecular signalling underpinning early-dissemination and metastasis from stage I colorectal cancer (2019) (0)
- Oestrogen metabolism by steroid sulphatase and 17[beta]-hydroxysteroid dehydrogenases promotes colorectal cancer proliferation via the G-protein coupled oestrogen receptor (2015) (0)
- Interstitial deletions on chromosome 8p in squamous cell carcinoma of the head and neck (1997) (0)
- Abstract 178:RASSF10is frequently methylated in epithelial cancers (2010) (0)
- Comparison of Mutational Calls Obtained with Pyrosequencing and the Affymetrix OncoScan (R) FFPE Assay in Patients with Colon Cancer Recruited to the NCRI FOxTROT Trial (2015) (0)
- Steroid sulphatase and G-protein coupled oestrogen receptor in human colorectal cancer: correlation with late-stage disease and potential therapeutic targets (2015) (0)
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Dion Morton is affiliated with the following schools:
