Dr. Derek Leroith

Dr. Derek Leroith's AcademicInfluence.com Rankings

Dr. Derek Leroith

Biology

#3390

World Rank

#5195

Historical Rank

Endocrinology

#12

World Rank

#15

Historical Rank

Cell Biology

#71

World Rank

#75

Historical Rank

Molecular Biology

#224

World Rank

#228

Historical Rank

biology Degrees

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Biology

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Dr. Derek Leroith's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular and cellular aspects of the insulin-like growth factor I receptor. (1995) (1445)
Normal growth and development in the absence of hepatic insulin-like growth factor I. (1999) (1389)
The role of the IGF system in cancer growth and metastasis: overview and recent insights. (2007) (1011)
Skeletal muscle. (2005) (954)
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. (1999) (931)
The insulin-like growth factor system and cancer. (2003) (919)
Circulating levels of IGF-1 directly regulate bone growth and density. (2002) (897)
Insulin-like Growth Factors and Cancer (1995) (788)
Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways* (1997) (679)
American association of clinical endocrinologists and american college of endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015. (2015) (607)
Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity (2001) (553)
Diabetes mellitus : a fundamental and clinical text (2004) (523)
Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. (2015) (501)
A Molecular Basis for Insulin Resistance (1997) (430)
Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. (2002) (401)
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. (1996) (391)
Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II (1992) (377)
Insulin-like growth factor I is required for vessel remodeling in the adult brain. (2004) (371)
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo (2004) (359)
Developmental regulation of the rat insulin-like growth factor I receptor gene. (1989) (336)
Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. (1990) (329)
Minireview: IGF, Insulin, and Cancer. (2011) (327)
The role of the insulin-like growth factor system in human cancer. (1996) (322)
The proliferating role of insulin and insulin-like growth factors in cancer (2010) (312)
Serum insulin-like growth factor I regulates brain amyloid-β levels (2002) (297)
Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I. (1987) (293)
Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1 (2007) (290)
The worldwide diabetes epidemic (2012) (288)
The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. (2008) (284)
Biological effects of growth hormone on carbohydrate and lipid metabolism. (2010) (282)
Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues. (1987) (275)
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. (1993) (270)
Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. (1998) (264)
Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. (2010) (257)
The Link between the Metabolic Syndrome and Cancer (2011) (253)
Serum insulin-like growth factor I regulates brain amyloid-beta levels. (2002) (253)
Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. (2012) (248)
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS. (2016) (246)
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. (2004) (240)
Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. (1999) (239)
The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts* (1997) (237)
Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding. (1989) (237)
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). (1993) (232)
Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction (2004) (231)
Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. (2002) (231)
Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline. (2019) (230)
Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver. (1988) (226)
Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology. (2001) (224)
The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology. (1982) (222)
Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. (1996) (221)
Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. (1997) (221)
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. (2009) (216)
Insulin resistance as the underlying cause for the metabolic syndrome. (2007) (214)
Insulin-like Growth Factor-I Rapidly Activates Multiple Signal Transduction Pathways in Cultured Rat Cardiac Myocytes* (1997) (213)
Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) by Protein Kinase B Positively Regulates IRS-1 Function* (1999) (208)
Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. (2003) (206)
Insulin resistance in obesity as the underlying cause for the metabolic syndrome. (2010) (204)
The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. (2005) (202)
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. (2008) (200)
Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects (2007) (195)
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. (2006) (190)
Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries. (1994) (189)
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications (2016) (188)
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. (2001) (188)
Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. (1998) (188)
Insulin-like Growth Factors: Molecular and Cellular Aspects (1991) (185)
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. (2003) (182)
Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture. (1987) (181)
Diabetes, cancer, and metformin: connections of metabolism and cell proliferation (2011) (180)
Growth hormone treatment induces mammary gland hyperplasia in aging primates (1997) (177)
Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool (2019) (176)
Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary. (1993) (173)
Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society. (2001) (171)
Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. (2009) (171)
Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary. (1992) (166)
Insulin-like Growth Factors in Health and Disease (1992) (165)
The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components* (2000) (162)
Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site. (1994) (162)
Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5'-untranslated mRNA variant representation and hormonal regulation. (1989) (160)
Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line (1994) (160)
p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. (1998) (155)
Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive. (2013) (152)
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells (2004) (150)
Obesity, Energy Balance, and Cancer: New Opportunities for Prevention (2012) (149)
Corticotropin and β-endorphin-like materials are native to unicellular organisms (1982) (149)
Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess* (2005) (148)
Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain. (1991) (148)
Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. (2006) (146)
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats. (1994) (145)
Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid. (1995) (144)
Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. (2004) (143)
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. (1997) (143)
Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes. (1991) (142)
Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome. (2002) (141)
The metabolic syndrome--from insulin resistance to obesity and diabetes. (2011) (140)
Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product. (1997) (139)
Personalized Management of Hyperglycemia in Type 2 Diabetes (2013) (139)
Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy. (2016) (134)
Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects (2014) (133)
Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. (1994) (131)
Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product. (1997) (131)
Update on diabetes mellitus: prevention, treatment, and association with oral diseases. (2008) (128)
Experimental Diabetes Increases Insulinlike Growth Factor I and II Receptor Concentration and Gene Expression in Kidney (1990) (127)
Insulin-Like Growth Factor 1 Receptor Signaling Regulates Skin Development and Inhibits Skin Keratinocyte Differentiation (2006) (127)
Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. (1989) (126)
The Intricate Role of Growth Hormone in Metabolism (2011) (126)
Epidemiology and Molecular Mechanisms Tying Obesity, Diabetes, and the Metabolic Syndrome With Cancer (2013) (125)
Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges? (2014) (125)
Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence. (2008) (124)
Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors (1997) (123)
Survival of patients with stage IV lung cancer with diabetes treated with metformin. (2015) (123)
Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression (1995) (122)
Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat. (1989) (122)
Development of brain insulin receptors: structural and functional studies of insulin receptors from whole brain and primary cell cultures. (1986) (120)
Insulin or a closely related molecule is native to Escherichia coli. (1981) (119)
Retinoid modulation of insulin-like growth factor-binding proteins and inhibition of breast carcinoma proliferation. (1991) (118)
Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia (2017) (117)
Serine Phosphorylation Proximal to Its Phosphotyrosine Binding Domain Inhibits Insulin Receptor Substrate 1 Function and Promotes Insulin Resistance (2004) (117)
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers. (1992) (116)
Insulin-like Growth Factor I Induces MDM2-dependent Degradation of p53 via the p38 MAPK Pathway in Response to DNA Damage* (2002) (115)
The Role of Endocrine Insulin-Like Growth Factor-I and Insulin in Breast Cancer (2008) (114)
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model (2013) (114)
Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene. (1994) (114)
The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor (1992) (113)
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. (2012) (112)
Editorial: Insulin-Like Growth Factor I Receptor Signaling-Overlapping or Redundant Pathways? (2000) (111)
Insulin-like Growth Factor 1 (IGF-1)-induced Twist Expression Is Involved in the Anti-apoptotic Effects of the IGF-1 Receptor* (2001) (110)
Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic Fibroblastic Growth Factor* (1997) (109)
The Role of the Tyrosine Kinase Domain of the Insulin-like Growth Factor-I Receptor in Intracellular Signaling, Cellular Proliferation, and Tumorigenesis (*) (1995) (109)
Insulin-like Growth Factor-I Stimulates Tyrosine Phosphorylation of Endogenous c-Crk (*) (1995) (109)
Diabetes, Obesity, and Breast Cancer. (2018) (108)
Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells. (1987) (107)
Insulin and insulin-like growth factor receptors in the nervous system (2008) (106)
Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes. (1989) (106)
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. (2005) (105)
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism (2009) (104)
Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis. (2001) (102)
Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death (2001) (102)
Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. (1992) (100)
Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states (1991) (99)
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line. (1992) (98)
The IGF-I Receptor Gene Promoter Is a Molecular Target for the Ewing's Sarcoma-Wilms' Tumor 1 Fusion Protein* (1996) (98)
A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization. (2007) (98)
Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins. (1997) (97)
Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance. (2003) (97)
Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome. (2003) (97)
Insulin‐like Growth Factors (1993) (97)
Insulin in Insects and Annelids (1981) (97)
Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes–Mediated Mammary Tumor Progression (2009) (95)
The new kid on the block(ade) of the IGF-1 receptor. (2004) (95)
Effect of training and growth hormone suppression on insulin-like growth factor I mRNA in young rats. (1994) (94)
Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites. (1991) (92)
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. (2002) (92)
Metabolic memory in diabetes–focus on insulin (2005) (92)
Identification of multiple transcription start sites in the human insulin-like growth factor-I gene (1991) (90)
Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene. (1990) (89)
Insulin-like Growth Factor-I (IGF-I) Receptor Activation Rescues UV-damaged Cells through a p38 Signaling Pathway (2001) (88)
Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo. (2005) (88)
The inhibition of insulin action and glucose metabolism by porcine growth hormone in porcine adipocytes is not the result of any decrease in insulin binding or insulin receptor kinase activity. (1990) (88)
Analysis of the human type I insulin-like growth factor receptor promoter region. (1991) (86)
Renal tubulointerstitial injury from ureteral obstruction in the neonatal rat is attenuated by IGF-1. (2000) (86)
Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system. (2000) (85)
The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. (2006) (85)
The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer (2015) (84)
The Role of the Insulin‐like Growth Factor‐I Receptor in Cancer (1995) (84)
Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. (2011) (83)
Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture. (1988) (83)
Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. (1995) (83)
Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes. (2004) (82)
Role of growth hormone (GH) in liver regeneration. (2004) (82)
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK). (1998) (82)
REVIEW Insulin-like growth factors: the ovarian connection (1991) (82)
Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. (1995) (81)
Insulin-like growth factor I (IGF-I): A molecular basis for endocrine versus local action? (1991) (81)
Insulin and IGFs in Obesity-Related Breast Cancer (2013) (81)
The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS (1996) (80)
Molecular and cellular aspects of insulin-like growth factor action. (1994) (80)
Developmental regulation of rat brain/Hep G2 glucose transporter gene expression. (1989) (80)
Diabetes and cancer--an AACE/ACE consensus statement. (2013) (79)
Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice. (2009) (79)
Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes (2012) (79)
Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol. (1995) (79)
Type 2 diabetes and cancer: what is the connection? (2010) (79)
Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element. (1995) (77)
Structure, expression, and regulation of the IGF-I gene. (1993) (77)
Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene. (1993) (77)
The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. (1996) (77)
Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth. (2000) (76)
Rat IGF-I cDNA's contain multiple 5'-untranslated regions. (1987) (76)
Role of the IGF-I receptor in mutagenesis and tumor promotion. (1997) (76)
Hyperinsulinaemia in cancer (2020) (76)
The metabolic syndrome--from insulin resistance to obesity and diabetes. (2008) (75)
Clinical relevance of systemic and local IGF-I: lessons from animal models. (2008) (74)
Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia (2011) (73)
Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. (2009) (73)
Insulin-like growth factor I receptor signaling--overlapping or redundant pathways? (2000) (73)
Insulin-like growth factor receptors and binding proteins. (1996) (72)
Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides. (1995) (72)
Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney. (1992) (72)
Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. (2008) (72)
Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo. (1991) (72)
Insulin‐like Growth Factor Receptors: Implications for Nervous System Function (1993) (71)
Metabolic clearance and plasma half disappearance time of exogenous gonadotropin releasing hormone in normal subjects and in patients with liver disease and chronic renal failure. (1977) (71)
TDAG51 Mediates the Effects of Insulin-like Growth Factor I (IGF-I) on Cell Survival* (2004) (71)
High-Efficient FLPo Deleter Mice in C57BL/6J Background (2009) (71)
Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. (2004) (71)
Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression. (1998) (71)
Insulin, Insulin Resistance, Obesity, and Cancer (2010) (70)
Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration (2011) (68)
Regulation of insulin‐like growth factor‐binding‐protein‐1, 2, 3, 4, 5, and 6: Synthesis, secretion, and gene expression in estrogen receptor‐negative human breast carcinoma cells (1993) (67)
High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model (2016) (66)
Coordinate Decrease of Tissue Insulinlike Growth Factor I Posttranscriptional Alternative mRNA Transcripts in Diabetes Mellitus (1989) (66)
Trajectories in Glycemic Control over Time Are Associated with Cognitive Performance in Elderly Subjects with Type 2 Diabetes (2014) (66)
Changes in Facilitative Glucose Transporter Messenger Ribonucleic Acid Levels in the Diabetic Rat Kidney. (1997) (65)
Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes (2006) (64)
Two Closely Related Human Members of Chitinase-like Family, CHI3L1 and CHI3L2, Activate ERK1/2 in 293 and U373 Cells but Have the Different Influence on Cell Proliferation (2011) (64)
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. (2004) (63)
Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum (2008) (63)
Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor. (1996) (63)
The regulation of IGF-I receptor gene expression. (1995) (63)
Highly specific role of the insulin receptor in breast cancer progression. (2015) (63)
Beyond Metformin: Safety Considerations in the Decision-Making Process for Selecting a Second Medication for Type 2 Diabetes Management (2014) (63)
Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approach (1993) (62)
Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors. (1993) (61)
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY--CLINICAL PRACTICE GUIDELINES FOR DEVELOPING A DIABETES MELLITUS COMPREHENSIVE CARE PLAN--2015--EXECUTIVE SUMMARY. (2015) (61)
Monitoring glycemic control: the cornerstone of diabetes care. (2005) (61)
Dysregulation of IGF-I signaling in uterine leiomyoma. (2002) (61)
Advances in molecular and cellular endocrinology (1997) (60)
The role of insulin receptor signaling in zebrafish embryogenesis. (2008) (60)
Determining Mammosphere-Forming Potential: Application of the Limiting Dilution Analysis (2012) (60)
Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor. (1990) (60)
Membrane-associated Insulin-like Growth Factor-binding Protein-3 Inhibits Insulin-like Growth Factor-I-induced Insulin-like Growth Factor-I Receptor Signaling in Ishikawa Endometrial Cancer Cells* (1997) (60)
Insulin Receptor Substrate-4 Enhances Insulin-like Growth Factor-I-induced Cell Proliferation* (1999) (60)
Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression. (2003) (60)
Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells. (1992) (60)
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. (2004) (59)
Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors. (1991) (59)
The epidemiology and molecular mechanisms linking obesity, diabetes, and cancer. (2013) (59)
Insulin receptors of chicken liver and brain (1986) (58)
Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor (2013) (58)
Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP System (2000) (58)
Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels. (1993) (58)
Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. (1994) (58)
Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins. (1996) (58)
Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. (2008) (57)
Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum. (1991) (57)
Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development. (2006) (56)
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats. (1993) (56)
Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro. (1990) (55)
Expression of a kinase‐deficient IGF‐I‐R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF‐I‐R (1998) (55)
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. (2006) (55)
Interaction between the Insulin Receptor and Its Downstream Effectors (1996) (55)
Insulin-related material in microbes: similarities and differences from mammalian insulins. (1985) (55)
Pathophysiology of the Metabolic Syndrome: Implications for the Cardiometabolic Risks Associated With Type 2 Diabetes (2012) (54)
The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis. (1990) (54)
The pathway from diabetes and obesity to cancer, on the route to targeted therapy. (2010) (54)
Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat. (1994) (53)
The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting (2005) (53)
Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid. (1989) (53)
Retinal insulin receptors: localization using a polyclonal anti-insulin receptor antibody (1988) (53)
Relaxin extracted from protozoa (Tetrahymena pyriformis). Molecular and immunologic properties. (1983) (53)
Clinical relevance of systemic and local IGF-I. (2005) (52)
Insulin-like growth factors. (1992) (52)
Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA. (1995) (51)
Mouse models created to study the pathophysiology of Type 2 diabetes. (2006) (51)
Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. (2013) (51)
Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice. (2006) (50)
Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. (2006) (50)
Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan. (1982) (50)
Developmental regulation of somatostatin gene expression in the brain is region specific. (1987) (50)
Molecular Biology of Diabetes (1994) (50)
Insulin receptors in the peripheral nervous system: a structural and functional analysis (1987) (50)
Diabetes, antihyperglycemic medications and cancer risk: smoke or fire? (2013) (49)
Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors (1989) (49)
Diabetes and fragility fractures - a burgeoning epidemic? (2008) (49)
Current Directions in Insulin-Like Growth Factor Research (2013) (49)
Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: hormonal regulation and receptor distribution. (1990) (49)
The Cyclin-dependent Kinase Inhibitor p21CIP/WAF Is a Positive Regulator of Insulin-like Growth Factor I-induced Cell Proliferation in MCF-7 Human Breast Cancer Cells* (2003) (48)
The association of duration of type 2 diabetes with cognitive performance is modulated by long-term glycemic control. (2014) (48)
The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary αT3 Cells by Protein Kinase Cα-mediated Negative Regulation of Akt* (2004) (48)
Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two beta subunits are derived from differences in glycosylation. (1988) (47)
Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways (2016) (47)
Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. (2004) (47)
Structure of the chum salmon insulin-like growth factor I gene. (1993) (46)
Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75 (1993) (46)
Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes (2008) (46)
Knock your SOCS off! (2005) (46)
Insulin receptors from guinea pig liver and brain: structural and functional studies. (1986) (46)
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice. (1995) (45)
Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms (2011) (45)
How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor? (1994) (45)
Impaired prolactin response to thyrotropin-releasing hormone in isolated gonadotropin deficiency and exaggerated response in primary testicular failure. (1979) (45)
How distinct are the insulin and insulin-like growth factor I signalling systems? (1992) (44)
Protection against hypoxic–ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain (2004) (44)
Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals. (1997) (44)
Evolutionary aspects of the endocrine and nervous systems. (1986) (44)
The Israel Diabetes and Cognitive Decline (IDCD) study: Design and baseline characteristics (2014) (44)
Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells. (1995) (44)
IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma. (1992) (43)
Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains (1991) (43)
Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats. (1992) (43)
Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer. (2013) (43)
Insulin-like growth factors: the ovarian connection. (1991) (43)
Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes. (2000) (43)
Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations. (1992) (43)
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors (2012) (43)
The intra-ovarian IGF system. (1992) (42)
Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective. (1989) (42)
Fasting and refeeding alter the insulin receptor tyrosine kinase in chicken liver but fail to affect brain insulin receptors. (1986) (42)
Obesity, Type 2 Diabetes, and Cancer Risk (2021) (42)
Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: studies using the liver-specific IGF-I gene-deleted mouse model. (2002) (42)
Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models. (2005) (42)
Replacement of Tyrosine 1251 in the Carboxyl Terminus of the Insulin-like Growth Factor-I Receptor Disrupts the Actin Cytoskeleton and Inhibits Proliferation and Anchorage-independent Growth* (1998) (42)
Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers (1993) (41)
Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary. (1992) (41)
The role of growth hormone, insulin-like growth factors (IGFs), and IGF-binding proteins in experimental diabetic kidney disease. (1995) (41)
Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats. (1992) (41)
Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit. (1997) (41)
MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness. (2006) (41)
Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid. (1992) (41)
Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis. (1997) (40)
The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor* (1997) (39)
In vitro and in vivo responses to short‐term recombinant human insulin‐like growth factor‐1 (IGF‐I) in a severely growth‐retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene (1999) (39)
Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor. (1998) (39)
14-3-3σ Mediation of Cell Cycle Progression Is p53-independent in Response to Insulin-like Growth Factor-I Receptor Activation* (2004) (38)
Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation. (1994) (38)
TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding. (1989) (38)
Rationale and Strategies for Early Detection and Management of Diabetic Kidney Disease (2008) (38)
Retinal insulin receptors. 2. Characterization and insulin-induced tyrosine kinase activity in bovine retinal rod outer segments. (1987) (38)
Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes. (1991) (38)
Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes (2004) (38)
Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes. (2010) (37)
Insulin Receptor Substrate-1 Pleckstrin Homology and Phosphotyrosine-binding Domains Are Both Involved in Plasma Membrane Targeting* (2001) (37)
Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. (1994) (37)
Interplay of the Proto-oncogene Proteins CrkL and CrkII in Insulin-like Growth Factor-I Receptor-mediated Signal Transduction* (1998) (37)
Mutation of a Conserved Amino Acid Residue (Tryptophan 1173) in the Tyrosine Kinase Domain of the IGF-I Receptor Abolishes Autophosphorylation but Does Not Eliminate Biologic Function (*) (1995) (37)
Bacillus subtilis contains multiple forms of somatostatin-like material. (1985) (37)
Insulin-like growth factors: Ligands, binding proteins, and receptors (2021) (37)
Characterization of the Mouse Sulfonylurea Receptor 1 Promoter and Its Regulation* (1999) (37)
Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Crk* (1997) (36)
The GH/IGF-1 axis in growth and development: new insights derived from animal models. (2010) (36)
Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species. (1991) (36)
Impaired muscle regeneration and myoblast differentiation in mice with a muscle‐specific KO of IGF‐IR (2010) (36)
Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity. (2012) (36)
Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats. (1991) (35)
Elevated circulating IGF-I promotes mammary gland development and proliferation. (2010) (35)
Insulin receptors in the brain: Structural and physiological characterization (1988) (35)
Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells. (1993) (35)
Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5'-untranslated regions are expressed in a tissue-specific manner. (1995) (35)
Principles of Endocrinology and Hormone Action (2018) (35)
The Role of Insulin-Like Growth Factors in the Nervous System (1993) (34)
Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat. (1992) (34)
Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System (1987) (34)
Retinal insulin receptors. 1. Structural heterogeneity and functional characterization. (1987) (34)
Hyperinsulinemia and type 2 diabetes: Impact on cancer (2010) (34)
Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes (2006) (34)
Cytokines and growth factors modulate cell growth and insulin‐like growth factor binding protein secretion by the human salivary cell line (HSG) (1995) (34)
Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens. (1996) (34)
Evolutionary origins of neuropeptides, hormones, and receptors: possible applications to immunology. (1985) (33)
NIH conference. Insulin-like growth factors in health and disease. (1992) (33)
Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats. (1994) (33)
Functional insulin-like growth factor I receptors are expressed by neural-derived continuous cell lines. (1988) (33)
Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid. (1993) (32)
13 – Insulin-Like Growth Factors in the Brain (1993) (32)
Gestational Diabetes Mellitus in HIV-Infected and -Uninfected Pregnant Women in Cameroon (2013) (31)
The effect of clomiphene citrate on pubertal gynaecomastia. (1980) (31)
Molecular and cellular biology of diabetes mellitus (1989) (31)
Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus. (2004) (31)
IGF-I Receptor Function (1999) (31)
Insulin-like growth factor-I: compartmentalization within the somatotropic axis? (2002) (31)
IGF1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors. (2014) (31)
Is growth hormone resistance/IGF-1 reduction good for you? (2011) (30)
Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus. (2014) (29)
Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines. (2008) (29)
Silencing Vimentin Expression Decreases Pulmonary Metastases in a Pre-Diabetic Mouse Model of Mammary Tumor Progression (2016) (29)
Lower mitochondrial DNA and altered mitochondrial fuel metabolism in HIV-exposed uninfected infants in Cameroon (2017) (29)
The effect of dipeptidyl peptidase‐IV inhibition on bone in a mouse model of type 2 diabetes (2014) (29)
Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model. (2013) (28)
Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells. (1989) (28)
Insulin‐like Growth Factor I as an Intraovarian Regulator: Basic and Clinical Implications a (1991) (28)
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth. (1994) (28)
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment (2018) (28)
In Vivo Regulation of CrkII and CrkL Proto-oncogenes in the Uterus by Insulin-like Growth Factor-I (1997) (28)
Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat (1996) (27)
Regulation of rat brain/HepG2 glucose transporter gene expression by phorbol esters in primary cultures of neuronal and astrocytic glial cells. (1990) (27)
Two insulin genes are present in the salmon genome. (1993) (27)
Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells. (1993) (27)
MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity (2010) (27)
Metabolic effects of IGF-I deficiency: lessons from mouse models. (2005) (27)
Molecules of intercellular communication in vertebrates, invertebrates and microbes: do they share common origins? (1986) (27)
Induction of Renal Kallikrein and Renin Gene Expression by Insulin and IGF-I in the Diabetic Rat (1997) (26)
CrkII Participation in the Cellular Effects of Growth Hormone and Insulin-like Growth Factor-1 (2000) (26)
Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2. (2011) (26)
Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes (2017) (26)
Characterization of the chicken muscle insulin receptor. (1987) (26)
Tyrosine kinase activity of brain insulin and IGF-1 receptors. (1986) (25)
The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration. (1992) (25)
Diabetes cure--is the glass half full? (2006) (25)
CD24+ cells fuel rapid tumor growth and display high metastatic capacity (2015) (25)
Insulin-related materials in the nervous system of vertebrates and non-vertebrates: possible extrapancreatic production. (1988) (25)
Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence. (1993) (25)
Insulin resistance contributes to racial disparities in breast cancer prognosis in US women (2020) (24)
Skeletal Muscle Growth Hormone Receptor Signaling Regulates Basal, but Not Fasting-Induced, Lipid Oxidation (2012) (24)
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression (1994) (24)
Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis. (2004) (24)
Corticotropin and beta-endorphin-like materials are native to unicellular organisms. (1982) (24)
Deletion of growth hormone receptors in postnatal skeletal muscle of male mice does not alter muscle mass and response to pathological injury. (2013) (24)
The Evolutionary Origins of Intercellular Communication and the Maginot Lines of the Mind (1986) (24)
EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice. (2016) (23)
Insulin-Like Growth Factors and Their Receptors in Normal Physiology and Pathological States (1993) (23)
Rationale and strategies for early detection and management of diabetic kidney disease. (2008) (23)
The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action. (2003) (23)
Dyslipidemia and glucose dysregulation in overweight and obese patients. (2007) (23)
The benefits of tight glycemic control in type 2 diabetes mellitus. (2007) (23)
Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus (2009) (23)
Development of brain insulin receptors. (1988) (23)
Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis. (1995) (23)
The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors. (1993) (22)
The role of insulin-like growth factors in diabetic kidney disease. (1993) (22)
Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim (2012) (22)
Salmon calcitonin-like immunoactivity in extracts of Tetrahymena pyriformis. (1985) (21)
Somatostatin-like material is present in flowering plants. (1985) (21)
Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon. (2015) (21)
Effect of Case-Based Training for Medical Residents on Inpatient Glycemia (2011) (21)
Endogenous plasma growth hormone and the occurrence of pregnancies in patients undergoing in-vitro fertilization and embryo transfer with ovarian stimulation. (1995) (21)
Prediabetes and diabetes among HIV‐infected adults in Cameroon (2016) (21)
Dissociation of pituitary glycoprotein response to releasing hormones in chronic renal failure. (1980) (21)
Getting to the “Heart” of the Matter on Diabetic Cardiovascular Disease: “Thanks for the Memory” (2016) (20)
Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states. (1991) (20)
Insulin-sensitive tyrosine kinase is increased in livers of adult obese Zucker rats: correction with prolonged fasting. (1988) (20)
Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus. (1998) (20)
Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism. (1994) (20)
The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes (2011) (20)
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation (2009) (20)
Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse. (2004) (20)
Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. (2008) (20)
Changes in facilitative glucose transporter messenger ribonucleic acid levels in the diabetic rat kidney. (1997) (19)
Molecular aspects of insulin-like growth factors, their binding proteins and receptors. (1988) (19)
Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models (2010) (19)
Paradoxical biological effects of overexpressed insulin‐like growth factor‐1 receptors in chinese hamster ovary cells (1993) (19)
Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms. (2015) (19)
The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms (2010) (19)
Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man. (1986) (19)
Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women (2016) (18)
Short-term effects of growth hormone and insulin-like growth factor I on cancellous bone in rhesus macaque monkeys. (1997) (18)
Characterization of a salmon insulin-like growth factor I promoter. (1994) (18)
Polyol accumulation in muscle and liver in a mouse model of type 2 diabetes. (2016) (18)
The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II. (2001) (18)
Effect of Case-Based Training for Medical Residents on Confidence, Knowledge, and Management of Inpatient Glycemia (2011) (18)
Evolutionary origins of vertebrate hormones: material very similar to adrenocorticotropic hormone, beta-endorphin, and dynorphin in protozoa. (1981) (18)
Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells (1988) (18)
Exaggerated prolactin response to thyrotropin-releasing hormone and metoclopramide in primary testicular failure. (1980) (18)
Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin‐like growth factor I (2009) (17)
Betazole-induced GIP secretion is not mediated by gastric HCl. (1982) (17)
Effect of altered nutritional states on insulin receptors. (1988) (17)
Durability of the effect of online diabetes training for medical residents on knowledge, confidence, and inpatient glycemia (2012) (17)
Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer (2018) (17)
T cell receptor-induced activation and apoptosis in cycling human T cells occur throughout the cell cycle. (1999) (17)
Atropine suppression of basal and metoclopramide-induced human pancreatic polypeptide secretion in man. (1979) (17)
Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1. (1996) (16)
Components of the IGF system mediate the opposing effects of tamoxifen on endometrial and breast cancer cell growth. (1995) (16)
Effect of online diabetes training for hospitalists on inpatient glycaemia (2013) (16)
Growth hormone receptor signaling is dispensable for HSC function and aging. (2014) (16)
Regulation of insulin-like growth factor I receptor gene expression by the wilms’ tumor supressor WT1 (2007) (16)
New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut (2017) (16)
Temporal changes in insulin-like growth factor I, c-fos, and c-jun gene expression during hyperplastic kidney growth in weanling rats. (1996) (16)
Haptoglobin genotype modulates the relationships of glycaemic control with cognitive function in elderly individuals with type 2 diabetes (2015) (16)
The Tyrosine Kinase Activity of the Chicken Insulin Receptor Is Similar to That of the Human Insulin Receptor (2000) (16)
Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells. (1992) (15)
Evidence for multiple molecular weight forms of somatostatin-like material in Escherichia coli. (1985) (15)
Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways (2013) (15)
NIC5-15 as a treatment for Alzheimer's: Safety, pharmacokinetics and clinical variables (2009) (15)
The Ovarian and Testicular IGF-I System: A Comparative Analysis (1992) (15)
Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture (1989) (14)
Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes (2015) (14)
Developmental and Tissue-Specific Sulfonylurea Receptor Gene Expression. (1997) (14)
Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin. (2012) (14)
Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line. (1989) (14)
Shorter adult height is associated with poorer cognitive performance in elderly men with type II diabetes. (2015) (14)
Pituitary disorders. (2015) (14)
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats. (1994) (14)
Non-islet cell hypoglycemia. (2004) (14)
Multi-Tissue Computational Modeling Analyzes Pathophysiology of Type 2 Diabetes in MKR Mice (2014) (14)
Liver insulin receptor tyrosine kinase activity in a rat model of type II diabetes mellitus and obesity. (1989) (13)
Dissociation of prolactin response to thyrotropin-releasing hormone and metoclopramide in chronic renal failure. (1979) (13)
The Potentiation of Estrogen on IGF-I Action in MCF-7 Human Breast Cancer Cells includes Cell Cycle Components (2000) (13)
Acid-induced gastric inhibitory polypeptide secretion in man. (1980) (13)
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis (2019) (13)
The exaggerated prolactin response to thyrotropin-releasing hormone and metoclopramide in 1,2-dibromo-3-chloropropane-induced azoospermia. (1981) (13)
The TSH response to TRH is exaggerated in primary testicular failure and normal in the male castrate. (1981) (13)
Hyperglycemia, Hypertension, and Dyslipidemia in Type 2 Diabetes Mellitus: Goals for Diabetes Management (2008) (13)
Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer’s Disease (2019) (13)
Hyperinsulinemia Promotes Esophageal Cancer Development in a Surgically-Induced Duodeno-Esophageal Reflux Murine Model (2018) (13)
OP449 inhibits breast cancer growth without adverse metabolic effects. (2017) (13)
Insulin-like growth factors and the brain. (2008) (12)
The hypothalamic-pituitary axis in diabetes mellitus. (1980) (12)
Clomiphene attenuates the exaggerated prolactin response to thyrotropin-releasing hormone and metoclopramide occurring in primary testicular failure. (1981) (12)
Failure of metoclopramide to influence LH, FSH and TSH secretion or their responses to releasing hormones. (1979) (12)
Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice. (2015) (12)
Insulin Stimulates PKCζ-mediated Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) (2001) (12)
Rhythms in urine flow are not correlated with rhythmic secretion of antidiuretic hormone (ADH) in well hydrated men. (1980) (12)
Depressive Symptoms Are Associated with Cognitive Function in the Elderly with Type 2 Diabetes (2018) (11)
Regulation of the splenic somatotropic axis by dietary protein and insulin-like growth factor-I in the rat. (2003) (11)
Extracts of protozoa contain materials that react specifically in the immunoassay for guinea pig insulin. (1986) (11)
Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture (2008) (11)
Developmental and tissue-specific sulfonylurea receptor gene expression. (1997) (11)
TCR stimulation protects CD8+ T cells from CD95 mediated apoptosis. (2001) (11)
Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes (2020) (11)
Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors. (1987) (11)
Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells (2019) (11)
Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. (2018) (11)
Developmental Regulation of the Insulin and Insulin-Like Growth Factor Receptors in the Central Nervous System (1993) (11)
Insulin receptors of chicken liver and brain. Characterization of alpha and beta subunit properties. (1986) (11)
Insulin’s Role in Diabetes Management: After 90 Years, Still Considered the Essential “Black Dress” (2015) (10)
Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth (2017) (10)
Retinoic acid inhibits growth of breast cancer cell lines: the role of insulin-like growth factor binding proteins. (1993) (10)
Isolated ACTH deficiency and primary hypothyroidism: volume-dependent elevation of antidiuretic hormone secretion in the presence of hyponatremia. (1980) (10)
Metabolic syndrome and pre‐diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways (2016) (10)
Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain. (1987) (10)
Gender differences in metabolic disorders. (2009) (10)
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness. (2019) (10)
Growth Hormone Stimulates the Formation of a Multiprotein Signaling Complex Involving p130Cas and CrkII (1998) (10)
Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen (1994) (10)
Hypothalamic-pituitary function in the Bardet-Biedl syndrome. (1980) (10)
The effect of acute insulin-like growth factor-II administration on glucose metabolism in the rat. (1998) (10)
Type 2 diabetes: the role of basal insulin therapy. (2004) (10)
THE MIDLIFE TRANSITION AND THE RISK OF CARDIOVASCULAR DISEASE AND CANCER I: MAGNITUDE AND MECHANISMS. (2020) (9)
The interaction of brain insulin receptors with wheat germ agglutinin (1987) (9)
Erratum: The new kid on the block(ade) of the IGF-1 receptor (Cancer Cell 5 (201-202, 231-239)) (2004) (9)
Receptors for intercellular messenger molecules in microbes: Similarities to vertebrate receptors and possible implications for diseases in man (1986) (9)
PROLACTIN RESPONSE TO METOCLOPRAMIDE AND CHLORPROMAZINE IN PRIMARY TESTICULAR FAILURE AND ISOLATED GONADOTROPHIN DEFICIENCY (1981) (9)
Age Modulates the Association of Caffeine Intake With Cognition and With Gray Matter in Elderly Diabetics. (2018) (9)
Obesity, Type 2 Diabetes and Cancer (2012) (9)
Hodgkin lymphoma in temporal association with growth hormone replacement. (2005) (8)
Evolution of Insulin and Insulin Receptors (1987) (8)
Overcoming challenges in Type 2 diabetes management to improve patient outcomes (2010) (8)
Extraction of insulin-related material and other peptide hormones from Tetrahymena pyriformis (1985) (8)
Hormone Signaling (2002) (8)
The beneficial effect of growth hormone treatment on islet mass in streptozotocin‐treated mice (2015) (8)
Obesity, Type 2 Diabetes, and Cancer: The Insulin and Insulin-Like Growth Factor Connection (2011) (8)
A double‐blind placebo‐controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design (2020) (8)
The carboxyl‐terminal domain of insulin‐like growth factor‐I receptor interacts with the insulin receptor and activates its protein tyrosine kinase (1998) (8)
Intraovarian IGF-I System (1991) (8)
The Cyclin-dependent Kinase Inhibitor p 21 CIP / WAF Is a Positive Regulator of Insulin-like Growth Factor I-induced Cell Proliferation in MCF-7 Human Breast Cancer Cells * (2003) (8)
Insulin-like growth factors and cance (2013) (7)
Diabetes, glucose control, glucose lowering medications, and cancer risk: A 10-year population-based historical cohort (2012) (7)
Insulin action, effects on gene expression and regulation, and glucose transport (1994) (7)
Bone densitometry of the femoral midshaft in the protein-deprived rat. (1973) (7)
Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats. (1995) (7)
Interactions in the Insulin-Like Growth Factor Signaling System (1992) (7)
Treatment of diabetes: a clinical update on insulin trials. (2007) (7)
Renal function during treatment of inappropriate secretion of antidiuretic hormone with demeclocycline. (1978) (7)
Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin‐Resistant Male MKR Mice (2017) (7)
Nutritional Regulation of Insulin-Sensitive Glucose Transporter Gene Expression in Rat Cardiac Muscle (1993) (7)
GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice (2021) (6)
Insulin resistance and the metabolic syndrome. (2008) (6)
Antidiuretic hormone secretion and urine flow in aged catheterized patients. (1978) (6)
Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes (2016) (6)
Structural and functional studies on insulin receptors from alligator brain and liver. (1987) (6)
Fibronectin glycation increases IGF-I induced proliferation of human aortic smooth muscle cells (2012) (6)
Insulin and Insulin‐like Growth Factor‐I Induced Phosphorylation in Neurally Derived Cells (1993) (6)
The prolactin response to thyrotrophin-releasing hormone is intact in the human male castrate. (1981) (6)
Insulin receptors in lizard brain and liver: structural and functional studies of α and β subunits demonstrate evolutionary conservation (1986) (5)
Response to Comment on Home et al. Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges? Diabetes Care 2014;37:1499–1508 (2014) (5)
Non-viability of crossing the Alzheimer mouse model Tg2576 with the type 2 diabetes mouse model ob/ob (2014) (5)
IGF-I: panacea or poison? (2010) (5)
Status of Diabetes Care: New Challenges, New Concepts, New Measures—Focusing on the Future! (2015) (5)
Erratum to: Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes (2016) (5)
Insulin-Like Growth Factor Receptors in the Central Nervous System: Phosphorylation Events and Cellular Mediators of Biological Function (1989) (5)
Does a single nucleotide polymorphism in the FGFR explain the connection between diabetes and cancer? (2013) (5)
NIACIN DEFICIENCY (1952) (5)
Prevention of Type 2 Diabetes; from Science to Therapies (2012) (5)
Insulin and IGF-I receptors in neuroblastoma cells: Increases in mRNA and binding produced by glyburide (1989) (5)
Table 1, Criteria for Diagnosis of the Metabolic Syndrome (2015) (5)
The juxtamembrane but not the carboxyl-terminal domain of the insulin receptor mediates insulin's metabolic functions in primary adipocytes and cultured hepatoma cells. (2000) (5)
Diabetes Care: “Taking It to the Limit One More Time” (2016) (5)
Comparison of the counterregulatory hormone response to semisynthetic human insulin and purified porcine insulin in normal subjects and patients with type I diabetes mellitus. (1991) (5)
Status of Diabetes Care: “It Just Doesn’t Get Any Better . . . or Does It?” (2014) (4)
Diabetes in the aging male (2005) (4)
CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy (2016) (4)
Type 2 diabetes and cancer (2015) (4)
UEG Week 2016 Poster Presentations (2016) (4)
CHEMICAL CROSS TALK (1987) (4)
Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer (2011) (4)
Statement of Principle (2014) (4)
Evolutionary origins of intercellular communication systems: implications for mammalian biology. (1992) (4)
Controversies in treating diabetes : clinical and research aspects (2008) (4)
A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice. (2011) (4)
Synthesis: Deriving a Core Set of Recommendations to Optimize Diabetes Care on a Global Scale. (2016) (4)
Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling (2021) (3)
Endocrine Disorders During Pregnancy (2006) (3)
Ethnicity/culture modulates the relationships of the haptoglobin (Hp) 1‐1 phenotype with cognitive function in older individuals with type 2 diabetes (2016) (3)
Obesity and cancer (2022) (3)
A novel Drosophila insulin receptor: fly in the ointment or evolutionary conservation? (1995) (3)
Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using The Cre/Loxp System (44500) (2000) (3)
World leaders describe the latest in IGF research. (2018) (3)
Isolated partial deficiency of adrenocorticotrophic hormone. (1975) (3)
Obesity, Type 2 Diabetes & Cancer: The Insulin & Insulin-Like Growth Factor Connection 2 (2012) (3)
THE INTERPLAY BETWEEN ENDOCRINOLOGY AND ONCOLOGY: THE NEW ROLE OF THE ENDOCRINOLOGIST. (2017) (3)
Building Momentum: Taking on the Real “Issues” of Diabetes Care! (2015) (3)
Big Topics for Diabetes Care in 2018: Clinical Guidelines, Costs of Diabetes, and Information Technology (2018) (3)
Statin Use and Breast Cancer Prognosis in Black and White Women (2018) (3)
OR12,3 Insulin-like growth factor I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum (2008) (3)
Insulin Receptors in the Brain (1986) (3)
CONTROVERSIES IN TREATING DIABETES (2018) (3)
Deep sequencing of mRNA in CD24− and CD24+ mammary carcinoma Mvt1 cell line (2015) (3)
Endocrinology and Metabolism Clinics of North America. HIV and endocrine disorders. Foreword. (2014) (3)
Pulsatile Growth Hormone Secretory Pattern: Autofeedback Regulation and Effects on Growth Factors (1990) (3)
Loss of glucose homoeostasis: implications of basal glycaemia in type 2 diabetes * (2003) (3)
Bringing closure: towards achieving a better understanding of Israel (2019) (2)
Pediatric Endocrinology Update (2005) (2)
Lower Pre-Prandial Insulin and Altered Fuel Utilization in HIV/Antiretroviral-Exposed Infants in Cameroon. (2015) (2)
TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer (2021) (2)
Hormones and cancer: breast and prostate. (2011) (2)
The Effect of Leptin Administration on Mammary Tumor Growth in Diabetic Mice (2013) (2)
Breast cancer and diabetes. (2013) (2)
The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels (1995) (2)
P35 Reduced serum IGF-1 levels do not affect insulin-mediated mammary tumor progression in type 2 diabetes (2010) (2)
Breast Cancer Incidence After Risk-Reducing Salpingo-Oophorectomy in BRCA 1 and BRCA 2 Mutation Carriers (2012) (2)
Endocrinology and Metabolism Clinics of North America. Acute and chronic complications of diabetes. Foreword. (2013) (2)
Management of endocrine disorders during pregnancy. Foreword. (2011) (2)
Our evolving understanding of getting to goal using insulin in type 2 diabetes. (2007) (2)
Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis (2021) (2)
Effect of Acid on GIP Secretion in Man1 (1980) (2)
Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences (2002) (2)
Assessing the association of diabetes with lung cancer risk (2021) (2)
Hallmarks of cancer: The insulin-like growth factors perspective (2022) (2)
Diagnosis of Diabetes in Older Adults (2020) (2)
P-47 DELETION OF THE HEPATIC IGF-1 GENE IN TRAMP MICE LEADS TO DRAMATIC ALTERATIONS IN THE CIRCULATING IGF AXIS BUT DOES NOT REDUCE TUMOR PROGRESSION (2006) (2)
Intensive insulin therapy in the medical ICU. (2006) (2)
Two distinct insulin-related molecules in the guinea pig: immunological and biochemical characterization of insulin-like immunoactivity from extrapancreatic tissues of the guinea pig (1985) (2)
Association of Insulin Resistance and Higher Oncotype DX™ Recurrence Score (2021) (2)
Editorial: Hot Topics of Debate on Turner Syndrome: Growth, Puberty, Cardiovascular Risks, Fertility and Psychosocial Development (2019) (2)
Vitamin E Intake Is Associated with Lower Brain Volume in Haptoglobin 1-1 Elderly with Type 2 Diabetes. (2020) (2)
Syndromes associated with inappropriate hormone synthesis by tumors: an evolutionary interpretation. (1985) (2)
Postmenopausal Endocrinology. Foreword. (2015) (2)
Purification of fermentation products : applications to large-scale processes (1985) (2)
Endocrinology and metabolism clinics of North America. Foreword. (2008) (1)
Insulin-Like growth factors in health and disease. Foreword. (2012) (1)
Diabetes mellitus: associated conditions. Foreword. (2014) (1)
Insulin stimulates PKCζ -mediated phosphorylation of insulin receptor substrate-1 (IRS-1): A self-attenuated mechanism to negatively regulate the function of IRS proteins. (2018) (1)
Diabetes Care: “Lagniappe” and “Seeing Is Believing”! (2016) (1)
Foreword. Control of feeding behavior and the peripheral metabolism by the hypothalamus. (2008) (1)
Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure (2021) (1)
Analysis of Insulin and Insulin-Like Growth Factor-I Receptors in Neural Tissues (1992) (1)
Liver-derived insulin-like growth factor I is aregulator of the growth hormone secretion pattern in mice (2000) (1)
Foreword: Gastroenteropancreatic system and its tumors: Part 1. (2010) (1)
The Association of Depressive Symptoms With Brain Volume Is Stronger Among Diabetic Elderly Carriers of the Haptoglobin 1-1 Genotype Compared to Non-carriers (2019) (1)
Metabolic Syndrome Case (2015) (1)
Cancer Growth and Metastasis Circulating Insulin-like Growth Factor-I Levels Regulate Colon (2002) (1)
Effect of GH status on renal insulin-like growth factor I (IGF-I), IGF-I receptor, IGF-binding protein (IGFBP) and GH receptor mRNA levels in prepubertal rats (1994) (1)
Insulin therapy. Foreword. (2012) (1)
Dravet syndrome (severe myoclonic epilepsy of infancy) (2009) (1)
microRNAs: What the Clinician Should Know About This New Frontier (2014) (1)
Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE. (2003) (1)
The cyclin dependent kinase inhibitor p21 CIP/WAF is a positive regulator of IGF-1-induced Cell proliferation in MCF-7 human breast cancer cells (2003) (1)
Insulin and the Insulin-like Growth Factors in Health and Disease (1998) (1)
Emerging Concepts in the Role of IGFs and Cancer (2003) (1)
Case Study Responses (2007) (1)
Insulin Mechanisms/Metabolic Actions (2013) (1)
Although both rhGh and rhIGF-I have the potential to provide clinical benefit, each also has the potential to produce unwanted side-effects. (1999) (1)
Differential Expression of IGF-I and Insulin Receptor Isoforms in HPV Positive and Negative Human Cervical Cancer Cell Lines (2009) (1)
Research on growth hormone (GH) and the insulin-like growth factors (IGFs) (1998) (1)
Growth factors and cytokines in health and disease : a multi-volume treatise (1996) (1)
Autoimmunity and genetics : insulin synthesis and secretion (1994) (1)
Principles of Translational Medicine and Applications to Thyroid Cancer Investigation (2011) (1)
Hormones and other Messenger Molecules: An Approach to Unity (1984) (1)
Breast tumor Insulin-like growth factor receptor regulates cell adhesion and metastasis: Alignment of mouse single cell and human breast cancer transcriptomics (2021) (1)
SUN-131 The Roles of Two Insulin Receptor Isoforms in Triple Negative Breast Cancer Growth (2020) (1)
Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis (2022) (1)
Review the metabolism of vitamin D. Foreword. (2010) (1)
Insulin Receptor Substrate-1 PH and PTB Domains are Both Involved in Plasma Membrane Targeting (2001) (1)
Diabetes, glucose control, glucose lowering medications, and cancer risk: A 10-year population-based historical cohort (2012) (1)
Case study response (2009) (1)
Molecular Biology of the Somatomedins (1993) (1)
Endocrinology and Metabolism Clinics of North America. Pediatric endocrinology. Foreword. (2012) (1)
Erratum: Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp 185 (IRS-1) in intact rat livers (Journal of Biological Chemistry (1992) 267 (17483-17486)) (1993) (1)
NEUROPSYCHIATRIC SYMPTOMS ARE ASSOCIATED WITH COGNITIVE FUNCTION IN ELDERLY WITH TYPE 2 DIABETES (2016) (1)
Molecular Mechanisms of Insulin-like Growth Factor I Receptor Function: Implications for Normal Physiology and Pathological States (2011) (1)
Statement of principle. (2014) (1)
Transcriptional Diversity in Rat Insulin-Like Growth Factor I Gene Expression (1989) (0)
Recovery of rewarming after hypothermic hyperglycaemia. (1974) (0)
Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer’s Disease (2019) (0)
CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy (2016) (0)
P-48 TUMOR-DRIVEN ACTIVATION OF THE CIRCULATING GH-IGF SYSTEM RESULTS IN INCREASED SERUM IGF-1 LEVELS OF HEPATIC ORIGIN IN THE TRAMP MOUSE MODEL OF PROSTATE CANCER (2006) (0)
OR8,44 Increased levels of circulating IGF-I normalizes mammary gland development in mice deficient of local IGF-1 (2010) (0)
P34 Increased mammary tumor lung metastases in an MKR mouse model of type 2 diabetes (2010) (0)
Xenopus Zuevis Contains Two Nonallelic Preproinsulin Genes cDNA (2001) (0)
Racial differences in weight perception among breast cancer patients. (2015) (0)
New genes involved in the neoplastic transformation of the thyroid gland (2006) (0)
Hormones and the science of athletic performance. Foreword. (2010) (0)
Rat Brain/Hep G2 Glucose Transporter Gene Expression in Brain (1992) (0)
Adrenal cortical neoplasia. (2015) (0)
OR11,1 Liver-derived circulating IGF-I is sufficient to restore linear growth in an IGF-I null mouse (2008) (0)
Insulin-Like Growth Factors During Development (1995) (0)
Unregulated LDL cholesterol uptake is detrimental to breast cancer cells. (2022) (0)
A Message from the Editor-in-Chief. (2017) (0)
PL06 CIRCULATING IGF-I LEVELS AS A RISK FACTOR IN THE ACCELERATED TUMOR GROWTH IN OBESE MICE (2006) (0)
A Message from the Editor-in-Chief. (2016) (0)
Pediatric endocrinology: part I. Foreword. (2009) (0)
The obesity pandemic: meeting the clinical challenges. (2010) (0)
Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim (2012) (0)
Pediatric endocrinology: Part II. Foreword. (2009) (0)
Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer (2010) (0)
Biology of IGF-I: Its interaction with insulin in health and malignant States Novartis Foundation Symposium No. 263 London, 13-16 October 2003 (2003) (0)
Bidirectional impact of endocrine disorders. (2013) (0)
Insulin and Insulin-Like Growth Factor I Mediated Phosphorylations in Mouse Neuroblastoma N18 Cells: A Model for Studying Insulin and IGF-I Action on Neural Tissue (1989) (0)
The growth hormone/insulin-like growth factor-1 axis in health and disease (2007) (0)
IGF-I induces MDM2-dependent degradation of p53 via the p38 MAP Kinase pathway in response to DNA damage (2002) (0)
Abstracts from the Thirteenth Rambam Research Day, December 22, 2016 (2017) (0)
Mouse Models Used to Study the Effects of Diabetes, Insulin, and IGFs on Cancer (2015) (0)
A MESSAGE FROM THE EDITOR-IN-CHIEF. (2018) (0)
Foreword: Gastroenteropancreatic system and its tumors: Part 2. (2011) (0)
Receptor Purification, 174, Gerald Litwack (Ed.). Humana, Clifton, NJ (1990), 501, $89.50 (1991) (0)
Expert opinion provided (2006) (0)
Ethnicity/culture modulates the relationships of the haptoblobin (Hp) 1-1 phenotype with cognitive function in elderly with type 2 diabetes (2015) (0)
Reduced circulating IGF-I levels delays the onset of chemically induced mammary tumors (2004) (0)
ASpecial Focus on Obesity. (2006) (0)
Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER + breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein (2012) (0)
O-34: Characterization of the specific interaction of Crk with the IGF-I receptor (2009) (0)
Thyroid cancer and other thyroid disorders. (2014) (0)
Type I diabetes. Foreword. (2010) (0)
[Increased blood parathormone (PTH) level in a case of hyperprolactinemia]. (1977) (0)
Loss of Adipose GHR in Mice Enhances Local Fatty Acid Trapping and Impairs BAT Thermogenesis (2019) (0)
Foreword: Endocrine Hypertension (2011) (0)
Doctorate Program in Molecular Oncology and Endocrinology XVIII cycle-2002–2006 Coordinator: Prof. Giancarlo Vecchio “NOVEL MECHANISMS RESPONSIBLE FOR CONTROLLING GLUCOSE-INDUCED INSULIN SECRETION IN PANCREATIC BETA-CELLS” (2006) (0)
the Level of IGF-I Receptor Expression Insulin-like Growth Factor-I ( IGF-I ) Is Dependent on the Dose Stimulation of Tumor Growth by Recombinant Human Updated (2006) (0)
Insulin-Like Growth Factor I Is a Positive Regulator of Thymic Function. (2004) (0)
OR1,1 b cell specific disruption of the growth hormone receptor impair b cell insulin secretion (2010) (0)
OR8-2: Insulin-like growth factor receptor inhibition in mammary epithelium enhances Wnt1- mediated tumors, canonical Wnt signaling and IGF-II/insulin-receptor A expression (2014) (0)
Anti-diabetic therapy inhibits mammary tumor progression Insulin sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression Running Title: Anti-diabetic therapy inhibits mammary tumor progression (2009) (0)
A Message from the Editor-in-Chief. (2019) (0)
Basic aspects and clinical applicability in the field of lipidology. Foreword. (2009) (0)
Hormonal Regulation of the Vascular System: An Overview (2009) (0)
Management of Type 2 Diabetes Mellitus in the Very Elderly: One Practice's Experience. (2023) (0)
TheGrowth-Stimulatory Effect ofSimian Virus 40TAntigen Requires theInteraction ofInsulinlike GrowthFactor 1 withItsReceptor (1992) (0)
Chair's Introduction (2008) (0)
Abstract 1004: LDLR knockdown reduces the growth of Her2 overexpressing breast cancer in mouse models of hyperlipidemia (2017) (0)
Title: Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-1 receptor (2013) (0)
GP2-3: The role of the insulin receptor in breast cancer progression (2014) (0)
A meeting of the minds (2006) (0)
The insulin-like growth factor system and cancer: what are the implications? (2012) (0)
The Role of Growth Hormone and Insulin-Like Growth 98 Factor-1 in the Treatment of Idiopathic Short Stature (2007) (0)
Erratum: Distinct promoters in the rat insulin-like growth factor-I (IGF- I) gene are active in CHO cells (Endocrinology (1993) 132 (935-937)) (1993) (0)
OR1,2 Targeted ablation of growth hormone receptors in the skeletal muscle improves metabolism and protects against diet-induced obesity in mice (2010) (0)
A functional IGF‐I receptor is not necessary for in vivo skeletal muscle hypertrophy (2007) (0)
DYSENTERY. (1950) (0)
Abstract P4-13-08: Diabetes, Related Factors and Breast Cancer Risk (2012) (0)
Distinct lipidomic signatures in persons living with HIV: combined analysis of ACTG 5260s and MACS/WIHS. (2021) (0)
A Message from the Editor-in-Chief. (2015) (0)
Hyperinsulinaemia in cancer (2020) (0)
Insulin resistance contributes to racial disparities in breast cancer prognosis in US women (2020) (0)
Osteoporosis. Foreword. (2012) (0)
Lipids 2014: new guidelines, new concepts, new diets, new drugs. (2014) (0)
The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary (cid:1) T3 Cells by Protein Kinase C (cid:1) -mediated Negative Regulation of Akt* □ S (2004) (0)
PL12 Growth hormone and IGF-1 in mouse models of growth and metabolism (2012) (0)
The articles cover all of the aspects from a basic and practical point of view. Foreword. (2008) (0)
Comprar Metabolic Syndrome, An Issue of Medical Clinics | Derek LeRoith | 9781416055327 | Saunders (2008) (0)
Doctorate Program in Molecular Oncology and Endocrinology (2006) (0)
Metformin and Cancer: Is this the end? (2022) (0)
Corticotropin and j 3-endorphin-like materials are native to unicellular organisms ( Tetrahymena pyriformi / high-pressure liquid chromatography / gel filtration / radioreceptor assay / bioassay ) (0)
Iconography : Non-islet cell hypoglycemia (2008) (0)
The Life and Works of Solomon Epstein, MD, FRCP (1940–2020) (2020) (0)
Abstract 542: Mice with Cardiomyocyte-Restricted IGF-1 Receptor Deletion Exhibit Diminished Cardiomyocyte Size and Resistance to Exercise-Induced Cardiac Hypertrophy (2007) (0)
Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture (2008) (0)
Hyperinsulinemia Promotes Metastasis to the Lung in a Mouse Model of Her2mediated (2013) (0)
RAT GH RECEPTOR/GH-BINDING PROTEIN mRNAs KITH DIVERGENT 5′-UNTRANSLATED REGIONS ARE EXPRESSED IN A TISSUE- AND TRANSCRIPT-SPECIFIC MANNER (1995) (0)
O-12: Roles of the tyrosine residues in the carboxyterminal domain of the IGF-I receptor (2009) (0)
Insulin resistance and racial disparities in breast cancer prognosis: a multi-center cohort study. (2022) (0)
A MESSAGE FROM THE EDITOR-IN-CHIEF. (2020) (0)
SAT-151 Regulation of Low-Density Lipoprotein Receptor Expression in Triple Negative Breast Cancer (2020) (0)
#511 Insulin‐like Growth Factor‐I Receptor is Necessary for EWS/FLI‐1 Induced Transformation of Fibroblasts (1996) (0)
Race, subjective social status and metabolic syndrome in women with breast cancer. (2021) (0)
Editorial: A blast from the past--insulin does it again! (2004) (0)
Reproductive Endocrinology. (2015) (0)
Molecular Basis of Inherited Pancreatic Disorders (2006) (0)
Table 2, Therapy for individual risk factors (2015) (0)
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment (2018) (0)
Circulating insulin-like growth factor-I regulates colon cancer growth and metastasis (2004) (0)
New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut (2017) (0)
Biology of IGF-I (2003) (0)
Histological features of primary mammary tumor in LID mice induced by 7, 12-dimethybenz(a) anthracesn (2004) (0)
Case study responses: Expert Opinion provided by Derek LeRoith, MD, PhD (2006) (0)
Breast tumor IGF1R regulates cell adhesion and metastasis: alignment of mouse single cell and human breast cancer transcriptomics (2022) (0)
Insulin receptors in lizard brain and liver: structural and functional studies of alpha and beta subunits demonstrate evolutionary conservation. (1986) (0)
Corticotropin and f3-endorphin-likc unicellular organisms (2016) (0)
Construction and culture of mouse hepatocytes over expressing zebrafish insra (2008) (0)
Endocrine hypertension. Forward. (2011) (0)
Insulin, IGFs and Growth Hormone: From Basic Research to Novel Clinical Applications: Interlaken, October 1993 (1994) (0)
Prevention of Type 2 Diabetes (2012) (0)
Endocrinology and Metabolism Clinics of North America. Neuroendocrine control of metabolism. Foreword. (2013) (0)
Are racial differences in obesity and insulin resistance related to aggressive breast cancer? (2019) (0)
Subjective social status, race, and metabolic syndrome in women with breast cancer. (2023) (0)
Comprar Obesity, An Issue Of Medical Clinics, Vol. 95-5 | Eddy Karnieli | 9781455723690 | Saunders (2011) (0)
Are racial differences in obesity and insulin resistance related to aggressive breast cancer (2016) (0)
OR10,57 Insulin-like growth factor signaling regulates stem/progenitor cells in the epithelium of virgin mouse mammary glands (2010) (0)
Development and Evaluation of Comprehensive Type II Diabetes Program Utilizing Board Certified Advanced Diabetes Managers in Primary Care (2019) (0)
How cells communicate: A broad perspective. (1987) (0)
The year in diabetes 2001 Gomis and Page (eds) Oxford, UK: Clinical Publishing Services Ltd, 2002. No of pages: 328. (hardback). ISBN: 0953733963 (2002) (0)
This issue of Endocrinology and Metabolism Clinics focuses on clinical and molecular advances in autoimmune endocrine conditions. Foreword. (2009) (0)
1172-P: GLUT4-Overexpressing Engineered Muscle Tissue Implants as a Potential Novel Therapy for Type 2 Diabetes: Lessons from Diabetic Mice (2019) (0)
Incomplete Activation of the IGF-1 Signaling Pathway after High-frequency Electrically Stimulated Skeletal Muscle Contractions: 1714 (2010) (0)
CLINICAL STUDIES IN FEMALE REPRODUCTION I SSRI Use in the Peripartum Period Regulates Mammary Gland Parathyroid Hormone Related Protein (PTHrP) by a Serotonylation-Dependent Mechanism (2020) (0)
382-P: Insulin Requirements after Hospital Discharge in Patients with Type 2 Diabetes (2019) (0)
Comprar Year Book Of Medicine 2016 | K. DeVault | 9780323446860 | Elsevier España (2016) (0)
Autoimmune Endocrine Disorders Foreword (2009) (0)
5 Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways : Similarities and Differences (0)
GREATER ADIPOSITY IS ASSOCIATED WITH SMALLER BRAIN VOLUME IN ELDERLY WITH TYPE 2 DIABETES (2019) (0)
Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes (2012) (0)
Statement of Principle (1990) (0)
CD24+ cells fuel rapid tumor growth and display high metastatic capacity (2015) (0)
Racial differences in weight perception among Black and White women diagnosed with breast cancer. (2022) (0)
aging Growth hormone receptor signaling is dispensable for HSC function and (2014) (0)
Aging and endocrinology. Foreword. (2013) (0)
Growth Hormone-Binding Protein (Gh-Bp) Induction in Renal Cortex of Streptozotocin (Stz) -Diabetic Rats (1997) (0)
Editorial: What's New in Endocrinology? (2019) (0)

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What Schools Are Affiliated With Dr. Derek Leroith?

Dr. Derek Leroith is affiliated with the following schools:

Icahn School of Medicine at Mount Sinai

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Dr. Derek Leroith's Published Works

Published Works

What Schools Are Affiliated With Dr. Derek Leroith?

Dr. Derek Leroith's AcademicInfluence.com Rankings