Douglas Cavener
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Evolutionary Genetics researcher
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Douglas Cavenerbiology Degrees
Biology
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Evolutionary Biology
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Biology
Douglas Cavener's Degrees
- PhD Biology University of California, San Diego
- Bachelors Biology University of California, San Diego
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Why Is Douglas Cavener Influential?
(Suggest an Edit or Addition)According to Wikipedia, Douglas R. Cavener is an American biologist, a Professor of Biology and the former Verne M. Willaman Dean Professor of Science at Eberly College of Science, Pennsylvania State University, and also a published author, being widely cited and widely held in libraries.
Douglas Cavener's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006) (982)
- Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. (1987) (895)
- The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas (2002) (602)
- Eukaryotic start and stop translation sites. (1991) (572)
- Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response (2004) (499)
- The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice (2002) (429)
- Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses (2003) (368)
- Suppression of eIF2α kinases alleviates AD-related synaptic plasticity and spatial memory deficits (2013) (349)
- Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism (2006) (346)
- Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex (2005) (338)
- Translational control and the unfolded protein response. (2007) (289)
- A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. (2000) (288)
- PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. (2006) (275)
- The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. (2007) (262)
- PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage (2010) (261)
- Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. (1992) (257)
- Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. (2003) (253)
- Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2* (2010) (240)
- PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation (2008) (234)
- GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. (1992) (230)
- Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2* (2004) (219)
- Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK (2001) (199)
- PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. (2006) (160)
- Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. (2012) (129)
- PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway (2010) (122)
- GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase* (2009) (115)
- PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation (2008) (115)
- Proinsulin Disulfide Maturation and Misfolding in the Endoplasmic Reticulum* (2005) (108)
- Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis* (2008) (106)
- Suppression of eIF2 a kinases alleviates Alzheimer’s disease–related plasticity and memory deficits (2013) (105)
- New Ways of Initiating Translation in Eukaryotes? (2001) (104)
- Tryptophan catabolism generates autoimmune-preventive regulatory T cells. (2006) (103)
- Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation (1997) (95)
- MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER (1981) (92)
- PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice (2007) (87)
- Dynamics of correlated genetic systems. IV. Multilocus effects of ethanol stress environments. (1978) (85)
- Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster. (1981) (82)
- Insulin Secretion and Ca2+ Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin* (2013) (80)
- Endoplasmic Reticulum Stress Sensor Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload–Induced Heart Failure and Lung Remodeling (2014) (73)
- eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. (2009) (73)
- A Mammalian Homologue of GCN 2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2 a (2000) (71)
- PERK in beta cell biology and insulin biogenesis (2010) (63)
- Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease (2016) (61)
- 25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages* (2013) (58)
- Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster. (1983) (58)
- The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression (2014) (57)
- PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. (2003) (55)
- Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation (2009) (55)
- Hyperthermia Induces the ER Stress Pathway (2011) (55)
- Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster (2004) (53)
- Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. (1998) (52)
- Expansion and evolution of insect GMC oxidoreductases (2007) (52)
- The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration (2017) (50)
- PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice (2009) (50)
- A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster. (1986) (44)
- Genetic inactivation of PERK signaling in mouse oligodendrocytes: Normal developmental myelination with increased susceptibility to inflammatory demyelination (2014) (42)
- Binding analysis of the estrogen receptor to its specific DNA target site in human breast cancer. (1991) (40)
- Giraffe genome sequence reveals clues to its unique morphology and physiology (2016) (40)
- Genomic DNA analysis of the estrogen receptor gene in breast cancer (1989) (37)
- The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development. (1992) (37)
- Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. (1995) (36)
- The Response of Enzyme Polymorphisms to Developmental Rate Selection in DROSOPHILA MELANOGASTER. (1983) (36)
- Evolution of the glucose dehydrogenase gene in Drosophila. (1990) (34)
- Isolation of the eclosion gene cluster and the developmental expression of the Gld gene in Drosophila melanogaster. (1986) (32)
- Transgenic animal studies on the evolution of genetic regulatory circuitries (1992) (32)
- Ecdysteroid regulation of glucose dehydrogenase and alcohol dehydrogenase gene expression in Drosophila melanogaster. (1989) (32)
- Temporal Stability of Allozyme Frequencies in a Natural Population of DROSOPHILA MELANOGASTER. (1981) (29)
- The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones (2018) (28)
- Evolution of the expression of the Gld gene in the reproductive tract of Drosophila. (1992) (26)
- Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster. (1990) (24)
- Correlated evolution of the cis-acting regulatory elements and developmental expression of the Drosophila Gld gene in seven species from the subgroup melanogaster. (1994) (23)
- Dietary Modulation of Glucose-6-Phosphate Dehydrogenase and 6-Phosphogluconate Dehydrogenase in Drosophila (1981) (23)
- Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions (2014) (22)
- Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse (2016) (21)
- Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon (1991) (21)
- Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determination genes. (1991) (19)
- GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis. (2013) (16)
- Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster. (1988) (16)
- Coevolution of the glucose dehydrogenase gene and the ejaculatory duct in the genus Drosophila. (1985) (16)
- Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice (2020) (15)
- 5 Nutrient signaling through mammalian GCN2 (2004) (15)
- Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2. (1994) (14)
- Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster (1980) (14)
- Detection of estrogen receptor mRNA in human uterus (1987) (14)
- PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility (2016) (14)
- Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene. (2001) (13)
- Seeing spots: quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis) (2018) (13)
- PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons (2016) (12)
- Combinatorial control of structural genes in Drosophila: Solutions that work for the animal (1987) (12)
- GCN2 in the Brain Programs PPARγ2 and Triglyceride Storage in the Liver during Perinatal Development in Response to Maternal Dietary Fat (2013) (11)
- COMMUNICATION Brain ischemia and reperfusion activates the eukaryotic initiation factor 2a kinase, PERK (2001) (11)
- Correction: PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice (2009) (11)
- Dynamics of Correlated Genetic Systems. VII. Demographic Aspects of Sex-Linked Transmission (1982) (10)
- Evolution of Developmental Regulation (1989) (10)
- Induce a Regulatory Phenotype in Naive T-Chain and ζ DownRegulate T Cell Receptor Starvation and Tryptophan Catabolites The Combined Effects of Tryptophan Puccetti (2006) (9)
- Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster. (1997) (9)
- Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi (2017) (8)
- Tissue-specific regulatory elements of the Drosophila Gld gene (1993) (8)
- Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2β (1994) (7)
- The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes. (1988) (7)
- Genetic connectivity and population structure of African savanna elephants (Loxodonta africana) in Tanzania (2020) (6)
- Sleeping Beauty, Awake! Regulation of Insulin Gene Expression by Methylation of Histone H3 (2009) (6)
- EIF 2 AK 3 control of pancreatic b cell differentiation and proliferation is required for postnatal glucose homeostasis (6)
- Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes. (1991) (5)
- An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression. (1994) (4)
- A somatic reproductive organ enhancer complex activates expression in both the developing and the mature Drosophila reproductive tract. (1996) (3)
- Chronic granulomatous disease (1987) (2)
- Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy (2021) (2)
- Analysis of the estrogen receptor (ER) gene, transcript and protein in ER-positive and -negative breast cancer cell lines (1995) (2)
- The genetics of glutamate oxaloacetate transaminase in Drosophila melanogaster. (1976) (2)
- Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases (2020) (1)
- Deletion of PERK in Liver Impairs the Hepatic ER Stress Response to Tunicamycin. (2009) (1)
- Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta. (1994) (1)
- The "Giraffe Paradox": What Humans Can Learn from Giraffe in Heart Failure (2017) (1)
- Response of theG6pd and6Pgd polymorphisms inDrosophila melanogaster to dietary selection (2004) (1)
- Seeing spots: Measuring, quantifying heritability, and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis) (2017) (1)
- Masai giraffe population change over 40 years in Arusha National Park (2023) (1)
- PERK regulates insulin secretion and Ca 2 + dynamics 1 Insulin secretion and Ca 2 + dynamics in β-cells are regulated by PERK eIF 2 α kinase in concert with calcineurin (2013) (1)
- REPEATED GEOGRAPHIC VARIATION AT THREE ENZYME LOCI IN THE AMPHIPOD (2010) (1)
- The Developmental Genetic Basis of Organismal Evolution@@@Embyros, Genes, and Evolution. (1983) (0)
- PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons (2016) (0)
- Using spot pattern recognition to examine population biology, evolutionary ecology, sociality, and movements of giraffes: a 70-year retrospective (2022) (0)
- PHOSPHOGLUCONATE DEHYDROGENASE IN DROSOPHILA (1981) (0)
- upstream of the AUG initiator codon. melanogaster is reduced by mutations Translation initiation in Drosophila (2013) (0)
- Nucleic Acids Research Nucleic Acids Research (2003) (0)
- The Pennsylvania State University The Graduate School Eberly College of Science CHARACTERIZATION OF A NOVEL NEUROTRANSMITTER PHENOTYPIC PLASTICITY IN THE CENTRAL NERVOUS SYSTEM (2008) (0)
- THE GCN 2 EIF 2 ALPHA KINASE REGULATES LIPID AND GLUCOSE HOMEOSTASIS (2011) (0)
- Referees for volume 31 (1993) (0)
- THE EFFECTS OF LEUCINE DEPRIVATION AND CALORIC RESTRICTION ON THE HUMAN METABOLISM (2010) (0)
- Volume 16 Number 8 1988 Nucleic Acids Research The YYRR box : a conserved dipyrimidine — djpurine sequence element in Drosophila and other eukaryotes (2005) (0)
- Isolation of genes encoding proteins of immunological importance. (1987) (0)
- in mouse liver mRNAs transcription and translation of distinct sets of kinases GCN2 and PERK modulate (2015) (0)
- THEODOSIUS DOBZHANSKY PRIZE AWARDED (1981) (0)
- Referees for volume 31 (2021) (0)
- Author response: The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration (2017) (0)
- The Pennsylvania State University The Graduate School Eberly College of Science COFILIN RODS AND NEURODEGENERATION (2009) (0)
- Isolation oftheeclosion genecluster andthedevelopmental expression oftheGldgeneinDrosophila melanogaster (1986) (0)
- THE DEVELOPMENTAL GENETIC BASIS OF ORGANISMAL EVOLUTION. (1983) (0)
- Diverse Cellular Stresses B in Response to κ for Activation of NF-Eukaryotic Initiation Factor 2 Is Required Subunit of α Phosphorylation of the (2003) (0)
- Immune development in mice fed diets complete in amino acids or lacking the essential amino acid (EAA) leucine is regulated by the eIF2 kinase GCN2 (2007) (0)
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