Donald Patrick Mcdonnell

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#1760

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#2134

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Pharmacology

#164

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#203

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Donald Patrick Mcdonnell's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cloning and expression of full-length cDNA encoding human vitamin D receptor. (1988) (904)
The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1. (1999) (820)
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. (1993) (788)
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. (1994) (689)
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. (1997) (659)
27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology (2013) (614)
Connections and Regulation of the Human Estrogen Receptor (2002) (591)
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. (1995) (525)
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. (1999) (504)
Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. (1987) (496)
Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol (1998) (491)
Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. (2006) (465)
The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators* (2001) (439)
Variant human breast tumor estrogen receptor with constitutive transcriptional activity. (1991) (439)
International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors (2006) (394)
Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. (1994) (372)
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor (1992) (372)
The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding (2000) (369)
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells (1994) (355)
Evaluation of a recombinant yeast cell estrogen screening assay. (1997) (353)
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. (1999) (352)
Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β (1999) (340)
The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. (1999) (339)
Common Estrogen Receptor Polymorphism Augments Effects of Hormone Replacement Therapy on E-Selectin but Not C-Reactive Protein (2002) (336)
The Molecular Pharmacology of SERMs (1999) (313)
Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. (2005) (301)
Hormone Therapy: Physiological Complexity Belies Therapeutic Simplicity (2004) (298)
Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. (1992) (287)
Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators (1994) (287)
The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor (1998) (261)
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. (2002) (246)
Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers (*) (1995) (235)
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells (2017) (222)
Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, and Androgen Receptor: Structure-Activity Studies (2000) (221)
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. (1994) (212)
Structural basis for an unexpected mode of SERM-mediated ER antagonism. (2005) (211)
Modulation of Estrogen Receptor-α Transcriptional Activity by the Coactivator PGC-1* (2000) (204)
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. (2008) (202)
Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance (2018) (197)
Mapping and Characterization of the Functional Domains Responsible for the Differential Activity of the A and B Isoforms of the Human Progesterone Receptor* (1997) (195)
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP (2005) (193)
Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. (2008) (191)
Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae (1999) (189)
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation (2011) (186)
The homeodomain protein HOXB13 regulates the cellular response to androgens. (2009) (182)
Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors α and β1. (1999) (179)
The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. (2010) (175)
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. (1998) (175)
Systematic identification of signaling pathways with potential to confer anticancer drug resistance (2014) (165)
Comparative analyses of mechanistic differences among antiestrogens. (1999) (163)
Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors (1996) (163)
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional acitivity (1994) (162)
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. (1999) (154)
Molecular biology of the vitamin D hormone. (1988) (151)
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. (1997) (150)
Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. (1990) (149)
Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression* (2006) (147)
Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. (1996) (141)
WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. (2010) (138)
Coactivator AIB1 links estrogen receptor transcriptional activity and stability. (2004) (137)
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. (2017) (136)
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. (2011) (136)
Disulfiram (DSF) acts as a copper ionophore to induce copper‐dependent oxidative stress and mediate anti‐tumor efficacy in inflammatory breast cancer (2015) (135)
Cholesterol and breast cancer pathophysiology (2014) (133)
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. (2008) (130)
Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer. (2015) (130)
Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. (2002) (130)
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. (1997) (124)
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. (2001) (124)
Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. (2015) (124)
High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae (1991) (123)
Copper signaling axis as a target for prostate cancer therapeutics. (2014) (123)
Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression. (1989) (121)
BRCA1 expression is not directly responsive to estrogen (1997) (121)
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. (2011) (119)
Bazedoxifene Exhibits Antiestrogenic Activity in Animal Models of Tamoxifen-Resistant Breast Cancer: Implications for Treatment of Advanced Disease (2013) (118)
Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy–Resistant Breast Cancer (2015) (117)
Comparative Analyses of Mechanistic Differences Among Antiestrogens1. (1999) (115)
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. (1992) (109)
Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. (2002) (108)
Structural organization and regulation of the chicken estrogen receptor. (1987) (107)
The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. (2011) (105)
Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. (2010) (105)
Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. (2007) (105)
Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. (2004) (104)
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. (1992) (101)
Potency of Combined Estrogenic Pesticides (1997) (101)
Problems for risk assessment of endocrine-active estrogenic compounds. (2002) (100)
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. (2000) (99)
Enhancement of Estrogen Receptor Transcriptional Activity by the Coactivator GRIP-1 Highlights the Role of Activation Function 2 in Determining Estrogen Receptor Pharmacology* (1998) (99)
The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis. (2013) (98)
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. (2005) (98)
The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. (2010) (97)
Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae (1989) (96)
Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. (1991) (94)
ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. (2016) (93)
Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). (1989) (93)
Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells. (1994) (92)
Estrogen-related receptor alpha as a therapeutic target in cancer. (2006) (92)
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. (2011) (91)
In situ distinction between steroid receptor binding and transactivation at a target gene (1991) (88)
A negative coregulator for the human ER. (2002) (87)
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. (1999) (86)
Obesity, cholesterol metabolism, and breast cancer pathogenesis. (2014) (85)
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. (2001) (83)
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells (2009) (81)
Androgen receptor-cofactor interactions as targets for new drug discovery. (2005) (80)
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors (2018) (79)
Structural Insights into Corepressor Recognition by Antagonist-bound Estrogen Receptors* (2007) (78)
Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. (2018) (78)
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. (2009) (78)
Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology (2013) (77)
Evaluation of ligand-dependent changes in AR structure using peptide probes. (2002) (76)
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. (2006) (75)
Androgens promote prostate cancer cell growth through induction of autophagy. (2013) (74)
Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. (2006) (74)
Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. (2005) (73)
CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. (2017) (72)
The molecular determinants of estrogen receptor pharmacology. (2004) (71)
Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor α as a Therapeutic Target in Cancer (2012) (71)
Inhibition of Aldehyde Dehydrogenase Expands Hematopoietic Stem Cells with Radioprotective Capacity (2010) (70)
Glucose metabolism as a target of histone deacetylase inhibitors. (2009) (70)
Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. (2006) (70)
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. (2017) (69)
The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor. (1988) (69)
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. (2012) (68)
Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. (2005) (68)
Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function (2018) (67)
Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. (2002) (67)
Human PXR forms a tryptophan zipper-mediated homodimer. (2006) (64)
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. (1997) (63)
An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy* (2010) (63)
16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. (1996) (63)
Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. (2015) (61)
Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. (2002) (60)
Cellular Mechanisms Which Distinguish between Hormone‐ and Antihormone‐Activated Estrogen Receptor (1995) (60)
ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. (2010) (58)
Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone (2014) (57)
The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. (2005) (57)
Nuclear Import/Export of hRPF1/Nedd4 Regulates the Ubiquitin- dependent Degradation of Its Nuclear Substrates* (2001) (56)
Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. (2012) (56)
Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. (2010) (56)
Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. (1993) (56)
Unraveling the human progesterone receptor signal transduction pathway Insights into antiprogestin action (1995) (55)
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer (2019) (55)
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. (2009) (54)
MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer (2016) (54)
Nuclear Hormone Receptors as Targets for New Drug Discovery (1993) (54)
Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. (2011) (53)
Definition of the Molecular Basis for Estrogen Receptor-Related Receptor-α-Cofactor Interactions (2007) (52)
Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. (1994) (51)
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. (2005) (50)
Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. (1992) (50)
Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. (2004) (49)
Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies. (1990) (49)
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation (2016) (48)
Cystine addiction of triple negative breast cancer associated with EMT augmented death signaling (2016) (45)
Characterization of Antiestrogenic Activity of the Chinese Herb, Prunella vulgaris, Using In Vitro and In Vivo (Mouse Xenograft) Models1 (2009) (45)
Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer (2021) (45)
Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. (2011) (44)
Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists (2009) (44)
Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration. (2004) (44)
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. (2007) (43)
Mining the complexities of the estrogen signaling pathways for novel therapeutics. (2003) (43)
The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins. (1999) (43)
Inhibition of 1,25‐Dihydroxyvitamin D3‐Dependent Transcription by Synthetic LXXLL Peptide Antagonists that Target the Activation Domains of the Vitamin D and Retinoid X Receptors (2002) (43)
27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. (2008) (42)
The Transcription Factor B-Myb Is Maintained in an Inhibited State in Target Cells through Its Interaction with the Nuclear Corepressors N-CoR and SMRT (2002) (41)
Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. (2013) (41)
The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways (2019) (41)
Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. (1991) (41)
Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation (2008) (40)
Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. (2009) (40)
Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways (2014) (40)
Capitalizing on the Complexities of Estrogen Receptor Pharmacology in the Quest for the Perfect SERM (2001) (39)
Minireview: Nuclear receptors, hematopoiesis, and stem cells. (2010) (39)
The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. (2007) (38)
Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. (2010) (37)
High level expression of a truncated chicken progesterone receptor in Escherichia coli. (1990) (36)
Selective Estrogen Receptor Modulators (SERMs): A First Step in the Development of Perfect Hormone Replacement Therapy Regimen (2000) (35)
Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. (2005) (35)
From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs) (2014) (35)
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression (2017) (35)
Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors. (1994) (35)
Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. (2003) (34)
Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. (1987) (33)
Development of peptide antagonists that target estrogen receptor–cofactor interactions (2000) (33)
HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer (2019) (32)
Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer (2017) (32)
Delineation of a FOXA1/ERα/AGR2 Regulatory Loop That Is Dysregulated in Endocrine Therapy–Resistant Breast Cancer (2014) (31)
The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways (2018) (31)
Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. (2007) (30)
The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. (1999) (29)
Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer* (2016) (29)
Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. (2019) (29)
The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer (2019) (29)
Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor (1995) (29)
Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. (1993) (28)
Multimodal Regulation of E2F1 Gene Expression by Progestins (2010) (28)
The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer (2014) (28)
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. (2017) (27)
Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. (1992) (26)
Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. (2009) (26)
Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen. (2000) (26)
Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. (2014) (25)
Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling (2017) (25)
On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. (2007) (24)
The Mechanism of Action of Steroid Hormones: A New Twist to an Old Tale (1993) (24)
Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy (2019) (24)
Estrogen-related receptor a as a therapeutic target in cancer (2006) (24)
Identification and Characterization of Novel Estrogen Receptor-β-Sparing Antiprogestins. (2002) (23)
Estrogen receptor mediated regulation of rat gonadotropin releasing hormone (GnRH) promoter activity in hypothalamic cells (1994) (21)
The Hsp 90 inhibitor , 17-AAG , prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells (2012) (21)
CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC (2017) (20)
Smoothelin-like 1 Protein Is a Bifunctional Regulator of the Progesterone Receptor during Pregnancy* (2011) (20)
Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies. (2019) (20)
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. (2015) (20)
The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. (2007) (20)
Validation of histone deacetylase 3 as a therapeutic target in castration‐resistant prostate cancer (2018) (20)
Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. (1993) (19)
Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment (1994) (19)
Synthetic LXXLL peptide antagonize 1,25‐dihydroxyvitamin D3‐dependent transcription (2003) (19)
Identification of novel steroid-response elements. (1992) (17)
Single-step purification of full-length human androgen receptor (2005) (17)
The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor (2020) (17)
Purification and characterization of recombinant human mineralocorticoid receptor (2009) (17)
DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin (2017) (16)
A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. (1992) (16)
Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer (2016) (15)
Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma. (2021) (14)
ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis. (2009) (14)
Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice* (2015) (14)
Definition of the molecular mechanism of action of tissue-selective oestrogen-receptor modulators. (1998) (13)
VITAMIN D3 RECEPTORS: MOLECULAR STRUCTURE OF THE PROTEIN AND ITS CHROMOSOMAL GENE (1988) (13)
Application of random peptide phage display to the study of nuclear hormone receptors. (2003) (13)
Development of Tissue-Selective Estrogen Receptor Modulators (1995) (13)
Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface (2016) (12)
27‐Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case‐Cohort Study in the Women's Health Initiative (2018) (11)
Creation of an active estrogen‐responsive element by a single base change in the flanking sequence of a cellular oncogene: A possible mechanism for hormonal carcinogenesis? (1993) (11)
Structure-Guided Synthesis of Tamoxifen Analogues with Improved Selectivity for the Orphan ERRγ. (2006) (11)
Coactivator AIB 1 links estrogen receptor transcriptional activity and stability (2004) (11)
4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors. (2014) (10)
Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets. (1989) (9)
Mechanism‐based discovery as an approach to identify the next generation of estrogen receptor modulators (2006) (9)
Fasting-Induced Hepatic Production of DHEA is Regulated by PGC-1α, ERRα and HNF4α (2009) (9)
ERRa-Regulated Lactate M etabolism Contributes to Resistance to Targeted Therapies in Breast Cancer (2016) (8)
Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. (2010) (8)
3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. (2012) (8)
Estrogen receptor signaling in the immune system. (2022) (7)
Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement. (2005) (7)
Estrogen-related receptor α as a therapeutic target (2006) (7)
Next-Generation Endocrine Therapies for Breast Cancer. (2021) (7)
Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. (2003) (7)
Reconstitution oftheVitamin D-Responsive Osteocalcin Transcription UnitinSaccharomyces cerevisiae (1989) (6)
Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. (2012) (5)
From bench to bedside and back again? (2004) (5)
Regulation of Bone Cell Function by Estrogens (2013) (5)
Saccharomyces cerevisiae As a Model System to Study Steroid Hormone Receptors (1997) (4)
The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. (2004) (4)
The Mechanism of Action of Steroid Hormone Receptors (2000) (4)
Direct effects of the selective CYP17 lyase (L) inhibitor, VT-464, on the androgen receptor (AR) and its oral activity in an F876L tumor mouse xenograft model. (2015) (4)
Saccharomyces cerevisiae Large Subunit of RNA Polymerase II in DNA Damage-Induced Degradation of the Rsp 5 Ubiquitin-Protein Ligase Mediates (1999) (3)
PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo. (2022) (3)
Targeting mutant estrogen receptors (2019) (3)
Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. (2018) (3)
Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer. (2021) (3)
Estrogen receptor-cofactor interactions as targets for novel drug discovery. (2001) (3)
Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106 (2015) (3)
Abstract P3-14-04: Effects of the dual selective CYP17 lyase inhibitor and androgen receptor (AR) antagonist, VT-464, on AR+ and ER+ tumor models in vitro and in vivo (2016) (2)
WNT11 expression is induced by ERR α and β -catenin and acts in an autocrine manner to increase cancer cell migration (2010) (2)
Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome (2019) (2)
The Vitamin D3 Receptor and Its Chromosomal Gene (1989) (2)
Advances in our understanding of ligand-activated nuclear receptors (1995) (2)
Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma (2022) (1)
Endocrine Society 2014 Laureate Awards (2014) (1)
Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product (2018) (1)
Eosinophilia in cancer and its regulation by sex hormones (2022) (1)
2 3 CYP 27 A 1 Loss Q 1 Dysregulates Cholesterol 4 Homeostasis in Prostate Cancer Q 2 5 (2017) (1)
Correction to: Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy (2019) (1)
1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
Abstract 1588: Effects of the selective CYP17-lyase and androgen receptor (AR) inhibitor, seviteronel, and the cyclin-dependent kinase (CDK) 4/6 inhibitor, G1T38, on tumor growth in an AR-V7+ castration-resistant prostate cancer (CRPC) xenograft model (2017) (1)
Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (2008) (1)
Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. (2002) (1)
Functional and Pharmacological Analysis of the A and B Forms of the Human Progesterone Receptor (1998) (1)
Combination mTORC1/2 and BCL- XL inhibition in endocrine and CDK4/6-resistant estrogen receptor-positive breast cancer. (2019) (1)
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer (2019) (1)
Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance (2018) (1)
CHAPTER 1 – Molecular Pharmacology of Estrogen and Progesterone Receptors (2000) (1)
Modulation of Aldehyde Dehydrogenase and Retinoid Signaling Induces the Expansion of Human Hematopoietic Stem Cells. (2005) (1)
Abstract 1805: Development of a selective androgen receptor degrader (SARD) for treatment of castration-resistant prostate cancer (2018) (1)
Assessment of activating estrogen receptor 1 (ESR1) mutations in gynecologic malignancies. (2018) (1)
Oxidized Lipids Activate Aryl Hydrocarbon Receptor (AhR) and Differentially Regulate Metabolic Pathways in Retinal Pigment Epithelial Cells (RPE) (2011) (1)
Molecular Pharmacology of Estrogen and Progesterone Receptors (2007) (1)
Abstract A82: The cholesterol metabolite, 27-hydroxycholesterol, promotes breast cancer metastasis (2015) (1)
Analysis of the Mechanism of Action of RPF1: Potentiator of Progesterone Receptor and p53-dependent Transcriptional Activity (1999) (1)
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors (2018) (0)
The Impact of 27-Hydroxycholesterol, a Macrophage-Synthesized Estrogen Receptor Agonist, on Breast Cancer Pathophysiology (2010) (0)
The Molecular Mechanisms Underlying the Pro-Inflammatory Actions of Thiazolidinediones ( TZDs ) in Human Macrophages (2007) (0)
Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer (2022) (0)
Molecular Pathways Molecular Pathways : The Metabolic Regulator Estrogen-Related Receptor a as a Therapeutic Target in Cancer (2012) (0)
Quantifying Nitrogen Sources and Cycling Along the Upper Rio Grande (2005) (0)
MON-218 Inflammatory Role of Sex Steroids in Hidradenitis Suppurativa: An Androgenic Phenotype (2019) (0)
Expression Profiling of Nuclear Receptors in Human Retinal Pigment Epithelial Cells: Relevance to Age-Related Macular Degeneration (2010) (0)
Progesterone Receptor Transcriptional Activity of the Human 8-Bromo-Cyclic AMP-Dependent Key Regulators of Both Ligand-and The Nuclear Corepressors NCoR and SMRT Are (1998) (0)
Metabolic regulation of CD4+ T cells by Estrogen Related Receptor-{alpha} modulates autoimmune and allergic disease (2012) (0)
Meeting Review The Jensen Symposium: AT ribute to aP ioneer in the Field of Nuclear Receptor Biology (2004) (0)
Meet the New Hormones and Cancer Editorial Team: Donald P. McDonnell, Associate Editor (2015) (0)
The commercialism of academic research (2008) (0)
Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells (2022) (0)
Liver X Receptor signaling pathways and age-related macular degeneration (2014) (0)
The Role of Estrogen Related Receptor in Modulating Estrogen Receptor Mediated Transcription in Breast Cancer Cells (2005) (0)
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE (2007) (0)
DEFINITION OF THE FUNCTIONAL DOMAINS OF THE VITAMIN D3 RECEPTOR (1988) (0)
Regulation of the Chicken Estrogen Receptor (2008) (0)
To the Editorial Board of BONE (2002) (0)
EXPRESSION OF FUNCTIONAL VITAMIN D3 RECEPTOR IN E. COLI (1991) (0)
80 Determination of an oxidative stress gene signature in inflammatory breast cancer patient tumors and development of a novel redox modulatory strategy in overcoming chemotherapy resistance and mediating anti-tumor efficacy (2014) (0)
Estrogen-related receptor a as cancer (2007) (0)
Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP (2005) (0)
Definition of the Cellular Mechanisms which Distinguish Between Estrogen Receptor Agonists and Antagonists (2001) (0)
Oncogenes and Tumor Suppressors Delineation of a FOXA 1 / ER a / AGR 2 Regulatory Loop That Is Dysregulated in Endocrine Therapy – Resistant Breast Cancer (2014) (0)
in Vitro Increased CXCR4-Dependent Migration of Prostate Cancer Cells Induction of Krüppel-Like Factor 5 Expression by Androgens Results in (2009) (0)
Applied nuclear receptor research in the drug discovery process (1994) (0)
Estrogen related receptor-{alpha} is a global metabolic and fate determinant for T lymphocytes (2010) (0)
Award Number: DAMD17-03-1-0674 TITLE: Structural Determination of Certain Novel ER Complexes (2005) (0)
Effects of selective androgen receptor modulators in experimental models of SBMA (2009) (0)
Abstract A44: Pharmacologic targeting of estrogen receptor in melanoma to enhance antitumor immunity (2020) (0)
Abstract A51: Impact of CaMKK2 inhibition in tumor-associated myeloid cells on CD8+ cytotoxic T-cell recruitment into mammary tumors (2020) (0)
Abstract B02: Estrogens regulate tumor associated tissue eosinophilia to promote tumor growth (2022) (0)
Expression vector that produce steroid receptor, steroid receptor chimera, screening assay for steroid receptor and clinical assay using synthesized receptor and receptor vector (1991) (0)
Abstract 4542: Dose-dependent effects of progestins on progesterone receptor activity and target gene expression: less is more (2011) (0)
SERMs (Selective Estrogen Receptor Modulators) (2003) (0)
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells (2017) (0)
Abstract B06: 17β-estradiol negatively regulates natural killer cells and promotes breast cancer metastasis (2022) (0)
The impact of the Women's Health Initiative on the search for improved treatments for the conditions associated with long-term oestrogen deprivation (2003) (0)
CYP27A1/27HC/SREBP2 axis is a novel therapeutic target in prostate cancer (2016) (0)
Abstract PR11: Dysregulation of cholesterol homeostasis through loss of CYP27A1 in prostate cancer; Implications for early detection and prevention of over-treatment (2015) (0)
Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638 (2004) (0)
Modulation of aldehyde dehydrogenase activitiy and retinoid signaling induces hematopoietic stem cell self renewal (2006) (0)
A method for prophylaxis or treatment of estrogen-dependent diseases (1998) (0)
Abstract B05: Assessing estrogen receptor signaling and function in dendritic cells within the tumor microenvironment (2022) (0)
Abstract 4570: Role of ERRalpha in ovarian cancer (2014) (0)
Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer (2014) (0)
A new chemotype of chemically tractable nonsteroidal estrogens based on a thieno[2,3-d]pyrimidine core (2022) (0)
Metabolic regulation of CD4+ T cells by Estrogen Related Receptor-α modulates autoimmune and allergic disease (123.48) (2012) (0)
Abstract A96: The role of the proto-oncogene AGR2 in endocrine resistant breast cancer. (2013) (0)
Human Progesterone A-Form as a Target for New Drug Discovery in Human Breast Cancer (2001) (0)
Estrogen-related receptor alpha and Rplp1-dependent translation coordinately regulate starvation response and decrease NASH progression (2021) (0)
Cancer Pathophysiology 27-Hydroxycholesterol Links Hypercholesterolemia and Breast (2013) (0)
11PImpact of the sterol 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol on tumor-pathological features, prognosis and response to statin treatment in breast cancer (2017) (0)
Ef fi cacy of SERD / SERM Hybrid-CDK 4 / 6 Inhibitor Combinations in Models of Endocrine Therapy – Resistant Breast Cancer (2015) (0)
Abstract IA30: Targeting hormone receptors for degradation: Nuclear receptor downregulation as a therapeutic approach in cancer (2017) (0)
The Retinoid X Receptor Regulates Human Hematopoietic Stem Cell Fate. (2006) (0)
Oxidant Activation of the Transcription Factor Aryl Hydrocarbon Receptor Effects Mitochondrial Function in Retinal Pigment Epithelial Cells (2010) (0)
Abstract P3-07-14: Targeting ERR-α regulated lactate metabolism eliminates drug-resistant breast cancer cells (2017) (0)
CaMKK2-can: A dance between CaMKK2 and Rb in high-grade serous ovarian cancer patients with therapeutic potential (2019) (0)
Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis (2023) (0)
Abstract PR3: The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis (2013) (0)
Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter (2005) (0)
Defining the molecular pharmacology of disease relevant estrogen receptor mutations for effective therapeutic targeting in breast cancer (2019) (0)
ANALYSIS OF THE LIGAND-BINDING DOMAIN OF THE HUMAN PROGESTERONE-RECEPTOR (1992) (0)
Corepressor Associated Peptides (CAPs): Tools to Elucidate the Role of Corepressors as Regulators of Progesterone Receptor Transcriptional Activity (2002) (0)
Estrogen related receptor-α is a global metabolic and fate determinant for T lymphocytes (139.8) (2010) (0)
Abstract A50: Cyclin D1 isoforms selectively manipulate AR signaling to promote metastatic phenotypes in early and castration-resistant prostate cancer. (2012) (0)
Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling (2022) (0)
Advances in Brief Inhibition of Estrogen Receptor Action by a Naturally Occurring Variant in Human Breast Tumors 1 (2006) (0)
Research Resource Articles—A New Feature for Molecular Endocrinology (2006) (0)
Constitutive Transcriptional Activity Variant Human Breast Tumor Estrogen Receptor with Updated Version (2006) (0)
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST (2007) (0)
ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1. (2023) (0)
The Impact of 27-Hydroxycholesterol, a Macrophage-Produced Estrogen Receptor and Liver X Receptor Agonist, on Breast Cancer Pathophysiology (2011) (0)
SGC-CAMKK2-1: A Chemical Probe for CAMKK2 (2022) (0)
Receptor Connections and Regulation of the Human Estrogen (2009) (0)
Clinical Efficacy and Whole Exome Sequencing of Liquid Biopsies in a Phase IB/II study of Bazedoxifene and Palbociclib in Hormone Receptor-Positive Breast Cancer. (2022) (0)
Method for prevention or treatment of disorders and diseases dependent on estrogen (1998) (0)
In Vitro Methods for Characterizing Chemical Interactions with Steroid Hormone Receptors (2001) (0)
FUNCTIONAL DISSECTION OF THE VITAMIN D RECEPTOR TRANSDUCTION PATHWAY (1991) (0)
Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells. (2021) (0)
1 AN INTERDOMAIN INTERACTION OF THE ANDROGEN RECEPTOR IS REQUIRED FOR ITS AGGREGATION AND TOXICITY IN SPINAL AND BULBAR MUSCULAR ATROPHY (2010) (0)
Does the loss of RAD52 in PC contribute to resistance to antiandrogen therapy (2017) (0)
Abstract 2820: Effects of a CDK 4/6 inhibitor, G1T38, in androgen receptor sensitive and resistant models of castrate resistant prostate cancer (2016) (0)
Constitutive Somatostatin Receptor Activity Determines Tonic Pituitary Cell Response (2009) (0)

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