Douwe Breimer | Academic Influence

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Douwe Breimer

Medical

#813

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#1065

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Pharmacology

#49

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#68

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Douwe Breimer's Degrees

PhD Pharmacology Leiden University

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According to Wikipedia, Douwe Durk Breimer is a Dutch pharmacologist and was both rector magnificus and president of the Executive Board of Leiden University, The Netherlands. Breimer studied pharmacology at the University of Groningen and obtained his Ph.D. from the Catholic University of Nijmegen. In 1975, he was appointed professor of pharmacology at Leiden University. His research focusses on pharmacokinetics, pharmacodynamics and drug metabolism. Breimer co-authored over 500 scientific papers and supervised more than 50 Ph.D. students.

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Douwe Breimer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The influence of cytokines on the integrity of the blood-brain barrier in vitro (1996) (619)
Drug transport across the blood-brain barrier (1992) (508)
The blood-brain barrier in neuroinflammatory diseases. (1997) (432)
Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. (1998) (366)
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. (2000) (356)
Therapeutic Drug Monitoring in Saliva (1978) (324)
Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. (2001) (304)
Methodological issues in microdialysis sampling for pharmacokinetic studies. (2000) (246)
Nifedipine: Kinetics and dynamics in healthy subjects (1984) (230)
Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier (1997) (221)
Pharmacokinetic‐pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α‐hydroxymidazolam in healthy volunteers (1992) (211)
Rectal Drug Administration (1982) (201)
Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans (1987) (196)
Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man. (1984) (177)
Assay of antipyrine and its primary metabolites in plasma, saliva and urine by high-performance liquid chromatography and some preliminary results in man. (1979) (173)
Drug absorption by sublingual and rectal routes. (1984) (159)
Pharmacokinetics of Rectal Drug Administration, Part I (1991) (156)
The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane. (1980) (156)
Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs. (1988) (150)
The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. (1978) (143)
Topics in Pharmaceutical Sciences (1982) (142)
Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4,4'-dihydroxyantipyrine. (1983) (135)
Intestinal drug absorption enhancement: an overview. (1989) (134)
Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans (1991) (132)
Studies on the different metabolic pathways of antipyrine in rats: influence of phenobarbital and 3-methylcholanthrene treatment. (1979) (132)
Relevance of the Application of Pharmacokinetic-Pharmacodynamic Modelling Concepts in Drug Development (1997) (125)
Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood–brain barrier (2001) (124)
A comparison of the sensitivities of adaptive tracking, eye movement analysis, and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers (1991) (124)
Astrocytes Increase the Functional Expression of P-Glycoprotein in an In Vitro Model of The Blood-Brain Barrier (2000) (123)
Pharmacokinetics of Rectal Drug Administration, Part II (1991) (118)
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. (2000) (112)
NEGLIGIBLE SUBLINGUAL ABSORPTION OF NIFEDIPINE (1987) (112)
Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain (1994) (111)
Effects of the Mucoadhesive Polymer Polycarbophil on the Intestinal Absorption of a Peptide Drug in the Rat (1992) (106)
Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysis (1974) (105)
Nifedipine: Kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration (1986) (104)
The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation (1999) (104)
Interindividual Variations in Drug Disposition (1983) (98)
Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects. (1988) (98)
Pharmacokinetics of methohexitone following intravenous infusion in humans. (1976) (93)
Rectal bioavailability of lidocaine in man: Partial avoidance of “first‐pass” metabolism (1979) (92)
Influence of sex, menstrual cycle and oral contraception on the disposition of nitrazepam. (1982) (90)
Differential effects of enzyme induction on antipyrine metabolite formation. (1982) (89)
Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview. (1988) (88)
BBB Transport and P-glycoprotein Functionality Using MDR1A (-/-) and Wild-Type Mice. Total Brain Versus Microdialysis Concentration Profiles of Rhodamine-123 (1998) (85)
Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation. (1979) (82)
Pharmacokinetic and pharmacodynamic interactions of bretazenil and diazepam with alcohol. (2003) (82)
Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro. (1996) (82)
Future challenges for drug delivery. (1999) (82)
Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator (1992) (81)
Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro. (2003) (80)
Pharmacokinetics of Lignocaine and Bupivacaine in Surgical Patients Following Epidural Administration (1987) (79)
Evaluation of Orally Administered Highly Variable Drugs and Drug Formulations (1996) (77)
Studies on the different metabolic pathways of antipyrine in man. I. Oral administration of 250, 500 and 1000 mg to healthy volunteers. (1979) (75)
A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans. (1990) (75)
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design. (1989) (75)
Nifedipine. Relationship between pharmacokinetics and pharmacodynamics. (1987) (74)
Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy. (1993) (72)
Eicosanoid production by rat cerebral endothelial cells: Stimulation by lipopolysaccharide, interleukin-1 and interleukin-6 (1995) (71)
The occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in Drosophila melanogaster microsomes, and the importance of this metabolizing capacity for the screening of carcinogenic and mutagenic properties of foreign compounds. (1977) (71)
Identification in hashish of tetrahydrocannabinol, cannabidiol and cannabinol analogues with a methyl side‐chain (1972) (71)
The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione. (1981) (70)
Cell-polarity dependent effect of chelation on the paracellular permeability of confluent caco-2 cell monolayers (1993) (69)
Pharmacokinetics and metabolism of various benzodiazepines used as hypnotics. (1979) (68)
Influence of rifampicin on drug metabolism: Differences between hexobarbital and antipyrine (1977) (67)
Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain (1995) (66)
The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo. (1981) (65)
Nifedipine: Influence of renal function on pharmacokinetic/hemodynamic relationship (1985) (64)
Pharmacokinetic Interactions with Rifampicin (1977) (58)
Liquid chromatographic determination of nifedipine in plasma and of its main metabolite in urine. (1998) (58)
Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy male subjects. (1990) (58)
Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance (1975) (58)
Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat. (1994) (56)
Lymphocyte adhesion to brain capillary endothelial cells in vitro (1994) (55)
Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects (2004) (55)
Brain Penetration and In Vivo Recovery of NMDA Receptor Antagonists Amantadine and Memantine: A Quantitative Microdialysis Study (1999) (55)
Formation of mercapturic acids from acrylonitrile, crotononitrile, and cinnamonitrile by direct conjugation and via an intermediate oxidation process. (1981) (55)
The blood-brain barrier and multiple sclerosis. (1994) (54)
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach. (1988) (54)
Pharmacodynamic interactions of diazepam and intravenous alcohol at pseudo steady state (2005) (51)
Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans (1991) (50)
Nifedipine kinetics and dynamics during rectal infusion to steady state with an osmotic system (1984) (50)
Pharmacokinetics of benzodiazepines. Short-acting versus long-acting. (1980) (50)
Rapid and sensitive gas chromatographic determination of hexobarbital in plasma of man using a nitrogen detector. (1974) (49)
Enantioselective determination of felodipine and other chiral dihydropyridine calcium entry blockers in human plasma. (1990) (45)
The disposition of antipyrine and its metabolites in young and elderly healthy volunteers. (1987) (45)
Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cells. (1989) (44)
Hexobarbital disposition in compensated and decompensated cirrhosis of the liver (1978) (44)
Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green. (1991) (44)
Effects of temazepam on saccadic eye movements: Concentration‐effect relationships in individual volunteers (1992) (43)
Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability (1995) (42)
INTERACTION BETWEEN PARACETAMOL AND COUMARIN ANTICOAGULANTS (1982) (42)
Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine (1988) (41)
High-density lipoprotein and cerebral endothelial cells in vitro: interactions and transport. (1995) (41)
Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo. (1983) (40)
Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation. (1981) (39)
Pharmacokinetics and metabolism of anthraquinone laxatives. (1976) (39)
Nifedipine: variability in its kinetics and metabolism in man. (1989) (39)
Mutagenic activation of dibromomethane and diiodomethane by mammalian microsomes and glutathione S-transferases. (1980) (39)
Topical effects of absorption enhancing agents on the rectal mucosa of rats in vivo. (1990) (38)
Physical Exercise Induces Enhancement of Urokinase-Type Plasminogen Activator (u-PA) Levels in Plasma (1991) (38)
Identification of cannabivarins in hashish by a new method of combined gas chromatography-mass-spectrometry. (1971) (38)
Role of Environmental Factors in the Pharmacokinetics of Drugs: Considerations with Respect to Animal Models, P-450 Enzymes, and Probe Drugs (1994) (38)
Strain-differences and inducibility of microsomal oxidative enzymes in Drosophila melanogaster flies. (1984) (38)
Chapter 20 Cytokines and blood-brain barrier permeability (1998) (37)
Rectal bioavailability of lidocaine in rats: absence of significant first-pass elimination. (1980) (37)
In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport Inhibitors (1994) (37)
Kinetics of five benzodiazepine hypnotics in healthy subjects (1983) (37)
Pharmacokinetics of etomidate in surgical patients. (1981) (37)
Preliminary studies on the ability of Drosophila microsomal preparations to activate mutagens and carcinogens. (1980) (36)
In vivo oxidative cleavage of a pyridine-carboxylic acid ester metabolite of nifedipine. (1989) (35)
PHARMACOKINETICS AND NEPHROTOXICITY OF CYCLOSPORINE IN RENAL TRANSPLANT RECIPIENTS (1985) (35)
Clinical Pharmacokinetics of Nitrazepam (1981) (35)
The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain (1995) (35)
Assay of underivatized intrazepam and clonazepam in plasma by capillary gas chromatography applied to pharmacokinetic and bioavailability studies in humans. (1978) (35)
Gas chromatographic determination of nisoldipine and one of its metabolites in plasma. (1987) (33)
Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. (2001) (33)
The transference of results between blood-brain barrier cell culture systems. (1999) (33)
Glutathione S-transferase activity in rat and human tissues and organs. (1981) (33)
Glutathione S-transferase activity in human fetal and adult tissues. (1981) (32)
Xenobiotica-metabolizing enzymes in Drosophila melanogaster: activities of epoxide hydratase and glutathione S-transferase compared with similar activities in rat liver. (1979) (32)
Pharmacokinetics of brotizolam in healthy subjects following intravenous and oral administration. (1983) (32)
Cannabinoids with a Propyl Side Chain in Cannabis: Occurrence and Chromatographic Behavior (1972) (32)
Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats. (1992) (31)
Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology (1991) (31)
Characterization of the Scavenger Receptor on Bovine Cerebral Endothelial Cells In Vitro (1993) (31)
Pharmacokinetics of brotizolam in the elderly. (1983) (31)
Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans. (2000) (31)
Comparative pharmacokinetics of brotizolam and triazolam in healthy subjects. (1983) (30)
Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats (1999) (30)
Gas chromatography of cannabis constituents and their synthetic derivatives. (1972) (29)
The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat. (1981) (29)
Analysis of nifedipine and its pyridine metabolite dehydronifedipine in blood and plasma: review and improved high-performance liquid chromatographic methodology. (1991) (28)
PLASMA LEVEL PROFILE OF NITRAZEPAM (MOGADON®) FOLLOWING ORAL ADMINISTRATION (1977) (28)
Pharmacokinetics and hemodynamic effects of long-term nisoldipine treatment in hypertensive patients. (1989) (28)
Studies of the different metabolic pathways of antipyrine in man (1982) (28)
Plasma Concentrations of Lidocaine and Bupivacaine after Subarachnoid Administration (1983) (28)
P-Glycoprotein Inhibition Leads to Enhanced Disruptive Effects by Anti-Microtubule Cytostatics at the In Vitro Blood-Brain Barrier (2001) (28)
Avoidance of first pass elimination of propranolol after rectal administration to rats (1981) (27)
The influence of infusion rate on the pharmacokinetics and haemodynamic effects of nisoldipine in man. (1988) (27)
Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats. (1983) (26)
Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration. (1999) (26)
Rate‐controlled Absorption Enhancement of Rectally Administered Cefazolin in Rats by a Glyceride Mixture (MGK) (1988) (26)
Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells (1994) (26)
Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: A study in healthy volunteers (1988) (26)
Rate-controlled rectal drug delivery in man with a hydrogel preparation (1986) (25)
Cytokines and blood-brain barrier permeability. (1998) (25)
The epoxide-diol pathway in the metabolism of hexobarbital in rat and man. (1979) (25)
Pharmacokinetics of (+)‐, (−)‐ and (±)‐hexobarbitone in man after oral administration (1973) (24)
In vivo characterization and modulation of the glutathione/glutathione S-transferase system in cancer patients. (1995) (24)
The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: microdialysis and maximum electroshock seizures studies. (1999) (24)
PK/PD Modelling and Beyond: Impact on Drug Development (2008) (23)
Assay of triazolam in plasma by capillary gas chromatography. (1981) (23)
Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia. (1983) (23)
THE SYNTHESIS OF MERCAPTURIC ACIDS AND THEIR ESTERS (1981) (22)
Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration. (1986) (22)
The Blood-Brain Barrier: Clinical Implications for Drug Delivery to the Brain (1994) (22)
Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance (1977) (22)
Oral absorption profile of nitrendipine in healthy subjects: a kinetic and dynamic study. (1989) (21)
Effect of anisotonic conditions on the transport of hydrophilic model compounds across monolayers of human colonic cell lines. (1994) (21)
The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay. (1993) (21)
Transporters and the blood-brain barrier (BBB). (1998) (21)
Influence of allylisopropylacetamide and phenobarbital treatment on in vivo antipyrine metabolite formation in rats. (1983) (21)
Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers. (1995) (21)
The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system (1989) (20)
Absorption enhancement of hydrophilic compounds by verapamil in Caco-2 cell monolayers. (1994) (20)
Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent, in mice. (1998) (20)
Single‐ and multiple‐dose nisoldipine kinetics and effects in the young, the middle‐aged, and the elderly (1989) (20)
ASSESSMENT AND PREDICTION OF IN VIVO OXIDATIVE DRUG METABOLIZING ACTIVITY (1984) (20)
Identification of cannabicyclol with a pentyl or propyl side-chain by means of combined gas chromatography-mass spectrometry. (1972) (20)
The Use of Intracerebral Microdialysis to Determine Changes in Blood-Brain Barrier Transport Characteristics (2004) (20)
Rectal infusion of the model drug antipyrine with an osmotic delivery system. (1981) (19)
Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine. (1993) (19)
Pharmacokinetics of hexobarbital in man after intravenous infusion (1975) (19)
Biotransformation of 1,2-dibromopropane in rats into four mercapturic acid derivatives. (1986) (19)
Antipyrine metabolite formation in children in the acute phase of malnutrition and after recovery. (1980) (19)
Blood-brain barrier transport rate of quinoline antibacterials evaluated in cerebrovascular endothelial cell cultures (1993) (19)
Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure (1988) (19)
Hepatic first-pass effect and controlled drug delivery following rectal administration (1997) (18)
3‐Amino‐1‐hydroxypropylidene‐1,1‐diphosphonate (APD): a novel enhancer of rectal cefoxitin absorption in rats (1989) (18)
Rationale for rate-controlled drug delivery of cardiovascular drugs by the transdermal route. (1984) (18)
Assay of flunitrazepam, temazepam and desalkylflurazepam in plasma by capillary gas chromatography with electron-capture detection. (1982) (18)
Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles. (1984) (18)
Pharmacokinetics of lidocaine and bupivacaine following subarachnoid administration in surgical patients: simultaneous investigation of absorption and disposition kinetics using stable isotopes. (1988) (18)
Pharmacokinetics and Hemodynamic Effects of Long‐Term Nifedipine Treatment in Hypertensive Patients (1987) (18)
Dose-dependent stereoselectivity in the formation of mercapturic acids from cyclohexene oxide by the rat. (1981) (18)
Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies. (1983) (18)
Gas chromatographic analysis of nitrendipine and its pyridine metabolite in human plasma. (1988) (18)
The direct mutagenic activity of α,ω-dihalogenoalkanes in Salmonella typhimurium: Strong correlation between chemical properties and mutagenic activity (1984) (18)
Pharmacodynamics of temazepam in primary insomnia: Assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep (1997) (18)
Future training needs in the pharmaceutical sciences: academia -- industry. (2001) (17)
Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a ‘cocktail’ approach (1989) (17)
Pharmacokinetics of oral brotizolam in patients with liver cirrhosis. (1983) (17)
Rate-controlled absorption enhancement of rectally administered cefoxitin in rats by salicylate (1988) (17)
Hexobarbitone disposition at different stages of intensive care treatment. (1981) (16)
Interaction between digoxin and nifedipine at steady state in patients with atrial fibrillation. (1985) (16)
1,2-Dibromo compounds. Their mutagenicity in Salmonella strains differing in glutathione content and their alkylating potential. (1987) (16)
Disposition of hexobarbital enantiomers in the rat. (1983) (16)
A computer-based international 'thesis-line'? (1995) (16)
Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration. (1979) (16)
Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver. (1974) (16)
Rectal and intravenous propranolol infusion to steady state: Kinetics and β‐receptor blockade (1984) (16)
Effects of Single‐Dose and Short‐Term Oral Nifedipine on Indocyanine Green Clearance as Assessed by Spectrophotometry and High Performance Liquid Chromatography (1990) (16)
The influence of infusion rate on the hemodynamic effects of felodipine (1990) (16)
Occurrence and inducibility of cytochrome P-450 and mixed function oxidase activities in microsomes from Drosophila melanogaster larvae (1979) (16)
Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state (1994) (16)
Nisoldipine: Kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration (2004) (16)
The Relationship between Phenazone (Antipyrine) Metabolite Formation and Theophylline Metabolism in Healthy and Frail Elderly Women (1993) (16)
Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing (1989) (15)
Stereoselectivity in the urinary excretion of the mercapturates of (R-) and (S-) alpha-bromoisovalerylurea in man. (1989) (15)
Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects. (1990) (15)
Assay of 3-carboxy-antipyrine in urine by capillary gas chromatography with nitrogen selective detection. Some preliminary results in man. (1979) (15)
Drug transport across the blood-brain barrier (1993) (15)
Differences in inducibility of particulate and cytosolic rat liver glutathione S-transferase activities. (1981) (15)
Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats. (1989) (15)
Cytosolic glutathione S-transferases in Drosophila melanogaster. (1984) (15)
Effects of Acute Febrile Infectious Diseases on the Oral Pharmacokinetics and Effects of Nitrendipine Enantiomers and of Bisoprolol (1992) (15)
Biotransformation and spectral interaction of xenobiotics with subcellular fractions from Drosophila melanogaster. (1980) (14)
Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects. (1986) (14)
Influence of Haemodialysis on the Pharmacokinetics and Haemodynamic Effects of Nifedipine During Continuous Intravenous Infusion (1986) (14)
Radioimmunoassay of desglycinamide-arginine vasopressin and its application in a pharmacokinetic study in the rat (1988) (14)
Reconstitution of the blood-brain barrier in cell culture for studies of drug transport and metabolism (1996) (13)
Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers. (1989) (13)
The glutathione S-transferases: their role in detoxification and toxification of xenobiotics. (1980) (13)
Disposition of hexobarbital: 15 years of an intriguing model substrate. (1988) (13)
Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics (2004) (13)
Influence of corticosteroid on hexobarbital and tolbutamide disposition (1978) (13)
Transport of peptide and protein drugs across biological membranes (1990) (13)
Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists (1999) (13)
(D) Routes of delivery: Case studies (1992) (13)
Zero-order release of oxprenolol-HCl, a new approach (1988) (12)
Nonlinear first-pass metabolism of nifedipine in healthy subjects. (1991) (12)
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents (2004) (12)
The contribution of nisoldipine-induced changes in liver blood flow to its pharmacokinetics after oral administration. (1989) (12)
Avoidance of “First-Pass” Elimination of Rectally Administered Propranolol in Relation to the Site of Absorption in Rats (1983) (12)
Rectal absorption enhancement of peptide drugs (1990) (12)
Absorption Enhancement of Rectally Infused Cefoxitin Sodium by Medium-Chain Fatty Acids in Conscious Rats: Concentration–Effect Relationship (1988) (12)
Transport of a Hydrophilic Compound into the Cerebrospinal Fluid During Experimental Allergic Encephalomyelitis and After Lipopolysaccharide Administration (1995) (12)
Zero-order rectal delivery of theophylline in man with an osmotic system (1982) (12)
Absorption enhancement of rectally infused cefoxitin by medium chain monoglycerides in conscious rats. (1988) (12)
Pharmacokinetics and Haemodynamic Effects of Nisoldipine in Patients with Liver Cirrhosis (1987) (11)
Gas chromatographic determination of the laxative 1, 8-dihydroxyanthraquinone in urine and faeces. (1976) (11)
Interaction Study between Org 10172, a Low Molecular Weight Heparinoid, and Acetylsalicylic Acid in Healthy Male Volunteers (1991) (10)
Influence of Heparin and a Low Molecular Weight Heparinoid on Specific Endogenous and Exogenous Fibrinolytic Factors during Rest and Exercise (1992) (10)
Pharmacokinetics and bioavailability of intravenous, oral, and rectal nitrazepam in humans (1982) (10)
Clinical pharmacokinetics of hypnotic benzodiazepines: a summary. (1983) (10)
Effect of apical and/or basolateral application of EDTA on the permeability of hydrophilic compounds in a human intestinal epithelial cell-line (Caco-2) (1992) (10)
High-performance liquid chromatographic determination of the polar metabolites of nifedipine in plasma, blood and urine. (1991) (10)
Central effects during the continuous osmotic infusion of a benzodiazepine (triazolam). (1985) (10)
Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection. (1978) (10)
Variability in the Pharmacokinetics of Nisoldipine as Caused by Differences in Liver Blood Flow Response (1989) (9)
Site Specific Rectal Drug Administration in Man with an Osmotic System: Influence on “First-Pass” Elimination of Lidocaine (1984) (9)
Pharmacokinetic‐haemodynamic relationships of 2‐chloroadenosine at adenosine A1 and A2a receptors in vivo (1996) (9)
Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry. (1981) (9)
Assay of nitrazepam and triazolam in plasma by a radioreceptor technique and comparison with a gas chromatographic method. (1982) (9)
Pharmacokinetics in liver disease (1987) (9)
Pharmacokinetics of hypnotic drugs: studies on the pharmacokinetics and biopharmaceutics of barbiturates and chloral hydrate in man (1974) (9)
Effects of intravenous temazepam. II. A study of the long‐term reproducibility of pharmacokinetics, pharmacodynamics, and concentration‐effect parameters (1994) (9)
Effect of rifampicin treatment on in vitro drug-metabolizing activities in the pig. (1984) (9)
Relative bioavailability of chloral hydrate after rectal administration of different dosage forms (1973) (9)
Characterization of glutathione conjugation in humans: Stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)‐ and (S)‐2‐bromoisovalerylurea in healthy volunteers (1993) (9)
Pharmacokinetic and pharmacodynamic basis for peptide drug delivery system design (1992) (9)
Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response Methodology (1990) (9)
Pharmacokinetics of Lidocaine and Bupivacaine following Subarachnoid Administration in Surgical Patients: Simultaneous Investigation of Absorption and Disposition Kinetics Using Stable Isotopes (1988) (9)
Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers. (1993) (8)
The influence of a standard meal on Sinemet CR absorption in patients with Parkinson's disease (1993) (8)
Hexobarbital-1',2'-epoxide: a possible intermediate in the metabolism of hexobarbital. (1978) (8)
The influence of components on the rectal absorption of cefazolin in rats (1988) (8)
Lack of pharmacokinetic interaction between nifedipine, sparteine and phenytoin in man. (1991) (8)
Route‐ and dose‐dependent pharmacokinetics of hexobarbitone in the rat: a re‐evaluation of the use of sleeping times in metabolic studies (1985) (8)
First-pass elimination of salicylamide in man following oral and rectal administration. (1983) (8)
Antipyrine metabolite formation and excretion in patients with chronic renal failure (2004) (8)
Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats. (1995) (8)
Glutathione conjugation of 1,2-dibromo-1-phenylethane in rats in vivo. (1987) (8)
Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo. (1996) (8)
Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats (1988) (8)
Assay of etomidate in plasma by capillary gas chromatography with nitrogen-selective detection. (1979) (8)
Gas chromatography of cannabinoids. Gas chromatographic behaviour of cis- and trans- tetrahydrocannabinol and isotetrahydrocannabinol. (1973) (7)
Cannabivarichromene, a new cannabinoid with a propyl side chain in cannabis (1973) (7)
Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration (1976) (7)
Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration. (1983) (7)
Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine. (1977) (7)
Genetic polymorphisms in drug metabolism: clinical implications and consequences in ADME studies (1994) (7)
Assay of underivatized salicylamide in plasma, saliva and urine. (1979) (7)
Antipyrine metabolism in patients with disseminated testicular cancer and the influence of cytostatic treatment (2004) (7)
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. (1994) (6)
Pharmacokinetics of temazepam compared with other benzodiazepine hypnotics—some clinical consequences (1986) (6)
Drug transport across the blood — brain barrier (1992) (6)
Application of pharmacokinetic/pharmacodynamic modelling and population approaches to drug development (1999) (6)
The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172. (1991) (6)
Comparative effects of felodipine, nitrendipine and nifedipine in healthy subjects: concentration-effect relationships of racemic drugs and enantiomers (2004) (6)
Metabolic Activation and Mutagenic Properties of Procarcinogens in Drosophila (1983) (6)
Selected ion monitoring analysis of pseudoracemic hexobarbital and its major metabolites in blood and urine of rats. (1985) (6)
Metabolism of simultaneously administered antipyrine and theophylline in male BN/BiRij rats before and after induction with 3-methylcholanthrene. (1992) (6)
An improved synthesis of 3-hydroxymethylantipyrine using antipyrine as starting material. (1986) (6)
Microsomal and cytosolic epoxide hydrolase in Drosophila melanogaster. (1986) (6)
An integrated pharmacokinetic and pharmacodynamic approach to controlled drug delivery. (1996) (6)
Enantioselective determination of R- and S-(alpha-bromoisovaleryl)urea in plasma using high-performance liquid chromatography after solid-phase extraction. (1992) (6)
Topics in Pharmaceutical Sciences 1985 (1986) (6)
Towards better safety of drugs and pharmaceutical products : proceedings of the 39th International Congress of Pharmaceutical Sciences of F.I.P., held in Brighton, U.K., September 3-7, 1979 (1980) (5)
The bioavailability of seven commercially available rectal aminophylline suppositories (1981) (5)
Interaction study between nifedipine and recombinant tissue-type plasminogen activator in healthy subjects. (1993) (5)
Peptide transport across the blood-brain barrier☆ (1990) (5)
Studies on the different metabolic pathways of antipyrine as a tool in the assessment of the activity of different drug metabolizing enzyme systems in man [proceedings]. (1980) (5)
Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats. (1986) (5)
Hora est! : on dissertations (2005) (5)
[Metabolism of hexobarbital in patients with acute hepatitis and cirrhosis (author's transl)]. (1977) (5)
Rate controlled rectal drug delivery in man (1985) (5)
The CED—le DEC: Common European doctorate, or doctorate Europeen commune or dissertations on the internet (1996) (5)
Gas chromatographic determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine. (1988) (5)
[Transport of drugs across the blood-brain barrier]. (1998) (5)
Dose-dependent pharmacokinetics of zoxazolamine in the rat. (1986) (5)
Influence of Chlorthalidone on the Pharmacokinetics and Pharmacodynamics of Org 10172 (Lomoparan®), A Low Molecular Weight Heparinoid, in Healthy Volunteers (1991) (5)
Urinary metabolite profile of antipyrine as a tool in the assessment of oxidative drug metabolizing capacity of man (1980) (5)
Absorption Enhancement of a Hydrophilic Model Compound by Verapamil After Rectal Administration to Rats (1995) (5)
Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt. (1984) (4)
Cannabinodiol, a new hashish consituent, identified by gaschromatography-mass spectrometry (1973) (4)
Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in Rats (1990) (4)
The use of intracerebral microdialysis to study blood-brain barrier transport in health, after modification and in disease. (1993) (4)
Drug transport to the brain: in vitro versus in vivo approaches (1994) (4)
Sleep Research (1979) (4)
Stereospecific analysis of racemic hexobarbital in rat blood by enantioselective capillary gas chromatography. (1986) (4)
Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man (1975) (4)
Improvement of drug absorption through enhancers (1990) (4)
The activating role of glutathione in the mutagenicity of 1,2-dibromoethane. (1981) (4)
ABSORPTION KINETICS OF LIDOCAINE AND BUPIVACAINE FOLLOWING EPIDURAL AND SUBARACHNOID ADMINISTRATION - A STUDY USING A STABLE ISOTOPE METHOD (1986) (4)
University—industry collaboration in the pharmaceutical sciences (1996) (4)
Pharmacology in The Netherlands: past, present and future. (2008) (4)
Clinical Pharmacokinetic and Biopharmaceutical Aspects of Hypnotic Drug Therapy (1979) (4)
Introduction to the Blood–Brain Barrier: Intracerebral microdialysis (1998) (4)
In vitro penetration of des-tyrosine1-D-phenylalanine3-β-casomorphin across the blood-brain barrier (1992) (3)
Development of specific antisera against 9-desglycinamide-8-arginine vasopressin by site-specific immunization. (1991) (3)
In Memoriam: Dr. Harry Boddé, Associate Professor, Division of Pharmaceutical Technology, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, The Netherlands (1997) (3)
GLUCURONIDE CONJUGATION AS AN ALTERNATIVE BIOTRANSFORMATION PATHWAY OF HEXOBARBITAL AND METHOHEXITAL IN RATS WITH EXPERIMENTAL HEPATITIS AND CHOLESTASIS (1982) (3)
Pharmacokinetics of butobarbital after single and multiple oral doses in man (1976) (3)
Variability in human drug metabolism and its implications. (1983) (3)
Monitoring in vivo blood-brain barrier drug transport : cerebrospinal fluid sampling, the unit impulse response method and, with special reference, intracerebral microdialysis (1997) (3)
Identification of hashish constituents by a new method of combined gas chromatography-mass spectrometry: Identification of Cannabidiol, Tetrahydrocannabinol, Cannabinol, THC and their homologues with a propyl and methyl side chain (1971) (3)
Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers (1991) (3)
Gas-liquid chromatography in pharmacology and toxicology. Pharmacokinetic analysis limited by the sensitivity of the analytical technique. (1971) (3)
Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs. (1996) (3)
Pharmacokinetics and relative bioavailability of vinylbital in man after oral and rectal administration. (1976) (3)
Implications of P–glycoprotein for the Transport and Distribution of Drugs into the Brain (2004) (3)
Rectal Absorption Enhancement of Des-Enkephalin-γ-Endorphin (DEγE) by Medium-Chain Glycerides and EDTA in Conscious Rats (2004) (3)
Correlation of apparent intrinsic clearances of simultaneously administered S (+) and d3R (-) hexobarbital in the rat. (1987) (3)
Mephenytoin polymorphism in relation to methylphenytoin phenytoin and phenobarbital hydroxylation (1987) (3)
Academic pharmaceutics: The challenge of excellence (1990) (3)
Rational Selection of Methods for Therapeutic Drug Monitoring (1979) (3)
Stereoselective pharmacokinetics of oral nitrendipine in elderly hypertensive patients with normal and impaired renal function (1992) (3)
The metabolic fate of 1',2'-epoxyhexobarbital in the rat. (1981) (2)
Interaction of the combined medication with the new low-molecular-weight heparinoid Lomoparan (Org 10172) and acenocoumarol. (1990) (2)
Abnormal glutathione conjugation in patients with tyrosinaemia type I (1997) (2)
General Pharmacokinetic Principles of Induction Agents (1981) (2)
Relative bioavailability of cyclobarbital calcium from aqueous solution compared to tablets. (1975) (2)
Rectal, oral and I.A. administration of etomidate to rats: significant avoidance of hepatic first-pass elimination following rectal administration. (1984) (2)
[Methohexital clearance in patients with acute hepatitis (author's transl)]. (1979) (2)
The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN/BiRij rat. (1995) (2)
Hemodynamic and central nervous system effects of metopralol oros and propranolol in healthy volunteers (1990) (2)
The direct mutagenic activity of alpha, omega-dihalogenoalkanes in Salmonella typhimurium. Strong correlation between chemical properties and mutagenic activity. (1984) (2)
Whose university is it (2006) (2)
Eureka! : European research universities and the challenges of the 21st century (2005) (2)
T.S. Eliot's Interpretation of F.H. Bradley (2002) (2)
Blood-brain barrier permeability and stress; a study excitotoxic stress and vasogenic edema (1996) (2)
Rectal bioavailability of lidocaine from a suppository and a slow release preparation in man (1979) (2)
Therapeutic relevance of drug assays (1979) (2)
Variable effects of laurocapram (Azone) on rectal cefoxitin absorption in rats. (1989) (2)
[The fate of drugs in the body]. (1983) (2)
CNS-related performance and haemodynamics of metoprolol-Oros and propranolol after single and 3 days dosing in healthy volunteers. (1993) (2)
Interaction of ORG 10172, a low molecular weight heparinoid, and digoxin in healthy volunteers (2004) (2)
HANS BUNDGAARD IN MEMORIAM (2004) (1)
Determination of Benzodiazepines: The Present-Day Scene (1986) (1)
De Maat der Dingen (2007) (1)
Bioactivation and inactivation of mutagens in Drosophila (1984) (1)
DETERMINATION OF THE ABSORPTION KINETICS OF LIDOCAINE AND BUPIVACAINE FOLLOWING EPIDURAL ADMINISTRATION USING A STABLE ISOTOPE METHOD (1986) (1)
Influence of complex metabolic factors on mutagenicity testing in Drosophila melanogaster (1983) (1)
Report on the workshop “molecular basis of polymorphic drug oxidation in man”, Otzenhausen, 1983 (1984) (1)
Metabolism and mutagenicity of dibromoethane and dibromomethane (1981) (1)
[Influence of rifampicin on the metabolic clearance of galactose and antipyrine as compared with hexobarbital]. (1975) (1)
IN VlVO CHARACTERIZATION AND MODULATION OF THE GLUTATHIONE/ SYSTEM IN CANCER PATIENTS* GLUTATHIONE S-TRANSFERASE (1995) (1)
The influence of age on drug metabolism: in vivo and in vitro studies (1990) (1)
Measurement of urinary metabolites of xenobiotics as a non-invasive technique in toxicology. (1982) (1)
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier Wijnholds, (2000) (1)
The influence of L-4-oxalysine on carbon tetrachloride-induced changes in drug-metabolizing enzyme activity of mouse liver. (1982) (1)
The influence of pretreatment on the urinary metabolite profile of pseudoracemic hexobarbital. (1986) (1)
Rectal absorption enhancement of des-enkephalin-gamma-endorphin (DE gamma E) by medium-chain glycerides and EDTA in conscious rats. (1989) (1)
The role of the glutathione-S-transferase in the mutagenicity of vicinal dihalogeno compounds (1981) (1)
Sensitivity of CNS performances tests to the effects of sleep deprivation (1993) (1)
Non-linear pharmacokinetics of sparteine in the rat. (1986) (1)
Influence of the rate of hepatic portal vein infusion on hexobarbital pharmacokinetics in the rat. (1988) (1)
Complete rectal absorption of theophylline in rats without absorption enhancer. (1986) (1)
The laxative action of anthracene derivatives 3. Absorption, metabolism and excretion of rhein in the rat 1 (1979) (1)
Increased gastro-intestinal absorption of hexobarbital by hydrophilization (1980) (1)
Potential of new drug delivery systems in veterinary medicine (1986) (1)
The Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood–Brain Barrier (2000) (0)
Influence of salicylate and anaesthesia on the rectal absorption of theophylline in rats (1986) (0)
The Center for Bio-Pharmaceutical Sciences: Scope and perspectives (1985) (0)
The influence off dietary restriction on P-450 mediated drug metabolism (1990) (0)
[Hypnotics and insomnia; report of a Consensus Development Conference]. (1985) (0)
Possibilities for oral peptide delivery using the mucoadhesive polymer polycarbophil (1992) (0)
Board of Pharmaceutical Sciences (2005) (0)
Age-related changes in oxidative drug metabolism versus pathological and nutritional condition and drug consumption (1991) (0)
Pronounced Effects of the Combination of a New Thromboxane Antagonist (GR32191) and Heparin on Bleeding Time in Man (1992) (0)
Elimination of drug metabolites in liver disease (1980) (0)
The Hugh Davson Memorial Lecture (1999) (0)
Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat (1986) (0)
Research in the Division of Pharmacology (1985) (0)
Volume Regulation of the in Vitro Blood-Brain Barrier by Osmoreactive Amino Acids during Stress (1996) (0)
1078 – PHARMACOKINETICS AND ANESTHETIC ACTION OF HEXOBARBITAL IN PATIENTS WITH ACUTE AND CHRONIC LIVER DISEASE (1977) (0)
Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio (1986) (0)
Topics in pharmaceutical sciences, 1983 : proceedings of the 43rd International Congress of Pharmaceutical Sciences of F.I.P., held in Montreux, Switzerland, September 5-9, 1983 (1983) (0)
Pharmaceutical stategies for improving the delivery of peptides to the brain (1990) (0)
The epoxide-diol pathway in the metabolism of vinylbital in rat and man. (1980) (0)
The influence of dietary restriction on P450-mediated drug metabolism in ageing female BN/BiRij rats (1991) (0)
Postgraduate Course on "Drug Development and Aging—From Animal Models to Therapeutic Practice," November 9-11, 1988, Leiden, The Netherlands (2008) (0)
Assay of midazolam and brotizolam in plasma by a gas chromatographic and a radioreceptor technique (1983) (0)
Inhibition of cytosolic rat hepatic glutathione S-transferase activities by bromosulfophthaleins (1982) (0)
[Racemic therapeutic agents; problems concerning medical ethics and registration]. (1991) (0)
P13 Absorption enhancement of hydrophilic compounds by racemic verapamil after rectal administration in rats (1994) (0)
Biopharmaceutical studies of fatty suspension suppositories (1979) (0)
Determination of glutathione in biological material by high pressure liquid chromatography (1983) (0)
[The effect of floctafenine (Idalon) on anticoagulant treatment with coumarin derivatives]. (1981) (0)
Factors affecting the error in the Loo-Riegelman method for estimating the rate of drug absorption. Some suggestions for a practical sampling schedule. (1983) (0)
Process Query Systems Advanced Technologies for Process Detection and Tracking (0)
Subject Index, Vol. 22, 1981 (1981) (0)
Interactions study of the low molecular weight heparinoid Org 10172 (lomoparan®) and acetylsalicylic acid in healthy male volunteers (1990) (0)
SYNTHESIS AND ACID- AND BASE-CATALYZED REACTIONS OF HEXOBARBITAL 1′,2′-EPOXIDE AND HEPTABARBITAL 1′,2′-EPOXIDE (1979) (0)
CROSSOVER STUDIES IN THE RAT WITH SIMULTANEOUSLY ADMINISTERED MODEL-DRUGS (1982) (0)
Modulators of Blood-Brain Barrier (BBB) Permeability: In Vitro and in Vivo Drug Transport to the Brain (2001) (0)
An Interview with a Distinguished Pharmaceutical Scientist: Douwe D. Breimer–Elected Foreign Associate Member of the Institute of Medicine of the National Academy of Sciences of the U.S.A. (1999) (2004) (0)
Editorial Special Supplement of the European Journal of Pharmaceutical Sciences on the occasion of the retirement of Professor Meindert Danhof as Professor of Pharmacology at Leiden University. (2017) (0)
Abstracts of papers biopharmaceutical meeting (2005) (0)
Disposition and delivery of peptide drugs, 2 : proceedings of the Second International Symposium on Recent Advances in Drug Delivery Systems (F.I.P. Satellite Symposium), Leiden, The Netherlands, September 1-3,1989 (1990) (0)
An APL computer program for estimating rate constants of drug absorption. (1983) (0)
P5 Lymphocyte adhesion to brain capillary endothelial cells in vitro (1994) (0)
INTRODUCTION. Challenges of the Twenty-first Century (2005) (0)
A Guide to Clinical Drug Research (1995) (0)
PHARMACOKINETICS AND METABOLISM OF (+)- AND (-)- HEXOBARBITAL IN RATS (1982) (0)
[Comparative pharmacokinetics of 5 hypnotic benzodiazepines in healthy volunteers]. (1982) (0)
P12 Absorption enhancement of hydrophilic compounds by verapamil in Caco-2 cell monolayers (1994) (0)
Topics in pharmaceutical sciences 1989 : proceedings of the 49th International Congress of Pharmaceutical Sciences of F.I.P., held in Munich, Germany, 4-9 September 1989 (1989) (0)
Studies onthedifferent metabolic pathways of antipyrine asatool intheassessment ofthe activity ofdifferent drugmetabolizing enzyme systems inman (1979) (0)
Surviving in a 'knowledge market' (1996) (0)
Variability in drug metabolism: importance of genetic constitution (1987) (0)
Differential sensitivity off three performance tests to the effects of temazepam in healthy volunteers (1990) (0)
Assessment ofhepatic bloodflowinhealthy subjects by continuous infusion ofindocyanine green (1991) (0)
Assay of propranolol in human and rat plasma by capillary gas chromatography with nitrogen selective detection (1980) (0)
Topics in pharmaceutical sciences, 1987 : proceedings of the 47th International Congress of Pharmaceutical Sciences of F.I.P., held in Amsterdam, the Netherlands, 31 August-4 September 1987 (1987) (0)
INDUCTION OF RAT HEPATIC GLUTATHIONE-S-TRANSFERASE ACTIVITIES BY 2,3,7,8-TETRACHLORO-DIBENZO-p-DIOXIN (1982) (0)
Effect of endotoxin on cerebral endothelial cells (1994) (0)
Involvement of glutathione and glutathione S-transferases in mutagenicity and DNA binding of 1,2-dibromoethane (1983) (0)
Board of Pharmaceutical Sciences (1979) (0)
Topics in pharmaceutical sciences, 1985 : proceedings of the 45th International Congress of Pharmaceutical Sciences of F.I.P., held in Montreal, Canada, September 2-6, 1985 (1985) (0)
Oralabsorption profile ofnitrendipine inhealthy subjects: akinetic anddynamic study (1989) (0)
Synthesis and acid‐ and base‐catalyzed reactions of hexobarbital 1′,2′‐epoxide and heptabarbital 1′,2′‐epoxide (2010) (0)
DISPOSITION OF PSEUDORACEMIC HEXOBARBITAL IN THE RAT - EFFECTS OF PRETREATMENT AND INVOLVEMENT OF CYTOCHROMES-P-450 (1984) (0)
Targeted therapeutic systems, volume 3 in the series targeted diagnosis and treatment: P. Tyle and B.P. Ram (eds.), J.D. Rodwell (series ed.), Marcel Dekker, Inc., New York, NY, 1990, xv + 388 pages, $125. U.S. and Canada, $150 outside (1990) (0)
Contents, Vol. 22, 1981 (1981) (0)
Professor Margareta Hammarlund-Udenaes - A Humble Scientist Shaping Modern Neuropharmacokinetics (2022) (0)
[Pharmacokinetics as the key to understanding drug actions]. (1996) (0)
Thecontribution ofnisoldipine-indu ced changes inliver blood flowtoits pharmacokinetics after oral administration (1989) (0)
The Relationship Between Theophylline Metabolism and Antipyrine Metabolite Formation in Healthy, Elderly People (1990) (0)
Pharmacokinetics and metabolism in drug development: current and future strategies (1998) (0)
Effects of oral nifedipine and physical exercise on liver blood flow in healthy subjects (1990) (0)
The influence of absorption promoters on the rectal mucosal integrity in rats (1990) (0)
343 – CYTOCHROME P-450 IN HUMAN PLATELETS: THE CAPACITY OF PLATELET MICROSOMES TO METABOLIZE SOME XENOBICTICS AND ARACHIDONIC ACID (1978) (0)
Monooxygenase activity of systems reconstituted with fractions from rats fed standard and low protein diets (1986) (0)
Correlation Between In Vivo Antipyrine Metabolite Formation and Theophylline Metabolism in Rats (1986) (0)
Board of Pharmaceutical Sciences (1979) (0)
Developmental aspects of hepatic glutathione S-transferase activities in male rats (1980) (0)
Letter: Pharmacokinetics of (+)-, (-)- and (plus or minus)-hexobarbitone in man after oral administration. (1973) (0)

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