Dirk Görlich
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(Suggest an Edit or Addition)According to Wikipedia, Dirk Görlich, born October 18, 1966, in Halle of Germany, is a German biochemist. He is now director at the Max Planck Institute for Multidisciplinary Sciences in Göttingen. His research focuses on cellular logistics, the transport mechanism of proteins in cells between the nucleus and the cytoplasm. Görlich became a member of the German National Academy of Sciences Leopoldina in 2005. He is also a member of the European Molecular Biology Organization.
Dirk Görlich's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transport between the cell nucleus and the cytoplasm. (1999) (2050)
- Kinetic analysis of translocation through nuclear pore complexes (2001) (756)
- Isolation of a protein that is essential for the first step of nuclear protein import (1994) (705)
- Identification of different roles for RanGDP and RanGTP in nuclear protein import. (1996) (660)
- Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane (1993) (651)
- The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus (1997) (645)
- Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor (1997) (565)
- FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like Properties (2006) (561)
- The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion (2002) (528)
- Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope (1995) (512)
- NTF2 mediates nuclear import of Ran (1998) (475)
- Distinct functions for the two importin subunits in nuclear protein import (1995) (473)
- A Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore Complexes (2007) (469)
- A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation (1992) (432)
- A 41 amino acid motif in importin‐alpha confers binding to importin‐beta and hence transit into the nucleus. (1996) (428)
- A Novel Class of RanGTP Binding Proteins (1997) (421)
- Identification of a tRNA-specific nuclear export receptor. (1998) (386)
- Dominant‐negative mutants of importin‐β block multiple pathways of import and export through the nuclear pore complex (1997) (374)
- Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import (1999) (347)
- Transport into and out of the cell nucleus (1998) (346)
- The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. (2000) (334)
- Characterisation of the passive permeability barrier of nuclear pore complexes (2009) (325)
- Nuclear protein import. (1997) (320)
- Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution (1999) (312)
- Exportin 6: a novel nuclear export receptor that is specific for profilin·actin complexes (2003) (312)
- Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles. (2016) (302)
- Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. (1997) (297)
- Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains (2002) (289)
- A protein of the endoplasmic reticulum involved early in polypeptide translocation (1992) (286)
- Evolutionary conservation of components of the protein translocation complex (1994) (272)
- RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors (1997) (269)
- The Permeability of Reconstituted Nuclear Pores Provides Direct Evidence for the Selective Phase Model (2012) (258)
- Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm (2002) (240)
- The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1 (1999) (238)
- Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity (2015) (229)
- NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1 (2010) (225)
- Importin 13: a novel mediator of nuclear import and export (2001) (224)
- Characterization of Ran‐driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation (2003) (221)
- Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP (2009) (209)
- Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes (2000) (207)
- Ran‐dependent nuclear export mediators: a structural perspective (2011) (194)
- Importin Provides a Link between Nuclear Protein Import and U snRNA Export (1996) (193)
- Nuclear import of HIV‐1 intracellular reverse transcription complexes is mediated by importin 7 (2003) (193)
- Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex (1994) (191)
- CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm (1999) (186)
- Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes (2012) (181)
- Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. (1999) (179)
- Yrb4p, a yeast Ran–GTP‐binding protein involved in import of ribosomal protein L25 into the nucleus (1997) (170)
- A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes (2006) (170)
- Amyloid-like interactions within nucleoporin FG hydrogels (2010) (168)
- NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes (2006) (167)
- Acetylation of importin-α nuclear import factors by CBP/p300 (2000) (165)
- Nucleocytoplasmic Transport (1996) (163)
- Myelin Membrane Assembly Is Driven by a Phase Transition of Myelin Basic Proteins Into a Cohesive Protein Meshwork (2013) (161)
- Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation (2015) (160)
- A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning (2015) (156)
- A tetrameric complex of membrane proteins in the endoplasmic reticulum. (1993) (146)
- The translocation of transportin–cargo complexes through nuclear pores is independent of both Ran and energy (1999) (138)
- NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. (2006) (127)
- FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties (2009) (125)
- Coordination of tRNA nuclear export with processing of tRNA. (1999) (120)
- A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. (1996) (119)
- Structural view of the Ran-Importin beta interaction at 2.3 A resolution. (1999) (118)
- mediates nuclear export of pre-miRNAs Exportin 5 is a RanGTP-dependent dsRNA-binding protein that (2004) (118)
- A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins. (2014) (110)
- Ultrathin nucleoporin phenylalanine–glycine repeat films and their interaction with nuclear transport receptors (2010) (109)
- Caspases mediate nucleoporin cleavage, but not early redistribution of nuclear transport factors and modulation of nuclear permeability in apoptosis (2001) (108)
- Exportin 7 defines a novel general nuclear export pathway (2004) (106)
- Surface Properties Determining Passage Rates of Proteins through Nuclear Pores (2018) (100)
- The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER (1991) (100)
- Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors (2009) (98)
- Crystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complex (2015) (91)
- Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1 (1997) (90)
- Strong signal increase in STED fluorescence microscopy by imaging regions of subdiffraction extent (2017) (89)
- The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents (1990) (88)
- A toolbox of anti–mouse and anti–rabbit IgG secondary nanobodies (2018) (84)
- Import of DNA into mammalian nuclei by proteins originating from a plant pathogenic bacterium. (1999) (83)
- Acetylation of importin-alpha nuclear import factors by CBP/p300. (2000) (82)
- Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. (2005) (79)
- Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells (2006) (72)
- The Sec61 complex is essential for the insertion of proteins into the membrane of the endoplasmic reticulum (1995) (71)
- Inducible expression of coding and inhibitory RNAs from retargetable genomic loci (2009) (71)
- Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7. (2009) (69)
- The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis (2013) (66)
- A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies (2016) (64)
- Structural analysis of large protein complexes using solvent paramagnetic relaxation enhancements. (2011) (63)
- Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPα but not importin α (1999) (62)
- Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (2001) (61)
- Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta. (2000) (60)
- The Ketel gene encodes a Drosophila homologue of importin-beta. (2000) (55)
- Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. (2014) (50)
- Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies (2021) (49)
- Purification of protein complexes of defined subunit stoichiometry using a set of orthogonal, tag-cleaving proteases. (2014) (48)
- Identification of Two Novel RanGTP-binding Proteins Belonging to the Importin β Superfamily* (2000) (47)
- Adenoviral E1A protein nuclear import is preferentially mediated by importin alpha3 in vitro. (2001) (45)
- F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis (2020) (44)
- Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks - Implications for nuclear pore permeability. (2013) (43)
- Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A (2016) (39)
- Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane. (1990) (37)
- Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment (2016) (35)
- Xpo7 is a broad-spectrum exportin and a nuclear import receptor (2018) (31)
- Regulatory roles of the nuclear envelope. (1996) (29)
- Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha. (1999) (27)
- A Ran-binding motif in nuclear pore proteins. (1995) (26)
- Probing the molecular environment of translocating polypeptide chains by cross-linking. (1991) (25)
- Structural characterization of nanoscale meshworks within a nucleoporin FG hydrogel. (2012) (25)
- Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics (2018) (22)
- The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models (2020) (22)
- Reversible Immobilization of Proteins in Sensors and Solid-State Nanopores. (2018) (22)
- Correction: Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation (2016) (21)
- Roles of importin in nuclear protein import. (1995) (19)
- Engineered SUMO/protease system identifies Pdr6 as a bidirectional nuclear transport receptor (2019) (14)
- Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP (2022) (12)
- Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide (2021) (12)
- Importin β , transportin , RanBP 5 and RanBP 7 mediate nuclear import of ribosomal proteins in mammalian cells (2013) (11)
- Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains (2022) (10)
- Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122 (2019) (8)
- A simple thermodynamic description of phase separation of Nup98 FG domains (2022) (8)
- The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts (2015) (7)
- N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication (2021) (7)
- Ultrathin nucleoporin FG repeat films and their interaction with nuclear transport receptors (2010) (6)
- Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles (2022) (4)
- Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic (2022) (3)
- Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length (2022) (3)
- The supramolecular assembly of intrinsically disordered nucleoporin domains is tuned by inter-chain interactions. (2013) (3)
- Author response: A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning (2015) (3)
- Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication (2022) (3)
- Identification of Two Novel RanGTP-binding Proteins Belonging to the Importin b Superfamily* (2000) (3)
- A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins (2022) (2)
- Structure of the metazoan Nup62.Nup58.Nup54 nucleoporin complex. (2015) (2)
- Editorial Overview: Functional and Mechanistic Landscape of the Nuclear Pore Complex. (2016) (2)
- A Method to Quantify Molecular Diffusion within Thin Solvated Polymer Films: A Case Study on Films of Natively Unfolded Nucleoporins (2020) (2)
- The copper(II)-binding tripeptide GHK, a valuable crystallization and phasing tag for macromolecular crystallography (2020) (1)
- Components and mechanism of protein translocation across the ER membrane (1992) (1)
- Interactors of Sox2 in embryonic stem cells. (2008) (1)
- Engineering nanobodies for super-resolution imaging and native protein complex isolation. (2016) (0)
- The exportin Xpo4 recognizes eIF5A through its unique amino acid hypusine for nuclear export. (2016) (0)
- Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II) (2010) (0)
- Recapitulation of nucleocytoplasmic transport with phase-separation of engineered protein repeats. (2019) (0)
- Crystal structure of the biportin Pdr6 in complex with RanGTP (2019) (0)
- Transport in and out of the cell nucleus (2000) (0)
- Mechanical characterization of phase separated FG particles using Atomic Force Microscopy techniques. (2017) (0)
- A genetic system to probe how intrinsically disordered FG domains form the permeability barrier of NPCs. (2014) (0)
- Exploring the complete spectrum of CRM1 cargoes. (2014) (0)
- Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl (2005) (0)
- Thesis committee members (2014) (0)
- Crystal structure of RanGTP-Exportin 4-eIF5A complex (2016) (0)
- Structural basis for CRM1 nuclear export complex assembly (2010) (0)
- Structure of Lph2 , a novel bidirectional nuclear transport receptor in S. cerevisiae (2019) (0)
- Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex (2010) (0)
- Author response: Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity (2014) (0)
- DEVELOPMANTAL AND MOLECULAR GENETICS OF KETEL, THE DROSOPHILA HOMOLOGUE OF IMPORTIN-p (2019) (0)
- ROLES OF IMPORTIN IN NUCLEOCYTOPLASMIC TRANSPORT (1996) (0)
- NDC1 is a crucial membrane-integral nucleoporin of metazoa (2007) (0)
- Crystal structure of the CRM1-RanGTP complex (2010) (0)
- Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins (2022) (0)
- Novel types of interactions of the small GTPase Ran with its effectors (2000) (0)
- Delft University of Technology Reversible Immobilization of Proteins in Sensors and Solid-State Nanopores (2018) (0)
- RNA: Reviewers for Volume 21, 2015. (2015) (0)
- Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains (2022) (0)
- Ferredoxin-like domain of nucleoporin Nup54 bound to a nanobody (2015) (0)
- Erythroid-Specific Variant of the Nuclear Exportin Xpo7 Conserved Only in Mammals May Explain Functional Differences Between Mammalian Definitive and Lower Vertebrate (or Primitive) Erythropoiesis (2016) (0)
- Using immobilized chelants for purification of recombinant proteins by immobilized metal ion chromatography and purification method of recombinant proteins (2008) (0)
- protein complex isolation Nanobodies : site-specific labeling for super-resolution imaging , rapid epitope-mapping and native Böhning (2015) (0)
- Author response: A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies (2016) (0)
- Functional principles of the permeability barrier that guards vertebrate nuclear pore complexes. (2012) (0)
- Nucleus and gene expression. (2001) (0)
- Crystal structure of Nup62.58.54 nucleoporin complex. (2014) (0)
- Mechanical characterization of phase separated nucleoporin droplets using Atomic Force Microscopy techniques. (2019) (0)
- Components and Mechanisms Involved in Protein Translocation Through the ER Membrane (1994) (0)
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