Donald. R. Stanski
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Pharmacology
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Donald. R. Stanskiphilosophy Degrees
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Medical Philosophy
Donald. R. Stanski's Degrees
- Masters Medicine University of California, San Francisco
- PhD Pharmacology University of California, San Francisco
Why Is Donald. R. Stanski Influential?
(Suggest an Edit or Addition)Donald. R. Stanski's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine (1979) (706)
- Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. (1980) (679)
- The Pharmacokinetics of the New Short‐acting Opioid Remifentanil (GI87084B) in Healthy Adult Male Volunteers (1993) (573)
- EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. (1985) (526)
- Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. (1987) (485)
- Comparative pharmacology of the ketamine isomers. Studies in volunteers. (1985) (362)
- Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil. (1991) (324)
- Absorption characteristics of transdermally administered fentanyl. (1989) (316)
- A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect (1997) (285)
- Population pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients. (1987) (258)
- Absorption and bioavailability of oral transmucosal fentanyl citrate. (1991) (237)
- Linearity of Pharmacokinetics and Model Estimation of Sufentanil (1995) (180)
- Kinetics of intravenous and intramuscular morphine (1978) (166)
- The Effect of Increasing Age on Thiopental Disposition and Anesthetic Requirement (1985) (165)
- Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development (1992) (156)
- Alfentanil--a kinetically predictable narcotic analgesic. (1982) (154)
- The future of drug development: advancing clinical trial design (2009) (148)
- Characterization and validation of a pharmacokinetic model for controlled-release oxycodone. (2003) (147)
- Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited. (1990) (147)
- Thiopental pharmacodynamics. II. Quantitation of clinical and electroencephalographic depth of anesthesia. (1992) (146)
- Population pharmacodynamic model for ketorolac analgesia (1996) (132)
- Pharmacokinetics and Pharmacodynamics of d‐Tubocurarine in Infants, Children, and Adults (1982) (126)
- Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam (1990) (126)
- Increased Sensitivity to Etomidate in the Elderly: Initial Distribution versus Altered Brain Response (1986) (125)
- Hemodynamic Response to Induction and Intubation: Propofol/Fentanyl Interaction (1994) (124)
- Comparison of a Computer‐assisted Infusion Versus Intermittent Bolus Administration of Alfentanil as a Supplement to Nitrous Oxide for Lower Abdominal Surgery (1988) (116)
- The Role of Metabolism and Protein Binding in Thiopental Anesthesia (1983) (107)
- Pharmacokinetics of Methohexital and Thiopental in Surgical Patients (1983) (106)
- Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man (1987) (105)
- Computer Simulation of the Effects of Alterations in Blood Flows and Body Composition on Thiopental Pharmacokinetics in Humans (1997) (98)
- Pharmacodynamics of Orally Administered Sustained- release Hydromorphone in Humans (2001) (96)
- Kinetics of intravenous and intramuscular morphine. (1979) (93)
- Input Characteristics and Bioavailability after Administration of Immediate and a New Extended-release Formulation of Hydromorphone in Healthy Volunteers (2002) (90)
- Thiopental pharmacodynamics. I. Defining the pseudo-steady-state serum concentration-EEG effect relationship. (1992) (88)
- Dexmedetomidine Decreases Thiopental Dose Requirement and Alters Distribution Pharmacokinetics (1994) (87)
- Pharmacokinetics and Pharmacodynamics of d-Tubocurarine during Nitrous Oxide–Narcotic and Halothane Anesthesia in Man (1979) (86)
- An evaluation of the accuracy of pharmacokinetic data for the computer assisted infusion of alfentanil. (1985) (81)
- Evaluating the Accuracy of Using Population Pharmacokinetic Data to Predict Plasma Concentrations of Alfentanil (1988) (79)
- Pharmacokinetics, pharmacodynamics, and relative pharmacokinetic/pharmacodynamic profiles of zaleplon and zolpidem. (2000) (75)
- Comparative tissue concentration profiles of fentanyl and alfentanil in humans predicted from tissue/blood partition data obtained in rats. (1990) (72)
- Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat. (1997) (69)
- Pharmacokinetics of high-dose thiopental used in cerebral resuscitation. (1980) (69)
- Quantitation of Depth of Thiopental Anesthesia in the Rat (1996) (65)
- Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model (2018) (65)
- Pharmacokinetics of Edrophonium and Neostigmine When Antagonizing d‐Tubocurarine Neuromuscular Blockade in Man (1981) (63)
- Pharmacokinetic‐pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil (1994) (62)
- Understanding pharmacokinetics and pharmacodynamics through computer stimulation: I. The comparative clinical profiles of fentanyl and alfentanil. (1990) (62)
- Improving the clinical utility of anesthetic drug pharmacokinetics. (1992) (59)
- Lumbar Epidural Morphine in Humans and Supraspinal Analgesia to Experimental Heat Pain (2000) (57)
- Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development (1992) (56)
- Thiopental Uncouples Hippocampal and Cortical Synchronized Electroencephalograpbic Activity (1996) (56)
- Pyridostigmine kinetics with and without renal function (1980) (56)
- Efficacy and Safety of Single Doses of Intramuscular Ketorolac Tromethamine Compared with Meperidine for Postoperative Pain (1990) (56)
- Kinetics of high‐dose intravenous morphine in cardiac surgery patients (1976) (56)
- Pharmacodynamic modeling of anesthetic EEG drug effects. (1992) (55)
- Electroencephalographic effects of benzodiazepines. I. Choosing an electroencephalographic parameter to measure the effect of midazolam on the central nervous system (1990) (54)
- Assay methods for fentanyl in serum: gas-liquid chromatography versus radioimmunoassay. (1987) (50)
- Pharmacodynamic modeling of thiopental anesthesia (1984) (49)
- Quantifying anesthetic drug interaction. Implications for drug dosing. (1995) (48)
- Decreased protein binding and thiopental kinetics (1982) (47)
- CURARE NEUROMUSCULAR BLOCKADE DURING HYPOTHERMIA IN MAN (1979) (44)
- Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs (2010) (42)
- Chronic alcohol intake does not change thiopental anesthetic requirement, pharmacokinetics, or pharmacodynamics. (1990) (41)
- Defining depth of anesthesia. (2008) (40)
- Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches (2011) (40)
- Comparative absorption kinetics of intramuscular midazolam and diazepam (1996) (38)
- From piecewise to full physiologic pharmacokinetic modeling: Applied to thiopental disposition in the rat (1994) (34)
- Pharmacokinetics of edrophonium in anephric and renal transplant patients. (1981) (34)
- Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam (1995) (33)
- Effects of cardiac surgery with cardiopulmonary bypass on lidocaine disposition (1984) (31)
- Effects of Thiopental on Regional Blood Flows in the Rat (1996) (31)
- High-performance liquid chromatographic method for determining thiopental concentrations in twelve rat tissues: application to physiologic modeling of disposition of barbiturate. (1989) (31)
- Plasma Concentration Clamping in the Rat Using a Computer-Controlled Infusion Pump (1992) (30)
- Morphine pharmacokinetics: GLC assay versus radioimmunoassay. (1982) (30)
- Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single-tissue models (1994) (30)
- Renal Function and the Pharmacokinetics of Neostigmine in Anesthetized Man (1979) (29)
- Time‐dependent Increase in Sensitivity to d‐Tubocurarine during Enflurane Anesthesia in Man (1980) (29)
- High-performance liquid chromatographic assay of propofol in human and rat plasma and fourteen rat tissues using electrochemical detection. (1996) (29)
- Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling (2014) (28)
- Simultaneous determination of fentanyl and alfentanil in rat tissues by capillary column gas chromatography. (1988) (27)
- Pharmacokinetics and anesthetic potency of a thiopental isomer. (1983) (26)
- Drug disposition in anesthesia (1982) (25)
- Inadequate anaesthesia in lethal injection for execution (2005) (24)
- Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model (1993) (24)
- Enriched analgesic efficacy studies: an assessment by clinical trial simulation. (2006) (23)
- Pharmacokinetics and Pharmacodynamics of d‐Tubocurarine during Nitrous Oxide–Narcotic and Halothane Anesthesia in Man (1979) (23)
- Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet. (2017) (22)
- Pharmacokinetics and Pharmacodynamics of Intravenously Administered Anesthetic Drugs: Concepts and Lessons for Drug Development (2008) (22)
- Factors Affecting the Measurement of Lidocaine Protein Binding by Equilibrium Dialysis in Human Serum (1985) (21)
- A semiparametric approach to physiological flow models (1989) (21)
- Pharmacokinetics and Dynamics of d‐Tubocurarine during Hypothermia in Humans (1981) (21)
- Similarity between effects of pancuronium and atropine on plasma norepinephrine levels in man. (1979) (20)
- Monitoring the Depth of Anesthesia (2010) (20)
- DECREASED FENTANYL/ALFENTANIL DOSE REQUIREMENTS WITH INCREASING AGE: A PHARMACODYNAMIC BASIS (1985) (19)
- Getting the Dose Right: Report From the Tenth European Federation of Pharmaceutical Sciences (EUFEPS) Conference on Optimizing Drug Development (2005) (18)
- A PC-based graphical simulator for physiological pharmacokinetic models. (1995) (17)
- Innovative approaches to clinical development and trial design. (2011) (15)
- DEFINING THIOPENTAL'S STEADVT STATE PIASMA CONCENTRATION - EEG EFFECT REIATIONSHIP (1987) (14)
- ESTIMATION OF BRAIN SENSITIVITY TO THIOPENTAL WITH THE EEG (1982) (13)
- Current issues relating to drug safety especially with regard to the use of biomarkers: a meeting report and progress update. (2007) (13)
- PHARMACOMETRICS Pharmacodynamic Modeling of Thiopental Anesthesia (1984) (13)
- The electroencephalogram (EEG)and clinical measures of opioid potency: defining the EEG-clinical potency relationship (‘fingerprint’) with application to remifentanil (2001) (13)
- Translational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated Phosphorylation (2014) (12)
- THE PHARMACOKINETICS AND PHARMACODYNAMICS OF G187084B (1992) (11)
- CAN THE EEG BE USED TO MONITOR ANESTHETIC DEPTH FOR ALFENTANIL WITH N2O (1987) (11)
- TIME DEPENDENT INCREASE IN SENSITIVITY TO dTC DURING ENFLURANE ANESTHESIA (1979) (11)
- COMPARATIVE PHARMACODYNAMICS OF MIDAZOLAM AND DIAZEPAM (1988) (10)
- Pharmacokinetics and dynamics of muscle relaxants. (1979) (9)
- COMPARATIVE PHARMACOKINETICS OF METHOHEXITAL AND THIOPENTAL (1982) (9)
- Pharmacokinetics of alfentanil administered at a variable rate during three types of surgery. (1993) (8)
- Determination of alfentanil in serum by radioimmunoassay or capillary column gas-liquid chromatography. A comparison of the assays. (1989) (8)
- Workshop on safe feedback control of anesthetic drug delivery. Schloss Reinhartshausen, Germany. June 29, 1998. (1999) (8)
- Pharmacometric Modeling of Naloxegol Efficacy and Safety: Impact on Dose and Label (2017) (8)
- The clinical pharmacology of alfentanil. (1987) (8)
- New Intravenous Anesthetics (1991) (7)
- PHARMACOLOGICAL QUANTITATION OF MIDAZOLAM'S CNS DRUG EFFECT IN HYPNOTIC DOSES (1987) (7)
- BIOAVAILABILITY AND ABSORPTION OF TRANSDERMAL FENTANYL (1988) (7)
- Estimating the rate of thiopental blood-brain equilibration using pseudo steady state serum concentrations (1990) (7)
- Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics (2018) (7)
- Exposure‐Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction (2017) (6)
- APPLYING ALFENTANIL POKHATION PHARMACOKINETICS TO PREDICT PERIOPERATIVE PLASMA CONCENTRATIONS (1986) (6)
- Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach (2017) (6)
- Plasma and cerebrospinal fluid concentrations of chlordiazepoxide and its metabolites in surgical patients. (1977) (6)
- Quantitation of thiopental anesthetic depth with clinical stimuli. (1990) (5)
- HEMODYNAMIC EFFECTS OF HIGH DOSE THIOPENTAL ANESTHESIA IN HUMANS (1982) (5)
- D-TubocurarinePharmacodynamics and Kinetics in Children (1979) (5)
- Communicating With the FDA: The “Third Rail” of a New Model for Drug Development (2008) (4)
- Narcotic pharmacokinetics and dynamics: the basis of infusion applications. (1987) (4)
- PHARMACOKINETIC AND PHARMACODYNAMIC MODEL OP ETOMIDATE'S EBG EFFECTS (1984) (4)
- Use of the epidural blood patch in the treatment of chronic headaches. (1986) (4)
- Factors Affecting the Measurement of Lidocaine Protein Binding by Equilibrium Dialysis (1984) (4)
- THE ROLE OF THE FETAL LIVER IN THE DISTRIBUTION OF THIOPENTAL FROM MOTHER TO FETUS (1982) (4)
- Time-Dependent Increase in Sensitivity to d-Tubocurarine during Enflurane Anesthesia in Man (1981) (4)
- Estimating the contribution of everolimus to immunosuppressive efficacy when combined with tacrolimus in liver transplantation: A model‐based approach (2015) (4)
- Atypical cholinesterase in a patient with myasthenia gravis. (1977) (3)
- Pharmacokinetics and Pharmacodynamics of d-Tubocurarine in Infants, Children, and Adults (1983) (3)
- Partition Coefficient vs. Dissociation Rate Constant as Determinant of Duration of Neuromuscular Blockade (1981) (3)
- PHARMACOKINETIC MODEL FOR A NEW ORAL CONTROLLED RELEASE FORMULATION OF OXYCODONE (1994) (3)
- DEPTH OF ANESTHESIA MONITORING TECHNIQUES: AN OVERVIEW (1999) (3)
- The Titration Paradox Turns Pharmacology Upside Down (2021) (3)
- ZERO ORDER PHARMACOKINETICS OF HIGH DOSE THIOPENTAL (1979) (3)
- Factors influencing blood concentrations of chlordiazepoxide: A use of multiple regression analysis (1977) (3)
- PHARMACOKINETIC ANALYSIS OF FENTANYL ADMINISTERED BY A COMPUTER CONTROLLED INFUSION PUMP (1987) (3)
- The pharmacokinetics of intravenous fluids. (1997) (3)
- A semi-parametric approach to physiological flow models (1990) (3)
- Integrating dose estimation into a decision‐making framework for model‐based drug development (2018) (3)
- No effect of age on the dose requirement of thiopental in the rat (1997) (3)
- KINETICS OF HIGH-DOSE INTRAVENOUS MORPHINE IN CARDIAC SURGERY PATIENTS (1977) (2)
- Computer-assisted infusions of drugs. (1986) (2)
- USING PHARMACODYNAMIC MODELLING OF THE ELECTROENCEPHALOGRAM (EEG) TO UNDERSTAND ANESTHETIC DRUG CLINICAL PHARMACOLOGY (1990) (2)
- DOSE POTENCY COMPARISON OF THIOPENTAL AND ETOMIDATE (1985) (2)
- DEXMEDETOMIDINE ALTERS THIOPENTAL DOSE REQUIREMENT AND DISTRIBUTION PHARMACOKINETICS (1991) (2)
- Pharmacokinetics and pharmacodynamics for the clinician (1991) (2)
- COMPARATIVE PHARMACODYNAMICS OF FENTANYL AND ALFENTANIL USING THE EEG (1984) (2)
- A391 USE OF EEG AS A MEASURE OF THIOPENTAL ANESTHETIC DEPTH (1990) (2)
- Lessons learned in drug development from anesthesia. (2005) (2)
- Radioimmunoassay and related procedures in medicine–1982. Proceedings series; International Atomic Energy Agency. 1983. 823 pp. 15 × 24 cm (1983) (2)
- The role of pharmacokinetics in anaesthesia: application to intravenous infusions. (1987) (2)
- Antagonism of Pancuronium and Its Metabolites by Neostigmine in Cats (1979) (2)
- Plasma and cerebrospinal fluid concentrations of chlordiazepoxide and its metabolites in surgical patients [proceedings]. (1977) (1)
- Pharmacokinetic modelling of thiopental. (1981) (1)
- Pharmacodynamic Modeling of Thiopental Depth of Anesthesia (1991) (1)
- THE EFFECT OF INCREASING AGE ON ETOMIDATE PHARMACOKINETICS (1984) (1)
- Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19 (2022) (1)
- PHARMACOKINETICS OF EDROPHONIUM IN PATIENTS WITHOUT RENAL FUNCTION (1980) (1)
- Def ining Depth of Anesthesia (2008) (1)
- PHARMACOK I NETICS OF EDROPHONIUM AND NEOSTIGMI NE WHEN ANTAGONIZING d‐TUBO CURARINE NEUROMUSCULAR BLOCKADE IN MAN (1980) (1)
- ALFENTANIL PHARMACOKINETICS DURING A VARIABLE-RATE INFUSION IN SURGICAL PATIENTS (1986) (1)
- The Role of Pharmacokinetics in Anesthesia (1981) (1)
- THE EFFECT OF CARDIOPULMONARY BYPASS ON LIDOCAINE DISPOSITION (1982) (1)
- Antagonism of pancuronium and its metabolites by neostigmine in cats. (1979) (1)
- Dynamic predictions of patient survival using longitudinal tumor size in non-small cell lung cancer: Approach towards personalized medicine. (2017) (1)
- DOES ACUTE TOLERANCE TO THIOPENTAL EXIST? (1982) (1)
- HIGH-DOSE THIOPENTAL REQUIREMENT TO MAINTAIN A NEARLY ISOELECTRIC EEG DURING HYPOTHERMIC CARDIOPULMONARY BYPASS (1988) (1)
- Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs (1993) (0)
- REVIEWS: Radioimmunoassay and Related Procedures in Medicine-1982. (1983) (0)
- A computer controlled infusion pump rapidly achieves and maintains stable plasma thiopental concentrations and EEG-effects in the rat (1990) (0)
- Pitfalls in Deriving Pharmacokinetic Variables. III (1982) (0)
- A CLINICAL COMPARISON OF BOLUS VERSUS CONTINUOUS INFUSION OF FENTANYL FOR CORONARY ARTERY BYPASS SURGERY (1986) (0)
- Comment on the report "limitations of model-based dose selection for indacaterol in patients with chronic obstructive pulmonary disease". (2012) (0)
- A MODEL OF ANESTHETIC DOSE REQUIREMENT: PHARMACOKINETIC AND PHARMACODYNAMIC DETERMINANTS (1986) (0)
- A CHRONICALLY INSTRUMENTED RAT MODEL FOR COMBINED PHARMACOKINETIC AND CNS PHARMACODYNAMIC ASSESSMENT OF ANESTHETICS (1987) (0)
- Erratum to: Comparative physiological pharmacokinetics of fenatyl and alfenatil in rats and humans based on parametric single-tissue models (2006) (0)
- Lecture Objectives: To introduce clinicians to the essential role of the biophase in understanding the relationship between concentration and response, and thus the relationship between drug dose and drug response. (1999) (0)
- Conference Summary (2019) (0)
- PLASMA CONCENTRATIONS OF ALFENTANIL REQUIRED TO SUPPLEMENT N2O IN SURGICAL PATIENTS (1985) (0)
- THE POPULATION FfffiFMAOOKINETICS OF ALFENIANIL: QUANITTATING THE AVERAGE DOSE-SERUM CXWCENIRATION RELATIONSHIP (1986) (0)
- The influence of thiopental-induced alterations in regional blood flows on thiopental distribution in the rat (1994) (0)
- The Biophase Concept (1999) (0)
- Survival prediction using time-evolving tumor load: An approach to rationally design treatment sequencing, staging, and dosing strategies for oncology combinations. (2017) (0)
- Gerry???s Real World Guide to Pharmacokinetics and Other Things. (2006) (0)
- The Population Pharmacokinetics Of Alfentanil: Quantitating The Average Dose-serum Conceniration Relationship (1986) (0)
- Questions Regarding a Time-dependent Increase in Sensitivity to d -Tubocurarine during Enflurane Anesthesia (1981) (0)
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