Douglas Cole
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Most Influential Person Now
Canadian historian
Douglas Cole 's AcademicInfluence.com Rankings
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History
Douglas Cole 's Degrees
- PhD History University of British Columbia
- Masters History University of British Columbia
- Bachelors History University of British Columbia
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Why Is Douglas Cole Influential?
(Suggest an Edit or Addition)According to Wikipedia, Douglas Lowell Cole was an American-Canadian historian. Cole specialized in the art and culture of the Northwest Pacific Coast, and from 1966 until 1997 served as a professor in the history department at Simon Fraser University.
Douglas Cole 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Quantitative capillary gel electrophoresis assay of phosphorothioate oligonucleotides in pharmaceutical formulations. (1994) (67)
- Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance (2003) (58)
- Selectivity of anion exchange chromatography and capillary gel electrophoresis for the analysis of phosphorothioate oligonucleotides. (1997) (47)
- Analysis of internal (n-1)mer deletion sequences in synthetic oligodeoxyribonucleotides by hybridization to an immobilized probe array. (1999) (46)
- ON THE FORMATION OF LONGMERS IN PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS (1997) (41)
- Sequence analysis of phosphorothioate oligonucleotides via matrix-assisted laser desorption ionization time-of-flight mass spectrometry. (1995) (36)
- Large-scale purification of antisense oligonucleotides by high-performance membrane adsorber chromatography. (2000) (30)
- Determination of free and encapsulated oligonucleotides in liposome formulated drug product. (2000) (28)
- Sequencing of oligonucleotide phosphorothioates based on solid- supported desulfurization (1994) (21)
- Application of sample displacement techniques to the purification of synthetic oligonucleotides and nucleic acids: a mini-review with experimental results (1998) (21)
- Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent (2003) (21)
- Controlled Detritylation of Antisense Oligonucleotides (2003) (20)
- Phosphorothioate oligonucleotides: Largely reduced (N-1)-mer and phosphodiester content through the use of dimeric phosphoramidite synthons (1997) (20)
- Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents. (1999) (19)
- Applications of green chemistry in the manufacture of oligonucleotide drugs (2001) (19)
- EFFICIENT SYNTHESIS OF ANTISENSE OLIGODEOXYRIBONUCLEOTIDE PHOSPHOROTHIOATES (1994) (18)
- Chemical Synthesis and Purification of Phosphorothioate Antisense Oligonucleotides (1999) (18)
- Synthesis of oligonucleotides via phosphoramidite approach utilizing 2-diphenylmethylsilylethyl (DPSE) as a phosphorus protecting group (1994) (17)
- Efficient synthesis of deoxyribonucleotide phosphorothioates by the use of DMT cation scavenger1 (1995) (17)
- Purification of antisense oligonucleotides. (2000) (17)
- Development and validation of a method for routine base composition analysis of phosphorothioate oligonucleotides. (1994) (16)
- Large-Scale Synthesis of Oligodeoxyribonucleotide Phosphorothioate Using Controlled-Pore Glass as Support (1995) (16)
- A Liquid-Phase Process Suitable for Large-Scale Synthesis of Phosphorothioate Oligonucleotides (2000) (14)
- Use of 2-diphenylmethylsilylethyl (DPSE) protecting group in oligonucleotide synthesis via phosphoramidite approach (1993) (14)
- Stereo-Reproducibility of the Phosphoramidite Method in the Synthesis of Oligonucleotide Phosphorothioates (1995) (13)
- Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation (2003) (12)
- Use of Phenylacetyl Disulfide (PADS) in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates (1999) (11)
- A CASE STUDY: OLIGONUCLEOTIDE PURIFICATION FROM GRAM TO HUNDRED GRAM SCALE (2001) (10)
- Development of 2‘-O-Methoxyethyl Phosphorothioate Oligonucleotides as Antisense Drugs under Stereochemical Control (2002) (10)
- Synthesis of Antisense Oligonucleotides with Minimum Depurination (2003) (10)
- Synthesis of antisense oligonucleotides. using environmentally friendly and safe deprotection procedures (1999) (9)
- Influence of Diastereomeric Ratios of Deoxyribonucleoside Phosphoramidites on the Synthesis of Phosphorothioate Oligonucleotides (2000) (9)
- 2-Diphenylmethylsilylethyl (DPSE): a versatile protecting group for oligodeoxyribonucleotide synthesis. (1994) (9)
- EFFORTS TOWARD SYNTHESIS OF OLIGONUCLEOTIDES FOR COMMERCIALIZATION (1997) (8)
- Large-Scale chromatographic purification of ougonucleotides (2000) (8)
- Diastereomeric Process Control in the Synthesis of 2′-O-(2-Methoxyethyl) Oligoribonucleotide Phosphorothioates as Antisense Drugs (2003) (8)
- Stability of phosphorothioate oligonucleotides in aqueous ammonia in presence of stainless steel. (1999) (7)
- A novel solid support for synthesis of oligonucleotide 3'-phosphorothioate monoesters. (2003) (7)
- Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis. (2003) (7)
- Improved Impurity Profile of Phosphorothioate Oligonucleotides Through the Use of Dimeric Phosphoramidite Synthons (1997) (6)
- Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time (2003) (6)
- Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages. (2000) (5)
- 4-Cyano-2-butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis via Phosphoramidite Approach (1996) (5)
- Oligodeoxyribonucleotide Phosphorothioates: Substantial Reduction of (N-1)-mer Content Through the Use of Trimeric Phosphoramidite Synthons (1999) (5)
- Synthesis and deprotection of β-silylethyl protected O,O,O- and O,O,S-trialkylphosphorothioates (1996) (4)
- Preclinical development of antisense therapeutics (1999) (4)
- 2-Methyl-5-tert-butylthiophenol—An Odorless Deprotecting Reagent Useful in Synthesis of Oligonucleotides and Their Analogs (2003) (4)
- Dimethoxytrityl Removal in Organic Medium: Efficient Oligonucleotide Synthesis Without Chlorinated Solvents (1999) (4)
- Synthesis of High Quality Phosphorothioate Oligonucleotides as Antisense Drugs. Use of I-Linker in the Elimination of 3′-Terminal Phosphorothioate Monoesters (2003) (4)
- Preparation of oligonucleotides without aldehyde abasic sites. (2001) (3)
- Sulfurization Efficiency in the Solution Phase Synthesis of Deoxyribonucleoside Phosphorothioates - Comparison of Sulfur Triethylamine with Various Sulfurizing Agents 1 (1996) (3)
- Understanding High Diastereomeric Discrimination in Formation of Oligoribonucleotide Phosphorothioate Linkages: The First Study of pKa-Dependent Activation in Solid-Supported Coupling of 2′-O-Substituted Ribonucleoside Phosphoramidites (2003) (3)
- Synthesis of Dimer Phosphoramidite Synthons for Oligodeoxyribonucleotide Phosphorothioates Using Diethyldithiocarbonate Disulfide as an Efficient Sulfurizing Reagent. (1999) (3)
- Improved Deproteciton Procedure for DPSE Protected Phosphorothioates (1998) (3)
- Diastereomeric Process Control in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates (1999) (2)
- Synthesis of ISIS 2105 Containing the Abasic Site Model Compound 1,4-Anhydro-2-deoxy-D-Ribitol (1994) (2)
- Synthesis of Deoxyribonucleoside Phosphorodithioate Dimers by a Triester Method (1999) (1)
- Special Issues for Synthetic Antisense Oligonucleotides (2000) (1)
- Analogs new trans-ciclopentanilpurina useful as immunosuppressants. (1992) (0)
- Efficient Synthesis of Deoxyribonucleoside Phosphoramidites by Eliminating the Use of Additional Activator. (1999) (0)
- Use of 2‐Diphenylmethylsilylethyl (DPSE) Protecting Group in Oligonucleotide Synthesis via Phosphoramidite Approach. (1994) (0)
- Synthese d'oligonucleotides (1995) (0)
- Methods for synthesizing sulfurized oligonucletidos (1998) (0)
- Antisense drugs: low-cost multi-ton manufacture for market (1997) (0)
- Process for the preparation of new immunosuppressive trans syklopentanyylipuriinianalogien (1992) (0)
- 2‐Methyl‐5‐tert‐butylthiophenol — An Odorless Deprotecting Reagent Useful in Synthesis of Oligonucleotides and Their Analogues. (2003) (0)
- Solution Phase Synthesis of an Oligodeoxyribonucleotide Phosphorothioate for Therapeutic Applications (1997) (0)
- Improved deprotection procedure for the synthesis of oligomer (1999) (0)
- Improved Deprotection Procedure for DPSE Protected Phosphorothioates. (1999) (0)
- Dulux New Zealand Ltd :Cartons of large photographs from the 'Press Photographer of the Year' award, 1978 and 1981 (1978) (0)
- Synthesis of Oligonucleotides via Phosphoramidite Approach Utilizing 2- Diphenylmethylsilylethyl (DPSE) as a Phosphorus Protecting Group. (1994) (0)
- Structural Investigation of Model Deadenylated Oligonucleotide Phosphorothioate Analog of Isis 2105 (1994) (0)
- Deprotection procedure for the synthesis of improved oligomeric compounds (1999) (0)
- Trans-cyclopentanylpurinanaloger useful as immunosuppressants (1992) (0)
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