Dirk Schübeler
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German geneticist
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Why Is Dirk Schübeler Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dirk Schübeler is a German researcher, Director of the Friedrich Miescher Institute for Biomedical Research and professor at the University of Basel. He is an expert in gene regulation. Education and career Dirk Schübeler obtained his PhD from the Technical University in Braunschweig, Germany working in the Helmholtz Center for Infectious Research in the group of Jürgen Bode. He then did postdoctoral studies at the Fred Hutchinson Cancer Research Center in Seattle, USA, working with Mark Groudine. Schübeler joined the Friedrich Miescher Institute of Biomedical Research in 2003 as a junior group leader, in 2008 he was appointed senior group leader, and in 2011 he became adjunct professor at the University of Basel. In April 2020 he was appointed Director of the FMI. Since January 2021, Dirk Schübeler has been Full Professor of Molecular Biology at the University of Basel.
Dirk Schübeler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome (2007) (2091)
- Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells (2005) (1780)
- Function and information content of DNA methylation (2015) (1504)
- DNA-binding factors shape the mouse methylome at distal regulatory regions (2011) (1205)
- Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008) (891)
- The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. (2004) (854)
- Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017) (736)
- Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010) (611)
- Targets and dynamics of promoter DNA methylation during early mouse development (2010) (561)
- Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation (2015) (518)
- Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation (2008) (515)
- Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs (2010) (462)
- Determinants and dynamics of genome accessibility (2011) (453)
- Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. (2013) (408)
- Identification of genetic elements that autonomously determine DNA methylation states (2011) (384)
- Genomic patterns of DNA methylation: targets and function of an epigenetic mark. (2007) (383)
- Competition between DNA methylation and transcription factors determines binding of NRF1 (2015) (366)
- The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (2016) (360)
- Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing (2002) (350)
- Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. (2000) (334)
- BLUEPRINT to decode the epigenetic signature written in blood (2012) (320)
- Methylation-Dependent and -Independent Genomic Targeting Principles of the MBD Protein Family (2013) (318)
- Nuclear compartmentalization and gene activity (2000) (301)
- Genetics and epigenetics: stability and plasticity during cellular differentiation. (2009) (292)
- Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa (2013) (283)
- YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers (2015) (275)
- Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease (2014) (250)
- DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity (2008) (247)
- Methylated DNA immunoprecipitation (MeDIP). (2009) (223)
- PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping (2008) (205)
- Genomation: a Toolkit to Summarize, Annotate and Visualize Genomic Intervals (2015) (199)
- Transcription Factor Occupancy Can Mediate Active Turnover of DNA Methylation at Regulatory Regions (2013) (198)
- A Complex Chromatin Landscape Revealed by Patterns of Nuclease Sensitivity and Histone Modification within the Mouse β-Globin Locus (2003) (192)
- Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. (2005) (188)
- Genomic Targeting of Methylated DNA: Influence of Methylation on Transcription, Replication, Chromatin Structure, and Histone Acetylation (2000) (183)
- Identification of active regulatory regions from DNA methylation data (2013) (179)
- Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila (2007) (176)
- DNA methylation is required for the control of stem cell differentiation in the small intestine (2014) (169)
- Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function. (2015) (164)
- Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. (2009) (156)
- New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. (2009) (151)
- Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa. (2009) (142)
- DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. (2004) (138)
- Methylation of histones: playing memory with DNA. (2005) (137)
- Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state (2012) (136)
- Epigenomics: Mapping the Methylome (2006) (132)
- H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming (2009) (131)
- Genomic patterns and context specific interpretation of DNA methylation. (2014) (131)
- Genome-wide Single-Molecule Footprinting Reveals High RNA Polymerase II Turnover at Paused Promoters (2017) (129)
- Dynamic Analysis of Proviral Induction and De Novo Methylation: Implications for a Histone Deacetylase-Independent, Methylation Density-Dependent Mechanism of Transcriptional Repression (2000) (129)
- Genomic Prevalence of Heterochromatic H3K9me2 and Transcription Do Not Discriminate Pluripotent from Terminally Differentiated Cells (2011) (129)
- A chromatin-modifying function of JNK during stem cell differentiation (2011) (125)
- Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors (2019) (124)
- Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation (2014) (122)
- DNA Methylation Density Influences the Stability of an Epigenetic Imprint and Dnmt3a/b-Independent De Novo Methylation (2002) (122)
- Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans (2018) (121)
- Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting (2013) (121)
- Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region (2000) (120)
- Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing (2010) (119)
- DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs. (1998) (108)
- Methylation-Mediated Proviral Silencing Is Associated with MeCP2 Recruitment and Localized Histone H3 Deacetylation (2001) (107)
- Ezh2 is required for neural crest-derived cartilage and bone formation (2014) (99)
- Scaffold/matrix-attached regions act upon transcription in a context-dependent manner. (1996) (96)
- Mechanisms of OCT4-SOX2 motif readout on nucleosomes (2020) (90)
- The murine β-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes (2001) (88)
- The Transgeneticists Toolbox: Novel Methods for the Targeted Modification of Eukaryotic Genomes (2000) (88)
- Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome (2012) (87)
- ChIPs of the β-globin locus: unraveling gene regulation within an active domain (2002) (87)
- Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming. (2016) (84)
- Tackling the epigenome: challenges and opportunities for collaboration (2010) (84)
- Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome. (2010) (81)
- Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice (2011) (81)
- Transcription-Coupled Methylation of Histone H3 at Lysine 36 Regulates Dosage Compensation by Enhancing Recruitment of the MSL Complex in Drosophila melanogaster (2008) (79)
- A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity (2020) (78)
- A question of timing: emerging links between transcription and replication. (2006) (74)
- Gene regulation and priming by topoisomerase IIα in embryonic stem cells (2013) (71)
- High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions (2014) (69)
- Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion. (2013) (67)
- DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes (2014) (66)
- Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape (2018) (65)
- DNA damage detection in nucleosomes involves DNA register shifting (2019) (62)
- Mammalian SWI/SNF continuously restores local accessibility to chromatin (2021) (62)
- Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation (2013) (62)
- Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels (2012) (57)
- Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo. (2020) (46)
- Stabilized, long-term expression of heterodimeric proteins from tricistronic mRNA. (2000) (45)
- ChIPs of the beta-globin locus: unraveling gene regulation within an active domain. (2002) (45)
- Epigenetic Islands in a Genetic Ocean (2012) (43)
- CG dinucleotides enhance promoter activity independent of DNA methylation (2019) (41)
- Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation (2015) (37)
- Cis-regulatory landscapes of four cell types of the retina (2017) (30)
- BANP opens chromatin and activates CpG-island-regulated genes (2021) (29)
- Retargeting of retroviral integration sites for the predictable expression of transgenes and the analysis of cis-acting sequences. (1998) (28)
- Transcriptional properties of genomic transgene integration sites marked by electroporation or retroviral infection. (2000) (27)
- Evidence for Converging DNA Methylation Pathways in Placenta and Cancer. (2017) (27)
- Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization (2017) (24)
- Epigenomics: Methylation matters (2009) (22)
- Ezh 2 is required for neural crest-derived cartilage and bone formation (21)
- PAX8 and MECOM are interaction partners driving ovarian cancer (2021) (20)
- Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens (2021) (14)
- Defining epigenetic states through chromatin and RNA (2005) (14)
- RNA Polymerase II: Just Stopping By (2007) (12)
- Binding of high mobility group A proteins to the mammalian genome occurs as a function of AT-content (2017) (12)
- monaLisa: an R/Bioconductor package for identifying regulatory motifs (2021) (12)
- A sensitive transcription assay based on a simplified nuclear runon protocol (1997) (11)
- Generating specificity in genome regulation through transcription factor sensitivity to chromatin (2022) (11)
- ESCI award lecture: regulation, function and biomarker potential of DNA methylation (2015) (10)
- Corrigendum: DNA-binding factors shape the mouse methylome at distal regulatory regions (2012) (10)
- A New Map for Navigating the Yeast Epigenome (2005) (9)
- Dosage compensation in high resolution: global up-regulation through local recruitment. (2006) (9)
- Enhancing genome annotation with chromatin (2007) (8)
- Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation (2022) (8)
- Lineage-specific Polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors (2008) (8)
- Chromatin: Sub Out the Replacement (2009) (7)
- Tracking the evolution of cancer methylomes (2012) (6)
- Single molecule occupancy patterns of transcription factors reveal determinants of cooperative binding in vivo (2020) (5)
- Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions (1999) (4)
- Chromatin in Multicolor (2010) (4)
- Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing - Supplemental data. (2002) (4)
- DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions (2022) (2)
- Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors (2019) (2)
- Author response: High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions (2014) (2)
- Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa (2013) (2)
- Methylation of histones: playing memory with DNA (Curr. Opin. Cell Biol. 17 (2005) 230) § (2005) (1)
- ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes (2021) (1)
- Twisting chromatin in stem cells (2013) (1)
- Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting (2019) (1)
- Non-mendelian Inheritance in Mammals Is Highly Constrained (2018) (1)
- ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers (2023) (1)
- Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome (2012) (0)
- A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity (2020) (0)
- Faculty Opinions recommendation of Systematic Study of Nucleosome-Displacing Factors in Budding Yeast. (2018) (0)
- Foreword: From genetic diversity to chromosomal biology: an array of tasks beyond expression (2005) (0)
- Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape (2018) (0)
- DNA damage detection in nucleosomes involves DNA register shifting (2019) (0)
- Report on the ESF exploratory workshop EW06-069 ”Computational approaches to the role of epigenetic marks in transcription regulation” (2008) (0)
- Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting (2019) (0)
- Aging-Dependent Demeth ylation of Regulatory Elements Correlates with Chromatin State and Improved b Cell Function Graphical (0)
- Christiane melanogaster Drosophila of the MSL Complex in Compensation by Enhancing Recruitment Histone H 3 at Lysine 36 Regulates Dosage Transcription-Coupled Methylation of (2008) (0)
- Faculty Opinions recommendation of Animal transcription networks as highly connected, quantitative continua. (2011) (0)
- Author Correction: H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming (2018) (0)
- Faculty of 1000 evaluation for Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors. (2018) (0)
- Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation (2015) (0)
- VRG Program Evaluation 2021. Report by the International Review Panel. (2022) (0)
- Readout of histone methylation by Trim24 locally restricts chromatin opening by p53 (2022) (0)
- Kobe University Repository : Kernel タイトル Tit le DNA damage detect ion in nucleosomes involves DNA register shift (2020) (0)
- Genome-wide analysis of DNA methylation profiles in a preclinical animal model of non-genotoxic carcinogenesis☆ (2009) (0)
- Growth of noble fir (Abies procera) in northwest Germany. (1990) (0)
- – REPORT BY THE INTERNATIONAL REVIEW PANEL (2022) (0)
- Neurospora crassa formation in Relics of repeat-induced point mutation direct heterochromatin Material Supplemental (2009) (0)
- Topoisomerase IIβ binding to promoters in postmitotic cells modulates gene activity and regulates neuronal survival. (2012) (0)
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