Dirkje Postma

Q: What Schools Are Affiliated With Dirkje Postma

Dirkje Postma is affiliated with the following schools: Ghent University, University of Amsterdam, Utrecht University, University of Groningen, Eindhoven University of Technology, Delft University of Technology

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Dirkje Postma

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#2892

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#414

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#434

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Computer Science

Dirkje Postma's Degrees

PhD Computer Science Delft University of Technology
Masters Computer Science Eindhoven University of Technology
Bachelors Computer Science Eindhoven University of Technology

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Why Is Dirkje Postma Influential?

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According to Wikipedia, Dirkje Postma is professor at the University of Groningen and the University Medical Center Groningen. She focused her research career on asthma and COPD. Postma is a member of the Health Council of the Netherlands.

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Dirkje Postma's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Chronic obstructive pulmonary disease. (2002) (3787)
Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. (1995) (1609)
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. (1997) (1536)
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. (2010) (844)
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction (2009) (790)
Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. (1995) (773)
The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma (2003) (750)
Development, validity and responsiveness of the Clinical COPD Questionnaire (2003) (749)
Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking (1999) (694)
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. (2016) (627)
Air pollution and development of asthma, allergy and infections in a birth cohort (2007) (552)
Acute effects of cigarette smoke on inflammation and oxidative stress: a review (2004) (550)
Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche (2014) (511)
Ambient air pollution and low birthweight: a European cohort study (ESCAPE). (2013) (505)
The Asthma-COPD Overlap Syndrome. (2015) (500)
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. (2003) (499)
Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. (2011) (420)
Risk factors and early origins of chronic obstructive pulmonary disease (2015) (404)
Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function (2011) (401)
Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. (1994) (397)
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. (2016) (383)
Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. (1999) (378)
Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. (1999) (378)
A genome-wide association meta-analysis identifies new childhood obesity loci (2012) (375)
Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. (1999) (359)
Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis (2015) (356)
A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. Dutch Chronic Non-Specific Lung Disease Study Group. (1992) (353)
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. (2002) (352)
A comparison between an outpatient hospital-based pulmonary rehabilitation program and a home-care pulmonary rehabilitation program in patients with COPD. A follow-up of 18 months. (1996) (351)
Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins. (2009) (340)
Cigarette smoke-induced emphysema: A role for the B cell? (2006) (337)
Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks (2017) (337)
Gender and chronic obstructive pulmonary disease: why it matters. (2007) (333)
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank (2015) (326)
META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES IDENTIFIES THREE NEW RISK LOCI FOR ATOPIC DERMATITIS (2011) (325)
The Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study: Design and first results (2002) (324)
Ongoing airway inflammation in patients with COPD who do not currently smoke (1999) (323)
Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. (2011) (320)
Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers (2005) (314)
Gender differences in asthma development and progression. (2007) (301)
Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma (2012) (300)
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism (2012) (300)
Decline of FEV1 by age and smoking status: facts, figures, and fallacies. (1997) (295)
Severe exacerbations predict excess lung function decline in asthma (2007) (295)
Pulmonary biomarkers in chronic obstructive pulmonary disease. (2006) (294)
Prevalence of nutritional depletion in a large out-patient population of patients with COPD. (2006) (276)
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis (2017) (275)
Association of a promoter polymorphism of the CD14 gene and atopy. (2001) (261)
Remodeling in asthma and chronic obstructive pulmonary disease. (2006) (260)
Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. (2001) (260)
Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial (2005) (258)
Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. (2014) (253)
Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. (2015) (251)
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight (2010) (250)
Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease (2005) (247)
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. (2016) (245)
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization (2013) (236)
Asthma (2015) (232)
Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. (2005) (230)
Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up. (2003) (227)
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. (2012) (224)
Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study (2000) (222)
Quality of life in patients with chronic obstructive pulmonary disease improves after rehabilitation at home (1994) (220)
European Respiratory Society study on chronic obstructive pulmonary disease (EUROSCOP): hypothesis and design. (1992) (219)
Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. (2007) (216)
Female mice are more susceptible to the development of allergic airway inflammation than male mice (2005) (213)
Effect of ADRB2 polymorphisms on response to longacting β2-agonist therapy: a pharmacogenetic analysis of two randomised studies (2007) (208)
Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. (2003) (206)
Interpretation of bronchodilator response in patients with obstructive airways disease. The Dutch Chronic Non-Specific Lung Disease (CNSLD) Study Group. (1992) (205)
Universal risk factors for multifactorial diseases (2007) (205)
Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. (2001) (204)
Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. (1998) (204)
Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. (2009) (203)
Gender differences in asthma development and remission during transition through puberty: the TRacking Adolescents' Individual Lives Survey (TRAILS) study. (2010) (203)
Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex (2005) (202)
Genome-wide search for atopy susceptibility genes in Dutch families with asthma. (2002) (200)
Prognosis of asthma from childhood to adulthood. (1989) (198)
Universal risk factors for multifactorial diseases-LifeLines : a three-generation population-based study (2008) (197)
ATP-binding cassette (ABC) transporters in normal and pathological lung (2005) (195)
Reliability and validity of the chronic respiratory questionnaire (CRQ). (1994) (193)
Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study. (1999) (191)
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012) (187)
Does early indoor microbial exposure reduce the risk of asthma? The Prevention and Incidence of Asthma and Mite Allergy birth cohort study. (2006) (185)
The many faces of airway inflammation. Asthma and chronic obstructive pulmonary disease. Asthma Research Group. (1999) (184)
Cigarette smoke impairs airway epithelial barrier function and cell–cell contact recovery (2011) (184)
Small airway disease in asthma and COPD: clinical implications. (2011) (183)
Asthma at 8 years of age in children born by caesarean section (2008) (182)
Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response (2012) (180)
Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study. (2015) (180)
MACVIA‐ARIA Sentinel NetworK for allergic rhinitis (MASK‐rhinitis): the new generation guideline implementation (2015) (178)
Adult patients may outgrow their asthma: a 25-year follow-up study. (1997) (177)
Effects of long-term treatment with corticosteroids in COPD. (1996) (177)
E-cadherin: gatekeeper of airway mucosa and allergic sensitization. (2011) (176)
Are there reasons why adult asthma is more common in females? (2007) (175)
Major genes regulating total serum immunoglobulin E levels in families with asthma. (2000) (171)
Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis (1999) (169)
Relation between duration of smoking cessation and bronchial inflammation in COPD (2005) (169)
Effects of ambient air pollution on upper and lower respiratory symptoms and peak expiratory flow in children (1999) (168)
Multidrug resistance related molecules in human and murine lung. (2002) (168)
Comparison of formoterol and terbutaline for as-needed treatment of asthma: a randomised trial (2001) (167)
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function (2012) (167)
The Dutch hypothesis (chronic non-specific lung disease) revisited. (1991) (166)
MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine (2011) (166)
Gender differences in the management and experience of Chronic Obstructive Pulmonary Disease. (2004) (161)
Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. (2014) (159)
Increased systemic inflammation is a risk factor for COPD exacerbations. (2008) (157)
Genetics (AAGC) (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. (2015) (157)
Apocynin inhibits peroxynitrite formation by murine macrophages (2000) (157)
Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure (2016) (156)
Integrated care pathways for airway diseases (AIRWAYS-ICPs) (2014) (155)
More alternative activation of macrophages in lungs of asthmatic patients. (2011) (154)
Down-Regulation of E-Cadherin in Human Bronchial Epithelial Cells Leads to Epidermal Growth Factor Receptor-Dependent Th2 Cell-Promoting Activity1 (2007) (154)
CT-quantified emphysema in male heavy smokers: association with lung function decline (2011) (152)
Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. (2009) (152)
Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years. (2005) (151)
Independent influence of reversibility of air-flow obstruction and nonspecific hyperreactivity on the long-term course of lung function in chronic air-flow obstruction. (1986) (151)
Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review. (2013) (150)
Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. (2009) (149)
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study (2007) (148)
Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes (2017) (147)
A Disintegrin and Metalloprotease 33 polymorphisms and lung function decline in the general population (2006) (147)
A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo. (2007) (147)
Cognitive performance in patients with COPD. (2004) (144)
Characterisation of cell adhesion in airway epithelial cell types using electric cell–substrate impedance sensing (2009) (144)
Cohort profile: the prevention and incidence of asthma and mite allergy (PIAMA) birth cohort. (2014) (143)
Genome-wide association analysis identifies six new loci associated with forced vital capacity (2014) (141)
House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. (2010) (140)
Childhood factors associated with asthma remission after 30 year follow up (2004) (139)
Quality of life in patients with chronic obstructive pulmonary disease improves after rehabilitation at home. (1995) (138)
Acute effects of cigarette smoking on inflammation in healthy intermittent smokers (2005) (138)
Common and different genetic background for rheumatoid arthritis and coeliac disease. (2009) (138)
A sequence variant on 17q21 is associated with age at onset and severity of asthma (2010) (137)
A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. (2013) (136)
A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project (2014) (135)
Ambient air pollution, lung function, and airway responsiveness in asthmatic children. (2016) (135)
Asthma quality of life during 1 year of treatment with budesonide with or without formoterol. (1999) (135)
Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease (2011) (134)
Asthma and chronic obstructive pulmonary disease: common genes, common environments? (2011) (134)
REVERSIBILITY OF AIR-FLOW OBSTRUCTION (1988) (133)
Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. (2004) (133)
Meta-analysis identifies seven susceptibility loci involved in the atopic march (2015) (133)
Bronchial responsiveness to adenosine 5'-monophosphate (AMP) and methacholine differ in their relationship with airway allergy and baseline FEV(1). (2002) (132)
Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study. (2007) (127)
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. (2009) (127)
Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. (2005) (126)
Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma (2010) (126)
Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic air-flow obstruction. (1988) (125)
Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease (1999) (125)
ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle (2016) (124)
Clinical Investigations: COPDDetrimental Effects of β-Blockers in COPD: A Concern for Nonselective β-Blockers (2005) (123)
Effects of inhaled fluticasone and oral prednisolone on clinical and inflammatory parameters in patients with asthma (1999) (122)
Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. (2009) (122)
Molecular signature of smoking in human lung tissues. (2012) (120)
Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening. (2001) (120)
Predicting who will have asthma at school age among preschool children. (2012) (118)
Rationale for the Dutch hypothesis. Allergy and airway hyperresponsiveness as genetic factors and their interaction with environment in the development of asthma and COPD. (2004) (118)
Bronchiolitis obliterans syndrome after lung transplantation and health-related quality of life. (2000) (118)
A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK (2012) (117)
Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure (2009) (117)
Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis. (2006) (116)
Physiotherapy and bronchial mucus transport. (1999) (116)
The importance of genetic influences in asthma. (1999) (116)
A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. (2005) (115)
Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene (2012) (114)
Genome-wide association study of lung function decline in adults with and without asthma. (2012) (113)
Moderately severe chronic airflow obstruction. Can corticosteroids slow down obstruction? (1988) (112)
A novel common variant in DCST2 is associated with length in early life and height in adulthood (2014) (112)
Ciclesonide improves measures of small airway involvement in asthma (2008) (111)
Particulate Matter Composition and Respiratory Health: The PIAMA Birth Cohort Study (2015) (110)
Elevated serum interferon-gamma in atopic asthma correlates with increased airways responsiveness and circadian peak expiratory flow variation. (1998) (110)
Perimenstrual asthma: a syndrome without known cause or cure. (2003) (109)
Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype. (1998) (109)
Integrating real-life studies in the global therapeutic research framework. (2013) (109)
No effects of high-dose omeprazole in patients with severe airway hyperresponsiveness and (a)symptomatic gastro-oesophageal reflux. (1998) (109)
Airway epithelial changes in smokers but not in ex-smokers with asthma. (2009) (108)
Increased number of B-cells in bronchial biopsies in COPD (2006) (108)
Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function. (1997) (106)
Airway responsiveness to adenosine 5'-monophosphate in chronic obstructive pulmonary disease is determined by smoking. (1993) (106)
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. (2010) (106)
A systematic review of the effects of bronchodilators on exercise capacity in patients with COPD. (2002) (105)
Maternal smoking during pregnancy induces airway remodelling in mice offspring (2009) (105)
Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. (2002) (104)
Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study (2007) (103)
Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice. (2004) (103)
Risk factors for atopic dermatitis in infants at high risk of allergy: the PIAMA study (2003) (102)
Ongoing airway inflammation in patients with COPD who do not currently smoke. (2000) (102)
Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study. (2019) (101)
Influence of the parasympathetic and sympathetic nervous system on nocturnal bronchial obstruction. (1985) (101)
Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation (2009) (99)
Elicitation of allergic asthma by immunoglobulin free light chains. (2005) (99)
Prognosis of chronic obstructive pulmonary disease: the Dutch experience. (1989) (98)
Asthma attacks with eosinophilia predict mortality from chronic obstructive pulmonary disease in a general population sample. (1999) (98)
Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers. (2005) (98)
Relationship of airway hyperresponsiveness to respiratory symptoms and diurnal peak flow variation in patients with obstructive lung disease. The Dutch CNSLD Study Group. (1991) (98)
and oxidative stress: a review Acute effects of cigarette smoke on inflammation (2005) (97)
Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids. (2014) (97)
Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease (2013) (96)
A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD (2014) (96)
Severe chronic airflow obstruction: can corticosteroids slow down progression? (1985) (95)
Tobacco use in relation to COPD and asthma (2007) (95)
Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA2LEN – ARIA Position Paper (2012) (93)
Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The MeDALL hypothesis (2015) (93)
Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. (2013) (93)
Airways hyperresponsiveness, bronchodilator response, allergy and smoking predict improvement in FEV1 during long-term inhaled corticosteroid treatment. Dutch CNSLD Study Group. (1993) (93)
Perception of airway obstruction in a random population sample. Relationship to airway hyperresponsiveness in the absence of respiratory symptoms. (1992) (93)
Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? The Dutch CNSLD Study Group. The Dutch Chronic Nonspecific Lung Disease Study Groups. (1996) (93)
Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma (2010) (92)
Influence of treatment on peak expiratory flow and its relation to airway hyperresponsiveness and symptoms. The Dutch CNSLD Study Group. (1994) (92)
Evidence for two unlinked loci regulating total serum IgE levels. (1995) (92)
Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema. (1999) (92)
Genome‐Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow‐up (2017) (91)
Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis (2006) (91)
Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. (2000) (89)
Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscop study. (2006) (88)
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. (2014) (88)
TLR‐related pathway analysis: novel gene–gene interactions in the development of asthma and atopy (2010) (88)
Expression of ADAMs (“a disintegrin and metalloprotease”) in the human lung (2009) (87)
Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy (2005) (86)
Airway Inflammation and Remodeling in Two Mouse Models of Asthma: Comparison of Males and Females (2010) (86)
Role and interpretation of total serum IgE measurements in the diagnosis of allergic airway disease in adults (2003) (86)
Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD (2011) (85)
Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. (2008) (85)
Phenotyping asthma, rhinitis and eczema in MeDALL population‐based birth cohorts: an allergic comorbidity cluster (2015) (84)
Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma. (2006) (84)
Effects of inhaled budesonide on spirometric values, reversibility, airway responsiveness, and cough threshold in smokers with chronic obstructive lung disease. (1991) (84)
Genetic and environment in asthma: the answer of twin studies. (1999) (84)
Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD (2000) (83)
Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. (2012) (82)
Altered expression of the Smad signalling pathway: implications for COPD pathogenesis (2006) (82)
Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p (1992) (82)
Characterization of obstructive airway disease in family members of probands with asthma. An algorithm for the diagnosis of asthma. (1998) (81)
PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. (2009) (81)
Heritability of Self-Reported Asthma and Allergy: A Study in Adult Dutch Twins, Siblings and Parents (2008) (80)
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story (2016) (80)
Fluticasone propionate, salmeterol xinafoate, and their combination in the treatment of nocturnal asthma. (1997) (80)
GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study (2014) (80)
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and β2 agonist and steroid response (2010) (80)
Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD (2007) (80)
Identifying Risk of Future Asthma Attacks Using UK Medical Record Data: A Respiratory Effectiveness Group Initiative. (2017) (80)
Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial (2013) (80)
First study of infliximab treatment in patients with chronic obstructive pulmonary disease. (2005) (79)
Pesticides and other occupational exposures are associated with airway obstruction: the LifeLines cohort study (2013) (79)
Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study (2008) (79)
Prognosis in severe chronic obstructive pulmonary disease. (1979) (78)
The relationship of skin test positivity, high serum total IgE levels, and peripheral blood eosinophilia to symptomatic and asymptomatic airway hyperresponsiveness. (1999) (78)
Quality-of-life in a long-term multicentre trial in chronic nonspecific lung disease: assessment at baseline. The Dutch CNSLD Study Group. (1993) (78)
Operational definition of Active and Healthy Ageing (AHA): A conceptual framework (2015) (77)
Airways inflammation and treatment during acute exacerbations of COPD (2008) (77)
IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms. (1996) (77)
Maternal overweight before pregnancy and asthma in offspring followed for 8 years (2010) (76)
Association of Forced Vital Capacity with the Developmental Gene NCOR2 (2016) (76)
Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity (2013) (76)
Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. (2013) (76)
AIRWAYS HYPERRESPONSIVENESS, BRONCHODILATOR RESPONSE, ALLERGY AND SMOKING PREDICT IMPROVEMENT IN FEV(1) DURING LONG-TERM INHALED CORTICOSTEROID TREATMENT (1993) (75)
Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma. (2011) (74)
Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. (2011) (74)
A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology (2006) (74)
Unravelling the complexity of COPD by microRNAs: it's a small world after all (2015) (74)
Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD (2008) (73)
Revisiting the Dutch hypothesis. (2015) (73)
Treatment of the bronchial tree from beginning to end: targeting small airway inflammation in asthma (2013) (72)
Reticular basement membrane in asthma and COPD: Similar thickness, yet different composition (2009) (72)
Caveolin-1 controls airway epithelial barrier function. Implications for asthma. (2013) (72)
Asthma and chronic obstructive pulmonary disease: similarities and differences. (2014) (72)
Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes. (2008) (71)
Role of serum cortisol levels in children with asthma. (2002) (71)
Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells. (2005) (71)
Molecular mechanisms underlying variations in lung function: a systems genetics analysis. (2015) (71)
Blood eosinophil count and exacerbation risk in patients with COPD (2017) (71)
Blood eosinophil numbers and activity during 24 hours: effects of treatment with budesonide and bambuterol. (1992) (70)
LONG-TERM OUTCOME OF LUNG TRANSPLANTATION IS PREDICTED BY THE NUMBER OF HLA-DR MISMATCHES (2001) (70)
Current smoking‐specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer (2009) (70)
Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease. (2014) (70)
Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls (2013) (70)
Airway Remodeling in the Smoke Exposed Guinea Pig Model (2007) (69)
Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers (2005) (69)
Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study (2018) (69)
Interleukin‐6 promotes the production of interleukin‐4 and interleukin‐5 by interleukin‐2‐dependent and ‐independent mechanisms in freshly isolated human T cells (2002) (69)
Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes. (2014) (69)
Effects of short-term and long-term treatment with inhaled corticosteroids on bone metabolism in patients with airways obstruction. Dutch CNSLD Study Group. (1994) (69)
miR-638 regulates gene expression networks associated with emphysematous lung destruction (2013) (68)
Eosinophilia and positive skin tests predict cardiovascular mortality in a general population sample followed for 30 years. (1999) (68)
Long-term circadian effects of salmeterol in asthmatic children treated with inhaled corticosteroids. (1995) (68)
Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12. (2002) (68)
Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control. (2008) (68)
Distribution of peak expiratory flow variability by age, gender and smoking habits in a random population sample aged 20-70 yrs. (1994) (67)
Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life (2010) (67)
Provocation with adenosine 5'-monophosphate increases sputum eosinophils. (2003) (66)
First study of infliximab treatment in patients with chronic obstructive pulmonary disease (2005) (66)
Differential expression and distribution of epithelial adhesion molecules in non-small cell lung cancer and normal bronchus (2006) (66)
Additive anti-inflammatory effect of formoterol and budesonide on human lung fibroblasts (2002) (65)
Genomewide screen for pulmonary function in 200 families ascertained for asthma. (2005) (65)
Clinical evaluation of the effect of anti-allergic mattress covers in patients with moderate to severe asthma and house dust mite allergy: a randomised double blind placebo controlled study (2002) (64)
Exploring the relevance and extent of small airways dysfunction in asthma: baseline data from the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) prospective cohort study (2019) (64)
Interferon-gamma and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts. (1999) (64)
INFLUENCE OF INHALED TERBUTALINE ON BRONCHIAL RESPONSIVENESS (1988) (64)
Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium. (2007) (63)
TGF‐β‐induced profibrotic signaling is regulated in part by the WNT receptor Frizzled‐8 (2016) (63)
Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (2014) (63)
Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1). (2010) (63)
Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients (2006) (63)
Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness (2009) (62)
Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD (2012) (62)
The 8‐year follow‐up of the PIAMA intervention study assessing the effect of mite‐impermeable mattress covers (2012) (62)
Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways. (2017) (61)
Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. (2009) (61)
Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD (2014) (61)
Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD. (2011) (60)
Exhaled nitric oxide is higher both at day and night in subjects with nocturnal asthma. (1998) (60)
Perinatal risk factors for wheezing phenotypes in the first 8 years of life (2013) (60)
Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease. (2005) (60)
Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD. (2007) (60)
Clinical control of asthma associates with measures of airway inflammation (2012) (59)
Different Modulation of Decorin Production by Lung Fibroblasts from Patients with Mild and Severe Emphysema (2005) (59)
The effects of oral slow-release terbutaline on the circadian variation in spirometry and arterial blood gas levels in patients with chronic airflow obstruction. (1985) (59)
Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. (1996) (59)
Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population (2009) (59)
Dietary factors and lung function in the general population: wine and resveratrol intake (2011) (58)
An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. (2012) (58)
Elemental Constituents of Particulate Matter and Newborn’s Size in Eight European Cohorts (2015) (58)
Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood. (2010) (58)
Sex and gender differences in lung development and their clinical significance. (2004) (58)
Pulmonary function in systemic lupus erythematosus is related to distinct clinical, serologic, and nailfold capillary patterns. (1992) (57)
Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection. (2004) (57)
The role of female sex hormones in the development and severity of allergic and non‐allergic asthma (2009) (57)
Association of season of birth with DNA methylation and allergic disease (2016) (56)
Effects of pets on asthma development up to 8 years of age: the PIAMA study (2009) (56)
Treatment of nocturnal airway obstruction improves daytime cognitive performance in asthmatics. (1997) (56)
Risk factors from childhood to adulthood for bronchial responsiveness at age 32-42 yr. (1999) (56)
Oxidant-induced corticosteroid unresponsiveness in human bronchial epithelial cells (2013) (56)
Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis (2017) (56)
Asthma: from childhood to adulthood (1996) (55)
Decorin and TGF-β1 polymorphisms and development of COPD in a general population (2006) (55)
Nuclear Receptor Nur77 Attenuates Airway Inflammation in Mice by Suppressing NF-κB Activity in Lung Epithelial Cells (2015) (55)
Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study (2017) (55)
DIFFERENT PROLIFERATIVE CAPACITY OF LUNG FIBROBLASTS OBTAINED FROM CONTROL SUBJECTS AND PATIENTS WITH EMPHYSEMA (2003) (55)
Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease (2012) (55)
Definitions of exacerbations: does it really matter in clinical trials on COPD? (2009) (54)
Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice (2007) (54)
Eosinophilia is associated with increased all-cause mortality after a follow-up of 30 years in a general population sample. (2000) (54)
Polymorphisms in SPINK5 are not associated with asthma in a Dutch population. (2005) (54)
Increased levels of (class switched) memory B cells in peripheral blood of current smokers (2009) (54)
Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD (2012) (54)
Selective acylation of primary amines in peptides and proteins. (2007) (54)
Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study (2013) (54)
Smoking and airway hyperresponsiveness especially in the presence of blood eosinophilia increase the risk to develop respiratory symptoms: a 25-year follow-up study in the general adult population. (1999) (54)
Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airways disease. Dutch CNSLD Study Group. (1993) (53)
Provocation with adenosine 5′‐monophosphate, but not methacholine, induces sputum eosinophilia (2004) (53)
Peak expiratory flow variability, bronchial responsiveness, and susceptibility to ambient air pollution in adults. (1998) (53)
Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort. (2013) (53)
Uncontrolled asthma at age 8: The importance of parental perception towards medication (2011) (53)
Assessment of ventilatory variables in survival prediction of patients with chronic airflow obstruction: the importance of reversibility. (1985) (52)
Changes in respiratory symptoms and airway hyperresponsiveness after 27 years in a population-based sample of school children. (1993) (52)
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Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD (2016) (52)
Susceptibility to air pollution in elderly males and females (2005) (51)
Superoxide dismutases, lung function and bronchial responsiveness in a general population (2009) (51)
Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination (2008) (51)
miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD (2017) (50)
Frequency of nocturnal symptoms in asthmatic children attending a hospital out-patient clinic. (1995) (50)
Occupational exposure to pesticides is associated with differential DNA methylation (2016) (50)
Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice (2001) (50)
Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report (2011) (50)
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Inflammatory cell number and mediators in bronchoalveolar lavage fluid and peripheral blood in subjects with asthma with increased nocturnal airways narrowing. (1995) (50)
Adding formoterol to budesonide in moderate asthma--health economic results from the FACET study. (2001) (49)
Early and late asthmatic reaction after allergen challenge. (1994) (49)
Genetics of onset of asthma (2013) (49)
Childhood diet and asthma and atopy at 8 years of age: the PIAMA birth cohort study (2010) (49)
Advanced glycation endproducts and their receptor in different body compartments in COPD (2016) (49)
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure☆ (2014) (49)
Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (2016) (49)
Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD (2016) (49)
Prostaglandin E2 differentially modulates IL-5 gene expression in activated human T lymphocytes depending on the costimulatory signal. (1998) (49)
A score to predict short-term risk of COPD exacerbations (SCOPEX) (2015) (49)
Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study. (1995) (48)
X‐chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts (2009) (48)
Glycogen synthase kinase‐3 (GSK‐3) regulates TGF‐β1‐induced differentiation of pulmonary fibroblasts (2013) (48)
Developmental determinants in non-communicable chronic diseases and ageing (2015) (48)
The emerging landscape of dynamic DNA methylation in early childhood (2017) (48)
Starting with a higher dose of inhaled corticosteroids in primary care asthma treatment. (1998) (48)
Comparison of guidelines and self-management plans in asthma. (1997) (48)
Relation between respiratory symptoms, pulmonary function and peak flow variability in adults. (1995) (47)
Circadian variation in airway responsiveness to methacholine, propranolol, and AMP in atopic asthmatic subjects. (1993) (47)
Budesonide and formoterol inhibit ICAM-1 and VCAM-1 expression of human lung fibroblasts. (2000) (47)
Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis (2017) (47)
Dissimilarity in methacholine and adenosine 5'-monophosphate responsiveness 3 and 24 h after allergen challenge. (1991) (47)
Shared genetic variants suggest common pathways in allergy and autoimmune diseases (2017) (47)
Antinuclear autoantibodies are more prevalent in COPD in association with low body mass index but not with smoking history (2010) (47)
Long-term multicentre trial in chronic nonspecific lung disease: methodology and baseline assessment in adult patients. Dutch CNSLD Study Group. (1992) (47)
Different Genes Interact with Particulate Matter and Tobacco Smoke Exposure in Affecting Lung Function Decline in the General Population (2012) (46)
PC(20) adenosine 5'-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine. (2001) (46)
Inhaled corticosteroids in COPD: a case in favour (2009) (46)
Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells (2007) (46)
Airway remodeling and long-term decline in lung function in asthma (2003) (46)
Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease. (2017) (46)
Genome‐wide association study on the FEV1/FVC ratio in never‐smokers identifies HHIP and FAM13A (2017) (46)
PEF variability, bronchial responsiveness and their relation to allergy markers in a random population (20-70 yr). (1996) (45)
A new perspective on optimal care for patients with COPD. (2011) (45)
Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma (2016) (45)
An evaluation of exact matching and propensity score methods as applied in a comparative effectiveness study of inhaled corticosteroids in asthma (2017) (45)
The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease. (2004) (45)
β2 adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cells (2002) (45)
Association of occupational pesticide exposure with accelerated longitudinal decline in lung function. (2014) (45)
Perinatal risk factors for bronchial hyperresponsiveness and atopy after a follow-up of 20 years. (2004) (44)
Effects of 4 months of smoking in mice with ovalbumin‐induced airway inflammation (2007) (44)
Do Differences in Childhood Diet Explain the Reduced Overweight Risk in Breastfed Children? (2008) (44)
GSTCD and INTS12 Regulation and Expression in the Human Lung (2013) (44)
The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study (2005) (44)
Primary pulmonary hypertension in a patient with systemic lupus erythematosus: partial improvement with cyclophosphamide. (1993) (43)
Effects of small airway dysfunction on the clinical expression of asthma: a focus on asthma symptoms and bronchial hyper‐responsiveness (2014) (43)
Safety of sputum induction during exacerbations of COPD. (2007) (43)
Evidence for multiple genetic susceptibility loci for asthma. (1997) (43)
Are inhaled glucocorticosteroids effective in chronic obstructive pulmonary disease? (1999) (43)
Feasibility and effects of a home-care rehabilitation program in patients with chronic obstructive pulmonary disease. (1996) (43)
Childhood wheezing phenotypes and FeNO in atopic children at age 8 (2012) (42)
Effect of an inhaled adenosine A2A agonist on the allergen‐induced late asthmatic response (2007) (42)
The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth (2017) (42)
Predictors of COPD symptoms: does the sex of the patient matter? (2006) (42)
Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma‐like symptoms (2012) (42)
Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome? (2016) (42)
Sleep in children with asthma: results of the PIAMA study (2012) (41)
Association of mast cells with lung function in chronic obstructive pulmonary disease (2008) (41)
Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD. (2013) (41)
Macrophages in lung tissue from patients with pulmonary emphysema express both inducible and endothelial nitric oxide synthase. (1998) (41)
Differential switching to IgG and IgA in active smoking COPD patients and healthy controls (2012) (41)
Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts (2011) (41)
E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids (2011) (41)
Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels. (2015) (41)
Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD: from specific disease phenotyping towards novel therapy. Protocol of a cross-sectional study (2013) (41)
Screen time, adiposity and cardiometabolic markers: mediation by physical activity, not snacking, among 11-year-old children (2014) (41)
FVC to slow inspiratory vital capacity ratio: a potential marker for small airways obstruction. (2007) (40)
Chemical labeling and enrichment of nitrotyrosine-containing peptides. (2010) (40)
Air Pollution and Lung Function in Dutch Children: A Comparison of Exposure Estimates and Associations Based on Land Use Regression and Dispersion Exposure Modeling Approaches (2015) (40)
Small-particle Inhaled Corticosteroid as First-line or Step-up Controller Therapy in Childhood Asthma. (2015) (40)
Individualized prediction of lung-function decline in chronic obstructive pulmonary disease (2016) (40)
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease (2012) (40)
The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty ‐ a study by MeDALL (2017) (40)
Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: results from the ESCAPE and TRANSPHORM projects. (2014) (40)
Importance of total serum IgE for improvement in airways hyperresponsiveness with inhaled corticosteroids in asthma and chronic obstructive pulmonary disease. The Dutch CNSLD Study Group. (1995) (40)
Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort. (2009) (40)
Polarized Th1 and Th2 cells are less responsive to negative feedback by receptors coupled to the AC/cAMP system compared to freshly isolated T cells (2003) (39)
Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthma. (2005) (39)
The yin and the yang of immunosuppression with inhaled corticosteroids (2013) (39)
Circadian change in bronchial responsiveness and airflow obstruction in asthmatic children. (1989) (39)
Risk factors for accelerated decline among patients with chronic obstructive pulmonary disease. (1996) (39)
Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study (2015) (39)
Higher patient perceived side effects related to higher daily doses of inhaled corticosteroids in the community: a cross-sectional analysis. (2006) (39)
Difference in the Breast Milk Proteome between Allergic and Non-Allergic Mothers (2015) (38)
Intestinal lactobacilli and the DC-SIGN gene for their recognition by dendritic cells play a role in the aetiology of allergic manifestations. (2010) (38)
microRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD (2018) (38)
The child is father of the man? (2014) (38)
Lymphocyte and macrophage activation in bronchoalveolar lavage fluid in nocturnal asthma. (1995) (38)
Sex differences in asthma during the first 8 years of life: the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study. (2011) (38)
Effects of cigarette smoke extract on human airway smooth muscle cells in COPD (2014) (38)
Anti-Inflammatory Effects of Combined Budesonide/Formoterol in COPD Exacerbations (2008) (38)
Longitudinal profile of bronchoalveolar lavage cell characteristics in patients with a good outcome after lung transplantation. (2002) (38)
Beneficial effects of treatment with anti-IgE antibodies (Omalizumab) in a patient with severe asthma and negative skin-prick test results. (2011) (38)
I have taken my umbrella, so of course it does not rain (2011) (37)
Identification of Polymorphisms in the Human Glucocorticoid Receptor Gene (NR3C1) in a Multi-racial Asthma Case and Control Screening Panel (2004) (37)
Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease (2012) (37)
Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS. (2008) (37)
Genetics of allergic disease. (2000) (37)
Lung tissue gene-expression signature for the ageing lung in COPD (2017) (37)
Maternal smoking during pregnancy decreases Wnt signalling in neonatal mice (2010) (37)
Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels (2014) (37)
Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics (2013) (37)
Partial inhibition of the early and late asthmatic response by a single dose of salmeterol. (1994) (37)
Exogenous stimuli and circadian peak expiratory flow variation in allergic asthmatic children. (1996) (37)
Phenotype definition, age, and gender in the genetics of asthma and atopy. (2005) (36)
SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells (2018) (36)
Advanced glycation end products in the skin are enhanced in COPD. (2014) (36)
The genetics of atopy and airway hyperresponsiveness. (2000) (35)
Characterization of protocadherin‐1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation (2012) (35)
Successful Smoking Cessation in COPD: Association with Comorbidities and Mortality (2012) (35)
Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease (2012) (35)
Increased peak expiratory flow variation in asthma: severe persistent increase but not nocturnal worsening of airway inflammation. (1998) (35)
High cessation rates of cigarette smoking in subjects with and without COPD. (2005) (35)
Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts (2017) (34)
Relapse in FEV1 Decline After Steroid Withdrawal in COPD. (2015) (34)
Assessment of airway inflammation: an overview. (1998) (34)
Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma (2010) (34)
Host-microbial interactions in childhood atopy: toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli. (2010) (34)
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (2014) (34)
TRPA1 gene polymorphisms and childhood asthma (2016) (34)
Chronic obstructive pulmonary disease in men and women: myths and reality. (2009) (33)
ADAM33 gene: confirming a gene without linkage (2004) (33)
HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. (2010) (33)
Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene (2013) (33)
Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. (2010) (33)
Separate and combined effects of corticosteroids and bronchodilators on airflow obstruction and airway hyperresponsiveness in asthma. (1992) (33)
Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers: a cross sectional study (2013) (32)
Repeated sputum inductions induce a transient neutrophilic and eosinophilic response. (2006) (32)
High ICAM-1 gene expression in pulmonary fibroblasts of COPD patients: a reflection of an enhanced immunological function (2006) (32)
Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms. (2008) (32)
Relief of dyspnoea by beta2-agonists after methacholine-induced bronchoconstriction. (2004) (32)
Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate (2009) (32)
Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids (2016) (32)
Effects of short term and long term treatment with inhaled corticosteroids on bone metabolism in patients with airways obstruction (31)
Effects of budesonide and bambuterol on circadian variation of airway responsiveness and nocturnal symptoms of asthma. (1992) (31)
A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. (2011) (31)
Budesonide and fluticasone propionate differentially affect the airway epithelial barrier (2016) (31)
A self-rating scale for patient-perceived side effects of inhaled corticosteroids (2006) (31)
Reliever salbutamol use as a measure of exacerbation risk in chronic obstructive pulmonary disease (2015) (31)
Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD (2014) (31)
Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction (2014) (31)
Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD (2014) (31)
Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children (2009) (31)
Risk of pneumonia in obstructive lung disease: A real-life study comparing extra-fine and fine-particle inhaled corticosteroids (2017) (31)
Effects of ageing and smoking on pulmonary computed tomography scans using parametric response mapping (2015) (31)
Bronchoalveolar lavage cell analysis and lung function impairment in patients with systemic lupus erythematosus (SLE) (1993) (30)
Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells (2008) (30)
Adverse effects of eosinophilia and smoking on the natural history of newly diagnosed chronic bronchitis. (1995) (30)
Integrative Genomics of Emphysema‐Associated Genes Reveals Potential Disease Biomarkers (2017) (30)
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Susceptibility to COPD: Differential Proteomic Profiling after Acute Smoking (2014) (30)
Endotoxin exposure, CD14 and wheeze among farmers: a gene–environment interaction (2011) (29)
Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease. (2014) (29)
Differences between males and females in the natural history of asthma and COPD (2003) (29)
Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression (2017) (29)
Mast cell numbers in airway smooth muscle and PC20AMP in asthma and COPD. (2007) (29)
Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies. (2017) (29)
Airway responsiveness to adenosine 5'-monophosphate in smokers and nonsmokers with atopic asthma. (1993) (29)
Genetics of asthma susceptibility and severity. (2012) (29)
Techniques in human airway inflammation: quantity and morphology of bronchial biopsy specimens taken by forceps of three sizes. (1998) (29)
Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in the Netherlands: the PIAMA birth cohort study (2009) (29)
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020) (28)
Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study (2011) (28)
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Persistence and new onset of asthma and chronic bronchitis evaluated longitudinally in a community population sample of adults. (1995) (27)
Airway inflammation contributes to health status in COPD: a cross-sectional study (2006) (27)
Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia (2011) (27)
A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis (2016) (26)
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Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids. (2014) (26)
Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy‐based study (2012) (26)
Blood Pressure in 12-Year–Old Children Is Associated With Fatty Acid Composition of Human Milk: The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort (2012) (26)
Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study (2016) (26)
CT-Based Local Distribution Metric Improves Characterization of COPD (2017) (26)
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SERPINE1 -675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid response (2011) (25)
Sexual maturation protects against development of lung inflammation through estrogen. (2016) (25)
Resistance of activated human Th2 cells to NO-induced apoptosis is mediated by gamma-glutamyltranspeptidase. (2001) (25)
Localization and Enhanced mRNA Expression of the Orphan Chemokine Receptor L-CCR in the Lung in a Murine Model of Ovalbumin-induced Airway Inflammation (2004) (25)
Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses. (2015) (25)
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Precapillary Pulmonary Hypertension Dramatically Improved With High Doses of Corticosteroids During Systemic Lupus Erythematosus - Reply (1994) (25)
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Fluticasone uptake across Calu‐3 cells is mediated by salmeterol when deposited as a combination powder inhaler (2013) (24)
Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD (2018) (24)
Microarray amplification bias: loss of 30% differentially expressed genes due to long probe – poly(A)-tail distances (2007) (24)
Genetic variants in the serotonin transporter influence the efficacy of bupropion and nortriptyline in smoking cessation. (2012) (24)
Blood eosinophilia and the number of exacerbations in COPD patients (2014) (23)
Impact of acute exposure to cigarette smoke on airway gene expression. (2018) (23)
ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts (2009) (23)
Plethysmographic parameters in the assessment of reversibility of airways obstruction in patients with clinical emphysema. (1993) (23)
Toll-Like Receptor 4 Polymorphism Associated with the Response to Whole-Cell Pertussis Vaccination in Children from the KOALA Study (2007) (23)
Genetic and epigenetic regulation of YKL‐40 in childhood (2017) (23)
Physiology of the small airways: A gender difference? (2008) (23)
Unmet needs for the assessment of small airways dysfunction in asthma: introduction to the ATLANTIS study (2015) (23)
Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD (2010) (23)
Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma (2018) (23)
Health-related quality of life in asthma studies. Can we combine data from different countries? (2003) (23)
Computational analysis of multimorbidity between asthma, eczema and rhinitis (2017) (23)
Association between peripheral airway function and neutrophilic inflammation in asthma (2015) (22)
Exposure to TARC alters beta2-adrenergic receptor signaling in human peripheral blood T lymphocytes. (2005) (22)
Lung function decline in male heavy smokers relates to baseline airflow obstruction severity. (2012) (22)
Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. (2016) (22)
Limited agreement between current and long‐term asthma control in children: the PACMAN cohort study (2011) (22)
NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. (2012) (22)
Occupational exposure to vapors, gases, dusts, and fumes is associated with small airways obstruction. (2014) (22)
Cost-effectiveness of initiating extrafine- or standard size-particle inhaled corticosteroid for asthma in two health-care systems: a retrospective matched cohort study (2014) (22)
Genetics of asthma: where are we and where do we go? (2009) (22)
Defining asthma in genetic studies. (1999) (22)
Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control. (2011) (22)
Role of Adenosine Receptors in the Treatment of Asthma and Chronic Obstructive Pulmonary Disease (2007) (22)
Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice (2010) (22)
House dust mite exposure in asthmatic and healthy children: the difference is carpeting (1995) (21)
Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo (2015) (21)
Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis. (2015) (21)
Influence of in vivo prednisolone on increased in vitro O2- generation by neutrophils in emphysema. (1993) (21)
Genetic susceptibility to asthma in a changing environment. (1997) (21)
Effects of budesonide and formoterol on eosinophil activation induced by human lung fibroblasts. (2000) (21)
Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD (2014) (21)
Increased Dose of Inhaled Corticosteroid versus Add-On Long-acting β-Agonist for Step-Up Therapy in Asthma. (2015) (21)
Activation of the cAMP-dependent signaling pathway downregulates the expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor in activated human T lymphocytes. (1996) (21)
Air pollution exposure is associated with restrictive ventilatory patterns (2016) (21)
Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. (2014) (21)
Hyperresponsiveness as a determinant of the outcome in chronic obstructive pulmonary disease. (1991) (20)
ST13 polymorphisms and their effect on exacerbations in steroid‐treated asthmatic children and young adults (2015) (20)
The genetics of CD14 in allergic disease (2003) (20)
All men are created equal?: new leads in explaining sex differences in adult asthma. (2009) (20)
Breathlessness in elderly individuals is related to low lung function and reversibility of airway obstruction. (1998) (20)
Novel genes and insights in complete asthma remission: A genome‐wide association study on clinical and complete asthma remission (2018) (20)
Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma (2013) (20)
Nicotinic Acetylcholine Receptor Variants Are Related to Smoking Habits, but Not Directly to COPD (2012) (20)
Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD (2020) (20)
COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression (2017) (20)
Genetic variation in uncontrolled childhood asthma despite ICS treatment (2015) (20)
Toll-like receptors and microbial exposure: gene–gene and gene–environment interaction in the development of atopy (2011) (20)
Airway wall thickness on HRCT scans decreases with age and increases with smoking (2017) (20)
Inflammation in nocturnal asthma? (1994) (19)
Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial (2015) (19)
Childhood factors associated with complete and clinical asthma remission at 25 and 49 years (2017) (19)
Variation in European antibiotic use (2001) (19)
Assessment of airway inflammation (1998) (19)
Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium (2017) (19)
Basal or stress-induced cortisol and asthma development: the TRAILS study (2012) (19)
Repeatability of bronchial hyperresponsiveness to adenosine-5′-monophosphate (AMP) by a short dosimeter protocol (2001) (19)
Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma (2016) (19)
Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma. (2012) (19)
High agreement between parental reported inhaled corticosteroid use and pharmacy prescription data (2010) (19)
Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH (2014) (19)
Mycophenolate mofetil and bronchiectasis in kidney transplant patients: a possible relationship. (2006) (19)
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD (2011) (19)
The Effect of Reduction of Maintenance Treatment on Circadian Variation in Peak Expiratory Flow Rate Values in Asthmatic Children (1988) (19)
Airway responsiveness in childhood as a predictor of the outcome of asthma in adulthood. (1991) (18)
VEGFA variants are associated with pre‐school lung function, but not neonatal lung function (2013) (18)
Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands (2016) (18)
L-Arginine is not the limiting factor for nitric oxide synthesis by human alveolar macrophages in vitro. (2001) (18)
GST-omega genes interact with environmental tobacco smoke on adult level of lung function (2013) (18)
Nedocromil sodium versus albuterol in the management of allergic asthma. (1994) (18)
Eosinophilic inflammation in subjects with mild-to-moderate asthma with and without obesity: disparity between sputum and biopsies. (2014) (18)
Genetics of allergy and bronchial hyperresponsiveness (1999) (17)
BRONCHODILATOR THERAPY WITH OR WITHOUT INHALED CORTICOSTEROID-THERAPY FOR OBSTRUCTIVE AIRWAYS DISEASE - REPLY (1993) (17)
Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics (2018) (17)
Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages. (2016) (17)
Risk of overtreatment with current peak flow criteria in self-management plans. Dutch CNSLD Study Group. Chronic Non-Specific Lung Disease. (1998) (17)
Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells. (2018) (17)
Operative definition of active and healthy ageing (AHA): Meeting report. Montpellier October 20-21, 2014 (2015) (17)
Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering. (2009) (17)
Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure (2017) (17)
Genetic and environmental influences on objective intermediate asthma phenotypes in Dutch twins (2010) (17)
Heme oxygenase 1 variations and lung function decline in smokers: proof of replication (2008) (17)
Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients (2017) (17)
Sensitivity of IL‐5 production to the cAMP‐dependent pathway in human T cells is reduced by exogenous IL‐2 in a phosphoinositide 3‐kinase‐dependent way (2003) (16)
Waist circumference, BMI, and lung function in 8‐year‐old children: The PIAMA birth cohort study (2013) (16)
LifeLines: a three-generation population-based study (2008) (16)
Dutch approach to the study of the genetics of asthma (1995) (16)
Lung expression quantitative trait loci data set identifies important functional polymorphisms in the asthma-associated IL1RL1 region. (2014) (16)
Initial improvements in lung function and bronchial hyperresponsiveness are maintained during 5 years of treatment with inhaled beclomethasone dipropionate and terbutaline. (2002) (16)
Interstitial lung disease and myositis in a patient with simultaneously occurring sarcoidosis and scleroderma. (1993) (16)
Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic airflow obstruction (2005) (16)
Protocadherin‐1 polymorphisms are associated with eczema in two Dutch birth cohorts (2012) (16)
ITGB5 and AGFG1 variants are associated with severity of airway responsiveness (2013) (16)
Steroid Resistance in COPD? Overlap and Differential Anti-Inflammatory Effects in Smokers and Ex-Smokers (2014) (16)
Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants: KOALA Birth Cohort Study (2013) (16)
Proteomics of epithelial lining fluid obtained by bronchoscopic microprobe sampling. (2011) (16)
Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study (2013) (16)
Inhaled therapy in COPD: what are the benefits? (1991) (16)
Allergen inhalation decreases adenosine receptor expression in sputum and blood of asthma patients (2008) (16)
OBJECTIVE AND SUBJECTIVE PERFORMANCE INDICATORS IN COPD (1989) (16)
Changes in CD11b and L-selectin expression on eosinophils are mediated by human lung fibroblasts in vitro. (1998) (16)
Objective allergy markers and risk of cancer mortality and hospitalization in a large population-based cohort (2014) (15)
Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE (2009) (15)
Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts. (2014) (15)
Effect of oral slow-release terbutaline on early morning dyspnoea (2004) (15)
Clinical evaluation of lymphocyte sub-populations and oxygen radical production in sarcoidosis and idiopathic pulmonary fibrosis. (1994) (15)
Lack of correlation between bronchoconstrictor response and bronchodilator response in a population-based study. (1997) (15)
Recognition of Asthma in Adolescents and Young Adults: Which Objective Measure is Best? (2005) (15)
Latrophilin receptors: novel bronchodilator targets in asthma (2016) (15)
RETRACTED ARTICLE: Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all? (2008) (15)
Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness (2002) (14)
Submucosa 1.0 x 0.1 mm in size is sufficient to count inflammatory cell numbers in human airway biopsy specimens. (1998) (14)
CD14 polymorphisms in mother and infant, soluble CD14 in breast milk and atopy development in the infant (KOALA Study) (2009) (14)
Obtaining optimal control in mild asthma: theory and practice. (2005) (14)
PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma (2017) (14)
Localization and Quantification of Regional and Segmental Air Trapping in Asthma (2008) (13)
Seasonal variations in house dust mite influence the circadian peak expiratory flow amplitude. (1996) (13)
New immunosuppressive drugs and lung transplantation: last or least? (1999) (13)
Changes in peak expiratory flow indices as a proxy for changes in bronchial hyperresponsiveness. Dutch Chronic Non-Specific Lung Disease study group. (2000) (13)
Asthma Therapy During the First 8 Years of Life: A PIAMA Cohort Study (2010) (13)
Gender and COPD: Why it matters. (2007) (13)
Susceptibility loci regulating total serum IgE levels, bronchial hyperresponsiveness, and clinical asthma map to chromosome 5q. (1997) (13)
Gastric asthma: a pathophysiological entity? (1998) (13)
Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis (2011) (13)
Real-Life Outcomes for Patients with Asthma Prescribed Spacers for Use with Either Extrafine- or Fine-Particle Inhaled Corticosteroids. (2017) (13)
The different faces of the asthma−COPD overlap syndrome (2015) (13)
Effect of Ciclesonide Treatment on Allergen-Induced Changes in T Cell Regulation in Asthma (2007) (13)
An economic evaluation of budesonide/formoterol for maintenance and reliever treatment in asthma in general practice (2009) (12)
Childhood overweight and asthma symptoms, the role of pro‐inflammatory proteins (2012) (12)
Overweight in Infancy: Which Pre- and Perinatal Factors Determine Overweight Persistence or Reduction A Birth Cohort Followed for 11 Years (2014) (12)
Effects of nedocromil sodium in the treatment of non-allergic subjects with chronic obstructive pulmonary disease. (1994) (12)
IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids (2019) (12)
Formoterol used as needed improves health-related quality of life in asthmatic patients uncontrolled with inhaled corticosteroids. (2003) (12)
Genome screen for susceptibility loci for bronchial hyperresponsiveness in a genetically homogeneous Dutch population. (1999) (12)
Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids (2016) (12)
Early response to inhaled bronchodilators and corticosteroids as a predictor of 12-month treatment responder status and COPD exacerbations (2016) (12)
Gene-gene interaction in asthma (2002) (12)
Overweight patterns throughout childhood and cardiometabolic markers in early adolescence (2016) (12)
ADAM33 Gene Polymorphisms and Mortality. A Prospective Cohort Study (2013) (12)
Polymorphisms in the Mannan-Binding Lectin Gene Are Not Associated with Questionnaire-Reported Respiratory Tract Infections in Children (2008) (11)
Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD. (2012) (11)
Can AMP induce sputum eosinophils, even in subjects with complete asthma remission? (2010) (11)
Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study (2015) (11)
Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper‐responsiveness (2015) (11)
Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice. (2008) (11)
Adenosine receptors in COPD and asymptomatic smokers: effects of smoking cessation (2009) (11)
Genetic risk scores do not improve asthma prediction in childhood. (2019) (11)
Development of a tool to recognize small airways dysfunction in asthma (SADT) (2014) (11)
Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies. (2012) (11)
Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1 (2020) (11)
Add-on LABA in a separate inhaler as asthma step-up therapy versus increased dose of ICS or ICS/LABA combination inhaler (2016) (11)
Interaction between nitric oxide and subsets of human T lymphocytes with differences in glutathione metabolism (2002) (11)
Nocturnal asthma: not a separate disease entity. (1994) (11)
Gas cooking, respiratory and allergic outcomes in the PIAMA birth cohort study (2012) (10)
Bronchial hyper‐responsiveness to hypertonic saline and blood eosinophilic markers in 8–13‐year‐old schoolchildren (2004) (10)
Where Are We and Where Do We Go (2009) (10)
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche DTU Orbit (05/11/2017) (2014) (10)
Pubertal Timing and Cardiometabolic Markers at Age 16 Years. (2017) (10)
Susceptibility genes for lung diseases in the major histocompatibility complex revealed by lung expression quantitative trait loci analysis (2016) (10)
Nocturnal dry cough in the first 7 years of life is associated with asthma at school age (2015) (10)
Diagnosis and management of asthma, COPD and asthma‐COPD overlap among primary care physicians and respiratory/allergy specialists: A global survey (2019) (10)
Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17+ Cells in Asthmatic Airways (2016) (10)
Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD (2016) (10)
Exhaled nitric oxide concentration is influenced by alcohol containing disinfectants. (1996) (10)
Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers: Eur Respir J 2005;26:835–845 (2006) (10)
The reproducibility and agreement of three indices of airway responsiveness to histamine in asthmatic children (1989) (10)
Mini-Wright peak flow meters are reliable after 5 years use. Dutch CNSLD Study Group. (1997) (10)
Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1. (2008) (9)
Variants of the FADS 1 FADS 2 Gene Cluster , Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life (2010) (9)
Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease (2016) (9)
Patterns of asthma medication use: early asthma therapy initiation and asthma outcomes at age 8 † (2010) (9)
In vitro release of neutrophil elastase, myeloperoxidase and beta-glucuronidase in patients with emphysema and healthy subjects. (1991) (9)
Airway cellular response to two different immunosuppressive regimens in lung transplant recipients (2005) (9)
Association of ADAM33 with asthma and associated phenotypes in ethnically diverse populations. (2002) (9)
Effect of Polymorphisms in the Beta2-Adrenergic Receptor Gene (ADRB2) on Response to Long-Acting Beta2-Agonist (LABA) Therapy (2007) (9)
Development of a brief questionnaire (ICQ‐S) to monitor inhaled corticosteroid side‐effects in clinical practice (2014) (9)
University of Groningen Activation of WNT/beta-Catenin Signaling in Pulmonary Fibroblasts by TGF-beta(1) Is Increased in Chronic Obstructive Pulmonary Disease Baarsma, Hoeke (2011) (9)
Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD (2019) (9)
No effects of EPHX1 polymorphisms on the level or change of FEV1 in the general population (2008) (9)
FROM GENETICS TO QUALITY OF LIFE (1996) (9)
Lower Corticosteroid Skin Blanching Response Is Associated with Severe COPD (2014) (9)
Using COPD multidimensional indices in routine clinical practice: DOSE meets all criteria. (2012) (9)
Prognosis in severe chronic obstructive pulmonary disease with regard to the electrocardiogram. (1983) (9)
Extrafine compared to non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. (2017) (9)
Variants in the 15q24/25 Locus Associate with Lung Function Decline in Active Smokers (2013) (8)
A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants (2018) (8)
Difference between patient-reported side effects of ciclesonide versus fluticasone propionate. (2010) (8)
The effect of COPD severity and study duration on exacerbation outcome in randomized controlled trials (2017) (8)
Airway and peripheral uPAR is elevated in asthma, and identifies a severe, non-atopic subset of patients (2016) (8)
Development of a questionnaire for the assessment of bronchial hyperresponsiveness. (2009) (8)
Factor analysis in predominantly severe COPD: identification of disease heterogeneity by easily measurable characteristics. (2013) (8)
Long-term intervention in chronic obstructive pulmonary disease (2004) (8)
Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma (2016) (8)
The candidate gene approach in asthma: what happens with the neighbours? (2010) (8)
Role of proteoglycans in development and pathogenesis of emphysema. : Proteoglycans in Lung Disease (2002) (8)
Airway epithelial changes in smoking but not in ex-smoking asthmatics (2009) (7)
Systematic review protocol to define classical IgE-associated diseases from birth to adolescence: the MeDALL study (2012) (7)
Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids (2017) (7)
Change in HbA1c Levels between the Age of 8 Years and the Age of 12 Years in Dutch Children without Diabetes: The PIAMA Birth Cohort Study (2015) (7)
The relationship between reversibility and hyperreactivity. (1988) (7)
Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease (2017) (7)
Fibulin-5 as a potential therapeutic target in COPD (2016) (7)
Resistance of activated human Th 2 cells to NO-induced apoptosis is mediated by γ-glutamyltranspeptidase (2001) (7)
Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children (2019) (7)
Fraction of exhaled nitric oxide values in childhood are associated with 17 q 11 . 2q 12 and 17 q 12-q 21 variants (7)
RETRACTED ARTICLE: Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all? (2008) (7)
Asthma and COPD: Common Genes, Common Environments? (2011) (7)
Cloning, pharmacological characterization, and polymorphism screening of the guinea pig beta(2)-adrenoceptor. (2002) (7)
Adrenergic response in children with asthma on exogenous stimuli (1992) (7)
Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma (2012) (7)
Corticosteroids and IgE (1996) (6)
The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction. (2016) (6)
Conventional RIA underestimates cortisol suppression in the presence of prednisolone. (2002) (6)
Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease: Thorax 2005;60:992–7 (2006) (6)
Clinical expression of airway hyperreactivity in adults (1989) (6)
Targeting the small airways with dry powder adenosine: a challenging concept (2017) (6)
Pulmonary function in patients presenting with Raynaud's phenomenon without an underlying connective tissue disease. A prospective, longitudinal study. (1989) (6)
ADAM 33 Gene Polymorphisms and Mortality . A Prospective Cohort Study (2013) (6)
Authors’ response (2012) (6)
Comparative study of the bronchodilating effects of (-)- and (+)-oxyphenonium bromide. (1988) (6)
The beta-adrenergic system of non-allergic patients with chronic airflow obstruction and early morning dyspnoea. (1987) (6)
Disease associated time consumption in early rheumatoid arthritis. (2000) (6)
Effect of high-dose omeprazole on airway hyperresponsiveness and pulmonary function in patients with obstructive lung disease (1995) (6)
Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma (2018) (6)
Does inhaled budesonide protect against cardio-ischaemic events in mild-moderate COPD - a post-hoc evaluation of the EUROSCOP study (2005) (6)
Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease (2011) (5)
Crosstalk between epithelium and fibroblasts; implications for COPD (2014) (5)
Genetics of glucocorticoids in asthma. (2011) (5)
A role for WNT-5B in airway remodeling in COPD by activation of TGF-β/Smad3 signaling? (2013) (5)
Confounding effect of atopy on functional effects of the CD14/-159 promoter polymorphism. (2006) (5)
Old dilemma: asthma with irreversible airway obstruction or COPD (2015) (5)
Quality-of-life in a long-term multicentre trial in chronic nonspecific lung disease: assessment at baseline (2012) (5)
Hypothesis-driven Research On Genomic Data Derived From A Large Scale Lung EQTL Mapping Study (2010) (5)
The Dutch National Program for Respiratory Research. (2016) (5)
Nitrogen Dioxide Exposure Attenuates Cigarette Smoke-Induced Cytokine Production in Mice (2008) (5)
Genome-wide association analysis identi fi es three new susceptibility loci for childhood body mass index (2016) (5)
Purification of decorin core protein from human lung tissue. (2005) (5)
Genetic evaluation of the effect of GLCCI1 rs37973 on corticosteroid response in chronic obstructive pulmonary disease (2017) (5)
Formoterol used on demand improves quality of life in patients with asthma (1999) (5)
The link between asthma and COPD - Foreword (1999) (5)
Receptor for advanced glycation end products and soluble receptor for advanced glycation end products: a balancing act in chronic obstructive pulmonary disease? (2013) (5)
Heme oxygenase-1 expression in alveolar macrophages is elevated in patients with bronchiolitis obliterans syndrome after lung transplantation. (2004) (5)
Techniques in human airway inflammation: differences in plastic-embedded and snap-frozen sections for CD3, CD4, and CD8 immunostaining of bronchial biopsy specimens. (1997) (5)
Genetics of asthma and chronic obstructive pulmonary disease (2006) (5)
Confirmation of GPRA: a putative drug target for asthma. (2005) (5)
There is no activation of O2- production by alveolar macrophages and neutrophil polymorphonuclear leukocytes in rat lung transplants during the reimplantation response and acute rejection. (1992) (5)
Parental Eczema Increases the Risk of Double-Blind, Placebo-Controlled Reactions to Milk but Not to Egg, Peanut or Hazelnut (2011) (4)
Changes in peak expiratory flow in healthy subjects and in patients with obstructive lung disease. (1997) (4)
Picumeterol: dissociation of improvement in lung function and reduction of airways hyperresponsiveness in asthmatics. (2003) (4)
The role of stress in the etiology of asthma: a multidisciplinary approach (2008) (4)
MBL2 and fever during neutropenia in children with acute lymphoblastic leukaemia (2012) (4)
NOS1: a susceptibility gene for reduced level of FEV1 in the setting of pesticide exposure. (2014) (4)
Effect of ciclesonide 40 μg and 80 μg on early and late asthmatic reaction, and sputum eosinophils after allergen challenge in patients with mild asthma (2005) (4)
Genetic variants of inducible costimulator are associated with allergic asthma susceptibility. (2015) (4)
Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (2017) (4)
Long term e V ects of inhaled corticosteroids in chronic obstructive pulmonary disease : a meta-analysis (1998) (4)
Erratum: Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. (2010) (4)
Effects of corticosteroids in "chronic bronchitis" and "chronic obstructive airway disease". (1990) (4)
Impact of Statins on Gene Expression in Human Lung Tissues (2015) (4)
Nasal gene expression changes with inhaled corticosteroid treatment in asthma (2020) (4)
The significance of airway responsiveness in the onset and evolution of chronic obstructive pulmonary disease (1997) (4)
Budesonide and formoterol exert an additive effect on the inhibition of ICAM-1 and VCAM-1 upregulation and GM-CSF production of human lung fibroblasts (1999) (4)
No associations of the mineralocorticoid and glucocorticoid receptor genes with asthma (2012) (4)
Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression (2019) (4)
The Link Between Asthma and COPD. Foreword, summary and conclusions. (1999) (4)
Reticular basement membrane in asthma and COPD (2009) (4)
Bronchoalveolar lavage in a patient with recurrence of sarcoidosis after lung transplantation. (2004) (4)
4th Pediatric Allergy and Asthma Meeting (PAAM) (2016) (4)
Discrepancies in release of elastase from human peripheral polymorphonuclear leukocytes. (1986) (3)
Abstracts of papers and posters (2005) (3)
HMOX1 and GST variants modify attenuation of FEF25–75% decline due to PM10 reduction (2009) (3)
Effects of transdermal scopolamine on pulmonary function, symptoms and bronchial hyperresponsiveness to methacholine (1997) (3)
Late Breaking Abstract - Small Airways Dysfunction (SAD) correlates with relevant asthma outcomes: longitudinal results from the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study (2020) (3)
REVERSIBILITY OF AIRFLOW OBSTRUCTION (1988) (3)
Corticosteroids and IgE. Dutch CNSLD Study Group. (1996) (3)
Of fl ies , mice and men : a systematic approach to understanding the early life origins of chronic lung disease (2013) (3)
Effect of beta-adrenergic stimulation on the circulatory lymphocyte count: studies in normals and in patients with chronic airflow obstruction. (1985) (3)
Pathological Changes in the Airways of Smoking Asthma Patients (2009) (3)
QUALITY-OF-LIFE OF PATIENTS WITH COPD IMPROVES AFTER REHABILITATION AT HOME (1993) (3)
Chronic Obstructive Pulmonary Disease in Men and Women (2012) (3)
Chapter 8 Association of a promoter polymorphism of the CD 14 gene and atopy (2017) (3)
Effects of propranolol inhalation on the diurnal increase in FEV1 and on propranolol airways responsiveness in atopic subjects with asthma. (1995) (3)
Expression of vascular remodeling markers in relation to bradykinin receptors in asthma and COPD (2013) (3)
How can we measure COPD symptom control? The development of a COPD symptom control questionnaire (1999) (3)
The role of the frizzled-8 receptor in COPD with chronic mucus hypersecretion (2013) (3)
Analysis of the defensin gene family for DNA sequence variants. (2002) (3)
Inhibition of peroxynitrite formation by apocynin in a murine macrophage cell-line (1998) (3)
Effect Of Long Term Corticosteroid Treatment On Microrna And Gene Expression Profiles In Chronic Obstructive Pulmonary Disease (2015) (3)
SIRT 1 / FoxO 3 axis alteration leads to aberrant immune responses in bronchial epithelial cells (2018) (3)
Long term eVects of inhaled corticosteroids in chronic obstructive pulmonary disease: a (1999) (3)
Inflammatory phenotypes underlying uncontrolled childhood asthma despite inhaled corticosteroid treatment: rationale and design of the PACMAN2 study (2013) (3)
Increased risk of asthma in overweight children born large for gestational age (2014) (3)
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Exacerbations of asthma : a descriptive study of 425 exacerbations (2000) (2)
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Genome-wide association analysis identifies six new loci associated with forced vital capacity | NOVA. The University of Newcastle's Digital Repository (2014) (0)
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University of Groningen Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination Kimman, (2008) (0)
LSC 2013 abstract - Expression of vascular remodeling markers in relation to bradykinin receptors in asthma and COPD (2013) (0)
MiR-638 Regulates Gene Expression Changes In Human Lung Fibroblasts (2012) (0)
The Effects Of Smoking On Corticosteroid-Induced Changes In Clinical And Inflammatory Variables In Asthma (2011) (0)
MATERNAL SMOKING DURING PREGNANCY INDUCES AIRWAY REMODELING IN MICE OFFSPRING RUNNING TITLE: MATERNAL SMOKING REMODELS OFFSPRING AIRWAYS (2008) (0)
Adenosine monophosphate challenge and monitoring of airway response to antiinflammatory therapy (2002) (0)
Cigarette smoke-induced emphysema: A role for the B Cell?: Am J Respir Crit Care Med 2006; published online ahead of print on 6 January 2006 as doi:10.1164/rccm.200504-594OC (2006) (0)
Alteration In Decorin And Versican In The Lung Extra-Cellular Matrix In Centrilobular Emphysema (2012) (0)
Farm Dust Downregulates Th2-Driven Allergic Airway Inflammation In Mice; A Role For Epithelial TLR Expression And Chemokine Production (2011) (0)
Change in overweight status during childhood and asthma at 8 years of age (2008) (0)
Non-Corticosteroid Anti-Inflammatory Drugs in Asthma (1997) (0)
A novel proteogenomics approach identifying key proteins in severe COPD (2017) (0)
THE EFFECTS OF NEDOCROMIL SODIUM COMPARED WITH ALBUTEROL THERAPY ON PULMONARY-FUNCTION, AIRWAY RESPONSIVENESS AND SYMPTOM SCORES IN ALLERGIC PATIENTS WITH MILD ASTHMA (1993) (0)
TRAFFIC-RELATED AIR POLLUTION, ASTHMA AND HAY FEVER AT THE AGE OF 11 (2011) (0)
Small airways dysfunction: is there any involvement in patients with atopy? - Authors' reply. (2019) (0)
Differential effects of budesonide and fluticasone propionate on bronchial epithelial barrier function (2014) (0)
Occupational airway disease in laboratory animal workers is determined by bronchial hyperresponsiveness to adenosine 5'-monophosphate rather than metacholine. (1998) (0)
Gender differences in the natural history of pulmonary diseases (2003) (0)
Assessing small airways disease (2008) (0)
[The place of long-acting beta 2 adrenergic agonists in the treatment of asthma and chronic obstructive lung disease (COPD)]. (1999) (0)
Peroxynitrite induced airway-hyperresponsiveness in the mouse (1999) (0)
Activity in Lung Epithelial Cells Inflammation in Mice by Suppressing NF-Nuclear Receptor Nur77 Attenuates Airway (2015) (0)
Low agreement between current and long-term asthma control in children: The PACMAN cohort study (2011) (0)
Approach to Unravel the Molecular Mechanisms Underlying Variations in Lung Function (2015) (0)
Genetic Regulation Of Gene Expression Changes In COPD (2016) (0)
Author ' s response to reviews Title : Reliever salbutamol use as a measure of exacerbation risk in chronic obstructive pulmonary disease (2015) (0)
Evaluation of shortened version of the dosimeter method for bronchoprovocation with adenosine-5-monophosphate (AMP) in surveys on occupational asthma. (1995) (0)
The Influence Of Female Sex Hormones On The Number Of Alternatively Activated Lung Macrophages And Airway Inflammation In A Mouse Model Of Asthma (2011) (0)
Lung cancer and COPD: Overlapping origins of disease? (2007) (0)
Gene expression in bronchial biopsies from subjects with persistent asthma and asthma in remission (2017) (0)
THE EFFECTS OF NEDOCROMIL SODIUM ON PULMONARY-FUNCTION, AIRWAY RESPONSIVENESS AND SYMPTOM SCORES IN NONALLERGIC PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE (COPD) (1993) (0)
Interrelationship Between Asthma and Chronic Obstructive Pulmonary Disease (2008) (0)
Protocatherin-1 expression in airwayepithelium: investigations into a novel cause of bronchialhyperresponsiveness and asthma (2009) (0)
EOSINOPHIL NUMBERS AND ACTIVITY IN BLOOD AND BRONCHOALVEOLAR FLUID (BALF) IN NOCTURNAL ASTHMA (1993) (0)
European Respiratory Society Annual Congress 2013 (2013) (0)
Genetic Risk Factors For Chronic Mucus Hypersecretion In Chronic Obstructive Pulmonary Disease (2012) (0)
Peak expiratory flow monitoring in older patients with asthma: An aid to management? (2006) (0)
GWAS Identifies That A Human Plasma Kallikrein Single Nucleotide Polymorphism Regulates Serum PLAUR Levels In Asthma And COPD (2012) (0)
Comparative Effectiveness Of Extrafine Hydrofluoroalkane Beclometasone And Fluticasone In The Real-World Management Of Chronic Obstructive Pulmonary Disease (2012) (0)
Pathogenesis of Chronic Obstructive Pulmonary Disease An Association between Neutrophils and Immunoglobulin Free Light Chains in the (2012) (0)
Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers (2013) (0)
Patterns of asthma medication use in the first eight years of life (2009) (0)
The Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study: novel strategies for prevention of asthma and allergy in children (2006) (0)
Genetic study into respiratory airway disorders in young children: the ALLERGENIC study (2007) (0)
Role of SERPINE2 in Asthma and COPD. (2009) (0)
Faculty Opinions recommendation of Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. (2013) (0)
Identification Of Novel Genes Related To Obstruction Of The Small Airways In Adult Never-Smokers (2016) (0)
The Impact of Acute Smoking on Airway Gene-Expression (2015) (0)
Macrophage subsets in lung tissue of healthy controls and asthma patients (2015) (0)
Detecting Lung Function Decline In Heavy Smokers : Choosing between FEV1/FVC <70% or (2010) (0)
Role Of Wnt4 In The Aberrant Airway Epithelial Response To Cigarette Smoke In COPD (2012) (0)
Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers. Commentary (2007) (0)
The Relation Between Perinatal Factors And Phenotypes Of Wheeze In The First 8 Years Of Life (2010) (0)
Anti-inflammatory drugs in chronic obstructive pulmonary disease (1998) (0)
University of Groningen GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma (2018) (0)
Genetic overlap of airway obstruction and emphysema (2011) (0)
Corrigendum to: “Mast cell numbers in airway smooth muscle and PC20AMP in asthma and COPD” (2007) (0)
Effects of chronic inflammation on lung fibroblasts: expression of cytokine receptors: Leucocyte typing V. White cell differentiation antigens (1995) (0)
CT-scan identified pulmonary changes with smoking and aging in a healthy population (2014) (0)
Groningen SIRT 1 / FoxO 3 axis alteration leads to aberrant immune responses in bronchial epithelial cells (2018) (0)
Impact of age on extra-fine particle hydrofluoroalkane beclometasone dipropionate versus fluticasone propionate outcomes in asthmatic children (2013) (0)
University of Groningen SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells (2018) (0)
No Association Between Cortisol And Presence Or Development Of Asthma In Adolescence. The TRAILS Study (2012) (0)
IsDelayed Introduction ofInhaled Corticosteroids Harmful inPatients With Obstructive Airways Disease (Asthma andCOPD) (2015) (0)
Genetic interaction between ATP2A2 and ORMDL3, a calcium handling origin of asthma (2014) (0)
University of Groningen COPD : recognizing the susceptible smoker (2014) (0)
Variants In The Nicotine Acetylcholine Receptor (CHRNA 3/5) Locus May Play A Role In COPD Development Via Smoking Status (2016) (0)
Airway Gene Expression Is Dynamic With Inhaled Corticosteroid Treatment And Reflects Clinical Response In Patients With COPD (2012) (0)
Skin sensitivity to corticosteroids is associated with COPD susceptibility (2011) (0)
Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics (2018) (0)
Risk factors for the progression of asthma: inflammation and remodelling (2001) (0)
WNT-4 regulates pro-inflammatory responses driven by epithelial-mesenchymal cross-talk (2016) (0)
Assessing small airways disease. Authors' reply (2008) (0)
Long-term treatment in asthma and COPD. (1990) (0)
Obeidat et al. 2013 PLoS ONE (2015) (0)
CT-Based Local Distribution Metric Improves Characterization of COPD (2017) (0)
Chronic obstructive pulmonary disease. (2005) (0)
Oral mucolytic drugs reduce exacerbation from chronic obstructive pulmonary disease and stable chronic bronchitis (2001) (0)
Identification of Protocadherin-1 as a Novel Susceptibility Gene for Bronchial Hyperresponsiveness and Asthma. (2009) (0)
An improved bronchial provocation test with dry powder adenosine instead of nebulised adenosine monophosphate (AMP) (2017) (0)
airway and parenchymal fibroblasts in severe COPD 2 (2013) (0)
De rol van stress in de etiologie van astma: een multidisciplinaire benadering (2008) (0)
PlethysmographicParametersinthe Assessmentof Reversibilityof Airways Obstructionin PatientsWithClinical Emphysema * (2006) (0)
The emerging landscape of dynamic DNA methylation in early childhood (2017) (0)
The Smoke-induced Specific Immune Response Differs Between COPD Patients And Healthy Controls (2010) (0)
microRNA profiling in pulmonary fibroblasts in COPD (2011) (0)
FEV1 Change In The First 2 Months As A Predictor Of Future Outcomes In Moderate-To-Very Severe COPD (2012) (0)
One major locus and one modifier locus control the expression of bronchial hyperresponsiveness. (1997) (0)
A nasal gene expression profile differentiates individuals with and without COPD and overlaps bronchial gene expression (2017) (0)
Budesonide and fluticasone propionate exertdifferential effects on human bronchial epithelial cells exposed tostreptococcus pneumoniaeand viral mimetic (2016) (0)
Chronic obstructive pulmonary disease. (2002) (0)
Inducible Expression Quantitative Trait Loci (2016) (0)
Limited agreement between current and long-term asthma control in children : the PACMAN cohort study (vol 22, pg 776, 2011) (2012) (0)
Factor Analysis On 16 Clinical And Demographic Variables In More Than 6000 COPD Patients (2011) (0)
Boxplots of gene expression levels in the lung for HHIP according to genotype groups for SNP rs1828591. (2013) (0)
AUTHORS' REPLY (1995) (0)
Air pollution exposure is associated with restrictive rather than obstructive ventilatory patterns (2016) (0)
Comparison of three normal breathing techniques to assess reversibility of airway obstruction. (1992) (0)
Chapter 4 - Genetics (2002) (0)
The inhaled corticosteroids questionnaire shortened version (ICQ-S): A brief patient-rated scale for monitoring inhaled corticosteroid side effects in clinical practice (2012) (0)
Macrophage Heterogeneity and Soluble Mediators in Sputum And Bronchoalveolar Lavage from Current Smokers And Ex-smokers With COPD (2010) (0)
Long-term follow-up of asthmatic patients (1996) (0)
BONE TURNOVER AND INHALED CORTICOSTEROIDS. AUTHORS' REPLY (1995) (0)
Interleukin-15 enhances the expression of interferon-γ and interleukin-4 in activated human T lymphocytes by post-transcriptional mechanisms (1996) (0)
Genome Wide Association Study Identifies Locus Determining Genetic Heterogeneity Of Lung Function Decline In Asthmatic And Non-Asthmatic Adults (2011) (0)
Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study (2015) (0)
Detection of Der p1 levels in induced sputum and change during mild exacerbation in atopic asthmatics (1999) (0)
Interaction between the Toll-Like Receptor 4 Gene and Traffic Related Air Pollution in the Development of Asthma in Children (2009) (0)
Effectiveness Of Spacers For The Delivery Of Small Particle (qvar (R)) And Standard Sized Particle (fluticasone Propionate) Inhaled Corticosteroid In Patients With Asthma (2015) (0)
Reply (2011) (0)
University of Groningen Genetics of asthma and atopy (2017) (0)
ActivityReceptor-Dependent Th2 Cell-Promoting Epidermal Growth Factor Bronchial Epithelial Cells Leads to Down-Regulation of E-Cadherin in Human (2007) (0)
Genetic susceptibility for Chronic Bronchitis (2010) (0)
Title : Overweight patterns throughout childhood and cardiometabolic markers in early adolescence Running title : Overweight patterns and cardiometabolic markers (2015) (0)
Haplotype differences in agonist-induced desensitization of the lymphocyte beta(2)-adrenoceptor (beta(2)AR) (2004) (0)
Hyperinflation and health status contribute to 6-minute walk distance in COPD, contrary to airway inflammation (2011) (0)
Biomarker Discovery In Chronic Obstructive Pulmonary Disease (COPD) Using Epithelial Lining Fluid (2011) (0)
The pediatric origine of COPD (2009) (0)
Functional Translation of IL33 Locus Polymorphisms Into Altered Epithelial Cell Function Underlying Asthma (2019) (0)
Lung Cancer Associations Are Enriched For Regulatory Variants In Non-Tumor Lung Tissue (2016) (0)
University of Groningen Integration of mouse and human genome-wide association data identifies KCNIP 4 as an asthma gene (2017) (0)
Acute Effects Of Cigarette Smoking On Neutrophil Activation In Peripheral Blood By Measurement Of Cell Surface Receptors In Healthy Subject And COPD Patients (2011) (0)
Pharmacogenetics in severity of bronchial hyperresponsiveness in asthma (2013) (0)
Importantly, the identified SNPs and their locations indicate separate and distinct regulation of each of the isoforms. These findingscould have importantclinicalimplications for diagnostics, monitoring of severity, and potentially therapeutics for asthma. (2014) (0)
P134 Methacholine challenge to demonstrate therapeutic equivalence of terbutaline via different turbuhaler devices in patients with mild to moderate asthma: appraisal of a phase iii, four-way crossover design (2016) (0)
2 THE ROLE OF EUCAPNIC VOLUNTARY HYPERPNEA IN THE DIAGNOSIS OF EXERCISE-INDUCED VOCAL CORD DYSFUNCTION IN ATHLETES : A PILOT STUDY (2015) (0)
Portelli, Michael A. and Moseley, C. and Stewart, Ceri E. and Postma, Dirkje S. and Howarth, P. and Warner, J.A. and Holloway, J.W. and Koppelman, Gerard H. and Sayers, Ian (2016) Airway and peripheral urokinase (2017) (0)
Differential effect of homozygous haplotypes of the B-2-adrenergic receptor (B(2)AR) and its 5 ' promoter on agonist-induced desensititzation in lymphocytes. (2005) (0)
A search for missing pieces of the puzzle; the development of asthma and atopy. Innate immunity genes and environment (2005) (0)
Extrafine compared to non-extrafine particle ICS in smokers and ex-smokers with asthma (2017) (0)
Small airway disease in asthma: a need for awareness in patients and doctors (2011) (0)
Foreword (1999) (0)
Course and prognosis in patients with chronic airflow obstruction : Possible implications for therapy (1993) (0)
Intermittent versus continuous treatment with inhaled corticosteroids in COPD (1998) (0)
In Asthma, Smoking And Inhaled Corticosteroid Use Are Independently Associated With Higher Histone Deacetylase-2 (HDAC-2) Expression In Bronchial Epithelial Cells (2012) (0)
Inflammatory Markers In Induced Sputum Of Patients With Inflammatory Bowel Disease Are Especially Increased With Active Crohn"s Disease (2011) (0)
Differentially methylated genes related to gestational age are also expressed during fetal lung development (2016) (0)
Correspondence on the paper by Krauss–Etschmann S, Bush A, Bellusci S, et al. (2013) (0)
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD : a pilot study. Commentary (2007) (0)
Gene–Environment Interaction in Asthma (2006) (0)
Characterization of beta-adrenoceptor subtype(s) involved in the regulation of cytokine gene expression in activated human T lymphocytes (1996) (0)
University of Groningen Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1 Brandsma, (2020) (0)
Host-microbial interactions in childhood atopy: TLR4, CD14 and fecal Escherichia coli (2009) (0)
Systems Genetics Approach Identifies Nicotine Receptor Antagonist As A Potential Therapeutic Target In COPD (2015) (0)
Comparison of inflammatory and clinical parameters during one year of stepdown (SD) versus fixed dose therapy (FD) with inhaled fluticasone in asthmatics. (1999) (0)
Transforming Growth Factor Beta Affects Mirna Expression In Control And COPD Fibroblasts (2016) (0)

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