Donald Everett Schmechel
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Philosophy Biology
Donald Everett Schmechel's Degrees
- Masters Medicine University of North Carolina at Chapel Hill
- PhD Neurobiology University of North Carolina at Chapel Hill
Why Is Donald Everett Schmechel Influential?
(Suggest an Edit or Addition)Donald Everett Schmechel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. (1993) (1436)
- Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. (1993) (1329)
- Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells (1978) (736)
- Identification of insulin in rat brain. (1978) (575)
- Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. (2003) (538)
- Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases (1993) (495)
- Neuropeptide-containing neurons of the cerebral cortex are also GABAergic. (1984) (489)
- Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons (2008) (486)
- Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. (1994) (458)
- Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype (1994) (454)
- Production of a specific antiserum to rat brain glutamic acid decar☐ylase by injection of an antigen-antibody complex (1981) (429)
- Brain endolases as specific markers of neuronal and glial cells. (1978) (426)
- Neuron specific enolase, a clinically useful marker for neurons and neuroendocrine cells. (1987) (417)
- Immunocytochemical localization of glutamate decar☐ylase in rat cerebellum with a new antiserum (1981) (414)
- Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. (1994) (412)
- SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. (2000) (367)
- A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes (1979) (358)
- Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation (1980) (342)
- Age at onset in two common neurodegenerative diseases is genetically controlled. (2002) (332)
- Analysis of European mitochondrial haplogroups with Alzheimer disease risk (2004) (283)
- Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. (2008) (258)
- Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. (2007) (247)
- MEASUREMENT OF NEURON‐SPECIFIC (NSE) AND NON‐NEURONAL (NNE) ISOENZYMES OF ENOLASE IN RAT, MONKEY AND HUMAN NERVOUS TISSUE (1979) (234)
- Apoptosis and Delayed Neuronal Damage after Carbon Monoxide Poisoning in the Rat (1997) (224)
- Glutamic acid decarboxylase-immunoreactive neurons and terminals in the lateral geniculate nucleus of the cat (1984) (224)
- Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. (2003) (224)
- Coexistence of glutamic acid decarboxylase- and somatostatin-like immunoreactivity in neurons of the feline nucleus reticularis thalami (1983) (209)
- Variability in the terminations of GABAergic chandelier cell axons on initial segments of pyramidal cell axons in the monkey sensory‐motor cortex (1985) (208)
- Developmental profile of neuron-specific (NSE) and non-neuronal (NNE) enolase (1980) (200)
- Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study (1994) (197)
- Insidious effects of a toxic estuarine dinoflagellate on fish survival and human health. (1995) (187)
- Human Apolipoprotein E2, E3, and E4 Isoform-Specific Transgenic Mice: Human-like Pattern of GlialandNeuronal Immunoreactivity in Central Nervous System Not Observed in Wild-Type Mice (1996) (182)
- GABAergic neurons of mammalian cerebral cortex: Widespread subclass defined by somatostatin content (1984) (175)
- Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. (2006) (161)
- Specific regional transcription of apolipoprotein E in human brain neurons. (1999) (160)
- Altered immune responses in apolipoprotein E-deficient mice. (2000) (154)
- Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration (2005) (153)
- Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls (1994) (152)
- Central GABAergic innervation of neurointermediate pituitary lobe: biochemical and immunocytochemical study in the rat. (1982) (148)
- Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. (2005) (147)
- Blood Platelets Contain a Neuron‐Specific Enolase Subunit (1980) (145)
- Apolipoprotein E Isoform-Specific Differences in Outcome from Focal Ischemia in Transgenic Mice (1998) (141)
- Clinical application of apolipoprotein E genotyping to Alzheimer's disease (1994) (134)
- Cochicine-induced granule cell loss in rat hippocampus: Selective behavioral and histological alterations (1986) (133)
- Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology (2005) (130)
- Cortical relay neurons and interneurons in the N. ventralis posterolateralis of cats: A horseradish peroxidase, electron-microscopic, golgi and immunocytochemical study (1983) (130)
- The distribution of glutamic acid decarboxylase immunoreactivity in the diencephalon of the opossum and rabbit (1984) (115)
- Glutamic acid decarboxylase and somatostatin immunoreactivities in rat visual cortex (1986) (109)
- CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID‐BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE (1988) (108)
- Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis (1983) (107)
- Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage. (2003) (106)
- Opioid peptide-like immunoreactivity localized in GABAErgic neurons of rat neostriatum and central amygdaloid nucleus. (1983) (105)
- AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates (1988) (105)
- Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. (2003) (103)
- Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice (2004) (103)
- Influence of anosognosia on treatment outcome among dementia patients (2001) (100)
- Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. (2005) (94)
- Glutamic acid decarboxylase immunoreactivity in layer IV of barrel cortex of rat and mouse (1985) (91)
- A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment (2013) (89)
- An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease (1999) (88)
- Localization of neuron-specific enolase in mouse spinal neurons grown in tissue culture (1980) (83)
- Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease (1994) (83)
- APOE genotype-specific differences in human and mouse macrophage nitric oxide production (2004) (79)
- Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease (2006) (75)
- Glutamic acid decarboxylase in the striate cortex of normal and monocularly deprived kittens (1985) (73)
- Comparison of cysteine sulphinic acid decar☐ylase isoenzymes and glutamic acid decar☐ylase in rat liver and brain (1981) (71)
- The neurobiology of the brain enolases. (1980) (70)
- Calcium binding proteins distinguish large and small cells of the ventral posterior and lateral geniculate nuclei of the prosimian galago and the tree shrew (Tupaia belangeri). (1993) (69)
- Neuron-specific enolase as an index of neuronal regeneration and reinnervation (1983) (65)
- Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques (1985) (64)
- Glutamic acid decarboxylase-containing neurons in the dorsal column nuclei of the cat. (1984) (61)
- Decrease of glutamate decarboxylase (GAD)-immunoreactive nerve terminals in the substantia nigra after kainic acid lesion of the striatum. (1981) (61)
- Morphological, Biochemical, and Genetic Support for an Apolipoprotein E Effect on Microtubular Metabolism a (1996) (57)
- Analysis of association at single nucleotide polymorphisms in the APOE region. (2000) (56)
- Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra (2005) (53)
- Regionally specific neuronal expression of human APOE gene in transgenic mice (1998) (51)
- Persisting learning deficits in rats after exposure to Pfiesteria piscicida. (1997) (50)
- Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage. (1995) (50)
- Sialylated Human Apolipoprotein E (apoEs) Is Preferentially Associated with Neuron-Enriched Cultures from APOE Transgenic Mice (1999) (50)
- Inhaled carbon monoxide and hyperoxic lung injury in rats. (2001) (49)
- Linkage and Association Study of Late‐Onset Alzheimer Disease Families Linked to 9p21.3 (2008) (48)
- Neuroanatomical correlates of malingered memory impairment: Event-related fMRI of deception on a recognition memory task (2008) (46)
- Production of an antiserum to rat brain glutamate (GAD)/cysteine sulfinate (CSD) decarboxylase (1980) (44)
- A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease (2007) (43)
- The existence and neurobiological significance of neuronal and glial forms of the glycolytic enzyme enolase. (1979) (42)
- Localization of neuron-specific enolase (NSE) mRNA in human brain (1987) (41)
- Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease (2003) (41)
- Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. (1995) (40)
- Vascular Smooth Muscle Actin Is Reduced in Alzheimer Disease Brain: A Quantitative Analysis (2004) (39)
- A computer program to assist in the care of acute respiratory failure (1973) (38)
- An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. (1999) (38)
- Cardiovascular Damage in Alzheimer Disease: Autopsy Findings From the Bryan ADRC (2005) (37)
- Development of GABA-ergic system in rat visual cortex. (1984) (36)
- Proxies and Consent Discussions for Dementia Research (2007) (35)
- Estuary-associated syndrome in North Carolina: an occupational prevalence study. (2000) (34)
- Pfiesteria toxin and learning performance. (1999) (34)
- Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent. (2012) (34)
- GM1 ganglioside attenuates the behavioral deficits but not the granule cell damage produced by intradentate colchicine (1989) (27)
- Age-Dependent Cytokine Responses: Trimethyltin Hippocampal Injury in Wild-Type, APOE Knockout, and APOE4 Mice (2000) (25)
- Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease (2004) (25)
- Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease (2006) (25)
- Creatine kinase brain isoenzyme: relationship of cerebrospinal fluid concentration to the neurologic condition of newborns and cellular localization in the human brain. (1985) (24)
- Art, alpha-1-antitrypsin polymorphisms and intense creative energy: blessing or curse? (2007) (24)
- Localization of glutamate decarboxylase on line-immunoelectrophoresis and two-dimensional electrophoresis by use of the radioactive suicide substrate [2-3H]-gamma-acetylenic GABA. (1980) (24)
- When should functional neuroimaging techniques be used in the diagnosis and management of Alzheimer's dementia? A decision analysis. (2003) (23)
- Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition. (2008) (23)
- Potential human health effects associated with laboratory exposures to Pfiesteria piscicida. (2001) (21)
- Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. (2005) (21)
- Cholinergic Axonal Dystrophy and Mitochondrial Pathology in Prosimian Primates (1996) (21)
- Regulation and genetic control of brain amyloid (1991) (20)
- Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD) (2007) (19)
- Cis-Acting Human ApoE Tissue Expression Element is Associated with Human Pattern of Intraneuronal ApoE in Transgenic Mice (1998) (18)
- Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. (2006) (16)
- Effect of heterogeneity on the chromosome 10 risk in late‐onset Alzheimer disease (2007) (16)
- Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. (1998) (15)
- Pattern of Apolipoprotein E Immunoreactivity During Brain Aging (1996) (14)
- P2-377: A phase 2, double-blind, placebo-controlled study to evaluate the safety, tolerability, and effect on cognitive function of AL-108 after 12 weeks of intranasal administration in subjects with mild cognitive impairment (2008) (13)
- Use of Positron Emission Tomography and Other Neuroimaging Techniques in the Diagnosis and Management of Alzheimer’s Disease and Dementia (2001) (13)
- Human health effects of exposure to Pfiesteria piscicida: a review. (2002) (13)
- The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease (2003) (13)
- Deficiency of α-1-antitrypsin influences systemic iron homeostasis (2013) (13)
- Expression of the amyloid beta-protein precursor gene. (1990) (12)
- A comparative analysis of the information content in long and short SAGE libraries (2006) (11)
- Assessment of Ultrastructural Changes Associated with Apoptosis (1998) (11)
- Increased amyloid , 8-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease ( phenotype / APOE 4 gene ) (2005) (11)
- GABA markers in the hypothalamic median eminence. (1981) (10)
- Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis (2006) (9)
- Differential Distribution of Somatostatin‐like Immunoreactivity in the Visual Sector of the Thalamic Reticular Nucleus in Galago (1991) (9)
- Sequestration of amyloid beta-peptide. (1993) (9)
- Erratum: Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease (Human Molecular Genetics (2003) vol. 12 (3259-3267)) (2004) (8)
- A new double-labeling method demonstrates transmitter-specific projections (1985) (8)
- Association Analysis of Genetic Polymorphisms in the CDC2 Gene with Late-Onset Alzheimer Disease (2006) (6)
- Emotional Reactions to Pain Predict Psychological Distress in Adult Patients with Sickle Cell Disease (SCD) (2014) (6)
- Longitudinal follow‐up of late‐onset Alzheimer disease families (2008) (6)
- Neuropsychological Detection of Preclinical Alzheimer's Disease: Results of a Neuropathological Series of ‘Normal’ Controls (2002) (6)
- No Association between SNP rs498055 on Chromosome 10 and Late‐Onset Alzheimer Disease in Multiple Datasets (2007) (5)
- Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice. (2006) (4)
- Pineal Cells : Culture and Co-Culture with Neurons from the Superior Cervical Ganglia1 (1982) (4)
- Apoptosis in Neurodegenerative Disorders (1998) (4)
- Peptidergic regulation in neuroendocrine and autonomic systems (1984) (3)
- 4. HOX-1.3, AMYLOID BETA -PROTEIN PRECURSOR AND AGING (1991) (2)
- Apolipoprotein E-e4 and apolipoprotein E-e2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer disease (1994) (2)
- Apolipoprotein E and Alzheimer’s Disease: Therapeutic Implications (1994) (2)
- APOLIPOPROTEIN E EPSILON 4. AUTHORS' REPLY (1994) (2)
- Effect of Diet and Targeted Replacement Human APOE Isoforms in Aged Mice (2003) (2)
- Creativity and mental disorder. (2012) (1)
- Model of Genetic Susceptibility to Late-Onset Alzheimer’s Disease: Mice Transgenic for Human Apolipoprotein E Alleles (1999) (1)
- P2-350 Costs associated with increasing severity of dementia — A review of the literature (2004) (1)
- Chapter 4 – METHODS OF LOCALIZING CELL-SPECIFIC PROTEINS IN BRAIN (1988) (1)
- brain human functionally distinct regions of the normal aged Gene expression profiles in anatomically and (2015) (1)
- Vascular abnormalities in APOE4,4 and APOE3,3 Alzheimer's disease (2000) (0)
- P2-298 Effects of a high fat diet on brain lipid levels in human apoE targeted replacement mice (2004) (0)
- Glutamic Acid Decarboxylase in Kitten Striate Cortex. (1985) (0)
- P4-080 Genetic studies of Alzheimer disease on chromosome 9P (2004) (0)
- CLINICAL PROFILE AND OUTCOMES OF ALPHA-1 ANTITRYPSIN DEFICIENCY CARRIERS RECEIVING AUGMENTATION THERAPY IN THE HOME (2018) (0)
- New approaches to therapy for neurodegenerative diseases. (1991) (0)
- P1-345 Evidence for association between late-onset Alzheimer’s disease and MTHFR on chromosome 1 (2006) (0)
- Methods to detect Alzheimer's disease. (1993) (0)
- O1-03-06 Transcription analysis of APOE specific hippocampus in Alzheimer's disease (AD) using serial analysis of gene expression (SAGE) and long-SAGE (2004) (0)
- 217. Apolipoprotein is a susceptibility genetic locus that affects the expression of late-onset familial and sporadic Alzheimer's disease (1996) (0)
- Investigating the Relationship Between Children, Depression, and Pain in Black Women With Sickle Cell Disease (SCD) (2014) (0)
- APOE in Alzheimer ' s disease-T catenin gene ( VR 22 ) α Interaction between the (2005) (0)
- Apolipoprotein E ε4 (1994) (0)
- Central GABAergic innervation of lobe: Biochemical and immunocyto (hypophysis/glutamic acid decarboxylase/y-aminobutyric acid) (2016) (0)
- Apolipoprotein E Transgenic Mouse Model of Cerebral Amyloid Angiopathy (2001) (0)
- Re: Apolipoprotein E ε4 (1994) (0)
- P2-012 Dietary fatty acid source: effects on Aβ, copper and iron metabolism (2004) (0)
- 3in Neurodegenerative Disorders (1999) (0)
- Apolipoprotein (APOE) Allelic Expression, Advanced Age, and Diet Contribute to Atrophic Degenerative Changes in Retinal Ganglion Cells and Optic Nerve in a Mouse Model: Predictors of Severity of Glaucoma? (2005) (0)
- Subjective appraisals of memory functioning in dementia: Validity and cautions (1999) (0)
- Murine choroidal neovascularization: A model for exudative age–related macular degeneration (AMD) (2004) (0)
- P4-072 Follow-up analysis of chromosome 2 linkage in early-onset Alzheimer disease (2004) (0)
- P3-006 Endophenotypes in Alzheimer disease: nutritional, inflammatory and metal indices (2004) (0)
- Characterization of the Natural History of Neovascularization and Basal Deposits in a Non–invasive Murine Model of Age–related Macular Degeneration (2005) (0)
- Targeted human apoE replacement mice provide a model for studying the role of apoE in Alzheimer's disease (2000) (0)
- P3-164 Vascular pathology in patients with dementia (2004) (0)
- Symposium SESSION 5-A. ENVIRONMENTAL MODULATION OF NEUROTOXICANTS IN MILITARY-RELEVANT OPERATIONAL ENVIRONMENTS (2006) (0)
- Verwendunf of ApoE for binding TAU and MAP2c proteins and for the treatment of Alzheimer's disease (1994) (0)
- Production of an antiserum to decarboxylases of glutamate (GAD) and cysteine sulphinate (CSD) from rat brain (1979) (0)
- Contents Vol. 35, 2013 (2013) (0)
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What Schools Are Affiliated With Donald Everett Schmechel?
Donald Everett Schmechel is affiliated with the following schools:
