Donna Huryn
American chemist
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Chemistry
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(Suggest an Edit or Addition)According to Wikipedia, Donna M. Huryn is an American medicinal and organic chemist. She received her B.A. from Cornell University, and Ph.D. in organic chemistry from the University of Pennsylvania. She is on the faculty at the University of Pittsburgh’s school of pharmacy, holds an adjunct appointment in the department of chemistry at the University of Pennsylvania, is the principal investigator of the University of Pittsburgh Chemical Diversity Center, and was a visiting fellow in the summer of 2017 at the University of Bologna. She is a fellow of the American Chemical Society, recipient of the ACS Philadelphia Local Section Award, has held a number of elected positions within the American Chemical Society at both the local and national levels, and is 2015 Chair of the Division of Organic Chemistry. Huryn also formed, along with a number of other scientists, the Empowering Women in Organic Chemistry Conferences in 2019. The goal was to empower and bring the research and career of all marginalized individuals in chemistry-related fields to the forefront of the scientific community. Huryn noticed how there was not enough women pursuing and maintaining a career in organic chemistry, and thus founded this organization. The Empowering Women in Organic Chemistry Conferences allowed for women leaders to present their scientific findings and hear the stories of how eminent women in the field of organic chemistry overcame the challenges they faced being female. She is associate editor of ACS Medicinal Chemistry Letters. She in also an editor of the journal Organic Reactions and co-authored the textbook Medicinal Chemistry and the article "Medicinal Chemistry: Where Are All the Women?" which appeared in the ACS Medicinal Chemistry Letters Journal. Huryn’s research focuses on the design and synthesis of small molecules probes and drugs to treat cancer, neurodegenerative and infectious diseases.
Donna Huryn's Published Works
Published Works
- AIDS-driven nucleoside chemistry. (1992) (431)
- Carboxylic Acid (Bio)Isosteres in Drug Design (2013) (308)
- 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition (2016) (269)
- Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. (2012) (153)
- Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease (2009) (148)
- Structure Property Relationships of Carboxylic Acid Isosteres (2016) (138)
- Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. (2009) (122)
- A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells (2010) (111)
- Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery Candidates (2003) (108)
- Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. (2008) (101)
- Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. (2009) (96)
- HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. (2007) (92)
- Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. (2008) (81)
- Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish (2010) (77)
- Ferroptosis as a Novel Therapeutic Target for Friedreich’s Ataxia (2019) (75)
- Experimental design on single-time-point high-throughput microsomal stability assay. (2004) (70)
- Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators (2011) (68)
- Microtubule-stabilising drugs for therapy of Alzheimer’s disease and other neurodegenerative disorders with axonal transport impairments (2005) (66)
- Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography-mass spectrometry. (2003) (64)
- Synthesis and anti-HIV activity of isonucleosides. (1992) (52)
- Synthesis of iso-ddA, member of a novel class of anti-HIV agents (1989) (51)
- Temperature‐dependent growth and life cycle of Deleatidium (Ephemeroptera: Leptophlebiidae) in two high‐country streams in New Zealand (1996) (51)
- p97: An Emerging Target for Cancer, Neurodegenerative Diseases and Viral Infections. (2020) (50)
- Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. (2015) (47)
- Screening of 5-HT1A receptor antagonists using molecularly imprinted polymers. (2007) (44)
- Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. (2011) (40)
- Contributions of academic laboratories to the discovery and development of chemical biology tools. (2013) (39)
- Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L (2008) (34)
- The identification and optimization of orally efficacious, small molecule VLA-4 antagonists. (2004) (33)
- Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. (2011) (30)
- Synthesis of E-selectin inhibitors: Use of an aryl-cyclohexyl ether as a disaccharide scaffold (1996) (29)
- Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. (2016) (28)
- Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins. (2012) (28)
- Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury. (2016) (27)
- HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines. (2015) (27)
- Drug discovery in an academic setting: playing to the strengths. (2013) (25)
- Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells. (2016) (25)
- Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. (2016) (24)
- Natural product chemistry and anticancer drug discovery (2014) (23)
- Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. (2006) (22)
- Medicinal Chemistry: Where Are All the Women? (2017) (22)
- 1.01 Carbanions of Alkali and Alkaline-Earth Cations: (II) Selectivity of Carbonyl Addition Reactions (1991) (21)
- 4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands. (2005) (21)
- Discovery of a novel series of Notch-sparing gamma-secretase inhibitors. (2008) (21)
- AIDS‐Driven Nucleoside Chemistry (1993) (21)
- Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors. (2005) (20)
- Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. (2008) (19)
- Chapter 26 The Molecular Libraries Screening Center Network (MLSCN): Identifying Chemical Probes of Biological Systems (2007) (19)
- Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain (2008) (18)
- High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy (2020) (17)
- Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. (2007) (17)
- Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. (2005) (16)
- A Focused Library of Tetrahydropyrimidinone Amides via a Tandem Biginelli-Ugi Multi-Component Process (2006) (16)
- Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. (2007) (16)
- Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. (2008) (15)
- Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. (2008) (15)
- Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97 (2018) (15)
- Integrity profiling of high throughput screening hits using LC-MS and related techniques. (2005) (14)
- 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. (2014) (14)
- Affinity Capture of p97 with Small-Molecule Ligand Bait Reveals a 3.6 Å Double-Hexamer Cryoelectron Microscopy Structure. (2021) (12)
- Do Zebrafish Obey Lipinski Rules? (2019) (12)
- Synthesis and Biological Activity of a Focused Library of Mitogen‐activated Protein Kinase Phosphatase Inhibitors (2007) (11)
- Total synthesis of (+)-mikrolin (1987) (11)
- PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies (2020) (11)
- Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors. (2009) (11)
- Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines (2017) (11)
- Total synthesis of (−)-gilmicolin (1985) (10)
- Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists. (2004) (10)
- A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD). (2009) (9)
- Synthesis of the 6′-Fluoro Derivatives of Carbocyclic 2′,3′-Dideoxy-3′-oxa-adenosine (1991) (9)
- Synthesis of 3′-C-Substituted-2′,3′-Dideoxynucleosldes as Potential Antcaids Agents (1989) (9)
- Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury. (2022) (8)
- P4-244 Discovery of a novel series of notch-sparing γ-secretase inhibitors (2006) (7)
- The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L. (2009) (7)
- Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation (2016) (7)
- Anabolism and Mechanism of Action of Ro24‐5098, an Isomer of 2′,3′‐Dideoxyadenosine (ddA) with Anti‐HIV Activity (1990) (7)
- A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. (2017) (6)
- Bulged DNA substrates for identifying poxvirus resolvase inhibitors (2012) (6)
- Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia. (2020) (5)
- A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement (2014) (4)
- CHAPTER 5 – Natural product chemistry and anticancer drug discovery (2008) (4)
- Treatment of Transplantation Rejection and Multiple Sclerosis (2007) (3)
- Women in Medicinal Chemistry Special Issue. (2019) (3)
- Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. (2010) (3)
- Women in Medicinal Chemistry Special Issue. (2019) (3)
- Author Correction: High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy (2020) (2)
- Synthesis and Anti‐HIV Activity of a Novel Series of Isomeric Dideoxynucleosides (1990) (2)
- Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury 1 2 3 (2015) (1)
- Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists” (2004) (1)
- A Different Kind of Medicinal Chemistry Toolbox. (2020) (1)
- Contributions of Academic Labs to the Discovery and Development of Chemical Biology Tools (2013) (1)
- Erratum: Molecular docking of cathepsin l inhibitors in the binding site of papain (Journal of Chemical Information and Modeling (2008) 48 (1464-1472)) (2010) (1)
- Special Issue on Epigenetics: Targeting Chromatin- and RNA- Modifications. (2020) (0)
- TOTAL SYNTHESIS OF (-)-GILMICOLIN (1985) (0)
- Heterocyclic, an azole-containing sulfonamide inhibitors of beta-amyloid production (2005) (0)
- Abstract 2083: Toxicity, bioavailability, pharmacokinetics, tissue distribution and metabolism of a novel small molecule inhibitor of IL-6-induced STAT3 activation (2016) (0)
- Based inhibitors heterocyclic sulfonamides of the production of beta amyloid containing an azole. (2005) (0)
- Author Correction: High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy (2020) (0)
- Virtual Special Issue: Epigenetics 2022. (2022) (0)
- Virtual Special Issue: Epigenetics 2022. (2022) (0)
- Cryo-EM structure of human p97 bound to ADP (2016) (0)
- Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists”: [Bioorg. Med. Chem. Lett. 14 (2004) 1651] (2004) (0)
- Medicinal chemistry in the pilot phase of the Molecular Libraries Screening Center Network. (2009) (0)
- High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy (2020) (0)
- Synthesis and Anti‐HIV Activity of Isonucleosides. (1992) (0)
- Virtual Special Issue: Epigenetics 2022. (2022) (0)
- Virtual Special Issue: Epigenetics 2022. (2022) (0)
- Cryo-EM structure of human p97 bound to ATPgS (Conformation III) (2016) (0)
- Virtual Special Issue: Epigenetics 2022. (2022) (0)
- Our scope expansion to include biologics. (2015) (0)
- Pharmaceutical Manufacturing: Sustainable Innovations to Produce Zero Waste (2020) (0)
- Synthesis of Iso-ddA, Member of a Novel Class of Anti-HIV Agents. (1990) (0)
- Virtual Special Issue: Epigenetics 2022. (2022) (0)
- Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor (2016) (0)
- Editorial [Hot topic: Medicinal Chemistry in the Pilot Phase of the Molecular Libraries Screening Center Network (Guest Editor: Donna M. Huryn)] (2009) (0)
- JPET #152975 1 TITLE: GSI-953 (begacestat): A novel, selective thiophene sulfonamide inhibitor of APP γ-secretase for the treatment of Alzheimer’s disease (2009) (0)
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