Donald M. Hilvert

Donald M. Hilvert's AcademicInfluence.com Rankings

Donald M. Hilvert

Chemistry

#3180

World Rank

#4174

Historical Rank

Organic Chemistry

#502

World Rank

#581

Historical Rank

chemistry Degrees

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Chemistry

Donald M. Hilvert's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Donald M. Hilvert's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

De Novo Computational Design of Retro-Aldol Enzymes (2008) (1011)
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction (2010) (759)
Protein design by directed evolution. (2008) (359)
Iterative approach to computational enzyme design (2012) (275)
Directed Evolution of a Protein Container (2011) (270)
Precision is essential for efficient catalysis in an evolved Kemp eliminase (2013) (254)
Directed Evolution of Protein Catalysts. (2018) (245)
Minimalist active-site redesign: teaching old enzymes new tricks. (2007) (226)
Critical analysis of antibody catalysis. (2000) (223)
Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase (2016) (207)
De novo enzymes by computational design. (2013) (201)
Antibody catalysis of the Diels-Alder reaction (1989) (200)
Evolution of a designed retro-aldolase leads to complete active site remodeling (2013) (200)
Investigating and Engineering Enzymes by Genetic Selection. (2001) (182)
Selenosubtilisin as a glutathione peroxidase mimic (1990) (165)
Design of protein catalysts. (2013) (149)
Conversion of a protease into an acyl transferase: selenolsubtilisin (1989) (139)
Robust design and optimization of retroaldol enzymes (2012) (135)
Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. (1994) (134)
A simple tagging system for protein encapsulation. (2006) (131)
An evolution-based model for designing chorismate mutase enzymes (2020) (131)
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. (2012) (131)
A rationally designed aldolase foldamer. (2009) (130)
Redesigning enzyme topology by directed evolution. (1998) (127)
An artificial metalloenzyme for olefin metathesis. (2011) (126)
Biocatalysts by evolution. (2010) (123)
Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis. (1996) (123)
An enzymatic molten globule: efficient coupling of folding and catalysis. (2004) (120)
Large rate accelerations in antibody catalysis by strategic use of haptenic charge (1995) (117)
Selenoglutathione: efficient oxidative protein folding by a diselenide. (2007) (116)
Catalysis of concerted reactions by antibodies: the Claisen rearrangement. (1988) (111)
Structure and dynamics of a molten globular enzyme (2007) (102)
A photoinducible beta-hairpin. (2005) (98)
Efficient in vitro encapsulation of protein cargo by an engineered protein container. (2012) (97)
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase (2014) (97)
Kinetic studies on the peroxidase activity of selenosubtilisin. (1993) (96)
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. (1999) (96)
Quantitative Packaging of Active Enzymes into a Protein Cage. (2016) (94)
An Active Enzyme Constructed from a 9-Amino Acid Alphabet* (2005) (94)
Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation. (2003) (94)
Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis (1985) (91)
Evolution of a highly active and enantiospecific metalloenzyme from short peptides (2018) (86)
Is chorismate mutase a prototypic entropy trap? - Activation parameters for the Bacillus subtilis enzyme (1996) (85)
Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle. (2008) (83)
A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii. (1998) (82)
Speeding up enzyme discovery and engineering with ultrahigh-throughput methods. (2018) (81)
Kinetic characterization of spiropyrans in aqueous media. (2009) (80)
Facile, fmoc-compatible solid-phase synthesis of peptide C-terminal thioesters. (2000) (79)
Stereospecific Claisen rearrangement catalyzed by an antibody (1988) (79)
Structure and assembly of scalable porous protein cages (2017) (79)
Fmoc-Compatible Solid-Phase Peptide Synthesis of Long C-Terminal Peptide Thioesters The authors are grateful to the ETH-Zürich and Novartis Pharma AG for support of this work. Fmoc=9-fluorenylmethoxycarbonyl. (2001) (79)
On the relationship between folding and chemical landscapes in enzyme catalysis (2008) (78)
Reprogramming nonribosomal peptide synthetases for "clickable" amino acids. (2014) (78)
Enzyme Encapsulation by a Ferritin Cage. (2017) (75)
Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis (2005) (75)
Consensus protein design without phylogenetic bias. (2010) (72)
Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor. (2003) (71)
Heavy Atom Isotope Effects Reveal a Highly Polarized Transition State for Chorismate Mutase (1999) (70)
Structural characterization of selenosubtilisin by selenium-77 NMR spectroscopy (1992) (70)
Strategic use of non-native diselenide bridges to steer oxidative protein folding. (2012) (70)
A subdomain swap strategy for reengineering nonribosomal peptides. (2015) (69)
Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme. (2016) (69)
Searching sequence space for protein catalysts (2001) (68)
Kinetics and thermodynamics of ligand binding to a molten globular enzyme and its native counterpart. (2008) (67)
Nonribosomal biosynthesis of backbone-modified peptides. (2018) (67)
Natural and synthetic selenoproteins. (2014) (66)
Hydrolytic antibodies: variations on a theme. (1996) (66)
Isochorismate pyruvate lyase: a pericyclic reaction mechanism? (2005) (65)
Capture and characterization of a reactive haem–carbenoid complex in an artificial metalloenzyme (2018) (65)
Three New Chiral Aminoethers from Tartaric Acid for Improved Asymmetric Syntheses with Organolithium Reactions. Preliminary communication (1979) (64)
A simple selection strategy for evolving highly efficient enzymes (2007) (64)
Bottom-up Construction of a Primordial Carboxysome Mimic. (2016) (63)
Relative tolerance of mesostable and thermostable protein homologs to extensive mutation (2006) (63)
In vivo catalysis of a metabolically essential reaction by an antibody. (1991) (62)
Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine (2009) (61)
The putative Diels-Alderase macrophomate synthase is an efficient aldolase. (2008) (61)
Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes. (2017) (60)
Selection of Linkers for a Catalytic Single-chain Antibody Using Phage Display Technology* (1996) (59)
Ultrahigh-throughput screening enables efficient single-round oxidase remodelling (2019) (59)
A Strategically Positioned Cation Is Crucial for Efficient Catalysis by Chorismate Mutase* (2000) (59)
Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles. (2004) (58)
Crystal structure of selenosubtilisin at 2.0-A resolution. (1993) (58)
Tailoring lumazine synthase assemblies for bionanotechnology. (2018) (57)
Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate β2-microglobulin amyloid assembly (2013) (57)
Characterization of Proton-Transfer Catalysis by Serum Albumins (2000) (56)
Functionalized cyclodextrins as holoenzyme mimics of thiamine-dependent enzymes (1984) (55)
Catalysis of oxidative protein folding by small-molecule diselenides. (2008) (55)
Mechanistic Insights into the Isochorismate Pyruvate Lyase Activity of the Catalytically Promiscuous PchB from Combinatorial Mutagenesis and Selection* (2005) (54)
A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold. (2018) (54)
Albumin-Catalyzed Proton Transfer (1996) (53)
Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. (2011) (53)
Peroxide dependence of the semisynthetic enzyme selenosubtilisin. (1993) (53)
Rational Engineering of a Designed Protein Cage for siRNA Delivery. (2018) (52)
Protein conformational disorder and enzyme catalysis. (2013) (52)
Chemoenzymatic synthesis of differentially protected 3-deoxysugars (2010) (51)
Diffusion-Limited Cargo Loading of an Engineered Protein Container. (2015) (49)
Structural origins of efficient proton abstraction from carbon by a catalytic antibody. (2005) (48)
Construction of Matryoshka-type structures from supercharged protein nanocages. (2015) (47)
Medium effects in antibody-catalyzed reactions (1991) (47)
Modulating PNA/DNA hybridization by light. (2010) (46)
A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme. (2016) (46)
Thermodynamics of the Conversion of Chorismate to Prephenate: Experimental Results and Theoretical Predictions (1997) (45)
Laboratory evolution of virus-like nucleocapsids from nonviral protein cages (2018) (45)
Selenocysteine-mediated backbone cyclization of unprotected peptides followed by alkylation, oxidative elimination or reduction of the selenol. (2002) (45)
Enrichment for RNA molecules that bind a Diels-Alder transition state analog. (1994) (44)
A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates. (2015) (43)
How directed evolution reshapes energy landscapes in enzymes to boost catalysis (2020) (43)
Yeast expression of a catalytic antibody with chorismate mutase activity. (1991) (43)
Substrate Sorting by a Supercharged Nanoreactor (2017) (43)
Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase. (2007) (42)
Bacillus subtilis chorismate mutase is partially diffusion-controlled. (1999) (42)
Selenoglutaredoxin as a Glutathione Peroxidase Mimic (2008) (41)
Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting. (2016) (40)
Building proficient enzymes with foldamer prostheses. (2014) (39)
Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: comparative studies of the pH dependencies of the native and Phe-248-mutant forms (1986) (38)
The road to fully programmable protein catalysis (2022) (38)
Efficientin VivoSynthesis and Rapid Purification of Chorismic Acid Using an EngineeredEscherichia coliStrain (1997) (38)
Incorporation of selenomethionine into proteins through selenohomocysteine-mediated ligation. (2003) (37)
Probing the role of the C-terminus of Bacillus subtilis chorismate mutase by a novel random protein-termination strategy. (2000) (37)
Improved synthesis of C-terminal peptide thioesters on "safety-catch" resins using LiBr/THF. (2001) (37)
Transition State of the Base-Promoted Ring-Opening of Isoxazoles. Theoretical Prediction of Catalytic Functionalities and Design of Haptens for Antibody Production (1996) (37)
3D structural information as a guide to protein engineering using genetic selection. (1997) (36)
Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS (2003) (36)
Diselenides as universal oxidative folding catalysts of diverse proteins. (2010) (36)
Virus-Inspired Function in Engineered Protein Cages. (2019) (36)
Monitoring Catalytic Activity by Immunoassay: Implications for Screening (1994) (35)
Site‐Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract (2016) (35)
Harnessing selenocysteine reactivity for oxidative protein folding† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc02379j Click here for additional data file. (2014) (34)
ELECTROSTATIC CATALYSIS OF THE CLAISEN REARRANGEMENT : PROBING THE ROLE OFGLU78 IN BACILLUS SUBTILIS CHORISMATE MUTASE BY GENETIC SELECTION (1996) (34)
Stereoselectivity and expanded substrate scope of an engineered PLP-dependent aldolase. (2006) (32)
Shape Complementarity, Binding‐Site Dynamics, and Transition State Stabilization: A Theoretical Study of Diels–Alder Catalysis by Antibody 1E9 (2000) (32)
Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase. (2017) (32)
A photoswitchable miniprotein based on the sequence of avian pancreatic polypeptide. (2006) (32)
Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site. (2005) (31)
Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein (2020) (31)
Probing enzyme quaternary structure by combinatorial mutagenesis and selection (1998) (31)
Experimental and computational investigation of the uncatalyzed rearrangement and elimination reactions of isochorismate. (2006) (30)
Modular Protein Cages for Size-Selective RNA Packaging in Vivo. (2018) (30)
Relative tolerance of an enzymatic molten globule and its thermostable counterpart to point mutation. (2008) (30)
Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. (2014) (30)
Isotope effects on the enzymatic and nonenzymatic reactions of chorismate. (2005) (29)
Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code (2013) (28)
Antibody catalysis of carbon-carbon bond formation and cleavage (1993) (28)
Engineered Metalloenzymes with Non-Canonical Coordination Environments. (2018) (28)
Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis (2014) (28)
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold (2021) (28)
Irreversible Cysteine-Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents. (2017) (27)
1H NMR spectroscopic studies of selenosubtilisin. (1993) (27)
Charge optimization increases the potency and selectivity of a chorismate mutase inhibitor. (2003) (27)
Surface-Engineered Cationic Nanocrystals Stable in Biological Buffers and High Ionic Strength Solutions (2017) (27)
Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies (2019) (27)
Emergence of a negative activation heat capacity during evolution of a designed enzyme. (2019) (27)
Use of molecular dynamics in the design and structure determination of a photoinducible beta-hairpin. (2005) (27)
Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity (1998) (27)
Evolution of dynamical networks enhances catalysis in a designer enzyme (2020) (27)
Binding of a high-energy substrate conformer in antibody catalysis. (1993) (26)
An Antibody-Catalyzed Selenoxide Elimination (1997) (26)
Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases. (2017) (26)
Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction. (2018) (26)
Synthesis of3-Peptides and Mixeda/3-Peptides by Thioligation (2002) (26)
Synthesis of beta-hydroxy-alpha-amino acids with a reengineered alanine racemase. (2008) (25)
alpha-Functionalized phosphonylphosphinates: synthesis and evaluation as transcarbamoylase inhibitors. (1999) (25)
An Antibody-Catalyzed Allylic Sulfoxide-Sulfenate Rearrangement. (1999) (25)
Convergent protein synthesis. (2003) (25)
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion (2020) (24)
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket (2009) (24)
Synthesis and application of an azobenzene amino acid as a light-switchable turn element in polypeptides (2007) (24)
Small-molecule diselenides catalyze oxidative protein folding in vivo. (2010) (24)
Upregulation of an Artificial Zymogen by Proteolysis. (2016) (23)
Metabolic engineering of a genetic selection system with tunable stringency (2007) (23)
Carbon kinetic isotope effects on the spontaneous and antibody-catalyzed decarboxylation of 5-nitro-3-carboxybenzisoxazole (1993) (23)
Two-tier supramolecular encapsulation of small molecules in a protein cage (2020) (23)
An N-terminal protein degradation tag enables robust selection of highly active enzymes. (2011) (22)
Evidence for the general base mechanism in carboxypeptidase A-catalyzed reactions: partitioning studies on nucleophiles and H2(18)O kinetic isotope effects. (1983) (22)
Investigation of ligand binding and protein dynamics in Bacillus subtilis chorismate mutase by transverse relaxation optimized spectroscopy-nuclear magnetic resonance. (2005) (22)
Selenoglutathione‐Mediated Rescue of Kinetically Trapped Intermediates in Oxidative Protein Folding (2011) (22)
Molecular dynamics simulations highlight mobile regions in proteins: A novel suggestion for converting a murine V(H) domain into a more tractable species. (2000) (21)
Enzyme-mediated polymerization inside engineered protein cages. (2016) (21)
Active Site Plasticity of a Computationally Designed Retro‐Aldolase Enzyme (2014) (21)
A monofunctional and thermostable prephenate dehydratase from the archaeon Methanocaldococcus jannaschii. (2006) (21)
Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A. (1987) (21)
DNA Nanoparticles for Improved Protein Synthesis In Vitro (2016) (20)
Design, selection, and characterization of a split chorismate mutase (2010) (20)
Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis. (2016) (19)
Simultaneous optimization of enzyme activity and quaternary structure by directed evolution (2005) (19)
Diversification of Protein Cage Structure Using Circularly Permuted Subunits. (2018) (18)
A computational method for design of connected catalytic networks in proteins (2019) (18)
Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM. (2016) (18)
Bifunctional catalysis of proton transfer at an antibody active site. (2007) (18)
Novel enzymes through design and evolution. (2007) (18)
Chiral recognition in amyloid fiber growth (2016) (18)
Analysis of solvent effects on the decarboxylation of benzisoxazole-3-carboxylate ions using linear solvation energy relationships : relevance to catalysis in an antibody binding site (1993) (18)
Self-Assembly of Proteinaceous Multishell Structures Mediated by a Supercharged Protein. (2016) (17)
Semisynthetic enzymes: design of flavin-dependent oxidoreductases. (1987) (17)
Harnessing protein symmetry for enzyme design (2012) (17)
Chemoselective Henry Condensations Catalyzed by Artificial Carboligases. (2017) (17)
A novel genetic selection system for PLP-dependent threonine aldolases (2012) (17)
Direct NMR observation and DFT calculations of a hydrogen bond at the active site of a 44 kDa enzyme (2002) (16)
A Genetically Encodable Ligand for Transfer Hydrogenation (2013) (16)
Nonessential active site residues modulate selenosubtilisin's kinetic mechanism. (1995) (16)
Investigation of Medium Effects in a Family of Decarboxylase Antibodies (1994) (16)
Toward bifunctional antibody catalysis. (2006) (15)
Deciphering enzymes. Genetic selection as a probe of structure and mechanism. (2004) (15)
Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting. (2017) (15)
The Chemistry of Selenocysteine (2011) (15)
Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. (2000) (15)
Genetic selection strategies for generating and characterizing catalysts (1996) (15)
Trapping and structural elucidation of an intermediate in the macrophomate synthase reaction pathway. (2007) (14)
Substitution of proline32 by α-methylproline preorganizes β2-microglobulin for oligomerization but not for aggregation into amyloids. (2015) (14)
Catalysis on the coastline: Theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5‐nitro‐3‐carboxybenzisoxazole (2003) (14)
Extending the chemistry of enzymes and abzymes. (1991) (14)
Structures and function of the amino acid polymerase cyanophycin synthetase (2021) (14)
A highly active thermophilic semisynthetic flavoenzyme (1988) (14)
New semisynthetic flavoenzymes based on a tetrameric protein template, glyceraldehyde-3-phosphate dehydrogenase (1985) (13)
Comparative Laboratory Evolution of Ordered and Disordered Enzymes*♦ (2015) (13)
Promiscuity in Antibody Catalysis: Esterolytic Activity of the Decarboxylase 21D8 (2003) (12)
Conformational Isomerism Can Limit Antibody Catalysis* (2008) (11)
Sequence Similarity and Cross-Reactivity of a Diels–Alder Catalyst and an Anti-Progesterone Antibody (1996) (11)
Cell-Specific Delivery Using an Engineered Protein Nanocage. (2021) (11)
Bioorganic chemistry: A chemical approach to enzyme action: by Herman Dugas. Third edition, Springer-Verlag, New York, 1996, 700 pp. $49.95 (Hardcover) ISBN 0-387-94494-X (1996) (11)
Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiency (2020) (11)
Cell Penetration, Herbicidal Activity, and in-vivo-Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin. (2018) (11)
13C isotope effect on the reaction catalyzed by prephenate dehydratase. (2010) (11)
Reinvestigation of a Selenopeptide with Purportedly High Glutathione Peroxidase Activity* (2007) (11)
Kinetic consequences of introducing a proximal selenocysteine ligand into cytochrome P450cam. (2015) (11)
The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase (2017) (11)
An antibody that reconstitutes the "base-on" form of B(12) coenzymes. (2002) (11)
Protein Cages: From Fundamentals to Advanced Applications. (2022) (11)
Photolyase-like repair of psoralen-crosslinked nucleic acids. (2011) (10)
Investigation of the enzymatic and nonenzymatic cope rearrangement of carbaprephenate to carbachorismate. (2002) (10)
Capture and characterization of a reactive haem-carbenoid complex in an artificial metalloenzyme (2018) (10)
Electric fields in active sites: substrate switching from null to strong fields in thiol- and selenol-subtilisins. (1999) (10)
Preparation of the β3‐Homoselenocysteine Derivatives Fmoc‐β3hSec(PMB)‐OH and Boc‐β3hSec(PMB)‐OH for Solution and Solid‐Phase‐Peptide Synthesis and Selenoligation (2007) (10)
Chemoenzymatic Synthesis of Isotopically Labeled Chorismic Acids. (1999) (10)
Immunological Optimization of a Generic Hydrophobic Pocket for High Affinity Hapten Binding and Diels–Alder Activity (2004) (10)
Syntheses of Cyanophycin Segments for Investigations of Cell-Penetration (2018) (9)
Enzyme Encapsulation in an Engineered Lumazine Synthase Protein Cage. (2018) (9)
New enzymes from combinatorial library modules. (2004) (9)
Engineered artificial carboligases facilitate regioselective preparation of enantioenriched aldol adducts. (2020) (9)
Tunnel plasticity and quaternary structural integrity of a pentameric protein ring (2006) (8)
Closely related antibody receptors exploit fundamentally different strategies for steroid recognition (2008) (8)
Probing an acyl enzyme of selenosubtilisin by raman spectroscopy (1996) (8)
cis-trans Peptide-Bond Isomerization in alpha-Methylproline Derivatives (2012) (8)
Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide. (2014) (8)
Minimalist Active‐Site Redesign: Teaching Old Enzymes New Tricks (2007) (7)
Stereospecific Claisen Rearrangement Catalyzed by an Antibody. (1988) (7)
Noncanonical heme ligands steer carbene transfer reactivity in an artificial metalloenzyme. (2021) (7)
Evolution of the Chemical Step in Enzyme Catalysis (2021) (7)
Evolution-based design of chorismate mutase enzymes (2020) (6)
Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism. (2002) (6)
Non-uniform HYSCORE: Measurement, processing and analysis with Hyscorean. (2019) (6)
Self‐Assembly of Proteinaceous Shells around Positively Charged Gold Nanomaterials Enhances Colloidal Stability in High‐Ionic‐Strength Buffers (2020) (6)
Selenosubtilisin's peroxidase activity does not require an intact oxyanion hole (1997) (6)
Catalysis of 3‐Carboxy‐1,2‐benzisoxazole Decarboxylation by Hydrophobic Antibody Binding Pockets (2000) (6)
Biosynthetic Functionalization of Nonribosomal Peptides. (2021) (6)
De novo chemoenzymatic synthesis of sialic acid. (2012) (6)
Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition state analog (1994) (6)
A cryptic third active site in cyanophycin synthetase creates primers for polymerization (2022) (5)
Mechanistic studies of an antibody with chorismate mutase activity (1994) (5)
Teaching old enzymes new tricks (2010) (5)
Trapping Transient Protein Species by Genetic Code Expansion (2020) (5)
Reprogramming Nonribosomal Peptide Synthesis by Surgical Mutation (2019) (5)
Switching antibody specificity through minimal mutation. (2008) (5)
Steric and Electronic Effects on an Antibody‐Catalyzed Diels–Alder Reaction (2002) (5)
Chemical synthesis of proteins. (1994) (5)
Antibody catalysis via strategic use of haptenic charge. (1996) (4)
Tailor-made peptide synthetases. (2011) (4)
Antibody catalysis (1992) (4)
Synthesis and characterization of catalytically active thiazolium gold(i)-carbenes. (2017) (4)
Structure and Function of the β-Asp-Arg Polymerase Cyanophycin Synthetase 2. (2022) (4)
The OP Protein Cage: A Versatile Molecular Delivery Platform. (2021) (4)
Optimized production of the Diels-Alderase antibody 1E9 as a chimeric Fab (2002) (4)
Chapter 5:Selenocysteine as a Probe of Oxidative Protein Folding (2008) (4)
Antibody catalysis of concerted, carbon-carbon bond-forming reactions. (1991) (4)
De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist (2021) (4)
Structural characterization of selenosubtilisin by sup 77 Se-NMR spectroscopy (1991) (4)
Equipping in vivo Selection Systems with Tunable Stringency (2011) (4)
Genetic selection as a tool in mechanistic enzymology and protein design. (2000) (4)
An Antibody‐Catalyzed Selenoxide Elimination. (1997) (3)
Analysis of electrostatic coupling throughout the laboratory evolution of a designed retroaldolase (2021) (3)
Active site mutagenesis of the putative Diels-Alderase macrophomate synthase. (2007) (3)
Whi3 mnemon association with endoplasmic reticulum membranes confines the memory of deceptive courtship to the yeast mother cell (2020) (3)
Synthesis of β-Hydroxy-α-amino Acids with a Reengineered Alanine Racemase. (2009) (3)
The structure of cyanophycinase in complex with a cyanophycin degradation intermediate. (2022) (2)
Antibody catalysis of carbon-carbon bond formation. (2007) (2)
High-Mass MALDI-MS Analysis for the Investigation of Protein Encapsulation within an Engineered Capsid Forming Protein (2017) (2)
Genetic selection as a probe of structure and mechanism (2004) (2)
Redesign of Protein Function: A Semisynthetic Selenoenzyme (1991) (2)
Mimicking Enzymes with Antibodies (2006) (2)
[Structure and Self-assembly of Negatively Supercharged Protein Cages]. (2019) (1)
Studies on zinc enzymes and models (1983) (1)
Kinetic studies on the peroxidase activity of selenosubtilisin. [Erratum to document cited in CA119(1):3765q] (1993) (1)
AN ACTIVE ENZYME CONSTRUCTED FROM A NINE AMINO ACID ALPHABET (2005) (1)
Post‐Assembly Modification of Protein Cages by Ubc9‐Mediated Lysine Acylation (2022) (1)
Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of α-Hydroxy Acids. (2022) (1)
Enzyme Engineering (2001) (1)
Proceedings du 23ème Conseil Solvay de Chimie "New Chemistry and New Opportunities from the Expanding Protein Universe": World Scientific Publishing (2014) (1)
Using Evolutionary Strategies to Investigate the Structure and Function of Chorismate Mutases (2003) (1)
AN EFFICIENT PREPARATION OF TETRAMETHYLALLENE (1981) (1)
Antibody Catalysis of Carbon‐Carbon Bond Formation and Cleavage. (1994) (0)
Kemp Eliminase HG3.17 mutant Q50S, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2020) (0)
Cyanophycin synthetase 1 from Synechocystis sp. UTEX2470 with ATP and 8x(Asp-Arg)-Asn (2021) (0)
Directed evolution of enzyme structure and function (2003) (0)
Creation and Optimization of Artificial Enzymes for Abiological Reactions (2015) (0)
Crystal structure of an engineered TycA variant in complex with an beta-Phe-AMP analog (2017) (0)
S 1 Supporting Information for Enzyme-mediated polymerization inside engineered protein cages (2016) (0)
A Biocatalytic Diels-Alder Reaction Using a DesignedEnzyme (2011) (0)
Antibody Catalysis via Strategic Use of Haptenic Charge (1996) (0)
Structure of the engineered retro-aldolase RA95.5-8F with a bound 1,3-diketone inhibitor (2016) (0)
Generation of Novel Protein Receptors. (1994) (0)
Genetic Selection for Improved Abzymes in E. Coli (1994) (0)
Crystal structure of a de novo retro-aldolase catalyzing asymmetric Michael additions, with a covalently bound product analog (2015) (0)
Design and optimization of enzymatic activity in a de novo β‐barrel scaffold (2022) (0)
Structure of Mb NMH H64V, V68A mutant complex with EDA (2018) (0)
Mutagenesis and Selection Promiscuous PchB from Combinatorial Catalytically Pyruvate Lyase Activity of the Mechanistic Insights into the Isochorismate Enzyme Catalysis and Regulation (2013) (0)
Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency (2020) (0)
MECHANISTIC ENZYMOLOGY AND CATALYST DESIGN (2014) (0)
Crystal Structure of Kemp Eliminase HG3.17 E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2013) (0)
Crystal structure of Diels-Alderase CE11 (2014) (0)
THREE NEW CHIRAL AMINO ETHERS FROM TARTARIC ACID FOR IMPROVED ASYMMETRIC SYNTHESES WITH ORGANOLITHIUM REACTIONS. PRELIMINARY COMMUNICATION (1980) (0)
Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR184 (2013) (0)
Noncanonical Heme Ligands Steer Carbene Transfer Reactivity in an Artificial Metalloprotein (2021) (0)
Kemp Eliminase HG3.17 mutant Q50H, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2020) (0)
Antibody-Catalyzed Concerted Chemical Reactions (1991) (0)
Structure of AaLS-neg (2017) (0)
The Interplay of Catalytic Activity and Substrate Promiscuity for an Intrinsically Disordered Staphylococcal Nuclease (2012) (0)
Terbium(III)-bound de novo TIM barrel-ferredoxin fold fusion dimer with 4-glutamate binding site and tryptophan antenna (TFD-EE N6W) (2020) (0)
Antibodies: specificity and promiscuity of ligand recognition (2006) (0)
Heme-carbene complex in myoglobin H64V/V68A containing an N-methylhistidine as the proximal ligand, 1.6 angstrom resolution (2018) (0)
Structure and function of a hexameric cyanophycin synthetase 2 (2023) (0)
Myoglobin H64V/V68A in the resting state, 1.5 Angstrom resolution (2018) (0)
CRYSTAL STRUCTURE ANALYSIS OF CHORISMATE MUTASE MUTANT C88K/R90S (2000) (0)
De novo TIM barrel-ferredoxin fold fusion homodimer with 2-histidine 2-glutamate centre TFD-HE (2020) (0)
1997 PEDIATRIC ACADEMIC SOCIETIES ’ ANNUAL MEETING SPONSORED BY THE AMERICAN PEDIATRIC Socnrr S 0 cIE ’ rY FOR PEDIATRIC RESEARCH AND AMULATORY PEDIATRIC ASSOCIATION (2004) (0)
engineered ascorbate peroxidise (2017) (0)
Structure of the engineered retro-aldolase RA95.5-5 (2012) (0)
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-3 (2021) (0)
Overview of amino acid substitutions at mutation hot spots for cassette mutagenesis libraries. (2013) (0)
Frontispiece: Engineered Metalloenzymes with Non‐Canonical Coordination Environments (2018) (0)
X-ray diffraction data for the structure of the engineered metalloesterase MID1sc9 (5OD9) (2017) (0)
Kemp Eliminase HG3.17 mutant Q50F, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2020) (0)
Kemp Eliminase HG3.17 mutant Q50M, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2020) (0)
Ferric camphor bound Cytochrome P450cam, Arg365Leu, Glu366Gln, monoclinic crystal form (2009) (0)
Preparation and Properties of Semisynthetic Flavoenzymes (1986) (0)
Investigating and Engineering Enzymes by Genetic Selection (2001) (0)
Arg90Cit chorismate mutase of Bacillus subtilis at 1.6 A resolution (2014) (0)
Supercharged ferritin as a cell delivery platform (2013) (0)
Catalytic Antibody Technology (2008) (0)
trans-(4-aminomethyl)phenylazobenzoic acid-aPP bound to DPC micelles (2006) (0)
Crystal structure of Kemp Eliminase HG3.17 at 343 K (2020) (0)
Evolution of energy landscapes in designer enzymes. (2023) (0)
Ferric camphor bound Cytochrome P450cam containing a selenocysteine as the 5th heme ligand, orthorombic crystal form (2009) (0)
New Biocatalysts via Chemical Modification (2007) (0)
Discussions of Session 2 (2014) (0)
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-1 (180-mer) (2021) (0)
Noncanonical Heme Ligands Steer Carbene Transfer Reactivity in an Artificial Metalloenzyme** (2021) (0)
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-4 (2021) (0)
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-2 (180-mer) (2021) (0)
Cofactor-Assisted Antibody Catalysis. (1994) (0)
Structure of the engineered metalloesterase MID1sc10 complexed with a phosphonate transition state analogue (2018) (0)
Crystal structure of Kemp Eliminase HG3 K50Q in complex with the transition state analog 6-nitrobenzotriazole (2020) (0)
Arg90Cit chorismate mutase of Bacillus subtilis in complex with chorismate and prephenate (2014) (0)
Reaction mechanism of chorismate mutase, a model enzyme for pericyclic reactions, finally resolved (2012) (0)
Design of enzymatic catalysts (1990) (0)
Crystal structure of Diels-Alderase CE20 in complex with a product analog (2014) (0)
Catalysis of 3‐Carboxy‐1,2‐benzisoxazole Decarboxylation by Hydrophobic Antibody Binding Pockets. (2000) (0)
cis-Azobenzene-avian pancreatic polypeptide bound to DPC micelles (2006) (0)
Structure of the engineered metalloesterase MID1sc9 (2018) (0)
cis-4-aminomethylphenylazobenzoic acid-avian pancreatic polypeptide (2006) (0)
Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog (2017) (0)
Structure of the engineered retro-aldolase RA95.5-8F F112L (2020) (0)
Design and evolution of artificial enzymes (2017) (0)
5.17 – Catalysis by Antibodies (1999) (0)
Structure of Mb NMH H64V, V68A mutant complex with EDA incubated at room temperature for 5 min (2018) (0)
Kemp Eliminase HG3.17 mutant Q50K, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2020) (0)
Wild-type chorismate mutase of Bacillus subtilis at 1.6 A resolution (2014) (0)
Heme-carbene complex in myoglobin H64V/V68A containing an N-methylhistidine as the proximal ligand, 1.48 angstrom resolution (2018) (0)
sperm whale myoglobin mutant (H64V V64A) bearing the non-canonical amino acid 3-thienylalanine as axial heme ligand (2021) (0)
Arg90Cit chorismate mutase of Bacillus subtilis in complex with a transition state analog (2014) (0)
Backbone 1H, 15N, and 13C Chemical Shift Assignments for the Apo-State of Kemp Eliminase HG3.17 (2020) (0)
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-1 (120-mer) (2021) (0)
Crystal structure of Kemp Eliminase HG3.7 in complex with the transition state analog 6-nitrobenzotriazole (2020) (0)
Crystal structure of Kemp Eliminase HG3 (2020) (0)
Crystal structure of Kemp Eliminase HG3.17 in the inactive state (2020) (0)
Structure of the engineered retro-aldolase RA95.5-8F apo (2016) (0)
Biochemical Characterization of Flavodoxin-Like Protein from Hyper-Thermophilic Bacterium Aquifex aeolicus (2002) (0)
Inside Cover: Irreversible Cysteine‐Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents (Chem. Eur. J. 27/2017) (2017) (0)
sperm whale myoglobin mutant (H64V V64A) bearing the non-canonical amino acid 2-Amino-3-(thiazol-5-yl)propanoic acid as axial heme ligand (2021) (0)
Evolution of a computationally designed Kemp eliminase (2019) (0)
Principles of Antibody Catalysis (1996) (0)
Catalytic Antibodies: Perspectives and Prospects (1990) (0)
Engineered Nonviral Protein Cages Modified for MR Imaging (2023) (0)
Stereoselective Reactions with Catalytic Antibodies (2007) (0)
Structure of the engineered metallo-Diels-Alderase DA7 W16S (2021) (0)
Structure of AaLS-13 (2017) (0)
Supporting Online Material for Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction (2010) (0)
Engineering Enzymes and Antibodies (1992) (0)
Crystal structure of Kemp Eliminase HG3.17 in complex with the transition state analog 6-nitrobenzotriazole (2020) (0)
Structure of Mb NMH H64V, V68A mutant resting state (2018) (0)
An artificial metalloenzyme for a bimolecular Diels–Alder reaction (2019) (0)
The enzyme mechanism of a de novo designed and evolved aldolase (2017) (0)
Crystal structure of Kemp Eliminase HG3 in complex with the transition state analog 6-nitrobenzotriazole (2020) (0)
Kemp Eliminase HG3.17 mutant Q50A, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2020) (0)
Nearer to nature: design and optimization of artificial enzymes (2016) (0)
Structure of Mb NMH H64V, V68A mutant complex with EDA incubated at room temperature for 20 min (2018) (0)
Enhancing promiscuous chemistries of a Schiff-base forming enzyme by divergent evolution. (2020) (0)
Structure of the engineered metallo-Diels-Alderase DA7 W16G,K58Q,L77R,T78R (2021) (0)
Positively supercharged variant of the computationally designed cage protein O3-33 (2018) (0)
Crystal Structure of Retro-aldolase RA110.4-6 Complexed with Inhibitor 1-(6-methoxy-2-naphthalenyl)-1,3-butanedione (2014) (0)
Crystal structure of Kemp Eliminase HG3 K50Q (2020) (0)
De novo TIM barrel-ferredoxin fold fusion homodimer with 4-glutamate centre TFD-EE (2020) (0)
TOP-DOWN AND BOTTOM-UP APPROACHES FOR ELUCIDATING THE ORIGINS OF ENZYME EFFICIENCY (2018) (0)
Crystal structure of Kemp Eliminase HG3.17 (2020) (0)
Cyanophycin synthetase 1 from Synechocystis sp. UTEX2470 with ADPCP and 8x(Asp-Arg)-NH2 (2021) (0)
Oxidative protein folding catalyzed by a selenocysteine variant of DsbA (2010) (0)

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What Schools Are Affiliated With Donald M. Hilvert?

Donald M. Hilvert is affiliated with the following schools:

ETH Zurich
University of California, Los Angeles
University of Colorado
University of Washington
University of Zurich