Dyann Wirth
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American immunologist
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Biology
Dyann Wirth's Degrees
- PhD Immunology University of Chicago
Why Is Dyann Wirth Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dyann F. Wirth is an American immunologist. She is currently the Richard Pearson Strong Professor of Infectious Diseases at Harvard T.H. Chan School of Public Health. Wirth is one of the world's leading malariologists, dealing with how the genus Plasmodium has evolved in terms of population biology, drug resistance, and antigenicity. The Wirth laboratory combines the expertise of the Harvard School of Public Health, the Broad Institute, and international collaborators for malaria research and training in public health.
Dyann Wirth's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. (1989) (447)
- Amplification of kinetoplast DNA as a tool in the detection and diagnosis of Leishmania. (1990) (437)
- Proposal for a common oligosaccharide intermediate in the synthesis of membrane glycoproteins (1977) (360)
- A genome-wide map of diversity in Plasmodium falciparum (2007) (311)
- Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine. (2015) (287)
- A Research Agenda for Malaria Eradication: Drugs (2011) (287)
- Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. (1993) (283)
- Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase (2011) (275)
- Transformed mammalian cells secrete specific proteins and phosphoproteins (1979) (275)
- A Research Agenda for Malaria Eradication: Vaccines (2011) (248)
- Distinct physiological states of Plasmodium falciparum in malaria-infected patients (2007) (246)
- Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum (2017) (208)
- A Systematic Map of Genetic Variation in Plasmodium falciparum (2006) (204)
- A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking (2008) (200)
- malERA: An updated research agenda for malaria elimination and eradication (2017) (198)
- Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (2016) (190)
- Recent Origin of Plasmodium falciparum from a Single Progenitor (2001) (182)
- Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions. (1982) (176)
- High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery (2006) (169)
- Drugs for neglected diseases: a failure of the market and a public health failure? (2001) (169)
- SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes (2010) (167)
- Malaria, the submerged disease. (1996) (164)
- Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics (2017) (161)
- A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction. (1992) (154)
- Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene (1992) (153)
- Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity (2017) (150)
- Primary structure of the Streptomyces enzyme endo-beta-N-acetylglucosaminidase H. (1984) (150)
- Serial analysis of gene expression in Plasmodium falciparum reveals the global expression profile of erythrocytic stages and the presence of anti-sense transcripts in the malarial parasite. (2001) (149)
- Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. (2007) (148)
- Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance. (1998) (145)
- Modeling malaria genomics reveals transmission decline and rebound in Senegal (2015) (143)
- Application of the polymerase chain reaction to the epidemiology of pathogenic and nonpathogenic Entamoeba histolytica. (1993) (141)
- Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum (2009) (135)
- Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA (2015) (134)
- Stable expression of the bacterial neo r gene in Leishmania enriettii (1990) (128)
- Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence (2008) (124)
- Selection of Plasmodium falciparum Multidrug Resistance Gene 1 Alleles in Asexual Stages and Gametocytes by Artemether-Lumefantrine in Nigerian Children with Uncomplicated Falciparum Malaria (2008) (124)
- A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs (2011) (123)
- Specific DNA probe for the diagnosis of Plasmodium falciparum malaria. (1986) (122)
- Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model* (2010) (119)
- Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection (2018) (119)
- Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. (2008) (117)
- Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. (2006) (114)
- In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. (2005) (114)
- How a single sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins (1977) (114)
- Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. (2004) (113)
- Gender distribution in asymptomatic and invasive amebiasis (2000) (113)
- Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. (2005) (111)
- A High-Throughput Screen Targeting Malaria Transmission Stages Opens New Avenues for Drug Development (2011) (109)
- Isolation and Functional Characterization of Two Distinct Sexual-Stage-Specific Promoters of the Human Malaria Parasite Plasmodium falciparum (1999) (105)
- Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite (2012) (104)
- Identification of regulatory elements in the Plasmodium falciparum genome. (2004) (103)
- Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections (2015) (103)
- Harnessing genomics and genome biology to understand malaria biology (2012) (99)
- Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. (2004) (98)
- Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum (2002) (97)
- Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum. (1995) (97)
- A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies (2011) (96)
- Hybrid selection for sequencing pathogen genomes from clinical samples (2011) (96)
- Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia (2017) (95)
- Transfection of Leishmania enriettii and expression of chloramphenicol acetyltransferase gene. (1989) (95)
- Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. (2010) (94)
- A broad analysis of resistance development in the malaria parasite (2016) (94)
- Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt (2015) (93)
- Tandem arrangement of tubulin genes in the protozoan parasite Leishmania enriettii (1983) (92)
- Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility (2018) (89)
- Fourteen polymorphic microsatellite DNA markers for the human malaria parasite Plasmodium vivax (2006) (88)
- Gene expression in Leishmania: analysis of essential 5' DNA sequences. (1992) (88)
- Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal (2013) (87)
- In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. (2002) (86)
- Characterization of a RNA virus from the parasite Leishmania. (1989) (86)
- Open-source discovery of chemical leads for next-generation chemoprotective antimalarials (2018) (83)
- Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii. (1993) (80)
- Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum (2011) (80)
- Identification and Characterization of Small Molecule Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase* (2008) (80)
- Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from Plasmodium falciparum (2009) (79)
- hmmIBD: software to infer pairwise identity by descent between haploid genotypes (2017) (78)
- Structure of the murine leukemia virus envelope glycoprotein precursor (1979) (77)
- Cloning and characterization of an Onchocerca volvulus specific DNA sequence. (1989) (76)
- Sequence analysis and amplification by polymerase chain reaction of a cloned DNA fragment for identification of Mycobacterium tuberculosis (1990) (76)
- Kinetoplast DNA minicircles: regions of extensive sequence divergence. (1987) (76)
- Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum (2018) (75)
- Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins (2013) (73)
- Cloning and characterization of a Leishmania gene encoding a RNA spliced leader sequence. (1986) (71)
- Clonal outbreak of Plasmodium falciparum infection in eastern Panama. (2014) (70)
- Leishmaniasis and malaria: new tools for epidemiologic analysis. (1986) (70)
- Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria (2003) (70)
- Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. (2007) (68)
- Sequence identification of cytochrome b in Plasmodium gallinaceum. (1989) (66)
- Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. (2010) (66)
- The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs (2015) (65)
- COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data (2015) (65)
- Patterns of Gene-Specific and Total Transcriptional Activity during the Plasmodium falciparum Intraerythrocytic Developmental Cycle (2009) (65)
- Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests (2014) (64)
- Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. (2000) (62)
- Dietary restriction protects against experimental cerebral malaria via leptin modulation and T cell mTORC1 suppression (2014) (62)
- Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. (2007) (61)
- RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. (2005) (61)
- Malaria life cycle intensifies both natural selection and random genetic drift (2013) (60)
- Drug‐induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum (2003) (60)
- Genus- and species-specific DNA probes to identify mycobacteria using the polymerase chain reaction. (1990) (60)
- Rapid, Field-Deployable Method for Genotyping and Discovery of Single-Nucleotide Polymorphisms Associated with Drug Resistance in Plasmodium falciparum (2012) (60)
- Diagnosis of Mycobacterium avium bacteremia by polymerase chain reaction (1993) (59)
- In vivo transcriptional profiling of Plasmodium falciparum (2004) (59)
- On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs (2014) (59)
- The paradoxical population genetics of Plasmodium falciparum. (2002) (58)
- Plasmodium falciparum and P. vivax: factors affecting sensitivity and specificity of PCR-based diagnosis of malaria. (1994) (58)
- Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. (2009) (58)
- Characterization of a conserved extrachromosomal element isolated from the avian malarial parasite Plasmodium gallinaceum (1989) (56)
- The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission (2014) (56)
- Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. (2006) (54)
- Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. (2012) (53)
- Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies (2010) (52)
- Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. (2003) (52)
- High prevalence of mefloquine-resistant falciparum malaria in eastern Thailand. (1993) (52)
- Chromosome location of four genes in Leishmania. (1986) (51)
- Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance (2013) (51)
- In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth* (2014) (50)
- Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes. (2001) (49)
- Inferring Developmental Stage Composition from Gene Expression in Human Malaria (2013) (49)
- Molecular Analysis of Erythrocyte Invasion in Plasmodium falciparum Isolates from Senegal (2007) (48)
- Mapping of the Plasmodium falciparum multidrug resistance gene 5′‐upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites (2003) (47)
- Identification of visceral Leishmania species with cloned sequences of kinetoplast DNA. (1986) (47)
- Transfected Leishmania expressing biologically active IFN-gamma. (1993) (47)
- Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. (1993) (47)
- The parasite genome: Biological revelations (2002) (46)
- Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria (2011) (46)
- Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. (2011) (46)
- Expression of the Streptomyces enzyme endoglycosidase H in Escherichia coli. (1981) (44)
- Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate (2015) (43)
- New Targets for Antimalarial Drug Discovery (1997) (43)
- A DNA probe cloned in Escherichia coli for the identification of Brugia malayi. (1986) (43)
- Fetuin-A, a Hepatocyte-Specific Protein That Binds Plasmodium berghei Thrombospondin-Related Adhesive Protein: a Potential Role in Infectivity (2005) (42)
- Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal (2005) (41)
- Creation of Null/+ mutants of the alpha-tubulin gene in Leishmania enriettii by gene cluster deletion. (1992) (40)
- A genomic and evolutionary approach reveals non-genetic drug resistance in malaria (2014) (40)
- Requirements for the insertion of the Sindbis envelope glycoproteins into the endoplasmic reticulum membrane (1979) (40)
- Genetic Diversity and Protective Efficacy of the RTS , S / AS 01 Malaria Vaccine (2015) (39)
- Detection of untreated mycobacteria by using polymerase chain reaction and specific DNA probes (1991) (39)
- Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. (2007) (39)
- Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda (2016) (38)
- Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal (2017) (38)
- Characterization of the pfmdr2 gene for Plasmodium falciparum. (1994) (38)
- Control of tubulin gene expression in the parasitic protozoan Leishmania enriettii (1984) (38)
- DNA hybridization probe for clinical diagnosis of Entamoeba histolytica (1989) (37)
- Detection of Plasmodium falciparum infection in human patients: a comparison of the DNA probe method to microscopic diagnosis. (1989) (37)
- Relationship between Chloroquine Toxicity and Iron Acquisition in Saccharomyces cerevisiae (2002) (37)
- Characterization of an Onchocerca-specific DNA clone from Onchocerca volvulus. (1987) (37)
- MalDA, Accelerating Malaria Drug Discovery (2021) (36)
- Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia. (2016) (36)
- Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal (2017) (36)
- New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (2016) (35)
- The avian malaria Plasmodium lophurae has a small number of heterogeneous ribosomal RNA genes. (1983) (35)
- Detection of Leishmania within sand flies by kinetoplast DNA hybridization. (1988) (35)
- Cloning, genomic organization and transcription of the Entamoeba histolytica α-tubulin-encodmg gene (1994) (35)
- Comparison of thick films, in vitro culture and DNA hybridization probes for detecting Plasmodium falciparum malaria. (1989) (35)
- Generation of sequence diversity in the kinetoplast DNA minicircles of Leishmania mexicana amazonensis. (1988) (34)
- SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites (2012) (34)
- Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors (2009) (34)
- A framework for microbiome science in public health (2021) (33)
- Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites (2004) (33)
- Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers (2015) (32)
- Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum (2009) (32)
- Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors (2014) (31)
- Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal (2013) (31)
- Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum (2011) (31)
- Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. (2008) (31)
- Homologous recombination in Leishmania enriettii. (1991) (31)
- Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal☆ (2013) (31)
- A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. (2010) (31)
- In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes. (2012) (30)
- Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing (2018) (30)
- Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. (2012) (30)
- Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes (2016) (30)
- A new reporter gene for transient transfection of Plasmodium falciparum (2002) (30)
- 3' UTR elements enhance expression of Pgs28, an ookinete protein of Plasmodium gallinaceum. (2000) (29)
- Transformation-specific secreted phosphoproteins (1980) (29)
- Stage-specific transcripts of the Plasmodium falciparum pfmdr 1 gene. (1993) (29)
- Identification of Brugia malayi in vectors with a species-specific DNA probe. (1986) (29)
- Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. (2015) (29)
- Technical Assessment of the Affymetrix Yeast Expression GeneChip YE6100 Platform in a Heterologous Model of Genes That Confer Resistance to Antimalarial Drugs in Yeast (2000) (28)
- Structure of mRNA encoded by tubulin genes in Leishmania enriettii. (1985) (28)
- Transfection of malaria parasites (1996) (28)
- Human cerebral malaria and Plasmodium falciparum genotypes in Malawi (2012) (28)
- Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission (2018) (27)
- Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa (2006) (27)
- Identification of a cis-acting gene regulatory element from the lemdr1 locus of Leishmania enriettii. (1994) (27)
- Naturally acquired immunity against immature Plasmodium falciparum gametocytes (2019) (27)
- Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents (2014) (27)
- Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. (2012) (26)
- Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. (2006) (26)
- The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites. (2007) (26)
- Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. (2012) (25)
- Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia (2014) (25)
- Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance (2018) (25)
- Inactivation of Plasmepsins 2 and 3 Sensitizes Plasmodium falciparum to the Antimalarial Drug Piperaquine (2018) (25)
- In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal (2005) (24)
- Genetic characterization of an epidemic of Plasmodium falciparum malaria among Yanomami Amerindians. (1999) (24)
- Short report: detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru. (1998) (24)
- Transcriptional mapping of Leishmania enrietti tubulin mRNAs. (1986) (24)
- RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands (2015) (23)
- Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. (2014) (23)
- Generation of species-specific DNA probes for Leishmania aethiopica. (1991) (23)
- Characterization of the pfmdr2 gene for Plasmodium falciparum. (1993) (22)
- A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. (2010) (22)
- Transcriptional Profiling of Plasmodium falciparum Parasites from Patients with Severe Malaria Identifies Distinct Low vs. High Parasitemic Clusters (2012) (22)
- Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element. (2003) (22)
- Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum Surface Antigens and Possible Vaccine Candidates* (2017) (22)
- Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections (2018) (21)
- trans splicing in Leishmania enriettii and identification of ribonucleoprotein complexes containing the spliced leader and U2 equivalent RNAs (1988) (21)
- Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal (2012) (21)
- In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model (2019) (20)
- West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The Gambia. (2016) (20)
- A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors. (2016) (19)
- Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites (2016) (19)
- Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention (2021) (19)
- A cloned DNA fragment for identification of Mycobacterium tuberculosis. (1989) (18)
- Secreted Antibody Is Required for Immunity to Plasmodium berghei (2008) (17)
- Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria (2006) (16)
- Global action for training in malaria elimination (2018) (16)
- Leishmaniasis and Malaria: DNA Probes for Diagnosis and Epidemiologic Analysis a (1989) (16)
- Functional analysis of pfmdr1 gene of Plasmodium falciparum. (1998) (16)
- Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding☆ (2018) (15)
- Improving malaria control in West Africa: interruption of transmission as a paradigm shift. (2012) (15)
- A homologous recombination strategy to analyze the vinblastine resistance property of the V-circle in Leishmania. (1994) (15)
- Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya. (1989) (14)
- Characterization of a ribosomal DNA clone of Brugia malayi. (1986) (14)
- Deletion analysis of the 5' flanking sequence of the Plasmodium gallinaceum sexual stage specific gene pgs28 suggests a bipartite arrangement of cis-control elements. (2001) (14)
- De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria (2017) (14)
- malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication (2017) (13)
- Prioritization of Molecular Targets for Antimalarial Drug Discovery (2021) (13)
- Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal (2003) (13)
- Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode (2018) (13)
- Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum (2018) (13)
- Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks. (2017) (12)
- Plasmodium falciparum gene expression measured directly from tissue during human infection (2014) (12)
- Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso (2019) (12)
- High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations (2017) (12)
- Characterization of an ATP-binding cassette transporter in Cryptosporidium parvum. (1997) (12)
- Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs (2013) (12)
- Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine. (2021) (12)
- Malaria: A 21st century solution for an ancient disease (1998) (12)
- Immune Characterization of Plasmodium falciparum Parasites with a Shared Genetic Signature in a Region of Decreasing Transmission (2014) (11)
- Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum (2020) (11)
- Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. (2007) (11)
- A sequence insertion targeting vector for Leishmania enriettii. (1992) (11)
- The cloned rRNA genes of P. lophurae: a novel rDNA structure. (1983) (11)
- Isolation and characterization of an α-tubulin gene from Leishmania enriettii (1983) (11)
- Chapter 33. Malaria: A Third World Disease in Need of First World Drug Development (1999) (11)
- Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients (2015) (10)
- Mutations in PFCRT K76T do not correlate with sulfadoxine–pyrimethamine–amodiaquine failure in Pikine, Senegal (2008) (9)
- The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance (2021) (9)
- Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal (2020) (9)
- Mutational analysis of a signal sequence required for protein secretion in Leishmania major. (1993) (9)
- Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria (2015) (8)
- Polymorphisms in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and multidrug-resistant gene 1 (Pfmdr-1) in Nigerian children 10 years post-adoption of artemisinin-based combination treatments. (2020) (8)
- In vivo profiles in malaria are consistent with a novel physiological state (2009) (8)
- Transformation-specific secreted proteins. (1980) (7)
- Sequence of a small ribosomal RNA gene from Plasmodium lophurae. (1989) (7)
- Transcriptional Categorization of the Etiology of Pneumonia Syndrome in Pediatric Patients in Malaria-Endemic Areas (2016) (7)
- Studies of induced radioactivity and residual dose rates around beam absorbers of different materials (2010) (7)
- Biomarkers to Distinguish Bacterial From Viral Pediatric Clinical Pneumonia in a Malaria-Endemic Setting (2020) (7)
- Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia (2020) (7)
- [In vitro evaluation of the sensitivity of Plasmodium falciparum to chloroquine using the deli-microtest in region of Dakar, Senegal]. (2005) (7)
- Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations (2021) (7)
- DNA probes as epidemiological tools for surveillance of Plasmodium falciparum malaria in Thailand. (1994) (7)
- Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream region. (2005) (7)
- RAPID IDENTIFICATION OF LEISHMANIA SPECIES USING SPECIFIC HYBRIDIZATION OF KINETOPLAST DNA SEQUENCES (1985) (6)
- 0355 in Plasmodium falciparum (2011) (6)
- An Adjustable Gas-Mixing Device to Increase Feasibility of In Vitro Culture of Plasmodium falciparum Parasites in the Field (2014) (6)
- Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering (2020) (6)
- Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique (2021) (6)
- Quantitative imaging of intraerythrocytic hemozoin by transient absorption microscopy (2019) (5)
- Plasmodium falciparum proteinases: Targeted drug development (1996) (5)
- Use of a Plasmodium vivax genetic barcode for genomic surveillance and parasite tracking in Sri Lanka (2020) (5)
- The Cytoplasmic Prolyl-tRNA Synthetase of the Malaria Parasite is a Dual-Stage Target for Drug Development (2015) (5)
- P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers (2019) (5)
- Plasmodium falciparum population genetic complexity influences transcriptional profile and immune recognition of highly related genotypic clusters (2020) (5)
- ML238: An Antimalarial Small Molecule of a Unique Structural Class (2011) (4)
- Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance (2022) (4)
- Reply to Velavan et al.: Polymorphisms of pfcoronin in natural populations: Implications for functional significance (2019) (4)
- Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance (2022) (4)
- Host Cell Proteins Bind Specifically to the Capsid-Cleaved 5' End of Leishmaniavirus RNA1 (1999) (3)
- In vivo transcriptional profiling of P . falciparum (2004) (3)
- COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data (2015) (3)
- Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. (2011) (3)
- Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status (2017) (3)
- Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode (2018) (3)
- Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing (2021) (3)
- A genomic and evolutionary approach reveals non-genetic drug resistance in malaria (2014) (3)
- Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA (2015) (3)
- The primary structure of the rRNA insertions of Plasmodium lophurae. (1985) (3)
- The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling. (2019) (3)
- Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies (2022) (3)
- R H: a genetic metric for measuring intrahost Plasmodium falciparum relatedness and distinguishing cotransmission from superinfection (2022) (2)
- The signal sequence and C-terminal hydrophobic domain are required for localization of the sexual stage antigen pgs28 to the surface of P. gallinaceum ookinetes. (2000) (2)
- Modeling the levels, trends, and connectivity of malaria transmission using genomic data from a health facility in Thies, Senegal (2021) (2)
- Genetic analysis reveals unique characteristics of Plasmodium falciparum parasite populations in Haiti (2020) (2)
- Genomic investigation of atypical malaria cases in Kanel, northern Senegal (2020) (2)
- Molecular biology of Leishmania. (1990) (2)
- Human cerebral malaria and Plasmodium falciparum genotypes in Malawi (2012) (2)
- Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. (2012) (2)
- Limited variation of the 5'cis-control region of the transmission blocking vaccine candidate Pfs25 amid great genetic diversity of Plasmodium falciparum in Cameroon (2008) (2)
- Genotyping malaria parasites to understand malaria transmission (2015) (1)
- Detection ofUntreated Mycobacteria byUsingPolymerase Chain Reaction andSpecific DNA Probes (1991) (1)
- Plasmodium falciparumgene expression measured directly from tissue during human infection (2014) (1)
- Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model (2016) (1)
- Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia (2017) (1)
- Additional file 16 (2011) (1)
- Response: malaria diagnosis. (1987) (1)
- Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum (2018) (1)
- Amplicon deep sequencing of low-density Plasmodium falciparum infections: an evaluation of analysis approaches (2018) (1)
- Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests (2014) (1)
- IDENTIFICATION OF THE PLASMODIUM FALCIPARUM ACETYL-COA SYNTHETASE AS AN EMERGING ANTIPLASMODIAL DRUG TARGET (2019) (1)
- Characterization of the filarial genome. (1987) (1)
- Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal (2023) (1)
- Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy inducedby the RTS,S malaria vaccine (2020) (1)
- Genomic investigation of atypical malaria cases in Kanel, northern Senegal (2021) (0)
- Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal (2017) (0)
- Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation (2023) (0)
- Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (2020) (0)
- Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal (2020) (0)
- Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration. (2018) (0)
- The Lipid-Linked Oligosaccharide and Its Role in Glycoprotein Synthesis (1979) (0)
- ACT PARTNER DRUG EROSION: EVIDENCE OF PIPERAQUINE-RESISTANT PLASMODIUM FALCIPARUM IN CAMBODIA (2017) (0)
- DNA Probes in the Diagnosis of Parasitic Infections (1991) (0)
- IDENTIFICATION OF A DUAL LIVER-ASEXUAL STAGE ANTIMALARIAL TARGETING PFDHODH (2018) (0)
- Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia (2014) (0)
- Original ContributionGender distribution in asymptomatic and invasive amebiasis (2000) (0)
- Kinetoplast DNA minicircies : Regions of extensive sequence divergence ( Leishmania / hybridization / taxonomy / mitochondrial DNA / diagnosis ) WILLIAM 0 (0)
- Diagnosis ofMycobacterium aviumBacteremia by Polymerase ChainReaction (1993) (0)
- On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs (2014) (0)
- Investigation of the Thai multidrug resistant Plasmodium falciparum C2A strain in the Aotus monkey model (2014) (0)
- Anti-malarial Activity in the Mouse Model Dihydroorotate Dehydrogenase with Plasmodium falciparum Novel Inhibitors of Molecular Bases of Disease : (2010) (0)
- Malaria Gordon Conference. (1999) (0)
- DETECTION OF PLASMODIUM FALCIPARUM IN BLOOD USING DNA PROBE, pPF 14 (1989) (0)
- Malaria: new tools for epidemiological analysis (1986) (0)
- Antimalarials in mosquitoes overcome Anopheles and Plasmodium resistance to malaria control strategies (2022) (0)
- SYNTHESIS AND MATURATION OF TRANSMEMBRANE VIRAL GLYCOPROTEINS (1979) (0)
- Neafsey African Malaria Vector Mosquitoes SNP Genotyping Defines Complex Gene-Flow Boundaries Among (2014) (0)
- New Drugs and Drug Resistance in Malaria: Molecular Genetic Analysis. (1995) (0)
- Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention (2023) (0)
- Genetic analysis reveals unique characteristics of Plasmodium falciparum parasite populations in Haiti (2020) (0)
- Triaminopyrimidines antimalarial agent NatComm 2015 (2015) (0)
- Multidrug Resistance in Leishmania donovani (0)
- hmmIBD: software to infer pairwise identity by descent between haploid genotypes (2018) (0)
- Corrigendum to “Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element”: [Mol Biochem Parasitol 2003;129:199–208] (2003) (0)
- High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations (2017) (0)
- Mechanisms of Drug Resistance in Plasmodium Falciparum (1992) (0)
- From Population Genomics to Elucidated Traits in Plasmodium Falciparum: Population Genomics, Genetic Diversity, and Association in Malaria (2013) (0)
- Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal (2017) (0)
- Within-infection diversity of Plasmodium falciparum antigens reflects host-mediated selection (2017) (0)
- Global action for training in malaria elimination (2018) (0)
- Isolation and characterization of an alpha-tubulin gene from Leishmania enriettii. (1983) (0)
- TRANSCRIPTIONAL AND PROTEOMIC CATEGORIZATION OF THE ETIOLOGY OF PNEUMONIA SYNDROME IN PEDIATRIC PATIENTS IN MALARIA ENDEMIC AREAS (2017) (0)
- Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity (2017) (0)
- Temporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia (2019) (0)
- High-throughput profiling of natural acquired humoral immune response to a large panel of known and novel full length ectodomain P. falciparum merozoite vaccine candidates under reduced malaria transmission (2022) (0)
- NOVEL AMINOINDOLE INHIBITORS OF PLASMODIUM FALCIPARUM : IN VIVO EFFICACY AND PRELIMINARY SAFETY ASSESSMENT (2010) (0)
- Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal (2013) (0)
- Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum (2006) (0)
- New Strategies for Drug Discovery and Development for Plasmodium Falciparum (2000) (0)
- RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands (2015) (0)
- ACT PARTNER DRUG EROSION-EVIDENCE OF PPQ RESISTANT PARASITES FROM CAMBODIA (2017) (0)
- Plasmodium falciparum DHODH inhibitor complexes reveal flexible binding site (2014) (0)
- Temporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia (2019) (0)
- Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections (2018) (0)
- trans Splicing inLeishmania enriettii andIdentification of Ribonucleoprotein Complexes Containing theSpliced LeaderandU2 Equivalent RNAs (1988) (0)
- Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing (2019) (0)
- Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways (2022) (0)
- Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal (2012) (0)
- Malaria: Submerged Awareness-Reply (1996) (0)
- Letter from Dyann F. Wirth to Purnell Choppin (1981) (0)
- Kinetoplast DNA minicircies: Regions ofextensive sequence divergence (1987) (0)
- Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance (2022) (0)
- Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering (2022) (0)
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