Douglas M. Templeton

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Computer Science

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Computational Linguistics

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Machine Learning

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Artificial Intelligence

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Computer Science

Douglas M. Templeton's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Douglas M. Templeton's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000) (2000) (838)
Pharmacology (1941) (701)
Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major. (1998) (373)
Iron-chelation therapy with oral deferiprone in patients with thalassemia major. (1995) (303)
Multiple roles of cadmium in cell death and survival. (2010) (251)
Proteoglycans in cell regulation. (1992) (247)
[Gene targeting]. (1991) (189)
Interplay of calcium and cadmium in mediating cadmium toxicity. (2014) (179)
Sample collection guidelines for trace elements in blood and urine. IUPAC Commission of Toxicology. (1996) (171)
Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients (1990) (160)
Molecular and Cellular Iron Transport (2002) (148)
Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity. (1999) (133)
Growth failure and bony changes induced by deferoxamine. (1992) (132)
Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007) (2007) (129)
Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron. (1994) (122)
Genetic regulation of cell function in response to iron overload or chelation. (2003) (115)
Induction of c-fos Proto-oncogene in Mesangial Cells by Cadmium* (1998) (109)
Sample collection guidelines for trace elements in blood and urine (Technical Report) (1995) (105)
Protective elevations of glutathione and metallothionein in cadmium-exposed mesangial cells. (1993) (95)
Cadmium activates CaMK‐II and initiates CaMK‐II‐dependent apoptosis in mesangial cells (2007) (87)
Activation of parallel mitogen-activated protein kinase cascades and induction of c-fos by cadmium. (2000) (85)
Toxicological significance of metallothionein. (1991) (81)
Iron-balance and dose-response studies of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease. (1994) (81)
Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia (1992) (80)
Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. (1992) (79)
Cadmium uptake by cells of renal origin. (1990) (78)
The basis and applicability of the dimethylmethylene blue binding assay for sulfated glycosaminoglycans. (1988) (74)
Use of stable isotope ratios to distinguish sources of lead exposure in wild birds (1998) (74)
Glypicans: a growing trend (1996) (73)
High glucose alters actin assembly in glomerular mesangial and epithelial cells. (1995) (72)
Tentative reference values for nickel concentrations in human serum, plasma, blood, and urine: evaluation according to the TRACY protocol. (1994) (72)
Mitochondrial involvement in genetically determined transition metal toxicity I. Iron toxicity. (2006) (72)
Effects of iron loading on uptake, speciation, and chelation of iron in cultured myocardial cells. (1993) (71)
Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003) (2004) (70)
Ventilation (1900) (63)
Metallothionein synthesis and localization in relation to metal storage in rat liver during gestation. (1985) (63)
Brief report: combined liver and heart transplantation for end-stage iron-induced organ failure in an adult with homozygous beta-thalassemia. (1994) (61)
Modulation by iron loading and chelation of the uptake of non-transferrin-bound iron by human liver cells. (1995) (58)
Heparin Inhibits Mitogen-activated Protein Kinase-dependent and -independent c-fos Induction in Mesangial Cells* (1996) (58)
Calcium-independent effects of cadmium on actin assembly in mesangial and vascular smooth muscle cells. (1996) (57)
Initiation of caspase‐independent death in mouse mesangial cells by Cd2+: Involvement of p38 kinase and CaMK‐II (2008) (53)
Mitochondrial involvement in genetically determined transition metal toxicity II. Copper toxicity. (2006) (52)
Peptide and carbohydrate complexes of nickel in human kidney. (1985) (51)
Cellular factors mediate cadmium-dependent actin depolymerization. (1996) (51)
Changes in gene expression with iron loading and chelation in cardiac myocytes and non-myocytic fibroblasts. (2000) (51)
C-type Lectin (51)
Biomedical aspects of trace element speciation (1999) (48)
Follicular Atresia (2008) (47)
Subunit structure of bovine ESF (extracellular‐matrix stabilizing factor(s)) (1993) (45)
Characterization of Fe2+ and Fe3+ transport by iron-loaded cardiac myocytes. (1997) (45)
Phagocytosis (1892) (45)
Multielement analysis of biological samples by inductively coupled plasma-mass spectrometry. II. Rapid survey method for profiling trace elements in body fluids. (1991) (43)
Cadmium inhibits both intrinsic and extrinsic apoptotic pathways in renal mesangial cells. (2006) (43)
Chemical modifications of metallothionein. Preparation and characterization of polymers. (1984) (41)
Pleiotropic effects of cadmium in mesangial cells. (2009) (40)
Determination of Ni by ICP-MS: Correction of Calcium Oxide and Hydroxide Interferences Using Principal Components Analysis (1990) (40)
Differential accumulation of non-transferrin-bound iron by cardiac myocytes and fibroblasts. (2003) (39)
Copper complexation by 3-hydroxypyridin-4-one iron chelators: structural and iron competition studies. (1994) (37)
Inhibition of mitogenesis and c-fos induction in mesangial cells by heparin and heparan sulfates. (1996) (36)
Speciation of tissue and cellular iron with on-line detection by inductively coupled plasma-mass spectrometry. (1992) (36)
Metallothionein production: similar responsiveness of avian liver and kidney to chronic cadmium administration. (1990) (30)
Terminology of elemental speciation – An IUPAC perspective (2017) (30)
Growth modulation and proteoglycan turnover in cultured mesangial cells (1994) (29)
Cadmium and calcium-dependent c-fos expression in mesangial cells. (1998) (29)
Glossary of terms used in ecotoxicology (IUPAC Recommendations 2009) (2009) (28)
Chelation of intracellular calcium prevents mesangial cell proliferative responsiveness. (1998) (28)
Speciation in Metal Toxicity and Metal-Based Therapeutics (2015) (27)
Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton. (2006) (27)
Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins (2007) (27)
Heparin inhibits Ca2+/calmodulin-dependent kinase II activation and c-fos induction in mesangial cells. (1998) (27)
Effects of CdCl2 and Cd-metallothionein on cultured mesangial cells. (1992) (26)
The importance of trace element speciation in biomedical science (2003) (26)
Assessment of ICP-MS for routine multielement analysis of soil samples in environmental trace element studies (1990) (25)
Studies of the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one in thalassemia patients. (1990) (24)
Stress-activated protein kinase-dependent induction of c-fos by Cd(2+) is mediated by MKK7. (2000) (24)
Gamma Interferon (1995) (23)
Protective effect of cadmium-induced autophagy in rat renal mesangial cells (2018) (23)
Effects of divalent metals on the isolated rat glomerulus. (1990) (23)
Mechanisms of immunosensitization to metals (IUPAC Technical Report) (2004) (23)
Effects of cadmium on the actin cytoskeleton in renal mesangial cells. (2013) (23)
Heparin suppresses lipid raft‐mediated signaling and ligand‐independent EGF receptor activation (2007) (22)
Herpes (1891) (21)
Cadmium affects focal adhesion kinase (FAK) in mesangial cells: Involvement of CaMK‐II and the actin cytoskeleton (2013) (21)
Iron accumulation and iron-regulatory protein activity in human hepatoma (HepG2) cells (2004) (21)
[The ovarian follicle]. (1985) (21)
Fletcher-powell minimization of analytical potentiometric data by microcomputer: application to the Cu(II) complexes of biological polyamines (1985) (20)
Cadmium-induced glutathionylation of actin occurs through a ROS-independent mechanism: implications for cytoskeletal integrity. (2013) (20)
Role of the cytoskeleton in Cd2+-induced death of mouse mesangial cells. (2010) (20)
Collagen type I enhances endothelin-mediated contraction and induces nonproliferating phenotype in mesangial cells. (1996) (20)
Diagnostic relevance of the lymphocyte transformation test for sensitization to beryllium and other metals (IUPAC Technical Report) (2004) (19)
Oral iron chelation with 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron loaded thalassemia patients. (1993) (19)
Posttranscriptional effects of glucose on proteoglycan expression in mesangial cells. (1996) (19)
Iron transport and subcellular distribution in Hep G2 hepatocarcinoma cells. (1994) (19)
Retention of glomerular basement membrane-proteoglycans accompanying loss of anionic site staining in experimental diabetes. (1989) (19)
Iron-hydroxypyridone redox chemistry: kinetic and thermodynamic limitations to Fenton activity (1996) (18)
Interaction of toxic cations with the glomerulus: binding of Ni to purified glomerular basement membrane. (1987) (18)
Modulation of stellate cell proliferation and gene expression by rat hepatocytes: effect of toxic iron overload. (2003) (17)
Isotope-specific analysis of Ni by ICP-MS: applications of stable isotope tracers to biokinetic studies. (1994) (17)
Evaluation of the Oral Iron Chelator 1,2‐Dimethyl‐3‐hydroxypyrid‐4‐one (L1) in Iron‐Loaded Patients a (1990) (17)
GLOSSARY OF TERMS USED IN TOXICOLOGY, 2 nd EDITION (2007) (16)
Determination of nickel in serum and urine by inductively coupled plasma mass spectrometry (1993) (16)
Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesis and autophagy responses in models of type 1 diabetes. (2015) (16)
Cadmium favors F-actin depolymerization in rat renal mesangial cells by site-specific, disulfide-based dimerization of the CAP1 protein (2018) (15)
Inhibition of an iron‐responsive element/iron regulatory protein‐1 complex by ATP binding and hydrolysis (2007) (15)
Metal-binding properties of the isolated glomerular basement membrane. (1987) (15)
Explanatory dictionary of key terms in toxicology (IUPAC Recommendations 2007) (2007) (14)
Immunological effects of mercury (IUPAC Technical Report) (2009) (14)
Explanatory dictionary of key terms in toxicology: Part II (IUPAC Recommendations 2010) (2010) (14)
Suppression of mitogen-activated protein kinase phosphatase-1 (MKP-1) by heparin in vascular smooth muscle cells. (2003) (14)
Iron-loaded cardiac myocytes stimulate cardiac myofibroblast DNA synthesis (2006) (13)
Concepts in Toxicology (2009) (13)
Biosynthesis and metabolism of metallothionein in rat during perinatal development. (1987) (13)
Multifunctionality of lipoamide dehydrogenase: activities of chemically trapped monomeric and dimeric enzymes. (1981) (13)
Global genomic approaches to the iron-regulated proteome. (2005) (12)
Ca(2+)/calmodulin-dependent protein kinase II inhibition by heparin in mesangial cells. (2005) (12)
Use of inductively coupled plasma-mass spectrometry (icp-ms) for assessing trace element contamination in blood sampling devices (1989) (11)
Trace element speciation in toxicology and clinical sciences (1998) (11)
Involvement of CaMK‐IIδ and gelsolin in Cd2+‐dependent cytoskeletal effects in mesangial cells (2013) (11)
Structure and metabolism of multiple heparan sulphate proteoglycans synthesized by the isolated rat glomerulus. (1992) (11)
General occurrence of isosbestic points in the metachromatic dye complexes of sulphated glycosaminoglycans (1988) (10)
Measurement of platinum in biomedical silicones by ICP-MS (1995) (10)
Effects of zinc deficiency on pre-existing cadmium-metallothionein in the pancreas. (1984) (10)
Cadmium and hypertension (1983) (10)
Multielement analysis of biological samples by inductively coupled plasma-mass spectrometry (1989) (10)
Ca2+/calmodulin-dependent and cAMP-dependent kinases in induction of c-fos in human mesangial cells (2002) (10)
Multifunctionality of lipoamide dehydrogenase promotion of electron transferase reaction. (1983) (10)
Properties and units in the clinical laboratory sciences: Part IX. Properties and units in trace elements (Technical Report) (1997) (9)
Nickel binding to the C-terminal tryptic fragment of a peptide from human kidney. (1986) (9)
Cytokine profiles in human exposure to metals (IUPAC Technical Report) (2006) (9)
Electrochemical oxidation of some therapeutic 3-hydroxypyridin-4-one iron chelators (1993) (9)
Heparan sulfate chains with antimitogenic properties arise from mesangial cell-surface proteoglycans. (1999) (9)
Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state. (2010) (9)
Heterogeneity in the response of vascular smooth muscle to heparin: altered signaling in heparin-resistant cells. (2000) (9)
The reaction of metallothionein with mercuribenzoate. A dialysis and 113Cd-n.m.r. study. (1986) (8)
Effects of retinol and hepatocyte-conditioned medium on cultured rat hepatic stellate cells. (2003) (8)
Conserved charge of glomerular and mesangial cell proteoglycans: possible role of amino acid-derived sulphate. (1992) (8)
Cadmium-induced aggregation of iron regulatory protein-1. (2014) (8)
Activation and regulation of the insulin receptor kinase. (1992) (8)
MECHANISMS OF IMMUNOSENSITIZATION TO METALS (2004) (8)
Increased microalbuminuria in diabetic rats is independent of angiotensin II or glomerular proteoglycan synthesis. (1992) (8)
Quantifying cadmium and lead in whole blood. (1992) (8)
Hernia (1890) (7)
A Northwestern blotting approach for studying iron regulatory element-binding proteins (2005) (7)
The effects of cardiac myocytes on interstitial fibroblasts in toxic iron overload (2007) (7)
Therapeutic Use of Chelating Agents in Iron Overload (1995) (6)
IMMUNOLOGICAL EFFECTS OF MERCURY (2009) (6)
Immunodiagnostics and immunosensor design (IUPAC Technical Report) (2014) (6)
Inactivation of kinase cascades in mesangial cells grown on collagen type I. (1998) (6)
IUPAC Glossary of Terms Used In Toxicology, 2nd Edition - toxicokinetics, toxicology, chemistry, risk assessment, hazard assessment, chemical terminology (2007) (6)
Measurement of total nickel in body fluids: Electrothermal atomic absorption methods and sources of preanalytic variation (Technical Report) (1994) (6)
Synthesis of heparan sulfate proteoglycans by the isolated glomerulus. (1988) (6)
Lymphocyte subpopulations in human exposure to metals (IUPAC Technical Report) (2008) (6)
Variability of proteoglycan expression in the isolated rat glomerulus. (1990) (6)
Journal of the Royal Institute of Chemistry. October 1956 (1956) (6)
Acceleration of the mercury-induced aquation of bromopentammine Co(III) by naturally occurring glycosaminoglycans (1987) (5)
Transport of iron chelators and chelates across MDCK cell monolayers: implications for iron excretion during chelation therapy (2010) (5)
Chemical modifications of metallothionein, II. Metabolic fate of cadmium bound to metallothionein polymers. (1985) (5)
LYMPHOCYTE SUBPOPULATIONS IN HUMAN EXPOSURE TO METALS (2008) (5)
Multifunctionality of lipoamide dehydrogenase: lysine residue and cationic environment. (1981) (5)
Cadmium Interaction with Animal Cells (2018) (5)
Transport of Non-Transferrin-Bound Iron by Hepatocytes (2002) (5)
Histidine at the active centre of pig heart lipoamide dehydrogenase. (1979) (5)
Cell density-dependent shift in activity of iron regulatory protein 1 (IRP-1)/cytosolic (c-)aconitase. (2012) (5)
Reversed-phase high-performance liquid chromatography of non-transferrin-bound iron and some hydroxypyridone and hydroxypyrone chelators. (1994) (5)
Marginal Zone (2022) (4)
International Union of Pure and Applied Chemistry and International Federation of Clinical Chemistry, Committee on Nomenclature. Properties and Units (C-NPU): properties and units in the clinical laboratory sciences. IX. Properties and units in trace elements (IFCC-IUPAC technical report 1997). (1997) (4)
Nickel at the renal glomerulus : molecular and cellular interactions (1992) (4)
Iron-dependent turnover of IRP-1/c-aconitase in kidney cells. (2015) (4)
Selected Examples of Important Metal–Protein Species (2005) (4)
CYTOKINE PROFILES IN HUMAN EXPOSURE TO METALS (2006) (4)
IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012) (2012) (3)
IUPAC GLOSSARY OF TERMS USED IN TOXICOLOGY - EXPANDED AND REVISED FROM "GLOSSARY FOR CHEMISTS OF TERMS USED IN TOXICOLOGY", 1993 (1) (IUPAC RECOMMENDATIONS) (2006) (3)
Comprehensive Glossary of Terms Used in Toxicology (2018) (3)
Ca(2+)/calmodulin-dependent and cAMP-dependent kinases in induction of c-fos in human mesangial cells. (2002) (3)
Myasthenia (1900) (3)
Eczema (1891) (3)
Nephrosis (1931) (3)
Chapter 21 Nickel (1994) (3)
Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016) (2016) (2)
What is an Endocrine Disrupter ? (2014) (2)
Comparative studies of glutathione reductase and lipoamide dehydrogenase. (1988) (2)
Elemental Speciation in Clinical Sciences (2012) (2)
Interactions of Cadmium with Signaling Molecules (2018) (2)
Structural aspects of molecular recognition in the immune system. Part I: Acquired immunity (IUPAC Technical Report) (2014) (2)
International Union of Pure and Applied Chemistry Clinical Chemistry Division, Commission on Toxicology (C-TOX), Commission on Nomenclature, Properties and Units (C-NPU) and International Federation of Clinical Chemistry, Scientific Division Committee on Nomenclature, Properties and Units (C-NPU)2 (1997) (2)
Sulfate metabolism in experimental diabetes. (1992) (2)
IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015) (2015) (2)
Low‐concentration heparin suppresses ionomycin‐activated CAMK‐II/EGF receptor‐ and ERK‐mediated signaling in mesangial cells (2010) (2)
Low molecular weight targets of metals in human kidney. (2009) (1)
Applications of immunochemistry in human health: advances in vaccinology and antibody design (IUPAC Technical Report) (2014) (1)
Inactivation of kinase cascades in mesangial cells grown on collagen type I. (1998) (1)
Kinetic and spectroscopic studies of transhydrogenase activity and nucleotide site of lipoamide dehydrogenase. (1985) (1)
Physicochemical and metabolic properties of modified metallothioneins. (1984) (1)
Disturbance Ecology (2020) (1)
Magnetic circular dichroism studies on the active-site flavin of lipoamide dehydrogenase. (1980) (1)
Genetic Defects in Iron and Copper Trafficking (2010) (1)
Evaluation of the integrity of the blood-brain barrier after meningeal trauma. (1992) (1)
Implantation (1887) (0)
Urticaria (1890) (0)
Medicine (1936) (0)
Cancer (1906) (0)
Undergraduate Specialist Program in Pathobiology at the University of Toronto (2017) (0)
Glossary of Terms Used in Toxicology, 2nd Edition: (IUPAC Recommendations 2007) (2020) (0)
Idiosyncrasy (1909) (0)
HISTOLOGY (1954) (0)
The role of iron in regulating gene expression (1997) (0)
Protective effect of cadmium-induced autophagy in rat renal mesangial cells (2017) (0)
Immunochemical Recognition and its Diagnostic and Therapeutic Applications (2015) (0)
Aneurysm (1908) (0)
IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015) (2015) (0)
Umbilical Hernia (1904) (0)
POLYMYOSITIS (1958) (0)
Hygiene (1857) (0)
Cataract (1903) (0)
Antigen recognition. (1997) (0)
Shellfish poisoning. (1970) (0)
Folic Acid. (1948) (0)
Properties and Units in the Clinical Laboratory Sciences. IX. Properties and Units in Trace Elements (IUPAC-IFCC Technical report 1997). International Union of Pure and Applied Chemistry and International Federation of Clinical Chemistry. rita.cornelis@rug.ac.be. (1997) (0)
Macroglossia (1903) (0)
Toxicology (1837) (0)
Ca /calmodulin-dependent and cAMP-dependent kinases in induction of c-fos in human mesangial cells (2002) (0)
BIOLOGICAL warfare. (1952) (0)
Inflammation (1907) (0)
Agranulocytosis (1935) (0)
Glossary of Terms Used in Molecular Toxicology (2021) (0)
Immunochemical Recognition and Applications (2014) (0)
Immune Evasion (2003) (0)
IUPAC Glossaries in Toxicology (2014) (0)
Genetic determinants of trace element metabolism. (1999) (0)
Appendicular Skeleton (2021) (0)
Clinical studies on iron chelation in patients with thalassemia major. (1990) (0)
Population Statistics (1937) (0)
SCOLIOSIS (1967) (0)
Death Rate (1873) (0)
PHARMACOLOGY (1975) (0)
Carrying Capacity (2021) (0)
[Parkinson disease]. (2021) (0)
Solvent abuse. (1982) (0)
Reaction Time (2020) (0)
Concepts in Toxicology: Development of Online Instructional Modules (2015) (0)
Preparation and characterization of polymers (2005) (0)
Recombinant DNA. (1980) (0)
The Use of IUPAC Names in Glossaries (2016) (0)
Passive Immunization (2012) (0)
by heparin in mesangial cells /calmodulin-dependent protein kinase II inhibition (2016) (0)
THE COOMBS test. (1957) (0)
Acceleration of ionic reactions by naturally occurring glycosaminoglycans. II. (1988) (0)
Systematic Sample (2021) (0)
Leprosy (2016) (0)
Cadmium favors F-actin depolymerization in rat renal mesangial cells by site-specific, disulfide-based dimerization of the CAP1 protein (2017) (0)
Acromegaly (1932) (0)
List of Contributors (2020) (0)
Glossary of Terms Used in Neurotoxicology (2015) (0)

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